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chr3:36,170,609-38,995,532

Best TWAS P=1.49e-35 · Best GWAS P=2.06e-35 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EPM2AIP1	0.03	0.01	enet	32	0.02	3.6e-03	6.4	5.7	1.1e-08	0.02	0.08	0.23	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LRRFIP2	0.04	0.00	bslmm	481	0.02	3.5e-03	-7.3	-5.2	1.8e-07	0.01	0.43	0.15	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PLCD1	0.07	0.02	lasso	4	0.03	4.2e-04	5.5	10.1	4.6e-24	0.73	0.01	0.97	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TRANK1	0.08	0.01	blup	437	0.03	5.1e-05	-7.2	6.1	1.3e-09	-0.05	0.11	0.88	FALSE
5	CommonMind	Brain Pre-frontal Cortex	VILL	0.26	0.38	lasso	3	0.38	1.9e-49	11.3	-11.8	6.9e-32	-0.99	0.03	0.97	FALSE
6	GTEx	Artery Aorta	LRRFIP2	0.21	0.17	lasso	7	0.20	4.4e-11	6.9	-7.1	1.3e-12	0.01	0.82	0.18	FALSE
7	GTEx	Artery Tibial	LRRFIP2	0.08	0.08	lasso	5	0.08	1.0e-06	-7.2	-6.8	9.3e-12	0.03	0.71	0.28	FALSE
8	GTEx	Brain Caudate basal ganglia	VILL	0.35	0.38	lasso	8	0.33	3.9e-10	11.4	-12.0	4.1e-33	-0.97	0.01	0.99	FALSE
9	GTEx	Brain Cortex	VILL	0.33	0.29	lasso	2	0.25	1.8e-07	11.5	-11.8	3.6e-32	-0.89	0.22	0.78	TRUE
10	GTEx	Brain Frontal Cortex BA9	VILL	0.31	0.30	enet	11	0.34	7.9e-10	11.7	-12.3	7.2e-35	-0.86	0.06	0.94	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	VILL	0.31	0.13	lasso	6	0.12	5.2e-04	11.4	-12.4	1.5e-35	-0.86	0.10	0.69	TRUE
12	GTEx	Brain Putamen basal ganglia	VILL	0.38	0.31	lasso	7	0.26	7.9e-07	11.4	-10.6	2.2e-26	-0.95	0.04	0.90	FALSE
13	GTEx	Cells Transformed fibroblasts	LRRFIP2	0.12	0.07	enet	18	0.09	2.4e-07	7.0	-7.2	5.6e-13	0.01	0.79	0.21	FALSE
14	GTEx	Colon Sigmoid	LRRFIP2	0.13	0.00	lasso	5	0.00	2.1e-01	-7.2	-6.1	1.1e-09	0.05	0.20	0.09	TRUE
15	GTEx	Esophagus Gastroesophageal Junction	LRRFIP2	0.13	0.16	enet	25	0.07	1.8e-03	-7.2	-7.0	2.7e-12	0.03	0.66	0.30	FALSE
16	GTEx	Esophagus Mucosa	VILL	0.28	0.02	lasso	5	0.04	2.0e-03	8.6	6.5	6.4e-11	0.70	0.02	0.96	FALSE
17	GTEx	Esophagus Mucosa	GOLGA4	0.21	0.22	lasso	6	0.23	1.2e-15	5.2	-5.8	7.5e-09	0.05	1.00	0.00	FALSE
18	GTEx	Esophagus Muscularis	LRRFIP2	0.16	0.17	enet	11	0.13	4.7e-08	-7.2	-7.4	1.1e-13	0.02	0.69	0.31	FALSE
19	GTEx	Muscle Skeletal	MLH1	0.04	0.04	lasso	2	0.01	1.5e-02	-7.2	-7.2	4.4e-13	0.01	0.05	0.94	FALSE
20	GTEx	Muscle Skeletal	LRRFIP2	0.11	0.10	enet	15	0.13	1.1e-12	-7.1	-7.2	8.7e-13	0.02	0.75	0.25	FALSE
21	GTEx	Nerve Tibial	LRRFIP2	0.09	0.10	lasso	2	0.07	5.8e-06	-7.2	-7.4	1.8e-13	0.02	0.66	0.34	FALSE
22	GTEx	Prostate	LRRFIP2	0.15	-0.01	enet	20	0.00	3.5e-01	-7.3	-7.7	1.3e-14	0.02	0.12	0.08	TRUE
23	GTEx	Skin Not Sun Exposed Suprapubic	LRRFIP2	0.13	0.07	enet	23	0.12	6.9e-07	-7.3	7.5	7.4e-14	0.05	0.70	0.26	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	GOLGA4	0.09	0.02	enet	4	0.01	5.3e-02	5.2	-5.3	1.2e-07	0.04	0.21	0.05	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	PLCD1	0.11	0.10	lasso	2	0.07	1.5e-04	7.5	7.6	3.5e-14	-0.05	0.68	0.02	TRUE
