TWAS hub - MTMR4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0168	0.0071	0.00015	0.006	0.014	0.011	0.014	0.010	0.0047	1.4e-05	0.00015	1.3e-05	0.00017
2	TCGA	Soft Tissue Sarcoma	0.0650	0.0430	0.00610	0.005	0.030	-0.002	NA	0.008	0.1500	6.7e-03	0.45000	NA	0.09700

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Intelligence (Savage-Jansen 2018)	11.7	35.9	52.6	-4.4	-7.3
Verbal and Numeric Reasoning (VNR)	11.7	28.0	38.4	-4.2	-6.2
Fluid intelligence score	10.6	22.0	32.8	-3.4	-5.7
Supplements: Glucosamine	8.7	11.3	13.7	-3.7	-3.0
Relative age of first facial hair	6.7	13.9	15.9	-3.4	-4.0
Qualifications: CSEs or equivalent	6.6	8.7	10.8	2.6	3.3
Age at first live birth	6.6	11.7	16.6	-2.6	-4.1
Age at last live birth	6.2	9.0	12.9	-2.3	-3.6
Mineral and other dietary supplements	6.2	8.3	9.0	2.8	3.0
Medication: Aspirin	5.8	7.7	10.6	-2.2	-3.3
Age at First Birth	5.5	7.9	8.3	-2.8	-2.9
Prostate Cancer	5.3	7.5	11.0	3.3	2.0
Pulse rate	4.8	8.0	9.4	3.1	2.6
Ever had bowel cancer screening	4.8	5.6	7.1	-2.0	-2.7
Age started oral contraceptive pill	4.8	6.0	6.7	-2.3	-2.6
Supplements: Calcium	4.8	5.3	6.8	-2.6	-2.0
Qualifications: A levels/AS levels or equivalent	4.5	10.0	17.4	-1.6	-4.2
Birth weight of first child	4.5	8.1	10.8	-3.3	-2.3
Supplements: Vitamin C	4.5	5.3	5.7	-2.4	-2.2
Financial situation satisfaction	4.4	5.5	6.1	2.2	2.5
Diabetes (father)	4.1	5.1	8.0	1.5	2.8
Qualifications: College or University degree	4.1	12.8	16.1	-3.1	-4.0
Medication: Aspirin	4.1	5.3	8.0	-1.6	-2.8
Chronotype (morning person)	3.9	8.9	12.1	2.4	3.5
Prospective memory result	3.9	4.8	5.2	2.1	2.3
Commuting to job workplace: Car/motor vehicle	3.7	4.2	7.2	2.7	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.7	4.3	4.9	-2.2	-1.9
Qualifications: NVQ or HND or HNC or equivalent	3.6	4.4	6.1	1.6	2.5
Breast Cancer	3.5	8.5	11.7	-2.3	-3.4
Supplements: Fish oil (including cod liver oil)	3.5	4.6	5.1	-2.3	-2.0
Diverticular disease/diverticulitis (self-reported)	3.3	3.9	4.9	2.2	1.7
Vitamin and mineral supplements	3.2	4.4	4.4	2.1	2.1
Loneliness, isolation	3.2	4.4	8.4	-2.9	-0.6
Unable to work because of sickness or disability	3.2	4.2	5.3	-2.3	-1.8
Average weekly red wine intake	3.1	4.6	7.4	-1.4	-2.7
Qualifications: nursing, teaching	3.1	4.8	6.7	-1.7	-2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	3.0	4.5	5.9	-2.4	-1.8
Chest pain or discomfort	3.0	4.4	6.5	-1.5	-2.5
Commuting to job workplace: Public transport	3.0	3.6	4.1	-2.0	-1.8
Crohns Disease (2012)	2.8	4.6	5.6	-2.4	-1.9
Serious illness, injury or assault to yourself	2.7	3.3	4.9	-2.2	-1.3
Rheumatoid Arthritis	2.6	3.6	7.2	2.7	0.1
Age when periods started (menarche)	2.6	6.2	10.5	-1.4	-3.2
Osteoarthritis (self-reported)	2.6	3.4	3.8	-1.9	-1.7
Ever depressed for a whole week	2.6	3.2	4.8	-1.2	-2.2
Exposure to tobacco smoke at home	2.5	2.8	5.0	2.2	0.8
Supplements: Zinc	2.4	2.6	2.8	-1.6	-1.7
Had other major operations	2.4	3.0	4.9	-1.0	-2.2
Standing height	2.4	23.3	31.7	-3.9	-5.6
