Best TWAS P=3.41e-14 · Best GWAS P=7.26e-27 conditioned to 3.14e-30
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | BOC | 0.17 | 0.03 | lasso | 5 | 0.04 | 3.4e-03 | -7.9 | -5.2 | 2.0e-07 | 0.02 | 0.20 | 0.03 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | WDR52 | 0.13 | 0.07 | enet | 20 | 0.07 | 2.1e-04 | -4.3 | 5.5 | 4.1e-08 | 0.01 | 0.67 | 0.02 | FALSE |
| 3 | GTEx | Artery Aorta | BOC | 0.22 | 0.15 | lasso | 7 | 0.14 | 5.5e-08 | 7.5 | 7.3 | 3.8e-13 | -0.02 | 0.22 | 0.77 | FALSE |
| 4 | GTEx | Brain Cerebellum | BOC | 0.41 | 0.08 | lasso | 7 | 0.23 | 2.5e-07 | -2.4 | -5.9 | 3.7e-09 | 0.01 | 0.23 | 0.07 | TRUE |
| 5 | GTEx | Brain Hippocampus | SIDT1 | 0.49 | 0.06 | enet | 41 | 0.38 | 7.1e-10 | 8.0 | -6.0 | 1.4e-09 | 0.02 | 0.11 | 0.07 | FALSE |
| 6 | GTEx | Testis | RP11-553L6.5 | 0.20 | 0.00 | lasso | 5 | 0.02 | 6.0e-02 | -5.2 | -5.3 | 1.1e-07 | 0.04 | 0.05 | 0.05 | TRUE |
| 7 | METSIM | Adipose | RP11-572M11.3 | 0.10 | 0.03 | lasso | 6 | 0.06 | 8.6e-10 | 10.3 | 7.6 | 3.4e-14 | -0.04 | 0.00 | 1.00 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BOC | 0.05 | 0.05 | enet | 16 | 0.06 | 5.3e-07 | -7.9 | -6.8 | 1.1e-11 | 0.02 | 0.01 | 0.99 | TRUE |