Hub : Genes

PTPN4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.1510	0.0650	0.00170	0.087	NA	0.041	NA	0.044	0.0015	NA	2.3e-02	NA	2.0e-02
2	GTEx	Cells Transformed fibroblasts	0.0610	0.0230	0.00015	0.016	NA	0.024	NA	0.033	0.0230	NA	6.5e-03	NA	1.5e-03
3	GTEx	Skin Sun Exposed Lower leg	0.0610	0.0340	0.00810	0.013	NA	0.013	NA	0.014	0.0280	NA	2.9e-02	NA	2.4e-02
4	YFS	Blood	0.0203	0.0089	0.00016	0.010	0.012	0.014	0.012	0.017	0.0003	6.1e-05	1.1e-05	7.7e-05	1.8e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	2.3	-0.1	-0.7	0.6	1.5
Bipolar Disorder or Schizophrenia	0.5	1.1	1.9	0.5	-1.4	1.0	1.1
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	0.1	0.5	0.9	0.6
Depression (Nagel 2018)	0.1	0.1	0.3	0.4	0.6	0.2	0.2
Intelligence (Savage-Jansen 2018)	0.8	2.6	7.1	0.3	-1.4	1.1	2.7
Neuroticism (Nagel 2018)	0.3	0.6	1.4	0.6	0.6	0.7	1.2
Schizophrenia (2018)	0.3	0.7	1.5	0.7	-1.2	0.8	0.3
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.2	-0.4	-0.1	-0.2
Worry (Nagel 2018)	0.3	0.7	1.4	1.0	0.6	0.3	1.2
Alzheimer’s Disease (in mother)	0.4	0.4	1.5	-0.2	-0.2	-1.2	0.5
Alzheimer’s Disease (in father)	1.2	1.4	2.3	-1.5	1.0	1.5	-0.1
Alzheimer’s Disease (including proxy)	0.6	0.9	1.9	-1.4	1.0	0.6	-0.5
Crohns Disease (2017)	0.2	0.4	0.9	-0.3	0.7	-0.9	-0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	-0.6	0.3	-0.2	0.3
Ulcerative Colitis (UC)	0.2	0.3	0.5	-0.7	-0.3	0.5	0.6
Major Depression (MDD)	2.4	3.0	4.4	-1.8	2.1	0.6	-1.9
Reaction Time	0.6	1.1	3.1	-0.2	0.9	0.8	-1.8
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.3	-0.0	-0.4	0.2	1.5
Breast Cancer	2.0	4.7	11.9	1.9	-1.8	-0.4	3.5
Ovarian Cancer	1.0	1.3	2.1	-1.4	0.6	1.0	-1.5
Prostate Cancer	2.9	4.1	9.1	-1.9	1.4	3.0	-1.3
Age at First Birth	1.0	1.4	3.3	-1.8	0.8	1.1	-0.7
Bipolar Disorder (2011)	0.3	0.3	0.7	0.9	0.1	-0.3	0.4
Body Mass Index (BMI) (2010)	0.9	1.3	2.1	0.6	-0.9	-1.4	1.4
Coronary Artery Disease (CAD)	0.2	0.2	0.6	0.3	-0.2	-0.8	0.4
Crohns Disease (2012)	0.3	0.5	1.0	0.2	1.0	-0.9	-0.2
Mean Putamen Volume	1.1	1.2	2.4	-1.1	1.5	1.0	-0.6
Fasting Glucose	0.7	0.8	2.0	1.4	-0.9	0.2	0.7
HbA1C	0.5	0.6	2.0	0.0	-0.3	-1.4	0.5
HDL Cholesterol	0.2	0.3	0.7	0.5	-0.8	-0.4	0.3
LDL Cholesterol	0.8	1.2	2.9	-0.9	1.7	0.6	-0.9
Lupus	2.4	3.6	5.8	1.5	-2.2	-2.4	1.2
Neuroticism (2016)	0.6	0.8	1.4	-0.6	1.2	-0.5	-1.1
Primary Biliary Cirrhosis	0.5	0.8	1.4	0.9	-1.2	0.1	0.9
Rheumatoid Arthritis	0.3	0.4	1.1	0.4	-0.6	0.3	1.1
Schizophrenia (2014)	0.1	0.3	0.9	-0.2	-0.2	0.9	-0.4
Triglycerides	0.4	0.6	1.1	-0.6	1.0	0.0	-1.0
Type 2 Diabetes (T2D) (2012)	1.5	1.8	3.2	-0.9	1.8	0.2	-1.7
Ulcerative Colitis	0.4	0.6	1.4	-0.8	0.5	1.2	-0.3
