Hub : Genes

SLC9A9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0451	0.0183	0.0054	0.005	0.014	0.011	0.013	0.003	0.0500	0.0030	0.0067	0.0041	0.09000
2	YFS	Blood	0.0293	0.0120	0.0073	0.003	0.004	0.001	0.008	0.011	0.0360	0.0140	0.1300	0.0009	0.00011
3	TCGA	Stomach Adenocarcinoma	0.1400	0.0520	0.0015	0.030	0.024	0.010	NA	0.023	0.0028	0.0073	0.0540	NA	0.00790

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.0	1.6	2.1	-1.2	-1.5	-1.1
Bipolar Disorder or Schizophrenia	0.5	1.3	2.1	-1.1	-1.4	-0.7
Depressed Affect (Nagel 2018)	0.1	0.3	0.6	0.2	0.8	-0.4
Depression (Nagel 2018)	1.0	1.5	2.4	-1.5	1.4	-0.0
Intelligence (Savage-Jansen 2018)	0.8	2.6	6.4	2.5	-0.8	-0.9
Neuroticism (Nagel 2018)	0.2	0.4	0.8	0.9	0.0	-0.7
Schizophrenia (2018)	0.1	0.2	0.4	-0.4	-0.7	-0.1
Schizophrenia vs Biploar Disorder	1.8	2.3	4.0	1.6	0.5	2.0
Worry (Nagel 2018)	0.3	0.7	1.6	0.3	-1.3	-0.5
Alzheimer’s Disease (in mother)	1.8	2.2	4.2	-2.1	1.5	0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.5	-0.1	-0.4
Alzheimer’s Disease (including proxy)	1.7	2.5	4.8	-2.2	1.4	0.8
Crohns Disease (2017)	0.4	0.8	1.1	1.0	-0.6	1.0
Irritable Bowel Disease (IBD)	0.6	1.4	2.4	1.2	0.3	1.6
Ulcerative Colitis (UC)	0.9	1.8	2.7	1.6	0.7	1.5
Major Depression (MDD)	0.7	0.9	2.1	0.4	-0.6	-1.4
Reaction Time	0.3	0.6	0.8	-0.8	-0.9	0.5
Verbal and Numeric Reasoning (VNR)	0.8	2.0	3.3	1.8	-0.5	-1.5
Breast Cancer	0.3	0.7	2.0	0.4	-1.4	0.2
Ovarian Cancer	1.0	1.4	2.9	-0.0	-1.7	1.1
Prostate Cancer	0.5	0.7	1.8	-1.3	0.4	0.4
Age at First Birth	0.4	0.5	0.8	0.8	-0.9	0.5
Bipolar Disorder (2011)	0.6	0.6	1.4	-0.7	0.0	-1.2
Body Mass Index (BMI) (2010)	1.0	1.4	3.4	0.9	-0.1	-1.8
Coronary Artery Disease (CAD)	0.2	0.2	0.7	-0.1	0.8	0.1
Crohns Disease (2012)	0.4	0.7	0.9	-0.9	-0.6	1.0
Mean Putamen Volume	0.2	0.2	0.5	-0.7	-0.0	-0.4
Fasting Glucose	0.5	0.6	1.7	0.3	0.2	-1.3
HbA1C	0.6	0.7	1.0	-0.5	-0.9	1.0
HDL Cholesterol	0.6	0.9	2.7	-0.1	-0.4	1.6
LDL Cholesterol	0.3	0.5	0.7	0.7	0.4	-0.8
Lupus	3.3	5.0	13.8	-0.3	0.9	-3.7
Neuroticism (2016)	0.4	0.5	0.9	0.4	0.7	-0.9
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.0	0.8	0.4
Rheumatoid Arthritis	1.8	2.5	6.3	-0.7	-2.5	0.9
Schizophrenia (2014)	0.1	0.1	0.2	-0.4	-0.2	0.4
Triglycerides	1.0	1.6	4.2	-0.4	-0.7	-2.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	0.3	0.6	0.2
Ulcerative Colitis	0.4	0.6	1.2	0.1	-0.7	1.1
Blood Eosinophil Count	0.0	0.2	0.2	0.2	0.5	0.5
Blood Platelet Count	0.2	2.8	5.2	-0.5	2.3	-1.8
Blood Red Count	0.8	7.5	19.5	1.7	-4.4	-0.2
Blood White Count	0.0	0.2	0.5	-0.2	-0.7	-0.1
Heel T-Score	0.2	1.9	4.0	-0.7	2.0	-1.1
