Hub : Genes

TRIM25

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.184 0.038 5.7e-09 0.073 0.096 0.075 0.105 0.073 2.9e-09 1.1e-11 2.1e-09 1.1e-12 3.4e-09
2 GTEx Cells EBV-transformed lymphocytes 0.303 0.089 2.1e-03 0.176 NA 0.146 NA 0.154 2.3e-06 NA 1.8e-05 NA 1.0e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.2 0.3 0.4 -0.6 0.5
Bipolar Disorder or Schizophrenia 0.3 0.7 1.3 0.4 -1.1
Depressed Affect (Nagel 2018) 0.1 0.2 0.3 0.6 -0.1
Depression (Nagel 2018) 0.6 0.9 1.1 -1.0 0.9
Intelligence (Savage-Jansen 2018) 0.4 1.3 2.7 -1.6 0.1
Neuroticism (Nagel 2018) 0.4 1.0 1.2 0.9 -1.1
Schizophrenia (2018) 1.3 2.6 3.6 1.3 -1.9
Schizophrenia vs Biploar Disorder 3.3 4.4 8.5 0.5 -2.9
Worry (Nagel 2018) 0.9 2.0 2.5 1.2 -1.6
Alzheimer’s Disease (in mother) 0.5 0.6 1.1 1.0 0.2
Alzheimer’s Disease (in father) 0.1 0.1 0.1 0.4 -0.4
Alzheimer’s Disease (including proxy) 1.0 1.5 2.8 1.7 -0.4
Crohns Disease (2017) 2.6 5.7 10.5 -0.9 -3.2
Irritable Bowel Disease (IBD) 2.4 5.8 10.4 -1.1 -3.2
Ulcerative Colitis (UC) 1.2 2.3 3.2 -1.2 -1.8
Major Depression (MDD) 1.5 1.9 3.2 -0.7 1.8
Reaction Time 0.3 0.6 0.7 0.7 0.9
Verbal and Numeric Reasoning (VNR) 1.2 2.8 4.8 -2.2 0.9
Breast Cancer 0.4 0.9 1.6 0.5 1.3
Ovarian Cancer 0.7 0.9 1.3 0.8 -1.1
Prostate Cancer 0.7 1.0 1.2 0.8 -1.1
Age at First Birth 0.7 1.0 1.9 -1.4 0.3
Bipolar Disorder (2011) 0.5 0.5 0.6 -0.6 0.8
Body Mass Index (BMI) (2010) 1.5 2.0 3.7 -1.9 0.6
Coronary Artery Disease (CAD) 2.4 2.8 5.6 -2.4 -0.1
Crohns Disease (2012) 1.0 1.6 1.8 -1.2 -1.3
Mean Putamen Volume 0.1 0.1 0.2 0.4 0.3
Fasting Glucose 0.7 0.9 0.9 0.9 -0.9
HbA1C 1.5 1.7 2.3 -1.5 1.0
HDL Cholesterol 0.8 1.4 2.7 1.6 0.2
LDL Cholesterol 0.1 0.2 0.3 0.3 -0.6
Lupus 1.7 2.6 5.3 2.3 -0.1
Neuroticism (2016) 1.2 1.7 3.5 1.9 0.1
Primary Biliary Cirrhosis 1.2 1.7 3.0 -1.7 0.6
Rheumatoid Arthritis 0.4 0.5 0.8 0.5 0.9
Schizophrenia (2014) 0.3 0.6 0.6 -0.8 -0.7
Triglycerides 0.0 0.0 0.1 0.3 -0.0
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.1 -1.1 0.1
Ulcerative Colitis 1.8 2.7 2.8 -1.6 -1.7
Blood Eosinophil Count 0.0 0.0 0.1 -0.3 0.1
Blood Platelet Count 1.2 14.4 25.5 5.0 -1.8
Blood Red Count 0.8 7.2 11.2 3.4 -1.8
Blood White Count 1.1 8.3 16.4 4.0 -0.5
Heel T-Score 1.1 9.1 16.0 4.0 -1.5
BMI 0.7 4.3 4.7 -2.2 2.0
Height 2.7 52.6 53.6 -7.2 7.3
Waist Hip Ratio (WHR) 0.5 2.5 4.9 -2.2 -0.1
Systolic Blood Pressure 0.2 1.1 1.5 -1.2 -0.8
Smoking Status 0.9 2.1 4.0 -0.4 2.0
Allergy or Eczema 0.6 1.6 1.7 -1.3 -1.2
Cardiovascular Disease 1.0 3.3 4.9 -2.2 -1.3
Hypothyroidism (self reported) 1.2 2.7 5.1 -0.5 2.2
Respiratory disease 0.0 0.1 0.2 0.5 0.0
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.1 0.3 -0.1
Lung FEV1/FVC ratio 0.1 0.3 0.6 -0.3 -0.7
Lung FVC 1.1 5.5 9.2 3.0 -1.3
Neuroticism 0.5 1.2 1.3 1.1 -1.2
Chronotype (morning person) 1.7 4.0 7.8 2.8 0.4
Hair Pigment 0.1 2.4 3.2 1.8 -1.3
Tanning 0.3 3.1 5.0 2.2 -1.1
Hand grip strength (left) 0.2 0.5 0.8 -0.4 0.9
