TWAS hub - WDR52

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0510	0.0240	7.6e-03	0.041	-0.001	0.015	0.001	0.023	8.1e-06	4.4e-01	4.8e-03	2.1e-01	7.5e-04
2	GTEx	Adipose Subcutaneous	0.0890	0.0280	2.1e-05	0.068	NA	0.083	NA	0.088	3.2e-06	NA	2.5e-07	NA	1.1e-07
3	GTEx	Adipose Visceral Omentum	0.1280	0.0480	6.5e-04	0.069	NA	0.068	NA	0.064	1.8e-04	NA	2.1e-04	NA	3.2e-04
4	GTEx	Adrenal Gland	0.2817	0.0823	8.4e-05	0.079	NA	0.079	NA	0.041	8.9e-04	NA	8.5e-04	NA	1.3e-02
5	GTEx	Artery Tibial	0.0676	0.0298	4.2e-03	0.076	NA	0.051	NA	0.072	1.5e-06	NA	7.7e-05	NA	2.8e-06
6	GTEx	Brain Frontal Cortex BA9	0.3661	0.1100	2.8e-03	-0.011	NA	-0.004	NA	0.009	8.6e-01	NA	4.2e-01	NA	1.8e-01
7	GTEx	Cells EBV-transformed lymphocytes	0.2240	0.0950	9.0e-03	-0.009	NA	-0.003	NA	-0.001	9.6e-01	NA	4.3e-01	NA	3.5e-01
8	GTEx	Cells Transformed fibroblasts	0.1320	0.0400	4.8e-06	0.005	NA	0.051	NA	0.031	1.3e-01	NA	1.1e-04	NA	2.2e-03
9	GTEx	Colon Transverse	0.2690	0.0810	1.5e-05	0.069	NA	0.116	NA	0.106	3.4e-04	NA	3.7e-06	NA	9.5e-06
10	GTEx	Esophagus Muscularis	0.0830	0.0390	7.0e-03	0.028	NA	0.028	NA	0.025	8.1e-03	NA	7.5e-03	NA	1.1e-02
11	GTEx	Nerve Tibial	0.1157	0.0384	1.1e-04	0.033	NA	0.012	NA	0.023	2.0e-03	NA	4.7e-02	NA	9.1e-03
12	GTEx	Ovary	0.2130	0.0730	9.3e-04	0.256	NA	0.165	NA	0.234	5.5e-07	NA	7.3e-05	NA	1.9e-06
13	GTEx	Skin Not Sun Exposed Suprapubic	0.1140	0.0390	2.6e-04	0.074	NA	0.102	NA	0.113	6.8e-05	NA	3.2e-06	NA	9.0e-07
14	GTEx	Skin Sun Exposed Lower leg	0.1180	0.0440	2.0e-04	0.064	NA	0.046	NA	0.045	5.3e-06	NA	1.0e-04	NA	1.3e-04
15	GTEx	Testis	0.4820	0.0890	1.9e-08	0.287	NA	0.225	NA	0.259	3.6e-13	NA	2.5e-10	NA	7.3e-12
16	GTEx	Thyroid	0.1120	0.0360	1.9e-05	0.064	NA	0.072	NA	0.094	1.3e-05	NA	3.5e-06	NA	1.2e-07
17	METSIM	Adipose	0.0728	0.0281	2.0e-05	0.014	0.035	0.026	0.034	0.020	2.7e-03	5.1e-06	6.4e-05	6.7e-06	4.4e-04
18	TCGA	Lung Adenocarcinoma	0.0475	0.0288	4.3e-04	0.020	0.018	0.017	NA	0.022	2.1e-03	3.0e-03	4.3e-03	NA	1.1e-03
19	TCGA	Lung Squamous Cell Carcinoma	0.0671	0.0279	2.9e-06	0.029	0.057	0.053	NA	0.046	2.9e-04	4.8e-07	1.0e-06	NA	5.5e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Prostate Cancer	17.5	24.6	46.9	4.1	5.2	5.2	3.3	5.2	0.9	5.6	5.1	5.4	5.5	5.9	6.8	5.7	5.7	2.4	5.7	4.7	4.7	3.5
Wears glasses or contact lenses	9.1	10.5	15.4	-3.2	-3.4	-3.9	-2.8	-3.8	-0.5	-3.1	-3.0	-3.5	-3.3	-3.7	-2.8	-3.8	-3.8	-1.7	-3.9	-2.5	-3.7	-3.1
Osteoarthritis (self-reported)	5.8	7.6	13.2	-2.7	-3.0	-1.9	-2.7	-3.1	0.4	-2.7	-2.9	-2.7	-2.7	-2.9	-1.6	-3.6	-2.9	-1.5	-3.1	-3.3	-3.2	-3.4
Birth weight	4.5	9.8	24.3	4.0	4.0	4.3	2.9	4.1	2.5	1.8	2.3	3.3	3.4	2.3	3.0	2.6	3.1	4.9	2.7	1.6	2.5	1.1
Medication: Atenolol	4.4	5.5	10.2	-2.5	-2.9	-3.1	-2.8	-2.7	-0.9	-2.3	-2.5	-1.7	-2.4	-1.4	-2.8	-2.0	-2.6	-3.2	-2.1	-0.8	-2.4	-1.6
Time employed in main current job	4.0	4.6	8.8	-2.4	-2.7	-1.7	-2.6	-2.5	-0.5	-2.1	-1.8	-3.0	-1.5	-2.4	-1.6	-2.1	-2.4	-2.2	-2.5	-1.9	-1.9	-1.4
Depression (Nagel 2018)	3.9	5.8	15.6	-3.9	-2.2	-2.7	-3.1	-2.2	-1.3	-1.4	-2.4	-2.5	-2.1	-2.0	-2.4	-2.1	-2.6	-2.0	-2.8	-1.9	-2.8	-2.1
Other serious medical condition/disability diagnosed by doctor	3.7	4.7	9.8	-2.9	-2.8	-1.9	-2.1	-2.3	-2.3	-1.6	-1.2	-1.8	-2.8	-1.2	-2.7	-1.6	-2.2	-3.1	-1.8	-0.9	-2.5	-1.9
Bilateral oophorectomy (both ovaries removed)	3.7	4.2	8.9	-3.0	-1.7	-1.5	-1.6	-1.8	0.6	-2.3	-2.3	-1.8	-2.6	-1.4	-1.0	-2.3	-2.3	-1.7	-2.1	-2.7	-2.8	-2.2
Diabetes diagnosed by doctor	3.6	5.9	13.0	-3.2	-3.6	-2.0	-2.4	-3.0	-1.3	-1.8	-1.1	-1.8	-3.0	-2.1	-2.3	-2.0	-2.5	-3.5	-2.4	-1.4	-2.8	-2.3
Fractured/broken bones in last 5 years	3.6	4.6	13.9	3.3	2.7	2.9	2.3	3.0	2.1	1.0	0.7	1.7	1.5	1.2	1.1	1.5	2.6	3.7	2.0	0.9	2.2	0.8
Diabetes (self-reported)	3.5	5.4	9.2	-2.9	-3.0	-2.1	-3.0	-2.6	-0.8	-1.7	-1.7	-2.1	-2.9	-2.1	-2.1	-2.1	-2.4	-2.9	-2.3	-1.4	-2.5	-2.2
Neuroticism (2016)	3.4	4.9	8.6	-1.9	-1.6	-2.5	-1.2	-1.9	0.2	-2.5	-2.9	-2.4	-2.1	-2.8	-1.8	-2.6	-2.9	-1.0	-2.7	-2.5	-2.2	-2.2
Illnesses of siblings: Diabetes	3.4	4.2	7.1	-2.4	-2.5	-2.7	-0.9	-2.6	-0.8	-1.7	-2.2	-1.9	-2.3	-1.5	-2.1	-1.9	-2.7	-2.6	-2.0	-1.4	-2.1	-1.2
Mouth/teeth dental problems: Loose teeth	3.3	3.9	5.7	-1.8	-1.8	-2.1	-1.7	-1.9	0.5	-1.8	-2.3	-2.2	-2.3	-2.1	-2.1	-2.2	-2.4	-1.1	-2.3	-1.4	-2.4	-2.2
Waist Hip Ratio (WHR)	3.2	14.4	25.5	-3.3	-3.7	-3.5	-3.6	-3.9	-0.2	-4.2	-3.3	-4.7	-4.0	-4.7	-5.0	-4.2	-4.4	-2.3	-4.3	-3.6	-3.5	-2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.2	3.8	8.3	-2.1	-2.2	-2.0	-1.5	-2.1	-1.8	-1.2	-1.7	-1.3	-2.2	-1.5	-2.9	-1.8	-2.5	-2.1	-2.2	-1.3	-2.2	-1.6
Number of self-reported non-cancer illnesses	3.2	5.6	12.0	-2.6	-2.6	-2.2	-3.5	-2.7	-1.7	-2.1	-1.9	-2.0	-2.9	-2.0	-2.4	-2.5	-2.5	-2.5	-2.3	-1.7	-2.4	-1.9
Frequency of depressed mood in last 2 weeks	3.1	4.3	8.5	-2.9	-2.2	-2.1	-2.1	-1.9	-1.1	-1.0	-1.9	-1.9	-1.7	-1.8	-1.8	-1.8	-2.5	-2.4	-2.4	-2.1	-2.5	-2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	3.1	4.0	10.7	-1.3	-1.7	-2.2	-1.8	-1.9	0.3	-2.2	-2.7	-3.3	-0.9	-2.4	-1.4	-2.2	-2.5	-0.9	-2.2	-2.2	-1.7	-1.5
Pain type(s) experienced in last month: Hip pain	3.0	3.8	6.7	-1.8	-2.1	-1.7	-2.6	-1.8	-0.6	-2.0	-1.9	-1.9	-2.0	-1.9	-1.9	-2.1	-1.6	-1.7	-2.1	-2.1	-2.2	-2.2
Loneliness, isolation	2.9	4.0	11.0	-3.3	-2.1	-1.3	-1.6	-1.6	-0.9	-1.8	-1.6	-1.4	-2.4	-1.0	-1.4	-1.5	-2.4	-2.9	-1.8	-2.0	-2.6	-2.3
Medication: Ramipril	2.7	3.5	5.8	-2.0	-2.2	-2.0	-2.0	-2.4	-0.6	-1.8	-1.1	-1.6	-2.0	-1.8	-2.1	-1.9	-2.0	-2.4	-2.0	-1.9	-1.7	-1.4
Cholesterol lowering medication	2.7	4.0	7.2	-2.5	-2.0	-1.0	-2.7	-1.9	-0.1	-2.1	-1.5	-2.3	-2.6	-1.6	-2.2	-2.2	-2.1	-1.8	-1.8	-2.0	-2.2	-1.6
Type 2 Diabetes (T2D) (2018)	2.6	4.8	12.0	-3.5	-3.0	-1.6	-1.4	-2.6	-1.3	-1.3	-0.9	-1.6	-3.1	-1.3	-2.2	-1.6	-2.1	-3.4	-2.1	-1.5	-2.7	-2.0
Medication: Co-codamol	2.6	3.0	5.8	2.4	1.9	1.3	0.5	1.9	0.9	1.8	0.6	1.4	2.1	1.0	2.3	1.4	1.9	2.3	1.8	1.3	2.4	2.0
Fed-up feelings	2.6	4.6	8.1	-2.4	-2.4	-2.8	-1.6	-2.3	-2.1	-2.2	-2.1	-2.0	-1.7	-2.0	-2.2	-2.5	-2.3	-1.7	-2.1	-2.2	-2.2	-1.8