BMI	0.7	4.0	10.2	-3.2	-0.3	-1.3
Height	0.9	17.4	49.6	7.0	-0.0	1.6
Waist Hip Ratio (WHR)	0.2	0.8	1.3	0.4	-1.0	1.1
Systolic Blood Pressure	0.1	0.7	1.7	-0.2	-1.3	-0.6
Smoking Status	0.5	1.2	1.5	1.2	0.9	-1.1
Allergy or Eczema	0.5	1.4	3.5	-1.9	0.6	-0.4
Cardiovascular Disease	0.4	1.4	2.8	-0.1	-1.2	-1.7
Hypothyroidism (self reported)	0.1	0.2	0.4	-0.2	0.6	0.5
Respiratory disease	0.2	0.4	0.8	-0.7	-0.0	-0.9
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.6	0.3	-0.6
Lung FEV1/FVC ratio	0.5	2.7	5.6	-2.4	-1.6	0.2
Lung FVC	0.3	1.7	5.0	2.2	0.3	-0.0
Neuroticism	0.5	1.2	2.9	0.6	0.6	-1.7
Chronotype (morning person)	0.1	0.3	0.4	0.3	-0.5	0.6
Hair Pigment	0.0	1.1	2.5	1.6	0.9	0.2
Tanning	0.1	0.7	1.4	0.9	0.1	1.2
Hand grip strength (left)	0.4	0.9	1.0	1.0	-0.9	1.0
Number of treatments/medications taken	0.1	0.1	0.1	0.2	0.4	-0.4
Average weekly spirits intake	0.6	0.8	1.9	-0.7	-1.4	-0.1
Sensitivity / hurt feelings	0.4	0.7	1.1	0.8	1.0	-0.5
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.3	-1.8	1.2	-0.7
Hearing difficulty/problems: Yes	0.2	0.4	0.8	-0.5	0.3	0.9
Relative age of first facial hair	2.2	4.6	11.9	1.1	3.5	-0.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.8	0.1	0.8	1.3
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.6	-0.0	1.6	0.5
Ever had hysterectomy (womb removed)	0.8	0.9	1.5	-1.2	1.0	-0.2
Systolic blood pressure, automated reading	0.7	2.1	3.8	-1.9	-0.8	-1.3
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	4.2	0.4	2.0	-0.8
Angina	0.7	1.0	1.5	0.8	-1.2	-0.9
Medication for hormone replacement therapy	1.5	1.7	2.3	-1.1	1.5	1.2
Vitamin and mineral supplements	0.7	1.0	1.8	1.4	-1.1	-0.3
Supplements: Zinc	0.1	0.1	0.3	-0.5	-0.3	-0.2
Medication: Co-codamol	4.2	4.9	10.9	-1.4	-3.3	1.3
Medication: Metformin	1.1	1.5	3.5	0.3	1.9	-1.0
Diabetes (father)	1.0	1.3	3.2	-1.8	-0.8	0.3
Diabetes (mother)	0.7	0.9	2.7	0.1	-1.6	0.2
Severe depression (siblings)	0.8	0.9	1.6	0.6	1.3	0.9
Pack years adult smoking proportion	1.0	1.6	4.3	0.6	2.1	-0.1
Impedance of leg (right)	0.3	1.4	2.8	0.9	-0.9	-1.7
Leg fat-free mass (left)	0.2	1.2	3.0	0.7	-0.4	1.7
Trunk fat percentage	0.5	2.1	3.1	-1.8	-1.1	-1.4
Hand grip strength (right)	0.5	1.5	1.8	0.9	-1.3	1.4
Townsend deprivation index at recruitment	1.0	1.3	3.8	0.5	0.1	1.9
Current tobacco smoking	1.0	1.7	2.7	1.6	1.2	1.0
Average weekly fortified wine intake	2.0	2.4	3.7	1.9	0.3	-1.8
Maternal smoking around birth	1.6	2.3	5.6	0.6	2.4	1.0
Fed-up feelings	0.0	0.1	0.1	-0.3	0.2	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.2	0.1	0.7	2.0
