Hub : Genes

PPP4R2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.307	0.1138	9.9e-03	0.006	NA	0.034	NA	0.007	1.8e-01	NA	2.2e-02	NA	1.8e-01
2	GTEx	Brain Frontal Cortex BA9	0.316	0.1130	9.2e-03	-0.008	NA	0.003	NA	-0.009	6.2e-01	NA	2.5e-01	NA	6.4e-01
3	GTEx	Cells Transformed fibroblasts	0.184	0.0410	1.6e-09	0.190	NA	0.175	NA	0.186	3.5e-14	NA	4.2e-13	NA	5.9e-14
4	GTEx	Heart Left Ventricle	0.133	0.0481	3.2e-03	0.020	NA	0.001	NA	0.015	3.0e-02	NA	2.9e-01	NA	5.1e-02
5	GTEx	Muscle Skeletal	0.110	0.0310	3.0e-05	0.075	NA	0.106	NA	0.094	8.3e-08	NA	1.6e-10	NA	1.6e-09
6	ROSMAP	Brain Pre-frontal Cortex	0.155	0.0354	2.0e-11	0.104	0.094	0.113	0.09	0.124	3.2e-13	4.2e-12	2.5e-14	1.3e-11	1.2e-15

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	3.6	5.7	13.2	0.1	-0.6	-3.1	1.0	-3.6	-3.1
Bipolar Disorder or Schizophrenia	2.0	5.0	8.7	-0.3	-1.4	-3.0	1.7	-2.9	-2.8
Depressed Affect (Nagel 2018)	1.0	2.1	4.1	0.5	1.2	-1.5	1.4	-2.0	-1.7
Depression (Nagel 2018)	1.3	1.9	7.2	2.7	0.3	-0.7	1.5	-0.9	-0.6
Intelligence (Savage-Jansen 2018)	0.8	2.5	5.2	1.0	0.8	-1.7	-2.3	-2.1	-1.1
Neuroticism (Nagel 2018)	1.3	3.0	6.3	0.5	1.1	-1.6	2.1	-2.5	-1.7
Schizophrenia (2018)	0.6	1.2	1.8	-0.4	-1.3	-1.3	1.4	-0.8	-1.1
Schizophrenia vs Biploar Disorder	0.6	0.8	1.9	-0.9	0.4	1.0	0.3	1.4	0.8
Worry (Nagel 2018)	1.2	2.6	5.8	0.9	0.6	-1.5	2.1	-2.4	-1.4
Alzheimer’s Disease (in mother)	2.6	3.1	7.6	0.0	-0.0	-2.2	0.8	-2.8	-2.3
Alzheimer’s Disease (in father)	0.7	0.8	2.5	0.1	-0.7	0.2	1.3	1.6	0.3
Alzheimer’s Disease (including proxy)	1.3	1.8	3.4	-0.5	0.1	-1.8	1.0	-1.8	-1.8
Crohns Disease (2017)	0.1	0.3	0.7	-0.6	-0.7	-0.3	0.8	0.2	-0.2
Irritable Bowel Disease (IBD)	0.9	2.2	3.6	-0.7	-1.8	-1.9	0.7	-1.5	-1.9
Ulcerative Colitis (UC)	1.8	3.5	5.9	-0.8	-2.0	-2.3	0.4	-2.2	-2.4
Major Depression (MDD)	0.3	0.4	0.9	0.9	0.9	0.0	-0.7	0.6	0.2
Reaction Time	1.0	2.0	6.1	-1.2	-1.7	-0.4	2.5	-0.4	-1.1
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.4	0.8	0.3	-1.3	-1.8	-1.3	-0.8
Breast Cancer	0.1	0.3	0.5	0.6	-0.3	0.7	-0.6	0.3	0.6
Ovarian Cancer	0.2	0.2	1.3	0.0	-1.1	-0.1	0.0	0.2	0.0
Prostate Cancer	4.2	5.9	13.2	-2.2	-0.2	3.2	0.2	3.6	2.6
Age at First Birth	1.2	1.7	4.2	-0.2	-1.2	1.2	-2.0	1.5	0.9
Bipolar Disorder (2011)	0.9	0.9	2.2	0.1	-0.3	-1.5	-0.3	-1.3	-1.1
Body Mass Index (BMI) (2010)	1.3	1.8	3.9	0.4	-1.3	-1.9	0.2	-1.1	-2.0
Coronary Artery Disease (CAD)	0.8	0.9	2.4	0.4	-0.7	1.1	0.1	1.5	1.2
Crohns Disease (2012)	0.5	0.8	3.1	-1.0	-0.5	-0.5	1.8	-0.3	-0.6
Mean Putamen Volume	0.6	0.7	1.3	-0.8	1.1	-0.8	-0.2	-0.5	-1.1
Fasting Glucose	0.8	0.9	2.0	1.3	0.2	1.1	-0.2	1.4	0.7
HbA1C	0.3	0.3	1.0	0.0	-1.0	0.6	0.5	0.1	0.4
HDL Cholesterol	0.2	0.4	0.9	-0.8	0.9	0.2	-0.0	0.9	0.4
LDL Cholesterol	1.5	2.4	4.2	1.8	-0.6	2.0	-0.8	1.5	2.1
Lupus	0.6	0.9	4.9	0.3	0.5	0.3	-2.2	-0.2	0.3
Neuroticism (2016)	1.0	1.4	6.8	0.7	2.6	0.3	-0.7	0.3	0.4
Primary Biliary Cirrhosis	0.3	0.4	1.8	0.1	0.0	-0.2	1.3	0.5	-0.7
Rheumatoid Arthritis	0.5	0.7	1.4	-1.2	-0.5	-0.5	1.1	-0.8	-0.8
Schizophrenia (2014)	1.1	2.3	3.1	-1.2	-1.6	-1.6	1.8	-1.6	-1.4
