TWAS hub - SUSD5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3820	0.0520	0.0e+00	0.122	0.201	0.239	0.216	0.240	1.3e-14	5.3e-24	9.5e-29	7.7e-26	6.1e-29
2	GTEx	Cells Transformed fibroblasts	0.2050	0.0630	5.8e-06	0.256	NA	0.206	NA	0.253	3.0e-19	NA	2.0e-15	NA	5.5e-19
3	GTEx	Stomach	0.3720	0.1040	3.0e-03	0.005	NA	-0.002	NA	-0.002	1.7e-01	NA	4.2e-01	NA	4.3e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.2705	0.0492	5.4e-12	0.112	0.116	0.137	0.151	0.154	3.4e-14	1.1e-14	2.8e-17	6.3e-19	2.4e-19
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0543	0.0278	4.5e-03	-0.002	0.009	0.004	NA	-0.001	8.2e-01	3.2e-02	1.2e-01	NA	4.7e-01
6	TCGA	Thyroid Carcinoma	0.1650	0.0440	1.4e-12	0.154	0.148	0.147	NA	0.153	7.6e-15	3.2e-14	3.4e-14	NA	9.7e-15

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6
Forced vital capacity (FVC)	6.1	23.3	41.5	5.9	6.0	6.4	5.1	-1.2
Unable to work because of sickness or disability	4.7	6.1	12.3	-2.0	-3.5	-3.4	-2.8	0.8
Myopia	4.4	6.3	12.3	3.5	2.7	3.4	2.6	-0.2
Number of full sisters	4.2	5.1	8.2	-2.6	-2.8	-2.6	-2.9	-0.9
Lung FVC	4.1	20.8	43.0	4.7	6.2	6.6	4.7	-0.1
Forced vital capacity (FVC), Best measure	4.0	14.8	25.4	5.0	4.5	5.0	4.1	-1.0
Forced expiratory volume in 1-second (FEV1)	3.8	13.0	24.6	4.4	4.5	5.0	3.6	-0.7
Medication: Atenolol	3.3	4.2	8.6	2.1	2.3	2.5	2.9	0.5
Diabetes (father)	3.2	3.9	8.0	2.3	2.8	2.8	1.4	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.9	9.3	17.1	4.1	3.5	4.1	2.9	-1.0
Medication: Aspirin	2.7	3.5	7.6	1.5	2.8	2.2	1.6	1.9
Mouth/teeth dental problems: Mouth ulcers	2.5	4.0	6.8	2.1	2.6	2.3	1.9	-2.1
Birth weight of first child	2.3	4.1	6.2	2.3	2.5	2.5	2.0	1.9
Friendships satisfaction	2.3	2.8	5.7	1.9	1.7	2.4	1.1	1.9
Fasting Glucose	2.2	2.6	6.2	-0.7	-2.2	-2.5	-1.8	-1.1
Waist Hip Ratio (WHR)	2.2	10.0	14.3	3.4	3.7	3.1	3.8	3.3
Happiness	2.2	2.7	11.7	0.4	1.2	1.4	0.9	3.4
Coronary Artery Disease (CAD)	2.0	2.4	4.6	1.8	0.9	1.7	1.7	2.1
Supplements: Zinc	2.0	2.2	8.7	0.4	2.9	1.7	0.5	1.1
Medication for pain relief, constipation, heartburn	2.0	3.4	9.8	-1.0	-3.1	-2.2	-1.8	-1.2
Comparative height size at age 10	2.0	10.9	20.4	4.2	3.4	4.5	3.9	-0.4
Medication: Aspirin	2.0	2.7	6.2	1.1	2.5	1.9	1.6	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.2	8.9	2.9	2.2	3.0	1.7	0.2
Alzheimer’s Disease (in mother)	1.9	2.2	10.2	-0.5	1.5	0.6	-0.1	3.2
Illnesses of father: Heart disease	1.9	2.6	6.7	1.7	2.6	1.6	1.4	1.2
Handedness (chirality/laterality): Left-handed	1.9	2.2	3.2	-1.0	-1.8	-1.8	-1.7	-1.8
Height	1.8	35.6	67.7	6.5	7.6	8.2	6.8	-0.2
Number of incorrect matches in round	1.7	2.8	5.8	1.3	2.2	2.4	2.1	-0.3
Schizophrenia vs Biploar Disorder	1.6	2.1	3.6	-1.7	-1.9	-1.3	-1.7	-1.1
Lupus	1.6	2.4	5.7	-1.4	-2.0	-1.7	-2.4	-0.0
Hearing difficulty/problems with background noise	1.6	2.5	5.5	-0.9	-2.1	-2.1	-2.3	-0.0
Migraine (self-reported)	1.6	2.0	5.4	0.7	2.3	2.3	0.7	0.6
