Hub : Genes

RYBP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.1780	0.0630	5.6e-03	-0.003	NA	0.011	NA	0.019	5.1e-01	NA	7.3e-02	NA	3.1e-02
2	GTEx	Whole Blood	0.1280	0.0370	3.2e-04	0.183	NA	0.155	NA	0.172	1.3e-16	NA	3.8e-14	NA	1.1e-15
3	NTR	Blood	0.0529	0.0127	3.2e-07	0.031	0.024	0.041	0.036	0.044	1.9e-10	2.5e-08	4.7e-13	8.3e-12	5.4e-14
4	ROSMAP	Brain Pre-frontal Cortex	0.2350	0.0464	1.2e-08	0.170	0.099	0.178	0.173	0.167	2.6e-21	1.1e-12	2.4e-22	1.3e-21	6.9e-21
5	YFS	Blood	0.2516	0.0283	0.0e+00	0.165	0.197	0.233	0.206	0.227	1.6e-51	2.8e-62	7.8e-75	1.4e-65	7.7e-73
6	TCGA	Ovarian Serous Cystadenocarcinoma	0.0970	0.0430	6.2e-04	-0.003	0.045	0.024	NA	0.019	6.0e-01	5.4e-04	8.7e-03	NA	1.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.8	1.3	5.1	-0.7	-1.2	-0.9	2.3	0.2	-0.0
Bipolar Disorder or Schizophrenia	0.5	1.3	2.7	0.4	-1.6	-1.3	1.7	-0.4	0.7
Depressed Affect (Nagel 2018)	0.5	1.0	4.0	-2.0	-0.7	0.1	-1.3	0.2	0.2
Depression (Nagel 2018)	0.9	1.3	4.3	-2.1	-0.3	0.8	0.6	1.5	0.4
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.4	1.3	-1.0	-1.3	0.8	-1.6	-0.6
Neuroticism (Nagel 2018)	0.3	0.8	1.7	-1.3	-0.0	0.9	0.8	1.2	0.2
Schizophrenia (2018)	0.4	0.8	1.3	1.1	-1.0	-0.9	0.3	-0.6	0.9
Schizophrenia vs Biploar Disorder	1.2	1.6	2.9	0.8	1.6	1.1	-1.7	0.1	1.5
Worry (Nagel 2018)	0.6	1.3	3.9	-1.7	0.4	0.4	2.0	0.7	-0.3
Alzheimer’s Disease (in mother)	0.8	0.9	2.5	-1.1	0.7	0.7	1.6	0.8	0.4
Alzheimer’s Disease (in father)	0.4	0.4	1.3	-0.6	-0.6	0.3	1.1	0.4	-0.5
Alzheimer’s Disease (including proxy)	0.7	1.0	2.9	-1.4	0.1	0.5	1.7	0.7	-0.3
Crohns Disease (2017)	0.1	0.3	0.8	0.5	0.6	0.4	-0.9	0.0	-0.1
Irritable Bowel Disease (IBD)	0.5	1.1	3.3	0.1	1.5	1.8	0.5	0.9	0.1
Ulcerative Colitis (UC)	1.1	2.1	4.0	-0.5	1.3	2.0	1.9	1.7	0.4
Major Depression (MDD)	0.3	0.3	1.0	-0.0	-0.1	0.3	0.4	1.0	0.8
Reaction Time	2.0	3.8	7.7	-0.1	-2.8	-2.5	2.3	-0.7	-1.7
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.4	1.4	-1.0	-1.5	0.4	-1.5	-0.5
Breast Cancer	0.4	0.9	3.3	0.4	0.2	0.7	0.2	1.8	1.1
Ovarian Cancer	0.8	1.0	3.2	-0.5	-1.8	-1.4	0.6	-0.2	-0.8
Prostate Cancer	0.3	0.5	1.2	0.5	1.1	-0.0	-0.6	-0.9	0.5
Age at First Birth	1.5	2.2	7.3	-0.1	-0.6	-1.6	-1.6	-2.7	-0.9
Bipolar Disorder (2011)	3.0	2.9	7.8	0.2	-2.8	-2.6	1.1	-1.1	0.0
Body Mass Index (BMI) (2010)	2.9	4.0	8.8	-0.3	1.8	2.5	-1.0	2.1	3.0
Coronary Artery Disease (CAD)	0.2	0.2	0.7	-0.9	-0.3	-0.4	-0.3	-0.1	0.4
Crohns Disease (2012)	0.5	0.8	4.7	2.2	-0.0	0.0	-0.3	-0.4	-0.0
Mean Putamen Volume	0.5	0.5	1.4	1.2	0.7	0.4	-1.0	-0.3	0.2
Fasting Glucose	0.9	1.1	2.8	-0.1	-1.5	-0.9	1.7	0.4	-0.7
HbA1C	0.7	0.8	2.0	-0.8	-1.1	-0.9	1.4	0.2	0.2
HDL Cholesterol	1.6	2.6	6.9	1.0	-2.6	-1.8	0.8	-1.3	-1.4
LDL Cholesterol	0.2	0.3	1.4	-1.2	0.0	0.3	-0.3	0.6	0.4
Lupus	1.1	1.7	3.5	0.4	1.5	1.9	1.0	1.7	0.7
Neuroticism (2016)	0.6	0.9	2.7	-0.7	-1.1	0.3	0.8	1.6	-0.2
Primary Biliary Cirrhosis	1.8	2.6	11.5	3.4	-0.8	-0.8	-0.4	-1.5	-0.4
Rheumatoid Arthritis	0.2	0.3	0.7	-0.1	-0.3	0.3	-0.7	0.9	0.3
Schizophrenia (2014)	0.4	0.9	3.8	0.4	-0.8	-0.8	0.3	-0.4	2.0
