Hub : Genes

PCSK6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0710	0.0290	0.00870	0.009	0.002	0.014	0.007	0.019	2.4e-02	0.1500	6.3e-03	0.04200	0.00210
2	GTEx	Brain Cerebellar Hemisphere	0.3430	0.1060	0.00630	0.043	NA	0.001	NA	0.027	2.9e-02	NA	2.9e-01	NA	0.06700
3	GTEx	Nerve Tibial	0.2131	0.0609	0.00051	0.055	NA	0.052	NA	0.039	9.8e-05	NA	1.3e-04	NA	0.00091
4	METSIM	Adipose	0.0804	0.0278	0.00054	0.007	0.017	0.027	0.018	0.010	2.6e-02	0.0011	5.2e-05	0.00094	0.00950
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0920	0.0348	0.00190	0.003	0.033	0.007	NA	0.006	1.5e-01	0.0001	4.4e-02	NA	0.06300

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.9	1.4	3.1	-1.8	-0.1	0.4	-1.5	-1.2
Bipolar Disorder or Schizophrenia	0.7	1.8	3.6	-1.3	-1.0	1.4	-0.9	-1.9
Depressed Affect (Nagel 2018)	0.7	1.5	4.9	-1.1	0.0	-2.2	-0.5	-1.1
Depression (Nagel 2018)	0.3	0.4	1.3	-0.6	-0.1	-1.1	-0.1	-0.6
Intelligence (Savage-Jansen 2018)	0.3	0.8	3.4	-0.5	-0.1	-1.8	-0.4	0.6
Neuroticism (Nagel 2018)	1.5	3.5	8.3	-1.8	1.0	-2.2	0.0	-2.9
Schizophrenia (2018)	0.7	1.5	3.3	-0.2	-1.3	1.5	0.2	-1.8
Schizophrenia vs Biploar Disorder	0.7	0.9	2.6	0.2	-0.2	0.9	1.6	1.1
Worry (Nagel 2018)	0.4	0.9	2.2	-0.9	0.2	-1.2	0.1	-1.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.7	-0.3	-0.6	-0.1	0.0
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.7	-0.3	0.1	-0.6	0.3
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	-0.4	-0.5	0.3	-0.8	0.4
Crohns Disease (2017)	0.3	0.6	1.2	1.1	-0.3	-0.4	1.0	0.8
Irritable Bowel Disease (IBD)	0.5	1.3	4.0	2.0	0.7	-0.7	0.4	1.1
Ulcerative Colitis (UC)	0.6	1.2	3.2	1.8	1.1	-1.2	-0.3	0.6
Major Depression (MDD)	0.6	0.8	1.8	0.3	1.3	-0.9	0.9	-0.7
Reaction Time	1.0	2.0	9.0	-0.9	-0.1	0.2	-0.2	-3.0
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.1	-0.8	-1.0	-0.6	0.2	0.9
Breast Cancer	0.4	0.8	2.9	0.7	1.7	0.6	0.4	-0.6
Ovarian Cancer	0.2	0.2	0.5	0.4	-0.3	0.6	0.7	0.2
Prostate Cancer	0.7	0.9	3.0	1.0	1.7	-0.3	-0.7	-0.1
Age at First Birth	0.1	0.1	0.3	0.6	-0.1	0.5	-0.1	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.8	-0.9	-1.1	0.0	-1.3	-0.5
Coronary Artery Disease (CAD)	0.3	0.4	1.8	-0.2	0.3	0.1	0.3	-1.4
Crohns Disease (2012)	0.6	0.9	1.6	1.1	-0.9	1.2	-0.1	1.1
Mean Putamen Volume	0.6	0.6	2.5	0.2	-1.6	0.6	0.4	0.5
Fasting Glucose	0.5	0.6	2.0	0.1	-0.2	0.9	-1.4	-0.3
HbA1C	0.3	0.3	1.0	-1.0	-0.3	0.2	-0.7	0.3
HDL Cholesterol	1.2	2.0	5.2	1.2	2.3	1.6	0.1	1.0
LDL Cholesterol	0.6	1.0	3.1	-0.7	0.2	-1.7	1.0	-0.5
Lupus	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	1.2	1.7	5.9	-0.1	1.5	-0.3	-0.7	-2.4
Primary Biliary Cirrhosis	0.6	0.8	3.2	0.5	-0.5	-0.5	-1.8	-0.2
Rheumatoid Arthritis	0.5	0.7	1.8	-0.8	-1.3	-1.0	0.1	-0.2
Schizophrenia (2014)	0.6	1.3	3.0	-0.7	-1.1	1.7	0.4	-1.3
Triglycerides	0.8	1.3	4.7	-0.5	0.7	2.2	0.1	1.0
Type 2 Diabetes (T2D) (2012)	1.1	1.2	3.2	1.0	0.1	0.8	-1.1	1.8