Commuting to job workplace: Cycle	1.6	1.9	5.1	0.7	1.4	1.6	2.3	1.2
Body Mass Index (BMI) (2010)	1.5	2.0	3.6	-1.1	-1.5	-1.9	-1.8	-1.4
Impedance of arm (right)	1.5	6.9	12.0	2.5	3.3	3.5	3.4	-0.7
Exposure to tobacco smoke at home	1.5	1.7	3.1	-1.4	-1.6	-1.7	-1.8	-0.0
Average weekly red wine intake	1.5	2.2	7.0	2.6	0.2	1.1	1.8	-1.3
Supplements: Calcium	1.5	1.7	5.8	0.6	2.4	1.5	1.2	0.4
Smoking Status	1.4	3.3	15.2	-1.4	-0.5	-1.4	-0.2	3.9
Medication: Lisinopril	1.4	1.8	5.1	-2.2	-1.0	-1.8	-1.0	0.6
Risk taking	1.4	2.1	4.6	-2.2	-0.8	-2.0	-0.5	1.7
Relative age voice broke	1.3	2.0	3.2	-1.8	-1.2	-1.6	-1.4	1.7
Impedance of arm (left)	1.3	6.0	11.0	1.9	3.3	3.3	3.3	-0.6
Standing height	1.3	12.4	22.7	4.5	3.6	4.8	4.1	-1.1
Peak expiratory flow (PEF)	1.3	3.0	7.1	2.0	2.1	2.7	1.2	-0.9
Commuting to job workplace: Walk	1.3	1.4	2.8	-0.7	-1.7	-1.3	-1.6	0.9
Mineral and other dietary supplements	1.3	1.7	4.5	-0.8	-2.1	-1.5	-1.7	-0.0
High cholesterol (Self-reported)	1.3	2.3	3.7	-1.7	-1.5	-1.9	-1.8	1.1
Serious illness, injury or assault to yourself	1.2	1.4	3.2	-0.9	-1.6	-1.8	-0.1	1.3
Had other major operations	1.2	1.4	3.0	-0.3	1.7	1.3	1.4	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.8	1.3	1.0	1.5	1.0	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	3.8	-0.0	-2.0	-1.8	-1.3	0.2
Waist circumference	1.1	4.2	7.9	2.8	2.2	2.5	2.4	0.4
Medication: Amlodipine	1.1	1.6	6.5	-1.6	0.4	-0.6	-0.2	2.5
Alzheimer’s Disease (including proxy)	1.0	1.4	5.8	-0.8	1.2	0.2	-0.9	2.4
Past tobacco smoking	1.0	1.8	8.3	-0.2	-0.3	-0.2	-1.5	-2.9
Age at first live birth	1.0	1.8	3.6	1.7	0.9	1.0	1.9	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.7	1.6	1.3	1.4	0.9	-0.3
Number of self-reported non-cancer illnesses	1.0	1.7	5.4	-0.2	1.8	1.2	0.5	2.3
Ever smoked	1.0	1.8	7.9	0.6	0.5	0.3	1.6	2.8
Allergy or Eczema	0.9	2.3	4.0	2.0	1.8	1.6	1.7	1.1
Hearing difficulty/problems: Yes	0.9	1.3	3.5	-0.8	-1.0	-1.3	-1.2	1.9
Leg fat-free mass (left)	0.9	4.6	10.4	2.6	2.5	3.2	1.8	-0.6
Taking other prescription medications	0.9	1.4	4.3	0.7	1.5	0.9	0.8	2.1
Chronic bronchitis/emphysema (father)	0.9	1.1	2.4	-1.5	1.5	0.5	1.2	0.6
Depression (self-reported)	0.9	1.0	2.6	-1.1	-1.2	-1.6	-0.8	-0.5
Neck or shoulder pain in last month	0.9	1.3	4.9	-1.6	0.0	-0.8	-0.2	2.2
Family relationship satisfaction	0.9	1.1	2.7	-0.4	1.2	0.9	1.1	1.6
Smoking status: Previous	0.9	1.3	4.0	0.8	0.7	0.9	1.4	2.0
Ever taken oral contraceptive pill	0.9	1.0	2.8	0.0	-0.9	-1.7	-1.1	-1.1
Primary Biliary Cirrhosis	0.8	1.1	2.7	-1.1	-1.2	-1.1	-1.7	0.4
Ever had hysterectomy (womb removed)	0.8	0.9	1.9	0.2	1.4	1.2	1.0	-1.1
Hayfever, allergic rhinitis or eczema	0.8	1.7	2.5	1.4	1.4	1.1	1.5	1.6
Sitting height	0.8	5.6	11.9	3.0	2.0	3.4	1.3	-2.7
Leg predicted mass (left)	0.8	4.0	9.3	2.5	2.3	3.0	1.7	-0.6
Heart attack	0.8	1.0	2.8	0.2	1.3	1.0	1.7	0.7
