TWAS hub - TMEM185B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1130	0.0410	1.9e-06	0.100	NA	0.109	NA	0.111	1.4e-08	NA	3.3e-09	NA	2.3e-09
2	GTEx	Adrenal Gland	0.2653	0.0954	3.7e-03	-0.003	NA	0.009	NA	0.016	4.1e-01	NA	1.5e-01	NA	8.7e-02
3	GTEx	Artery Tibial	0.0713	0.0313	3.3e-04	0.063	NA	0.033	NA	0.041	1.1e-05	NA	1.1e-03	NA	3.4e-04
4	GTEx	Brain Nucleus accumbens basal ganglia	0.3350	0.1420	4.7e-03	0.049	NA	-0.001	NA	0.065	2.0e-02	NA	3.5e-01	NA	8.1e-03
5	GTEx	Breast Mammary Tissue	0.0510	0.0250	3.9e-03	0.031	NA	0.033	NA	0.035	1.0e-02	NA	7.9e-03	NA	6.4e-03
6	GTEx	Breast Mammary Tissue (Female)	0.0514	0.0483	1.3e-01	-0.007	NA	-0.005	NA	-0.010	5.7e-01	NA	5.1e-01	NA	9.0e-01
7	GTEx	Cells Transformed fibroblasts	0.1260	0.0470	1.0e-04	0.095	NA	0.066	NA	0.078	1.3e-07	NA	1.1e-05	NA	1.7e-06
8	GTEx	Lung	0.0686	0.0362	6.4e-03	0.004	NA	0.001	NA	-0.003	1.6e-01	NA	2.8e-01	NA	5.8e-01
9	GTEx	Muscle Skeletal	0.0934	0.0377	1.4e-03	0.007	NA	0.028	NA	0.018	6.7e-02	NA	8.1e-04	NA	5.8e-03
10	GTEx	Testis	0.1240	0.0490	7.8e-05	0.091	NA	0.120	NA	0.116	7.9e-05	NA	5.7e-06	NA	8.0e-06
11	YFS	Blood	0.1296	0.0257	0.0e+00	0.019	0.085	0.083	0.085	0.074	5.9e-07	1.8e-26	6.8e-26	1.7e-26	4.2e-23
12	TCGA	Kidney Renal Clear Cell Carcinoma	0.0256	0.0165	3.1e-03	0.028	0.014	0.014	NA	0.016	3.4e-04	8.8e-03	8.4e-03	NA	5.2e-03
13	TCGA	Pancreatic Adenocarcinoma	0.0730	0.0470	5.3e-03	0.029	0.035	0.021	NA	0.035	2.2e-02	1.3e-02	4.6e-02	NA	1.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Blood Platelet Count	12.3	142.6	246.5	12.3	11.2	12.6	12.6	15.7	14.5	9.3	13.4	7.8	12.0	-2.8	11.3	14.0
Friendships satisfaction	7.9	9.8	13.7	-3.7	-2.7	-3.3	-2.9	-3.0	-3.2	-3.5	-3.7	-2.5	-3.4	-1.9	-3.2	-3.3
Falls in the last year	4.4	5.9	12.2	-2.6	-2.6	-3.0	-3.5	-3.0	-3.2	-0.8	-2.2	-0.8	-2.4	0.5	-2.2	-2.5
Illnesses of father: High blood pressure	4.3	5.4	7.8	-2.8	-2.2	-2.4	-2.5	-2.4	-2.4	-2.5	-2.7	-2.4	-2.5	-0.9	-1.9	-2.0
Medication: Aspirin	4.2	5.6	10.8	2.4	2.0	2.3	2.8	1.9	1.9	2.0	2.0	3.3	2.4	0.8	2.9	2.9
Osteoporosis (self-reported)	4.2	5.2	7.6	2.2	2.4	2.1	2.2	2.5	2.1	2.4	2.8	2.3	2.4	0.4	2.4	2.5
Lung FEV1/FVC ratio	3.8	19.4	29.3	4.8	4.8	5.2	3.6	4.3	4.4	3.9	4.6	2.6	5.4	0.9	5.3	5.2
Medication: Aspirin	3.6	4.7	7.6	2.3	1.8	2.2	2.7	2.0	1.8	1.8	2.0	2.8	2.1	0.6	2.6	2.7
Chest pain or discomfort	3.2	4.7	7.9	-2.6	-2.1	-2.5	-2.8	-2.0	-1.4	-2.5	-2.5	-0.0	-2.5	-0.4	-2.2	-2.5
Breast Cancer	3.0	7.3	15.1	-2.5	-2.2	-2.9	-2.4	-3.9	-3.1	-2.1	-3.1	-0.3	-2.6	3.2	-2.1	-3.0
Heel bone mineral density (BMD) T-score, automated (left)	3.0	6.8	9.8	-2.9	-2.6	-3.0	-2.3	-2.3	-2.1	-2.8	-3.1	-2.7	-2.9	-0.5	-3.0	-2.6
Wheeze or whistling in the chest in last year	3.0	5.3	8.6	-2.9	-2.9	-2.8	-2.6	-2.5	-2.5	-1.8	-2.8	-0.6	-2.3	0.2	-1.7	-2.2
Ever taken oral contraceptive pill	3.0	3.4	8.2	-1.9	-1.6	-1.9	-1.2	-0.6	-1.7	-1.8	-1.7	-2.9	-2.1	-1.2	-2.2	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.7	3.1	4.9	-1.9	-2.2	-1.9	-2.2	-1.7	-1.7	-1.8	-1.6	-0.5	-2.0	-0.8	-2.1	-1.8
Frequency of tenseness / restlessness in last 2 weeks	2.6	4.0	10.0	-2.2	-2.2	-2.4	-2.9	-3.2	-2.6	-0.9	-2.0	0.2	-1.4	0.9	-0.9	-1.5
Commuting to job workplace: Cycle	2.6	3.1	6.4	-1.8	-1.3	-1.9	-1.8	-1.8	-1.5	-1.4	-1.4	-1.4	-2.1	-0.2	-2.5	-2.5
Medication: Lansoprazole	2.5	2.8	4.6	-1.8	-1.7	-1.8	-2.1	-1.7	-1.3	-1.6	-1.8	0.7	-1.9	-0.6	-1.9	-2.0
Guilty feelings	2.5	3.8	8.1	-1.9	-2.5	-2.5	-2.9	-2.2	-2.3	-0.8	-1.3	-1.1	-1.9	-0.2	-1.9	-2.0
Average weekly spirits intake	2.4	2.9	5.4	1.7	1.7	1.8	2.3	1.5	1.4	1.9	1.6	2.3	1.7	1.3	1.4	1.6
Medication: Amlodipine	2.4	3.4	6.1	-2.0	-1.7	-2.1	-2.5	-1.7	-2.3	-1.2	-1.8	-0.7	-2.2	1.6	-1.5	-1.9
Health satisfaction	2.2	2.8	7.1	-1.9	-1.3	-1.7	-1.5	-1.1	-1.8	-1.6	-1.4	-2.7	-2.0	-0.7	-1.7	-1.5
Pain type(s) experienced in last month: Hip pain	2.2	2.8	7.3	-1.6	-2.0	-2.0	-2.7	-2.0	-1.3	-0.5	-1.0	-0.2	-1.8	0.4	-1.8	-2.0
Ever smoked	2.2	3.8	6.0	-1.9	-1.5	-1.9	-1.8	-1.8	-1.9	-1.4	-2.3	-2.4	-2.2	-1.0	-2.3	-2.4
Medication: Ventolin 100micrograms inhaler	2.1	2.7	4.7	-1.7	-1.7	-1.2	-2.2	-1.4	-1.3	-1.8	-2.1	-1.7	-1.6	-1.7	-1.3	-1.4
Medication: Omeprazole	2.1	2.4	5.9	-1.7	-0.7	-1.3	-1.4	-1.8	-2.4	-1.7	-2.3	-1.6	-1.2	0.3	-1.1	-1.5
Back pain experienced in last month	2.0	3.0	4.8	-1.6	-1.7	-2.1	-2.0	-1.8	-1.2	-1.2	-1.4	-2.0	-1.9	-0.4	-1.9	-2.2
Basal cell carcinoma (self-reported)	2.0	2.4	4.2	-1.7	-1.4	-1.9	-1.1	-2.0	-1.9	-1.3	-1.8	-0.9	-1.7	0.8	-1.4	-1.5
Stomach or abdominal pain in last month	1.9	2.4	6.8	-1.6	-2.6	-1.6	-2.0	-1.7	-1.6	-1.0	-1.7	0.4	-1.4	-0.6	-1.5	-1.4