Relative age voice broke	1.0	1.6	4.3	0.3	2.1	-0.6
Taking other prescription medications	0.6	0.9	2.4	0.4	1.6	-0.2
Age when periods started (menarche)	0.0	0.1	0.2	-0.3	-0.4	-0.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.6	-1.6	0.1	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.3	-0.1	0.0	0.6
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.7	1.3	-0.9	-0.1
Qualifications: CSEs or equivalent	0.5	0.6	1.3	-1.1	-0.4	-0.7
Serious illness, injury or assault to yourself	0.7	0.9	1.8	0.4	1.4	0.8
High blood pressure	0.6	1.8	2.5	-1.1	-1.3	-1.6
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.8	-2.2	0.5	-0.1
Multivitamins +/- minerals	1.1	1.3	3.1	-0.2	0.9	1.8
Stomach or abdominal pain in last month	0.4	0.5	0.7	-0.7	-0.3	-0.9
Supplements: Glucosamine	1.0	1.4	2.5	-1.3	-0.0	1.6
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	5.4	1.9	-0.7	-2.3
Medication: Atenolol	1.0	1.3	2.7	0.9	0.5	-1.6
Medication: Levothyroxine sodium	0.5	0.8	2.2	-0.2	-0.4	1.5
Sitting height	0.6	4.6	12.1	3.5	-0.6	1.1
Chronic bronchitis/emphysema (father)	0.4	0.5	0.8	-0.9	0.7	0.4
High blood pressure (mother)	0.2	0.2	0.6	-0.1	-0.3	0.8
Body mass index (BMI)	0.7	2.9	7.8	-2.8	-0.9	-0.2
Impedance of leg (left)	0.4	2.0	5.2	0.6	-0.7	-2.3
Leg predicted mass (left)	0.2	1.3	3.1	0.7	-0.5	1.8
Trunk fat mass	0.3	1.1	1.4	-1.2	-1.1	-0.8
Waist circumference	0.6	2.3	4.0	-2.0	-1.6	0.6
Number of incorrect matches in round	0.7	1.2	2.7	-1.6	-0.6	0.6
Past tobacco smoking	0.8	1.4	3.0	-0.9	-0.7	1.7
Alcohol usually taken with meals	0.8	1.3	1.9	-1.4	-1.4	0.2
Nervous feelings	0.7	1.4	4.1	-0.0	-2.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	2.0	-1.4	1.0	-0.7
Hearing difficulty/problems with background noise	0.6	1.0	1.8	-0.4	1.0	1.4
Hair/balding pattern: Pattern 2	0.6	0.8	1.2	-1.1	0.6	-1.0
Had menopause	0.6	0.8	2.2	-1.5	0.3	0.1
Had other major operations	0.1	0.1	0.2	-0.4	-0.3	0.0
Forced vital capacity (FVC)	1.5	5.7	16.1	4.0	0.1	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.4	0.1	0.6	0.6
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	4.3	-2.1	-0.5	1.2
Qualifications: None of the above	0.4	0.9	1.6	-0.2	-1.3	-1.1
Financial difficulties in last 2 years	0.4	0.5	1.2	-1.1	0.5	-0.2
Mouth/teeth dental problems	1.0	1.5	3.2	1.1	-0.2	1.8
Heart attack	1.4	1.8	2.6	1.4	-0.9	-1.6
Allergy	0.4	0.8	2.5	1.6	-0.2	-0.0
Pain all over the body in last month	0.9	1.0	1.4	1.1	-0.5	-1.2
Diabetes (self-reported)	0.5	0.7	1.6	-0.1	1.3	-0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	-0.8	0.1	0.3
Medication: Ramipril	0.1	0.2	0.4	0.0	-0.6	-0.3