Number of treatments/medications taken 0.3 0.6 0.9 -0.9 -0.5
Average weekly spirits intake 1.9 2.4 2.8 -1.4 1.7
Sensitivity / hurt feelings 1.2 2.0 3.3 0.9 -1.8
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.2 0.4 0.4
Hearing difficulty/problems: Yes 0.6 0.9 1.0 1.0 0.8
Relative age of first facial hair 2.3 4.7 8.5 2.9 -0.9
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 3.9 2.0 0.5
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.5 -0.7 -0.3
Ever had hysterectomy (womb removed) 2.4 2.7 3.5 -1.9 -1.4
Systolic blood pressure, automated reading 0.5 1.6 3.1 -1.7 0.3
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.7 -0.1 1.3
Angina 0.0 0.0 0.0 0.2 0.1
Medication for hormone replacement therapy 0.1 0.1 0.3 -0.1 -0.5
Vitamin and mineral supplements 0.2 0.3 0.4 -0.5 0.7
Supplements: Zinc 1.4 1.6 3.1 -1.8 -0.1
Medication: Co-codamol 1.2 1.4 2.5 -1.6 -0.5
Medication: Metformin 0.9 1.3 2.6 -1.6 -0.1
Diabetes (father) 0.0 0.0 0.0 -0.1 0.1
Diabetes (mother) 1.1 1.4 2.8 -1.7 -0.4
Severe depression (siblings) 0.8 0.9 1.7 -1.3 -0.2
Pack years adult smoking proportion 0.2 0.3 0.5 0.3 0.7
Impedance of leg (right) 0.4 2.1 4.0 0.3 -2.0
Leg fat-free mass (left) 2.1 11.0 13.8 -2.9 3.7
Trunk fat percentage 1.7 6.9 10.8 -3.3 1.7
Hand grip strength (right) 0.1 0.3 0.3 0.5 -0.5
Townsend deprivation index at recruitment 0.2 0.3 0.6 0.8 -0.2
Current tobacco smoking 1.0 1.7 2.7 0.9 1.6
Average weekly fortified wine intake 0.3 0.3 0.5 0.3 -0.7
Maternal smoking around birth 5.2 7.5 12.7 3.6 1.5
Fed-up feelings 1.0 1.8 3.6 1.9 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 1.7 -1.0 1.3
Relative age voice broke 5.3 8.2 9.5 2.6 -3.1
Taking other prescription medications 0.1 0.2 0.5 -0.0 -0.7
Age when periods started (menarche) 0.9 2.1 3.1 1.1 -1.8
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 1.5 -1.2 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 2.0 0.2 -1.4
Tinnitus: Yes, but not now, but have in the past 0.2 0.3 0.5 -0.7 0.0
Qualifications: CSEs or equivalent 0.0 0.1 0.1 -0.3 -0.2
Serious illness, injury or assault to yourself 0.2 0.2 0.5 -0.7 0.1
High blood pressure 0.7 1.9 1.9 -1.4 -1.4
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.1 -0.6 -1.1
Multivitamins +/- minerals 0.8 1.0 1.3 1.1 -0.8
Stomach or abdominal pain in last month 1.5 1.8 3.5 0.3 -1.9
Supplements: Glucosamine 2.6 3.4 6.3 -2.5 0.7
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.4 0.6 0.6
Medication: Atenolol 0.7 0.8 1.5 -1.2 -0.3
Medication: Levothyroxine sodium 0.2 0.3 0.7 -0.2 0.8
Sitting height 1.6 11.4 19.4 -1.8 4.4
Chronic bronchitis/emphysema (father) 0.6 0.7 1.2 -0.3 -1.1
High blood pressure (mother) 0.8 1.1 1.8 0.7 -1.3
Body mass index (BMI) 0.7 3.0 3.5 -1.9 1.6
Impedance of leg (left) 0.3 1.5 3.0 0.1 -1.7
Leg predicted mass (left) 2.1 11.1 13.7 -2.9 3.7
Trunk fat mass 2.3 10.0 13.3 -3.6 2.6
Waist circumference 2.2 8.2 12.8 -3.6 1.9