High blood pressure	2.6	7.4	10.6	-3.0	-3.0	-2.2	-3.0	-3.1	-0.1	-2.3	-2.5	-2.5	-2.7	-2.8	-3.3	-3.1	-3.0	-2.4	-3.0	-2.8	-2.8	-2.3
Mood swings	2.6	4.7	9.9	-3.1	-2.6	-3.1	-1.7	-2.8	-0.7	-1.4	-1.2	-1.5	-2.2	-1.7	-3.1	-2.1	-2.6	-2.5	-2.2	-0.7	-2.3	-1.2
Medication: Metformin	2.5	3.6	7.0	-2.6	-2.5	-1.5	-2.5	-1.7	-1.4	-1.5	-2.0	-1.9	-2.2	-1.3	-1.4	-1.2	-1.8	-2.6	-1.6	-1.0	-2.0	-1.9
Mother’s age at death	2.5	3.1	8.8	-0.5	-1.6	-0.5	-1.0	-1.4	3.0	-2.5	-2.1	-1.2	-1.8	-2.1	-0.4	-2.3	-1.2	0.1	-1.9	-1.8	-2.0	-2.6
Pulse wave peak to peak time	2.4	2.8	10.8	3.3	2.0	1.2	1.7	2.6	1.2	0.1	0.0	1.3	1.6	0.6	2.4	1.3	1.8	2.4	1.3	1.1	1.5	-0.2
Ever depressed for a whole week	2.4	3.0	4.9	-1.9	-2.2	-1.1	-1.7	-1.7	0.1	-2.0	-1.8	-1.4	-2.2	-1.6	-1.1	-2.0	-2.1	-1.7	-1.5	-1.7	-2.0	-1.6
Mineral and other dietary supplements	2.3	3.1	9.2	-1.3	-1.4	-1.2	-1.6	-1.2	0.4	-1.8	-2.0	-1.1	-2.1	-2.0	-1.4	-1.8	-2.1	0.1	-2.3	-1.4	-2.4	-3.0
Unable to work because of sickness or disability	2.3	3.0	6.0	-1.3	-1.5	-0.7	-1.3	-1.4	-1.5	-1.7	-2.3	-1.3	-2.0	-2.0	-1.4	-1.8	-2.1	-0.9	-2.2	-2.4	-1.8	-2.0
Commuting to job workplace: Car/motor vehicle	2.2	2.6	6.9	-0.6	-1.3	-2.5	-1.6	-1.6	-0.0	-1.9	-2.6	-2.1	-1.4	-2.0	-2.0	-1.6	-1.6	-1.1	-1.5	-1.1	-0.5	0.2
Risk taking	2.2	3.2	8.4	-2.8	-1.8	-0.6	-1.9	-1.5	0.4	-0.9	-0.5	-1.7	-1.9	-0.9	-1.0	-1.8	-1.5	-1.8	-1.9	-2.5	-2.6	-2.9
Depressed Affect (Nagel 2018)	2.1	4.4	9.8	-3.1	-2.1	-2.3	-2.4	-2.1	-0.9	-2.0	-2.3	-2.1	-2.2	-1.6	-2.4	-2.1	-2.1	-2.2	-2.0	-1.4	-2.3	-1.4
Lung FEV1/FVC ratio	2.1	10.7	24.0	-3.8	-4.0	-2.6	-3.7	-3.7	-2.1	-2.6	-1.3	-2.2	-4.2	-2.4	-2.8	-3.1	-3.4	-4.9	-3.3	-2.7	-3.9	-3.4
Angina	2.1	2.7	9.3	-2.2	-2.3	-1.6	-1.0	-2.1	-3.1	-0.7	-0.5	-0.2	-1.4	-0.8	-1.7	-1.2	-1.6	-2.9	-1.2	-1.2	-1.5	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	6.4	-1.3	-1.6	-2.5	-1.7	-1.7	-0.5	-1.6	-2.1	-2.1	-0.9	-1.8	-2.5	-2.0	-2.3	-0.8	-1.6	-2.5	-1.4	-0.9
Angina (self-reported)	2.1	2.8	8.5	-2.3	-2.4	-1.6	-0.9	-2.2	-2.8	-0.8	-0.6	-0.4	-1.6	-0.8	-1.9	-1.2	-1.7	-2.9	-1.2	-1.1	-1.5	-0.8
Hypertension (Self-reported)	2.1	5.9	8.9	-3.0	-2.7	-1.6	-2.9	-2.7	-0.3	-2.0	-2.1	-2.1	-2.6	-2.3	-2.7	-2.7	-2.8	-2.5	-2.7	-2.5	-2.7	-2.2
Medication: Aspirin	2.1	2.7	5.9	-1.5	-1.7	-1.9	-1.5	-2.2	-0.8	-1.0	-1.5	-0.7	-1.4	-1.7	-2.4	-2.1	-1.8	-1.1	-2.1	-1.4	-1.7	-1.6
Miserableness	2.1	3.7	7.3	-2.4	-2.3	-2.7	-2.3	-2.3	-1.1	-1.3	-1.3	-2.1	-2.0	-1.6	-2.4	-1.9	-1.9	-2.0	-1.8	-0.7	-1.9	-1.2
Number of incorrect matches in round	2.0	3.4	12.0	-0.6	-1.3	-1.8	-1.3	-1.4	-0.8	-2.4	-3.5	-1.9	-1.4	-2.6	-1.6	-2.3	-2.1	0.4	-2.3	-1.8	-1.4	-1.3
Past tobacco smoking	2.0	3.7	8.3	2.9	2.1	1.1	1.7	2.2	-1.2	1.6	1.2	1.6	2.4	1.1	1.6	2.0	2.4	2.4	1.9	0.9	2.8	2.0
Tense / ‘highly strung’	2.0	3.3	9.1	-0.8	-1.2	-1.9	-1.1	-1.2	1.3	-2.5	-3.0	-2.0	-1.5	-2.2	-0.8	-2.3	-1.1	-0.1	-1.7	-3.0	-1.6	-2.0
Pulse wave reflection index	2.0	2.4	7.2	-2.6	-1.8	-0.8	-2.2	-1.9	-0.6	-1.0	-0.7	-0.5	-2.2	-0.2	-1.7	-1.4	-1.4	-2.7	-0.9	-1.5	-1.6	-0.7
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	7.5	-2.7	-2.1	-1.8	-0.0	-1.8	-0.8	-0.9	-0.2	-1.0	-1.7	-0.5	-2.6	-1.4	-1.7	-2.5	-1.3	-1.2	-1.8	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	3.9	-1.3	-1.6	-1.8	-1.3	-1.6	0.8	-1.9	-1.5	-1.5	-1.6	-1.5	-0.7	-1.9	-1.3	-1.3	-1.7	-1.7	-2.0	-1.7
Ever had bowel cancer screening	2.0	2.3	8.6	-1.2	-1.6	-2.2	-1.8	-1.9	-0.7	-1.1	0.5	-1.6	-1.4	-1.4	-2.9	-1.4	-1.5	-1.6	-1.2	-1.4	-0.8	0.2
Commuting to job workplace: Cycle	2.0	2.4	9.3	0.3	1.0	1.5	1.4	1.1	-0.1	2.3	3.0	1.2	1.2	2.1	1.0	2.2	1.1	0.2	1.7	1.7	1.2	1.5
Cardiovascular Disease	1.9	6.2	10.3	-3.2	-3.1	-1.5	-2.3	-3.1	-1.3	-2.1	-1.3	-2.4	-2.8	-2.3	-3.1	-2.7	-3.2	-2.7	-2.6	-2.1	-2.5	-1.7
Illnesses of siblings	1.9	2.6	6.2	1.4	1.2	1.6	1.7	1.3	-1.5	1.9	2.5	1.9	1.5	1.6	2.1	2.0	1.3	0.4	1.6	1.2	1.5	1.3
Length of working week for main job	1.9	2.1	4.7	-2.2	-1.7	-1.0	-1.2	-1.6	-0.1	-0.8	-0.5	-1.6	-1.8	-1.2	-0.6	-1.5	-1.4	-1.8	-1.8	-1.3	-1.9	-1.9
Tinnitus: Yes, now most or all of the time	1.9	2.2	6.0	1.5	1.1	1.1	0.9	1.0	0.7	2.0	1.1	1.5	1.5	1.4	0.7	1.8	1.7	0.2	1.6	1.7	2.1	2.4
Medication: Atorvastatin	1.9	2.3	3.7	-1.4	-1.6	-1.6	-0.3	-1.7	-1.1	-1.7	-1.8	-1.8	-1.3	-1.7	-1.1	-1.8	-1.9	-1.2	-1.7	-1.4	-1.5	-1.6
Vascular/heart problems diagnosed by doctor	1.9	5.3	8.8	2.9	2.5	1.9	2.3	2.7	0.8	1.8	2.0	1.6	2.4	2.2	3.0	2.6	2.7	2.1	2.5	2.2	2.5	1.9
Neuroticism (Nagel 2018)	1.8	4.1	9.0	-2.1	-1.7	-2.5	-1.5	-1.7	0.4	-2.6	-3.0	-2.5	-1.8	-2.2	-2.0	-2.4	-2.0	-1.0	-2.1	-2.0	-2.0	-1.7
Pulse wave Arterial Stiffness index	1.8	2.1	8.0	-2.8	-1.6	-0.9	-1.8	-2.2	-0.9	0.1	0.1	-1.2	-1.2	-0.6	-2.2	-1.1	-1.6	-1.9	-1.1	-0.9	-1.1	0.5
Medication for pain relief, constipation, heartburn	1.8	3.0	7.9	1.0	1.9	1.9	1.3	2.3	1.1	1.5	1.9	1.6	1.2	2.2	2.8	2.1	1.7	1.2	2.0	1.4	1.5	1.0
Medication: Aspirin	1.8	2.4	4.5	-1.1	-1.6	-1.8	-1.1	-2.0	-0.7	-1.2	-1.9	-0.9	-1.1	-1.9	-2.1	-2.0	-1.6	-0.8	-2.0	-1.2	-1.6	-1.6
Medication: Blood pressure	1.8	3.4	5.9	-2.0	-1.6	-0.7	-2.0	-1.8	0.1	-2.1	-1.5	-2.0	-1.9	-1.6	-2.4	-2.1	-2.3	-1.8	-1.9	-2.0	-2.0	-1.6
Ever highly irritable/argumentative for 2 days	1.7	2.1	5.2	-1.9	-1.6	-1.4	-2.1	-1.7	-1.6	0.4	0.2	-2.0	-1.3	-0.8	-2.3	-0.6	-1.5	-2.2	-1.3	-0.1	-1.0	-0.3
Medication: Paracetamol	1.7	2.6	5.0	-1.4	-1.9	-2.2	-1.2	-2.2	-0.3	-1.7	-1.6	-2.0	-1.2	-1.8	-2.0	-1.8	-1.3	-1.7	-1.5	-1.6	-1.2	-0.4
Irritability	1.7	2.9	8.2	-2.9	-1.8	-2.3	-1.3	-1.5	-0.4	-1.5	-1.4	-2.0	-1.9	-0.7	-1.4	-1.8	-1.1	-1.6	-1.7	-0.5	-2.5	-2.2
Ulcerative Colitis	1.6	2.4	4.7	1.4	2.0	0.6	0.9	1.7	0.9	2.0	1.9	2.2	1.8	1.7	0.7	1.6	1.4	1.0	1.5	1.8	1.5	1.5
Ever used hormone-replacement therapy (HRT)	1.6	2.0	3.5	-1.8	-1.3	-1.2	-1.8	-1.7	0.7	-1.6	-1.0	-1.6	-1.6	-1.1	-1.6	-1.9	-1.4	-1.0	-1.3	-1.0	-1.8	-0.9
Alcohol usually taken with meals	1.6	2.6	5.4	-0.6	-1.6	-2.0	-0.5	-1.2	-0.6	-1.9	-2.1	-2.2	-0.8	-2.1	-1.0	-1.7	-2.0	-0.0	-1.8	-2.3	-1.6	-1.9