26	GTEx	Testis	LRRFIP2	0.12	0.05	enet	25	0.11	1.6e-05	4.1	-5.5	4.6e-08	-0.04	0.67	0.27	FALSE
27	GTEx	Testis	OXSR1	0.17	0.01	lasso	4	0.03	2.3e-02	-5.0	-5.3	1.2e-07	-0.01	0.07	0.10	FALSE
28	GTEx	Thyroid	LRRFIP2	0.38	0.55	enet	31	0.60	3.8e-56	-7.3	-7.1	1.1e-12	0.00	0.59	0.41	FALSE
29	GTEx	Whole Blood	LRRFIP2	0.04	0.05	lasso	3	0.04	1.4e-04	-7.2	7.0	2.0e-12	0.01	0.64	0.26	FALSE
30	METSIM	Adipose	ITGA9	0.08	0.05	bslmm	532	0.06	9.3e-10	3.7	6.0	2.6e-09	0.28	1.00	0.00	TRUE
31	NTR	Blood	GOLGA4	0.02	0.00	bslmm	468	0.00	1.8e-02	-4.9	-5.2	1.9e-07	0.00	0.23	0.04	FALSE
32	NTR	Blood	LRRFIP2	0.03	0.03	lasso	5	0.04	8.6e-12	-7.1	7.4	1.2e-13	-0.01	0.72	0.28	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	LRRFIP2	0.09	0.09	lasso	5	0.08	7.4e-11	-7.2	-7.3	3.7e-13	0.03	0.71	0.29	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	VILL	0.34	0.46	lasso	3	0.46	3.1e-65	11.3	-11.5	1.3e-30	-0.96	1.00	0.00	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	TRANK1	0.05	0.05	lasso	4	0.02	4.1e-04	5.9	5.8	5.1e-09	0.03	0.29	0.63	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	PLCD1	0.13	0.12	bslmm	421	0.12	6.6e-15	11.5	-11.9	7.4e-33	-0.80	0.14	0.86	FALSE
37	YFS	Blood	GOLGA4	0.01	0.00	blup	460	0.01	2.2e-03	-7.2	-6.9	7.1e-12	0.01	0.66	0.03	FALSE
38	YFS	Blood	PLCD1	0.07	0.08	enet	15	0.08	8.0e-25	11.5	12.4	3.2e-35	0.85	0.11	0.89	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	LRRFIP2	0.02	0.03	blup	73	0.03	3.0e-06	-7.2	-7.5	8.2e-14	0.01	0.05	0.95	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	PLCD1	0.01	0.02	blup	55	0.01	7.3e-03	12.2	11.5	8.0e-31	0.88	0.02	0.90	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LRRFIP2	0.02	0.01	blup	73	0.02	5.7e-03	-7.2	-7.4	1.7e-13	0.00	0.06	0.88	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRFIP2	0.03	0.01	enet	7	0.01	1.8e-02	-7.1	-6.3	3.3e-10	0.02	0.04	0.55	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	VILL	0.03	0.01	blup	52	0.01	1.5e-02	11.7	-11.1	1.0e-28	-0.73	0.02	0.49	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	CTDSPL	0.04	0.01	blup	78	0.02	1.0e-03	11.5	-8.9	4.6e-19	-0.66	0.04	0.81	FALSE
45	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LRRFIP2	0.09	0.12	enet	9	0.09	1.5e-04	6.9	-7.3	3.8e-13	0.01	0.08	0.87	TRUE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	PLCD1	0.05	0.04	enet	8	0.04	6.3e-05	12.2	12.0	3.0e-33	0.81	0.10	0.89	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	EPM2AIP1	0.04	0.04	blup	31	0.04	8.3e-05	7.0	-7.1	1.6e-12	0.00	0.02	0.97	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	LRRFIP2	0.24	0.38	enet	14	0.38	2.1e-38	-7.2	-7.2	7.5e-13	0.00	0.04	0.96	FALSE