Triglycerides	0.4	0.7	1.8	-0.1	1.1	0.8	-1.4	0.3	-0.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.8	-0.1	-0.9	-1.3	-0.7	-1.0	-1.2
Ulcerative Colitis	0.8	1.1	3.3	-0.1	0.0	1.1	1.8	1.5	-0.3
Blood Eosinophil Count	0.2	1.8	5.9	-0.1	1.0	1.2	-2.4	-1.3	-0.9
Blood Platelet Count	0.5	5.4	13.3	-0.1	1.5	3.4	1.6	3.6	1.7
Blood Red Count	0.9	8.6	15.7	0.2	3.3	4.0	-2.4	3.6	2.5
Blood White Count	0.6	4.6	7.8	-2.2	-2.7	-2.1	1.7	-0.2	-2.8
Heel T-Score	1.3	10.6	17.6	2.9	4.1	4.2	-2.5	2.2	3.0
BMI	0.8	4.9	10.1	-0.8	3.0	3.2	-0.9	2.2	1.9
Height	3.1	60.2	106.1	-1.8	-7.8	-10.3	0.5	-10.0	-9.5
Waist Hip Ratio (WHR)	0.6	2.8	5.1	-0.9	-2.0	-2.3	-0.7	-2.2	-1.2
Systolic Blood Pressure	0.4	1.8	3.3	-1.7	0.3	1.2	1.1	1.4	1.8
Smoking Status	1.7	4.1	6.8	-1.9	-2.6	-2.1	-1.1	-1.9	-2.3
Allergy or Eczema	2.8	7.3	16.3	1.3	3.8	4.0	-0.8	2.0	2.5
Cardiovascular Disease	0.4	1.4	3.8	-1.9	0.7	0.9	1.5	0.9	0.3
Hypothyroidism (self reported)	0.8	1.7	7.3	-0.5	-1.3	-0.7	-0.4	-0.8	-2.7
Respiratory disease	0.6	1.3	4.3	-0.2	0.9	1.3	-2.1	0.1	0.8
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.4	-0.6	-1.6	-1.1	1.1	-0.4	-1.2
Lung FEV1/FVC ratio	0.3	1.7	3.9	2.0	-1.5	-1.5	-0.1	-0.8	-1.2
Lung FVC	0.1	0.3	1.0	0.5	-0.1	0.5	0.2	1.0	0.6
Neuroticism	0.3	0.8	2.5	-1.6	-0.6	0.2	1.0	0.5	-0.5
Chronotype (morning person)	0.4	1.0	3.2	-0.3	-1.0	-1.8	0.2	-1.4	0.0
Hair Pigment	0.2	4.8	7.8	-0.9	-2.6	-2.8	2.6	-1.7	-2.1
Tanning	0.1	0.9	2.0	-0.8	-0.6	-0.5	-1.4	-1.3	0.4
Hand grip strength (left)	0.7	2.0	4.2	0.5	-1.6	-2.1	1.2	-1.3	-1.2
Number of treatments/medications taken	1.0	1.8	8.0	-2.8	-0.8	-0.3	0.9	-0.3	-1.2
Average weekly spirits intake	0.3	0.3	0.7	0.8	0.2	0.1	-0.7	0.4	-0.8
Sensitivity / hurt feelings	0.2	0.4	1.0	-0.8	-0.6	0.1	-0.5	-0.3	-1.0
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.3	-1.0	-0.3	0.2	-0.5	-0.4	-1.2
Hearing difficulty/problems: Yes	0.4	0.7	3.6	-1.9	0.1	0.2	0.3	0.5	0.1
Relative age of first facial hair	0.3	0.6	2.2	0.8	0.7	-0.3	-0.3	-1.5	-0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.6	-0.5	-1.1	-0.9	0.4	-0.9	-1.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.0	1.4	0.5	0.8	0.0	0.5	0.7
Ever had hysterectomy (womb removed)	0.3	0.3	0.7	0.8	-0.6	-0.0	-0.2	-0.2	-0.8
Systolic blood pressure, automated reading	0.3	0.8	2.2	-0.0	0.9	0.8	-1.5	-0.5	1.0
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	8.7	-3.0	0.1	-0.1	1.3	-0.1	-0.5
Angina	2.4	3.1	5.2	-1.9	1.9	2.3	0.4	2.2	1.1
Medication for hormone replacement therapy	0.6	0.6	1.0	0.9	0.9	0.9	-0.4	0.5	1.0
Vitamin and mineral supplements	1.2	1.7	4.7	0.3	2.2	1.8	0.1	1.4	0.5
Supplements: Zinc	0.3	0.3	1.1	0.1	-0.2	0.4	0.6	1.1	-0.3
Medication: Co-codamol	0.8	0.9	1.9	-0.4	-1.1	-0.9	0.8	-0.7	-1.4
Medication: Metformin	0.5	0.7	2.8	-1.7	0.8	0.8	0.1	0.1	0.0
Diabetes (father)	0.4	0.5	1.2	-0.6	-0.2	-0.5	-0.8	-1.1	-0.5
Diabetes (mother)	0.7	0.9	2.5	0.3	-0.6	-0.9	-0.2	-1.3	-1.6
Severe depression (siblings)	2.0	2.2	4.0	-1.6	-2.0	-1.5	2.0	-0.7	-0.5
Pack years adult smoking proportion	1.2	1.8	4.0	-0.4	-1.9	-2.0	-0.4	-1.6	-0.2
Impedance of leg (right)	1.1	5.1	10.2	0.6	-2.1	-2.9	-2.3	-3.2	-1.4