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	6.8	-2.2	-2.0	-2.2	-2.6	-2.1	-1.0	-1.3	-2.1	-0.3	-1.9	0.1	-1.0	-1.8
Comparative body size at age 10	1.9	5.1	8.2	-2.6	-2.9	-2.6	-2.4	-1.9	-1.2	-2.1	-2.1	-1.6	-2.8	-1.5	-2.6	-2.5
Type 2 Diabetes (T2D) (2012)	1.8	2.1	4.3	1.7	1.8	2.1	1.7	1.8	1.8	0.9	1.4	0.3	1.5	-0.2	0.5	1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.2	8.1	-2.2	-1.8	-2.0	-1.3	-1.3	-1.4	-2.8	-2.6	-2.0	-2.4	-1.4	-2.4	-2.1
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	5.6	-1.6	-0.7	-1.3	-0.7	-0.3	-0.1	-1.9	-1.0	-2.4	-1.6	-2.2	-1.7	-1.5
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	6.8	-1.6	-0.8	-1.7	-0.7	-2.2	-2.6	-1.7	-2.0	-0.3	-1.5	1.2	-2.0	-2.3
Vitamin and mineral supplements	1.7	2.3	5.0	-1.4	-2.1	-2.0	-2.0	-1.8	-2.2	-0.5	-1.3	-1.2	-1.4	0.2	-0.3	-1.3
Exposure to tobacco smoke outside home	1.7	2.3	4.8	-1.7	-1.2	-1.6	-0.9	-0.8	-0.8	-2.2	-1.7	-1.5	-2.0	-1.3	-1.7	-1.7
Shortness of breath walking on level ground	1.7	2.1	4.0	-1.8	-1.5	-1.7	-1.9	-2.0	-1.0	-1.5	-1.6	-0.9	-1.5	-0.0	-0.9	-1.2
Mean time to correctly identify matches	1.7	3.3	6.1	1.9	2.2	2.0	2.1	2.5	1.8	1.0	1.9	-0.4	1.9	-0.7	1.8	2.1
Intelligence (Savage-Jansen 2018)	1.6	4.8	9.2	-2.3	-1.3	-1.6	-0.8	-2.2	-2.8	-2.7	-2.7	-1.0	-2.4	-0.9	-2.8	-3.0
Smoking Status	1.6	3.8	6.4	-1.9	-2.1	-2.5	-2.0	-2.2	-1.8	-1.2	-1.7	-1.8	-2.2	0.8	-2.1	-2.4
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	3.4	1.4	0.9	1.1	1.0	1.3	1.8	1.2	1.3	1.7	1.0	1.1	1.6	1.5
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.0	-1.3	-1.2	-1.1	-1.4	-1.7	-1.5	-1.0	-1.6	-1.3	-1.1	1.6	-0.6	-1.0
Past tobacco smoking	1.6	2.9	5.3	1.5	1.5	1.6	1.1	1.6	1.8	1.4	1.7	2.0	2.0	0.8	2.3	2.2
Breastfed as a baby	1.6	2.0	5.9	1.5	1.0	1.5	2.4	2.0	0.9	1.1	2.0	0.9	1.0	-0.1	0.7	1.5
Diabetes (self-reported)	1.5	2.3	4.6	1.3	1.5	1.8	1.6	2.0	1.8	0.9	1.6	0.7	1.6	0.0	1.5	2.2
Birth weight of first child	1.5	2.7	4.6	1.6	1.3	1.9	2.0	2.1	1.4	1.4	1.8	0.5	2.0	1.0	1.6	1.9
Medication: Seretide 50 evohaler	1.5	1.7	2.8	-1.3	-0.9	-1.3	-1.4	-1.7	-0.9	-1.1	-1.5	-0.6	-1.6	-1.0	-1.6	-1.7
Commuting to job workplace: Public transport	1.5	1.8	2.9	1.2	1.5	1.1	1.7	1.5	1.2	1.4	1.2	1.5	1.5	-1.5	1.1	1.0
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	4.8	-1.5	-0.6	-1.1	-1.3	-1.4	-1.7	-1.8	-2.2	-1.3	-1.1	-0.4	-0.9	-1.3
Supplements: Calcium	1.5	1.6	3.3	1.5	1.4	1.5	1.4	1.8	0.7	1.0	1.5	1.2	1.2	0.2	0.9	1.4
Age when periods started (menarche)	1.4	3.5	8.9	2.0	3.0	2.1	1.1	1.7	1.4	2.0	2.0	1.4	2.3	0.4	1.6	1.8
Medication: Simvastatin	1.4	2.0	3.7	1.5	1.5	1.3	1.3	1.5	1.0	1.6	1.9	0.0	1.4	0.1	1.8	1.9
Happiness	1.4	1.7	2.8	1.3	1.3	1.3	1.7	1.6	1.5	1.0	1.4	1.6	1.1	-0.7	0.7	1.4
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.7	3.2	1.2	1.8	0.9	1.6	1.1	1.0	1.2	1.1	1.7	1.1	0.5	1.6	1.3
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.5	-1.2	-0.6	-1.4	-1.4	-0.8	-1.1	-1.4	-1.1	-1.4	-1.6	-0.7	-1.9	-1.5
Emphysema/chronic bronchitis	1.4	1.6	5.2	-1.4	-1.1	-1.2	-1.1	-1.5	-2.3	-0.9	-1.5	-1.1	-0.9	-0.5	-0.8	-1.3
Age at last live birth	1.4	2.0	3.9	1.2	1.5	0.9	1.8	1.6	1.5	1.2	1.3	2.0	1.5	0.2	1.4	1.3
Irritability	1.4	2.4	4.2	-1.9	-2.1	-1.5	-1.5	-1.8	-1.6	-1.9	-2.1	-0.3	-1.5	-0.3	-1.1	-1.3
Age started oral contraceptive pill	1.4	1.7	3.7	1.3	0.7	1.6	1.2	0.5	1.0	1.6	1.6	0.8	1.7	0.1	1.9	1.4
Alcohol drinker status: Previous	1.4	1.6	3.4	-1.2	-1.5	-1.9	-1.4	-1.5	-0.7	-0.4	-0.9	-0.5	-1.3	-0.7	-1.4	-1.8
Bipolar Disorder (2018)	1.3	2.0	6.2	-1.5	-0.6	-0.6	-1.2	-1.7	-1.4	-2.5	-2.2	-1.5	-1.1	-0.3	-0.9	-1.3
Prostate Cancer	1.3	1.8	4.2	1.3	1.1	1.1	0.9	0.8	1.2	1.7	1.7	-0.2	1.5	1.1	2.0	1.7
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	4.5	-1.7	-1.2	-1.4	-1.1	-1.1	-0.2	-2.1	-1.7	-1.0	-1.3	-0.9	-1.1	-1.2
Hair/balding pattern: Pattern 4	1.3	3.2	6.2	1.5	2.2	2.0	2.3	1.7	1.5	1.0	1.0	1.4	2.2	0.3	2.5	2.2
Knee pain experienced in last month	1.3	2.0	5.5	-1.2	-1.8	-1.4	-2.3	-1.2	-1.7	-0.0	-0.8	-0.7	-1.4	-1.1	-1.6	-1.5
Handedness (chirality/laterality): Left-handed	1.3	1.5	3.2	-1.3	-0.7	-1.1	-0.6	-1.1	-0.8	-1.8	-1.6	-0.1	-1.4	-1.5	-1.4	-1.4
Unable to work because of sickness or disability	1.3	1.6	9.2	-1.1	-0.8	-1.1	-1.5	0.4	0.2	-0.8	-0.6	-1.3	-1.4	-3.0	-1.3	-0.9
Fasting Glucose	1.2	1.5	4.4	-1.0	-1.1	-0.9	-0.7	-0.5	0.4	-1.3	-1.0	-2.1	-1.3	-1.9	-1.5	-0.8
Lung FVC	1.2	6.4	10.3	-2.8	-3.0	-2.9	-2.8	-2.3	-1.9	-2.5	-2.3	-1.5	-3.2	-0.5	-2.7	-3.0
Medication: Co-codamol	1.2	1.4	4.3	-1.3	-1.7	-2.1	-1.6	-1.5	-0.2	-0.1	-0.6	-0.5	-1.4	-0.5	-0.7	-1.0
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	4.3	1.1	0.9	0.9	-0.0	0.6	1.2	1.4	1.2	1.5	1.3	1.2	2.1	1.4