Ulcerative Colitis	0.8	1.2	4.0	2.0	1.1	-0.5	-0.1	0.4
Blood Eosinophil Count	0.1	0.5	1.5	-0.2	-1.2	-0.6	0.7	-0.3
Blood Platelet Count	0.1	1.1	3.8	0.4	-0.1	0.1	2.0	-1.2
Blood Red Count	0.4	3.9	10.9	1.3	-0.2	3.3	2.6	-0.1
Blood White Count	0.6	4.8	20.3	0.8	-0.8	4.5	1.5	0.2
Heel T-Score	0.6	4.7	9.9	2.8	-0.7	3.1	0.9	2.1
BMI	0.1	0.4	0.9	0.8	-0.3	0.4	-0.9	-0.5
Height	0.9	16.7	41.5	-4.3	1.1	-0.7	4.7	-6.4
Waist Hip Ratio (WHR)	0.4	1.9	8.7	0.2	2.9	0.5	-0.6	-0.4
Systolic Blood Pressure	0.6	2.8	7.7	-0.8	-1.2	2.8	0.7	2.0
Smoking Status	0.8	2.0	7.5	0.8	-0.7	0.9	-0.8	2.7
Allergy or Eczema	0.1	0.4	0.7	0.6	-0.7	-0.3	0.8	0.4
Cardiovascular Disease	1.2	4.1	10.8	2.1	-1.7	3.3	-0.2	1.5
Hypothyroidism (self reported)	0.5	1.2	3.4	-0.7	-0.6	0.6	1.9	-1.1
Respiratory disease	0.1	0.2	0.9	-0.2	0.1	-0.2	0.1	-1.0
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.2	0.5	-0.6	0.3	-1.5	1.2
Lung FEV1/FVC ratio	0.5	2.5	6.6	-0.9	-1.7	0.7	-2.6	1.3
Lung FVC	0.2	0.9	1.9	1.2	-0.1	1.0	0.2	1.4
Neuroticism	1.4	3.5	10.1	-1.2	2.0	-1.4	0.0	-3.2
Chronotype (morning person)	1.2	2.9	6.3	1.3	-1.7	-0.6	1.7	2.5
Hair Pigment	0.1	3.3	6.0	1.6	-2.1	1.5	1.1	2.4
Tanning	0.0	0.5	1.0	-0.3	-1.0	-0.9	-0.7	0.3
Hand grip strength (left)	0.6	1.6	2.4	0.6	1.6	-0.7	-1.5	-1.5
Number of treatments/medications taken	0.2	0.4	0.8	0.1	-0.9	-0.7	-0.8	-0.1
Average weekly spirits intake	1.0	1.3	4.6	-2.1	0.1	-0.5	0.2	-1.3
Sensitivity / hurt feelings	1.0	1.7	5.4	-1.4	0.6	0.7	0.5	-2.3
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.7	-1.3	-1.1	0.2	-0.4	-1.2
Hearing difficulty/problems: Yes	0.7	1.1	3.0	-1.1	-0.9	-1.7	-0.4	-0.4
Relative age of first facial hair	0.4	0.9	2.1	-0.2	-1.3	-0.1	0.6	1.5
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	1.8	-0.0	-1.4	-1.3	1.2	1.0
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.9	-0.4	0.2	-0.9	0.6	0.4
Ever had hysterectomy (womb removed)	1.0	1.2	4.5	0.5	0.7	-2.1	-0.7	-0.3
Systolic blood pressure, automated reading	0.4	1.3	6.0	-0.0	-0.1	0.7	0.3	2.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.3	-1.5	-0.6	-0.2	-0.9	-0.7
Angina	1.5	2.0	6.3	-1.6	-2.5	-0.9	0.5	0.2
Medication for hormone replacement therapy	0.8	0.9	2.6	0.6	1.6	-0.6	0.5	0.9
Vitamin and mineral supplements	0.9	1.3	2.2	-0.7	1.2	-1.5	0.3	-1.5
Supplements: Zinc	1.5	1.6	4.7	-0.2	-1.7	-0.7	-2.2	0.3
Medication: Co-codamol	0.4	0.4	1.8	-0.3	-0.1	-1.3	0.4	-0.3
Medication: Metformin	0.5	0.7	1.5	0.4	-1.0	0.4	-1.2	0.9
Diabetes (father)	0.7	0.8	2.1	1.1	-0.7	-0.4	-1.4	0.5
Diabetes (mother)	1.2	1.5	2.6	1.3	1.0	0.2	-1.6	1.6
Severe depression (siblings)	0.4	0.5	1.0	-0.2	-1.0	-0.9	0.2	-0.8
Pack years adult smoking proportion	1.2	1.8	6.8	-0.9	-2.6	-0.9	-0.6	0.2
Impedance of leg (right)	0.3	1.3	3.6	0.6	0.9	1.2	1.9	-0.6
Leg fat-free mass (left)	0.3	1.8	4.9	-1.3	0.3	-1.1	-1.1	-2.2