Illnesses of siblings	0.8	1.1	2.6	-0.8	-1.6	-1.0	0.4	-1.5
Hair/balding pattern: Pattern 3	0.8	1.2	2.4	1.6	1.5	1.1	0.8	-0.7
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.1	0.6	0.9	1.1	1.0	1.4
Headache pain in last month	0.8	1.4	3.0	-1.7	-0.3	-1.5	-1.4	-1.3
Number of children fathered	0.8	0.9	2.5	-1.0	-0.5	-1.0	-0.6	1.6
Leg fat-free mass (right)	0.8	4.5	10.7	2.5	2.5	3.3	1.9	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	4.3	0.2	-0.9	0.1	0.5	2.1
Leg predicted mass (right)	0.8	4.4	10.7	2.4	2.5	3.3	1.8	-0.4
Medication: Blood pressure	0.8	1.6	3.0	-1.2	-1.7	-1.6	-1.6	-0.2
Intelligence (Savage-Jansen 2018)	0.7	2.2	7.5	0.8	2.7	2.2	0.5	-0.4
Neuroticism (2016)	0.7	1.1	2.0	1.4	0.7	1.1	1.3	1.0
Pack years adult smoking proportion	0.7	1.0	2.0	1.1	1.4	0.8	0.7	-1.4
Length of working week for main job	0.7	0.7	2.5	-1.1	-0.1	-1.6	-0.3	-0.8
Pulse wave reflection index	0.7	0.8	3.3	-0.5	-0.3	0.3	-1.1	-1.8
Medication: Allopurinol	0.7	0.9	2.6	1.6	0.7	1.1	0.5	1.0
Alcohol intake frequency.	0.7	1.7	3.4	-1.1	-1.3	-1.6	-1.8	-1.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.4	-0.1	0.9	0.8	-1.1	-1.5
Ever had bowel cancer screening	0.7	0.8	2.5	0.1	1.4	1.6	-0.6	0.4
Eye problems/disorders: Cataract	0.7	0.8	3.8	-0.8	0.0	-0.3	-1.9	-0.3
Back pain experienced in last month	0.7	1.0	1.9	1.4	1.2	1.1	1.2	0.3
Osteoporosis (self-reported)	0.7	0.9	3.7	0.1	1.1	0.7	1.9	0.3
Smoking status: Current	0.7	1.1	3.5	-1.1	-0.3	-1.4	-0.0	1.9
Average weekly beer plus cider intake	0.7	1.0	4.5	-0.9	0.7	0.2	-0.4	2.1
Ever depressed for a whole week	0.7	0.9	3.2	-0.0	1.8	1.1	0.7	0.7
Basal cell carcinoma (self-reported)	0.7	0.9	2.2	-1.2	-1.5	-1.0	-0.6	0.2
Pack years of smoking	0.7	1.1	2.5	0.9	1.6	0.9	0.9	-1.2
Depressed Affect (Nagel 2018)	0.6	1.2	6.4	-0.7	0.4	0.1	-0.4	2.5
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.9	0.4	1.9	2.0	0.4	0.7
Rheumatoid Arthritis	0.6	0.8	2.3	0.1	1.5	1.2	0.9	0.6
Average weekly spirits intake	0.6	0.7	2.2	1.5	0.3	0.9	1.0	0.4
Medication: Metformin	0.6	0.9	2.0	0.9	0.7	0.8	1.4	1.2
Severe depression (siblings)	0.6	0.7	1.8	1.3	0.8	0.8	0.9	0.2
Current tobacco smoking	0.6	0.9	3.6	-0.9	-0.3	-1.1	-0.0	1.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.4	0.6	1.5	1.0	1.0	0.1
Allergy	0.6	1.5	2.7	-1.7	-1.6	-1.2	-1.0	-1.2
Diabetes (self-reported)	0.6	0.8	1.6	0.8	1.3	1.1	1.1	-0.7
Time employed in main current job	0.6	0.7	1.5	-0.8	-1.1	-0.7	-0.8	-1.2
Father’s age at death	0.6	0.8	1.8	0.4	1.3	1.2	1.0	0.5
Number of live births	0.6	0.8	3.3	-0.4	-0.9	-0.5	-1.8	0.6
Pulse rate	0.6	1.1	5.2	-0.1	-0.1	0.2	-1.0	2.3
Loud music exposure frequency	0.6	0.6	2.9	0.5	0.7	0.2	0.2	1.7
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.2	1.4	1.0	1.5	-0.5	0.7
Birth weight	0.6	1.2	2.9	-1.2	1.4	0.7	-0.8	1.7