Smoking status: Current	1.2	1.9	4.2	-1.4	-1.7	-1.6	-2.1	-1.6	-1.0	-0.9	-1.5	-0.9	-1.4	-0.1	-1.2	-1.5
Ulcerative Colitis (UC)	1.1	2.0	6.1	-1.4	-0.8	-1.0	-1.0	-1.3	-1.1	-2.1	-1.6	-2.5	-1.5	-1.4	-0.8	-1.0
Reaction Time	1.1	2.1	4.9	1.3	2.2	1.4	1.7	2.2	1.5	0.3	1.2	-0.6	1.2	-1.4	1.1	1.5
Allergy or Eczema	1.1	2.9	7.5	-2.1	-0.3	-1.0	-1.0	-0.5	-0.9	-2.7	-2.1	-2.7	-1.5	-2.2	-1.3	-1.5
Maternal smoking around birth	1.1	1.5	3.7	-1.2	-1.8	-1.3	-1.9	-1.2	0.2	-0.8	-1.0	-0.9	-1.4	-0.6	-1.2	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	4.8	-1.3	-1.5	-1.5	-1.7	-1.5	-2.2	0.1	-0.8	-0.3	-0.7	0.6	-0.7	-0.7
Alzheimer’s Disease (including proxy)	1.0	1.5	3.0	1.3	1.0	1.3	0.7	0.3	-0.0	1.7	1.5	1.3	1.3	1.7	1.2	1.2
Major Depression (MDD)	1.0	1.2	2.7	1.2	1.2	1.6	1.3	1.6	0.5	1.0	1.0	-0.7	1.2	-0.2	0.8	1.1
Lupus	1.0	1.4	3.5	-1.3	-1.1	-1.5	-0.9	-0.5	-0.4	-1.1	-1.0	-0.6	-1.6	-1.4	-1.9	-1.1
BMI	1.0	5.6	13.6	-2.6	-3.7	-2.4	-3.1	-2.4	-0.8	-2.3	-2.2	-1.1	-2.6	-1.2	-2.2	-2.5
Height	1.0	18.9	29.9	4.3	5.4	4.9	4.7	3.9	4.3	3.4	3.7	2.1	5.1	2.0	5.5	5.2
Systolic blood pressure, automated reading	1.0	2.9	5.4	1.7	0.5	1.9	1.0	1.6	1.3	2.0	2.3	0.9	2.0	1.8	1.9	2.2
Medication for hormone replacement therapy	1.0	1.1	2.8	1.4	1.7	1.3	0.8	1.2	0.9	1.3	1.1	0.3	1.1	0.4	0.4	0.9
Current tobacco smoking	1.0	1.6	4.3	-1.2	-1.6	-1.6	-2.1	-1.5	-0.9	-0.4	-1.2	-0.6	-1.4	0.0	-1.3	-1.5
Average weekly fortified wine intake	1.0	1.2	4.6	0.8	1.1	0.9	1.0	0.6	0.1	1.0	0.8	2.1	1.7	0.5	1.0	1.0
Qualifications: A levels/AS levels or equivalent	1.0	2.2	4.3	-1.4	-0.9	-1.2	-0.7	-2.0	-2.0	-1.5	-1.8	-0.4	-0.9	1.4	-1.7	-2.1
Asthma	1.0	2.0	3.8	-1.6	-1.9	-1.8	-1.5	-1.9	-1.9	-0.6	-1.7	-0.2	-1.1	-0.0	-0.7	-1.5
Impedance of arm (left)	1.0	4.6	12.0	2.3	3.5	2.5	3.0	2.3	0.4	1.8	1.2	0.8	2.4	0.1	2.0	2.4
Age at first live birth	1.0	1.8	4.3	1.0	1.7	1.4	2.0	1.3	0.9	0.5	0.7	2.1	1.5	0.7	1.2	1.2
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.1	-1.1	-1.2	-1.2	-1.0	0.2	0.9	-1.2	-0.4	0.6	-1.3	-1.3	-1.4	-1.3
Overall health rating	1.0	2.1	5.5	-1.6	-1.2	-1.6	-2.3	-1.0	-1.3	-0.8	-1.1	-0.7	-2.0	-1.0	-1.6	-1.5
Diabetes diagnosed by doctor	1.0	1.6	4.2	1.0	1.4	1.6	1.1	1.5	1.5	0.5	0.9	0.5	1.3	0.5	1.5	2.0
Asthma (self-reported)	1.0	2.1	3.6	-1.6	-1.6	-1.7	-1.5	-1.9	-1.9	-0.9	-1.8	-0.6	-1.2	-0.3	-1.0	-1.6
Medication: Gliclazide	1.0	1.2	2.2	1.0	0.7	1.1	1.1	0.9	1.1	1.1	1.2	1.5	1.1	-0.0	1.0	1.4
Bipolar Disorder (2011)	0.9	0.8	5.2	-0.9	-0.4	-0.2	-0.4	-0.6	0.0	-2.3	-1.7	-0.4	-0.7	0.1	-0.4	-0.6
Body mass index (BMI)	0.9	3.7	11.3	-2.0	-3.4	-2.1	-2.9	-2.2	-0.4	-1.4	-1.4	0.1	-2.0	-1.0	-1.6	-2.1
Impedance of arm (right)	0.9	4.1	11.2	2.2	3.4	2.4	2.9	2.1	-0.0	1.9	1.1	0.3	2.3	0.2	1.9	2.2
Medication for pain relief, constipation, heartburn	0.9	1.6	5.8	-1.3	-2.4	-2.0	-1.5	-1.0	-1.2	0.7	0.3	-0.5	-1.0	-0.4	-1.0	-1.2
Illnesses of father: None of the above (group 1)	0.9	1.1	2.4	1.3	1.2	1.3	0.9	1.6	1.2	0.7	1.0	0.2	1.0	-0.4	0.9	1.0
Number of self-reported non-cancer illnesses	0.9	1.5	2.3	-1.3	-1.4	-1.3	-1.5	-1.4	-1.5	-1.2	-1.3	-1.0	-1.3	-0.1	-0.9	-1.2
Alcohol drinker status: Never	0.9	1.1	2.6	1.2	1.1	0.7	0.8	0.1	0.8	1.6	1.5	1.4	1.1	0.6	1.1	0.6
Heart disease (siblings)	0.9	1.1	2.8	1.0	0.9	0.7	1.0	0.8	1.7	1.4	1.3	-0.4	1.1	-0.2	1.3	1.1
Bipolar Disorder or Schizophrenia	0.8	1.9	5.3	-1.1	-0.6	-0.3	-0.8	-0.4	-1.2	-2.1	-1.5	-2.3	-1.4	-1.9	-1.4	-1.2
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.7	-1.4	-1.0	-1.2	-0.4	-1.6	-2.2	-1.3	-1.5	-1.4	-1.3	-0.4	-1.4	-1.8
Body Mass Index (BMI) (2010)	0.8	1.1	2.8	-1.0	-0.9	-0.9	-1.0	-1.4	-1.3	-0.5	-1.3	-0.2	-1.0	-0.1	-1.7	-1.3
Hayfever, allergic rhinitis or eczema	0.8	1.8	7.6	-1.5	0.4	-0.5	-0.1	0.4	-0.1	-2.4	-1.6	-2.8	-1.0	-1.6	-0.7	-0.9
Depression (self-reported)	0.8	1.0	2.4	1.3	1.2	1.1	1.6	0.8	0.0	1.3	1.3	-0.0	1.1	-0.2	0.7	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	5.4	1.4	2.3	2.0	1.7	1.9	2.1	0.1	1.2	-0.2	1.4	0.2	1.9	1.9
Standing height	0.8	7.8	14.2	2.8	3.7	3.4	3.8	2.8	2.4	1.8	2.2	0.6	3.2	1.7	3.0	3.1
Number of full brothers	0.8	1.0	2.6	0.8	1.4	0.7	1.0	1.6	1.5	0.2	1.1	-0.2	0.1	-1.3	0.1	0.7
Neck or shoulder pain in last month	0.8	1.2	6.8	-1.0	-1.2	-0.7	-1.2	-0.2	-0.2	-0.9	-0.3	-2.6	-1.1	-1.0	-0.9	-0.8
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.7	-1.0	-1.3	-0.7	-0.7	-0.5	-0.9	-1.0	-0.9	-1.3	-0.8	0.8	-1.7	-0.9
Commuting to job workplace: Walk	0.8	0.9	3.2	1.2	1.8	1.3	1.1	0.6	0.7	0.3	0.4	0.9	1.0	-0.0	0.9	0.6
Eye problems/disorders: Glaucoma	0.8	0.9	3.5	-0.5	-0.0	-0.1	0.3	1.4	1.9	-1.5	0.2	0.3	-0.8	-1.7	-0.8	-0.1