Ever taken oral contraceptive pill	1.6	1.8	6.4	1.1	0.5	0.9	0.2	1.1	-0.7	1.4	0.7	0.6	1.8	1.8	0.4	1.8	1.8	0.1	1.9	2.5	1.7	1.6
Alcohol drinker status: Previous	1.6	1.9	5.4	-1.7	-1.2	-1.7	-0.8	-1.4	-1.2	-0.7	-0.5	-2.3	-1.1	-1.7	-1.4	-1.2	-1.9	-0.6	-1.7	-1.1	-1.1	-1.1
Body Mass Index (BMI) (2010)	1.5	2.1	6.0	1.2	1.7	2.5	0.3	1.9	0.4	1.4	1.1	1.2	1.6	1.6	2.3	1.4	1.5	1.3	1.5	0.4	1.4	0.4
Lupus	1.5	2.3	6.9	-1.6	-1.2	-1.9	-1.6	-1.6	-0.9	-1.0	-0.7	-1.9	-2.0	-1.6	-2.6	-1.3	-1.8	-1.8	-1.5	-1.0	-0.8	0.3
Number of treatments/medications taken	1.5	2.8	6.2	-1.4	-1.6	-2.0	-1.2	-2.0	-0.7	-1.6	-2.5	-1.7	-0.9	-2.0	-2.2	-2.0	-1.5	-1.3	-1.7	-2.0	-1.4	-0.9
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	5.1	-2.3	-1.4	-1.4	-1.1	-1.5	-0.2	-1.0	-1.5	-1.0	-1.7	-1.3	-1.9	-1.6	-1.8	-1.2	-1.9	-1.4	-2.1	-1.9
Number of operations (self-reported)	1.5	2.2	7.5	-1.3	-1.5	-0.9	-2.7	-1.4	0.5	-1.3	-1.1	-2.0	-1.4	-1.5	-1.2	-1.3	-1.8	-2.0	-1.5	-0.5	-1.3	-1.2
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.5	-1.7	-1.3	-1.7	-1.2	-1.7	-1.5	-1.1	-1.2	-0.2	-1.8	-0.8	-1.1	-1.3	-1.5	-1.8	-1.5	-0.0	-1.9	-1.3
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	5.7	-1.8	-1.0	-2.2	-1.2	-1.4	-0.2	-0.8	-2.0	-2.4	-1.2	-1.7	-2.0	-1.4	-1.4	-0.4	-1.7	-1.3	-1.3	-0.9
Heart attack	1.4	1.8	3.5	-1.8	-1.3	-1.7	-1.2	-1.7	-1.6	-1.0	-1.2	-0.3	-1.8	-0.7	-1.1	-1.3	-1.5	-1.7	-1.4	0.1	-1.9	-1.3
Medication: Cholesterol lowering	1.4	2.2	5.3	-1.6	-1.7	-2.3	-1.0	-2.2	-0.4	-0.9	-1.1	-0.9	-1.0	-1.3	-1.7	-1.6	-1.5	-2.3	-1.6	-1.5	-1.2	-0.6
Lung cancer (father)	1.4	1.7	6.0	0.9	1.4	2.2	-0.3	1.4	-0.4	1.1	1.1	1.4	1.6	1.3	2.5	1.2	0.6	1.0	1.4	1.3	0.9	0.4
Number of children fathered	1.4	1.6	5.4	-1.9	-1.4	-1.9	-0.3	-1.7	-2.3	0.4	0.4	-0.9	-0.7	-0.9	-1.7	-1.0	-1.4	-0.8	-1.4	0.4	-1.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	5.7	1.9	2.1	0.8	0.8	2.3	-0.5	2.0	1.6	0.7	1.3	1.6	0.6	2.4	1.0	1.6	2.1	2.2	2.2	2.0
Alcohol drinker status: Never	1.4	1.7	6.6	0.9	1.6	2.5	-0.1	1.9	-1.6	0.6	0.7	1.1	0.7	1.1	2.6	1.1	1.1	1.2	1.1	0.4	0.7	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	4.8	-1.5	-1.5	-1.8	-1.4	-1.9	-1.0	-0.1	-1.0	-0.4	-1.2	-0.8	-2.2	-1.2	-1.6	-1.5	-1.3	-0.5	-1.4	-0.9
Heart disease (siblings)	1.4	1.7	6.0	-1.3	-1.4	-1.6	-1.8	-1.4	-0.4	-1.0	-1.2	-0.7	-1.3	-1.3	-2.4	-1.4	-1.5	-1.0	-1.3	-1.0	-1.0	-0.5
Verbal and Numeric Reasoning (VNR)	1.3	3.1	10.0	0.1	1.1	1.1	1.1	1.0	0.4	3.2	2.9	1.4	2.0	2.4	1.2	2.3	1.8	-0.7	1.9	1.3	1.8	2.2
Crohns Disease (2012)	1.3	2.1	5.7	1.3	2.1	2.1	2.3	2.1	1.6	-0.1	0.2	1.4	0.1	1.0	2.0	0.5	1.3	2.4	1.1	0.3	0.4	-0.4
Chronic bronchitis/emphysema (father)	1.3	1.5	7.6	1.8	1.4	1.7	0.2	1.1	2.8	-0.0	-0.1	0.7	0.9	0.4	2.2	0.3	1.2	0.7	1.0	-0.2	1.1	0.6
Nervous feelings	1.3	2.4	8.6	-0.4	-0.8	-2.0	-0.2	-0.9	0.1	-1.9	-2.9	-1.6	-0.9	-2.2	-1.3	-1.9	-1.6	0.5	-1.7	-2.4	-1.1	-1.5
Had menopause	1.3	1.6	3.1	-0.7	-0.6	-0.5	-0.9	-0.7	1.3	-1.7	-1.4	-1.6	-1.2	-1.6	-0.8	-1.5	-1.6	0.5	-1.6	-1.1	-1.4	-1.8
Financial difficulties in last 2 years	1.3	1.8	4.6	-0.1	1.5	2.1	1.8	1.4	-0.9	1.6	1.2	1.5	1.0	2.1	1.1	1.5	1.6	-0.1	1.6	0.6	0.5	0.7
Family relationship satisfaction	1.3	1.6	3.7	0.5	1.2	1.3	0.8	1.6	1.3	1.2	1.1	1.7	0.9	1.7	0.5	1.8	0.8	0.7	1.5	1.9	1.0	1.2
Leg pain on walking	1.3	1.6	3.3	0.4	1.4	1.8	0.1	1.4	0.5	1.1	1.1	0.9	0.8	1.5	1.8	1.7	1.3	-0.1	1.6	1.7	1.2	1.6
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.8	-1.7	-1.2	-1.5	-0.0	-1.3	0.7	-1.6	-1.0	-2.0	-1.2	-1.4	-0.7	-1.4	-1.0	-0.7	-1.4	-1.4	-1.2	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.6	-2.1	-0.9	-1.1	-1.4	-1.1	-0.9	-0.2	-1.3	-0.4	-1.1	-0.7	-1.8	-0.9	-1.4	-1.4	-1.3	-1.5	-1.5	-1.1
Exposure to tobacco smoke at home	1.2	1.3	3.0	1.4	1.4	1.3	0.4	1.4	0.7	0.7	0.6	1.2	1.2	1.3	0.7	1.0	1.0	0.9	1.7	1.2	1.6	1.2
Peak expiratory flow (PEF)	1.2	2.8	6.2	-2.5	-2.1	-0.9	-1.8	-1.9	-2.1	-0.9	-0.0	-1.4	-2.1	-1.0	-1.1	-1.6	-2.0	-1.9	-1.6	-0.6	-2.1	-1.9
High blood pressure (siblings)	1.2	1.8	4.9	-0.7	-0.8	-0.8	-1.7	-0.7	2.2	-1.9	-2.0	-1.7	-1.2	-1.3	-1.5	-1.6	-0.7	0.4	-1.1	-1.2	-1.0	-0.8
Qualifications: College or University degree	1.2	3.8	7.1	1.6	1.8	1.8	1.6	2.3	1.0	1.7	2.0	1.1	1.8	2.3	1.8	2.3	2.7	2.1	2.5	1.3	2.1	2.1
Comparative height size at age 10	1.2	6.4	14.3	2.7	3.5	3.4	0.3	3.8	1.4	1.9	1.0	1.3	2.7	2.5	3.2	2.6	2.8	3.0	3.1	1.4	2.6	1.5
Overall health rating	1.2	2.6	4.5	-1.4	-1.3	-1.8	-2.0	-1.4	-0.9	-1.3	-1.9	-1.4	-1.7	-1.5	-1.8	-1.7	-2.1	-0.9	-1.7	-1.6	-1.7	-2.0
Smoking status: Previous	1.2	1.7	3.4	-1.6	-1.6	-0.8	-0.9	-1.7	1.1	-1.1	-1.1	-1.0	-1.5	-0.8	-0.8	-1.4	-1.7	-1.8	-1.3	-0.4	-1.7	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	5.5	-1.2	-2.0	-0.8	-1.2	-0.9	-1.7	-2.2	-1.9	-1.1	-2.1	-1.3	-2.3	-1.7	-1.9	-0.9	-1.3	-1.4	-1.4	-1.7
Schizophrenia vs Biploar Disorder	1.1	1.5	8.0	0.8	0.9	2.0	0.6	1.6	-0.7	0.9	1.6	1.1	-0.0	1.6	2.8	1.2	0.8	0.1	1.2	-0.0	0.7	-0.1
Alzheimer’s Disease (in father)	1.1	1.2	2.6	-1.0	-1.0	-1.2	-0.9	-1.1	-0.1	0.2	-0.4	-1.2	-1.6	-1.2	-1.5	-1.0	-1.4	-0.2	-1.5	-1.2	-1.1	-1.2
Type 2 Diabetes (T2D) (2012)	1.1	1.2	6.0	-2.5	-1.3	-0.9	-0.1	-1.1	-0.4	-0.2	0.6	-0.7	-1.2	-0.0	-1.7	-0.7	-0.8	-1.7	-1.0	-0.1	-1.5	-0.7
Blood Platelet Count	1.1	13.0	32.4	1.0	3.8	4.4	3.3	4.4	-0.2	3.8	3.8	3.7	3.9	5.4	5.7	4.0	4.1	1.4	4.4	1.2	2.2	1.8
Diabetes (mother)	1.1	1.4	3.9	-1.9	-1.8	-1.4	-0.0	-1.3	-1.1	-0.3	0.3	-0.6	-1.6	-0.1	-1.7	-0.5	-0.8	-2.0	-0.7	0.8	-1.3	-0.9
Taking other prescription medications	1.1	1.7	5.0	-1.1	-0.8	-0.9	-0.6	-1.1	-1.0	-1.2	-2.2	-1.4	-0.9	-1.6	-0.8	-1.4	-1.4	-0.8	-1.5	-1.7	-1.5	-1.7
Mouth/teeth dental problems	1.1	1.6	6.3	2.1	0.6	1.2	0.8	0.8	0.4	0.4	1.2	1.2	1.3	0.7	0.8	1.2	1.3	0.5	1.6	1.2	2.0	2.5
Allergy	1.1	2.4	7.2	0.7	0.9	1.2	1.7	1.1	-1.1	1.9	2.3	2.3	1.4	1.6	1.0	2.0	1.4	-0.2	1.4	2.7	1.2	1.2
High cholesterol (Self-reported)	1.1	2.0	5.3	-1.9	-1.6	-1.2	-1.0	-1.8	0.1	-1.2	-0.8	-0.8	-1.4	-1.1	-2.3	-1.6	-1.5	-2.0	-1.2	-1.3	-1.5	-0.5
Schizophrenia (2014)	1.0	2.1	9.7	-0.3	0.4	1.5	1.0	0.9	-0.8	2.0	3.1	1.0	1.0	2.0	0.9	1.8	1.2	-0.5	1.6	1.6	1.1	1.8