Number of incorrect matches in round 0.4 0.6 1.2 -1.1 -0.2
Past tobacco smoking 0.8 1.4 1.7 1.1 -1.3
Alcohol usually taken with meals 0.5 0.9 1.7 -0.2 -1.3
Nervous feelings 0.7 1.3 2.5 1.6 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.2 0.5 0.1 0.7
Hearing difficulty/problems with background noise 0.0 0.0 0.1 0.2 0.1
Hair/balding pattern: Pattern 2 1.3 1.6 3.2 0.2 1.8
Had menopause 2.3 2.9 5.6 -2.4 0.5
Had other major operations 0.7 0.9 1.2 -1.1 -0.7
Forced vital capacity (FVC) 0.0 0.0 0.0 0.1 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.7 2.7 0.8 -1.7
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 3.5 0.1 1.9
Qualifications: None of the above 0.2 0.4 0.8 0.9 -0.0
Financial difficulties in last 2 years 2.5 3.3 6.5 0.3 2.5
Mouth/teeth dental problems 0.2 0.4 0.6 -0.8 -0.3
Heart attack 0.9 1.2 1.3 1.0 -1.2
Allergy 0.4 0.9 1.5 0.5 1.2
Pain all over the body in last month 0.2 0.2 0.3 0.6 0.4
Diabetes (self-reported) 0.2 0.3 0.5 -0.2 0.7
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 2.0 1.4 0.1
Medication: Ramipril 1.8 2.3 4.0 0.7 -2.0
Medication: Simvastatin 0.1 0.2 0.4 -0.6 0.1
Fluid intelligence score 0.2 0.4 0.4 -0.6 0.6
Illnesses of siblings 0.4 0.5 1.0 1.0 0.2
Neuroticism score 1.7 3.5 5.5 2.3 -1.2
Weight 2.4 12.0 13.0 -3.6 3.3
Impedance of arm (right) 0.1 0.4 0.5 -0.7 -0.6
Arm fat percentage (right) 0.8 3.3 5.3 -2.3 1.1
Trunk fat-free mass 1.1 6.6 9.2 -2.0 3.0
Hip circumference 1.7 7.5 10.5 -3.2 2.1
Time employed in main current job 0.3 0.4 0.7 0.3 -0.8
Alcohol intake versus 10 years previously 0.6 0.9 1.9 -0.1 1.4
Father’s age at death 0.3 0.4 0.4 -0.6 -0.6
Worrier / anxious feelings 2.3 4.4 4.7 2.0 -2.2
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.6 0.8 0.4
Falls in the last year 0.8 1.1 1.9 0.6 1.4
Hair/balding pattern: Pattern 3 0.0 0.0 0.0 0.0 -0.0
Number of live births 0.1 0.2 0.3 -0.6 0.2
Forced expiratory volume in 1-second (FEV1) 0.0 0.2 0.3 -0.2 -0.5
Pulse rate 0.6 1.1 2.2 -1.5 0.2
Happiness 0.5 0.6 1.1 1.1 0.3
Noisy workplace 0.2 0.3 0.5 -0.1 0.7
Qualifications: A levels/AS levels or equivalent 0.8 1.8 2.2 -1.1 1.5
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 1.9 -0.8 1.4
Mouth/teeth dental problems: Dentures 0.2 0.4 0.4 -0.5 0.7
Asthma 0.1 0.2 0.3 0.6 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.9 1.4 0.3
Medication: Cholesterol lowering 0.0 0.0 0.0 -0.2 0.1
Depression (self-reported) 0.1 0.1 0.1 0.3 0.1
Medication: Lansoprazole 0.6 0.7 1.3 -1.1 0.0
Prospective memory result 0.2 0.3 0.6 0.8 -0.2
Lung cancer (father) 0.1 0.1 0.2 0.5 -0.0
Illnesses of mother 2.0 2.5 3.8 1.9 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 1.1 -0.7 1.1
Pulse wave Arterial Stiffness index 0.8 0.9 1.5 -0.6 1.2
Impedance of arm (left) 0.3 1.3 1.9 -1.4 -0.8
Arm fat mass (right) 1.5 6.0 7.3 -2.7 2.2
Trunk predicted mass 1.2 6.7 9.1 -2.1 3.0
Standing height 1.7 16.9 17.6 -4.2 4.0