Blood Eosinophil Count	0.1	1.1	3.2	-0.5	0.6	1.8	-0.8
Blood Platelet Count	9.9	115.2	243.4	-9.4	10.4	4.6	-15.6
Blood Red Count	0.1	0.5	1.1	1.0	-0.9	0.2	-0.4
Blood White Count	0.2	1.4	3.2	0.7	-1.1	1.8	0.6
Heel T-Score	0.2	1.6	3.6	1.2	-1.9	-0.7	0.9
BMI	0.5	2.8	4.5	1.0	-1.9	-1.5	2.1
Height	1.1	20.7	28.4	-4.9	5.3	2.5	-5.0
Waist Hip Ratio (WHR)	0.3	1.5	3.3	-1.0	1.3	1.8	-0.2
Systolic Blood Pressure	1.6	7.9	11.9	-2.3	3.5	2.6	-2.8
Smoking Status	2.9	7.0	8.6	2.9	-2.8	-1.9	2.8
Allergy or Eczema	0.3	0.9	2.9	-0.7	0.5	1.7	-0.1
Cardiovascular Disease	0.2	0.5	1.1	0.8	0.5	-1.1	0.2
Hypothyroidism (self reported)	0.2	0.5	1.0	-0.2	0.4	1.0	-0.9
Respiratory disease	0.8	1.8	2.6	1.5	-1.4	-0.6	1.6
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.5	-1.0	1.4	0.9	-1.6
Lung FEV1/FVC ratio	5.2	26.3	34.6	-5.6	5.9	3.2	-5.3
Lung FVC	1.1	5.8	9.3	2.9	-3.0	-0.7	2.3
Neuroticism	0.4	0.8	1.9	0.7	0.1	1.4	1.0
Chronotype (morning person)	0.2	0.4	0.9	0.2	-0.7	-1.0	0.5
Hair Pigment	0.0	0.7	1.5	1.2	-0.7	-0.4	0.9
Tanning	0.0	0.4	0.8	-0.5	-0.5	0.9	-0.5
Hand grip strength (left)	0.2	0.5	1.1	0.1	0.2	0.8	-1.0
Number of treatments/medications taken	0.1	0.2	0.5	-0.6	0.1	0.7	0.2
Average weekly spirits intake	0.6	0.7	1.1	-1.1	1.0	-0.0	-0.9
Sensitivity / hurt feelings	0.2	0.4	1.2	0.1	0.6	1.1	0.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.4	0.3	0.6	1.2	0.6
Hearing difficulty/problems: Yes	0.3	0.5	0.6	-0.6	0.7	0.8	-0.6
Relative age of first facial hair	1.0	2.0	5.6	-0.8	1.0	2.4	-0.9
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	4.0	-2.0	1.6	1.6	-0.9
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	0.2	0.1	-0.0	0.4
Ever had hysterectomy (womb removed)	0.8	0.9	2.6	0.3	-0.8	0.7	1.6
Systolic blood pressure, automated reading	2.4	6.9	9.6	-2.3	2.5	3.1	-2.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.6	-0.7	1.1	-0.2	-1.3
Angina	0.5	0.7	1.9	-0.5	0.7	-0.2	-1.4
Medication for hormone replacement therapy	0.6	0.7	1.6	-0.2	1.2	0.0	-1.0
Vitamin and mineral supplements	1.9	2.6	5.4	2.3	-1.5	-0.5	1.5
Supplements: Zinc	2.7	3.0	6.2	2.0	-1.1	-2.5	0.5
Medication: Co-codamol	0.6	0.7	1.5	0.2	-1.2	0.2	1.1
Medication: Metformin	1.0	1.4	2.4	-0.9	1.5	-0.7	-1.5
Diabetes (father)	0.3	0.4	1.4	-0.4	0.3	1.2	-0.2
Diabetes (mother)	0.4	0.6	0.9	0.1	0.9	-0.9	-0.8
Severe depression (siblings)	0.2	0.2	0.9	0.2	0.9	-0.2	-0.2
Pack years adult smoking proportion	0.4	0.7	1.1	0.2	-0.8	1.1	0.9
Impedance of leg (right)	0.1	0.4	1.3	1.2	0.5	-0.2	-0.1
Leg fat-free mass (left)	0.2	1.0	2.9	-1.7	0.6	-0.1	-0.7
Trunk fat percentage	0.1	0.6	1.4	-0.2	-0.7	-1.2	0.7
Hand grip strength (right)	0.2	0.5	1.1	-0.3	0.7	0.7	-1.0