Height	2.2	42.8	57.5	-5.3	-7.6
Triglycerides	2.1	3.4	3.9	-1.7	-2.0
Average weekly spirits intake	2.1	2.6	3.0	-1.7	-1.5
Hearing difficulty/problems: Yes	2.1	3.2	4.8	2.2	1.3
Sitting height	2.1	14.8	22.1	-2.7	-4.7
Bipolar Disorder (2011)	2.0	2.0	2.4	1.2	1.6
Medication: Atenolol	2.0	2.5	4.4	-0.7	-2.1
Hair/balding pattern: Pattern 4	2.0	4.9	7.3	-1.6	-2.7
Neck or shoulder pain in last month	2.0	2.8	4.2	1.2	2.0
Medication: Seretide 50 evohaler	2.0	2.3	2.9	-1.3	-1.7
Friendships satisfaction	2.0	2.5	4.3	0.9	2.1
Wheeze or whistling in the chest in last year	1.9	3.3	5.9	2.4	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	2.8	1.3	1.7
Headache pain in last month	1.8	3.0	4.3	1.3	2.1
Systolic blood pressure, automated reading	1.7	4.9	5.1	2.2	2.3
Relative age voice broke	1.7	2.6	3.6	-1.2	-1.9
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	4.5	-1.0	-2.1
Number of full brothers	1.7	2.1	2.5	1.6	1.3
Irritability	1.7	2.8	3.1	-1.6	-1.8
Respiratory disease	1.6	3.5	4.7	-1.6	-2.2
Number of incorrect matches in round	1.6	2.6	3.1	-1.5	-1.8
Nervous feelings	1.6	3.0	4.6	-2.1	-1.2
Pain all over the body in last month	1.6	1.7	2.2	1.5	1.2
HbA1C	1.5	1.7	2.5	-1.6	-0.9
Multivitamins +/- minerals	1.5	1.9	2.0	-1.4	-1.4
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	1.8	-1.3	-1.3
Neuroticism score	1.5	3.2	5.0	-2.2	-1.2
Number of live births	1.5	2.1	4.1	2.0	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	3.5	-1.9	-0.3
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	1.9	-1.3	-1.4
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	3.3	1.8	1.1
Exposure to tobacco smoke outside home	1.4	1.9	2.6	1.1	1.6
Alcohol drinker status: Never	1.4	1.7	3.1	-1.8	-0.5
Alcohol drinker status: Previous	1.4	1.5	1.8	-1.3	-1.2
Reaction Time	1.3	2.4	4.8	-0.2	2.2
Blood Eosinophil Count	1.3	9.9	13.3	-3.6	-2.5
Ever used hormone-replacement therapy (HRT)	1.3	1.6	2.0	1.1	1.4
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.4	1.6	0.7
Falls in the last year	1.3	1.8	2.7	-1.0	-1.6
Impedance of arm (left)	1.3	5.9	6.0	-2.4	-2.5
Suffer from ‘nerves’	1.3	2.0	3.8	-1.9	-0.5
Had major operations	1.3	1.5	1.7	1.1	1.3
Hypothyroidism (self reported)	1.2	2.7	3.9	2.0	1.2
Ever had hysterectomy (womb removed)	1.2	1.4	1.4	1.1	1.2
High blood pressure (mother)	1.2	1.7	2.8	0.8	1.7
Worrier / anxious feelings	1.2	2.2	3.3	-1.8	-1.1
Hair/balding pattern: Pattern 3	1.2	1.8	2.9	-1.7	-0.8
Noisy workplace	1.2	1.5	2.4	0.8	1.6
Worry too long after embarrassment	1.2	2.1	3.3	-0.9	-1.8
Pulse wave peak to peak time	1.2	1.4	1.5	-1.1	-1.2
Mean time to correctly identify matches	1.2	2.3	4.6	0.0	2.1
Financial difficulties in last 2 years	1.1	1.4	2.0	-1.4	-0.9
Impedance of arm (right)	1.1	4.9	5.8	-2.0	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	1.8	-1.3	-1.0
Guilty feelings	1.1	1.6	1.7	-1.3	-1.3
Commuting to job workplace: Cycle	1.1	1.3	2.5	-0.1	-1.6
Schizophrenia vs Biploar Disorder	1.0	1.3	2.3	-1.5	0.5
