Best TWAS P=1.04e-24 · Best GWAS P=3.63e-78 conditioned to 1.13e-55
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells Transformed fibroblasts | PPP4R2 | 0.18 | 0.19 | lasso | 4 | 0.19 | 5.9e-14 | -7.1 | -7.1 | 9.6e-13 | -0.03 | 0.01 | 0.99 | FALSE |
2 | GTEx | Muscle Skeletal | PPP4R2 | 0.11 | 0.07 | enet | 8 | 0.11 | 1.6e-10 | -7.1 | -5.9 | 3.2e-09 | -0.02 | 0.01 | 0.99 | FALSE |
3 | GTEx | Uterus | FOXP1 | 0.56 | 0.08 | lasso | 6 | 0.07 | 1.7e-02 | -2.0 | -5.7 | 9.6e-09 | 0.01 | 0.08 | 0.27 | TRUE |
4 | GTEx | Whole Blood | RYBP | 0.13 | 0.18 | lasso | 1 | 0.17 | 1.1e-15 | -7.8 | -7.8 | 5.0e-15 | 0.54 | 1.00 | 0.00 | FALSE |
5 | NTR | Blood | EBLN2 | 0.04 | 0.02 | lasso | 8 | 0.02 | 1.3e-08 | -7.1 | 7.1 | 1.1e-12 | 0.06 | 0.01 | 0.99 | FALSE |
6 | NTR | Blood | RYBP | 0.05 | 0.03 | lasso | 5 | 0.04 | 5.4e-14 | -8.8 | -10.3 | 1.0e-24 | 0.58 | 1.00 | 0.00 | TRUE |
7 | ROSMAP | Brain Pre-frontal Cortex | PPP4R2 | 0.16 | 0.10 | lasso | 8 | 0.12 | 1.2e-15 | -7.1 | -7.5 | 4.4e-14 | -0.02 | 0.01 | 0.99 | TRUE |
8 | YFS | Blood | RYBP | 0.25 | 0.16 | enet | 33 | 0.23 | 7.8e-75 | 7.1 | -10.0 | 1.2e-23 | 0.48 | 1.00 | 0.00 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FLJ10213 | 0.01 | 0.01 | lasso | 1 | 0.01 | 5.4e-03 | 6.8 | 6.8 | 1.0e-11 | 0.04 | 0.01 | 0.97 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FLJ10213 | 0.03 | 0.01 | blup | 37 | 0.02 | 2.8e-03 | 6.5 | 7.1 | 9.4e-13 | 0.03 | 0.02 | 0.68 | FALSE |
11 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FLJ10213 | 0.05 | 0.06 | lasso | 2 | 0.05 | 3.8e-04 | 6.6 | 6.6 | 3.3e-11 | 0.04 | 0.05 | 0.55 | FALSE |
12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RYBP | 0.10 | 0.00 | blup | 62 | 0.04 | 5.4e-04 | -7.7 | -9.5 | 2.4e-21 | 0.51 | 0.05 | 0.20 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FLJ10213 | 0.03 | 0.02 | blup | 38 | 0.03 | 4.6e-04 | -7.2 | 5.6 | 2.4e-08 | 0.04 | 0.01 | 0.98 | FALSE |