Best TWAS P=7.41e-23 · Best GWAS P=2.16e-27 conditioned to 0.144
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Putamen basal ganglia | PELI2 | 0.30 | 0.01 | lasso | 4 | 0.01 | 2.4e-01 | 4.9 | 5.2 | 2.1e-07 | 0.02 | 0.11 | 0.08 | TRUE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | KTN1-AS1 | 0.36 | 0.04 | lasso | 11 | 0.05 | 1.4e-02 | 7.5 | 5.5 | 3.0e-08 | -0.14 | 0.09 | 0.42 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | KTN1-AS1 | 0.09 | 0.02 | lasso | 3 | 0.03 | 3.7e-03 | 7.9 | 5.8 | 7.1e-09 | -0.09 | 0.05 | 0.87 | FALSE |
| 4 | GTEx | Esophagus Mucosa | SAMD4A | 0.12 | 0.00 | lasso | 2 | 0.00 | 3.7e-01 | -6.1 | -6.1 | 1.3e-09 | 0.34 | 0.06 | 0.69 | FALSE |
| 5 | GTEx | Lung | KTN1-AS1 | 0.08 | 0.02 | lasso | 4 | 0.01 | 3.5e-02 | 8.0 | 7.5 | 9.1e-14 | -0.12 | 0.04 | 0.81 | TRUE |
| 6 | METSIM | Adipose | ATG14 | 0.05 | 0.06 | lasso | 3 | 0.07 | 4.5e-10 | -6.0 | -5.7 | 1.6e-08 | 0.11 | 1.00 | 0.00 | TRUE |
| 7 | METSIM | Adipose | CNIH1 | 0.06 | 0.00 | blup | 439 | 0.01 | 2.4e-03 | 1.8 | 6.5 | 9.1e-11 | -0.24 | 0.09 | 0.13 | FALSE |
| 8 | METSIM | Adipose | MAPK1IP1L | 0.03 | 0.00 | bslmm | 436 | 0.01 | 4.2e-02 | 4.1 | 5.5 | 3.2e-08 | -0.32 | 0.46 | 0.06 | FALSE |
| 9 | YFS | Blood | SAMD4A | 0.02 | 0.01 | bslmm | 454 | 0.01 | 2.7e-04 | 10.5 | 9.8 | 7.4e-23 | -0.63 | 0.10 | 0.84 | TRUE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GCH1 | 0.05 | 0.02 | blup | 45 | 0.04 | 3.7e-05 | 3.1 | -6.3 | 3.2e-10 | 0.49 | 0.11 | 0.55 | TRUE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FBXO34 | 0.11 | 0.08 | lasso | 4 | 0.08 | 4.4e-09 | 4.7 | 5.2 | 2.1e-07 | -0.09 | 0.81 | 0.18 | FALSE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | C14orf33 | 0.06 | 0.03 | enet | 9 | 0.02 | 2.7e-03 | 7.9 | 5.6 | 2.5e-08 | -0.06 | 0.01 | 0.76 | FALSE |