Triglycerides	1.3	2.2	5.3	0.4	0.9	1.6	-2.3	1.4	1.6
Type 2 Diabetes (T2D) (2012)	1.6	1.9	3.7	0.8	0.7	1.8	0.8	1.6	1.9
Ulcerative Colitis	3.4	4.9	10.1	-0.1	-2.0	-2.9	1.0	-2.5	-3.2
Blood Eosinophil Count	0.1	0.4	1.3	0.3	-1.2	0.3	-0.2	1.0	0.0
Blood Platelet Count	0.0	0.3	0.8	-0.5	0.2	0.5	0.9	0.5	0.5
Blood Red Count	0.2	2.3	3.5	-1.8	1.1	1.4	-1.3	1.4	1.9
Blood White Count	0.4	3.3	6.8	-1.1	0.9	2.3	0.3	2.4	2.6
Heel T-Score	0.2	1.4	5.5	-0.8	-2.4	-0.0	1.2	0.9	-0.2
BMI	0.6	3.3	10.0	2.2	-1.6	-1.2	3.2	-0.6	-0.9
Height	1.3	24.3	57.0	0.3	-0.9	-7.1	1.5	-5.9	-7.5
Waist Hip Ratio (WHR)	0.6	2.5	4.7	0.1	0.3	-2.0	-1.4	-2.1	-2.2
Systolic Blood Pressure	1.2	6.1	13.9	0.4	0.4	3.4	0.2	3.3	3.7
Smoking Status	0.3	0.8	2.0	0.1	0.1	-1.2	0.4	-1.4	-1.1
Allergy or Eczema	0.9	2.4	4.4	1.7	-0.4	1.8	0.9	2.1	1.7
Cardiovascular Disease	0.5	1.6	2.6	0.7	1.0	1.5	1.3	1.6	1.4
Hypothyroidism (self reported)	0.3	0.6	1.6	0.7	1.0	0.4	-1.3	0.5	0.3
Respiratory disease	0.5	1.1	2.8	0.8	0.1	1.3	0.6	1.7	1.2
Type 2 Diabetes (T2D) (2018)	0.4	0.8	4.0	-0.6	0.6	0.1	2.0	0.4	0.2
Lung FEV1/FVC ratio	0.8	4.2	15.2	1.4	-1.9	-1.5	3.9	-1.0	-0.9
Lung FVC	0.6	3.1	6.3	-0.6	1.9	2.5	-0.9	1.5	2.3
Neuroticism	1.4	3.3	6.4	-0.3	1.3	-1.8	2.5	-2.3	-1.8
Chronotype (morning person)	0.1	0.3	0.6	-0.8	-0.4	-0.4	-0.5	0.6	-0.2
Hair Pigment	0.1	2.5	7.1	1.1	0.4	1.3	-1.0	1.9	2.7
Tanning	0.1	0.9	2.4	-1.5	0.9	0.3	-1.1	0.6	0.7
Hand grip strength (left)	0.2	0.5	1.3	0.2	-1.2	-0.5	-1.1	-0.5	-0.3
Number of treatments/medications taken	0.1	0.3	0.5	0.6	-0.1	0.6	-0.2	0.7	0.5
Average weekly spirits intake	0.8	1.0	3.1	-1.0	1.0	-0.2	-1.8	-0.7	0.4
Sensitivity / hurt feelings	0.8	1.4	1.9	-0.9	1.2	-1.4	0.9	-1.2	-1.3
Frequency of depressed mood in last 2 weeks	1.8	2.6	13.2	3.6	-0.5	-0.6	0.8	-0.6	-0.8
Hearing difficulty/problems: Yes	2.5	3.9	7.0	-0.9	-1.3	-2.6	0.6	-2.6	-2.5
Relative age of first facial hair	0.2	0.4	1.8	1.4	-0.6	0.1	-0.3	-0.4	-0.4
Other serious medical condition/disability diagnosed by doctor	4.8	6.3	13.7	0.1	-1.6	-3.7	0.8	-3.0	-3.4
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	-1.1	-0.2	-0.9	1.4	-0.4	-1.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.9	1.0	0.2	-0.4	-0.2	-0.4	-0.2
Systolic blood pressure, automated reading	1.0	2.9	6.2	-1.0	0.4	2.3	-0.4	2.2	2.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.2	0.8	-1.1	-0.4	0.9	0.2	-0.8
Angina	1.1	1.4	4.1	2.0	-1.6	-0.5	0.3	-0.4	-1.1
Medication for hormone replacement therapy	0.6	0.7	2.6	0.4	-0.5	0.2	1.6	0.9	-0.4
Vitamin and mineral supplements	0.2	0.3	1.1	0.5	1.1	-0.2	0.2	0.3	-0.5
Supplements: Zinc	0.6	0.6	1.6	-1.1	-0.7	0.0	-0.8	-1.3	0.0
Medication: Co-codamol	1.2	1.4	2.6	0.7	-0.5	-1.2	1.6	-1.4	-1.3
Medication: Metformin	0.3	0.4	0.8	-0.4	0.7	0.4	0.9	0.8	0.4
Diabetes (father)	0.4	0.5	1.5	-0.6	1.2	0.5	-0.5	0.5	0.4
Diabetes (mother)	2.8	3.5	6.8	-0.3	-0.8	-2.6	1.5	-2.2	-2.6
Severe depression (siblings)	1.9	2.2	5.3	0.1	-2.3	-1.6	0.7	-1.3	-1.7
Pack years adult smoking proportion	2.4	3.6	9.3	-1.1	0.5	-2.1	3.0	-1.7	-1.9
Impedance of leg (right)	0.3	1.4	2.5	0.8	1.4	1.4	-1.6	0.6	1.0