Number of full brothers	0.6	0.8	1.4	-0.6	-1.1	-1.1	-0.8	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.8	0.0	0.9	1.0	0.2	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.5	-0.5	-0.3	-1.2	-1.1	-1.2
Loneliness, isolation	0.6	0.9	3.1	-1.1	-0.3	-0.4	-0.9	1.8
Medication for cholesterol	0.6	0.9	2.0	0.8	1.1	1.0	1.4	-0.5
Average weekly champagne plus white wine intake	0.6	0.8	3.4	-1.8	-0.1	-0.9	-0.3	-0.5
Hearing aid user	0.6	0.7	2.1	-0.7	-0.2	-0.1	-1.4	1.2
Medication: Bendroflumethiazide	0.6	1.0	2.7	-1.6	-0.9	-1.2	-0.6	0.8
Alcohol drinker status: Never	0.6	0.7	3.1	-0.9	-0.5	-0.6	-1.8	-0.1
Number of operations (self-reported)	0.6	0.8	3.8	0.5	0.9	0.4	0.4	-1.9
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.5	-0.0	1.2	0.8	1.6	0.6
Worry (Nagel 2018)	0.5	1.0	4.1	-0.6	1.0	0.7	0.0	2.0
Reaction Time	0.5	0.9	3.0	-1.1	-0.8	-1.7	0.2	-0.8
Breast Cancer	0.5	1.3	2.3	-0.5	-1.1	-1.3	-1.5	-1.5
Respiratory disease	0.5	1.0	3.7	0.0	1.2	0.8	-0.6	1.9
Lung FEV1/FVC ratio	0.5	2.3	6.6	-1.4	-2.6	-1.8	-1.1	0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.5	1.2	0.6	1.0	1.0	-0.2
Medication: Co-codamol	0.5	0.6	1.4	-0.6	-1.1	-1.2	-0.6	0.6
Average weekly fortified wine intake	0.5	0.5	1.4	-0.4	-0.9	-1.2	-0.3	0.9
Qualifications: CSEs or equivalent	0.5	0.7	1.5	-0.4	-1.1	-1.0	-1.2	0.5
Multivitamins +/- minerals	0.5	0.6	2.9	-1.7	0.3	-0.6	-0.2	-0.2
Medication: Ramipril	0.5	0.7	2.1	-0.6	-1.0	-0.9	-0.1	1.4
Alcohol intake versus 10 years previously	0.5	0.8	3.7	-0.4	-0.7	-0.2	0.5	1.9
Medication: Cholesterol lowering	0.5	0.8	2.9	-0.1	1.0	0.5	0.7	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.6	-1.3	-0.7	-1.1	-1.1	-0.4
Blood clot in the leg (DVT)	0.5	0.7	2.0	-0.3	1.4	1.1	-0.8	-0.3
High blood pressure (siblings)	0.5	0.7	2.2	-0.3	0.8	0.2	-1.1	1.5
Suffer from ‘nerves’	0.5	0.7	3.5	-0.9	0.2	0.1	-0.3	1.9
Knee pain experienced in last month	0.5	0.8	2.8	-1.3	0.0	-0.4	-1.7	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.2	1.8	1.0	1.2	0.4	0.0
Asthma (self-reported)	0.5	1.0	4.2	0.7	0.9	0.5	-0.3	2.0
Wears glasses or contact lenses	0.5	0.6	1.1	-1.1	-0.9	-1.0	0.7	0.3
Mother’s age at death	0.5	0.6	1.8	-1.1	0.7	0.2	0.5	1.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	0.1	-1.3	-0.9	-0.8	0.5
Eye problems/disorders: Glaucoma	0.5	0.6	1.5	-0.5	-1.1	-0.6	0.0	1.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.4	-0.5	1.2	0.8	-1.1	-0.4
Alcohol drinker status: Previous	0.5	0.6	2.8	0.8	0.2	0.1	-0.2	-1.7
Bipolar Disorder (2018)	0.4	0.6	1.5	0.2	1.2	0.6	0.9	1.0
Depression (Nagel 2018)	0.4	0.7	2.0	0.2	1.0	0.8	0.5	1.4
Triglycerides	0.4	0.7	2.6	0.1	-0.0	-0.2	1.2	1.6
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.3	-1.1	-0.2	-0.9	-0.4	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	-0.1	-1.2	-0.6	-0.6	1.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.5	-0.5	1.2	0.7	0.5	0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	-0.1	0.9	0.3	-0.6	1.0