Medication: Simvastatin	0.2	0.3	0.7	0.4	-0.5	-0.8
Fluid intelligence score	1.1	2.4	4.7	1.3	-0.8	-2.2
Illnesses of siblings	0.3	0.5	0.9	0.6	-0.3	0.9
Neuroticism score	0.5	1.0	2.1	1.0	-0.1	-1.5
Weight	0.1	0.5	1.2	-0.5	-1.1	0.4
Impedance of arm (right)	0.4	2.1	5.4	2.3	0.3	-0.9
Arm fat percentage (right)	0.6	2.4	5.2	-2.3	-0.8	-1.2
Trunk fat-free mass	0.4	2.2	4.0	1.6	-0.1	2.0
Hip circumference	0.3	1.2	3.0	-1.7	-0.8	0.1
Time employed in main current job	0.9	1.0	2.2	-0.9	-0.2	-1.5
Alcohol intake versus 10 years previously	0.6	0.9	2.6	-0.2	-1.6	0.1
Father’s age at death	2.3	3.0	5.7	-1.6	-2.4	-0.9
Worrier / anxious feelings	0.4	0.7	1.1	1.0	-1.0	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	0.1	-0.1	0.7
Falls in the last year	0.1	0.2	0.3	-0.5	0.5	-0.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.2	-0.7	0.3
Number of live births	1.2	1.7	3.6	1.2	1.9	0.0
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	8.4	2.9	-0.9	1.0
Pulse rate	0.7	1.1	1.8	-0.3	-1.3	-1.2
Happiness	0.2	0.3	0.5	0.4	-0.4	0.7
Noisy workplace	0.9	1.1	3.1	-0.4	0.2	1.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.0	0.4	1.0	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	5.4	0.1	0.2	-2.3
Mouth/teeth dental problems: Dentures	0.5	0.8	1.0	1.0	-0.6	-1.0
Asthma	0.0	0.1	0.2	0.5	0.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	5.9	-1.7	1.0	2.4
Medication: Cholesterol lowering	0.1	0.2	0.5	0.2	-0.2	-0.7
Depression (self-reported)	2.1	2.5	5.9	-1.2	-0.3	-2.4
Medication: Lansoprazole	0.2	0.2	0.5	0.3	0.2	-0.7
Prospective memory result	0.2	0.3	0.6	0.5	-0.2	0.8
Lung cancer (father)	1.9	2.2	3.7	1.7	0.2	1.9
Illnesses of mother	1.8	2.2	6.1	2.5	0.2	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	5.8	2.4	0.5	1.0
Pulse wave Arterial Stiffness index	2.7	3.2	5.7	-1.9	-0.7	2.4
Impedance of arm (left)	0.5	2.5	6.6	2.6	0.1	-0.9
Arm fat mass (right)	0.3	1.4	3.0	-1.7	-0.9	-0.6
Trunk predicted mass	0.4	2.4	4.3	1.7	-0.2	2.1
Standing height	0.9	8.8	24.3	4.9	-0.1	1.4
Length of working week for main job	3.5	3.9	11.5	-0.4	0.0	3.4
Exposure to tobacco smoke at home	1.2	1.4	2.3	-1.0	0.9	-1.5
Breastfed as a baby	2.3	2.9	6.4	-0.2	-1.4	-2.5
Tense / ‘highly strung’	0.8	1.3	3.0	0.9	0.3	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	5.4	-1.6	-2.3	0.4
Hair/balding pattern: Pattern 4	0.4	1.0	2.5	-0.3	-0.5	1.6
Birth weight of first child	1.4	2.6	4.3	1.7	-0.8	2.1
Peak expiratory flow (PEF)	2.1	5.0	13.3	3.6	-1.0	0.8
Pulse wave reflection index	0.5	0.6	1.0	-1.0	0.3	0.9
Ever highly irritable/argumentative for 2 days	1.2	1.5	4.1	-0.2	0.5	2.0