Leg fat-free mass (left)	0.3	1.4	3.3	-1.3	-0.5	-1.0	1.8	-0.6	-1.4
Trunk fat percentage	0.2	0.8	2.9	-1.7	0.5	-0.0	0.4	0.0	-1.1
Hand grip strength (right)	0.9	2.5	5.3	0.3	-1.8	-2.3	1.0	-1.5	-1.8
Townsend deprivation index at recruitment	1.2	1.7	3.3	-1.1	-1.4	-1.8	-0.4	-1.6	-0.8
Current tobacco smoking	1.4	2.3	3.3	-1.5	-1.8	-1.6	-1.4	-1.2	-1.5
Average weekly fortified wine intake	4.0	4.6	8.7	-1.2	-2.9	-2.5	-0.6	-1.9	-2.7
Maternal smoking around birth	1.2	1.7	3.5	-0.2	-1.6	-1.9	-1.1	-1.6	0.7
Fed-up feelings	0.3	0.5	1.3	-0.7	0.2	0.9	-1.1	0.5	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	6.5	-2.5	0.5	1.6	-0.1	1.2	-0.0
Relative age voice broke	0.3	0.5	1.3	1.1	0.6	-0.2	-0.1	-0.5	-1.1
Taking other prescription medications	0.4	0.7	1.6	-1.2	-0.1	-0.3	-0.7	-1.1	-0.8
Age when periods started (menarche)	0.7	1.7	3.3	-0.7	1.0	1.4	1.1	1.4	1.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.6	0.0	-0.1	-0.7	-0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	0.6	-0.2	0.1	-1.0	0.3	0.8
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.8	0.0	1.4	1.7	1.7	1.2	0.4
Qualifications: CSEs or equivalent	1.0	1.3	6.8	0.6	-0.5	-0.5	-0.1	-0.5	-2.6
Serious illness, injury or assault to yourself	0.6	0.7	1.6	0.1	1.1	1.3	0.4	1.1	0.6
High blood pressure	0.1	0.4	1.7	-1.3	0.0	0.2	0.2	-0.3	0.8
Hayfever, allergic rhinitis or eczema	1.7	3.7	7.8	0.8	2.5	2.8	-1.6	1.1	1.9
Multivitamins +/- minerals	0.6	0.7	2.9	0.7	-1.7	-0.9	-0.0	-0.4	-0.1
Stomach or abdominal pain in last month	2.8	3.5	8.2	-0.5	2.8	2.9	0.2	2.0	1.0
Supplements: Glucosamine	0.4	0.5	1.8	-1.3	-1.0	-0.5	-0.4	-0.4	0.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.9	1.1	-0.3	0.5	1.4	1.3	-0.6
Medication: Atenolol	0.4	0.5	2.5	-1.6	-0.1	0.3	-0.1	0.7	0.2
Medication: Levothyroxine sodium	0.7	1.3	5.9	0.4	-1.1	-0.6	0.0	-0.3	-2.4
Sitting height	0.8	5.6	10.6	0.6	-2.3	-3.1	1.1	-2.6	-3.3
Chronic bronchitis/emphysema (father)	1.2	1.4	4.0	-0.0	-1.8	-0.9	2.0	0.8	-0.1
High blood pressure (mother)	0.7	0.9	1.7	-1.1	-1.3	-0.9	0.7	-0.4	-1.2
Body mass index (BMI)	0.8	3.4	6.8	-0.9	2.1	2.6	0.6	2.4	1.6
Impedance of leg (left)	1.0	5.0	9.7	1.1	-2.0	-2.7	-2.1	-3.1	-1.9
Leg predicted mass (left)	0.3	1.4	3.7	-1.3	-0.4	-0.9	1.9	-0.4	-1.4
Trunk fat mass	0.2	1.0	2.9	-1.7	0.2	-0.5	0.6	-0.5	-1.4
Waist circumference	0.1	0.5	2.4	-1.6	0.5	0.2	0.0	-0.2	-0.4
Number of incorrect matches in round	1.2	2.0	4.0	1.6	-1.2	-0.8	-2.0	-1.5	-0.9
Past tobacco smoking	1.0	1.8	4.0	-0.0	2.0	1.6	0.9	1.3	1.5
Alcohol usually taken with meals	0.8	1.3	4.5	-2.1	0.5	1.1	0.7	0.9	0.9
Nervous feelings	0.9	1.6	5.0	-2.2	0.1	-0.0	1.7	0.6	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.8	-1.4	-0.5	0.5	1.0	0.7	-1.0
Hearing difficulty/problems with background noise	2.3	3.7	7.2	-2.7	-2.4	-1.5	2.4	0.5	-1.0
Hair/balding pattern: Pattern 2	0.9	1.2	3.9	2.0	0.1	-0.4	-1.2	-0.7	-1.1
Had menopause	0.3	0.4	1.2	-0.2	1.1	0.9	-0.4	0.1	0.3
Had other major operations	0.2	0.2	0.6	0.5	-0.2	-0.0	0.8	-0.1	-0.7