Trunk fat mass	0.4	1.7	2.7	1.3	1.6	1.6	1.4	-1.1
Alcohol usually taken with meals	0.4	0.6	1.7	-0.1	-0.7	-0.9	0.8	-1.3
Weight	0.4	1.8	3.3	1.8	1.4	1.8	1.2	-0.8
Noisy workplace	0.4	0.5	1.3	1.0	-0.0	0.1	0.9	1.1
Mouth/teeth dental problems: Dentures	0.4	0.7	1.7	-1.2	-0.1	-0.7	-0.6	1.3
Asthma	0.4	0.7	3.3	0.5	0.8	0.4	-0.3	1.8
Lung cancer (father)	0.4	0.5	1.2	0.0	0.9	0.3	1.0	1.1
Pulse wave Arterial Stiffness index	0.4	0.4	1.1	-0.9	0.6	1.0	-0.3	-0.2
Hair/balding pattern: Pattern 4	0.4	0.9	1.7	-1.3	-1.2	-0.9	-1.1	-0.3
Gout (self-reported)	0.4	0.5	1.1	0.9	0.8	1.0	0.5	0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.4	-0.5	-0.4	-0.7	-1.0	-1.5
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.5	0.7	0.4	0.3	0.9	-1.2
Leg fat percentage (right)	0.4	1.3	3.0	-1.0	-1.2	-1.7	-0.8	-1.3
Worry too long after embarrassment	0.4	0.7	1.3	-0.9	-0.2	-1.1	-1.0	-1.1
Health satisfaction	0.4	0.5	2.7	0.0	0.1	-0.1	0.2	1.6
Shortness of breath walking on level ground	0.4	0.4	1.0	-0.7	0.2	-0.6	-1.0	-0.9
Medication: Omeprazole	0.4	0.5	2.3	0.3	-0.0	-0.6	0.5	-1.5
Mean time to correctly identify matches	0.4	0.8	2.2	-1.3	-0.7	-1.5	0.4	-0.4
Had major operations	0.4	0.5	1.0	0.8	0.7	0.8	0.0	-1.0
Whole body fat-free mass	0.4	2.4	5.8	2.4	1.4	2.2	1.2	-0.6
Diabetes diagnosed by doctor	0.4	0.7	1.0	1.0	1.0	1.0	1.0	-0.2
Illnesses of father: None of the above (group 1)	0.4	0.4	1.1	0.3	-1.0	-0.2	-0.9	-0.8
Whole body water mass	0.4	2.1	5.6	2.4	1.2	2.1	1.1	-0.6
Miserableness	0.4	0.7	1.5	0.5	1.2	0.8	0.6	1.2
Financial situation satisfaction	0.4	0.5	1.3	-1.1	-0.4	-0.3	-0.8	1.0
Leg fat percentage (left)	0.4	1.4	3.2	-1.2	-1.3	-1.8	-1.0	-1.1
Pain experienced in last month	0.4	0.7	2.8	0.5	-1.7	-0.7	-0.1	-0.7
Neuroticism (Nagel 2018)	0.3	0.8	3.8	-0.7	0.6	-0.1	-0.4	1.9
Major Depression (MDD)	0.3	0.4	0.8	0.8	0.8	0.9	0.3	-0.6
HbA1C	0.3	0.3	1.4	-0.2	-0.5	-1.2	-0.4	-0.4
LDL Cholesterol	0.3	0.4	1.0	-0.5	-0.7	-0.9	-0.3	1.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.3	0.2	0.4	0.5	1.1	-0.4
Heel T-Score	0.3	2.4	4.3	-2.0	-1.6	-2.1	-1.9	-0.3
Neuroticism	0.3	0.8	1.9	-1.2	-0.1	-0.6	-1.2	1.4
Number of treatments/medications taken	0.3	0.6	2.7	-0.8	0.2	-0.3	-0.5	1.6
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.5	-0.9	-0.4	-0.5	-0.1	1.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.5	0.0	0.5	0.1	1.2	0.3
Impedance of leg (right)	0.3	1.5	4.8	-0.2	-1.9	-2.2	-0.3	-0.7
Trunk fat percentage	0.3	1.1	2.0	0.7	1.4	1.2	1.1	-1.1
Maternal smoking around birth	0.3	0.4	1.5	-1.2	-0.4	-0.7	-0.6	0.0
Fed-up feelings	0.3	0.5	1.3	-0.5	-0.7	-0.6	-0.7	1.1
High blood pressure (mother)	0.3	0.4	1.4	-0.7	-0.0	-0.3	-1.2	0.3
Impedance of leg (left)	0.3	1.6	5.3	-0.7	-1.9	-2.3	-0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	3.5	-0.1	-0.8	-0.7	0.3	1.9
Financial difficulties in last 2 years	0.3	0.5	1.5	0.1	-0.9	-0.5	-0.4	1.2