Leg fat-free mass (left)	1.3	6.6	12.8	1.4	-1.2	-3.6	1.9	-2.8	-3.5
Trunk fat percentage	0.5	1.9	3.1	-0.2	0.1	-1.7	1.4	-1.7	-1.7
Hand grip strength (right)	0.3	0.7	2.5	0.0	-1.3	0.1	-1.6	0.0	0.3
Townsend deprivation index at recruitment	4.6	6.5	10.4	-0.1	-2.3	-3.2	2.5	-2.6	-3.2
Current tobacco smoking	1.0	1.6	2.9	-0.1	-1.1	-1.6	1.2	-1.7	-1.4
Average weekly fortified wine intake	1.3	1.5	4.7	-0.0	0.0	1.5	0.3	2.2	1.5
Maternal smoking around birth	1.0	1.4	2.4	-1.2	1.2	1.3	0.2	1.3	1.6
Fed-up feelings	1.3	2.4	6.6	2.6	1.2	-0.1	2.5	-0.5	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	8.1	2.9	-0.9	-1.0	2.1	-1.1	-0.5
Relative age voice broke	0.3	0.4	1.7	0.8	-0.3	0.2	-1.3	0.0	-0.1
Taking other prescription medications	0.1	0.1	0.3	-0.1	-0.4	-0.5	0.5	-0.0	-0.5
Age when periods started (menarche)	0.1	0.2	1.0	1.0	0.1	0.2	0.6	0.0	0.1
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	6.0	1.0	0.8	0.2	-2.4	0.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	0.5	0.2	0.6	0.7	0.2	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.9	0.7	0.3	-0.2	1.0	-0.1	-0.0
Qualifications: CSEs or equivalent	0.9	1.1	4.9	0.7	2.2	0.0	-0.6	-1.0	0.5
Serious illness, injury or assault to yourself	1.2	1.4	2.0	1.3	-1.3	-1.3	0.9	-0.7	-1.4
High blood pressure	0.1	0.2	0.6	-0.8	-0.2	0.2	0.2	0.5	0.1
Hayfever, allergic rhinitis or eczema	0.8	1.7	5.7	2.4	-0.9	0.8	0.2	1.6	0.8
Multivitamins +/- minerals	0.2	0.2	0.7	0.5	-0.2	-0.5	0.1	-0.8	-0.3
Stomach or abdominal pain in last month	0.6	0.8	2.0	1.4	-0.1	0.6	1.1	0.6	0.8
Supplements: Glucosamine	0.5	0.6	1.3	-0.4	0.9	0.8	-1.2	0.2	0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.8	0.6	0.1	-0.1	0.9	-0.2	-0.2
Medication: Atenolol	0.2	0.2	0.4	0.4	-0.4	-0.4	0.6	-0.5	-0.6
Medication: Levothyroxine sodium	1.1	1.8	4.0	-0.5	1.5	1.0	-2.0	1.4	1.1
Sitting height	0.2	1.2	6.5	2.6	-0.2	-0.3	-0.5	0.3	-0.6
Chronic bronchitis/emphysema (father)	0.8	1.0	3.2	0.1	0.0	-1.1	0.0	-1.8	-1.2
High blood pressure (mother)	0.4	0.5	1.0	1.0	-0.8	-0.9	0.1	-0.5	-0.7
Body mass index (BMI)	0.4	1.9	7.0	0.1	-0.4	-1.4	2.6	-1.1	-1.0
Impedance of leg (left)	0.3	1.2	1.9	0.4	1.4	1.4	-1.2	0.8	1.2
Leg predicted mass (left)	1.3	6.7	13.1	1.4	-1.1	-3.6	1.9	-2.8	-3.5
Trunk fat mass	0.8	3.5	6.2	0.5	-0.3	-2.5	1.9	-2.3	-2.4
Waist circumference	0.9	3.3	6.2	0.4	-0.2	-2.5	1.8	-2.3	-2.3
Number of incorrect matches in round	0.7	1.1	2.1	-0.6	1.4	0.8	-1.5	-0.2	1.1
Past tobacco smoking	0.9	1.6	3.0	0.7	-0.8	1.6	0.7	1.5	1.7
Alcohol usually taken with meals	0.3	0.5	2.3	-0.5	-0.6	0.3	-1.5	0.3	0.4
Nervous feelings	0.1	0.2	0.8	0.1	0.6	0.3	0.9	-0.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.6	0.9	0.7	-0.4	1.3	-0.5	-0.7
Hearing difficulty/problems with background noise	4.9	7.8	17.6	-1.6	-0.8	-3.8	0.5	-3.3	-4.2
Hair/balding pattern: Pattern 2	0.8	1.1	3.8	1.9	0.3	-0.9	-0.1	-1.0	-0.9
Had menopause	1.4	1.7	2.8	-1.6	0.6	-1.5	1.1	-0.9	-1.7
Had other major operations	1.8	2.2	3.8	0.4	-1.9	-1.9	-0.7	-1.4	-1.8
