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chr15:98,493,891-102,400,037

Best TWAS P=1.12e-64 · Best GWAS P=1.06e-94 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADAMTS17	0.15	0.00	blup	728	0.07	2.2e-09	12.86	-7.9	3.2e-15	-0.41	0.09	0.74	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LYSMD4	0.23	0.13	enet	26	0.20	1.9e-23	-5.78	-6.5	8.3e-11	-0.03	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	ADAMTS17	0.14	0.00	enet	19	0.02	5.0e-03	15.80	-15.1	8.6e-52	-0.27	0.23	0.03	TRUE
4	GTEx	Adipose Subcutaneous	LYSMD4	0.15	0.07	lasso	5	0.06	2.2e-05	-5.78	-6.2	4.9e-10	0.00	0.99	0.00	FALSE
5	GTEx	Adipose Subcutaneous	CTD-3076O17.1	0.22	0.05	lasso	6	0.04	2.9e-04	-8.99	-11.6	2.9e-31	0.00	0.80	0.02	TRUE
6	GTEx	Adipose Visceral Omentum	ADAMTS17	0.20	0.00	enet	20	0.05	2.2e-03	-11.65	-15.4	3.0e-53	-0.55	0.11	0.22	TRUE
7	GTEx	Adipose Visceral Omentum	CTD-3076O17.1	0.21	0.00	lasso	6	0.00	6.2e-01	-11.24	-17.0	1.1e-64	-0.12	0.10	0.23	TRUE
8	GTEx	Adrenal Gland	LYSMD4	0.33	0.23	lasso	6	0.21	4.4e-08	-4.79	-6.2	7.8e-10	-0.02	0.81	0.02	TRUE
9	GTEx	Artery Aorta	LYSMD4	0.17	0.13	lasso	3	0.18	4.7e-10	-5.78	-5.7	1.2e-08	0.00	0.99	0.00	FALSE
10	GTEx	Artery Aorta	CTD-3076O17.1	0.34	0.02	lasso	8	0.06	4.8e-04	-8.99	-6.3	3.5e-10	0.10	0.55	0.02	TRUE
11	GTEx	Artery Tibial	ADAMTS17	0.15	0.01	lasso	5	0.00	1.4e-01	-0.33	-5.7	9.7e-09	-0.01	0.14	0.04	FALSE
12	GTEx	Artery Tibial	CTD-3076O17.1	0.18	0.08	lasso	10	0.06	9.2e-06	-8.99	-7.3	2.8e-13	0.09	0.98	0.00	FALSE
13	GTEx	Brain Cerebellum	LYSMD4	0.27	0.28	lasso	4	0.23	1.8e-07	-5.78	-5.9	3.8e-09	0.01	0.70	0.03	FALSE
14	GTEx	Brain Frontal Cortex BA9	LYSMD4	0.32	0.21	lasso	4	0.17	3.7e-05	-5.78	-5.8	5.0e-09	0.01	0.12	0.14	TRUE
15	GTEx	Brain Frontal Cortex BA9	RP11-526I2.5	0.52	0.25	lasso	10	0.32	2.6e-09	-1.99	6.3	2.7e-10	0.15	0.69	0.02	TRUE
16	GTEx	Brain Nucleus accumbens basal ganglia	LYSMD4	0.22	0.22	lasso	4	0.15	7.5e-05	-5.78	-5.3	1.4e-07	0.01	0.23	0.05	FALSE
17	GTEx	Brain Putamen basal ganglia	LYSMD4	0.32	0.03	enet	15	0.11	1.2e-03	-2.36	-8.3	8.9e-17	-0.24	0.08	0.07	TRUE
18	GTEx	Breast Mammary Tissue	CTD-3076O17.1	0.29	-0.01	enet	23	0.07	1.7e-04	-0.20	-5.4	6.0e-08	0.03	0.14	0.04	TRUE
19	GTEx	Breast Mammary Tissue (Female)	LYSMD4	0.22	0.00	lasso	5	0.03	3.5e-02	-5.78	-6.0	2.3e-09	0.01	0.13	0.05	FALSE
20	GTEx	Breast Mammary Tissue (Female)	CTD-3076O17.1	0.29	-0.01	lasso	5	0.00	3.2e-01	-11.32	-10.9	9.0e-28	0.07	0.07	0.05	FALSE