Number of operations (self-reported)	0.8	1.2	3.4	-0.9	-1.6	-0.7	-1.4	-1.9	-0.7	-1.0	-1.3	-0.4	-0.9	-0.8	-0.8	-1.1
Alzheimer’s Disease (in father)	0.7	0.7	3.6	0.6	0.3	0.8	0.8	-0.4	-0.1	0.8	0.2	1.2	1.0	1.9	0.8	0.6
Triglycerides	0.7	1.1	2.4	1.1	0.5	1.1	1.2	0.8	1.5	0.9	1.2	1.5	0.9	0.4	0.9	1.0
Systolic Blood Pressure	0.7	3.7	9.4	1.9	1.7	2.0	0.9	1.5	0.9	2.6	2.1	0.9	2.0	3.1	2.0	2.2
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	3.2	0.9	1.8	1.3	1.2	0.8	0.2	0.3	0.3	0.3	1.2	0.3	1.2	1.3
Townsend deprivation index at recruitment	0.7	1.0	2.5	-0.9	-0.7	-1.2	-1.6	-0.8	-0.2	-0.9	-1.0	-0.2	-1.2	0.1	-1.4	-1.4
Qualifications: CSEs or equivalent	0.7	0.9	2.9	0.8	1.4	0.8	0.8	1.5	0.8	0.6	0.7	-1.7	0.4	0.5	0.1	0.6
Multivitamins +/- minerals	0.7	0.9	2.7	0.9	1.6	1.3	1.3	0.8	1.1	0.6	0.8	0.3	1.1	0.5	0.1	1.0
Nervous feelings	0.7	1.3	6.8	-0.9	-0.8	-1.0	-1.1	-2.6	-1.5	0.3	-1.1	0.4	-0.3	1.7	0.3	-0.4
Allergy	0.7	1.6	4.8	1.6	0.3	0.7	0.4	0.5	1.0	1.8	2.1	2.2	0.8	1.0	0.5	1.1
Mouth/teeth dental problems: Dentures	0.7	1.2	6.1	-0.9	-0.1	-0.8	-1.1	-0.6	-0.3	-0.9	-0.9	0.1	-1.3	-2.5	-1.3	-1.1
Medication: Cholesterol lowering	0.7	1.1	2.6	1.0	0.9	1.2	0.4	0.9	-0.1	1.1	1.0	1.3	1.3	-0.1	1.6	1.4
Tense / ‘highly strung’	0.7	1.2	5.5	-0.4	-0.6	-0.0	-0.5	-1.3	-0.3	-0.1	-1.0	2.3	0.7	1.9	1.2	0.7
Leg fat percentage (right)	0.7	2.6	7.6	-1.4	-2.8	-1.6	-2.5	-2.1	-0.9	-0.5	-1.0	1.1	-1.5	-1.2	-1.0	-1.5
Pulse wave peak to peak time	0.7	0.8	3.5	0.8	1.9	1.2	1.5	0.7	0.5	0.1	0.1	-0.7	0.8	0.6	0.5	0.5
Comparative height size at age 10	0.7	4.0	6.9	2.1	1.3	2.5	2.0	1.4	1.4	2.2	2.1	1.0	2.6	1.5	2.6	2.5
Illnesses of siblings: Diabetes	0.7	0.9	4.0	0.8	1.1	0.4	-0.3	-0.1	-0.4	1.8	1.0	-0.1	0.5	2.0	0.5	0.3
Neuroticism (Nagel 2018)	0.6	1.3	4.5	-0.7	-1.4	-1.0	-1.4	-2.1	-1.9	-0.0	-0.9	0.8	-0.5	1.3	-0.2	-0.5
Crohns Disease (2017)	0.6	1.4	5.4	1.3	2.3	1.3	0.5	0.7	0.8	0.8	1.0	-1.6	0.8	0.4	1.0	1.3
LDL Cholesterol	0.6	1.0	3.3	0.6	1.0	0.7	1.0	-0.2	0.5	0.9	0.5	1.2	1.0	1.8	1.3	0.9
Neuroticism (2016)	0.6	0.8	2.8	0.8	-0.5	0.4	0.5	0.4	0.3	1.7	1.0	1.5	0.8	1.3	0.7	0.6
Rheumatoid Arthritis	0.6	0.8	2.0	-0.8	-0.9	-0.5	-1.0	-1.2	-1.4	-0.9	-1.0	-0.6	-0.6	0.6	-0.8	-0.7
Schizophrenia (2014)	0.6	1.4	9.9	-0.4	-0.0	0.1	0.4	0.9	0.1	-1.1	-0.3	-2.2	-0.8	-3.1	-0.7	-0.5
Ulcerative Colitis	0.6	0.9	2.8	-0.9	-0.1	-0.6	-0.4	-0.4	-0.6	-1.5	-1.0	-1.7	-1.0	-1.2	-0.7	-0.7
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.3	-0.3	-0.3	-0.6	-0.7	-1.3	-1.5	0.8	-0.5	1.8	0.1	1.3	0.4	-0.1
Medication: Metformin	0.6	0.8	2.3	0.5	0.6	1.0	1.1	1.3	1.5	-0.5	0.2	0.7	0.7	-0.1	0.8	1.4
Hand grip strength (right)	0.6	1.6	4.6	1.1	1.7	1.5	2.1	1.6	1.4	0.5	1.2	0.5	1.1	-0.2	0.5	1.3
Fed-up feelings	0.6	1.0	2.3	-1.2	-1.2	-1.2	-1.3	-1.1	-0.6	-0.8	-1.0	1.5	-0.8	0.3	-0.6	-0.8
Relative age voice broke	0.6	1.0	2.4	1.1	1.3	1.0	1.6	1.0	0.3	0.7	0.9	-0.1	0.9	0.1	1.4	0.9
Medication: Ramipril	0.6	0.7	1.6	0.9	1.2	1.2	1.1	1.3	0.2	0.5	0.7	0.5	0.5	0.4	0.8	0.6
Prospective memory result	0.6	0.7	1.4	-0.9	-1.0	-1.0	-0.7	-1.0	-1.0	-0.9	-1.2	-0.4	-0.8	-0.1	-0.6	-0.9
Pulse wave reflection index	0.6	0.8	2.9	0.1	-1.4	-0.6	-0.7	0.1	0.6	1.4	1.0	1.7	0.3	-0.2	0.7	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.9	0.9	1.0	0.5	0.6	0.5	0.9	1.4	1.4	0.7	0.5	-1.2	-0.3	0.1
Medication: Ibuprofen	0.6	0.7	2.7	0.8	1.6	1.1	1.3	0.7	0.3	0.2	-0.2	0.9	0.8	0.4	0.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.4	1.1	1.0	1.1	1.8	1.3	0.6	1.0	1.1	0.5	1.1	0.4	0.9	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.7	0.9	0.3	0.7	0.6	0.1	0.7	1.2	1.1	1.6	0.7	0.3	0.4	0.4
Medication for cholesterol	0.6	0.9	4.0	-1.1	-1.1	-0.6	0.0	-0.6	-0.7	-2.0	-1.6	0.4	-0.5	-0.2	-0.1	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	4.0	-0.7	0.1	-0.6	-0.5	-0.7	0.1	-0.9	-0.9	-2.0	-1.0	-0.0	-0.6	-0.5
Leg fat percentage (left)	0.6	2.2	6.6	-1.3	-2.6	-1.4	-2.4	-1.8	-0.6	-0.5	-0.8	1.1	-1.3	-1.6	-0.8	-1.3
Average weekly beer plus cider intake	0.6	0.9	2.0	-0.9	-1.4	-1.0	-1.2	-0.5	-1.4	-0.6	-0.7	-0.9	-1.1	-0.9	-0.6	-0.9
Cholesterol lowering medication	0.6	0.8	1.9	1.1	1.3	0.6	0.4	0.6	1.1	1.4	1.3	-0.9	0.3	0.6	0.4	0.9
Pain experienced in last month	0.6	1.1	2.2	1.1	1.2	0.8	1.5	1.2	0.6	1.0	1.0	0.8	0.8	1.3	0.8	1.0
Depressed Affect (Nagel 2018)	0.5	0.9	2.2	-0.8	-1.2	-1.0	-1.5	-1.5	-1.2	-0.1	-0.6	1.2	-0.7	0.6	-0.5	-0.7
Depression (Nagel 2018)	0.5	0.7	3.4	-0.7	-0.8	-1.1	-0.8	-1.0	-1.8	0.6	-0.3	0.5	-0.4	1.0	-0.4	-0.4
Worry (Nagel 2018)	0.5	1.0	4.1	-0.4	-0.7	-0.5	-0.8	-2.0	-1.7	0.1	-0.9	1.0	-0.0	1.6	0.6	0.3
Pack years adult smoking proportion	0.5	0.8	1.8	-0.6	-1.3	-0.9	-1.3	-0.8	0.1	-0.1	-0.3	0.8	-0.9	-0.6	-1.2	-1.0