Forced vital capacity (FVC)	0.1	0.3	0.7	0.9	0.7	-0.1	0.2	-0.2	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	2.6	0.1	-0.3	-0.3	1.6	-0.5	-0.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.7	0.2	-1.2	-1.1	0.2	-1.6	-0.8
Qualifications: None of the above	1.0	2.2	4.7	-1.4	0.3	2.2	1.0	1.4	1.8
Financial difficulties in last 2 years	0.8	1.0	2.0	0.7	-1.4	-0.8	0.9	-1.2	-0.9
Mouth/teeth dental problems	0.7	1.1	1.6	-1.0	1.1	0.9	-0.9	1.3	1.0
Heart attack	0.5	0.6	1.9	1.4	0.1	0.1	-1.1	-0.5	-0.0
Allergy	0.5	1.1	3.6	-1.9	0.6	-0.6	0.3	-1.4	-0.5
Pain all over the body in last month	0.8	0.9	3.6	0.2	1.9	-0.2	-0.7	-0.9	-0.4
Diabetes (self-reported)	0.7	1.1	5.5	-0.9	-0.3	-0.0	2.4	0.5	-0.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.7	1.6	-1.3	-0.9	-0.8	-0.2	-0.7
Medication: Ramipril	0.1	0.1	0.5	-0.7	0.3	0.1	0.4	0.2	-0.1
Medication: Simvastatin	1.7	2.5	4.7	0.1	2.2	2.0	-0.7	1.4	1.9
Fluid intelligence score	0.5	1.0	4.5	-0.5	1.1	-0.0	-2.1	-0.1	0.3
Illnesses of siblings	0.3	0.4	0.8	0.5	-0.4	-0.8	-0.1	-0.7	-0.9
Neuroticism score	1.3	2.8	6.0	1.5	1.0	-1.4	2.5	-1.8	-1.5
Weight	1.1	5.6	9.9	0.9	-0.8	-3.1	2.5	-2.6	-3.0
Impedance of arm (right)	0.3	1.3	1.9	-1.0	1.3	-0.7	-1.2	-1.4	-1.1
Arm fat percentage (right)	0.7	2.6	5.0	-0.4	0.1	-1.9	2.2	-2.0	-1.6
Trunk fat-free mass	1.3	7.5	13.7	2.0	-1.5	-3.7	2.2	-2.8	-3.6
Hip circumference	0.6	2.7	6.6	1.2	-0.2	-1.8	2.6	-1.4	-1.6
Time employed in main current job	0.9	1.1	3.2	-1.3	-1.8	0.1	1.3	-0.2	0.2
Alcohol intake versus 10 years previously	1.2	1.7	4.1	0.6	-2.0	-0.8	1.9	-0.8	-1.1
Father’s age at death	0.4	0.6	2.4	-0.5	-1.5	-0.1	0.6	-0.3	0.4
Worrier / anxious feelings	0.8	1.5	4.5	0.6	0.1	-1.0	2.1	-1.5	-1.0
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.2	12.5	3.5	-0.9	-1.9	1.6	-1.2	-2.1
Falls in the last year	3.4	4.7	9.4	-0.7	0.8	-3.0	-0.0	-3.1	-2.9
Hair/balding pattern: Pattern 3	0.3	0.4	1.7	-0.5	-0.6	-0.1	-1.3	-0.1	-0.2
Number of live births	0.4	0.6	1.8	-0.9	-1.4	-0.1	0.9	-0.0	-0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.8	1.3	-0.0	-0.7	0.9	-0.7	-1.0
Pulse rate	0.7	1.2	3.2	-1.0	0.6	-1.2	0.4	-1.8	-1.0
Happiness	2.7	3.2	9.4	2.1	-3.1	-1.5	0.9	-1.0	-1.1
Noisy workplace	0.4	0.5	1.5	0.9	-0.4	0.4	-1.2	0.4	0.0
Qualifications: A levels/AS levels or equivalent	1.7	3.8	8.9	1.7	-3.0	-2.1	-0.4	-1.4	-2.0
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	3.6	1.9	-0.0	-0.5	-1.2	-0.5	-0.6
Mouth/teeth dental problems: Dentures	1.2	2.0	5.5	0.7	0.2	-1.5	1.2	-2.3	-1.5
Asthma	0.4	0.8	2.1	0.3	0.1	1.1	0.6	1.5	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.4	1.8	1.1	0.5	0.9	0.4	0.4
Medication: Cholesterol lowering	0.7	1.1	1.7	-0.8	1.2	1.1	-1.3	0.0	1.3
Depression (self-reported)	1.4	1.7	5.0	2.0	-0.8	-0.4	2.2	-0.3	-0.3
Medication: Lansoprazole	0.1	0.1	0.1	-0.2	-0.3	0.0	0.3	-0.4	0.1
Prospective memory result	0.9	1.1	4.6	-2.1	-0.1	0.6	0.9	0.9	0.2
Lung cancer (father)	0.4	0.5	0.9	-0.8	0.8	-0.8	0.1	-0.3	-1.0
Illnesses of mother	2.1	2.6	6.2	0.3	1.0	1.5	-2.5	1.8	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.9	0.9	-0.0	-0.0	0.9	-0.0	-0.4
Pulse wave Arterial Stiffness index	1.6	1.9	7.2	1.3	-2.7	-0.9	1.0	-0.3	-0.7