Length of working week for main job 0.0 0.0 0.1 0.2 0.0
Exposure to tobacco smoke at home 0.5 0.6 1.1 0.3 1.1
Breastfed as a baby 0.2 0.3 0.5 -0.4 -0.7
Tense / ‘highly strung’ 0.8 1.3 1.6 1.3 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.3 1.1 0.5
Hair/balding pattern: Pattern 4 0.6 1.6 1.9 -1.4 -1.1
Birth weight of first child 0.9 1.7 2.1 1.1 -1.4
Peak expiratory flow (PEF) 0.3 0.8 1.6 -0.0 -1.3
Pulse wave reflection index 1.3 1.6 3.0 1.7 0.4
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.0 0.0 -1.4
Loud music exposure frequency 0.7 0.8 1.3 1.2 0.4
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 0.0 0.8
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.1 1.0 -0.0
Blood clot in the leg (DVT) 0.0 0.0 0.0 -0.2 0.2
Medication: Paracetamol 0.1 0.1 0.2 0.1 0.5
Headache pain in last month 0.3 0.5 0.7 -0.9 0.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.5 0.4 0.7
Glaucoma (self-reported) 0.8 0.9 1.0 0.9 -1.0
Gout (self-reported) 0.8 1.0 2.0 -1.4 -0.3
Hypothyroidism/myxoedema (self-reported) 1.1 2.1 3.9 -0.6 2.0
Medication: Amlodipine 0.5 0.7 0.7 -0.8 -0.8
Medication: Ventolin 100micrograms inhaler 0.0 0.0 0.0 0.1 -0.1
Birth weight 1.6 3.4 3.8 1.9 -1.8
Chronic bronchitis/emphysema (mother) 2.1 2.4 3.1 -1.8 1.3
High blood pressure (siblings) 0.8 1.1 1.8 -1.4 -0.7
Forced vital capacity (FVC), Best measure 0.3 1.0 1.4 -0.8 1.2
Body fat percentage 1.2 4.6 7.9 -2.8 1.1
Leg fat percentage (right) 0.5 1.9 3.8 -1.9 0.2
Arm fat-free mass (right) 1.8 9.2 11.3 -2.7 3.4
Exposure to tobacco smoke outside home 2.9 3.9 5.7 -2.4 1.5
Comparative body size at age 10 0.2 0.6 0.9 0.6 -1.0
Number of full brothers 0.3 0.4 0.6 0.5 0.8
Worry too long after embarrassment 1.3 2.2 4.0 2.0 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 3.6 -0.3 1.9
Wheeze or whistling in the chest in last year 0.0 0.1 0.1 -0.3 0.3
Number of children fathered 2.4 2.8 4.8 0.8 2.2
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.3 -0.4 -0.6
Age at first live birth 1.6 2.9 3.0 -1.7 1.7
Pulse wave peak to peak time 0.4 0.5 0.9 0.3 -0.9
Health satisfaction 5.1 6.7 7.1 -2.7 2.5
Shortness of breath walking on level ground 1.9 2.2 3.5 -1.0 1.9
Qualifications: College or University degree 0.5 1.6 3.1 -1.8 0.3
Eye problems/disorders: None of the above 0.3 0.4 0.5 0.7 0.5
Mouth/teeth dental problems: Loose teeth 1.0 1.1 2.2 0.2 1.5
Emphysema/chronic bronchitis 3.2 3.6 4.1 -1.8 2.0
Medication for pain relief, constipation, heartburn 0.1 0.1 0.3 -0.5 -0.1
Neck or shoulder pain in last month 1.3 1.9 2.2 -1.2 1.5
Medication: Blood pressure 0.5 0.9 1.4 0.5 -1.2
Angina (self-reported) 0.1 0.1 0.2 0.5 -0.1
Migraine (self-reported) 0.0 0.0 0.1 -0.3 -0.1
Medication: Ibuprofen 1.0 1.3 2.5 1.6 0.2
Medication: Allopurinol 0.3 0.3 0.5 -0.4 0.7
Medication: Omeprazole 1.6 1.9 2.1 1.3 -1.5
Medication: Seretide 50 evohaler 1.5 1.7 3.2 0.5 1.8
Mean time to correctly identify matches 0.2 0.5 0.5 0.6 0.7
