Best TWAS P=6.61e-22 · Best GWAS P=1.93e-31 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SUSD5 | 0.38 | 0.12 | lasso | 10 | 0.24 | 6.1e-29 | -3.762 | 6.5 | 6.7e-11 | 0.14 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Adipose Visceral Omentum | RP11-10C24.2 | 0.27 | 0.04 | lasso | 14 | 0.15 | 2.2e-08 | -0.019 | 6.7 | 2.2e-11 | 0.58 | 0.11 | 0.88 | TRUE |
| 3 | GTEx | Artery Tibial | RP11-10C24.2 | 0.11 | 0.06 | lasso | 3 | 0.05 | 8.9e-05 | 11.559 | 9.6 | 6.6e-22 | 0.87 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | SUSD5 | 0.20 | 0.26 | lasso | 1 | 0.25 | 5.5e-19 | 7.567 | 7.6 | 3.8e-14 | 0.20 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Muscle Skeletal | CRTAP | 0.17 | 0.00 | enet | 16 | 0.01 | 1.3e-02 | 0.183 | -5.7 | 1.6e-08 | -0.03 | 0.18 | 0.03 | TRUE |
| 6 | GTEx | Skin Sun Exposed Lower leg | PDCD6IP | 0.14 | 0.04 | enet | 29 | 0.05 | 2.6e-05 | -0.019 | -5.7 | 1.2e-08 | -0.51 | 0.19 | 0.80 | TRUE |
| 7 | GTEx | Testis | CRTAP | 0.16 | 0.04 | lasso | 4 | 0.11 | 1.7e-05 | -3.080 | -5.4 | 7.3e-08 | -0.02 | 0.56 | 0.03 | FALSE |
| 8 | GTEx | Thyroid | GLB1 | 0.30 | 0.20 | enet | 16 | 0.21 | 5.1e-16 | -6.368 | -5.7 | 1.6e-08 | 0.07 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Thyroid | CRTAP | 0.23 | 0.10 | enet | 26 | 0.16 | 1.9e-12 | -6.368 | -7.8 | 9.1e-15 | 0.10 | 0.99 | 0.00 | TRUE |
| 10 | GTEx | Thyroid | RP11-627J17.1 | 0.29 | 0.08 | enet | 22 | 0.11 | 5.0e-09 | -6.402 | -9.2 | 3.8e-20 | 0.09 | 0.97 | 0.00 | TRUE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | SUSD5 | 0.27 | 0.11 | lasso | 5 | 0.15 | 2.4e-19 | 7.443 | 8.2 | 1.9e-16 | 0.21 | 1.00 | 0.00 | TRUE |
| 12 | YFS | Blood | GLB1 | 0.05 | 0.01 | enet | 9 | 0.02 | 5.2e-06 | 4.658 | 6.2 | 4.1e-10 | 0.03 | 0.85 | 0.00 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CRTAP | 0.02 | 0.01 | blup | 55 | 0.01 | 1.4e-03 | -6.654 | -6.8 | 7.4e-12 | 0.08 | 0.04 | 0.41 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GLB1 | 0.05 | 0.03 | blup | 83 | 0.03 | 2.3e-04 | -5.577 | 6.0 | 2.2e-09 | 0.00 | 0.32 | 0.02 | TRUE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SUSD5 | 0.05 | 0.00 | blup | 74 | 0.01 | 3.2e-02 | 6.747 | 6.8 | 1.2e-11 | 0.10 | 0.03 | 0.08 | TRUE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GLB1 | 0.03 | 0.00 | blup | 84 | 0.02 | 4.9e-03 | -3.157 | 6.6 | 4.3e-11 | 0.05 | 0.10 | 0.04 | TRUE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | CRTAP | 0.07 | 0.03 | blup | 55 | 0.04 | 4.3e-05 | -7.693 | -6.6 | 3.1e-11 | 0.11 | 0.04 | 0.92 | TRUE |