Impedance of arm (left)	0.3	1.2	3.0	-1.2	1.4	0.1	-1.7	-0.8	-0.2
Arm fat mass (right)	0.8	3.3	5.7	0.3	-0.1	-2.4	2.0	-2.3	-2.1
Trunk predicted mass	1.3	7.2	13.1	2.0	-1.5	-3.6	2.1	-2.7	-3.5
Standing height	1.0	9.7	22.0	1.8	-0.9	-4.4	0.1	-3.7	-4.7
Length of working week for main job	1.1	1.2	2.9	-0.8	0.3	-1.6	0.2	-1.1	-1.7
Exposure to tobacco smoke at home	0.2	0.2	0.8	-0.3	-0.5	-0.1	0.9	0.2	0.2
Breastfed as a baby	0.8	1.0	2.0	-1.4	-0.8	-1.3	0.0	-0.9	-1.0
Tense / ‘highly strung’	1.8	2.9	6.0	0.6	-0.1	-1.8	2.5	-2.1	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	3.8	5.8	11.0	0.8	-1.6	-3.1	2.0	-2.7	-3.3
Hair/balding pattern: Pattern 4	1.0	2.5	5.6	-0.4	-0.3	2.4	-0.1	2.1	2.2
Birth weight of first child	0.3	0.5	1.7	0.1	0.3	0.8	1.3	0.5	0.6
Peak expiratory flow (PEF)	0.2	0.5	1.0	0.2	-1.0	-0.9	0.4	-0.7	-0.7
Pulse wave reflection index	2.2	2.7	5.2	1.6	-1.9	1.4	1.0	2.3	1.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.3	0.5	-0.3	0.7	-0.7	-0.3
Loud music exposure frequency	0.7	0.7	1.4	-0.5	0.1	-1.0	0.9	-1.0	-1.2
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.8	0.4	-0.6	-1.3	-0.5	-1.1	-1.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.6	1.6	-0.2	-0.6	-0.2	-0.8	-0.6
Blood clot in the leg (DVT)	1.6	2.1	4.8	-0.0	-0.4	-1.7	-1.7	-1.3	-2.2
Medication: Paracetamol	0.7	1.1	4.9	1.1	2.2	0.4	-0.7	-0.3	0.2
Headache pain in last month	0.9	1.5	2.1	1.4	1.3	-1.1	0.9	-1.4	-1.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.1	0.9	-0.5	-0.8	1.5	-0.3	-0.9
Glaucoma (self-reported)	0.4	0.4	0.8	0.7	-0.3	-0.9	0.5	-0.8	-0.6
Gout (self-reported)	2.2	3.0	7.6	-0.4	-0.9	-2.2	1.3	-2.8	-1.8
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.9	0.5	1.2	0.9	-0.8	1.4	0.9
Medication: Amlodipine	0.9	1.3	4.5	-0.1	-2.1	-1.0	0.4	-0.9	-1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	0.5	0.8	0.4	-1.0	0.3	0.6
Birth weight	1.2	2.7	4.8	1.2	-0.8	-1.8	1.4	-2.0	-2.2
Chronic bronchitis/emphysema (mother)	2.5	2.9	6.9	1.0	-0.8	2.1	-1.1	2.6	1.8
High blood pressure (siblings)	0.1	0.1	0.2	-0.5	0.4	0.1	0.0	-0.1	0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	0.5	0.7	0.4	0.7	-0.2	0.7	0.3
Body fat percentage	0.4	1.4	2.7	-0.1	0.2	-1.4	1.7	-1.5	-1.2
Leg fat percentage (right)	0.2	0.6	2.6	0.4	0.4	-0.4	1.6	-0.8	-0.2
Arm fat-free mass (right)	0.9	4.5	7.8	2.2	-1.0	-2.8	1.9	-1.9	-2.6
Exposure to tobacco smoke outside home	1.4	1.8	3.4	0.2	0.0	-1.7	1.3	-1.8	-1.7
Comparative body size at age 10	0.1	0.3	0.7	0.3	0.7	-0.8	-0.2	-0.6	-0.2
Number of full brothers	1.8	2.3	3.2	1.6	1.3	-1.8	1.8	-1.3	-1.2
Worry too long after embarrassment	1.0	1.8	7.6	0.3	-1.3	-0.5	2.8	-0.7	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.3	5.0	1.1	-1.6	-2.0	1.4	-2.2	-2.2
Wheeze or whistling in the chest in last year	1.3	2.2	4.7	1.9	-0.3	1.1	1.7	2.2	1.0
Number of children fathered	3.6	4.1	8.5	-1.2	1.6	2.5	0.3	2.9	2.4
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.5	-1.6	0.4	1.2	-1.0	1.1	1.4
Age at first live birth	0.0	0.1	0.2	-0.2	0.2	-0.0	-0.2	0.4	-0.3