Medication: Atenolol	0.5	0.6	2.1	0.6	0.6	0.2	0.2	0.7	0.2	1.1	1.3	1.4	0.2	0.2	0.6	0.8
High blood pressure (mother)	0.5	0.8	3.4	1.0	0.8	0.2	0.9	0.6	-0.0	1.2	1.4	-0.1	0.4	1.9	0.0	0.2
Number of incorrect matches in round	0.5	0.8	3.8	0.0	-1.0	-0.4	-0.3	-0.9	-1.5	0.8	0.4	0.5	0.4	1.9	1.1	0.7
Mouth/teeth dental problems	0.5	0.7	2.5	0.2	-0.9	-0.2	-0.6	-0.6	-1.3	0.9	0.5	-1.4	0.4	1.6	0.8	0.2
Heart attack	0.5	0.6	1.4	1.0	0.3	0.8	0.6	0.7	0.7	1.1	0.7	1.2	0.7	-0.2	0.8	0.7
Father’s age at death	0.5	0.6	2.1	0.8	1.0	0.9	1.5	0.8	-0.3	0.9	0.7	0.4	0.9	0.3	0.6	0.6
Worrier / anxious feelings	0.5	1.0	3.3	0.6	0.3	0.7	0.5	-0.9	-0.5	0.7	0.1	1.8	0.9	1.8	1.3	0.9
Pulse wave Arterial Stiffness index	0.5	0.6	2.7	-0.7	-1.6	-1.1	-1.3	-0.5	-0.4	-0.1	0.0	0.6	-0.7	-0.6	-0.4	-0.4
Exposure to tobacco smoke at home	0.5	0.5	1.9	0.7	0.9	0.9	0.4	1.0	0.6	0.1	0.4	-0.2	0.6	-1.4	0.4	0.9
Headache pain in last month	0.5	0.8	1.9	-1.0	0.0	-0.9	-1.4	-1.0	-0.8	-0.7	-1.3	-1.1	-0.7	0.1	-0.6	-0.9
Glaucoma (self-reported)	0.5	0.6	2.3	-0.0	0.9	0.5	0.5	1.2	1.5	-0.9	0.3	0.6	-0.1	-1.2	0.1	0.2
Eye problems/disorders: None of the above	0.5	0.6	1.8	0.9	0.1	0.7	0.1	-0.1	-0.5	1.4	0.7	-0.9	0.9	0.6	0.9	0.7
Migraine (self-reported)	0.5	0.6	1.5	-0.7	-0.2	-0.3	-0.8	-1.2	-1.2	-0.9	-1.1	-0.5	-0.6	0.8	-0.5	-0.6
Suffer from ‘nerves’	0.5	0.7	3.5	-0.0	-0.2	0.1	0.2	-1.5	-0.6	0.9	-0.2	1.0	0.5	1.9	0.9	0.6
Supplements: Vitamin C	0.5	0.5	3.0	0.1	0.2	0.1	0.2	0.9	0.6	-0.7	0.1	-0.7	-0.3	-1.7	-1.2	-0.5
Eye problems/disorders: Cataract	0.5	0.6	1.0	0.4	0.9	1.0	0.6	1.0	0.6	0.3	0.2	1.0	1.0	0.0	0.9	0.7
Breast cancer (self-reported)	0.5	0.6	3.7	0.5	0.7	0.6	0.7	1.1	0.1	0.2	1.0	0.3	0.3	-1.9	0.1	0.7
Financial situation satisfaction	0.5	0.7	5.5	-0.3	-0.3	-0.1	-0.7	1.0	0.9	-0.5	0.2	-0.1	-0.3	-2.3	-0.2	0.2
Medication: Atorvastatin	0.5	0.6	1.8	-0.6	-0.2	-0.7	-0.4	-0.6	-0.9	-0.5	-0.7	-1.3	-0.8	-0.3	-1.0	-1.1
Pack years of smoking	0.5	0.7	2.1	-0.5	-1.4	-0.9	-1.2	-0.8	0.2	0.0	-0.2	0.9	-0.9	-0.5	-1.1	-1.0
Impedance of whole body	0.5	2.8	9.7	1.8	3.1	1.9	2.1	1.8	0.0	1.4	0.9	0.7	1.8	-0.4	1.3	1.8
Schizophrenia (2018)	0.4	0.9	5.3	-0.2	-0.3	0.1	-0.1	0.8	-0.3	-0.7	-0.2	-1.8	-0.9	-2.3	-1.0	-0.5
Schizophrenia vs Biploar Disorder	0.4	0.5	2.4	-0.1	-0.8	-0.4	-0.3	0.4	-0.9	0.9	0.6	-0.8	-0.4	-1.6	0.0	0.1
Crohns Disease (2012)	0.4	0.6	2.8	0.8	1.7	0.7	0.4	0.3	0.3	0.6	0.7	-1.2	0.6	0.4	0.8	0.8
Respiratory disease	0.4	0.8	1.3	-0.9	-1.0	-1.0	-0.7	-1.1	-1.1	-0.5	-1.2	-0.1	-0.7	-0.7	-0.8	-1.1
Chronotype (morning person)	0.4	0.9	3.2	-1.0	-0.8	-0.6	-1.1	-0.5	-0.5	-1.3	-0.7	-1.3	-0.6	-1.8	-0.7	-0.6
Hand grip strength (left)	0.4	0.9	3.4	0.5	1.1	0.8	1.9	1.6	1.2	0.2	1.0	1.0	0.5	-0.4	0.1	0.7
Ever had hysterectomy (womb removed)	0.4	0.5	2.2	-0.3	-0.8	-0.2	-0.7	-1.5	-0.9	-0.0	-0.7	-0.7	-0.5	-0.2	-0.2	-0.7
Diabetes (father)	0.4	0.5	2.6	-0.8	0.2	-0.0	-0.3	-0.1	0.2	-1.3	-1.1	-1.6	0.0	-0.3	0.5	0.6
Fluid intelligence score	0.4	0.9	3.4	-0.9	-0.8	-1.0	-0.3	-1.1	-1.9	-0.3	-0.6	-1.2	-0.7	-0.3	-0.7	-1.2
Neuroticism score	0.4	0.9	4.3	-0.3	-0.9	-0.4	-0.9	-1.6	-1.1	0.7	-0.4	2.1	0.2	1.0	0.7	0.2
Pulse rate	0.4	0.7	1.8	-0.9	-0.4	-0.6	-0.8	-0.6	-0.2	-0.8	-1.1	0.1	-1.0	-0.2	-1.3	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	2.6	0.6	1.6	0.9	1.0	0.8	0.7	-0.4	-0.5	0.7	0.1	0.5	-0.5	-0.1
Length of working week for main job	0.4	0.5	1.4	0.5	0.0	0.5	1.0	0.8	1.2	-0.2	0.4	0.0	0.7	-0.8	0.7	0.9
Body fat percentage	0.4	1.4	5.2	-1.0	-2.3	-1.0	-1.7	-1.3	-0.4	-0.5	-0.7	1.1	-0.9	-1.5	-0.5	-0.9
Worry too long after embarrassment	0.4	0.7	2.8	-0.5	-1.0	-0.8	-0.7	-1.7	-1.5	-0.1	-0.6	-0.2	-0.5	0.7	-0.3	-0.4
Qualifications: College or University degree	0.4	1.4	4.1	-1.1	-0.6	-0.7	-0.1	-2.0	-2.0	-1.4	-1.6	-0.3	-0.6	1.1	-0.8	-1.1
Leg fat mass (right)	0.4	1.5	6.2	-1.2	-2.5	-1.2	-1.9	-1.5	-0.1	-0.5	-0.7	0.8	-1.1	-1.0	-0.5	-1.1
Number of full sisters	0.4	0.5	4.4	-0.2	0.7	0.3	0.2	0.5	0.1	-0.4	-0.4	-0.4	-0.5	-2.1	-0.4	-0.5
Mood swings	0.4	0.8	4.2	-0.4	-0.6	-0.5	-0.6	-1.3	-1.0	0.3	-0.4	2.0	-0.1	1.3	-0.3	-0.3
Ever had bowel cancer screening	0.4	0.5	1.1	-0.6	-0.8	-0.7	-0.3	-0.8	-0.8	-0.3	-0.4	-0.5	-0.7	-1.1	-0.6	-0.8
Osteoarthritis (self-reported)	0.4	0.5	1.4	-0.6	-1.2	-0.5	-0.9	-0.7	-0.7	-0.2	-0.4	-1.1	-0.5	-0.9	-0.3	-0.3
Average weekly champagne plus white wine intake	0.4	0.6	2.1	0.7	1.2	1.1	1.4	0.6	-1.2	0.1	0.1	-0.3	0.6	-0.3	-0.2	0.3
Miserableness	0.4	0.6	4.2	-0.2	-0.1	-0.6	-0.8	-1.0	-0.2	0.5	-0.3	2.1	-0.1	1.0	0.3	-0.4
Hearing aid user	0.4	0.5	2.7	-0.0	0.1	0.7	0.5	0.7	0.4	-1.1	-0.3	-0.2	0.7	-1.6	0.5	0.4