Medication: Simvastatin	0.3	0.5	2.2	-0.3	0.6	-0.2	-0.1	1.5
Trunk fat-free mass	0.3	1.8	5.9	2.4	0.8	1.7	1.0	-0.6
Hip circumference	0.3	1.4	3.6	1.5	0.5	1.1	0.8	-1.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	2.3	0.1	0.2	0.3	-1.5	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.5	-0.6	1.2	0.4	0.2	0.1
Medication: Lansoprazole	0.3	0.3	1.3	0.4	-0.2	0.1	-1.1	0.5
Prospective memory result	0.3	0.4	0.9	0.9	0.9	0.7	0.5	0.1
Trunk predicted mass	0.3	1.8	6.0	2.5	0.7	1.7	0.9	-0.6
Breastfed as a baby	0.3	0.4	1.4	-1.2	-0.0	-0.8	-0.5	0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	0.7	-1.1	-0.6	-0.3	-0.3
Medication: Paracetamol	0.3	0.5	2.5	0.0	1.6	0.6	-0.1	0.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.1	0.7	-0.6	-0.1	0.3	-1.5
Glaucoma (self-reported)	0.3	0.4	1.6	0.2	-1.3	-0.7	-0.3	0.4
Exposure to tobacco smoke outside home	0.3	0.4	0.8	-0.5	-0.3	-0.9	-0.8	0.8
Comparative body size at age 10	0.3	0.9	1.8	0.1	-1.1	-1.3	0.9	-1.3
Pulse wave peak to peak time	0.3	0.4	1.8	1.3	-0.1	-0.5	0.6	0.0
Eye problems/disorders: None of the above	0.3	0.3	0.9	0.2	0.4	0.8	0.9	-0.1
Medication: Blood pressure	0.3	0.5	2.0	-0.5	0.1	-0.1	-0.8	1.4
Long-standing illness, disability or infirmity	0.3	0.4	1.4	-0.7	-0.7	-0.4	-0.2	1.2
Breast cancer (self-reported)	0.3	0.3	1.2	0.5	-0.1	0.6	1.1	0.2
Medication: Gliclazide	0.3	0.4	1.4	0.6	-1.2	-0.4	0.4	-0.1
Basal metabolic rate	0.3	1.9	4.8	2.2	1.2	2.0	1.0	-0.5
Age started oral contraceptive pill	0.3	0.4	0.9	0.5	0.6	0.9	0.3	-0.8
Cholesterol lowering medication	0.3	0.5	1.6	-0.0	-0.7	-0.4	-1.3	0.8
Heart disease (siblings)	0.3	0.4	1.6	0.2	1.3	0.5	0.7	0.2
Schizophrenia (2018)	0.2	0.3	1.7	-0.2	-0.5	-0.1	-1.3	-0.2
Ulcerative Colitis (UC)	0.2	0.4	1.2	-1.1	-0.4	-0.9	-0.0	0.4
Prostate Cancer	0.2	0.3	1.5	0.4	0.1	-0.0	-0.4	1.2
Age at First Birth	0.2	0.3	0.8	0.6	0.8	0.9	-0.3	-0.3
Crohns Disease (2012)	0.2	0.2	0.7	0.5	0.5	0.3	0.4	-0.8
HDL Cholesterol	0.2	0.4	0.8	-0.4	-0.8	-0.8	-0.4	-0.9
Schizophrenia (2014)	0.2	0.5	2.2	-0.7	-0.6	-0.4	-1.5	0.2
Blood Eosinophil Count	0.2	1.9	4.4	2.1	1.2	1.9	1.4	-0.1
BMI	0.2	1.3	3.3	-0.4	-1.7	-1.8	-1.1	-0.2
Systolic Blood Pressure	0.2	1.1	2.7	-1.6	-0.6	-1.6	-1.0	-0.0
Cardiovascular Disease	0.2	0.6	1.0	-0.6	-0.9	-0.7	-1.0	0.8
Chronotype (morning person)	0.2	0.5	1.4	-1.0	0.0	-0.3	0.5	1.2
Sensitivity / hurt feelings	0.2	0.3	0.9	-0.1	0.6	0.7	-0.1	0.9
Medication for hormone replacement therapy	0.2	0.2	0.8	-0.7	0.9	0.1	0.4	-0.0
Vitamin and mineral supplements	0.2	0.2	0.8	0.9	-0.4	0.5	0.0	0.5
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.4	-0.7	-0.8	-0.6	-0.3
Supplements: Glucosamine	0.2	0.2	0.7	0.0	0.8	0.3	-0.2	-0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	0.6	0.3	0.2	-0.8	-0.5
Medication: Levothyroxine sodium	0.2	0.4	1.8	0.0	0.2	-0.3	-0.4	-1.4
Qualifications: None of the above	0.2	0.5	1.4	-0.8	-0.0	-0.8	0.2	1.2