Pulse wave peak to peak time	1.4	1.6	6.3	-1.3	2.5	0.6	-1.1	0.0	0.3
Health satisfaction	0.9	1.2	3.6	0.5	-1.9	-1.3	0.1	-1.0	-0.6
Shortness of breath walking on level ground	1.9	2.3	6.0	-0.1	-1.5	-1.8	-0.6	-2.5	-1.4
Qualifications: College or University degree	1.6	5.1	8.5	2.3	-2.4	-2.9	-0.6	-1.5	-2.9
Eye problems/disorders: None of the above	0.5	0.5	1.6	-1.3	1.0	0.3	-0.4	0.4	0.3
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.4	0.9	0.1	-0.9	1.0	-0.5	-1.2
Emphysema/chronic bronchitis	0.5	0.6	2.9	0.2	-0.4	-0.1	1.7	0.1	-0.5
Medication for pain relief, constipation, heartburn	0.7	1.3	2.7	-1.7	-1.0	-1.3	-0.8	-0.7	-1.0
Neck or shoulder pain in last month	2.0	2.9	5.3	2.0	-1.1	-1.6	0.9	-2.3	-1.8
Medication: Blood pressure	0.1	0.1	0.5	-0.3	-0.4	-0.1	-0.7	-0.1	-0.2
Angina (self-reported)	1.4	1.9	4.9	2.2	-1.6	-0.9	0.5	-0.7	-1.5
Migraine (self-reported)	0.1	0.1	0.4	-0.2	-0.6	-0.3	0.1	0.0	-0.5
Medication: Ibuprofen	0.4	0.4	1.5	1.2	0.8	0.3	0.1	0.5	0.1
Medication: Allopurinol	0.4	0.5	1.3	0.0	0.0	-0.9	0.6	-1.1	-0.8
Medication: Omeprazole	0.3	0.3	1.0	-0.0	0.5	0.8	0.1	1.0	0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.4	0.3	0.0	0.2	0.2	0.1
Mean time to correctly identify matches	0.9	1.8	6.3	-1.7	-1.2	0.4	2.5	0.2	0.0
Heart disease (mother)	0.7	0.8	2.6	1.0	-1.6	-0.3	1.1	0.0	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.7	-1.3	-0.8	0.9	0.8	0.6	0.7
Whole body fat mass	0.8	3.1	5.6	0.4	-0.1	-2.4	1.8	-2.2	-2.2
Leg fat mass (right)	0.5	1.9	3.5	0.6	0.1	-1.6	1.9	-1.8	-1.4
Arm predicted mass (right)	0.9	4.4	6.8	2.4	-1.1	-2.6	2.0	-1.7	-2.4
Pulse rate, automated reading	1.0	3.4	4.8	0.9	1.5	-2.2	2.0	-2.1	-2.0
Alcohol intake frequency.	1.4	3.1	4.8	0.8	-1.3	-1.8	2.0	-2.1	-2.2
Comparative height size at age 10	0.4	2.3	4.2	1.8	-0.3	-2.0	-0.5	-1.4	-2.0
Number of full sisters	0.2	0.2	0.6	-0.6	-0.3	0.2	0.8	0.1	-0.1
Suffer from ‘nerves’	0.8	1.2	3.1	0.1	0.4	-1.3	0.7	-1.8	-1.4
Overall health rating	0.6	1.3	2.7	1.6	-0.3	-0.9	1.2	-1.2	-1.2
Chest pain or discomfort	1.7	2.5	3.5	1.5	1.5	-1.4	1.9	-1.4	-1.7
Had major operations	5.2	6.1	12.6	-1.3	-0.4	-3.5	1.1	-3.0	-3.6
Age at last live birth	0.3	0.5	1.9	-1.4	-0.0	-0.4	-0.2	0.1	-0.9
Family relationship satisfaction	0.3	0.3	1.4	0.2	0.1	-0.7	0.1	-1.2	-0.4
Leg pain on walking	1.7	2.1	7.7	2.8	-0.8	-1.0	1.0	-1.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	6.0	-0.3	2.5	1.1	0.5	0.2	1.0
Commuting to job workplace: Car/motor vehicle	1.2	1.3	2.7	-0.3	0.7	1.6	-0.4	1.6	1.5
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	3.7	-1.9	1.3	0.9	-0.4	1.1	0.9
Medication: Aspirin	0.5	0.6	1.2	-0.2	-0.5	1.1	0.6	1.0	0.9
Supplements: Vitamin C	0.7	0.8	2.6	-0.7	-1.6	0.0	1.2	-0.6	-0.0
Knee pain experienced in last month	0.4	0.7	1.4	0.4	-1.0	-0.7	1.2	-0.7	-0.6
Hypertension (Self-reported)	0.1	0.3	0.6	-0.8	0.6	0.5	-0.5	0.7	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	3.5	-1.3	0.7	1.4	-0.5	1.3	1.9
Illnesses of father: Heart disease	0.8	1.2	2.4	0.2	1.6	1.1	0.7	0.7	1.6
Illnesses of siblings: Diabetes	0.8	1.0	4.9	0.2	-0.7	0.3	2.2	0.6	0.2