Trunk fat percentage	0.2	0.7	2.2	1.5	-0.2	-0.7	0.1	-1.0
Hand grip strength (right)	0.3	0.8	3.0	0.0	1.7	0.2	-0.5	-0.8
Townsend deprivation index at recruitment	0.7	0.9	1.5	-0.8	-0.9	1.2	0.6	-1.2
Current tobacco smoking	1.2	1.9	8.5	0.6	-0.6	0.4	0.5	2.9
Average weekly fortified wine intake	0.8	0.9	1.4	-1.2	-0.4	1.2	-0.5	1.2
Maternal smoking around birth	1.1	1.6	6.4	2.5	-0.7	-0.7	0.2	-0.5
Fed-up feelings	0.4	0.7	1.3	-0.8	1.2	-1.0	0.2	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.5	0.8	-0.8	-1.1	-1.2	0.5
Relative age voice broke	1.5	2.2	4.4	-1.0	-1.4	-0.6	2.1	1.9
Taking other prescription medications	0.8	1.2	2.2	-0.4	-0.2	-1.5	1.3	1.3
Age when periods started (menarche)	0.8	1.9	4.7	1.1	-0.3	1.7	-2.2	-0.8
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	4.8	-0.4	1.8	-2.2	-0.3	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	3.0	1.7	1.1	0.6	-0.7	0.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.8	0.8	0.5	1.0	-0.1	1.4
Qualifications: CSEs or equivalent	0.6	0.9	2.2	1.4	-0.3	1.5	0.3	0.0
Serious illness, injury or assault to yourself	0.4	0.5	1.0	-0.2	-0.2	-1.0	-1.0	0.7
High blood pressure	1.1	2.9	5.6	2.3	-0.9	2.4	-0.1	1.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.9	0.3	-0.8	-0.5	1.0	0.9
Multivitamins +/- minerals	1.0	1.3	4.4	0.8	-2.1	0.6	-0.4	0.9
Stomach or abdominal pain in last month	0.3	0.3	0.7	-0.5	-0.0	-0.5	-0.7	-0.8
Supplements: Glucosamine	0.8	1.0	2.5	1.6	0.2	-1.4	-0.7	-0.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	3.9	2.0	0.3	0.4	0.1	-0.5
Medication: Atenolol	0.7	0.8	2.2	-1.5	-1.2	0.5	0.4	0.4
Medication: Levothyroxine sodium	0.5	0.8	1.6	1.2	-0.4	0.8	1.2	0.3
Sitting height	1.3	9.0	18.3	-3.4	2.8	-0.3	2.7	-4.3
Chronic bronchitis/emphysema (father)	1.7	2.0	3.1	0.6	-1.4	-1.8	1.7	-1.4
High blood pressure (mother)	0.5	0.7	2.1	0.6	0.4	0.9	-1.4	-0.2
Body mass index (BMI)	0.2	0.7	1.6	0.7	-0.6	-0.8	-1.3	-0.4
Impedance of leg (left)	0.4	1.8	6.2	0.6	1.1	0.8	2.5	-0.7
Leg predicted mass (left)	0.3	1.8	4.9	-1.3	0.3	-1.1	-1.0	-2.2
Trunk fat mass	0.2	0.9	3.1	0.4	0.1	-1.1	-0.1	-1.8
Waist circumference	0.1	0.4	1.8	0.1	-0.1	-0.1	-0.6	-1.3
Number of incorrect matches in round	0.5	0.8	2.1	-1.2	-1.4	0.6	-0.2	-0.0
Past tobacco smoking	0.3	0.6	1.6	1.3	-0.4	-1.0	0.3	0.2
Alcohol usually taken with meals	0.6	1.0	4.2	-0.4	-0.4	0.1	-0.6	2.1
Nervous feelings	0.7	1.3	4.7	-1.2	0.4	-0.5	0.0	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	-1.0	-0.4	0.6	-0.3	-0.2
Hearing difficulty/problems with background noise	0.5	0.8	1.7	-0.6	-1.2	-1.3	-0.4	-0.5
Hair/balding pattern: Pattern 2	0.5	0.7	1.8	-0.3	0.3	-0.4	1.1	-1.3
Had menopause	0.5	0.6	1.5	-1.2	-0.8	-0.7	0.3	0.6
Had other major operations	0.6	0.7	2.0	0.6	0.9	-0.0	0.7	1.4
Forced vital capacity (FVC)	0.5	2.0	5.2	-0.6	1.2	-1.2	1.2	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.0	1.7	1.5	-0.1	0.2	-0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	-1.0	-0.7	0.7	-0.2	0.9