HDL Cholesterol	1.0	1.7	3.5	1.9	0.1
Schizophrenia (2014)	1.0	2.2	4.3	-2.1	0.4
Type 2 Diabetes (T2D) (2012)	1.0	1.1	1.9	-0.6	-1.4
Systolic Blood Pressure	1.0	5.2	7.9	2.8	1.6
Lung FEV1/FVC ratio	1.0	4.9	7.6	-2.8	-1.5
Townsend deprivation index at recruitment	1.0	1.4	2.2	-1.5	-0.8
Taking other prescription medications	1.0	1.5	2.4	-1.6	-0.8
Mouth/teeth dental problems	1.0	1.5	2.9	1.7	-0.2
Loud music exposure frequency	1.0	1.1	2.1	0.3	1.4
Medication: Amlodipine	1.0	1.5	2.9	0.1	-1.7
Fractured/broken bones in last 5 years	1.0	1.2	1.3	-1.1	-1.1
Myopia	1.0	1.4	2.4	0.7	-1.5
Major Depression (MDD)	0.9	1.1	1.4	0.9	1.2
Frequency of depressed mood in last 2 weeks	0.9	1.3	1.6	-1.0	-1.3
Angina	0.9	1.2	1.3	-1.0	-1.1
Length of working week for main job	0.9	1.0	1.1	-0.9	-1.0
Tense / ‘highly strung’	0.9	1.5	2.8	-0.5	1.7
Medication: Ventolin 100micrograms inhaler	0.9	1.2	1.4	-1.2	-1.0
Pulse rate, automated reading	0.9	2.9	4.8	2.2	1.1
Medication for cholesterol	0.9	1.3	2.5	0.4	1.6
Primary Biliary Cirrhosis	0.8	1.2	1.9	0.6	1.4
Medication for hormone replacement therapy	0.8	0.9	1.3	1.1	0.7
Qualifications: None of the above	0.8	1.6	2.3	1.0	1.5
Asthma	0.8	1.6	2.3	-0.9	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	1.5	-1.2	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.0	1.4	0.3
Crohns Disease (2017)	0.7	1.6	2.3	-1.5	-0.9
Neuroticism (2016)	0.7	1.0	2.0	-1.4	0.0
Number of treatments/medications taken	0.7	1.2	1.9	-0.7	-1.4
Fed-up feelings	0.7	1.3	2.5	0.3	1.6
Hair/balding pattern: Pattern 2	0.7	0.9	1.0	0.9	1.0
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.6	-0.3	1.3
Forced vital capacity (FVC), Best measure	0.7	2.4	4.5	-0.5	-2.1
Leg fat-free mass (right)	0.7	3.6	4.9	-1.5	-2.2
Eye problems/disorders: Cataract	0.7	0.8	1.3	-0.6	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	1.9	-0.6	1.4
Asthma (self-reported)	0.7	1.5	2.2	-0.9	-1.5
Illnesses of father: None of the above (group 1)	0.7	0.8	0.9	-0.8	-1.0
Leg predicted mass (right)	0.7	3.7	4.9	-1.6	-2.2
Mother’s age at death	0.7	0.9	1.3	-0.7	-1.2
Eye problems/disorders: Glaucoma	0.7	0.8	1.5	0.3	1.2
Diastolic blood pressure, automated reading	0.7	2.2	3.6	1.9	0.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.4	-1.2	-0.6
Pack years of smoking	0.7	1.0	1.0	-1.0	-1.0
Alzheimer’s Disease (including proxy)	0.6	0.9	1.3	1.1	0.7
Irritable Bowel Disease (IBD)	0.6	1.5	2.6	-1.6	-0.6
Blood Platelet Count	0.6	7.5	15.0	-3.9	-0.2
Blood White Count	0.6	4.8	8.0	1.3	2.8
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.1	1.4	0.5
Sensitivity / hurt feelings	0.6	1.0	1.7	-1.3	-0.5
Leg fat-free mass (left)	0.6	2.9	4.2	-1.3	-2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.1	-0.8	-1.8
Leg fat percentage (right)	0.6	2.2	2.9	1.7	1.2
Number of full sisters	0.6	0.7	0.8	0.8	-0.9
Family relationship satisfaction	0.6	0.7	1.4	-1.2	-0.3
Smoking status: Previous	0.6	0.9	1.2	1.1	0.8
Long-standing illness, disability or infirmity	0.6	0.9	1.3	-1.1	-0.7