Smoking Status	1.0	2.3	4.5	-1.8	-0.7	-1.3	-1.2	-1.0	1.6	-1.2	-2.1	-2.1	-1.7	-1.5	-0.8	-1.5	-1.7	-0.5	-1.9	-0.7	-1.8	-2.0
Severe depression (siblings)	1.0	1.1	4.2	-1.0	-1.1	-1.4	-2.1	-1.1	-1.7	-0.3	-0.1	-1.7	-0.2	-0.8	-0.9	-0.3	-1.1	-1.7	-0.2	0.2	-0.2	0.2
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	5.1	-0.3	1.2	0.6	1.3	1.0	0.3	1.8	0.8	2.3	0.5	1.5	1.1	1.1	0.5	0.8	0.8	0.5	0.3	-0.4
Medication: Levothyroxine sodium	1.0	1.7	4.1	-1.9	-1.2	-0.8	-1.1	-1.5	-0.5	-0.5	-0.1	-0.3	-2.0	-1.0	-1.6	-1.4	-1.6	-1.2	-1.3	-1.8	-1.4	-1.3
Sitting height	1.0	7.3	18.8	3.0	3.8	4.3	0.2	4.2	0.3	2.1	2.0	1.4	2.7	2.4	3.1	3.1	2.7	3.4	2.9	1.7	2.4	0.7
Fluid intelligence score	1.0	2.2	7.3	-0.4	0.4	0.6	0.8	0.2	0.2	2.6	2.7	1.5	1.4	2.2	0.9	1.9	1.2	-1.2	1.6	1.5	1.1	1.7
Arm fat percentage (right)	1.0	3.7	14.5	-3.8	-2.2	-1.5	-0.5	-2.5	-3.0	0.0	1.1	-0.8	-1.4	-0.1	-1.6	-1.2	-2.2	-3.6	-1.3	-0.9	-2.1	-1.3
Medication: Omeprazole	1.0	1.2	2.4	-1.2	-1.1	-1.2	-1.5	-1.4	-0.4	-0.2	-0.6	-0.1	-1.2	-0.6	-1.1	-1.0	-1.5	-1.4	-1.0	-0.8	-1.4	-1.2
Had major operations	1.0	1.1	3.0	0.1	-1.1	-0.9	-1.7	-0.9	0.0	-1.4	-0.7	-1.4	-0.7	-1.7	-0.6	-1.2	-1.3	-0.4	-1.4	-0.5	-0.7	-1.1
Medication: Gliclazide	1.0	1.1	3.5	-1.7	-1.3	0.0	-1.4	-0.6	-0.2	-0.9	-0.5	-0.9	-1.9	-0.3	-0.3	-0.8	-0.7	-1.0	-0.5	-1.0	-1.6	-1.6
Financial situation satisfaction	1.0	1.3	8.0	-2.0	-1.5	0.1	-0.6	-0.6	-1.1	-1.1	-0.5	-1.2	-1.2	0.4	-0.0	-0.4	-0.8	-2.8	-0.2	-0.2	-1.5	-0.8
Ever smoked	1.0	1.8	6.5	-2.6	-1.2	-0.6	-1.3	-1.1	0.8	-0.7	-0.8	-0.8	-1.8	-0.1	-0.9	-1.2	-1.5	-1.6	-1.1	-0.1	-2.4	-1.7
Intelligence (Savage-Jansen 2018)	0.9	2.6	6.5	0.2	1.0	1.3	0.6	1.2	0.2	2.5	2.5	1.1	1.8	2.5	0.8	2.1	2.0	-0.7	2.1	1.7	1.4	1.8
Worry (Nagel 2018)	0.9	2.0	9.5	0.5	-0.1	-1.6	0.3	0.2	1.6	-2.4	-3.1	-2.1	-0.2	-1.6	-0.9	-1.3	-0.3	1.0	-0.9	-2.1	-0.5	-1.0
HDL Cholesterol	0.9	1.5	4.5	0.9	0.7	1.0	0.1	0.7	-1.2	1.7	1.8	0.9	1.6	1.4	0.8	1.3	0.6	-0.1	1.6	1.0	1.8	2.1
Trunk fat-free mass	0.9	5.4	11.9	1.7	3.3	3.3	0.1	3.4	0.7	2.4	1.7	1.5	2.5	2.7	2.5	2.8	2.7	2.1	2.7	2.2	1.6	0.6
Trunk predicted mass	0.9	5.3	11.8	1.7	3.3	3.4	0.1	3.4	0.7	2.3	1.6	1.5	2.5	2.7	2.5	2.8	2.7	2.1	2.7	2.2	1.6	0.6
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	5.9	1.1	1.6	2.4	0.7	1.9	1.4	0.3	0.8	0.4	0.6	1.0	1.5	0.9	1.2	2.1	1.2	0.5	0.8	0.6
Eye problems/disorders: None of the above	0.9	1.1	3.2	0.3	-0.6	-1.1	-0.3	-0.5	-0.2	-1.2	-1.4	-0.5	-0.8	-1.7	-0.5	-1.2	-0.9	0.8	-1.4	-1.6	-0.9	-1.8
Medication: Allopurinol	0.9	1.2	2.6	0.6	1.4	1.1	0.6	1.1	1.6	1.2	0.9	0.8	1.0	1.4	0.7	0.8	1.3	0.9	1.3	1.0	1.0	1.0
Arm predicted mass (right)	0.9	4.7	11.5	1.6	3.1	2.9	0.1	3.4	1.0	2.0	1.2	1.8	2.3	2.6	2.4	2.6	2.6	1.6	2.5	2.1	1.5	0.2
Average weekly red wine intake	0.9	1.3	3.1	-1.0	-1.3	-1.2	-1.4	-1.2	1.0	-0.6	-1.1	-1.8	-0.9	-1.6	-0.6	-1.1	-1.5	-0.1	-1.6	-1.1	-1.0	-0.7
Commuting to job workplace: Walk	0.9	1.0	2.7	-1.7	-1.1	0.2	0.3	-1.1	1.0	-0.7	0.1	-1.1	-1.3	-0.4	-0.6	-1.0	-0.7	-0.5	-0.9	-0.8	-1.7	-1.6
Alzheimer’s Disease (in mother)	0.8	0.9	3.4	0.9	0.8	1.4	-1.0	1.1	1.5	0.1	-0.4	0.3	1.0	1.0	1.9	0.3	1.5	0.4	0.9	-0.1	0.4	-0.0
Major Depression (MDD)	0.8	1.0	3.8	-0.9	-1.0	-0.5	-0.6	-1.0	1.6	-1.2	-0.9	-2.0	-0.8	-1.4	-0.9	-1.0	-0.7	-0.7	-0.8	-0.6	-0.6	-0.2
Mean Putamen Volume	0.8	1.0	5.1	1.3	0.6	1.4	0.6	1.5	-0.4	0.3	0.1	0.3	1.0	1.0	2.2	0.8	0.9	0.5	1.4	0.3	0.8	-0.4
Sensitivity / hurt feelings	0.8	1.4	4.5	-1.0	-1.1	-2.1	-1.9	-1.0	-0.1	-1.0	-1.7	-1.4	-0.4	-1.4	-0.6	-1.0	-1.4	-0.9	-1.2	-0.6	-1.0	-1.1
Number of live births	0.8	1.1	3.2	-0.7	-1.0	-0.6	-1.8	-1.2	-0.4	-0.9	0.0	-0.6	-1.2	-1.2	-1.8	-1.3	-1.3	-0.7	-1.1	-0.1	-1.2	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.8	-0.7	-1.2	-1.5	-0.3	-1.4	-1.7	-0.7	-1.0	-0.8	-0.5	-1.1	-1.1	-0.7	-0.4	-0.8	-1.0	-1.0	-0.5	0.0
Prospective memory result	0.8	1.0	2.3	-0.2	-0.8	-1.4	0.7	-1.0	-1.3	-1.0	-1.2	-0.2	-1.1	-1.4	-1.5	-0.9	-1.3	-0.5	-1.0	-1.1	-0.6	-0.3
Standing height	0.8	7.6	15.6	3.9	3.8	3.8	0.4	4.0	2.4	1.5	1.7	1.1	3.0	1.4	2.5	2.9	2.8	3.9	3.0	1.4	3.0	1.9
Leg fat percentage (right)	0.8	3.0	11.9	-3.1	-1.9	-0.9	-0.9	-2.1	-2.1	-0.7	0.4	-0.8	-1.6	-0.4	-1.4	-1.4	-1.9	-3.5	-1.3	-1.7	-2.0	-1.4
Arm fat-free mass (right)	0.8	4.3	10.1	1.5	3.0	2.9	-0.1	3.2	1.0	2.0	1.2	1.6	2.2	2.4	2.5	2.5	2.4	1.6	2.3	2.2	1.4	0.2
Exposure to tobacco smoke outside home	0.8	1.1	3.6	-1.9	-1.1	-1.1	-0.8	-1.1	-0.9	0.3	0.2	-0.7	-1.1	0.1	-1.9	-0.3	-1.4	-1.8	-0.7	-0.1	-1.0	-0.5
Shortness of breath walking on level ground	0.8	0.9	2.1	-1.4	-0.9	-0.9	-1.3	-1.0	-0.7	-0.8	-0.4	-0.4	-1.4	-0.4	-1.2	-1.0	-1.2	-0.8	-0.8	-0.6	-1.3	-0.6
Medication: Seretide 50 evohaler	0.8	0.9	2.7	-0.4	-0.1	1.0	-1.4	0.0	-0.1	-1.4	-0.7	-0.7	-1.0	-1.0	0.0	-1.1	-1.3	0.6	-0.8	-1.6	-1.0	-1.3
Chest pain or discomfort	0.8	1.2	3.3	-1.8	-0.8	-1.1	-1.6	-0.9	-0.8	-0.1	-0.3	-1.0	-1.3	-0.3	-1.4	-0.5	-1.5	-1.6	-0.8	-0.6	-1.2	-0.7
Whole body fat-free mass	0.8	4.4	9.7	1.4	3.1	2.9	0.2	3.1	0.5	2.3	1.7	1.5	2.2	2.5	2.3	2.6	2.3	1.8	2.3	2.1	1.4	0.3
Whole body water mass	0.8	4.5	10.0	1.4	3.1	2.9	0.2	3.2	0.5	2.3	1.7	1.5	2.2	2.5	2.3	2.6	2.3	1.8	2.4	2.2	1.4	0.4
Medication: Bendroflumethiazide	0.8	1.2	2.9	-0.9	-0.8	-1.4	-1.1	-0.9	0.6	-1.0	-1.7	-0.8	-1.1	-1.1	-1.6	-1.4	-0.8	-0.2	-1.0	-1.4	-0.9	-0.7
Leg fat percentage (left)	0.8	2.8	9.5	-3.0	-1.7	-1.0	-0.9	-2.1	-1.9	-0.7	0.2	-0.7	-1.6	-0.4	-1.6	-1.4	-1.9	-3.1	-1.3	-1.6	-2.0	-1.4
Age started oral contraceptive pill	0.8	1.0	4.1	0.2	-0.3	-0.2	0.3	-0.2	0.9	-1.4	-1.7	-0.9	-0.3	-1.3	0.6	-1.0	-0.7	0.4	-1.1	-2.0	-0.8	-1.5
Ulcerative Colitis (UC)	0.7	1.3	4.1	0.3	1.3	0.1	1.2	1.4	0.8	1.2	1.4	0.8	1.1	2.0	1.3	1.4	1.1	0.1	1.5	1.2	0.9	1.0
Fasting Glucose	0.7	0.9	2.8	-1.4	-0.6	-0.1	0.4	-0.8	-0.9	0.5	1.6	-0.5	-1.0	-0.6	-1.7	-0.6	-1.2	-0.3	-1.1	-0.7	-0.9	-1.2
Primary Biliary Cirrhosis	0.7	1.1	2.6	1.0	1.1	1.0	0.5	0.9	0.2	1.6	1.5	0.6	1.5	0.9	0.8	1.2	0.9	0.7	1.0	0.4	1.2	1.2