Smoking status: Previous	0.4	0.6	1.4	-0.5	1.2	-0.6	-0.9	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.7	1.6	0.7	-0.7	1.5	-0.5	-1.0
Whole body fat-free mass	1.3	7.5	14.0	1.9	-1.5	-3.7	2.2	-2.8	-3.6
Leg fat-free mass (right)	1.2	6.5	13.3	1.0	-1.3	-3.6	2.0	-2.7	-3.4
Arm fat percentage (left)	0.5	1.9	3.6	-0.3	0.1	-1.7	1.9	-1.8	-1.4
Average weekly red wine intake	0.2	0.4	2.0	0.1	-0.3	-0.2	-1.4	-0.1	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	0.5	-0.2	0.6	1.0	0.6	0.5
Mood swings	1.1	2.0	3.4	1.7	1.0	-1.4	0.9	-1.4	-1.8
Loneliness, isolation	0.6	0.8	2.0	0.6	1.4	-0.2	1.2	-1.0	-0.3
Long-standing illness, disability or infirmity	0.6	0.9	1.7	0.4	-1.1	-1.1	1.1	-0.4	-1.3
Ever had bowel cancer screening	0.7	0.9	3.7	-0.5	-0.3	0.6	1.9	0.0	0.8
Diabetes diagnosed by doctor	0.4	0.7	1.7	-1.2	0.7	0.2	1.3	0.7	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.0	0.3	1.0	0.2	0.6	0.4	0.2
Friendships satisfaction	1.4	1.8	3.0	1.5	-1.7	-1.7	0.3	-0.9	-1.2
Qualifications: nursing, teaching	2.4	3.7	8.4	1.7	-0.2	-2.9	0.2	-1.9	-2.7
Commuting to job workplace: Walk	0.7	0.7	1.2	0.5	-0.9	-1.1	0.4	-1.0	-0.9
Eye problems/disorders: Cataract	0.7	0.8	2.5	1.6	-1.4	-0.0	0.5	-0.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.4	1.0	-1.8	-1.5	0.0	-1.4	-1.8
Medication for cholesterol	0.2	0.3	1.0	0.7	-0.6	-0.4	-1.0	-0.3	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	3.0	-1.0	0.4	0.8	1.7	0.3	0.9
Back pain experienced in last month	1.4	2.1	4.0	1.5	0.6	-1.5	0.9	-2.0	-1.8
Mineral and other dietary supplements	1.3	1.8	5.2	2.3	-1.2	-0.1	1.9	0.8	0.2
Breast cancer (self-reported)	1.0	1.2	4.3	1.0	2.1	0.8	0.9	0.4	0.6
Asthma (self-reported)	0.4	0.8	2.0	0.2	0.1	1.0	0.6	1.4	1.1
Osteoporosis (self-reported)	0.0	0.0	0.2	-0.1	0.1	-0.2	-0.2	-0.4	-0.2
Osteoarthritis (self-reported)	0.9	1.1	2.2	0.2	-0.9	-1.2	1.2	-0.9	-1.5
Medication: Aspirin	0.8	1.0	1.7	0.1	-1.0	1.3	0.5	1.2	1.2
Medication: Gliclazide	0.9	1.1	2.6	-1.6	1.1	-0.1	1.5	0.6	-0.2
Illnesses of father: None of the above (group 1)	0.5	0.7	1.5	-1.0	-0.2	-1.0	-0.4	-0.4	-1.2
Smoking status: Current	0.7	1.2	2.4	0.0	-1.0	-1.3	1.0	-1.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	3.7	0.5	-0.0	0.5	1.9	-0.4	0.2
Whole body water mass	1.3	7.3	13.8	1.9	-1.4	-3.7	2.1	-2.7	-3.6
Leg predicted mass (right)	1.2	6.6	13.5	1.0	-1.2	-3.7	2.1	-2.7	-3.5
Arm fat mass (left)	0.7	2.9	5.0	0.6	-0.2	-2.1	2.2	-1.9	-1.9
Number of self-reported non-cancer illnesses	0.4	0.7	3.4	0.7	-1.8	-0.1	0.6	0.2	-0.1
Average weekly champagne plus white wine intake	0.5	0.7	1.8	-0.5	0.3	1.0	-1.4	0.7	0.9
Miserableness	1.1	1.9	4.5	0.7	-0.3	-1.8	1.2	-1.3	-2.1
Guilty feelings	0.6	0.9	1.7	1.3	0.5	1.1	0.0	1.1	1.0
Wears glasses or contact lenses	0.3	0.3	0.9	-0.9	-0.9	-0.1	0.2	0.2	-0.3
Ever taken oral contraceptive pill	0.6	0.7	3.4	1.8	-0.2	-0.5	-0.3	0.0	-0.5
Hearing aid user	2.5	2.8	4.6	-2.1	-1.1	-2.0	0.7	-1.8	-1.9
Mother’s age at death	0.8	1.0	2.5	0.3	-1.6	-1.1	0.0	-1.4	-0.6
Financial situation satisfaction	0.3	0.4	0.8	0.8	-0.8	0.4	-0.9	0.3	0.3
Tinnitus: Yes, now most or all of the time	1.1	1.2	1.9	0.2	-1.4	-1.3	1.0	-1.3	-1.1