Forced vital capacity (FVC)	1.1	4.1	7.7	1.0	-1.9	-2.8	0.9	-2.3	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	0.9	0.4	0.6	-1.1	0.4	1.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.4	-1.1	-1.1	-0.1	1.2	0.8	0.5
Qualifications: None of the above	0.3	0.6	1.7	-1.3	-0.1	-0.3	-1.3	-0.4	-0.2
Financial difficulties in last 2 years	1.0	1.4	2.4	-1.5	0.8	1.2	1.0	1.4	0.9
Mouth/teeth dental problems	1.3	2.1	5.4	-0.9	-2.3	-1.9	0.8	-0.5	-1.3
Heart attack	1.4	1.8	8.4	-2.9	-0.2	-0.0	1.1	0.7	-0.5
Allergy	1.2	2.7	5.3	-0.2	-2.1	-2.1	2.3	-0.3	-1.5
Pain all over the body in last month	0.3	0.4	1.6	1.3	-0.0	-0.4	0.0	-0.1	-0.6
Diabetes (self-reported)	0.3	0.5	1.4	-1.2	-0.6	-0.7	0.6	-0.8	-0.2
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	5.0	2.0	1.4	1.0	-2.2	-0.2	0.3
Medication: Ramipril	0.5	0.7	2.9	-1.7	-0.0	-0.1	-1.0	-0.3	0.1
Medication: Simvastatin	0.3	0.5	2.2	-0.8	-0.1	-0.1	1.5	0.2	-0.3
Fluid intelligence score	0.6	1.3	2.3	1.3	-1.3	-1.5	0.7	-1.2	0.2
Illnesses of siblings	0.4	0.6	1.2	1.1	0.5	-0.5	-0.3	-1.0	-0.9
Neuroticism score	0.2	0.5	1.7	-1.3	-0.5	0.4	0.5	0.2	-0.8
Weight	0.2	0.9	1.8	-1.3	-0.3	-0.7	1.0	-0.6	-1.3
Impedance of arm (right)	0.9	4.3	8.1	-1.5	-1.5	-2.4	-1.0	-2.5	-2.9
Arm fat percentage (right)	0.3	1.4	2.8	-1.7	1.5	1.4	0.2	1.0	-0.0
Trunk fat-free mass	0.3	1.9	3.6	0.1	-1.1	-1.9	1.0	-1.9	-1.4
Hip circumference	0.1	0.5	1.7	-1.3	0.8	0.4	0.4	0.1	-0.6
Time employed in main current job	4.6	5.3	11.3	0.6	2.6	3.4	1.1	2.7	2.3
Alcohol intake versus 10 years previously	0.9	1.3	4.3	0.5	1.3	0.3	-2.1	-1.2	0.6
Father’s age at death	0.5	0.7	2.4	-1.6	-0.7	-0.3	0.6	-0.6	-0.4
Worrier / anxious feelings	0.1	0.2	0.6	-0.3	0.0	0.5	0.1	0.5	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	4.1	-2.0	0.5	0.9	-0.4	1.0	0.5
Falls in the last year	0.9	1.2	1.8	-1.3	-1.2	-1.2	0.1	-0.9	-1.3
Hair/balding pattern: Pattern 3	0.0	0.1	0.2	0.2	0.4	-0.3	-0.0	-0.1	0.0
Number of live births	1.2	1.7	4.5	-1.3	0.9	1.1	0.6	1.3	2.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	4.6	1.3	-1.3	-2.1	1.0	-1.6	-1.8
Pulse rate	1.0	1.6	4.0	0.9	0.2	0.9	2.0	1.8	0.8
Happiness	0.4	0.5	1.0	0.7	1.0	1.0	-0.5	-0.6	0.4
Noisy workplace	0.2	0.2	0.8	-0.3	0.3	0.2	0.6	0.9	-0.0
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.4	1.8	-0.4	-0.4	0.7	-0.5	-1.1
Serious illness, injury or assault of a close relative in last 2 years	3.2	3.7	6.3	0.5	-2.3	-2.3	-0.1	-2.5	-2.3
Mouth/teeth dental problems: Dentures	0.3	0.5	1.0	-0.7	1.0	0.7	-1.0	-0.3	-0.2
Asthma	2.4	4.7	12.9	0.5	2.3	1.8	-3.6	-0.4	2.5
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	5.3	-0.7	-2.2	-2.3	1.2	-1.4	-1.5
Medication: Cholesterol lowering	0.8	1.2	4.5	-2.1	-0.5	-1.0	0.7	-0.4	-0.8
Depression (self-reported)	0.4	0.5	2.2	-0.0	-0.6	0.1	1.5	0.3	-0.5
Medication: Lansoprazole	3.8	4.4	8.5	-0.7	-2.2	-2.7	0.4	-2.3	-2.9
Prospective memory result	0.2	0.3	0.8	0.9	0.2	0.2	-0.7	0.1	-0.5
Lung cancer (father)	0.4	0.4	2.0	0.4	-0.1	-0.5	-0.3	-0.4	-1.4
Illnesses of mother	0.2	0.2	0.6	0.8	-0.3	-0.3	-0.4	-0.4	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	5.6	0.0	-1.8	-2.3	2.4	-1.1	-1.5
Pulse wave Arterial Stiffness index	1.0	1.1	2.1	0.9	-1.4	-1.4	0.6	-1.2	0.5
