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chr17:55,704,465-58,613,330

Best TWAS P=1.16e-14 · Best GWAS P=1.53e-15 conditioned to 0.511

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RAD51C	0.23	0.37	bslmm	317	0.39	4.6e-50	6.3	-5.8	4.9e-09	-0.56	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	RAD51C	0.23	0.34	enet	21	0.34	1.3e-28	6.2	6.5	9.1e-11	0.63	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	RAD51C	0.14	0.13	lasso	1	0.10	5.2e-06	6.2	6.2	5.5e-10	0.60	0.97	0.01	FALSE
4	GTEx	Brain Cerebellar Hemisphere	RAD51C	0.28	0.29	enet	32	0.29	3.3e-08	6.6	-6.5	8.7e-11	-0.63	0.80	0.16	FALSE
5	GTEx	Brain Cerebellum	RAD51C	0.34	0.28	lasso	8	0.24	9.4e-08	6.2	-6.0	1.9e-09	-0.61	0.93	0.05	FALSE
6	GTEx	Brain Cortex	RAD51C	0.28	0.27	enet	20	0.30	5.4e-09	5.8	-6.2	4.2e-10	-0.61	0.92	0.06	FALSE
7	GTEx	Brain Frontal Cortex BA9	RAD51C	0.40	0.44	lasso	7	0.41	6.0e-12	6.1	-6.6	5.3e-11	-0.68	0.78	0.22	FALSE
8	GTEx	Brain Hippocampus	RAD51C	0.16	0.14	enet	6	0.14	4.2e-04	6.6	-6.6	4.5e-11	-0.60	0.13	0.30	FALSE
9	GTEx	Brain Hypothalamus	RAD51C	0.23	0.22	lasso	7	0.21	1.2e-05	5.8	-5.8	6.1e-09	-0.59	0.54	0.10	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	RAD51C	0.38	0.19	lasso	11	0.12	3.8e-04	5.3	-5.7	1.1e-08	-0.62	0.14	0.55	FALSE
11	GTEx	Brain Putamen basal ganglia	SUPT4H1	0.30	0.30	lasso	7	0.26	6.5e-07	5.1	-6.2	7.5e-10	-0.72	0.17	0.59	FALSE
12	GTEx	Breast Mammary Tissue	RAD51C	0.16	0.22	lasso	8	0.21	6.7e-11	6.2	6.2	5.3e-10	0.60	0.99	0.01	FALSE
13	GTEx	Breast Mammary Tissue (Male)	RAD51C	0.18	0.09	lasso	9	0.05	2.3e-02	6.1	7.7	1.2e-14	0.89	0.03	0.80	TRUE
14	GTEx	Breast Mammary Tissue (Female)	RAD51C	0.15	0.16	lasso	10	0.10	5.2e-04	6.2	6.2	5.5e-10	0.60	0.32	0.26	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	RAD51C	0.21	0.10	lasso	6	0.17	2.8e-06	5.3	6.3	3.7e-10	0.67	0.65	0.26	FALSE
16	GTEx	Cells Transformed fibroblasts	RAD51C	0.20	0.20	lasso	7	0.18	7.4e-14	6.2	6.2	4.3e-10	0.61	0.99	0.01	FALSE
17	GTEx	Colon Transverse	RAD51C	0.12	0.08	enet	14	0.10	1.2e-05	6.2	7.1	1.6e-12	0.69	0.37	0.62	FALSE
18	GTEx	Esophagus Mucosa	VMP1	0.07	0.00	enet	30	0.02	1.8e-02	4.2	5.2	2.3e-07	0.09	0.08	0.06	TRUE
19	GTEx	Esophagus Mucosa	RAD51C	0.26	0.32	lasso	8	0.35	3.0e-24	6.2	6.6	3.2e-11	0.64	1.00	0.00	FALSE
20	GTEx	Esophagus Mucosa	SKA2	0.10	0.02	enet	23	0.08	3.4e-06	6.2	5.8	5.6e-09	0.63	0.08	0.92	FALSE
21	GTEx	Esophagus Muscularis	RAD51C	0.10	0.05	enet	16	0.06	1.2e-04	6.3	5.5	4.2e-08	0.52	0.60	0.22	FALSE
22	GTEx	Lung	RAD51C	0.14	0.10	lasso	12	0.10	9.8e-08	6.2	6.2	6.3e-10	0.60	1.00	0.00	FALSE
23	GTEx	Nerve Tibial	RAD51C	0.10	0.08	enet	19	0.08	1.3e-06	6.1	6.3	2.9e-10	0.65	0.98	0.01	FALSE
24	GTEx	Pancreas	RAD51C	0.11	0.05	lasso	9	0.05	2.4e-03	6.1	6.5	9.3e-11	0.54	0.32	0.40	FALSE
25	GTEx	Pituitary	RAD51C	0.24	0.19	enet	22	0.20	7.3e-06	6.1	-6.1	1.1e-09	-0.61	0.32	0.10	FALSE
26	GTEx	Pituitary	BZRAP1-AS1	0.16	0.04	enet	8	0.02	8.0e-02	-3.9	-5.6	1.9e-08	-0.61	0.08	0.13	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	RAD51C	0.19	0.19	enet	20	0.21	5.6e-12	6.2	6.5	1.1e-10	0.64	1.00	0.00	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	SKA2	0.08	0.00	enet	6	0.00	3.5e-01	6.3	6.0	1.8e-09	0.58	0.06	0.47	FALSE
29	GTEx	Skin Sun Exposed Lower leg	RAD51C	0.17	0.15	enet	14	0.16	8.4e-13	6.2	6.0	1.7e-09	0.60	1.00	0.00	FALSE
30	GTEx	Spleen	RAD51C	0.22	0.02	enet	23	0.03	6.4e-02	6.1	6.0	2.3e-09	0.65	0.08	0.52	FALSE