Commuting to job workplace: Public transport	0.9	1.1	1.9	-0.8	-0.9	-1.4	-0.3	-1.3	-1.3
Eye problems/disorders: Glaucoma	0.4	0.5	1.5	0.9	-0.4	-0.0	1.2	0.3	0.4
Medication: Blood pressure	0.3	0.6	1.3	-1.1	-0.5	-0.7	0.7	-0.7	-0.6
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.0	-0.0
Supplements: Fish oil (including cod liver oil)	2.0	2.6	7.6	-2.8	1.4	1.2	-1.7	0.8	0.9
High cholesterol (Self-reported)	0.5	0.9	2.1	-0.8	1.5	0.8	-1.1	0.1	1.0
Medication: Bendroflumethiazide	0.4	0.7	1.5	-1.0	-1.2	-0.3	-1.0	-0.2	-0.3
Medication: Paracetamol	1.5	2.3	6.6	0.1	2.6	1.1	-2.1	0.7	1.1
Medication: Lisinopril	0.3	0.4	0.7	0.2	0.6	-0.7	-0.7	-0.8	-0.8
Medication: Atorvastatin	0.3	0.3	1.2	-0.5	-1.1	-0.2	-0.3	-0.7	0.3
Illnesses of father: High blood pressure	0.3	0.4	0.8	0.8	-0.6	0.4	-0.7	0.9	0.4
Alcohol drinker status: Never	2.9	3.5	5.7	0.8	-1.3	-2.4	1.7	-2.1	-2.4
Ever smoked	1.7	2.9	5.3	-1.5	-0.4	-2.1	-0.9	-2.2	-2.3
Basal metabolic rate	1.3	7.3	13.5	1.7	-1.3	-3.7	2.3	-2.8	-3.5
Leg fat percentage (left)	0.2	0.7	3.3	0.3	0.2	-0.6	1.8	-0.8	-0.2
Arm fat-free mass (left)	0.9	4.6	8.0	1.8	-1.2	-2.8	2.1	-1.8	-2.6
Number of operations (self-reported)	3.9	5.7	11.0	1.0	-1.7	-3.3	1.1	-2.8	-3.3
Average weekly beer plus cider intake	2.4	3.5	8.2	1.1	0.0	-2.4	0.8	-2.2	-2.9
Irritability	1.2	2.1	3.3	1.8	1.6	-1.1	1.1	-1.6	-1.4
Risk taking	0.6	0.9	3.8	0.7	-0.8	-0.6	2.0	-0.1	-0.3
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.4	-1.1	-1.6	-1.5	0.5	-1.2	-1.3
Fractured/broken bones in last 5 years	1.9	2.5	4.5	2.1	-0.8	-1.5	1.8	-0.9	-1.9
Age started oral contraceptive pill	0.7	0.9	2.0	-0.6	1.4	0.8	-1.4	0.6	0.5
Diastolic blood pressure, automated reading	0.6	1.7	3.5	0.7	0.8	1.5	0.3	1.8	1.9
Ever depressed for a whole week	0.2	0.2	0.8	0.1	-0.9	-0.0	-0.2	-0.5	0.1
Unable to work because of sickness or disability	2.2	2.9	6.1	1.1	-0.2	-2.2	-0.7	-2.5	-2.1
Commuting to job workplace: Cycle	1.1	1.3	2.2	-0.2	-1.0	-1.4	1.1	-1.1	-1.5
Myopia	1.0	1.5	3.1	1.5	0.1	-1.8	0.3	-0.8	-1.6
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.3	0.5	0.1	0.0	-0.0	-0.1	0.3
Cholesterol lowering medication	0.6	0.9	4.1	-0.7	2.0	0.7	0.3	0.1	0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.6	-0.1	0.3	0.9	1.1	1.3	0.6
Pain experienced in last month	1.1	1.9	5.6	-2.4	0.7	0.9	-0.2	1.7	1.2
Supplements: Calcium	0.5	0.5	1.0	-0.8	-0.4	-0.7	0.5	-1.0	-0.8
Basal cell carcinoma (self-reported)	0.2	0.3	0.9	1.0	-0.1	-0.5	0.7	-0.1	-0.0
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.9	1.4	0.2	-0.1	-1.2	-0.7	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	4.4	-0.2	-0.1	-1.6	-1.7	-1.4	-2.1
Heart disease (siblings)	0.3	0.4	1.1	-1.1	0.7	-0.1	0.4	-0.6	-0.2
Alcohol drinker status: Previous	0.4	0.5	0.7	0.4	-0.1	-0.8	0.7	-0.9	-0.9
Pack years of smoking	2.7	4.0	8.9	-1.4	0.1	-2.3	3.0	-1.9	-2.0
Impedance of whole body	0.2	1.1	3.2	-0.7	1.4	0.9	-1.8	0.0	0.6
Leg fat mass (left)	0.6	2.2	4.2	0.5	-0.2	-1.8	2.0	-1.8	-1.4
Arm predicted mass (left)	0.8	4.1	7.4	1.8	-0.7	-2.7	2.1	-1.8	-2.5