Townsend deprivation index at recruitment	2.6	3.6	5.0	1.8	-2.2	-1.9	1.6
Current tobacco smoking	1.2	2.0	2.8	1.7	-1.5	-0.5	1.6
Average weekly fortified wine intake	2.0	2.3	4.5	-2.1	1.5	0.8	-1.3
Maternal smoking around birth	2.2	3.2	4.8	1.8	-1.9	-2.2	1.2
Fed-up feelings	0.2	0.4	1.3	0.1	-0.2	1.1	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	0.2	0.3	0.7	0.4
Relative age voice broke	1.1	1.7	5.5	-0.5	0.6	2.3	-0.9
Taking other prescription medications	1.5	2.3	5.1	-1.7	0.8	2.3	-0.8
Age when periods started (menarche)	2.8	6.8	12.9	-2.1	2.2	3.6	-2.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.0	0.0	-0.6	1.0	0.4
Heel bone mineral density (BMD) T-score, automated (left)	3.6	8.1	11.6	2.9	-3.4	-1.3	3.3
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.3	0.3	-0.5	-1.2	1.5
Qualifications: CSEs or equivalent	1.1	1.4	3.1	-0.8	1.4	-0.0	-1.8
Serious illness, injury or assault to yourself	0.7	0.8	1.9	-1.4	1.0	0.3	-0.5
High blood pressure	0.3	1.0	1.5	-1.2	0.9	1.1	-0.6
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.0	-0.2	0.3	1.7	-0.3
Multivitamins +/- minerals	1.1	1.3	3.1	-1.8	1.1	0.7	-0.8
Stomach or abdominal pain in last month	0.9	1.1	1.8	1.0	-1.3	-0.4	1.1
Supplements: Glucosamine	0.2	0.3	0.6	-0.8	0.2	-0.7	0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	0.4	-0.6	0.3	-0.2
Medication: Atenolol	0.9	1.1	2.3	-0.9	0.4	-1.5	-1.0
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.7	-0.3	-0.2	0.2
Sitting height	0.0	0.1	0.2	0.4	0.3	-0.4	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	0.2	0.0	0.3	0.3
High blood pressure (mother)	0.8	1.2	3.4	1.1	0.1	-1.8	-0.4
Body mass index (BMI)	0.5	2.2	3.4	0.4	-1.8	-1.4	1.9
Impedance of leg (left)	0.1	0.6	1.0	0.8	1.0	0.3	-0.8
Leg predicted mass (left)	0.2	1.0	2.9	-1.7	0.6	0.0	-0.8
Trunk fat mass	0.1	0.3	0.7	-0.5	-0.4	-0.9	0.3
Waist circumference	0.1	0.3	0.7	-0.8	-0.1	-0.5	0.4
Number of incorrect matches in round	0.4	0.6	1.3	0.2	-1.1	-0.4	0.9
Past tobacco smoking	2.3	4.2	6.6	-1.8	2.4	1.3	-2.6
Alcohol usually taken with meals	0.4	0.7	1.8	-1.0	0.1	1.3	0.1
Nervous feelings	0.6	1.1	3.3	0.6	0.0	0.9	1.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	4.2	1.4	-0.9	-0.4	2.0
Hearing difficulty/problems with background noise	0.2	0.3	0.9	0.2	-0.1	0.9	-0.5
Hair/balding pattern: Pattern 2	1.1	1.4	4.2	2.0	-0.6	-0.8	0.5
Had menopause	0.2	0.3	0.6	-0.1	-0.7	0.8	-0.2
Had other major operations	0.7	0.9	1.6	0.6	-1.3	0.1	1.2
Forced vital capacity (FVC)	0.1	0.3	0.5	0.7	-0.6	0.2	0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.2	5.6	2.2	-2.4	-1.3	2.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.8	0.4	-1.3	-0.7	0.5