Qualifications: None of the above	0.2	0.4	0.7	0.1	-0.8	-0.8	0.8	-0.1
Financial difficulties in last 2 years	1.8	2.4	5.0	1.0	2.2	1.9	1.2	-0.9
Mouth/teeth dental problems	1.1	1.7	3.3	0.2	1.1	1.8	1.8	-0.9
Heart attack	0.7	0.9	2.5	-0.3	-1.3	-0.6	1.6	-0.5
Allergy	0.1	0.2	0.5	-0.4	0.6	0.7	-0.5	-0.0
Pain all over the body in last month	1.5	1.6	2.6	1.5	0.3	-1.5	1.6	0.8
Diabetes (self-reported)	0.7	1.1	3.0	-0.1	-1.7	1.0	-1.1	0.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.4	0.9	-1.8	0.2	1.5	-0.3
Medication: Ramipril	0.6	0.7	1.3	-1.0	0.5	0.2	-1.0	-1.2
Medication: Simvastatin	0.2	0.2	0.9	-0.3	-0.9	-0.5	0.0	-0.1
Fluid intelligence score	0.3	0.6	2.0	-0.5	0.1	-0.1	-1.4	1.0
Illnesses of siblings	0.5	0.7	2.2	-0.5	-0.4	-1.5	-0.9	-0.2
Neuroticism score	1.3	2.7	8.5	-1.2	1.6	-0.8	-0.5	-2.9
Weight	0.3	1.7	6.4	-0.8	0.3	-1.1	-0.3	-2.5
Impedance of arm (right)	0.3	1.3	3.4	1.9	0.6	0.5	1.5	0.2
Arm fat percentage (right)	0.3	1.1	3.6	1.9	-0.2	-1.0	-0.6	-0.6
Trunk fat-free mass	0.7	4.3	9.4	-2.6	1.1	-1.9	-0.1	-3.1
Hip circumference	0.2	0.9	3.0	-0.3	-0.8	-0.8	-0.2	-1.7
Time employed in main current job	1.2	1.3	3.1	1.0	-1.2	1.0	-0.3	1.8
Alcohol intake versus 10 years previously	1.2	1.8	4.1	0.1	-0.8	1.8	-1.1	2.0
Father’s age at death	0.9	1.2	3.3	-1.8	-0.1	-0.2	-0.2	-1.5
Worrier / anxious feelings	0.7	1.2	3.8	-0.8	0.5	-0.7	-1.0	-2.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	4.1	-0.5	-2.0	0.0	-0.8	-0.2
Falls in the last year	0.7	0.9	2.5	-0.4	0.4	-1.6	-1.1	-0.8
Hair/balding pattern: Pattern 3	0.3	0.5	1.5	-0.1	-1.2	-0.6	-0.2	0.7
Number of live births	0.4	0.6	1.6	0.4	-0.2	-0.6	-0.9	1.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.9	-0.6	0.2	-0.3	-0.0	-1.7
Pulse rate	0.3	0.6	1.6	0.8	-1.2	0.6	0.3	-0.3
Happiness	1.2	1.4	3.4	0.5	-0.5	1.1	-1.8	1.4
Noisy workplace	0.6	0.8	2.0	1.4	-0.2	-0.8	0.8	0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.5	-1.2	0.1	-0.1	-1.2	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.3	-0.6	0.4	0.2	1.2	-1.5
Mouth/teeth dental problems: Dentures	1.0	1.7	3.1	1.3	0.4	-1.1	-1.5	1.8
Asthma	0.1	0.2	0.5	0.7	0.1	0.2	-0.0	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.5	1.2	-0.5	-0.1	-1.9	0.4
Medication: Cholesterol lowering	0.7	1.2	3.5	0.7	-1.0	0.6	-0.7	1.9
Depression (self-reported)	0.7	0.8	1.7	-1.3	-0.2	-1.0	0.7	-0.9
Medication: Lansoprazole	1.3	1.5	2.7	-0.7	-1.6	0.6	1.2	1.5
Prospective memory result	0.7	0.8	2.3	-0.5	0.5	0.1	-1.2	-1.5
Lung cancer (father)	0.5	0.5	1.5	1.2	-0.6	-0.5	-0.7	0.2
Illnesses of mother	0.5	0.6	1.0	-0.9	-0.8	1.0	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.1	-0.6	0.2	0.1	-0.2	-1.0
Pulse wave Arterial Stiffness index	0.2	0.3	1.2	0.2	-0.3	1.1	0.2	0.4
Impedance of arm (left)	0.3	1.4	3.4	1.5	0.9	0.7	1.9	0.4