Risk taking	0.6	0.8	1.3	1.1	0.6
Vascular/heart problems diagnosed by doctor	0.6	1.5	2.9	-1.7	-0.5
Schizophrenia (2018)	0.5	1.0	1.9	-1.4	0.3
Mean Putamen Volume	0.5	0.6	1.0	0.4	-1.0
Neuroticism	0.5	1.3	2.2	-1.5	-0.6
Severe depression (siblings)	0.5	0.6	0.9	-0.5	-1.0
Pack years adult smoking proportion	0.5	0.7	0.9	-0.9	-0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.5	-0.7	-0.7
Leg predicted mass (left)	0.5	2.7	4.0	-1.2	-2.0
Forced vital capacity (FVC)	0.5	1.8	3.5	-0.4	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	1.2	1.1	1.1
Heart attack	0.5	0.6	1.1	-1.0	-0.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	2.9	-0.7	-1.7
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.9	1.0	0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.3	-0.4	-1.1
Gout (self-reported)	0.5	0.7	0.9	0.7	1.0
High blood pressure (siblings)	0.5	0.7	0.8	-0.9	0.8
Medication for pain relief, constipation, heartburn	0.5	0.8	1.0	0.9	1.0
Migraine (self-reported)	0.5	0.7	0.8	0.9	0.8
Medication: Ibuprofen	0.5	0.5	0.9	1.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.1	-0.0	-1.5
Whole body fat-free mass	0.5	2.8	4.1	-1.3	-2.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.7	0.7	0.8
Whole body water mass	0.5	2.6	3.8	-1.1	-2.0
Average weekly champagne plus white wine intake	0.5	0.7	0.9	0.9	-0.7
Hearing aid user	0.5	0.6	0.8	0.7	0.9
Medication: Blood pressure	0.5	1.0	1.2	0.8	-1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.0	-1.0	-0.6
Basal metabolic rate	0.5	2.5	3.8	-1.1	-1.9
Leg fat percentage (left)	0.5	2.0	2.7	1.6	1.1
Depression (Nagel 2018)	0.4	0.5	0.6	-0.8	-0.7
Worry (Nagel 2018)	0.4	0.8	1.6	-1.3	0.1
Blood Red Count	0.4	3.6	5.8	2.4	1.2
BMI	0.4	2.4	4.3	2.1	0.7
Allergy or Eczema	0.4	1.0	1.4	-1.2	-0.8
Cardiovascular Disease	0.4	1.2	2.3	1.5	0.3
Hand grip strength (right)	0.4	1.0	1.6	0.7	-1.3
Body mass index (BMI)	0.4	1.7	1.7	1.3	1.3
Medication: Simvastatin	0.4	0.5	0.8	0.6	-0.9
Trunk fat-free mass	0.4	2.4	3.3	-1.2	-1.8
Pulse wave Arterial Stiffness index	0.4	0.4	0.5	0.6	0.7
Trunk predicted mass	0.4	2.3	3.1	-1.2	-1.8
Glaucoma (self-reported)	0.4	0.5	1.0	0.1	1.0
Angina (self-reported)	0.4	0.6	0.6	-0.8	-0.7
Illnesses of siblings: Diabetes	0.4	0.5	0.9	-1.0	0.2
Diabetes diagnosed by doctor	0.4	0.7	1.4	1.2	0.2
Medication: Gliclazide	0.4	0.5	0.5	0.7	-0.6
Smoking status: Current	0.4	0.7	0.9	-0.9	-0.6
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.6	0.8	0.6
Number of operations (self-reported)	0.4	0.6	0.9	1.0	0.6
Average weekly beer plus cider intake	0.4	0.5	0.6	-0.7	-0.7
Cholesterol lowering medication	0.4	0.6	1.2	0.1	-1.1
Impedance of whole body	0.4	1.9	2.3	-1.2	-1.5
Bipolar Disorder or Schizophrenia	0.3	0.8	1.7	-1.3	0.1
Neuroticism (Nagel 2018)	0.3	0.8	1.2	-1.1	-0.6
LDL Cholesterol	0.3	0.5	0.9	-0.4	-0.9
Ulcerative Colitis	0.3	0.5	1.0	-1.0	0.0
Waist Hip Ratio (WHR)	0.3	1.1	1.5	-1.2	-0.9
Hand grip strength (left)	0.3	0.9	1.8	-0.1	-1.3
Current tobacco smoking	0.3	0.4	0.7	-0.9	-0.4