Impedance of arm (left)	1.0	4.8	9.0	-1.6	-1.6	-2.8	-0.5	-2.6	-3.0
Arm fat mass (right)	0.1	0.6	1.6	-1.3	0.9	0.7	0.4	0.5	-0.5
Trunk predicted mass	0.3	1.8	3.4	0.1	-1.0	-1.9	1.0	-1.8	-1.4
Standing height	2.7	26.6	50.0	-0.5	-5.1	-7.1	0.9	-6.5	-6.3
Length of working week for main job	3.3	3.7	8.2	-0.1	2.7	2.9	-0.1	1.9	1.7
Exposure to tobacco smoke at home	1.6	1.8	4.1	-1.4	0.7	1.4	0.7	2.0	1.4
Breastfed as a baby	2.8	3.4	6.0	0.4	2.5	2.4	0.0	2.3	1.8
Tense / ‘highly strung’	0.5	0.8	2.3	-0.3	-0.8	-0.4	1.3	-0.4	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.9	-0.3	-1.4	-1.0	0.4	-1.0	-1.4
Hair/balding pattern: Pattern 4	0.6	1.6	4.3	-2.1	-1.2	-0.9	1.1	-1.0	-0.8
Birth weight of first child	1.3	2.3	4.6	1.0	-1.3	-1.4	0.1	-2.1	-2.1
Peak expiratory flow (PEF)	0.1	0.3	0.8	0.3	-0.3	-0.9	0.4	-0.7	-0.2
Pulse wave reflection index	0.8	1.0	2.4	-0.1	-1.6	-1.5	-0.1	-1.1	0.2
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.1	0.4	0.2	-0.1	-1.4	-1.4	-1.4
Loud music exposure frequency	2.1	2.3	5.2	0.1	-1.8	-2.3	-0.0	-1.9	-1.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.6	0.8	0.5	0.4	0.4	-0.1	-0.6
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.3	0.7	1.2	0.8	-0.1	0.5	1.8
Blood clot in the leg (DVT)	1.3	1.7	3.6	-1.6	-0.6	-0.9	1.9	-0.2	-1.7
Medication: Paracetamol	0.2	0.4	1.9	-0.2	-0.2	-0.1	0.1	0.7	1.4
Headache pain in last month	0.9	1.5	2.9	0.9	1.7	1.6	-0.2	1.6	0.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	6.0	2.5	0.3	0.3	-0.2	-0.1	0.4
Glaucoma (self-reported)	1.1	1.3	3.1	-1.0	-1.8	-1.5	-0.4	-1.0	-0.6
Gout (self-reported)	0.7	1.0	1.9	-0.1	-1.4	-1.2	1.3	-0.8	-0.5
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	8.2	-0.5	-1.4	-1.1	-0.7	-1.2	-2.9
Medication: Amlodipine	1.0	1.4	6.0	-2.5	0.4	0.5	1.2	0.2	0.7
Medication: Ventolin 100micrograms inhaler	0.9	1.2	4.8	-0.1	1.2	0.5	-2.2	-0.9	0.1
Birth weight	2.0	4.3	6.8	-1.7	2.3	2.6	2.0	2.5	0.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.7	-1.3	0.6	0.1	-0.2	0.5	0.8
High blood pressure (siblings)	1.3	1.8	4.3	-1.7	-0.9	0.3	2.1	1.7	0.1
Forced vital capacity (FVC), Best measure	1.1	4.2	8.2	-0.2	-2.1	-2.9	2.0	-1.8	-2.2
Body fat percentage	0.2	0.7	2.8	-1.7	0.9	0.6	0.2	0.4	-0.4
Leg fat percentage (right)	0.2	0.7	1.3	-1.1	0.9	1.0	-0.4	0.6	0.9
Arm fat-free mass (right)	0.3	1.5	2.6	0.4	-1.1	-1.6	1.6	-1.2	-1.2
Exposure to tobacco smoke outside home	1.2	1.6	3.9	-1.4	0.4	1.6	0.8	2.0	0.3
Comparative body size at age 10	1.7	4.7	11.4	-2.9	1.1	2.3	0.8	3.4	1.3
Number of full brothers	1.0	1.3	3.1	-1.6	-0.8	0.1	1.8	0.9	0.6
Worry too long after embarrassment	0.4	0.7	1.7	1.3	-0.8	-0.6	0.6	-1.0	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.4	0.4	1.0	-0.1	0.3	0.6
Wheeze or whistling in the chest in last year	0.7	1.3	3.9	-2.0	0.0	0.3	-1.0	-0.7	-1.5
Number of children fathered	1.5	1.7	4.6	-2.1	0.7	0.7	-1.8	0.8	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	-1.2	0.5	0.7	0.8	0.9	0.7
Age at first live birth	1.0	1.8	3.7	1.9	-1.4	-1.7	0.6	-1.2	-0.7
Pulse wave peak to peak time	0.7	0.8	1.7	-1.0	1.3	1.0	-0.5	0.7	-0.8