Qualifications: None of the above	0.3	0.5	1.9	-0.3	-0.1	-0.4	-1.4
Financial difficulties in last 2 years	0.6	0.8	1.7	0.6	-1.3	-0.3	1.0
Mouth/teeth dental problems	0.1	0.1	0.2	0.3	-0.4	0.3	0.3
Heart attack	0.3	0.3	1.0	-0.4	-0.1	-1.0	-0.2
Allergy	0.3	0.7	2.3	0.5	-0.4	-1.5	-0.2
Pain all over the body in last month	1.0	1.0	2.6	-1.1	1.6	-0.3	-0.4
Diabetes (self-reported)	1.4	2.1	4.5	-1.1	1.6	0.4	-2.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	0.9	-0.3	0.3	0.7
Medication: Ramipril	1.7	2.2	4.7	-2.2	1.1	-0.7	-1.6
Medication: Simvastatin	1.8	2.7	3.9	-1.6	1.7	1.2	-2.0
Fluid intelligence score	0.2	0.4	1.1	0.1	-0.5	0.4	1.0
Illnesses of siblings	0.2	0.2	0.5	-0.1	-0.1	-0.7	-0.6
Neuroticism score	0.3	0.7	1.9	0.1	0.6	1.4	0.7
Weight	0.1	0.4	1.0	-1.0	-0.1	-0.6	0.1
Impedance of arm (right)	0.5	2.4	4.5	-1.0	2.1	-0.9	-1.9
Arm fat percentage (right)	0.3	1.4	3.2	-0.2	-1.0	-1.8	1.1
Trunk fat-free mass	0.2	1.2	2.8	-1.7	0.9	0.4	-1.0
Hip circumference	0.3	1.1	2.5	0.1	-1.1	-1.6	0.8
Time employed in main current job	0.3	0.4	0.6	-0.8	-0.5	0.8	0.3
Alcohol intake versus 10 years previously	0.5	0.7	1.2	-1.1	0.5	-0.3	-1.1
Father’s age at death	0.2	0.3	0.7	-0.8	0.5	0.3	-0.5
Worrier / anxious feelings	0.3	0.6	1.3	-0.3	1.1	0.9	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.8	0.7	-0.5	-1.3	1.0
Falls in the last year	3.3	4.5	7.2	1.4	-2.2	-1.9	2.7
Hair/balding pattern: Pattern 3	2.2	3.4	10.8	-1.5	0.1	3.3	-0.4
Number of live births	0.3	0.5	1.2	0.1	-0.8	-0.2	1.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	1.5	-1.2	1.2	1.1	-1.2
Pulse rate	0.5	0.9	3.4	0.3	-0.3	-1.8	0.2
Happiness	0.2	0.2	0.5	-0.0	-0.1	0.7	-0.6
Noisy workplace	1.5	1.8	2.8	1.7	-1.1	-1.5	1.0
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.3	0.8	-1.1	-0.5	2.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.9	-0.6	1.4	0.1	-1.2
Mouth/teeth dental problems: Dentures	0.5	0.8	1.7	0.4	-0.9	-1.3	0.8
Asthma	1.0	2.0	4.4	1.2	-1.5	-0.2	2.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.0	0.7	-0.0	-1.4	0.4
Medication: Cholesterol lowering	1.2	1.8	2.0	-1.4	1.4	1.2	-1.3
Depression (self-reported)	0.8	1.0	2.9	-0.5	0.7	1.7	-0.4
Medication: Lansoprazole	1.5	1.8	2.2	1.4	-1.4	-0.8	1.5
Prospective memory result	0.3	0.4	0.8	0.3	-0.7	0.3	0.9
Lung cancer (father)	0.1	0.1	0.5	-0.7	0.2	0.1	-0.1
Illnesses of mother	2.1	2.6	9.5	-0.5	-0.1	3.1	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	5.2	-2.2	2.0	1.4	-2.3
Pulse wave Arterial Stiffness index	1.3	1.5	2.1	1.3	-1.3	-1.4	0.7
Impedance of arm (left)	0.5	2.2	4.0	-0.8	2.0	-0.4	-2.0
Arm fat mass (right)	0.1	0.6	1.4	-0.6	-0.5	-1.2	0.6