Medication: Ramipril	0.3	0.4	0.6	-0.8	-0.4
Hip circumference	0.3	1.3	2.5	-0.4	-1.6
Medication: Lansoprazole	0.3	0.4	0.5	0.7	0.5
Peak expiratory flow (PEF)	0.3	0.6	1.2	-0.1	-1.1
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.9	0.2
Arm fat-free mass (right)	0.3	1.5	2.3	-0.8	-1.5
Number of children fathered	0.3	0.3	0.3	-0.5	-0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.6	-0.8	-0.3
Arm predicted mass (right)	0.3	1.3	2.2	-0.6	-1.5
Alcohol intake frequency.	0.3	0.7	1.2	-0.4	1.1
Knee pain experienced in last month	0.3	0.5	0.9	0.0	-1.0
Hypertension (Self-reported)	0.3	0.9	1.7	1.3	0.1
Illnesses of father: Heart disease	0.3	0.4	0.7	0.3	0.8
Miserableness	0.3	0.5	1.0	-0.3	-1.0
Medication: Lisinopril	0.3	0.4	0.7	0.2	-0.8
Medication: Atorvastatin	0.3	0.3	0.5	0.7	-0.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.4	-0.6	0.5
Pain experienced in last month	0.3	0.5	0.6	0.8	-0.7
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	-0.0	0.8
Ulcerative Colitis (UC)	0.2	0.3	0.5	-0.7	-0.3
Ovarian Cancer	0.2	0.3	0.3	-0.6	-0.6
Lupus	0.2	0.3	0.4	0.6	0.5
Lung FVC	0.2	1.2	1.9	1.4	0.7
Hair Pigment	0.2	5.7	10.2	1.0	3.2
Medication: Metformin	0.2	0.2	0.2	0.5	-0.5
Diabetes (mother)	0.2	0.3	0.4	-0.4	-0.7
High blood pressure	0.2	0.5	1.0	1.0	-0.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	0.3	0.6
Waist circumference	0.2	0.7	1.4	-0.3	-1.2
Weight	0.2	1.2	2.1	-0.5	-1.4
Father’s age at death	0.2	0.3	0.5	-0.2	-0.7
Mouth/teeth dental problems: Dentures	0.2	0.4	0.6	-0.8	0.5
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.4	-0.7
Birth weight	0.2	0.3	0.5	-0.7	0.4
Comparative body size at age 10	0.2	0.6	1.1	0.3	1.0
Medication: Blood pressure	0.2	0.4	0.7	-0.4	-0.8
Medication: Omeprazole	0.2	0.2	0.5	-0.1	0.7
Heart disease (mother)	0.2	0.3	0.6	-0.0	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.7	0.2
Breast cancer (self-reported)	0.2	0.2	0.4	0.6	-0.3
Ever smoked	0.2	0.3	0.3	0.6	-0.5
Arm predicted mass (left)	0.2	1.0	1.9	-0.4	-1.4
Bipolar Disorder (2018)	0.1	0.1	0.1	-0.4	-0.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	0.0	0.6
Coronary Artery Disease (CAD)	0.1	0.2	0.3	-0.6	0.0
Fasting Glucose	0.1	0.1	0.1	-0.1	-0.3
Heel T-Score	0.1	0.8	1.6	1.3	0.1
Tanning	0.1	0.6	1.2	0.3	1.1
Trunk fat percentage	0.1	0.2	0.5	0.1	-0.7
Maternal smoking around birth	0.1	0.1	0.2	-0.3	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	-0.6	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	-0.1	0.6
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.2	-0.4	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.4	0.1
Medication: Levothyroxine sodium	0.1	0.2	0.2	0.5	-0.3
Impedance of leg (left)	0.1	0.2	0.5	-0.1	-0.7
Trunk fat mass	0.1	0.5	1.0	-0.2	-1.0
Past tobacco smoking	0.1	0.2	0.5	-0.7	0.1
Hearing difficulty/problems with background noise	0.1	0.1	0.3	-0.1	-0.5
Had menopause	0.1	0.1	0.1	0.3	-0.3
Diabetes (self-reported)	0.1	0.1	0.1	0.2	-0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.2	0.4