Diastolic blood pressure, automated reading	0.4	1.2	2.7	1.2	0.4	1.6	0.4	1.0	1.2	0.9	1.2	0.8	1.4	1.0	1.2	1.3
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.4	1.0	0.2	0.7	0.4	0.8	0.7	1.1	0.8	1.2	0.5	-0.2	0.6	0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.5	0.6	1.2	0.7	0.8	1.1	1.0	0.1	-0.1	0.3	0.8	0.9	0.4	0.3
Alzheimer’s Disease (in mother)	0.3	0.3	1.6	-0.1	0.2	0.1	-0.2	-0.4	-1.2	0.2	-0.1	-0.0	-0.3	1.3	-0.6	-0.4
Irritable Bowel Disease (IBD)	0.3	0.7	5.8	-0.2	0.9	0.0	-0.5	-0.6	-0.2	-0.9	-0.6	-2.4	-0.5	-0.3	0.1	0.0
Waist Hip Ratio (WHR)	0.3	1.2	10.2	0.5	1.6	0.5	0.5	-0.1	-0.2	0.4	-0.0	0.2	0.7	3.2	0.8	0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.7	0.4	0.6	0.9	0.4	1.0	0.4	0.3	0.3	-0.1	0.8	0.9	1.0	1.3
Neuroticism	0.3	0.7	2.4	-0.4	-1.1	-0.6	-1.2	-1.5	-1.4	0.4	-0.6	0.6	-0.2	0.5	0.3	-0.1
Relative age of first facial hair	0.3	0.6	2.2	0.9	1.0	0.9	0.7	0.7	0.4	0.3	0.6	0.5	0.5	0.1	1.5	0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	2.4	0.5	-0.1	0.4	-0.6	-0.2	-0.2	0.6	0.7	-0.7	0.1	-1.5	-0.6	-0.2
Angina	0.3	0.4	2.4	-0.1	-0.3	-0.1	-0.3	0.7	0.9	-0.2	0.4	0.6	-0.3	-1.6	0.1	-0.1
Alcohol usually taken with meals	0.3	0.4	2.3	0.5	0.9	0.9	0.8	0.2	-0.6	-0.1	0.2	1.5	0.5	0.3	-0.2	0.2
Hair/balding pattern: Pattern 2	0.3	0.4	2.4	0.2	0.1	-0.3	0.2	0.1	0.7	-0.1	0.5	-1.6	-0.6	-1.1	-0.7	-0.1
Had menopause	0.3	0.4	1.4	0.5	-0.0	0.5	-0.5	0.5	-0.4	1.2	0.9	-1.0	0.3	-0.7	0.3	0.6
Had other major operations	0.3	0.4	0.8	-0.4	-0.7	-0.4	-0.5	-0.8	-0.4	-0.7	-0.6	-0.2	-0.8	-0.5	-0.7	-0.9
Qualifications: None of the above	0.3	0.6	1.9	0.5	-0.6	0.1	-0.4	1.3	1.0	0.8	1.4	-0.3	-0.1	-1.0	-0.1	0.6
Financial difficulties in last 2 years	0.3	0.3	2.5	-0.1	-0.2	-0.2	-0.6	-0.4	-0.1	0.2	0.1	1.6	-0.2	-1.0	-0.3	-0.4
Pain all over the body in last month	0.3	0.3	2.3	0.2	0.3	0.4	-0.3	-0.2	0.6	0.3	0.1	1.5	0.5	-0.1	0.8	0.1
Arm fat percentage (right)	0.3	1.1	4.9	-0.9	-2.2	-0.9	-1.6	-1.3	-0.1	-0.4	-0.7	0.9	-0.8	-0.7	-0.4	-0.9
Time employed in main current job	0.3	0.4	0.8	-0.7	-0.8	-0.4	-0.5	-0.6	-0.9	-0.3	-0.6	-0.3	-0.6	0.1	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.9	0.9	1.4	1.3	1.2	1.0	1.4	0.1	0.8	0.0	0.8	0.5	1.4	1.1
Noisy workplace	0.3	0.4	2.6	0.3	-0.2	-0.1	-0.6	-0.0	-0.6	1.1	0.3	1.6	0.3	-0.6	0.1	-0.2
Illnesses of mother	0.3	0.3	1.5	-0.1	-1.0	0.2	-0.4	-0.7	-0.4	0.1	-0.3	1.2	0.5	-0.4	0.6	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.2	0.5	0.5	0.5	0.2	0.4	0.9	-0.2	0.4	1.1	0.5	-1.1	0.3	0.3
Loud music exposure frequency	0.3	0.3	1.5	0.1	-0.5	-0.2	-0.7	0.4	0.8	0.0	0.6	0.5	-0.3	-1.2	-0.5	-0.3
Medication: Paracetamol	0.3	0.4	1.5	0.6	0.7	1.2	0.2	0.2	0.8	-0.6	-0.4	0.3	0.9	-0.1	0.8	0.7
Number of children fathered	0.3	0.3	2.4	-0.3	0.2	-0.0	0.2	-0.1	-0.5	-1.6	-0.7	0.5	-0.1	-0.0	-0.5	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.6	0.3	-0.4	-0.1	0.2	-0.5	0.5	1.3	0.3	-0.3	0.6	1.1	0.9	0.2
Had major operations	0.3	0.4	1.4	-0.3	-0.9	0.1	-0.6	-0.7	-0.7	-0.4	-0.8	1.2	0.0	-0.6	-0.2	-0.5
Family relationship satisfaction	0.3	0.3	1.0	-0.6	-0.5	-0.7	-0.5	-0.6	-1.0	-0.5	-0.8	-0.3	-0.4	0.3	-0.3	-0.4
Smoking status: Previous	0.3	0.5	2.1	-0.0	-0.5	-0.4	0.1	-0.5	-0.8	-0.0	-0.1	-1.4	-0.7	-0.3	-1.1	-0.9
Arm fat percentage (left)	0.3	1.1	4.9	-0.8	-2.2	-0.8	-1.5	-1.2	-0.1	-0.3	-0.6	1.0	-0.8	-0.8	-0.3	-0.8
Loneliness, isolation	0.3	0.3	1.5	0.4	-0.5	0.1	-0.7	0.1	0.4	0.7	0.5	1.0	0.2	-1.2	-0.1	0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.2	0.3	1.1	0.7	1.1	0.8	1.0	-0.1	0.1	0.8	0.1	0.1	0.0	0.1
Mineral and other dietary supplements	0.3	0.4	1.8	-0.1	-0.4	-0.3	-0.6	-0.6	-0.9	0.5	-0.4	-0.7	0.2	1.3	0.9	0.2
Mother’s age at death	0.3	0.3	1.5	0.5	1.0	0.7	1.2	0.6	-0.2	-0.4	-0.2	0.3	0.4	-0.4	0.3	0.1
Medication: Blood pressure	0.3	0.6	1.4	-0.8	-0.8	-1.0	-1.1	-1.2	-0.8	0.5	-0.1	-0.9	-1.0	-0.0	-0.8	-0.5
Medication: Bendroflumethiazide	0.3	0.5	2.7	0.4	0.0	0.0	-0.2	-0.6	-0.9	1.2	0.4	0.1	0.2	1.6	0.3	0.5
Medication: Paracetamol	0.3	0.5	1.9	-0.4	-0.0	0.3	-0.8	-0.6	0.2	-1.4	-1.4	-0.8	-0.1	-0.9	-0.2	-0.4
Medication: Lisinopril	0.3	0.4	2.5	0.8	-0.2	0.2	-0.4	0.6	-0.0	1.6	1.0	0.4	0.2	0.0	0.1	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.3	-0.0	0.3	-0.1	0.6	0.5	0.4	-1.1	-0.5	0.3	-0.4	-1.1	-0.6	-0.3
Myopia	0.3	0.4	1.3	-0.4	-0.6	-0.5	-0.2	-0.2	-0.7	-0.4	-0.3	-0.2	-0.6	-1.1	-0.8	-0.9
Leg fat mass (left)	0.3	1.3	5.2	-1.0	-2.3	-1.0	-1.8	-1.2	0.2	-0.5	-0.5	0.8	-0.9	-1.3	-0.4	-0.9
Age at First Birth	0.2	0.4	2.3	0.5	-0.1	0.9	0.0	0.0	-0.0	0.5	0.2	0.4	0.9	1.5	0.3	0.0
Coronary Artery Disease (CAD)	0.2	0.2	1.1	0.5	0.4	0.3	0.1	-0.0	0.2	1.1	0.4	-0.4	0.3	0.6	-0.1	0.3