Trunk predicted mass	0.2	1.4	3.1	-1.8	1.0	0.5	-1.1
Standing height	0.8	8.3	12.2	-2.8	3.5	1.4	-3.3
Length of working week for main job	0.1	0.1	0.3	0.6	-0.3	0.3	-0.3
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.2	-0.2	0.6	-0.1
Breastfed as a baby	0.5	0.7	1.2	-0.7	-0.1	1.1	-1.0
Tense / ‘highly strung’	0.9	1.5	3.3	-1.0	1.8	1.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.6	1.3	-0.8	0.1	0.7
Hair/balding pattern: Pattern 4	1.1	2.7	4.2	-1.5	1.9	-1.0	-2.1
Birth weight of first child	1.8	3.2	5.0	-1.9	2.0	0.5	-2.2
Peak expiratory flow (PEF)	0.2	0.5	0.8	0.6	-0.7	-0.7	0.9
Pulse wave reflection index	0.2	0.3	0.4	0.6	-0.5	-0.6	-0.3
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.0	-1.0	0.6	0.1	-0.6
Loud music exposure frequency	0.1	0.1	0.4	-0.1	0.3	0.0	-0.6
Qualifications: O levels/GCSEs or equivalent	4.6	7.3	10.8	2.9	-2.9	-1.1	3.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.2	-0.3	0.5	0.5	-0.5
Blood clot in the leg (DVT)	0.3	0.4	0.8	0.0	0.6	-0.9	-0.7
Medication: Paracetamol	0.8	1.3	2.2	-1.2	1.5	1.0	-0.5
Headache pain in last month	0.2	0.3	0.8	0.6	0.4	-0.9	0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.4	1.2	-0.8	-0.8	0.7
Glaucoma (self-reported)	1.6	1.9	3.6	-1.3	1.2	-0.8	-1.9
Gout (self-reported)	0.0	0.0	0.1	-0.0	-0.3	0.0	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	-0.5	0.3	0.9	-0.8
Medication: Amlodipine	1.8	2.5	3.6	1.4	-1.9	-1.1	1.7
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.5	0.0	-0.5	1.2	1.2
Birth weight	0.2	0.4	0.9	-0.3	0.5	0.9	-0.6
Chronic bronchitis/emphysema (mother)	1.5	1.7	3.5	1.1	-1.3	-1.9	0.8
High blood pressure (siblings)	0.7	1.1	2.6	0.1	-0.3	1.6	1.2
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	-0.2	0.1	0.4	-0.5
Body fat percentage	0.2	1.0	1.7	0.1	-1.1	-1.3	1.0
Leg fat percentage (right)	0.5	1.8	3.3	0.6	-1.5	-1.0	1.8
Arm fat-free mass (right)	0.1	0.8	1.8	-1.4	0.4	0.9	-0.5
Exposure to tobacco smoke outside home	2.8	3.7	5.8	2.4	-2.4	-0.4	1.8
Comparative body size at age 10	1.3	3.7	7.0	1.8	-2.6	-0.9	2.0
Number of full brothers	0.6	0.8	2.0	1.4	-0.9	-0.4	-0.3
Worry too long after embarrassment	0.4	0.7	2.2	0.6	-0.4	0.1	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.4	-0.0	0.7	-0.1
Wheeze or whistling in the chest in last year	1.7	3.1	6.1	1.0	-1.3	-2.5	1.8
Number of children fathered	0.3	0.3	0.7	-0.3	-0.5	0.8	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	-0.2	0.4	0.6	-0.5
Age at first live birth	3.9	7.0	10.8	-2.5	2.5	3.3	-2.2
Pulse wave peak to peak time	1.7	2.0	2.9	-1.4	1.4	1.7	-0.9
Health satisfaction	0.5	0.7	1.7	0.0	-1.3	-0.1	1.0