Health satisfaction	0.2	0.3	1.2	0.1	0.4	0.5	1.1	-0.0	0.4
Shortness of breath walking on level ground	0.3	0.3	1.1	-0.8	0.2	0.0	1.1	0.2	0.5
Qualifications: College or University degree	0.1	0.4	1.1	1.0	0.3	0.0	0.4	0.3	1.0
Eye problems/disorders: None of the above	0.4	0.4	1.4	-0.2	-1.2	-1.1	-0.0	0.2	-0.2
Mouth/teeth dental problems: Loose teeth	2.0	2.3	4.3	0.1	1.7	2.1	-0.7	1.9	1.7
Emphysema/chronic bronchitis	0.8	0.9	1.5	-0.8	-1.2	-1.1	1.2	-0.5	-0.5
Medication for pain relief, constipation, heartburn	0.7	1.3	4.0	2.0	-0.6	-0.6	-1.2	-1.1	0.5
Neck or shoulder pain in last month	0.4	0.5	3.0	-1.7	0.0	-0.3	-0.0	0.5	-0.0
Medication: Blood pressure	0.8	1.5	6.4	-2.5	-0.9	-0.6	1.0	0.0	-0.6
Angina (self-reported)	2.8	3.6	6.1	-2.1	2.0	2.5	0.6	2.4	1.1
Migraine (self-reported)	2.2	2.7	5.3	1.1	-1.9	-2.3	-0.1	-1.6	-1.9
Medication: Ibuprofen	2.2	2.6	5.0	-1.5	-2.2	-2.0	0.9	-1.1	-1.4
Medication: Allopurinol	0.8	1.1	4.2	0.5	-1.0	-0.8	2.0	-0.3	-0.7
Medication: Omeprazole	1.4	1.7	3.4	-1.1	1.6	1.8	0.5	1.6	0.4
Medication: Seretide 50 evohaler	1.1	1.2	2.3	-1.0	-0.8	-0.8	-0.8	-1.5	-1.5
Mean time to correctly identify matches	1.0	1.9	3.6	-0.1	-1.9	-1.6	1.4	-0.8	-1.6
Heart disease (mother)	0.1	0.1	0.5	-0.4	-0.0	0.2	-0.7	0.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	4.1	2.0	-1.3	-0.9	-0.4	-1.2	-0.6
Whole body fat mass	0.2	0.7	3.0	-1.7	0.4	-0.1	0.6	-0.1	-0.8
Leg fat mass (right)	0.1	0.5	2.6	-1.6	0.6	0.4	0.0	0.3	0.1
Arm predicted mass (right)	0.3	1.5	2.6	-0.1	-1.1	-1.6	1.6	-1.2	-1.1
Pulse rate, automated reading	0.5	1.7	3.6	1.0	-1.8	-0.8	1.9	0.3	-1.4
Alcohol intake frequency.	1.1	2.6	6.5	-1.8	2.5	1.6	-1.4	-0.3	1.2
Comparative height size at age 10	2.9	16.2	34.7	-0.4	-3.0	-5.2	-0.4	-5.9	-5.2
Number of full sisters	0.3	0.3	1.1	1.1	-0.0	-0.1	0.6	-0.6	-0.3
Suffer from ‘nerves’	0.5	0.8	2.1	-1.1	0.4	0.7	1.5	0.4	-0.8
Overall health rating	1.0	2.2	3.9	-1.8	2.0	1.8	-1.2	0.4	0.8
Chest pain or discomfort	1.1	1.6	2.7	-1.6	0.8	1.4	1.0	1.6	-0.7
Had major operations	0.7	0.8	2.1	-0.3	-1.5	-0.9	0.7	-1.0	-0.3
Age at last live birth	0.4	0.7	2.8	1.7	-0.1	-0.2	0.6	-0.1	0.8
Family relationship satisfaction	1.3	1.6	4.1	-0.7	1.2	1.5	-0.7	0.8	2.0
Leg pain on walking	0.7	0.9	1.9	-1.4	-1.0	-1.2	0.5	-1.0	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.8	-0.0	1.0	1.3	0.8	0.8	-0.0
Commuting to job workplace: Car/motor vehicle	3.7	4.3	7.3	2.7	2.0	2.2	-1.5	2.0	1.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.9	-0.1	0.3	-0.8	-1.4	-1.2	0.6
Medication: Aspirin	0.9	1.1	4.8	-2.2	0.4	0.7	0.5	1.0	0.2
Supplements: Vitamin C	0.6	0.7	2.0	-1.4	-0.5	-0.6	1.1	-0.5	-0.5
Knee pain experienced in last month	1.3	2.0	7.5	-0.2	2.7	2.0	-0.1	0.5	0.3
Hypertension (Self-reported)	0.1	0.4	1.7	-1.3	-0.0	0.0	-0.0	-0.6	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.8	4.5	10.4	1.5	-1.5	-2.2	-0.7	-2.5	-3.2
Illnesses of father: Heart disease	0.3	0.4	0.9	1.0	-0.2	-0.4	0.8	0.4	0.8
Illnesses of siblings: Diabetes	0.2	0.2	0.7	0.0	-0.1	0.4	0.8	0.7	-0.2