Heart disease (mother) 0.9 1.1 1.4 -1.2 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.1 -0.3 0.1
Whole body fat mass 1.8 7.6 10.1 -3.2 2.3
Leg fat mass (right) 1.4 5.5 7.9 -2.8 1.8
Arm predicted mass (right) 1.6 8.1 9.1 -2.7 3.0
Pulse rate, automated reading 0.1 0.4 0.5 -0.5 -0.7
Alcohol intake frequency. 0.6 1.4 2.7 0.3 1.6
Comparative height size at age 10 4.5 24.8 25.6 -4.9 5.1
Number of full sisters 0.3 0.4 0.4 -0.5 0.6
Suffer from ‘nerves’ 0.8 1.2 2.4 1.6 -0.2
Overall health rating 0.0 0.1 0.2 -0.4 0.1
Chest pain or discomfort 0.5 0.7 1.5 1.2 -0.0
Had major operations 3.5 4.1 8.1 2.8 0.3
Age at last live birth 2.7 3.9 4.6 -2.1 1.8
Family relationship satisfaction 1.7 2.1 2.7 -1.6 1.3
Leg pain on walking 1.5 1.9 3.4 -0.6 1.9
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 2.3 0.8 -1.5
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 0.1 -0.5
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.0 0.1 -1.4
Medication: Aspirin 0.3 0.4 0.8 -0.2 0.9
Supplements: Vitamin C 2.2 2.6 4.7 -0.7 2.2
Knee pain experienced in last month 0.4 0.6 1.1 -1.1 -0.2
Hypertension (Self-reported) 0.6 1.8 2.0 -1.3 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.5 3.0 3.8 1.5 -1.9
Illnesses of father: Heart disease 0.7 1.0 2.0 0.1 -1.4
Illnesses of siblings: Diabetes 1.0 1.3 2.5 -0.2 -1.6
Smoking status: Previous 0.6 0.9 1.7 -1.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 5.0 -1.0 2.2
Whole body fat-free mass 1.6 9.0 11.9 -2.5 3.5
Leg fat-free mass (right) 2.1 11.2 15.1 -2.7 3.9
Arm fat percentage (left) 1.1 4.4 7.0 -2.6 1.4
Average weekly red wine intake 0.6 0.9 1.8 -1.3 -0.3
Handedness (chirality/laterality): Left-handed 0.8 1.0 1.8 0.4 -1.4
Mood swings 1.0 1.8 3.0 1.7 0.8
Loneliness, isolation 0.0 0.0 0.1 0.2 -0.2
Long-standing illness, disability or infirmity 1.1 1.7 2.7 -0.9 1.6
Ever had bowel cancer screening 0.5 0.5 0.6 -0.8 0.6
Diabetes diagnosed by doctor 0.1 0.2 0.4 -0.6 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.8 1.9 3.8 -0.3 1.9
Friendships satisfaction 1.0 1.3 2.2 -0.5 1.5
Qualifications: nursing, teaching 0.4 0.6 0.7 -0.7 0.8
Commuting to job workplace: Walk 1.0 1.1 1.3 0.9 -1.1
Eye problems/disorders: Cataract 0.0 0.0 0.1 0.1 0.3
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.6 -0.8 0.1
Medication for cholesterol 0.8 1.2 1.5 0.9 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 0.9 0.9 -0.5
Back pain experienced in last month 0.3 0.4 0.4 0.7 0.6
Mineral and other dietary supplements 0.3 0.4 0.5 0.7 -0.4
Breast cancer (self-reported) 0.9 1.0 1.2 1.1 -0.9
Asthma (self-reported) 0.2 0.5 0.9 0.9 -0.2
Osteoporosis (self-reported) 2.8 3.4 6.5 0.6 -2.5
Osteoarthritis (self-reported) 1.2 1.6 1.6 -1.3 1.2
Medication: Aspirin 0.2 0.3 0.6 0.0 0.7
Medication: Gliclazide 2.4 2.7 2.9 -1.7 1.6
Illnesses of father: None of the above (group 1) 2.0 2.4 3.1 -1.8 1.3
Smoking status: Current 0.9 1.4 2.5 0.6 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.5 2.5 1.6 -1.6