Pain all over the body in last month	0.2	0.2	0.6	0.1	0.5	0.8	0.4	0.6
Fluid intelligence score	0.2	0.4	1.3	-0.2	0.8	1.1	-0.4	0.1
Neuroticism score	0.2	0.4	1.5	-0.8	-0.0	-0.3	-0.7	1.2
Worrier / anxious feelings	0.2	0.5	1.3	0.4	0.8	1.1	0.2	0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	1.2	0.3	0.6	0.3	1.0
Tense / ‘highly strung’	0.2	0.3	0.7	-0.5	0.8	0.1	0.3	0.8
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	0.0	-0.7	-0.6	-0.5	-0.1
Qualifications: College or University degree	0.2	0.7	2.3	1.5	-0.5	0.4	0.5	-1.0
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.8	0.2	0.3	-0.1	-0.9	0.5
Medication: Ibuprofen	0.2	0.2	0.6	-0.7	0.6	0.1	0.3	0.6
Whole body fat mass	0.2	0.8	1.4	1.0	1.0	1.0	0.8	-1.2
Pulse rate, automated reading	0.2	0.5	2.6	-0.3	-0.3	-0.1	-0.5	1.6
Overall health rating	0.2	0.4	1.9	0.1	0.3	0.4	0.3	1.4
Chest pain or discomfort	0.2	0.3	0.5	0.6	-0.5	-0.6	-0.7	0.3
Supplements: Vitamin C	0.2	0.2	0.6	0.1	0.4	-0.3	-0.7	-0.8
Hypertension (Self-reported)	0.2	0.5	1.4	-0.4	0.0	-0.3	-1.1	1.2
Illnesses of siblings: Diabetes	0.2	0.2	0.7	0.0	0.8	0.4	-0.4	0.4
Qualifications: nursing, teaching	0.2	0.3	0.4	0.6	0.1	0.6	0.6	-0.6
Osteoarthritis (self-reported)	0.2	0.2	1.0	-1.0	0.3	0.0	0.3	-0.1
Guilty feelings	0.2	0.3	0.9	-0.7	-0.2	-0.3	-0.5	0.9
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	-0.3	-0.4	-0.6	0.2	0.8
Medication: Paracetamol	0.2	0.3	1.1	-0.3	1.0	0.1	-0.5	0.6
Medication: Atorvastatin	0.2	0.3	0.7	-0.3	-0.6	-0.5	-0.8	0.4
Illnesses of father: High blood pressure	0.2	0.2	1.0	-0.0	-0.0	-0.3	-0.2	-1.0
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.7	0.6	0.6	0.8	0.5	0.2
Fractured/broken bones in last 5 years	0.2	0.2	0.6	-0.6	0.8	0.4	0.3	0.5
Diastolic blood pressure, automated reading	0.2	0.7	1.8	1.3	1.0	0.7	0.8	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.7	0.8	0.0	-0.4	0.6	-0.8
Impedance of whole body	0.2	0.9	2.7	0.7	1.1	0.9	1.6	-0.7
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.5	0.0	-0.3	-0.6	0.1
Crohns Disease (2017)	0.1	0.3	1.0	-0.4	0.2	0.1	1.0	-0.7
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	-0.8	-0.2	-0.5	0.3	0.2
Ovarian Cancer	0.1	0.2	0.6	0.2	-0.6	0.1	-0.8	0.1
Mean Putamen Volume	0.1	0.1	0.3	0.4	-0.2	0.3	-0.5	-0.3
Ulcerative Colitis	0.1	0.1	0.5	0.3	-0.2	-0.2	0.7	0.0
Blood Platelet Count	0.1	0.9	2.9	-1.6	1.7	0.4	-0.0	-0.3
Blood White Count	0.1	0.4	1.5	-1.2	0.9	0.1	-0.3	-0.1
Hypothyroidism (self reported)	0.1	0.1	0.4	0.6	0.0	0.2	-0.1	-0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	0.4	0.7	0.2	0.7	0.3
Hand grip strength (left)	0.1	0.3	1.4	1.2	-0.0	0.6	0.5	0.4
Relative age of first facial hair	0.1	0.1	0.4	-0.2	0.5	-0.0	0.0	-0.6
Systolic blood pressure, automated reading	0.1	0.2	0.5	-0.2	0.7	-0.2	0.6	0.2
Diabetes (mother)	0.1	0.1	0.4	-0.1	0.3	-0.0	-0.6	-0.1
Hand grip strength (right)	0.1	0.4	1.7	1.3	-0.2	0.6	-0.1	0.5