Smoking status: Previous	1.1	1.6	2.8	0.9	-1.7	-1.6	-0.5	-1.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	2.9	6.1	13.2	-0.1	-3.1	-3.6	1.3	-2.0	-2.8
Whole body fat-free mass	0.3	1.6	2.8	-0.4	-0.9	-1.5	1.7	-1.2	-1.5
Leg fat-free mass (right)	0.3	1.6	4.8	-1.1	-0.4	-0.9	2.2	-0.4	-1.6
Arm fat percentage (left)	0.4	1.5	2.7	-1.6	1.6	1.4	0.5	1.1	0.1
Average weekly red wine intake	0.1	0.2	0.4	0.7	0.4	0.3	0.1	-0.5	-0.2
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.1	2.0	-1.5	-1.3	0.4	-1.1	-1.3
Mood swings	0.1	0.2	0.6	0.2	-0.8	0.0	0.1	-0.1	-0.6
Loneliness, isolation	0.5	0.7	1.2	-1.1	-1.1	-0.6	-0.5	-1.0	0.0
Long-standing illness, disability or infirmity	0.8	1.2	4.9	-2.2	-0.5	-0.5	0.7	-0.9	-0.6
Ever had bowel cancer screening	0.5	0.6	1.3	-0.3	-1.1	-0.7	-0.1	-0.5	-1.1
Diabetes diagnosed by doctor	0.2	0.3	1.0	-1.0	-0.2	-0.1	0.7	-0.1	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.2	0.4	-1.5	-1.3	-1.0	-1.3	-1.5
Friendships satisfaction	1.4	1.7	7.1	0.1	0.9	0.6	-1.4	-0.4	2.7
Qualifications: nursing, teaching	0.6	1.0	2.0	1.1	-1.4	-0.3	1.4	0.8	-0.2
Commuting to job workplace: Walk	1.0	1.1	5.9	-2.4	0.3	0.4	-0.1	-0.1	0.6
Eye problems/disorders: Cataract	1.1	1.3	3.4	1.0	1.8	1.8	-0.3	0.4	0.1
Mouth/teeth dental problems: Mouth ulcers	2.1	3.3	6.7	-1.2	2.6	2.5	0.6	1.8	1.4
Medication for cholesterol	0.7	1.1	1.9	0.5	-0.9	-1.2	-1.4	-1.0	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.8	-0.5	1.4	0.3	-1.3	-0.9	0.2
Back pain experienced in last month	1.2	1.7	6.0	-2.4	-0.6	-0.3	1.4	0.5	-1.2
Mineral and other dietary supplements	1.0	1.4	3.1	1.8	1.6	0.6	-1.1	0.5	0.8
Breast cancer (self-reported)	0.7	0.9	1.9	-0.1	1.3	1.4	0.2	0.9	0.8
Asthma (self-reported)	2.5	5.0	12.2	0.5	2.7	2.1	-3.5	-0.2	2.4
Osteoporosis (self-reported)	0.5	0.6	1.5	0.3	-0.1	-0.2	-1.2	-0.5	-1.2
Osteoarthritis (self-reported)	1.5	1.9	3.6	1.1	1.9	1.9	-1.2	0.4	1.3
Medication: Aspirin	1.4	1.8	8.2	-2.9	0.3	0.7	0.9	1.2	0.4
Medication: Gliclazide	1.0	1.2	4.8	-2.2	-0.6	0.1	1.0	-0.0	1.0
Illnesses of father: None of the above (group 1)	1.6	1.9	4.3	-0.2	-0.4	-1.2	-1.4	-2.1	-1.9
Smoking status: Current	1.1	1.8	3.3	-1.8	-1.6	-1.2	-1.1	-0.7	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.6	0.3	-1.0	-0.6	2.1	0.8	-0.2
Whole body water mass	0.3	1.6	2.7	-0.2	-0.9	-1.5	1.6	-1.3	-1.5
Leg predicted mass (right)	0.3	1.5	4.5	-1.0	-0.4	-0.9	2.1	-0.4	-1.5
Arm fat mass (left)	0.1	0.6	1.6	-1.2	1.0	0.6	0.5	0.4	-0.5
Number of self-reported non-cancer illnesses	0.3	0.5	1.4	0.9	0.2	0.1	-0.7	-0.4	-1.2
Average weekly champagne plus white wine intake	0.7	1.0	2.0	-1.4	-0.9	-0.7	-1.2	-0.3	1.0
Miserableness	0.2	0.3	0.7	0.1	-0.8	0.1	-0.8	0.3	-0.8
Guilty feelings	1.1	1.6	4.0	0.2	1.2	2.0	1.6	1.3	-0.1
Wears glasses or contact lenses	0.0	0.1	0.1	-0.3	0.3	0.1	-0.2	-0.3	-0.1
Ever taken oral contraceptive pill	1.9	2.1	5.4	0.0	1.3	1.6	0.3	1.6	2.3
Hearing aid user	1.9	2.1	9.4	-3.1	0.0	-0.0	1.5	1.0	0.3
Mother’s age at death	0.3	0.3	1.8	0.1	0.2	-0.4	0.0	-1.3	-0.0
Financial situation satisfaction	0.2	0.2	0.5	0.1	-0.4	-0.4	0.3	-0.6	-0.7
Tinnitus: Yes, now most or all of the time	2.9	3.4	12.9	-3.6	-0.8	-0.5	2.5	0.3	-0.7