31	GTEx	Stomach	RAD51C	0.08	0.07	lasso	4	0.03	1.5e-02	5.3	5.5	4.8e-08	0.57	0.09	0.76	FALSE
32	GTEx	Testis	TRIM37	0.17	0.23	lasso	6	0.19	6.3e-09	-4.4	-5.8	4.9e-09	-0.61	0.68	0.31	FALSE
33	GTEx	Thyroid	RAD51C	0.12	0.11	lasso	5	0.08	6.8e-07	6.2	6.8	8.7e-12	0.71	0.97	0.03	FALSE
34	GTEx	Vagina	RAD51C	0.23	0.13	lasso	5	0.08	6.2e-03	5.2	5.2	2.4e-07	0.50	0.32	0.08	FALSE
35	GTEx	Whole Blood	RAD51C	0.29	0.18	enet	21	0.18	1.2e-16	6.2	6.5	5.9e-11	0.65	1.00	0.00	FALSE
36	METSIM	Adipose	RAD51C	0.08	0.09	bslmm	314	0.09	9.7e-14	6.1	6.6	4.4e-11	0.68	0.99	0.01	FALSE
37	NTR	Blood	RAD51C	0.08	0.13	bslmm	312	0.14	1.9e-41	6.6	6.6	5.4e-11	0.63	0.98	0.02	FALSE
38	YFS	Blood	MTMR4	0.02	0.01	bslmm	334	0.01	1.3e-05	1.2	-5.3	1.1e-07	-0.60	0.55	0.34	FALSE
39	YFS	Blood	PRR11	0.04	0.03	lasso	7	0.03	1.1e-10	4.5	5.3	1.1e-07	0.37	1.00	0.00	FALSE
40	YFS	Blood	RAD51C	0.23	0.45	lasso	16	0.45	4.6e-167	6.3	6.4	1.4e-10	0.63	1.00	0.00	FALSE
41	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RAD51C	0.18	0.12	lasso	2	0.11	7.6e-10	6.2	6.2	4.3e-10	0.61	0.26	0.74	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	RAD51C	0.07	0.07	lasso	3	0.07	1.6e-14	6.3	6.3	2.8e-10	0.61	0.24	0.76	FALSE
43	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RAD51C	0.24	0.23	lasso	3	0.22	2.2e-11	6.2	6.4	1.5e-10	0.64	0.09	0.91	FALSE
44	The Cancer Genome Atlas	Colon Adenocarcinoma	RAD51C	0.27	0.20	lasso	7	0.20	1.1e-11	6.2	6.1	1.0e-09	0.60	0.28	0.72	FALSE
45	The Cancer Genome Atlas	Esophageal Carcinoma	RAD51C	0.19	0.08	lasso	3	0.08	2.1e-03	6.2	5.8	4.8e-09	0.57	0.02	0.44	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAD51C	0.24	0.24	lasso	4	0.23	7.6e-26	6.3	6.4	1.2e-10	0.63	0.28	0.72	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SKA2	0.03	0.00	blup	42	0.00	2.5e-01	5.6	5.8	7.3e-09	0.51	0.04	0.46	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DYNLL2	0.03	0.01	blup	34	0.02	5.6e-03	-5.8	5.3	1.1e-07	0.18	0.00	0.82	TRUE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	PRR11	0.03	0.03	enet	5	0.03	8.5e-05	5.6	5.5	4.0e-08	0.54	0.06	0.68	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	RAD51C	0.07	0.06	lasso	3	0.06	5.1e-08	6.3	6.7	2.3e-11	0.67	0.06	0.93	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RAD51C	0.17	0.18	lasso	2	0.18	1.1e-19	6.3	6.3	3.9e-10	0.61	0.28	0.72	FALSE
52	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RAD51C	0.25	0.14	lasso	4	0.12	7.5e-06	6.2	5.8	6.6e-09	0.59	0.06	0.80	FALSE
53	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PPM1E	0.12	0.02	blup	88	0.07	7.0e-04	-4.8	-5.7	9.6e-09	-0.58	0.05	0.32	FALSE
54	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RAD51C	0.10	0.09	lasso	1	0.08	4.5e-04	6.2	-6.2	6.4e-10	-0.61	0.04	0.59	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	C17orf71	0.02	0.01	blup	23	0.01	4.6e-02	-3.6	6.1	1.4e-09	0.56	0.02	0.57	FALSE
56	The Cancer Genome Atlas	Soft Tissue Sarcoma	MTMR4	0.07	0.00	blup	40	0.03	6.6e-03	8.0	-7.6	3.4e-14	-0.89	0.00	0.80	FALSE
57	The Cancer Genome Atlas	Stomach Adenocarcinoma	RAD51C	0.23	0.20	lasso	5	0.20	1.4e-14	6.2	6.2	5.2e-10	0.61	0.26	0.74	FALSE
58	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SEPT4	0.14	0.00	blup	40	0.05	7.1e-03	1.2	6.6	5.4e-11	0.77	0.01	0.54	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	C17orf71	0.03	0.01	blup	23	0.01	2.3e-02	5.7	6.2	7.9e-10	0.55	0.02	0.62	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	RAD51C	0.10	0.08	lasso	5	0.10	7.7e-10	5.8	6.6	5.4e-11	0.69	0.14	0.86	FALSE