21	GTEx	Breast Mammary Tissue (Female)	CTD-2054N24.2	0.09	0.00	enet	12	0.15	2.8e-05	0.97	-8.8	1.6e-18	-0.38	0.08	0.21	TRUE
22	GTEx	Cells EBV-transformed lymphocytes	RP11-526I2.5	0.41	0.24	lasso	7	0.25	1.0e-08	-3.36	6.1	9.7e-10	0.27	0.63	0.12	FALSE
23	GTEx	Cells Transformed fibroblasts	LRRK1	0.20	0.07	lasso	3	0.10	6.7e-08	-8.44	-8.9	4.4e-19	0.00	0.95	0.00	FALSE
24	GTEx	Colon Sigmoid	LYSMD4	0.20	0.06	lasso	4	0.09	5.2e-04	-5.78	-5.9	4.1e-09	-0.01	0.26	0.09	FALSE
25	GTEx	Colon Sigmoid	CTD-3076O17.1	0.25	0.15	lasso	5	0.09	3.5e-04	-11.35	-10.1	8.0e-24	0.09	0.23	0.04	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	LYSMD4	0.20	0.15	enet	11	0.16	2.9e-06	-5.78	-9.2	3.6e-20	-0.02	0.28	0.04	TRUE
27	GTEx	Esophagus Mucosa	LRRK1	0.21	0.07	lasso	7	0.07	1.5e-05	6.01	-6.5	8.9e-11	-0.02	0.88	0.00	FALSE
28	GTEx	Esophagus Mucosa	CTD-3076O17.1	0.28	0.10	lasso	6	0.11	4.7e-08	-11.20	-9.9	3.6e-23	0.11	1.00	0.00	FALSE
29	GTEx	Esophagus Muscularis	CTD-3076O17.1	0.28	0.11	lasso	6	0.10	6.2e-07	-11.35	-9.5	1.7e-21	0.09	0.96	0.00	TRUE
30	GTEx	Heart Atrial Appendage	ADAMTS17	0.22	0.00	lasso	4	0.09	9.6e-05	-9.01	-14.0	1.6e-44	-0.21	0.12	0.08	TRUE
31	GTEx	Heart Atrial Appendage	LYSMD4	0.19	0.15	enet	32	0.10	1.9e-05	-5.78	-5.9	4.2e-09	0.06	0.61	0.02	FALSE
32	GTEx	Heart Atrial Appendage	CTD-3076O17.1	0.25	0.11	enet	24	0.17	3.8e-08	-9.87	-11.8	3.0e-32	-0.08	0.72	0.02	FALSE
33	GTEx	Heart Atrial Appendage	RP11-526I2.5	0.47	0.39	enet	23	0.37	8.9e-18	-1.99	5.3	1.1e-07	0.18	1.00	0.00	FALSE
34	GTEx	Lung	CTD-3076O17.1	0.15	0.09	enet	13	0.09	2.8e-07	-11.20	-11.9	2.1e-32	0.08	1.00	0.00	TRUE
35	GTEx	Muscle Skeletal	LYSMD4	0.14	0.11	lasso	7	0.14	3.8e-13	-5.78	-5.3	1.3e-07	-0.01	1.00	0.00	TRUE
36	GTEx	Nerve Tibial	LYSMD4	0.41	0.24	enet	49	0.32	2.2e-23	-5.78	-5.3	9.3e-08	0.02	1.00	0.00	FALSE
37	GTEx	Pancreas	LRRK1	0.48	0.08	lasso	10	0.04	1.1e-02	6.02	-7.3	2.5e-13	0.03	0.13	0.18	FALSE
38	GTEx	Pancreas	CTD-3076O17.1	0.24	0.11	enet	6	0.11	2.7e-05	-10.70	-11.4	3.5e-30	0.09	0.53	0.02	FALSE
39	GTEx	Pituitary	LYSMD4	0.30	0.19	enet	6	0.30	2.6e-08	-5.78	-6.5	9.3e-11	0.00	0.47	0.03	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	LYSMD4	0.24	0.20	lasso	5	0.23	7.3e-13	-6.08	-6.3	3.7e-10	-0.02	1.00	0.00	FALSE
41	GTEx	Skin Sun Exposed Lower leg	LRRK1	0.25	0.06	enet	22	0.14	6.7e-12	-4.98	-8.9	3.9e-19	0.01	1.00	0.00	TRUE
42	GTEx	Skin Sun Exposed Lower leg	LYSMD4	0.23	0.11	enet	20	0.18	7.5e-15	-5.78	-6.3	3.0e-10	0.00	1.00	0.00	FALSE
43	GTEx	Skin Sun Exposed Lower leg	CTD-3076O17.1	0.15	0.10	enet	18	0.12	1.5e-10	-11.20	-8.8	1.1e-18	0.12	1.00	0.00	FALSE