HDL Cholesterol	0.2	0.4	1.8	-0.7	-0.3	-0.6	-0.6	-0.4	-0.0	-0.6	-0.5	0.7	-0.5	-1.3	-0.6	-0.4
Primary Biliary Cirrhosis	0.2	0.2	2.2	0.2	-0.4	-0.0	-0.1	-0.3	-0.1	0.5	0.4	1.5	0.0	0.0	0.2	0.1
Blood Red Count	0.2	2.2	14.4	-0.4	0.5	0.3	0.4	1.5	1.2	-2.3	-1.0	-0.7	-0.8	-3.8	-1.3	-0.9
Hypothyroidism (self reported)	0.2	0.5	1.8	-0.7	-0.5	-0.5	-1.3	0.1	-0.5	-1.1	-0.5	-0.6	-0.5	-1.0	-0.5	-0.3
Sensitivity / hurt feelings	0.2	0.4	2.5	-0.1	-0.4	-0.4	-0.5	-1.0	-0.6	0.8	0.3	1.6	-0.1	0.2	-0.5	-0.4
Hearing difficulty/problems: Yes	0.2	0.3	1.8	-0.0	-0.1	0.6	0.5	0.6	-0.1	-0.6	-0.2	-1.3	0.6	0.0	0.5	0.6
Supplements: Zinc	0.2	0.2	0.6	-0.0	-0.5	-0.4	0.2	0.1	0.2	-0.7	0.1	-0.8	-0.3	0.3	-0.8	-0.2
Diabetes (mother)	0.2	0.3	2.0	0.2	-0.2	-0.1	-0.1	0.0	0.6	0.8	-0.1	1.4	0.2	0.4	0.8	0.1
Trunk fat percentage	0.2	0.8	3.3	-0.7	-1.8	-0.5	-1.1	-0.9	-0.2	-0.2	-0.4	0.9	-0.5	-1.4	-0.3	-0.6
Serious illness, injury or assault to yourself	0.2	0.3	0.9	0.5	0.6	0.2	0.6	0.2	-0.1	0.9	0.8	0.1	0.5	-0.4	0.7	0.4
Supplements: Glucosamine	0.2	0.2	1.1	-0.1	-0.1	0.2	0.4	0.2	0.0	-0.7	-0.2	-0.5	-0.2	-1.0	-0.6	-0.3
Medication: Levothyroxine sodium	0.2	0.3	2.6	-0.1	0.5	0.1	-0.4	0.3	0.3	-0.4	-0.6	0.5	-0.2	-1.6	-0.3	-0.2
Chronic bronchitis/emphysema (father)	0.2	0.2	0.7	0.3	0.0	-0.2	-0.0	-0.3	-0.6	0.7	0.7	0.8	-0.1	0.4	-0.0	-0.4
Impedance of leg (left)	0.2	1.0	5.3	1.0	2.3	0.9	1.1	1.0	-0.2	0.7	0.5	0.5	0.9	-1.0	0.5	1.0
Hearing difficulty/problems with background noise	0.2	0.3	1.1	0.3	-0.1	0.5	0.2	0.9	-0.1	0.2	0.7	-1.1	0.6	0.2	0.5	0.8
Illnesses of siblings	0.2	0.3	1.4	-0.5	-0.6	-0.2	0.1	0.5	-0.5	-1.2	-0.7	0.1	-0.3	-0.5	-0.6	-0.1
Hip circumference	0.2	0.9	3.9	-0.9	-2.0	-0.7	-1.4	-0.9	-0.0	-0.8	-0.6	-0.4	-0.9	-0.8	-0.6	-1.0
Alcohol intake versus 10 years previously	0.2	0.4	1.3	-0.6	-0.4	-0.3	-0.6	0.7	0.2	-0.8	-0.7	0.1	-0.3	-1.1	-0.5	-0.7
Number of live births	0.2	0.3	1.1	-0.3	-0.5	-0.4	-0.9	-0.8	-1.1	0.4	-0.1	0.4	-0.3	-0.1	-0.5	-0.7
Lung cancer (father)	0.2	0.3	2.0	-0.1	-0.2	0.1	-0.0	-0.1	-1.1	0.4	-0.2	0.2	0.2	1.4	-0.1	-0.1
Arm fat mass (right)	0.2	0.7	3.6	-0.7	-1.9	-0.6	-1.3	-1.0	0.4	-0.4	-0.5	0.5	-0.7	-0.6	-0.2	-0.7
Trunk predicted mass	0.2	0.9	4.6	0.6	0.4	0.8	0.8	0.6	2.1	0.3	0.9	0.3	0.7	1.3	1.0	0.7
Peak expiratory flow (PEF)	0.2	0.4	2.0	0.5	0.4	0.3	0.5	-0.3	0.5	0.2	0.4	1.2	0.1	1.4	0.1	0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.8	0.1	0.4	0.1	0.6	0.6	0.6	0.1	-0.0	-0.6	-0.2	0.9	-0.5	-0.1
Blood clot in the leg (DVT)	0.2	0.3	1.0	0.3	1.0	0.4	0.6	0.8	0.7	0.0	-0.3	0.5	0.6	0.8	0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	-0.5	-0.6	-0.7	-0.1	-0.3	0.8	-0.3	-0.2	-0.3	-0.6	-0.3	-0.9	-0.7
Birth weight	0.2	0.5	1.5	0.4	1.0	0.4	0.2	0.8	1.2	-0.3	0.8	-0.2	0.3	1.2	0.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	0.5	0.2	0.2	-0.4	0.1	0.8	0.4	0.7	-0.1	0.5	-0.5	0.5	0.5
Medication: Blood pressure	0.2	0.4	1.6	0.4	0.3	0.7	-0.1	0.2	-0.2	0.2	0.1	0.6	0.4	1.3	1.0	0.8
Angina (self-reported)	0.2	0.3	1.5	0.1	0.0	0.1	0.1	0.8	0.9	0.0	0.5	0.7	0.0	-1.2	0.4	0.1
Medication: Allopurinol	0.2	0.3	1.4	-0.1	-0.8	-0.2	-0.8	-0.2	0.4	-0.1	0.2	0.3	-0.8	-1.2	-0.6	-0.2
Whole body fat mass	0.2	0.7	3.3	-0.6	-1.8	-0.5	-1.1	-0.9	0.3	-0.3	-0.3	0.9	-0.5	-0.9	-0.1	-0.5
Leg pain on walking	0.2	0.2	1.4	0.0	-0.4	-0.1	-0.4	-0.4	0.8	-0.2	-0.2	1.2	-0.5	-0.2	0.4	0.3
Illnesses of father: Heart disease	0.2	0.3	1.1	-0.3	-0.9	-0.6	-0.7	-1.1	-0.6	0.2	0.1	0.7	-0.3	0.5	-0.5	-0.6
Average weekly red wine intake	0.2	0.3	1.3	0.3	0.6	0.3	0.9	-0.0	0.0	0.5	0.1	1.1	0.4	0.4	0.1	0.4
Long-standing illness, disability or infirmity	0.2	0.3	1.0	-0.6	0.2	-0.4	-1.0	-0.1	-0.2	-0.6	-0.7	-0.6	-0.8	-0.5	-0.8	-0.4
Qualifications: nursing, teaching	0.2	0.3	1.5	-0.3	-0.0	0.3	0.2	-0.2	-0.5	-1.2	-0.9	0.6	0.3	0.8	0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.5	0.5	0.8	0.6	0.2	1.0	1.2	-0.3	0.7	-0.2	0.4	-0.4	0.7	0.9
Arm fat mass (left)	0.2	0.8	4.0	-0.7	-2.0	-0.6	-1.4	-1.0	0.4	-0.4	-0.4	0.7	-0.7	-0.4	-0.3	-0.7
Wears glasses or contact lenses	0.2	0.2	1.1	-0.2	-0.2	-0.1	-0.4	0.3	1.1	-0.3	-0.1	0.1	-0.2	-0.9	0.0	0.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.3	-0.0	0.6	-0.4	0.1	0.1	0.4	-0.4	0.2	-1.1	-0.6	-0.1	-0.7	-0.5
Risk taking	0.2	0.2	1.1	-0.5	-0.5	-0.1	-0.4	0.2	-0.1	-0.5	0.2	1.0	-0.1	-0.5	-0.8	-0.4
Ever depressed for a whole week	0.2	0.2	0.8	-0.4	0.1	-0.2	-0.2	-0.0	-0.8	-0.4	-0.3	0.3	-0.4	-0.1	-0.9	-0.8
Ovarian Cancer	0.1	0.2	0.6	0.1	-0.3	0.3	0.1	0.8	0.4	0.5	0.3	-0.8	0.3	0.1	0.1	0.4
Mean Putamen Volume	0.1	0.1	0.3	-0.5	0.4	-0.1	-0.0	-0.5	-0.5	-0.5	-0.5	-0.4	-0.1	0.4	0.0	0.1
HbA1C	0.1	0.2	0.6	-0.1	-0.2	-0.0	0.1	-0.5	0.1	0.0	-0.5	-0.4	-0.4	0.6	-0.8	-0.5