Allergy or Eczema	0.7	1.8	7.7	-1.2	-1.1	-0.7	-1.3	-0.9	0.2	-1.4	-1.6	-1.6	-1.3	-0.9	-0.5	-1.7	-1.0	-0.4	-1.3	-2.8	-1.6	-1.8
Hayfever, allergic rhinitis or eczema	0.7	1.6	5.4	-1.3	-0.9	-0.7	-1.2	-0.8	0.5	-1.3	-1.6	-1.6	-1.4	-1.0	-0.7	-1.6	-1.0	-0.1	-1.1	-2.3	-1.5	-1.4
Waist circumference	0.7	2.4	6.3	-2.5	-1.3	-0.8	-1.4	-1.6	-1.0	-0.9	-0.2	-1.2	-1.7	-1.0	-1.7	-1.4	-2.0	-2.2	-1.6	-1.6	-1.9	-1.8
Hair/balding pattern: Pattern 2	0.7	0.9	2.4	-0.7	-1.1	-0.7	-1.5	-1.1	-0.4	-0.8	0.1	-1.4	-0.7	-1.0	-1.2	-0.6	-0.8	-1.3	-1.0	-0.9	-1.0	-0.7
Pain all over the body in last month	0.7	0.8	2.6	-1.0	-0.4	-0.2	-1.6	-0.6	0.6	0.1	-0.2	-1.6	-1.2	-0.8	-0.1	-0.8	-0.8	0.0	-0.8	-0.9	-1.0	-1.6
Medication: Simvastatin	0.7	1.0	5.2	-1.3	-0.9	-0.8	-2.1	-1.3	0.1	-0.4	-0.4	-0.2	-1.3	-0.2	-1.0	-0.7	-0.4	-2.3	-0.5	-0.2	-0.6	-0.0
Alcohol intake versus 10 years previously	0.7	1.1	4.2	2.0	1.0	0.7	1.5	1.1	1.0	-0.4	-0.5	1.8	0.8	0.4	1.4	0.7	1.2	0.4	0.8	0.6	0.9	0.4
Worrier / anxious feelings	0.7	1.4	9.2	0.6	-0.2	-1.0	-0.8	0.2	0.9	-2.0	-3.0	-1.3	-0.6	-1.3	-0.9	-1.2	-0.4	0.3	-0.5	-1.6	-0.6	-1.1
Medication: Paracetamol	0.7	1.1	2.5	-0.7	-1.3	-1.6	-0.6	-1.5	-0.2	-1.2	-1.3	-1.2	-0.6	-1.3	-1.5	-1.1	-0.7	-1.1	-0.9	-1.0	-0.6	-0.1
Glaucoma (self-reported)	0.7	0.9	3.4	-1.9	-0.6	-0.5	-1.3	-0.9	-1.3	-0.1	-0.9	-0.1	-1.1	0.0	-0.6	-0.9	-1.1	-1.3	-0.3	-0.2	-1.1	-0.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	6.0	1.4	0.9	0.5	0.3	0.9	-0.4	0.2	-0.6	-0.2	1.2	-0.2	0.8	-0.1	0.3	2.4	0.4	0.1	1.1	0.5
Mean time to correctly identify matches	0.7	1.3	3.6	-0.7	-1.8	-1.9	-1.1	-1.4	-0.1	-1.3	-1.6	-0.7	-0.6	-1.4	-1.3	-1.2	-1.3	-0.7	-1.0	0.2	-0.6	0.1
Number of full sisters	0.7	0.8	2.3	1.5	0.6	0.9	0.2	0.7	-0.7	0.5	1.1	-0.3	1.2	0.3	0.7	1.2	0.8	-0.5	1.0	0.7	1.3	1.2
Knee pain experienced in last month	0.7	1.1	4.2	-1.1	-1.0	-0.1	-2.1	-0.9	0.6	-1.3	-1.1	-1.6	-0.5	-0.7	0.0	-1.0	-1.2	-1.6	-0.6	-0.7	-1.0	-0.9
Arm fat percentage (left)	0.7	2.7	10.8	-3.3	-1.7	-1.2	-0.1	-2.0	-3.0	0.5	1.5	-0.2	-1.1	0.3	-1.1	-0.7	-1.9	-3.3	-0.9	-0.3	-1.6	-0.9
Medication for cholesterol	0.7	1.1	2.9	1.4	0.4	-0.1	1.2	0.9	-0.6	1.3	0.5	0.8	1.2	0.8	1.7	1.4	1.6	0.8	1.1	1.0	1.1	0.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.8	0.8	0.8	0.8	0.9	0.7	0.0	0.3	0.6	0.5	1.0	1.2	1.6	0.8	1.7	-0.6	1.3	0.3	1.0	1.3
Irritable Bowel Disease (IBD)	0.6	1.5	4.0	0.7	1.5	0.7	2.0	1.9	0.3	0.6	0.8	1.2	0.6	2.0	1.8	1.4	1.1	0.5	1.7	1.1	0.7	0.6
Height	0.6	11.4	30.1	4.5	4.7	5.5	-0.1	4.8	2.8	1.9	1.8	1.1	4.1	1.5	4.1	3.4	3.0	4.7	3.4	0.8	3.4	1.6
Neuroticism	0.6	1.3	5.4	-0.9	-0.5	-0.7	-1.1	-0.4	1.3	-1.6	-2.3	-1.6	-0.1	-1.3	-0.7	-1.3	-0.5	0.1	-1.2	-1.5	-1.1	-1.2
Townsend deprivation index at recruitment	0.6	0.9	3.2	-0.3	0.9	1.0	0.3	1.2	-1.3	1.2	1.1	1.1	-0.4	1.8	0.4	1.2	0.5	-0.0	1.3	0.3	0.3	0.2
Maternal smoking around birth	0.6	0.9	2.4	-1.5	-1.1	0.2	-0.7	-1.2	-0.6	-0.6	-0.4	-0.5	-0.5	-0.6	0.3	-0.9	-1.1	-1.4	-0.9	-1.3	-1.2	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.2	4.9	-2.2	-1.5	-0.6	0.1	-1.3	0.8	0.2	1.2	-0.5	-1.3	-0.0	-0.5	-1.3	-1.1	-0.4	-1.0	-0.9	-1.8	-1.4
Multivitamins +/- minerals	0.6	0.8	3.3	-1.5	-1.1	-1.6	0.0	-1.2	0.2	-0.3	-0.8	-0.8	-0.7	-0.3	-0.4	-0.7	-0.1	-1.8	-0.5	-0.5	-0.8	-0.2
Neuroticism score	0.6	1.3	3.2	-1.2	-0.9	-1.8	-1.0	-0.7	-0.1	-1.2	-1.8	-1.3	-0.4	-1.1	-1.0	-1.2	-0.9	-0.4	-1.1	-1.4	-1.1	-1.1
Falls in the last year	0.6	0.7	2.2	-1.1	-0.8	0.4	-0.6	-0.0	1.3	-1.3	-0.9	-0.5	-1.4	0.1	-0.3	-0.3	-0.2	-0.7	-0.3	-0.8	-1.4	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.0	1.6	0.6	0.6	0.4	1.0	-0.5	-0.7	-1.1	-0.2	1.1	-0.3	-0.2	0.2	0.8	1.7	0.5	0.2	0.9	1.0
Blood clot in the leg (DVT)	0.6	0.7	3.0	-0.6	-0.9	0.3	-0.9	-0.3	-1.5	-0.9	-0.4	-1.2	-1.5	0.1	-0.7	-0.3	-0.4	-1.7	0.1	-0.2	-0.6	-0.5
Body fat percentage	0.6	2.2	8.7	-2.7	-1.6	-1.2	-0.4	-1.9	-2.2	-0.2	1.1	-0.6	-1.0	-0.3	-1.3	-0.9	-1.8	-2.9	-1.0	-0.9	-1.4	-0.9
Medication: Blood pressure	0.6	1.1	6.0	-0.6	-1.2	-2.4	-0.3	-1.4	-0.6	-0.4	-1.2	-0.0	-0.5	-0.9	-1.2	-0.7	-0.5	-1.8	-0.9	-0.7	-0.4	-0.3
Leg fat-free mass (right)	0.6	3.1	7.2	1.0	2.7	2.0	0.4	2.5	-0.0	2.4	1.6	1.3	1.7	2.0	1.9	2.3	1.7	1.6	1.7	2.2	1.2	0.2
Long-standing illness, disability or infirmity	0.6	1.0	3.0	-1.0	-1.0	-0.6	-1.3	-0.8	-1.7	-0.5	-0.7	-0.4	-0.8	-0.5	-0.2	-0.5	-0.9	-1.4	-0.8	-1.2	-1.1	-1.4
Medication: Lisinopril	0.6	0.8	1.9	1.4	0.6	0.6	1.2	0.7	-0.8	0.8	0.8	0.7	1.1	0.8	1.1	1.2	0.9	-0.8	0.8	0.4	1.1	0.6
Pain experienced in last month	0.6	1.0	3.7	0.6	0.7	0.6	1.4	0.5	0.1	1.0	1.5	1.6	0.8	0.8	0.2	1.0	0.5	0.7	0.8	0.9	1.3	1.9
Supplements: Calcium	0.6	0.6	2.8	-0.1	-0.0	1.0	0.2	0.0	0.8	1.0	1.1	0.5	0.6	0.8	-0.7	0.5	1.0	-0.8	0.9	0.1	0.9	1.7
Schizophrenia (2018)	0.5	1.0	4.4	-0.3	0.3	1.2	0.2	0.9	-0.3	1.3	2.1	0.5	0.3	1.5	0.8	1.5	1.0	-0.4	1.2	0.7	0.7	1.1
Bipolar Disorder (2011)	0.5	0.5	2.7	0.0	-0.3	-0.2	-0.5	-0.1	-1.6	1.3	0.5	0.3	0.1	0.8	-1.2	0.4	-0.3	-0.3	0.5	0.8	-0.0	0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.2	0.2	-0.4	-1.2	-0.7	-1.0	-0.1	1.5	1.2	0.1	0.7	-0.6	-0.2	0.3	-0.7	-0.6	-0.4	0.2	0.7	0.6
Diabetes (father)	0.5	0.7	4.4	0.1	-0.0	-1.0	-0.8	-0.3	-2.1	0.1	0.9	0.1	-0.2	-0.0	-0.2	0.5	-0.5	-0.8	0.2	1.9	0.5	0.6
Leg fat-free mass (left)	0.5	2.4	5.2	0.6	2.3	1.9	0.4	2.2	-0.5	2.3	1.7	1.1	1.5	1.9	1.7	2.1	1.3	1.1	1.5	1.8	0.9	-0.1
Trunk fat percentage	0.5	2.1	7.7	-2.6	-1.6	-1.3	-0.4	-2.0	-1.9	-0.2	1.0	-0.6	-1.0	-0.5	-1.3	-0.9	-1.9	-2.8	-1.1	-1.0	-1.3	-0.8
Average weekly fortified wine intake	0.5	0.6	1.7	0.9	0.2	0.9	-0.8	0.9	0.5	0.3	1.0	1.3	0.2	1.1	0.9	1.0	0.9	-0.1	1.1	0.6	0.6	0.4
Serious illness, injury or assault to yourself	0.5	0.7	2.9	-0.7	-0.5	-0.6	-0.9	-1.0	-1.2	0.2	0.0	-0.1	-1.1	-0.4	-1.7	-0.4	-1.3	-0.8	-0.7	0.0	-0.6	-0.5
Leg predicted mass (left)	0.5	2.7	5.7	0.7	2.4	2.0	0.4	2.3	-0.4	2.3	1.8	1.2	1.6	2.0	1.8	2.1	1.4	1.2	1.6	1.9	0.9	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.9	-2.0	-1.6	-0.9	0.1	-1.4	0.7	-0.2	0.8	-0.7	-1.2	-0.2	-0.9	-1.2	-1.1	-0.4	-1.1	-0.4	-1.8	-1.6