Shortness of breath walking on level ground	1.0	1.1	3.1	0.6	-1.1	-0.0	1.8
Qualifications: College or University degree	0.6	2.0	4.9	1.0	-0.8	-1.1	2.2
Eye problems/disorders: None of the above	0.5	0.6	1.1	-1.0	0.5	1.0	0.1
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.8	1.7	-1.1	-1.1	-0.0
Emphysema/chronic bronchitis	0.6	0.7	1.4	0.1	-1.1	-0.1	1.2
Medication for pain relief, constipation, heartburn	0.2	0.4	1.1	0.6	-1.0	0.0	0.4
Neck or shoulder pain in last month	0.5	0.8	2.9	-0.0	-0.4	1.7	-0.1
Medication: Blood pressure	0.7	1.2	2.4	-1.6	0.8	0.9	-0.8
Angina (self-reported)	0.7	0.9	2.3	-0.6	1.0	-0.2	-1.5
Migraine (self-reported)	0.5	0.6	1.4	-0.1	-0.5	-0.8	1.2
Medication: Ibuprofen	0.4	0.4	1.2	0.6	0.2	-1.1	0.3
Medication: Allopurinol	0.1	0.1	0.5	0.0	-0.7	-0.1	0.3
Medication: Omeprazole	0.7	0.8	2.4	-0.2	-0.7	-0.5	1.5
Medication: Seretide 50 evohaler	4.8	5.6	9.1	2.5	-2.6	-0.4	3.0
Mean time to correctly identify matches	1.6	3.1	5.0	-1.1	1.4	2.2	-2.1
Heart disease (mother)	0.7	0.9	2.9	-0.1	0.3	-1.7	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.5	-0.5	1.2	0.4	-0.4
Whole body fat mass	0.1	0.4	0.9	-0.5	-0.5	-0.9	0.5
Leg fat mass (right)	0.2	0.7	1.1	-0.1	-1.0	-0.7	1.1
Arm predicted mass (right)	0.2	0.9	1.9	-1.4	0.6	1.1	-0.5
Pulse rate, automated reading	0.2	0.6	2.3	-0.1	-0.2	-1.5	0.4
Alcohol intake frequency.	0.1	0.2	0.8	0.1	0.0	-0.4	-0.9
Comparative height size at age 10	0.7	4.1	6.7	-2.6	2.1	1.1	-2.0
Number of full sisters	0.9	1.1	4.4	-0.2	-0.1	2.1	0.0
Suffer from ‘nerves’	1.1	1.8	3.6	-1.1	1.4	1.9	0.5
Overall health rating	0.3	0.6	1.3	0.5	-1.1	-0.4	0.7
Chest pain or discomfort	1.7	2.4	5.2	1.2	-1.0	-2.3	1.5
Had major operations	0.2	0.2	0.5	-0.2	-0.2	0.5	0.7
Age at last live birth	1.6	2.3	4.5	-1.3	0.9	2.1	-1.5
Family relationship satisfaction	0.8	1.0	2.1	1.0	-0.7	1.4	0.7
Leg pain on walking	0.0	0.1	0.2	0.1	-0.2	-0.1	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	3.8	-1.4	2.0	0.8	-1.5
Commuting to job workplace: Car/motor vehicle	0.5	0.5	0.9	-1.0	0.3	0.6	-0.9
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.2	-0.3	-0.5	0.1
Medication: Aspirin	1.6	2.1	3.0	-1.4	1.7	-0.5	-1.7
Supplements: Vitamin C	0.1	0.2	0.4	0.6	-0.4	0.3	-0.2
Knee pain experienced in last month	0.2	0.3	0.8	0.3	-0.2	-0.9	0.4
Hypertension (Self-reported)	0.1	0.2	0.4	-0.6	0.2	0.5	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.4	4.0	5.6	2.1	-2.4	-0.7	2.3
Illnesses of father: Heart disease	1.0	1.3	1.8	1.0	-1.3	-0.9	1.3
Illnesses of siblings: Diabetes	0.2	0.2	0.5	-0.0	0.7	-0.6	-0.1
Smoking status: Previous	1.0	1.5	1.9	0.8	-1.4	-1.3	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	-0.4	0.3	-0.3	-0.8