Loud music exposure frequency	1.0	1.1	2.2	-0.3	1.0	1.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.4	1.0	1.6	-0.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.1	-1.8	-0.3	-0.2
Blood clot in the leg (DVT)	0.6	0.8	1.6	0.6	-0.7	1.2
Medication: Paracetamol	0.3	0.4	0.6	-0.6	0.8	0.5
Headache pain in last month	0.9	1.5	2.4	-1.5	-1.5	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	-0.4	0.6	0.1
Glaucoma (self-reported)	3.5	4.1	8.4	-2.9	-0.2	1.9
Gout (self-reported)	0.6	0.9	1.8	-1.3	0.3	-0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.8	0.0	-0.3	0.9
Medication: Amlodipine	0.3	0.4	1.0	0.4	0.4	1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.9	-0.0	0.7	1.0
Birth weight	3.4	7.3	21.2	4.6	0.9	0.2
Chronic bronchitis/emphysema (mother)	3.6	4.2	8.0	-2.0	0.9	2.8
High blood pressure (siblings)	0.5	0.7	1.8	0.1	0.6	-1.3
Forced vital capacity (FVC), Best measure	1.5	5.4	13.4	3.7	1.4	0.9
Body fat percentage	0.8	3.3	5.2	-2.3	-1.5	-1.6
Leg fat percentage (right)	1.0	3.7	7.0	-2.6	-1.7	-1.2
Arm fat-free mass (right)	0.1	0.6	1.2	0.6	-0.6	1.1
Exposure to tobacco smoke outside home	0.8	1.1	2.1	1.0	0.3	-1.4
Comparative body size at age 10	0.2	0.6	1.5	1.2	-0.1	-0.5
Number of full brothers	0.9	1.1	2.5	-1.6	0.6	0.7
Worry too long after embarrassment	0.8	1.4	2.2	0.8	-1.5	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.3	-2.1	-0.9	0.4
Wheeze or whistling in the chest in last year	1.0	1.8	4.1	-0.6	2.0	-0.9
Number of children fathered	0.4	0.4	0.7	0.3	-0.9	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.5	0.4	-1.6	0.1
Age at first live birth	1.2	2.2	4.8	-1.1	-0.6	-2.2
Pulse wave peak to peak time	2.4	2.8	4.0	2.0	0.7	-2.0
Health satisfaction	1.2	1.6	3.5	0.1	-1.9	1.2
Shortness of breath walking on level ground	1.9	2.3	3.4	1.8	-0.1	1.9
Qualifications: College or University degree	0.7	2.2	4.8	0.3	2.2	1.3
Eye problems/disorders: None of the above	1.1	1.3	3.1	1.8	-0.6	-0.5
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.4	-1.8	0.1	-1.0
Emphysema/chronic bronchitis	0.9	1.0	1.7	-1.3	-0.9	0.7
Medication for pain relief, constipation, heartburn	1.2	2.0	4.3	1.0	-0.8	-2.1
Neck or shoulder pain in last month	0.7	1.0	2.8	-1.7	0.1	-0.3
Medication: Blood pressure	0.3	0.5	1.1	0.1	-1.0	0.5
Angina (self-reported)	0.7	0.9	1.7	0.4	-1.3	-0.8
Migraine (self-reported)	0.5	0.7	1.6	1.2	0.5	-0.4
Medication: Ibuprofen	2.1	2.6	4.7	-1.7	0.5	2.2
Medication: Allopurinol	0.2	0.3	0.7	-0.5	0.1	-0.8
Medication: Omeprazole	1.2	1.4	3.1	-0.5	-1.8	0.9
Medication: Seretide 50 evohaler	0.5	0.5	0.8	0.9	0.1	-0.9