Whole body water mass 1.7 9.6 12.7 -2.5 3.6
Leg predicted mass (right) 2.1 11.3 15.2 -2.7 3.9
Arm fat mass (left) 1.9 7.9 9.6 -3.1 2.5
Number of self-reported non-cancer illnesses 0.2 0.3 0.4 0.6 0.6
Average weekly champagne plus white wine intake 2.1 2.9 4.4 1.2 -2.1
Miserableness 1.3 2.3 4.4 -0.3 2.1
Guilty feelings 1.0 1.6 2.2 1.5 -0.9
Wears glasses or contact lenses 0.6 0.7 0.9 -0.7 1.0
Ever taken oral contraceptive pill 4.8 5.4 9.8 -1.0 3.1
Hearing aid user 3.5 3.9 4.9 2.2 1.7
Mother’s age at death 0.0 0.0 0.0 -0.1 0.2
Financial situation satisfaction 0.6 0.7 1.4 1.2 0.1
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.5 0.7 0.3
Commuting to job workplace: Public transport 0.8 1.0 1.9 -0.0 1.4
Eye problems/disorders: Glaucoma 0.1 0.1 0.1 0.4 -0.0
Medication: Blood pressure 1.1 2.0 3.0 -1.7 -1.0
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.6 -1.3 -0.0
Supplements: Fish oil (including cod liver oil) 2.1 2.8 3.5 -1.9 1.4
High cholesterol (Self-reported) 0.1 0.2 0.3 0.6 -0.4
Medication: Bendroflumethiazide 0.2 0.3 0.6 0.3 -0.8
Medication: Paracetamol 0.1 0.2 0.4 -0.0 0.6
Medication: Lisinopril 0.4 0.6 0.8 -0.6 0.9
Medication: Atorvastatin 0.6 0.7 0.7 -0.8 0.9
Illnesses of father: High blood pressure 0.0 0.0 0.0 -0.0 0.1
Alcohol drinker status: Never 0.1 0.1 0.3 0.5 -0.1
Ever smoked 0.4 0.7 1.0 -0.7 1.0
Basal metabolic rate 1.8 9.9 12.5 -2.7 3.5
Leg fat percentage (left) 0.7 2.4 4.5 -2.1 0.5
Arm fat-free mass (left) 1.5 7.4 9.3 -2.4 3.0
Number of operations (self-reported) 0.6 0.9 1.9 0.2 -1.4
Average weekly beer plus cider intake 0.2 0.3 0.5 -0.7 0.1
Irritability 0.0 0.1 0.1 -0.3 0.1
Risk taking 0.1 0.2 0.2 0.5 0.3
Ever had prostate specific antigen (PSA) test 2.1 2.4 4.6 -2.1 -0.4
Fractured/broken bones in last 5 years 0.7 0.9 1.7 1.3 -0.4
Age started oral contraceptive pill 0.4 0.5 0.6 -0.6 -0.8
Diastolic blood pressure, automated reading 0.6 1.9 3.8 -2.0 -0.2
Ever depressed for a whole week 0.5 0.7 1.2 0.3 1.1
Unable to work because of sickness or disability 1.2 1.6 3.2 1.8 0.0
Commuting to job workplace: Cycle 0.6 0.8 1.1 0.7 1.0
Myopia 0.4 0.6 0.9 -0.9 0.6
Vascular/heart problems diagnosed by doctor 0.5 1.2 1.8 0.8 1.4
Cholesterol lowering medication 0.7 1.0 1.8 -0.4 -1.4
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 0.7 0.7 -0.8
Pain experienced in last month 0.0 0.1 0.1 -0.4 -0.1
Supplements: Calcium 0.0 0.0 0.1 0.3 0.1
Basal cell carcinoma (self-reported) 1.9 2.2 4.0 -2.0 0.7
Heart attack/myocardial infarction (self-reported) 1.0 1.2 1.7 0.9 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.3 -0.5 0.1
Heart disease (siblings) 0.2 0.3 0.4 -0.4 0.6
Alcohol drinker status: Previous 1.2 1.4 2.3 -0.7 1.5
Pack years of smoking 0.2 0.3 0.4 0.4 0.6
Impedance of whole body 0.3 1.3 1.6 -1.0 -1.3
Leg fat mass (left) 1.6 6.1 8.1 -2.8 2.0
Arm predicted mass (left) 1.6 8.0 10.0 -2.4 3.2