Arm fat mass (right)	0.1	0.6	1.2	0.8	-0.4	-1.1	-0.2	-1.0
Trunk predicted mass	0.7	4.2	9.3	-2.6	1.1	-1.9	0.0	-3.0
Standing height	0.9	9.2	21.8	-3.6	2.4	-1.1	2.2	-4.7
Length of working week for main job	0.4	0.4	1.1	-0.1	-0.9	0.5	-1.1	-0.1
Exposure to tobacco smoke at home	0.3	0.3	1.4	-0.1	0.1	0.0	0.6	-1.2
Breastfed as a baby	0.4	0.6	1.0	0.4	0.8	-1.0	-1.0	-0.2
Tense / ‘highly strung’	0.3	0.4	1.1	0.0	0.5	-1.1	0.2	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.8	-1.4	0.2	-0.7	-1.0	-1.1
Hair/balding pattern: Pattern 4	1.1	2.6	6.4	0.9	2.5	-0.3	-2.4	-0.2
Birth weight of first child	0.9	1.6	3.6	-0.9	-0.3	-1.9	-0.6	-1.8
Peak expiratory flow (PEF)	0.4	0.9	2.1	-1.4	0.0	0.1	-0.6	-1.5
Pulse wave reflection index	0.7	0.8	1.8	0.3	0.7	-1.4	0.4	-1.2
Ever highly irritable/argumentative for 2 days	1.5	1.8	6.1	-0.4	0.6	-0.2	2.5	-1.4
Loud music exposure frequency	0.4	0.4	1.1	-0.0	0.3	-0.3	0.9	1.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	4.4	1.0	0.6	2.1	-1.8	-0.4
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	7.0	-1.1	0.5	-2.6	-0.9	-2.2
Blood clot in the leg (DVT)	1.1	1.4	2.5	1.0	-1.6	-1.4	-0.2	-1.3
Medication: Paracetamol	0.8	1.4	3.5	0.9	-0.2	-1.5	-0.7	-1.9
Headache pain in last month	0.5	0.9	1.5	-1.1	1.1	-0.3	-1.2	-0.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.7	-1.1	1.7	-1.2	1.0	-1.1
Glaucoma (self-reported)	1.8	2.2	4.1	-1.6	0.8	-2.0	1.2	-1.5
Gout (self-reported)	0.8	1.1	2.9	0.9	1.3	1.7	-0.6	0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	2.1	0.2	-0.7	0.2	1.4	-0.1
Medication: Amlodipine	1.0	1.3	5.6	0.1	-0.7	2.4	-0.6	0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.7	-0.6	-0.6	0.9	-1.3	0.2
Birth weight	0.8	1.8	2.8	1.7	1.1	-1.6	-1.6	0.3
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.1	-1.8	-0.4	-0.8	0.3	-1.2
High blood pressure (siblings)	1.1	1.5	7.0	-0.6	0.3	2.6	0.4	-0.4
Forced vital capacity (FVC), Best measure	0.3	1.1	3.4	-0.6	1.0	-0.7	0.6	-1.8
Body fat percentage	0.2	0.9	2.0	1.4	-0.2	-0.8	-0.3	-1.2
Leg fat percentage (right)	0.2	0.6	1.2	1.1	-0.7	-0.2	-0.7	-0.9
Arm fat-free mass (right)	0.7	3.6	9.5	-2.4	0.9	-1.2	-0.2	-3.1
Exposure to tobacco smoke outside home	0.2	0.3	1.0	0.3	-1.0	-0.4	-0.3	-0.3
Comparative body size at age 10	0.1	0.2	0.4	-0.6	0.3	0.6	-0.5	0.4
Number of full brothers	0.1	0.2	0.5	0.1	0.7	0.5	-0.2	0.0
Worry too long after embarrassment	1.0	1.7	7.6	0.2	1.0	-0.1	0.3	-2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	4.0	-2.0	0.6	-0.2	0.2	-1.6
Wheeze or whistling in the chest in last year	0.4	0.7	1.5	1.2	-0.8	-0.3	0.0	1.2
Number of children fathered	1.3	1.4	5.5	-0.3	0.3	1.2	2.4	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.0	-0.3	1.4	0.9	-1.4	0.2
Age at first live birth	0.6	1.1	3.2	0.7	-0.1	-0.4	1.8	-1.1
Pulse wave peak to peak time	0.3	0.4	1.0	-0.4	0.6	-1.0	0.0	-0.6
