Best TWAS P=1.21e-22 · Best GWAS P=4.03e-31 conditioned to 0
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ST3GAL6 | 0.10 | 0.02 | bslmm | 396 | 0.04 | 8.3e-06 | 3.27 | 5.1 | 2.9e-07 | -0.05 | 0.66 | 0.30 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | DCBLD2 | 0.16 | 0.13 | lasso | 3 | 0.14 | 2.4e-11 | -6.74 | 5.9 | 4.4e-09 | 0.14 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | ST3GAL6-AS1 | 0.24 | 0.09 | lasso | 7 | 0.17 | 1.6e-13 | 5.16 | 5.3 | 9.8e-08 | 0.07 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Brain Frontal Cortex BA9 | DCBLD2 | 0.32 | 0.22 | lasso | 7 | 0.22 | 1.6e-06 | -3.47 | 5.3 | 8.8e-08 | 0.16 | 0.69 | 0.14 | FALSE |
| 5 | GTEx | Brain Frontal Cortex BA9 | ST3GAL6-AS1 | 0.52 | 0.32 | enet | 29 | 0.26 | 1.2e-07 | -3.87 | 5.3 | 1.3e-07 | 0.21 | 0.15 | 0.80 | TRUE |
| 6 | GTEx | Breast Mammary Tissue (Male) | ST3GAL6-AS1 | 0.10 | -0.01 | lasso | 4 | -0.01 | 5.5e-01 | -3.53 | 5.8 | 6.3e-09 | 0.12 | 0.04 | 0.20 | TRUE |
| 7 | GTEx | Cells Transformed fibroblasts | CPOX | 0.22 | 0.03 | lasso | 7 | 0.04 | 4.7e-04 | 4.81 | 5.6 | 2.2e-08 | 0.11 | 0.48 | 0.05 | TRUE |
| 8 | GTEx | Cells Transformed fibroblasts | COL8A1 | 0.19 | 0.01 | lasso | 8 | 0.05 | 1.7e-04 | 5.57 | -8.4 | 3.8e-17 | -0.30 | 0.82 | 0.16 | TRUE |
| 9 | GTEx | Esophagus Gastroesophageal Junction | DCBLD2 | 0.24 | 0.21 | lasso | 4 | 0.19 | 1.4e-07 | -6.65 | 6.3 | 2.4e-10 | 0.13 | 0.96 | 0.00 | FALSE |
| 10 | GTEx | Esophagus Mucosa | DCBLD2 | 0.11 | 0.12 | lasso | 4 | 0.11 | 1.5e-07 | 5.04 | 5.4 | 6.0e-08 | 0.22 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Esophagus Mucosa | ST3GAL6 | 0.21 | 0.14 | enet | 9 | 0.09 | 2.5e-06 | -3.87 | 6.1 | 1.3e-09 | 0.14 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Nerve Tibial | DCBLD2 | 0.14 | 0.05 | lasso | 5 | 0.03 | 1.7e-03 | 7.00 | 9.8 | 1.2e-22 | 0.28 | 0.16 | 0.44 | TRUE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | DCBLD2 | 0.25 | 0.25 | lasso | 5 | 0.24 | 1.4e-13 | 4.97 | 5.3 | 1.0e-07 | 0.21 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | ST3GAL6 | 0.07 | 0.04 | enet | 16 | 0.04 | 2.0e-04 | 5.09 | 7.1 | 1.7e-12 | 0.24 | 0.58 | 0.23 | FALSE |
| 15 | GTEx | Thyroid | DCBLD2 | 0.14 | 0.12 | lasso | 5 | 0.15 | 1.5e-11 | -6.74 | 7.4 | 1.1e-13 | 0.18 | 1.00 | 0.00 | TRUE |
| 16 | GTEx | Thyroid | ST3GAL6 | 0.07 | 0.02 | enet | 12 | 0.05 | 6.4e-05 | 6.43 | 6.4 | 1.6e-10 | 0.14 | 0.14 | 0.29 | FALSE |
| 17 | METSIM | Adipose | CPOX | 0.09 | 0.02 | blup | 456 | 0.05 | 6.4e-08 | -0.12 | -8.0 | 1.5e-15 | -0.05 | 0.59 | 0.40 | FALSE |
| 18 | METSIM | Adipose | ST3GAL6 | 0.05 | 0.00 | bslmm | 412 | 0.03 | 4.5e-05 | 5.37 | 6.8 | 8.8e-12 | 0.01 | 0.06 | 0.55 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | COL8A1 | 0.09 | 0.00 | enet | 11 | 0.03 | 1.2e-04 | 0.89 | 5.2 | 1.7e-07 | 0.22 | 0.02 | 0.75 | TRUE |
| 20 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | DCBLD2 | 0.07 | 0.06 | enet | 3 | 0.07 | 7.6e-04 | -5.93 | 6.2 | 5.3e-10 | 0.16 | 0.13 | 0.06 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DCBLD2 | 0.09 | 0.01 | enet | 16 | 0.04 | 9.6e-05 | 7.50 | 9.3 | 1.3e-20 | 0.23 | 0.06 | 0.73 | FALSE |