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chr3:118,519,294-125,681,401

Best TWAS P=8.01e-12 · Best GWAS P=3.04e-17 conditioned to 1.23e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GOLGB1	0.04	0.02	enet	11	0.02	7.7e-04	-3.6	5.4	8.0e-08	-0.07	0.10	0.68	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SLC12A8	0.38	0.10	lasso	12	0.32	1.9e-39	-3.0	-5.2	2.5e-07	-0.05	0.76	0.22	TRUE
3	CommonMind	Brain Pre-frontal Cortex	TIMMDC1	0.04	0.02	bslmm	504	0.01	2.9e-02	-5.2	-5.2	1.9e-07	0.04	0.03	0.67	TRUE
4	GTEx	Adipose Subcutaneous	LRRC58	0.08	0.03	enet	11	0.05	5.4e-05	5.2	-6.2	4.5e-10	0.01	0.02	0.97	TRUE
5	GTEx	Artery Coronary	IQCB1	0.21	0.14	enet	21	0.10	2.2e-04	5.5	-5.2	2.6e-07	0.06	0.03	0.95	FALSE
6	GTEx	Artery Tibial	EAF2	0.05	0.01	lasso	8	0.02	1.3e-02	5.5	-5.3	9.7e-08	0.06	0.04	0.82	FALSE
7	GTEx	Artery Tibial	ADCY5	0.17	0.03	lasso	6	0.04	8.9e-04	6.3	-6.8	1.3e-11	0.36	0.97	0.02	FALSE
8	GTEx	Artery Tibial	RP11-797D24.4	0.20	0.03	lasso	5	0.05	9.4e-05	6.3	-6.5	9.9e-11	0.37	0.93	0.04	FALSE
9	GTEx	Brain Putamen basal ganglia	IQCB1	0.37	0.26	lasso	9	0.22	5.1e-06	5.5	-5.4	8.2e-08	0.04	0.03	0.95	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	EAF2	0.22	0.18	lasso	13	0.15	1.0e-05	5.5	-5.2	1.7e-07	0.05	0.03	0.96	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	IQCB1	0.32	0.29	lasso	14	0.27	1.7e-09	5.5	-5.5	5.1e-08	0.05	0.03	0.97	FALSE
12	GTEx	Colon Sigmoid	SEC22A	0.16	0.12	lasso	3	0.11	1.2e-04	5.0	-5.2	2.5e-07	0.14	0.37	0.04	FALSE
13	GTEx	Colon Transverse	SEC22A	0.18	0.11	enet	19	0.14	2.8e-07	5.0	-5.3	1.0e-07	0.18	1.00	0.00	FALSE
14	GTEx	Esophagus Mucosa	SEC22A	0.22	0.31	lasso	17	0.30	1.3e-20	5.0	-5.3	1.2e-07	0.16	1.00	0.00	FALSE
15	GTEx	Liver	SEC22A	0.21	-0.01	lasso	5	0.00	2.3e-01	5.0	-5.8	6.1e-09	0.14	0.10	0.12	FALSE
16	GTEx	Lung	RP11-797D24.4	0.08	0.01	enet	10	0.03	4.1e-03	6.4	-6.8	8.0e-12	0.50	0.22	0.50	TRUE
17	GTEx	Small Intestine Terminal Ileum	IQCB1	0.28	0.18	lasso	14	0.18	7.4e-05	5.5	-5.6	1.7e-08	0.04	0.03	0.90	FALSE
18	GTEx	Stomach	SEC22A	0.14	0.07	enet	24	0.04	4.7e-03	5.0	-5.2	1.9e-07	0.16	0.77	0.01	FALSE
19	GTEx	Thyroid	IQCB1	0.25	0.24	lasso	5	0.27	1.1e-20	5.5	-5.3	9.8e-08	0.04	0.02	0.98	FALSE
20	METSIM	Adipose	ITGB5	0.05	0.04	lasso	3	0.04	2.2e-06	-5.1	5.3	1.1e-07	0.00	0.02	0.98	TRUE
21	NTR	Blood	EAF2	0.02	0.02	lasso	3	0.02	2.3e-06	5.5	5.7	1.3e-08	-0.06	0.03	0.97	TRUE
22	YFS	Blood	PARP9	0.06	0.02	enet	21	0.03	2.0e-09	4.1	-5.1	3.0e-07	0.00	0.17	0.60	TRUE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD80	0.02	0.01	blup	86	0.01	6.0e-03	-3.4	5.3	1.3e-07	0.04	0.04	0.16	TRUE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEC22A	0.01	0.01	blup	76	0.01	2.4e-02	5.0	-5.3	9.2e-08	0.18	0.44	0.02	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEC22A	0.04	0.01	blup	76	0.04	2.1e-05	-4.3	-5.5	3.6e-08	0.27	0.48	0.39	FALSE