Father’s age at death	0.5	0.7	2.1	-1.0	-0.7	-1.1	-1.3	-0.7	0.3	-1.4	-0.3	-0.7	-0.9	-0.7	-0.4	-0.9	-0.6	-0.8	-0.8	-0.6	-1.2	-0.7
Medication: Lansoprazole	0.5	0.6	3.2	-0.0	0.2	-0.7	-1.4	0.0	-1.4	-0.4	-1.4	-0.3	-0.1	-0.4	-1.8	-0.3	-0.5	0.3	-0.4	0.4	0.2	0.9
Arm fat mass (right)	0.5	2.0	8.8	-3.0	-1.3	-0.6	-0.7	-1.4	-2.2	0.3	1.2	-0.5	-1.0	0.4	-0.9	-0.5	-1.5	-2.9	-0.7	-0.3	-1.6	-1.2
Birth weight of first child	0.5	0.8	6.7	-0.0	0.2	1.6	-0.9	0.2	2.6	-0.6	0.0	-0.3	0.6	-0.4	0.7	-0.5	-0.0	0.7	-0.5	-1.0	-0.8	-1.4
Headache pain in last month	0.5	0.9	4.0	-0.4	-0.4	-2.0	-0.4	-0.7	-0.5	-0.8	-1.0	-0.6	-0.5	-1.2	-1.5	-1.2	-1.1	0.2	-1.1	-1.2	-0.5	-0.6
Medication: Ibuprofen	0.5	0.6	2.2	1.5	0.5	0.4	0.3	0.6	0.1	-0.3	-0.6	-0.2	1.4	-0.5	-0.2	0.3	0.8	1.5	0.4	0.1	1.1	1.5
Suffer from ‘nerves’	0.5	0.7	3.9	0.5	0.5	-0.3	1.2	0.8	0.8	-1.1	-1.6	-0.2	1.1	-0.3	0.4	-0.4	0.5	1.0	-0.0	-2.0	-0.1	-0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.0	0.7	-0.2	-1.0	-0.4	-0.1	1.0	-0.9	-1.1	-0.5	-0.0	-1.4	0.1	-1.0	-0.8	1.3	-0.8	-0.5	-0.2	-0.6
Illnesses of father: Heart disease	0.5	0.7	2.6	0.1	-0.7	-1.2	0.4	-1.3	0.6	-0.1	-0.4	-0.5	-0.2	-1.6	-0.9	-0.9	-1.0	0.5	-1.5	-1.0	-0.5	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.6	0.7	0.5	0.6	-0.1	0.7	-1.6	0.6	0.4	0.3	0.3	0.9	0.4	0.7	0.3	0.3	0.9	1.1	0.6	0.6
Friendships satisfaction	0.5	0.6	1.5	1.2	0.5	0.9	-1.2	0.9	0.9	-0.0	0.2	0.2	1.0	0.5	1.2	0.7	0.5	0.3	0.9	0.6	0.5	0.3
Leg predicted mass (right)	0.5	2.9	6.8	1.0	2.6	1.9	0.5	2.5	-0.0	2.3	1.5	1.2	1.7	1.9	1.8	2.2	1.6	1.6	1.7	2.1	1.1	0.1
Average weekly champagne plus white wine intake	0.5	0.6	1.5	-1.1	-1.0	-0.7	-1.2	-0.6	-0.0	-0.7	-0.5	-1.1	-0.8	-0.5	-0.3	-0.3	-1.2	-0.9	-0.8	-0.0	-1.0	-0.9
Eye problems/disorders: Glaucoma	0.5	0.6	2.3	-0.8	0.6	0.9	-1.2	0.3	-1.5	1.0	0.2	0.4	0.4	1.2	0.8	0.5	0.1	-0.8	1.0	1.0	0.2	0.4
Illnesses of father: High blood pressure	0.5	0.7	4.9	-0.2	-0.4	-2.2	-0.0	-0.9	-0.3	-0.1	-0.8	-0.1	-0.5	-0.7	-0.8	-0.8	-0.6	0.2	-0.9	-1.5	-0.5	-0.3
Basal metabolic rate	0.5	2.9	6.4	0.8	2.5	2.4	0.0	2.5	-0.0	2.1	1.7	1.1	1.8	2.2	1.8	2.2	1.7	1.1	1.9	1.8	1.0	0.1
Arm fat-free mass (left)	0.5	2.4	6.6	0.5	2.4	2.5	-0.6	2.6	1.0	1.4	0.9	0.8	1.6	2.0	1.8	1.8	1.8	0.9	1.7	1.3	0.6	-0.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.9	-0.3	-1.0	-0.2	-1.4	-0.9	0.5	-0.8	-0.8	-0.5	-0.4	-1.1	-0.3	-1.1	-0.1	0.3	-1.0	-0.1	-0.8	-1.1
Basal cell carcinoma (self-reported)	0.5	0.5	2.8	0.8	1.1	-0.4	-0.6	0.9	1.1	0.4	-0.8	-0.7	0.3	-0.1	0.0	0.3	-0.0	1.7	0.1	0.4	0.9	0.7
Bipolar Disorder or Schizophrenia	0.4	0.9	3.3	-0.2	0.5	1.0	0.1	0.4	-0.3	1.3	1.8	0.5	0.8	1.0	0.1	1.1	1.1	0.2	0.9	1.3	0.8	1.6
Reaction Time	0.4	0.8	2.9	-0.1	-1.4	-1.7	-0.5	-1.1	-0.8	-1.1	-1.5	-0.4	-0.7	-1.1	-0.8	-0.9	-1.2	-0.3	-0.7	0.4	-0.2	0.3
Breast Cancer	0.4	0.9	4.5	-0.7	-0.5	-0.5	-0.0	-0.6	-1.4	1.4	1.5	0.3	-0.1	0.5	-0.5	0.9	-1.0	-1.0	0.4	2.1	0.8	1.0
Coronary Artery Disease (CAD)	0.4	0.5	2.2	-0.6	-0.6	0.8	0.0	-0.2	-0.1	-1.1	-0.9	-0.1	-1.1	-0.5	-0.2	-0.6	-0.1	-0.3	-0.5	-1.5	-1.1	-0.8
Rheumatoid Arthritis	0.4	0.6	2.2	0.9	1.0	1.5	0.9	0.9	-0.3	0.3	0.5	0.1	0.9	0.5	0.5	0.2	0.8	1.2	0.7	-0.7	0.8	0.4
Lung FVC	0.4	1.8	7.3	-1.3	-1.6	-0.6	-0.9	-0.5	-1.0	-2.7	-2.1	-0.7	-1.8	-0.6	-1.5	-1.5	-1.0	-0.1	-1.1	0.2	-1.8	-1.7
Pack years adult smoking proportion	0.4	0.6	3.1	-0.0	1.3	1.3	1.8	1.0	-0.2	0.7	0.3	-0.2	0.4	0.8	0.8	0.6	0.6	1.0	0.5	-0.6	-0.0	-0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	2.9	-0.1	0.1	0.0	-1.7	-0.2	1.3	-0.6	0.3	0.8	-0.8	0.2	-0.5	-0.0	-0.3	-1.0	0.2	0.1	-0.1	0.4
Body mass index (BMI)	0.4	1.8	8.1	-2.9	-1.1	-0.9	-0.9	-1.4	-1.8	0.3	0.6	-0.4	-1.1	0.3	-0.8	-0.7	-1.3	-2.6	-0.9	-0.3	-1.8	-1.7
Had other major operations	0.4	0.5	1.5	1.0	1.0	0.9	-0.1	1.2	-0.4	0.5	-0.5	0.8	1.0	0.3	0.8	0.9	0.0	0.5	0.5	1.2	0.5	-0.0
Noisy workplace	0.4	0.5	1.3	0.9	1.0	1.1	0.7	0.5	-0.6	0.8	0.2	0.4	1.0	0.4	1.1	0.6	0.9	0.6	0.4	0.3	0.8	0.5
Qualifications: A levels/AS levels or equivalent	0.4	1.0	3.3	-1.2	-1.4	-0.8	-0.2	-1.8	0.2	-0.2	0.8	-0.6	-1.5	-0.6	-1.8	-0.6	-0.9	-1.4	-0.7	-0.5	-0.6	0.4
Mouth/teeth dental problems: Dentures	0.4	0.8	5.5	-0.8	0.6	0.4	-0.8	0.2	0.8	0.4	-0.6	-0.6	-0.0	-0.4	0.9	-0.6	-0.3	0.8	-1.0	-1.1	-1.1	-2.4
Depression (self-reported)	0.4	0.5	1.9	-0.6	-0.5	-1.3	-0.2	-0.4	0.2	-0.6	-1.4	-1.1	0.0	-0.6	-0.2	-0.8	-0.4	-0.0	-0.7	-1.0	-0.8	-0.9
Breastfed as a baby	0.4	0.5	5.4	0.9	0.6	1.0	-0.3	0.4	2.3	-0.2	0.3	-0.2	0.4	-0.3	1.2	-0.1	0.3	0.5	0.1	-0.3	0.3	0.1
Loud music exposure frequency	0.4	0.5	2.8	-1.0	-0.3	-0.1	0.0	-0.5	-1.4	0.8	0.6	-0.6	-0.9	0.2	-0.5	0.2	-0.3	-1.7	-0.1	0.2	-0.3	0.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.2	-1.5	-0.8	-0.3	-1.1	-0.8	-0.5	-0.1	0.4	0.2	-1.2	-0.1	-0.9	-0.8	-0.8	-1.1	-0.7	-1.4	-1.1	-1.1
Number of full brothers	0.4	0.5	2.3	-1.1	-0.6	-0.4	0.2	-0.9	1.0	0.3	0.6	0.4	-0.6	0.4	0.4	-0.2	0.2	-1.5	-0.3	-0.3	-0.9	-0.7
Age at first live birth	0.4	0.7	3.2	0.6	-0.6	-0.5	-0.5	-0.6	0.2	-0.6	-0.2	-0.9	-0.7	-1.5	-0.8	-1.1	-0.7	0.7	-1.2	-1.8	-0.4	-1.0
Health satisfaction	0.4	0.6	3.1	-0.7	-0.4	-0.8	-0.9	-0.8	0.2	-0.1	1.0	0.1	-0.8	-0.3	-0.6	0.0	-1.4	-1.8	-0.5	-0.1	-0.8	-0.3
Emphysema/chronic bronchitis	0.4	0.5	2.9	0.2	-0.1	-0.6	-0.2	-0.1	1.7	-0.7	-1.5	-1.2	-0.2	-0.5	0.2	-0.4	0.2	0.2	-0.4	-0.9	-0.3	-0.6
Osteoporosis (self-reported)	0.4	0.5	3.1	0.7	0.8	0.7	0.8	0.1	0.6	0.9	0.0	0.5	0.4	-0.7	-0.8	-0.2	0.2	1.8	-0.3	-0.1	0.5	0.1
Arm fat mass (left)	0.4	1.6	7.8	-2.8	-1.0	-0.5	-0.6	-1.2	-2.0	0.5	1.2	-0.2	-0.8	0.5	-0.7	-0.3	-1.3	-2.7	-0.5	-0.0	-1.4	-1.0
Hearing aid user	0.4	0.5	1.3	0.5	1.1	0.5	-0.3	0.9	0.4	0.8	0.6	-0.0	0.6	0.7	-0.1	0.7	0.8	0.8	0.7	0.8	0.9	1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	2.4	-0.5	-0.8	0.3	-0.8	-0.1	-1.4	-0.7	-0.3	-1.0	-1.4	0.2	-0.7	-0.1	-0.3	-1.6	0.2	0.1	-0.5	-0.4
Arm predicted mass (left)	0.4	2.3	6.1	0.5	2.3	2.5	-0.2	2.5	1.0	1.4	0.9	0.7	1.6	1.9	1.8	1.7	1.8	1.0	1.6	1.2	0.6	-0.3
Crohns Disease (2017)	0.3	0.6	2.9	0.3	0.6	0.6	1.7	1.2	-0.3	-0.9	-0.7	0.7	-0.7	0.8	1.1	0.1	0.4	0.6	0.5	-0.0	-0.5	-1.0