Whole body fat-free mass	0.2	1.3	3.3	-1.8	0.8	0.4	-1.0
Leg fat-free mass (right)	0.3	1.5	3.8	-1.9	0.9	0.3	-1.1
Arm fat percentage (left)	0.3	1.1	2.0	-0.1	-1.1	-1.4	1.1
Average weekly red wine intake	0.1	0.2	0.6	0.0	-0.1	0.8	0.4
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.0	1.4	-0.5	-0.5	1.2
Mood swings	0.5	0.8	2.5	0.1	0.5	1.6	0.7
Loneliness, isolation	0.9	1.2	4.4	0.7	0.0	2.1	-0.2
Long-standing illness, disability or infirmity	0.1	0.1	0.4	-0.1	-0.2	-0.6	0.1
Ever had bowel cancer screening	0.7	0.8	0.8	0.9	-0.9	-0.9	0.9
Diabetes diagnosed by doctor	1.5	2.4	3.8	-1.4	2.0	0.4	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.2	0.1	0.4	0.3
Friendships satisfaction	4.6	5.7	10.0	2.3	-2.8	0.5	3.2
Qualifications: nursing, teaching	0.2	0.3	0.7	-0.3	0.5	0.8	0.2
Commuting to job workplace: Walk	0.5	0.6	1.2	1.1	0.7	-0.8	-0.1
Eye problems/disorders: Cataract	1.7	2.0	3.1	-0.8	1.8	1.3	-1.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.4	-0.6	1.2	-0.1	-0.9
Medication for cholesterol	0.1	0.1	0.2	0.4	-0.3	0.2	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.4	0.7	-1.2	-0.2	1.1
Back pain experienced in last month	2.3	3.4	6.5	2.5	-1.6	-1.2	1.7
Mineral and other dietary supplements	0.9	1.2	3.4	1.0	-0.5	1.8	0.5
Breast cancer (self-reported)	0.3	0.3	0.8	-0.3	-0.9	0.5	-0.4
Asthma (self-reported)	1.1	2.2	4.7	1.3	-1.4	-0.5	2.2
Osteoporosis (self-reported)	2.7	3.4	7.0	-1.5	2.1	0.2	-2.6
Osteoarthritis (self-reported)	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.3
Medication: Aspirin	1.5	1.9	3.0	-1.4	1.6	0.0	-1.7
Medication: Gliclazide	1.8	2.1	3.3	-1.4	1.8	-1.0	-1.4
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	-0.2	0.6	-0.1	-1.2
Smoking status: Current	1.1	1.7	2.4	1.5	-1.4	-0.3	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.3	-0.5	0.6	2.1	-1.0
Whole body water mass	0.2	1.3	3.4	-1.8	0.8	0.4	-0.9
Leg predicted mass (right)	0.3	1.5	3.7	-1.9	0.9	0.3	-1.1
Arm fat mass (left)	0.2	0.6	1.2	-0.5	-0.8	-1.1	0.8
Number of self-reported non-cancer illnesses	0.3	0.5	1.2	0.3	-0.8	0.6	1.1
Average weekly champagne plus white wine intake	0.6	0.9	3.2	0.0	0.5	1.8	0.1
Miserableness	0.1	0.2	0.8	0.0	0.9	0.1	0.1
Guilty feelings	3.3	4.9	7.8	2.8	-2.1	-1.6	2.2
Wears glasses or contact lenses	0.4	0.4	1.4	-0.1	0.3	-1.2	-0.5
Ever taken oral contraceptive pill	2.9	3.3	4.5	2.0	-2.1	-1.6	1.3
Hearing aid user	0.1	0.1	0.2	-0.2	-0.1	0.4	-0.4
Mother’s age at death	0.3	0.3	1.1	1.0	-0.0	-0.5	0.0
Financial situation satisfaction	0.6	0.8	1.3	-1.2	0.0	0.7	-1.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	0.7	-0.7	0.2	0.4