Health satisfaction	0.1	0.1	0.5	-0.2	-0.1	-0.7	0.3	0.1
Shortness of breath walking on level ground	0.7	0.9	2.5	-1.6	-0.8	0.1	-0.1	-1.1
Qualifications: College or University degree	0.1	0.2	0.7	-0.8	0.3	0.1	-0.3	-0.0
Eye problems/disorders: None of the above	0.6	0.7	1.3	1.1	-0.1	0.5	0.9	1.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.5	-0.5	-0.2	-0.8	1.6	1.2
Emphysema/chronic bronchitis	1.3	1.5	2.0	-1.4	-1.3	-1.3	-0.3	-1.3
Medication for pain relief, constipation, heartburn	0.5	0.8	2.5	-0.4	1.6	0.6	0.9	-0.3
Neck or shoulder pain in last month	1.0	1.5	3.2	1.1	1.8	-0.6	-1.1	-1.2
Medication: Blood pressure	0.6	1.1	2.0	0.7	-1.4	1.4	-0.7	0.7
Angina (self-reported)	1.5	1.9	6.6	-1.5	-2.6	-0.7	0.3	0.1
Migraine (self-reported)	0.8	0.9	2.1	-1.5	1.3	-0.5	-0.7	-0.4
Medication: Ibuprofen	1.3	1.5	3.8	1.5	-0.6	-0.9	-1.9	0.7
Medication: Allopurinol	0.3	0.4	1.2	-0.2	0.4	0.8	-1.1	0.2
Medication: Omeprazole	0.4	0.5	1.6	0.3	-0.6	-0.7	-1.3	0.1
Medication: Seretide 50 evohaler	0.2	0.3	0.7	-0.4	-0.7	-0.4	0.8	-0.1
Mean time to correctly identify matches	0.6	1.2	3.8	-1.3	-0.3	-0.2	0.1	-1.9
Heart disease (mother)	0.9	1.1	2.4	0.0	0.7	-1.5	0.1	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.0	-0.5	-0.0	-0.2	-0.7	-1.4
Whole body fat mass	0.2	1.0	3.2	0.7	0.1	-1.1	-0.1	-1.8
Leg fat mass (right)	0.2	0.8	3.0	0.1	-0.2	-0.8	-0.6	-1.7
Arm predicted mass (right)	0.7	3.8	9.2	-2.5	1.0	-1.5	-0.1	-3.0
Pulse rate, automated reading	0.6	2.0	3.9	0.9	-1.4	1.7	-2.0	-0.1
Alcohol intake frequency.	0.6	1.5	4.0	-0.7	-0.7	-1.6	-2.0	-0.1
Comparative height size at age 10	0.9	5.0	12.4	-1.2	2.2	-2.3	1.0	-3.5
Number of full sisters	1.3	1.6	5.2	1.1	0.3	-2.3	1.3	-0.2
Suffer from ‘nerves’	0.8	1.2	3.5	-1.6	-0.3	0.2	0.1	-1.9
Overall health rating	0.2	0.4	0.8	0.2	-0.9	-0.3	0.5	0.8
Chest pain or discomfort	0.5	0.8	2.2	0.3	-1.5	-0.4	-1.2	-0.1
Had major operations	1.7	2.0	5.4	0.7	-1.7	-0.8	2.3	0.9
Age at last live birth	0.5	0.7	2.6	1.6	-1.0	0.0	0.1	0.1
Family relationship satisfaction	0.8	0.9	3.0	-0.3	0.8	-0.4	-1.7	-0.9
Leg pain on walking	0.6	0.8	2.2	1.1	-0.6	0.2	1.5	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.2	1.0	0.3	-0.3	-1.1	-0.2
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.6	0.0	1.4	-1.6	-0.2	-1.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.9	-0.4	-0.6	-0.9	-0.2	0.8
Medication: Aspirin	1.7	2.2	4.8	-0.2	-2.2	0.7	-1.5	1.9
Supplements: Vitamin C	1.2	1.4	3.4	-1.8	-0.3	1.8	-0.4	0.2
Knee pain experienced in last month	1.4	2.2	3.6	1.7	-1.9	0.7	-1.2	1.7
Hypertension (Self-reported)	1.0	2.9	4.8	2.1	-1.0	2.0	-0.6	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.8	0.3	-1.7	-0.1	-0.7	0.8
Illnesses of father: Heart disease	0.3	0.4	1.6	-0.0	-0.1	-0.2	1.3	0.4
Illnesses of siblings: Diabetes	0.4	0.5	1.1	-0.4	1.0	0.5	-1.0	0.0
Smoking status: Previous	0.2	0.3	0.9	-0.5	-0.2	1.0	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	9.3	-0.5	1.2	-0.5	0.9	-3.1