Townsend deprivation index at recruitment	0.1	0.2	0.5	-0.7	0.3	-0.3	0.6	0.2
Age when periods started (menarche)	0.1	0.2	0.5	0.7	0.5	0.0	0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	0.1	-0.3	-0.4	0.8	0.5
High blood pressure	0.1	0.3	1.1	-0.1	-0.1	-0.3	-1.0	0.7
Body mass index (BMI)	0.1	0.2	0.6	-0.4	-0.4	-0.5	-0.8	-0.5
Nervous feelings	0.1	0.2	0.8	-0.9	-0.4	-0.2	-0.4	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.9	0.4	0.5	0.1	-0.0	0.9
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	0.6	-0.4	-0.3	0.4	-0.0
Had menopause	0.1	0.1	0.4	-0.1	0.2	0.2	0.0	0.7
Mouth/teeth dental problems	0.1	0.2	0.5	-0.6	-0.5	-0.2	0.1	0.7
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	0.7	-0.1	0.6	0.3	0.4
Arm fat percentage (right)	0.1	0.4	1.2	0.3	0.7	0.7	0.4	-1.1
Falls in the last year	0.1	0.2	0.5	0.5	0.7	0.4	-0.0	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	0.6	-0.2	-0.5	0.1	0.4
Illnesses of mother	0.1	0.1	0.4	0.2	0.0	0.0	0.5	-0.7
Arm fat mass (right)	0.1	0.4	0.8	0.7	0.7	0.8	0.2	-0.9
Body fat percentage	0.1	0.3	1.3	0.1	0.6	0.2	0.3	-1.1
Arm fat-free mass (right)	0.1	0.7	2.6	1.6	0.4	1.0	0.3	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.4	-0.0	0.2	0.4	-0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.1	0.7	0.1	-0.1	0.6
Angina (self-reported)	0.1	0.1	0.4	-0.4	-0.1	-0.6	0.2	-0.1
Medication: Seretide 50 evohaler	0.1	0.2	0.4	0.6	-0.4	-0.6	0.3	-0.2
Heart disease (mother)	0.1	0.2	0.7	0.0	-0.4	0.1	-0.2	-0.8
Leg fat mass (right)	0.1	0.2	1.3	0.2	-0.1	-0.3	0.1	-1.1
Arm predicted mass (right)	0.1	0.4	1.6	1.3	0.1	0.7	0.0	-0.4
Age at last live birth	0.1	0.2	0.6	0.8	-0.6	0.2	0.2	-0.3
Leg pain on walking	0.1	0.1	0.2	0.5	0.4	0.3	-0.2	-0.4
Arm fat percentage (left)	0.1	0.4	1.0	0.2	0.8	0.7	0.5	-1.0
Mood swings	0.1	0.2	0.9	0.3	0.4	0.2	-0.2	0.9
Arm fat mass (left)	0.1	0.4	1.1	0.6	0.6	0.8	0.3	-1.0
Commuting to job workplace: Public transport	0.1	0.1	0.4	0.3	-0.1	0.1	-0.6	-0.0
Arm fat-free mass (left)	0.1	0.5	2.3	1.5	-0.1	0.8	0.1	-0.4
Irritability	0.1	0.2	0.9	0.4	-0.0	-0.7	0.2	0.9
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.8	0.4	-0.1	0.2	0.7	-0.9
Arm predicted mass (left)	0.1	0.4	1.9	1.4	-0.1	0.6	-0.1	-0.2
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	-0.1	0.4	0.3	-0.5	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.0	0.4	1.0	-0.4	-0.5	0.1	-0.9	-1.0
Hair Pigment	0.0	0.2	0.8	-0.5	-0.2	0.1	-0.1	-0.9
Tanning	0.0	0.4	1.4	-0.8	-0.4	-1.2	-0.1	-0.2
Angina	0.0	0.0	0.2	-0.1	0.2	-0.4	0.2	-0.0
Emphysema/chronic bronchitis	0.0	0.1	0.2	0.0	0.4	0.3	-0.2	0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.1	0.2	0.3	-0.1	0.1	0.5	-0.0
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.2	0.3	-0.0	-0.4	0.1	0.1
Leg fat mass (left)	0.0	0.2	0.9	-0.0	-0.2	-0.4	-0.0	-0.9

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