Blood Eosinophil Count	0.1	0.9	6.4	0.2	0.6	0.7	0.2	1.2	1.4	-0.7	-0.1	-0.4	-0.2	-2.5	0.3	0.3
Blood White Count	0.1	0.5	1.0	-0.8	-0.9	-0.9	-0.8	-0.1	0.0	-1.0	-0.8	-0.4	-1.0	-0.7	0.1	-0.5
Heel T-Score	0.1	1.2	7.4	-0.9	-0.5	-0.6	0.1	0.2	0.2	-1.6	-0.7	-2.7	-0.9	-1.2	-0.9	-0.4
Cardiovascular Disease	0.1	0.4	2.6	0.2	0.8	-0.0	-0.4	-0.4	-0.5	0.0	-0.1	-1.6	-0.3	1.2	0.1	0.2
Hair Pigment	0.1	1.7	4.9	-1.1	-1.7	-1.2	-1.2	-1.1	-2.2	-1.5	-1.0	-1.4	-0.9	-0.7	-0.9	-1.2
Number of treatments/medications taken	0.1	0.3	1.7	0.1	0.5	0.4	0.3	0.4	0.7	-0.5	-0.1	-0.3	-0.2	-1.3	-0.5	-0.1
Severe depression (siblings)	0.1	0.1	0.4	-0.3	-0.4	-0.3	-0.7	-0.2	-0.6	0.3	-0.6	-0.2	0.1	0.1	0.3	-0.2
Impedance of leg (right)	0.1	0.5	3.3	0.6	1.8	0.4	0.7	0.4	-0.6	0.5	0.1	0.1	0.4	-0.5	-0.0	0.6
Leg fat-free mass (left)	0.1	0.3	1.7	-0.1	-0.8	0.1	-0.0	0.0	1.3	0.1	0.3	0.2	0.2	0.7	0.6	0.1
Taking other prescription medications	0.1	0.2	0.6	0.2	0.7	0.6	0.4	0.7	0.3	0.0	-0.1	-0.1	0.4	-0.7	0.5	0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.8	-0.0	-0.5	-0.3	-0.0	-0.5	-0.5	0.2	-0.1	-0.1	-0.2	-0.9	0.1	-0.2
High blood pressure	0.1	0.4	1.3	0.2	-0.3	0.1	-0.5	-0.3	-0.4	1.1	0.5	-0.4	0.2	1.1	0.7	0.9
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.6	0.4	-0.3	0.3	-0.1	0.7	-0.1	0.1	0.3	-0.3	0.3	-0.8	0.3	0.6
Leg predicted mass (left)	0.1	0.3	2.0	-0.1	-0.8	0.2	0.1	0.1	1.4	0.1	0.3	0.2	0.2	0.5	0.6	0.1
Trunk fat mass	0.1	0.5	2.7	-0.5	-1.6	-0.4	-0.8	-0.6	0.3	-0.3	-0.2	0.9	-0.3	-1.1	-0.0	-0.4
Waist circumference	0.1	0.3	1.2	-0.4	-1.1	-0.2	-0.8	-0.6	0.4	-0.3	-0.3	0.4	-0.3	0.2	0.0	-0.4
Forced vital capacity (FVC)	0.1	0.2	0.6	-0.5	-0.2	-0.3	-0.0	-0.5	-0.1	-0.8	-0.6	-0.7	-0.6	0.5	0.0	-0.5
Weight	0.1	0.4	2.2	-0.6	-1.5	-0.4	-0.9	-0.7	0.8	-0.4	-0.2	0.4	-0.4	-0.2	0.0	-0.5
Trunk fat-free mass	0.1	0.8	4.2	0.5	0.4	0.7	0.7	0.5	2.1	0.3	0.8	0.2	0.6	1.3	0.9	0.6
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.1	-0.0	0.4	-0.4	0.1	0.1	0.4	0.5	-0.0	0.2	-0.5	0.2	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.5	0.7	-0.1	0.2	-0.0	0.4	0.5	0.6	-0.3	-0.0	-0.2	-0.6	-0.1
Gout (self-reported)	0.1	0.1	0.4	0.1	-0.4	-0.0	-0.4	0.3	0.5	-0.1	0.5	0.1	-0.4	-0.6	-0.3	0.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	1.0	0.1	0.5	0.3	-0.4	0.7	0.6	-0.4	-0.0	0.2	0.0	-1.0	-0.2	0.2
High blood pressure (siblings)	0.1	0.2	1.4	-0.3	-0.3	-0.4	-0.3	-1.2	-0.2	0.4	0.0	-0.2	-0.4	0.3	0.1	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.3	0.9	-0.0	0.8	0.4	0.4	0.5	0.6	-0.8	-0.1	-1.0	-0.1	0.3	0.5	0.4
Arm fat-free mass (right)	0.1	0.4	2.0	-0.3	-1.2	-0.2	-0.6	-0.4	1.4	-0.1	0.5	0.4	-0.2	0.4	0.3	-0.1
Heart disease (mother)	0.1	0.2	0.5	0.5	0.4	0.4	0.3	0.6	0.3	0.1	0.5	-0.7	-0.0	-0.2	0.6	0.4
Arm predicted mass (right)	0.1	0.4	2.5	-0.3	-1.0	-0.2	-0.6	-0.3	1.6	-0.2	0.4	0.3	-0.1	0.5	0.4	-0.1
Alcohol intake frequency.	0.1	0.3	0.8	0.7	0.6	0.4	0.1	0.9	0.9	0.4	0.6	0.3	0.5	-0.6	-0.1	0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.7	0.2	-0.2	0.3	0.3	0.7	0.5	-0.5	0.2	-0.8	0.1	0.1	0.2	0.4
Hypertension (Self-reported)	0.1	0.3	0.7	-0.3	-0.6	-0.4	-0.9	-0.8	-0.8	0.4	-0.1	-0.8	-0.4	0.7	-0.0	0.1
Whole body fat-free mass	0.1	0.5	3.3	0.2	-0.2	0.4	0.4	0.3	1.8	0.2	0.7	0.3	0.4	1.0	0.8	0.4
Leg fat-free mass (right)	0.1	0.4	2.7	0.2	-0.3	0.5	0.4	0.5	1.6	0.2	0.6	0.3	0.5	0.6	0.9	0.4
Whole body water mass	0.1	0.5	3.2	0.2	-0.3	0.4	0.3	0.3	1.8	0.1	0.6	0.3	0.4	1.0	0.8	0.4
Leg predicted mass (right)	0.1	0.4	2.4	0.2	-0.3	0.5	0.4	0.4	1.6	0.2	0.6	0.3	0.5	0.6	0.9	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.5	-0.1	0.3	-0.1	0.3	-0.2	0.5	-0.2	0.2	0.7	-0.3	-0.7	-0.6	-0.2
High cholesterol (Self-reported)	0.1	0.1	0.3	0.3	0.5	0.0	-0.3	-0.0	0.2	0.2	0.6	0.5	-0.2	-0.3	0.0	0.4
Basal metabolic rate	0.1	0.3	2.4	-0.1	-0.7	0.1	-0.1	-0.0	1.6	-0.1	0.4	0.3	0.1	0.7	0.5	0.1
Arm fat-free mass (left)	0.1	0.4	1.6	-0.5	-1.3	-0.4	-0.8	-0.7	1.1	-0.2	0.1	0.2	-0.3	0.7	0.1	-0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.6	-0.3	0.3	0.2	0.0	-0.5	0.3	-0.5	-0.4	0.1	-0.1	0.8	-0.1	0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.6	-0.0	0.4	0.1	0.7	0.3	0.6	-0.8	-0.4	0.7	0.1	-0.8	-0.6	-0.6
Arm predicted mass (left)	0.1	0.4	1.7	-0.3	-1.2	-0.2	-0.7	-0.6	1.3	0.1	0.3	0.4	0.0	0.8	0.5	-0.1
Tanning	0.0	0.4	2.2	-0.2	0.2	0.1	0.3	0.7	0.8	-0.1	0.5	-1.2	-0.1	-1.5	-0.4	-0.2
Sitting height	0.0	0.1	0.7	-0.0	0.4	-0.1	0.5	0.1	0.7	-0.2	-0.1	-0.8	0.0	0.5	0.2	0.0
Pulse rate, automated reading	0.0	0.2	0.8	-0.2	-0.0	0.1	-0.2	-0.3	-0.0	-0.7	-0.9	0.3	-0.2	-0.2	-0.5	-0.5

Hub : Genes

TMEM185B

Models

Trait associations