Whole body fat-free mass	0.6	3.2	7.8	-2.2	0.9	-1.5	-0.5	-2.8
Leg fat-free mass (right)	0.3	1.7	4.2	-1.5	0.4	-1.2	-0.8	-2.0
Arm fat percentage (left)	0.2	0.8	2.4	1.6	-0.3	-0.8	-0.4	-0.7
Average weekly red wine intake	0.3	0.5	0.8	-0.8	0.9	-0.2	-0.8	-0.6
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.0	0.2	-0.1	-1.0	-1.0	-0.3
Mood swings	1.7	3.0	6.2	-1.8	0.8	-2.5	-0.7	-2.1
Loneliness, isolation	0.9	1.2	2.0	0.9	0.5	-1.3	-1.2	-1.4
Long-standing illness, disability or infirmity	0.6	1.0	2.0	0.1	-1.3	-1.0	-0.3	1.4
Ever had bowel cancer screening	0.5	0.6	1.9	-0.1	-0.8	-0.4	1.4	0.7
Diabetes diagnosed by doctor	0.6	1.0	2.9	0.2	-1.7	-0.2	-1.3	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.1	1.3	-0.5	-1.1	-0.1	1.4
Friendships satisfaction	0.6	0.7	1.3	-0.8	1.0	0.6	-0.2	-1.2
Qualifications: nursing, teaching	1.4	2.2	5.1	-1.7	2.3	-1.0	-0.1	-1.4
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.4	-0.7	-0.3	-0.5	-0.2
Eye problems/disorders: Cataract	0.2	0.3	0.5	-0.7	0.7	0.2	-0.5	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	4.1	-0.4	-2.0	-0.6	-0.8	-0.3
Medication for cholesterol	0.1	0.1	0.3	-0.1	-0.3	-0.4	0.5	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.2	-1.5	0.5	-1.5	1.2	-0.1
Back pain experienced in last month	0.5	0.8	2.3	0.2	0.8	-0.8	-1.5	0.3
Mineral and other dietary supplements	0.6	0.8	2.3	0.0	0.4	0.9	0.8	-1.5
Breast cancer (self-reported)	0.5	0.6	1.1	-0.2	0.8	0.1	-1.1	-1.1
Asthma (self-reported)	0.1	0.2	0.5	0.5	0.3	0.1	0.0	-0.7
Osteoporosis (self-reported)	1.2	1.5	4.3	1.3	1.1	-2.1	-0.2	-0.1
Osteoarthritis (self-reported)	0.8	1.0	2.0	1.3	-1.0	-0.3	-0.5	1.4
Medication: Aspirin	2.0	2.6	5.2	-0.2	-2.3	0.8	-1.6	2.1
Medication: Gliclazide	0.8	0.9	2.5	0.7	-0.5	1.1	-1.6	0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	2.2	-0.5	-0.1	0.0	-1.5	0.1
Smoking status: Current	1.0	1.6	6.8	0.7	-0.5	0.5	0.5	2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.6	0.0	0.1	2.1	-0.6	0.6
Whole body water mass	0.6	3.2	7.4	-2.3	0.8	-1.6	-0.4	-2.7
Leg predicted mass (right)	0.3	1.7	3.8	-1.5	0.4	-1.2	-0.8	-1.9
Arm fat mass (left)	0.1	0.6	1.6	0.5	-0.3	-0.9	-0.2	-1.3
Number of self-reported non-cancer illnesses	0.8	1.3	3.2	1.7	-0.8	0.2	-0.1	1.8
Average weekly champagne plus white wine intake	0.6	0.9	3.6	-0.9	0.3	-0.0	1.9	-0.0
Miserableness	0.8	1.5	2.5	-1.1	-1.4	-0.7	-1.6	-1.1
Guilty feelings	3.1	4.6	13.9	-1.6	2.2	-1.1	-0.6	-3.7
Wears glasses or contact lenses	0.5	0.6	1.5	-1.0	0.5	0.4	-0.3	1.2
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.0	-0.4	-0.4	-0.4	-0.2
Hearing aid user	1.9	2.2	6.1	2.5	-1.2	1.5	0.1	1.1
Mother’s age at death	0.3	0.4	0.7	0.7	-0.6	0.9	0.6	0.4
Financial situation satisfaction	1.7	2.1	5.6	1.2	2.4	0.8	-1.6	-0.6
Tinnitus: Yes, now most or all of the time	1.8	2.1	4.7	1.7	-1.4	-0.3	1.0	2.2