HbA1C	0.3	0.4	1.7	-0.8	-0.6	-0.1	0.2	-0.7	1.0	-0.6	0.4	-0.3	-0.7	-0.4	-0.9	-0.2	0.2	-1.3	-0.4	0.3	-0.4	-0.2
Respiratory disease	0.3	0.6	2.8	1.7	0.9	-0.5	0.3	0.8	0.7	-0.3	-1.0	-0.2	0.7	0.0	0.9	0.5	0.4	1.2	0.5	0.0	1.1	0.8
Chronotype (morning person)	0.3	0.7	2.9	-1.7	-0.8	0.5	0.8	-0.4	0.3	0.5	1.1	1.1	-0.8	1.5	0.8	0.2	-0.1	-1.6	0.4	0.2	-0.6	-0.2
Hand grip strength (left)	0.3	0.7	2.7	0.2	1.1	0.8	-1.4	1.1	1.3	0.1	0.3	-0.3	0.6	0.7	0.7	0.9	1.6	-0.0	0.6	1.2	0.3	-0.0
Average weekly spirits intake	0.3	0.4	1.3	-0.9	0.2	0.2	-0.4	-0.3	0.5	1.1	1.1	0.4	0.6	0.8	0.7	0.3	0.3	-1.1	0.1	0.9	-0.4	0.0
Hearing difficulty/problems: Yes	0.3	0.4	1.6	-0.1	0.5	0.9	-1.3	0.6	-0.8	0.8	0.4	0.2	0.2	0.8	0.8	0.6	0.3	-0.1	0.8	0.5	0.3	0.5
Medication for hormone replacement therapy	0.3	0.4	1.3	0.3	1.1	0.6	0.9	0.6	1.1	0.0	0.4	0.9	0.4	0.6	0.1	0.2	0.3	0.3	0.5	0.7	0.1	0.4
Vitamin and mineral supplements	0.3	0.4	1.3	0.2	0.1	0.7	-0.5	0.0	0.6	-0.8	-0.4	-0.4	-0.5	-0.8	-0.1	-0.5	-1.0	1.1	-0.7	-0.6	-0.4	-0.9
Current tobacco smoking	0.3	0.5	2.1	-0.6	1.0	-0.6	0.1	0.8	1.5	0.3	-1.0	-0.8	-0.5	0.1	0.1	0.2	0.3	0.7	-0.4	0.5	-0.5	-1.0
Qualifications: CSEs or equivalent	0.3	0.4	0.9	0.4	0.8	0.5	0.7	0.9	-0.1	0.2	0.7	0.6	0.6	0.6	1.0	0.5	0.8	0.3	0.7	0.5	0.2	-0.2
Stomach or abdominal pain in last month	0.3	0.4	1.8	-0.1	-0.3	-0.8	-0.2	0.2	-1.3	-0.9	-1.0	-0.5	-0.6	-0.2	-1.4	-0.1	-0.2	-0.3	-0.1	-0.2	-0.1	-0.2
Supplements: Glucosamine	0.3	0.4	1.3	-0.1	-0.7	-0.5	0.2	-1.2	0.8	-0.3	0.1	-0.8	0.5	-1.0	-0.5	-0.8	-0.2	-0.3	-0.6	-1.0	0.1	0.6
Hearing difficulty/problems with background noise	0.3	0.4	1.8	-0.4	-0.2	0.5	-1.4	-0.2	0.2	-0.2	-0.6	-0.6	-0.2	0.0	0.9	-0.4	-0.2	-0.8	-0.3	-0.5	-1.0	-1.3
Qualifications: None of the above	0.3	0.6	1.9	-0.1	0.4	-0.6	-0.2	-0.3	0.6	-0.0	-0.8	0.0	-0.5	-1.0	-0.3	-0.9	-1.2	1.1	-1.1	-0.9	-0.9	-1.4
Impedance of arm (right)	0.3	1.5	3.5	-0.1	-1.7	-1.1	1.3	-1.7	-0.6	-1.5	-0.0	-1.1	-0.8	-1.9	-1.5	-1.2	-1.5	-0.3	-1.0	-1.8	-0.1	0.8
Hip circumference	0.3	1.1	4.7	-0.6	1.1	1.3	0.4	0.9	-0.9	1.5	2.2	1.2	0.4	1.7	0.7	1.1	0.4	-0.4	1.0	1.2	0.1	-0.2
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	-0.6	-0.6	-0.1	0.2	-0.2	0.8	-1.2	-0.6	-0.8	-0.7	-0.6	-0.5	-1.0	-0.6	0.1	-0.6	-0.1	-0.6	-0.8
Pulse rate	0.3	0.4	2.3	-1.0	-0.1	-1.1	1.5	-0.5	-0.2	1.2	0.3	-0.7	0.1	0.1	-1.0	0.2	-0.0	0.0	-0.2	0.1	-0.0	0.6
Asthma	0.3	0.6	2.7	0.3	-0.4	-0.9	-1.7	-0.5	1.1	-1.1	-1.1	-0.4	-0.8	-0.8	-1.1	-0.7	-0.7	0.2	-0.6	-0.7	-0.2	0.1
Hair/balding pattern: Pattern 4	0.3	0.8	3.3	0.2	0.3	-0.3	1.0	0.8	-1.7	1.0	-0.1	1.4	0.7	1.2	0.8	0.8	0.6	0.4	0.9	1.8	0.5	-0.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.7	0.3	-0.4	-0.4	1.3	-0.7	-0.6	0.9	0.7	0.3	0.8	0.2	0.2	0.7	0.4	-0.5	0.3	0.4	1.0	1.6
Medication: Amlodipine	0.3	0.4	2.5	-0.1	0.1	-0.1	-0.4	-0.4	-0.7	0.1	-0.1	-0.3	-0.1	-0.9	0.0	-0.5	-0.6	0.6	-1.0	-1.6	-0.5	-1.2
Comparative body size at age 10	0.3	0.9	4.0	-0.7	0.7	0.9	-0.5	0.7	-0.8	0.8	2.0	0.5	-0.4	1.7	0.3	1.0	0.1	-0.3	0.9	1.7	0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.5	-0.3	-0.2	0.1	0.8	-0.1	-1.2	0.2	0.2	0.7	0.5	0.5	0.3	0.3	0.4	-1.2	0.3	-0.3	-0.1	0.4
Leg fat mass (right)	0.3	1.2	5.8	-2.2	-0.7	-0.1	-0.5	-0.9	-1.7	0.5	1.2	-0.1	-0.7	0.4	-0.5	-0.2	-1.0	-2.4	-0.4	-0.6	-1.2	-1.1
Age at last live birth	0.3	0.5	1.7	0.8	-0.0	0.1	-0.6	-0.0	0.3	-0.7	-0.0	-1.0	-0.4	-1.1	-1.0	-0.8	-0.4	1.3	-0.7	-1.1	-0.3	-0.4
Eye problems/disorders: Cataract	0.3	0.3	3.0	-0.7	-0.0	0.1	0.3	0.0	1.7	-0.6	0.1	-0.3	-0.6	0.5	-0.6	-0.2	0.1	-0.0	0.1	0.5	-0.6	0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	4.2	-0.1	-0.1	-0.4	0.3	-0.2	-2.0	0.2	0.7	0.4	-0.0	0.6	-0.8	0.3	0.2	-0.6	0.4	0.9	0.2	0.3
Illnesses of father: None of the above (group 1)	0.3	0.4	1.8	-0.3	-0.1	0.6	-0.3	0.3	-0.1	-0.2	0.4	0.6	0.2	0.7	-0.5	0.5	0.6	-0.7	0.9	1.1	0.5	1.3
Smoking status: Current	0.3	0.5	2.4	-1.0	0.6	-0.5	-0.4	0.6	1.5	-0.0	-1.1	-1.0	-0.8	-0.1	-0.1	-0.1	0.0	0.4	-0.6	0.2	-0.8	-1.1
Commuting to job workplace: Public transport	0.3	0.3	1.3	-0.1	0.2	0.8	0.7	0.1	-0.7	0.8	1.1	0.1	0.8	0.3	1.1	0.3	0.1	0.4	0.1	0.3	0.0	-0.3
Average weekly beer plus cider intake	0.3	0.4	1.3	-0.6	-0.4	-0.1	-0.9	-0.6	1.0	-0.3	-0.0	-0.7	-0.8	-0.5	-1.1	-0.5	-0.4	-1.2	-0.5	-1.0	-0.3	-0.1
Diastolic blood pressure, automated reading	0.3	0.8	5.2	-0.5	0.7	1.0	2.3	0.5	1.5	0.4	1.1	0.1	0.5	1.1	0.2	0.6	1.3	-0.1	0.9	-0.3	0.5	0.7
Leg fat mass (left)	0.3	1.1	5.1	-2.2	-0.6	-0.3	-0.5	-1.0	-1.6	0.4	1.0	-0.2	-0.7	0.4	-0.6	-0.4	-1.0	-2.2	-0.5	-0.6	-1.2	-1.2
Bipolar Disorder (2018)	0.2	0.3	1.4	0.3	0.4	0.0	-0.1	-0.4	-0.1	0.5	0.4	0.2	0.9	-0.3	-0.9	-0.1	0.5	0.8	-0.1	1.2	0.4	1.1
Alzheimer’s Disease (including proxy)	0.2	0.4	1.3	0.9	0.6	0.6	-1.1	0.8	0.8	0.3	-0.8	-0.6	0.2	-0.0	0.3	0.0	0.7	0.8	-0.1	-0.3	0.4	-0.2
Ovarian Cancer	0.2	0.3	1.2	-0.9	-0.5	-0.3	-0.3	-0.4	-0.7	-0.2	0.2	-0.9	0.0	-0.1	-0.7	-0.2	-1.1	-0.2	-0.0	-0.4	0.1	0.6
LDL Cholesterol	0.2	0.3	1.1	-0.4	0.0	-0.2	0.2	-0.1	0.7	0.5	0.8	-0.0	-0.2	0.7	-0.9	0.5	0.5	-1.0	0.6	0.3	0.4	1.0
Blood Red Count	0.2	2.1	9.4	-2.1	-1.7	-2.2	-0.3	-2.1	-3.1	-0.1	-0.3	-1.5	-0.6	-1.0	-0.8	-1.1	-1.8	-1.2	-1.3	-0.3	-1.2	-0.8
Heel T-Score	0.2	1.8	6.7	-2.0	-2.1	0.5	-0.0	-1.7	0.4	-1.3	0.7	-0.7	-0.9	-0.4	0.3	-1.6	-0.9	-1.9	-0.9	-2.6	-1.9	-1.3
Systolic Blood Pressure	0.2	1.0	3.0	-0.7	-0.7	-0.2	0.9	-1.2	1.2	-1.5	-0.7	-1.4	-0.5	-0.8	-1.5	-0.8	-0.2	-1.2	-0.6	-1.7	-0.2	0.3
Relative age of first facial hair	0.2	0.5	2.0	-0.5	-0.5	-0.0	-0.0	-0.5	-0.7	0.8	1.2	0.3	0.1	0.1	-1.1	0.4	-0.7	-1.1	0.2	0.2	0.5	1.4
Systolic blood pressure, automated reading	0.2	0.6	2.8	-1.3	-0.3	1.1	1.3	-0.5	0.8	-0.5	0.5	-0.5	-0.2	0.5	-0.2	-0.0	0.5	-1.7	0.2	-1.3	-0.3	0.2
Age when periods started (menarche)	0.2	0.6	2.6	-0.7	-0.6	-1.6	-0.3	-1.0	1.2	0.2	0.1	-0.8	-0.1	-0.9	-1.2	-0.4	-0.7	-0.7	-0.8	-0.6	-0.1	0.3
High blood pressure (mother)	0.2	0.3	1.6	0.8	-0.2	0.8	0.0	0.0	0.2	0.1	-0.1	1.3	-0.0	0.2	-0.6	0.2	-0.1	-0.2	0.3	1.0	0.5	0.2