Commuting to job workplace: Public transport	1.0	1.2	2.8	-0.6	1.2	-0.3	-1.7
Eye problems/disorders: Glaucoma	1.4	1.6	4.2	-1.1	0.6	-0.9	-2.0
Medication: Blood pressure	0.3	0.5	1.2	0.2	-0.9	-0.0	1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.0	0.8	-0.5	-0.9	1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.5	-0.3	0.1	-1.6	0.3
High cholesterol (Self-reported)	0.0	0.0	0.1	-0.1	0.0	-0.3	0.1
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.4	0.1	0.4	0.6
Medication: Paracetamol	0.3	0.4	0.7	-0.7	0.5	0.8	0.5
Medication: Lisinopril	1.3	1.7	4.3	2.1	-1.2	-1.0	0.1
Medication: Atorvastatin	0.6	0.7	0.9	0.9	-0.8	-0.8	0.8
Illnesses of father: High blood pressure	2.7	3.3	5.6	1.5	-2.3	-0.2	2.4
Alcohol drinker status: Never	0.1	0.1	0.4	-0.0	0.1	-0.6	0.2
Ever smoked	1.7	3.0	5.5	1.4	-2.1	-0.6	2.4
Basal metabolic rate	0.1	0.8	2.3	-1.5	0.5	0.0	-0.6
Leg fat percentage (left)	0.3	1.2	2.2	0.4	-1.4	-0.7	1.5
Arm fat-free mass (left)	0.2	0.8	2.6	-1.6	0.4	0.6	-0.2
Number of operations (self-reported)	1.2	1.8	4.7	0.6	-1.4	-0.0	2.2
Average weekly beer plus cider intake	0.2	0.3	0.6	0.6	-0.8	0.1	0.3
Irritability	0.3	0.4	0.8	-0.5	0.2	0.9	0.8
Risk taking	0.4	0.6	1.9	-0.7	0.0	-1.4	-0.4
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.6	1.3	-0.5	-0.4	0.3
Fractured/broken bones in last 5 years	0.1	0.2	0.3	-0.6	0.1	0.6	0.2
Age started oral contraceptive pill	5.7	7.1	11.1	-3.3	2.5	2.7	-1.9
Diastolic blood pressure, automated reading	0.9	2.7	3.8	-1.9	1.4	1.9	-1.2
Ever depressed for a whole week	0.2	0.2	0.6	-0.7	-0.3	0.5	0.2
Unable to work because of sickness or disability	0.3	0.4	1.1	0.6	-1.0	0.5	-0.3
Commuting to job workplace: Cycle	2.6	3.2	4.1	1.9	-1.7	-1.4	2.0
Myopia	0.1	0.2	0.5	-0.0	-0.7	-0.2	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.5	1.2	-0.8	-0.8	0.7
Cholesterol lowering medication	0.1	0.1	0.2	-0.3	0.3	0.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.4	0.1	-0.6	-0.7	1.2
Pain experienced in last month	0.1	0.2	0.4	-0.6	-0.2	-0.2	-0.4
Supplements: Calcium	1.0	1.0	1.2	-1.0	0.9	-1.1	-1.1
Basal cell carcinoma (self-reported)	2.9	3.5	6.5	1.8	-2.0	0.1	2.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	-0.3	-0.4	-1.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	-0.3	0.8	-0.6	-1.0
Heart disease (siblings)	0.1	0.2	0.3	-0.4	0.3	0.1	-0.6
Alcohol drinker status: Previous	0.5	0.5	1.2	1.1	-0.5	0.1	0.8
Pack years of smoking	0.4	0.5	1.4	0.0	-0.6	1.2	0.7
Impedance of whole body	0.3	1.4	3.1	-0.2	1.8	0.1	-1.6
Leg fat mass (left)	0.1	0.3	0.6	-0.2	-0.7	-0.5	0.7
Arm predicted mass (left)	0.2	1.1	3.2	-1.8	0.7	0.6	-0.4