Commuting to job workplace: Public transport	1.3	1.5	4.1	0.4	-1.2	2.0	0.2	1.4
Eye problems/disorders: Glaucoma	1.2	1.4	3.8	-0.6	0.8	-1.5	0.2	-1.9
Medication: Blood pressure	0.3	0.6	1.0	0.4	-0.4	0.9	-0.9	1.0
Pain type(s) experienced in last month: Hip pain	1.0	1.2	2.6	-0.5	-0.7	-1.1	-1.6	-1.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.8	0.7	0.5	-1.2	0.2	1.4
High cholesterol (Self-reported)	0.8	1.5	2.4	0.9	-1.3	1.3	-0.9	1.6
Medication: Bendroflumethiazide	1.1	1.6	3.2	1.8	1.4	1.1	-0.1	-1.3
Medication: Paracetamol	1.3	2.0	5.2	1.0	0.4	-2.3	-0.9	-1.7
Medication: Lisinopril	2.2	2.8	7.6	1.3	-2.1	2.8	0.3	0.7
Medication: Atorvastatin	2.1	2.6	5.4	1.5	-0.5	2.3	-1.0	2.0
Illnesses of father: High blood pressure	0.9	1.1	2.9	-0.5	0.7	-0.0	1.7	-1.4
Alcohol drinker status: Never	1.5	1.8	6.7	-1.1	-0.4	1.1	-2.6	-0.1
Ever smoked	0.5	0.8	1.2	-1.1	0.7	1.1	-0.7	0.9
Basal metabolic rate	0.5	2.8	7.7	-1.9	0.7	-1.4	-0.4	-2.8
Leg fat percentage (left)	0.2	0.6	1.4	1.2	-0.7	-0.4	-0.3	-0.9
Arm fat-free mass (left)	0.6	2.9	8.3	-1.8	0.9	-1.5	0.0	-2.9
Number of operations (self-reported)	0.9	1.3	5.0	0.4	-0.9	-0.4	0.9	2.2
Average weekly beer plus cider intake	0.4	0.5	1.6	-0.9	0.5	1.3	0.2	0.3
Irritability	0.8	1.4	2.4	-1.6	0.8	-0.1	1.4	-1.4
Risk taking	0.1	0.2	0.7	0.9	0.2	0.4	0.0	0.4
Ever had prostate specific antigen (PSA) test	1.0	1.1	3.3	-1.2	-0.2	-0.7	1.8	0.5
Fractured/broken bones in last 5 years	0.9	1.2	5.7	0.3	-0.3	0.1	0.1	2.4
Age started oral contraceptive pill	1.1	1.4	2.8	-1.3	1.0	1.7	-0.5	-1.1
Diastolic blood pressure, automated reading	0.4	1.2	3.5	0.6	0.0	1.5	1.9	0.4
Ever depressed for a whole week	0.5	0.6	1.3	-1.1	-1.0	0.6	0.5	-0.3
Unable to work because of sickness or disability	0.3	0.4	0.8	0.9	-0.4	0.8	0.5	0.3
Commuting to job workplace: Cycle	1.2	1.4	4.9	-0.4	-1.0	0.8	0.5	2.2
Myopia	0.6	0.8	2.4	0.2	-0.2	1.2	1.5	0.3
Vascular/heart problems diagnosed by doctor	1.0	2.6	5.1	-2.2	1.9	-1.7	-0.0	-1.3
Cholesterol lowering medication	0.1	0.1	0.5	-0.2	-0.7	0.1	0.1	0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.1	0.6	-0.2	-0.7	-1.0	0.7
Pain experienced in last month	0.3	0.5	1.4	-0.9	-0.1	0.6	1.2	0.1
Supplements: Calcium	1.0	1.1	5.2	0.2	-0.2	0.1	-0.0	2.3
Basal cell carcinoma (self-reported)	2.0	2.4	5.9	-1.5	1.1	-1.5	0.3	-2.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.1	-0.2	-1.5	-0.5	1.3	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.2	0.9	-1.5	-1.1	-0.2	-1.1
Heart disease (siblings)	0.8	1.0	2.4	1.0	-1.5	-1.0	0.5	-0.4
Alcohol drinker status: Previous	0.5	0.5	1.9	-1.4	-0.4	-0.2	0.5	0.6
Pack years of smoking	1.6	2.3	8.1	-1.2	-2.8	-1.2	-0.5	0.5
Impedance of whole body	0.3	1.7	5.3	1.4	0.7	0.8	2.3	-0.2
Leg fat mass (left)	0.2	1.0	3.7	0.1	-0.3	-0.9	-0.5	-1.9
Arm predicted mass (left)	0.5	2.6	7.8	-1.7	0.7	-1.3	-0.1	-2.8