Impedance of leg (left)	0.2	0.9	3.8	1.0	-0.7	-0.5	0.3	-0.6	0.7	-1.9	-0.7	-0.6	-0.2	-1.3	-1.1	-0.9	-0.2	0.0	-0.1	-1.8	0.5	1.3
Trunk fat mass	0.2	0.9	4.3	-2.0	-0.6	-0.3	-0.3	-0.9	-1.5	0.5	1.4	-0.1	-0.3	0.3	-0.6	-0.1	-1.0	-2.1	-0.3	-0.4	-0.8	-0.6
Forced vital capacity (FVC)	0.2	0.6	2.6	0.7	0.9	1.5	-0.4	1.5	-0.7	-0.7	-0.1	0.2	-0.3	0.5	0.3	0.3	0.6	1.6	0.8	0.8	0.1	-0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	-0.7	-0.0	-0.2	0.1	-0.1	-0.8	0.8	0.8	-0.6	-0.2	0.1	-0.1	0.2	-0.6	-0.1	0.2	0.1	0.3	0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.6	-0.8	-0.4	-0.8	-1.2	-0.2	-0.6	0.3	-0.6	-0.5	0.3	0.1	0.7	0.1	0.1	-0.7	0.2	-0.1	0.2	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	3.1	-1.1	-0.7	0.2	-1.5	-0.1	-1.8	-0.9	-0.0	-0.5	-1.6	-0.2	-0.9	-0.6	-0.6	-0.4	-0.3	0.2	-1.2	-1.3
Happiness	0.2	0.2	1.4	-0.6	-0.4	-0.2	-0.2	0.1	0.4	-0.7	-0.4	-0.9	-0.2	0.3	0.7	0.3	-0.4	-1.2	0.3	-0.3	-0.3	-0.1
Illnesses of mother	0.2	0.2	1.5	0.0	-0.1	-1.2	-0.1	-0.3	-0.7	-0.2	-0.2	-1.2	0.2	-0.6	0.6	0.1	-0.1	0.0	-0.2	-0.1	0.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	2.3	-0.5	-0.8	0.1	-1.2	-0.2	-0.7	-0.9	-0.5	-0.3	-1.5	-0.2	-0.9	-0.6	-0.5	-0.6	-0.2	-0.1	-0.7	-1.0
Impedance of arm (left)	0.2	0.9	2.2	0.4	-1.2	-0.9	1.4	-1.4	-0.4	-1.1	0.4	-0.4	-0.6	-1.5	-0.8	-0.8	-1.3	-0.1	-0.7	-1.1	0.3	1.1
Gout (self-reported)	0.2	0.3	1.2	-0.6	0.7	0.5	0.2	0.2	1.1	0.8	0.8	0.0	0.2	0.9	0.0	0.1	0.3	0.2	0.6	0.7	0.0	0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.3	1.2	0.4	0.4	0.3	0.3	0.7	0.2	-0.1	0.7	0.8	-0.5	0.1	0.2	0.5	1.0	0.1	-0.4	0.6	0.4
Worry too long after embarrassment	0.2	0.4	1.8	-0.8	-0.3	-0.8	-1.3	-0.3	0.2	-0.3	-1.3	-0.6	-0.1	-0.4	-0.2	-0.6	-0.2	-0.1	-0.4	-0.6	-0.4	-0.2
Migraine (self-reported)	0.2	0.3	0.9	-0.1	0.8	-0.4	0.7	0.7	-0.8	0.9	0.2	-0.1	0.1	0.5	0.7	0.5	0.1	0.9	0.1	0.6	0.3	-0.0
Heart disease (mother)	0.2	0.2	0.9	-0.1	0.4	0.9	-0.7	0.2	0.5	0.2	-0.1	0.0	-0.2	-0.1	-0.9	-0.2	0.2	0.4	-0.2	-0.9	-0.1	-0.4
Whole body fat mass	0.2	0.9	4.7	-1.9	-0.5	-0.2	-0.2	-0.7	-1.9	0.8	1.6	0.0	-0.1	0.6	-0.4	0.2	-0.8	-2.2	-0.1	-0.1	-0.7	-0.5
Alcohol intake frequency.	0.2	0.5	6.3	0.1	-0.1	-0.5	0.1	0.0	-2.5	-0.4	-0.5	-0.7	0.2	-0.6	0.1	-0.1	-0.6	-0.2	-0.2	0.0	0.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.4	-0.1	-0.8	-0.4	-1.2	-0.4	-0.6	-0.3	0.1	-0.7	-0.6	-0.2	-0.4	-0.5	0.0	-0.9	-0.2	0.0	0.1	-0.2
Supplements: Vitamin C	0.2	0.2	0.7	0.4	0.1	0.7	-0.4	-0.0	-0.5	0.7	0.3	0.1	0.8	0.1	0.3	0.4	0.4	-0.0	0.3	-0.4	0.7	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.2	0.3	0.2	0.6	-0.9	-0.1	-1.1	0.4	0.0	-0.2	-0.2	-0.1	-0.3	-0.3	-0.1	0.2	0.1	-0.6	-0.1	-0.7
Back pain experienced in last month	0.2	0.4	1.6	-0.1	-0.1	-0.5	0.2	0.1	0.6	-0.7	-1.2	-0.6	-0.3	-0.4	-0.7	-0.6	-0.1	0.5	-0.6	-0.1	-0.8	-1.1
Breast cancer (self-reported)	0.2	0.3	1.2	-0.6	-0.2	-0.3	0.7	-0.3	0.2	0.1	-0.3	-1.0	-0.3	-0.3	-1.1	-0.5	-0.9	-0.1	-0.6	-0.3	-0.5	-0.2
Asthma (self-reported)	0.2	0.5	2.1	0.9	0.0	-0.8	-1.4	-0.2	1.1	-0.9	-0.9	-0.1	-0.3	-0.6	-0.8	-0.4	-0.3	0.5	-0.2	-0.3	0.4	0.7
Myopia	0.2	0.3	1.3	0.6	0.1	-0.6	-0.4	0.0	-0.8	0.1	-0.6	0.4	-0.0	-0.3	-0.1	-0.3	-0.3	1.1	-0.3	-0.3	-0.5	-1.1
Pack years of smoking	0.2	0.3	2.0	-0.2	0.8	1.0	1.4	0.4	-0.2	0.3	0.0	-0.6	0.1	0.3	0.6	0.2	0.2	0.6	0.0	-0.9	-0.2	-0.6
Impedance of whole body	0.2	0.9	2.4	0.8	-1.0	-0.8	1.2	-0.9	0.3	-1.5	-0.1	-0.6	-0.3	-1.6	-1.0	-0.8	-0.7	0.2	-0.4	-1.3	0.6	1.4
Age at First Birth	0.1	0.1	0.4	0.2	0.2	-0.0	0.2	0.2	-0.4	0.7	0.5	-0.2	0.6	0.0	0.4	-0.1	-0.2	0.3	-0.1	0.2	-0.0	-0.0
Triglycerides	0.1	0.2	1.1	-0.3	-0.4	-0.9	-0.3	-0.3	0.6	-0.6	-0.6	-0.2	-0.3	-0.3	-1.0	-0.6	0.2	-0.3	-0.3	0.0	-0.3	-0.6
Blood Eosinophil Count	0.1	0.7	5.2	-0.3	0.7	-0.3	0.4	0.6	-0.4	0.3	0.2	1.2	0.0	1.0	2.3	0.2	-0.1	-0.2	0.5	-1.9	-0.3	-0.4
BMI	0.1	0.7	2.6	-1.6	-0.3	0.1	0.4	-0.5	-1.6	0.9	1.5	0.6	-0.2	1.4	0.3	0.3	-0.1	-1.6	0.5	0.3	-0.5	-0.2
Hypothyroidism (self reported)	0.1	0.2	1.0	-1.0	-0.1	0.4	-0.2	0.1	-0.7	0.5	0.6	0.7	-0.5	0.5	-0.1	0.1	-0.1	-0.4	-0.1	-0.7	-0.5	-0.8
Ever had hysterectomy (womb removed)	0.1	0.1	0.6	-0.7	-0.2	0.2	-0.4	-0.4	0.3	-0.1	0.3	0.2	-0.2	0.2	0.1	-0.1	-0.0	-0.8	-0.0	-0.4	-0.2	0.1
Supplements: Zinc	0.1	0.1	0.4	0.1	0.1	0.1	0.3	0.2	0.6	-0.1	-0.3	-0.4	0.2	0.1	-0.2	0.1	0.3	-0.3	0.3	-0.6	0.3	0.5
Impedance of leg (right)	0.1	0.7	3.5	0.7	-0.9	-0.2	0.3	-0.6	0.2	-1.7	-0.2	-0.5	-0.2	-1.1	-1.0	-0.7	-0.4	-0.5	-0.0	-1.9	0.5	1.3
Hand grip strength (right)	0.1	0.4	1.5	0.3	0.3	0.9	-1.2	0.5	0.6	0.1	0.1	-0.6	0.5	0.2	0.3	0.6	1.1	-0.2	0.2	1.1	0.2	-0.0
Relative age voice broke	0.1	0.2	1.0	-0.2	-0.4	-0.0	-0.3	0.2	-1.0	-0.5	0.2	0.0	-0.1	0.2	0.0	0.2	-0.4	-0.5	0.6	-0.4	0.2	0.7
Weight	0.1	0.6	2.0	-0.8	0.7	1.1	-0.6	0.6	-0.7	1.1	1.4	0.2	0.5	1.1	0.5	0.7	0.1	-0.7	0.6	0.4	-0.2	-0.7
Forced vital capacity (FVC), Best measure	0.1	0.3	1.2	0.8	0.3	1.0	-0.4	0.9	0.2	-0.6	-0.5	0.2	-0.5	0.2	-0.3	0.1	0.5	1.1	0.6	0.7	0.3	-0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.9	-0.1	0.4	-0.8	0.0	0.0	0.2	-0.0	-0.7	-1.0	-0.1	-0.1	-0.1	0.1	-0.3	0.1	-0.4	-0.6	-0.3	-0.5
Neck or shoulder pain in last month	0.1	0.2	1.3	0.1	-0.1	-0.8	0.2	0.1	-0.2	-0.1	-0.4	-0.1	0.1	0.4	0.1	0.5	0.9	-0.4	0.4	1.1	0.1	-0.2
Pulse rate, automated reading	0.1	0.5	2.4	-0.8	0.2	-0.0	1.0	-0.2	0.5	0.9	0.1	0.4	0.4	0.2	-1.5	0.4	0.3	0.3	0.2	0.8	0.6	1.5
Qualifications: nursing, teaching	0.1	0.2	0.6	0.3	0.3	0.3	0.3	0.6	-0.2	0.3	0.3	0.5	0.4	0.8	0.7	0.5	0.5	0.3	0.6	0.7	0.1	-0.1
Guilty feelings	0.1	0.2	0.7	-0.3	-0.1	-0.1	-0.9	-0.2	0.6	-0.6	-0.5	-0.6	0.1	-0.6	0.0	-0.4	-0.1	0.2	-0.3	0.0	-0.1	-0.2
Blood White Count	0.0	0.3	1.3	-0.4	-0.4	-0.6	0.1	-1.1	-0.4	-0.4	0.4	0.3	0.2	-0.6	0.2	-0.5	-0.8	-0.8	-0.3	-0.6	0.0	0.6
Hair Pigment	0.0	0.8	2.7	-0.2	0.6	1.4	-0.2	1.5	-0.4	0.7	1.0	0.5	0.7	1.6	0.6	0.9	1.2	-0.4	1.3	0.8	0.2	0.4
Tanning	0.0	0.2	0.7	-0.7	-0.2	0.3	-0.8	-0.2	-0.3	0.8	0.5	0.3	-0.5	0.5	0.7	0.3	-0.0	-0.8	0.0	0.2	-0.4	-0.2

Hub : Genes

WDR52

Models

Trait associations