Illnesses of siblings	0.1	0.2	0.4	0.6	-0.2
Arm fat percentage (right)	0.1	0.3	0.5	0.7	0.5
Time employed in main current job	0.1	0.1	0.2	-0.1	0.4
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.4	-0.1
Happiness	0.1	0.1	0.2	0.0	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.1	-0.5
Depression (self-reported)	0.1	0.1	0.2	-0.5	-0.1
Lung cancer (father)	0.1	0.1	0.1	-0.2	0.3
Breastfed as a baby	0.1	0.1	0.1	-0.4	-0.2
Pulse wave reflection index	0.1	0.2	0.3	0.1	0.6
Medication: Paracetamol	0.1	0.1	0.2	0.0	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.7	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.5	-0.2
Health satisfaction	0.1	0.1	0.2	0.5	0.1
Shortness of breath walking on level ground	0.1	0.2	0.2	0.3	0.4
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.2	-0.5
Medication: Allopurinol	0.1	0.1	0.1	-0.3	0.3
Whole body fat mass	0.1	0.2	0.4	0.1	-0.6
Leg fat mass (right)	0.1	0.3	0.6	0.7	0.1
Overall health rating	0.1	0.3	0.6	0.8	0.1
Leg pain on walking	0.1	0.2	0.2	-0.3	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.4	0.3
Commuting to job workplace: Walk	0.1	0.1	0.1	-0.4	-0.0
Back pain experienced in last month	0.1	0.1	0.2	-0.1	0.5
Osteoporosis (self-reported)	0.1	0.1	0.1	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	0.5	-0.2
Wears glasses or contact lenses	0.1	0.2	0.3	-0.5	-0.3
High cholesterol (Self-reported)	0.1	0.3	0.5	0.7	-0.2
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.4	0.1
Medication: Paracetamol	0.1	0.2	0.4	-0.1	-0.6
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.0	0.5
Arm fat-free mass (left)	0.1	0.5	0.9	-0.2	-1.0
Leg fat mass (left)	0.1	0.4	0.7	0.8	0.1
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	-0.1	-0.1
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.0	-0.3
Body Mass Index (BMI) (2010)	0.0	0.1	0.1	0.2	0.3
Smoking Status	0.0	0.1	0.2	-0.2	-0.4
Medication: Co-codamol	0.0	0.0	0.1	0.2	0.3
Impedance of leg (right)	0.0	0.1	0.2	0.3	-0.4
Average weekly fortified wine intake	0.0	0.0	0.1	0.2	-0.1
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.0	-0.0	0.2
Alcohol usually taken with meals	0.0	0.1	0.1	0.4	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	0.3	0.2
Allergy	0.0	0.0	0.0	0.0	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.1	0.1	0.3	0.1
Illnesses of mother	0.0	0.0	0.0	-0.0	-0.1
Arm fat mass (right)	0.0	0.1	0.2	0.5	0.2
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.0	-0.1	0.1
Body fat percentage	0.0	0.2	0.3	0.6	-0.2
Eye problems/disorders: None of the above	0.0	0.0	0.1	-0.1	0.2
Comparative height size at age 10	0.0	0.0	0.0	0.0	0.1
Arm fat percentage (left)	0.0	0.1	0.1	0.3	0.3
Mood swings	0.0	0.0	0.0	0.1	0.2
Arm fat mass (left)	0.0	0.0	0.0	-0.0	0.0
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.2	-0.2
Ever taken oral contraceptive pill	0.0	0.0	0.0	-0.2	-0.1
Heart disease (siblings)	0.0	0.0	0.1	-0.3	0.0

Hub : Genes

MTMR4

Models

Trait associations