Commuting to job workplace: Public transport	0.5	0.6	2.1	-0.8	1.4	0.4	0.3	-0.9	0.4
Eye problems/disorders: Glaucoma	1.8	2.2	4.1	-1.2	-2.0	-1.9	-0.2	-1.4	-1.4
Medication: Blood pressure	0.1	0.3	0.8	-0.9	0.1	0.4	0.6	-0.2	0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.0	-0.6	-0.1	-0.5	1.1	-0.2	-1.4
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.2	-1.4	-1.7	-0.5	2.0	0.2	-0.5
High cholesterol (Self-reported)	0.8	1.4	5.2	-0.3	0.1	-1.0	-1.2	-2.3	-0.9
Medication: Bendroflumethiazide	1.2	1.9	5.3	-2.3	-0.1	0.5	2.0	1.2	0.8
Medication: Paracetamol	0.4	0.6	1.3	-0.7	-1.1	-1.0	-0.7	-0.4	0.4
Medication: Lisinopril	0.5	0.6	2.9	-0.5	-0.3	-0.4	1.7	0.3	0.2
Medication: Atorvastatin	0.5	0.6	1.2	-0.6	-0.9	-1.1	-0.1	-0.8	-0.8
Illnesses of father: High blood pressure	0.6	0.7	1.6	0.1	0.9	1.3	0.1	1.3	0.6
Alcohol drinker status: Never	0.9	1.1	3.0	-1.7	1.0	0.8	0.1	0.4	1.3
Ever smoked	1.2	2.1	4.3	-0.5	-1.9	-1.4	-1.3	-0.9	-2.1
Basal metabolic rate	0.3	1.5	2.4	-0.6	-0.7	-1.4	1.6	-1.1	-1.5
Leg fat percentage (left)	0.2	0.8	1.5	-0.8	1.2	1.2	-0.2	0.7	0.7
Arm fat-free mass (left)	0.2	1.2	1.8	0.1	-0.8	-1.4	1.3	-1.3	-1.2
Number of operations (self-reported)	0.4	0.6	1.9	0.3	-0.6	-0.4	0.7	-0.9	-1.4
Average weekly beer plus cider intake	0.4	0.5	2.3	-0.1	-0.4	-0.4	-0.0	-0.7	-1.5
Irritability	0.4	0.7	1.5	-0.1	0.8	1.2	0.5	1.2	0.7
Risk taking	2.4	3.5	5.9	-0.7	-2.3	-2.4	0.5	-1.9	-2.4
Ever had prostate specific antigen (PSA) test	1.9	2.2	5.6	-2.4	-1.1	-0.3	2.0	1.4	0.4
Fractured/broken bones in last 5 years	0.4	0.5	1.6	-0.6	1.2	0.8	-0.6	0.1	0.1
Age started oral contraceptive pill	0.6	0.7	1.8	-0.1	-0.7	-0.7	-0.2	-1.2	-1.4
Diastolic blood pressure, automated reading	0.1	0.5	1.3	0.4	0.5	1.2	-0.3	0.8	0.4
Ever depressed for a whole week	0.4	0.5	1.9	-0.1	-0.1	0.6	0.5	0.6	1.4
Unable to work because of sickness or disability	2.0	2.6	4.5	-2.1	1.7	2.1	-0.6	1.8	0.1
Commuting to job workplace: Cycle	1.2	1.5	4.6	0.6	-1.1	-1.3	0.8	-0.6	-2.1
Myopia	0.6	0.9	3.5	0.4	1.0	0.9	-0.2	0.1	1.9
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.2	1.5	-0.5	-0.8	0.1	-0.5	-1.1
Cholesterol lowering medication	0.4	0.6	1.3	1.1	0.9	0.9	0.7	0.5	0.3
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.1	-1.3	1.5	1.8	0.3	1.2	0.7
Pain experienced in last month	1.3	2.2	4.4	0.8	-2.0	-1.9	-0.9	-2.1	-0.2
Supplements: Calcium	0.2	0.2	0.9	-0.3	-0.1	0.3	0.9	0.3	0.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.4	1.2	0.8	0.0	-0.9	-0.5	0.4
Heart attack/myocardial infarction (self-reported)	1.1	1.4	6.6	-2.6	-0.1	-0.0	1.1	0.6	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.9	-1.5	-0.4	-0.8	1.7	-0.1	-1.4
Heart disease (siblings)	0.1	0.1	0.4	0.6	-0.2	0.2	-0.6	0.2	0.2
Alcohol drinker status: Previous	1.0	1.2	2.1	-0.3	1.5	1.4	0.3	1.0	1.4
Pack years of smoking	1.4	2.0	4.2	-0.2	-1.8	-2.0	-0.9	-2.0	0.0
Impedance of whole body	1.1	5.4	9.6	-0.6	-2.1	-3.1	-1.1	-3.0	-2.8
Leg fat mass (left)	0.1	0.4	2.1	-1.4	0.6	0.4	0.0	0.1	-0.2
Arm predicted mass (left)	0.2	0.9	1.7	0.3	-0.5	-1.1	1.3	-1.1	-0.9