44	GTEx	Spleen	LINS	0.56	0.33	lasso	6	0.40	3.4e-11	2.85	-5.5	4.6e-08	-0.21	0.96	0.01	FALSE
45	GTEx	Testis	ADAMTS17	0.30	0.24	lasso	2	0.22	6.7e-10	-11.41	-11.5	1.2e-30	0.09	1.00	0.00	FALSE
46	GTEx	Testis	LYSMD4	0.25	0.13	lasso	5	0.16	8.6e-08	4.39	-5.2	1.6e-07	0.01	0.97	0.00	FALSE
47	GTEx	Testis	TARSL2	0.20	0.00	enet	26	0.10	2.6e-05	2.83	-7.5	4.3e-14	0.00	0.10	0.22	TRUE
48	GTEx	Testis	CTD-3076O17.1	0.45	0.17	enet	19	0.14	1.0e-06	-11.41	-10.6	3.1e-26	0.07	0.90	0.00	FALSE
49	GTEx	Thyroid	RP11-505E24.2	0.15	0.01	lasso	3	0.00	4.3e-01	-1.59	-5.8	7.6e-09	0.00	0.16	0.04	FALSE
50	GTEx	Whole Blood	LYSMD4	0.11	0.01	enet	5	0.03	1.7e-03	-2.00	-5.3	1.5e-07	0.00	0.49	0.03	TRUE
51	METSIM	Adipose	LINS	0.07	0.04	lasso	9	0.02	1.4e-04	2.75	-6.1	1.2e-09	-0.17	0.99	0.00	FALSE
52	METSIM	Adipose	LRRK1	0.06	0.06	lasso	3	0.05	6.7e-08	6.01	-5.9	4.2e-09	-0.04	1.00	0.00	FALSE
53	METSIM	Adipose	LYSMD4	0.23	0.14	enet	57	0.21	2.6e-31	-6.08	-5.7	1.3e-08	-0.08	1.00	0.00	FALSE
54	YFS	Blood	IGF1R	0.14	0.09	enet	25	0.12	6.8e-36	8.05	-8.7	3.9e-18	-0.02	1.00	0.00	TRUE
55	YFS	Blood	LRRK1	0.24	0.16	lasso	5	0.23	4.4e-73	6.01	-9.1	1.1e-19	-0.02	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	LYSMD4	0.07	0.03	blup	57	0.02	3.0e-02	-5.78	-7.3	2.0e-13	0.00	0.01	0.83	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LYSMD4	0.14	0.07	lasso	6	0.10	1.8e-11	-6.08	-5.8	8.1e-09	-0.02	0.00	1.00	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PCSK6	0.09	0.00	blup	236	0.03	1.0e-04	1.38	-6.4	1.2e-10	0.08	0.05	0.04	TRUE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRK1	0.07	0.05	lasso	3	0.04	1.3e-05	-9.39	-10.5	1.3e-25	0.02	0.00	0.99	TRUE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	LYSMD4	0.10	0.07	blup	57	0.11	7.7e-13	-6.08	-5.7	1.5e-08	-0.01	0.00	1.00	TRUE
61	The Cancer Genome Atlas	Lung Adenocarcinoma	IGF1R	0.07	0.05	enet	18	0.03	1.4e-04	-3.66	7.9	3.9e-15	0.06	0.52	0.04	TRUE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	LRRK1	0.08	0.04	lasso	8	0.07	1.7e-07	0.49	-5.3	1.3e-07	-0.04	0.69	0.12	FALSE
63	The Cancer Genome Atlas	Stomach Adenocarcinoma	LYSMD4	0.05	0.02	blup	59	0.01	5.0e-02	-4.79	-6.6	4.0e-11	0.01	0.01	0.81	TRUE
64	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LINS1	0.27	0.04	lasso	6	0.13	2.7e-05	-1.99	-5.7	1.6e-08	-0.15	0.53	0.06	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	ADAMTS17	0.17	0.01	blup	279	0.05	5.2e-06	-0.16	-5.9	2.8e-09	-0.28	0.13	0.04	TRUE