Mean time to correctly identify matches	0.1	0.3	0.4	-0.6	-0.5	0.5
Heart disease (mother)	1.3	1.5	2.1	-1.5	-1.4	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.5	1.2	0.8	0.8
Whole body fat mass	0.4	1.7	2.5	-1.6	-1.1	-1.1
Leg fat mass (right)	0.6	2.3	4.5	-2.1	-1.3	-0.9
Arm predicted mass (right)	0.1	0.7	1.1	0.5	-0.9	1.1
Pulse rate, automated reading	0.7	2.1	3.6	0.1	-1.9	-1.7
Alcohol intake frequency.	0.2	0.5	0.8	0.9	-0.9	0.1
Comparative height size at age 10	1.1	6.2	12.1	3.5	-1.9	1.6
Number of full sisters	0.2	0.2	0.2	-0.5	-0.4	0.5
Suffer from ‘nerves’	1.3	2.0	5.0	-0.1	-2.2	-1.0
Overall health rating	0.5	1.0	3.0	-1.7	-0.2	0.3
Chest pain or discomfort	0.3	0.4	0.8	0.1	-0.7	0.9
Had major operations	1.3	1.5	3.9	0.7	2.0	0.2
Age at last live birth	1.4	2.0	5.1	0.1	0.9	-2.3
Family relationship satisfaction	0.5	0.6	1.2	1.1	-0.7	-0.3
Leg pain on walking	1.1	1.4	3.2	0.8	-0.5	1.8
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.1	-1.4	-1.0	0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.0	0.5	1.0	-0.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.9	0.9	-0.5	-0.1
Medication: Aspirin	0.1	0.1	0.3	-0.0	0.2	-0.6
Supplements: Vitamin C	1.8	2.2	4.3	-1.4	0.5	-2.1
Knee pain experienced in last month	1.0	1.6	2.3	-1.3	1.5	1.0
Hypertension (Self-reported)	0.4	1.1	1.3	-1.0	-1.0	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.8	-2.0	-0.3	-0.7
Illnesses of father: Heart disease	0.6	0.8	1.6	0.5	1.2	-0.8
Illnesses of siblings: Diabetes	1.4	1.8	4.1	-1.0	0.5	-2.0
Smoking status: Previous	0.4	0.6	1.9	0.1	0.1	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.7	12.5	3.5	1.2	0.5
Whole body fat-free mass	0.3	1.6	3.3	1.1	-0.3	1.8
Leg fat-free mass (right)	0.2	1.1	2.9	0.6	-0.2	1.7
Arm fat percentage (left)	0.6	2.3	4.4	-2.1	-0.7	-1.4
Average weekly red wine intake	0.4	0.6	1.0	-0.9	0.2	-1.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.6	-1.6	0.8	-0.2
Mood swings	0.5	1.0	1.6	-1.3	-1.0	-0.6
Loneliness, isolation	0.7	1.0	2.7	-0.4	0.0	1.6
Long-standing illness, disability or infirmity	0.9	1.4	2.5	-1.0	1.6	-0.8
Ever had bowel cancer screening	0.2	0.3	0.8	-0.9	0.0	0.3
Diabetes diagnosed by doctor	0.7	1.1	2.9	0.3	1.7	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	8.5	-2.9	0.1	0.4
Friendships satisfaction	0.5	0.6	1.5	1.2	-0.5	0.2
Qualifications: nursing, teaching	0.0	0.1	0.1	0.3	0.2	-0.1
Commuting to job workplace: Walk	1.2	1.2	2.3	-1.5	-0.1	-1.2
Eye problems/disorders: Cataract	1.9	2.2	6.1	-2.5	-0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.8	-1.9	-0.2	-1.4
Medication for cholesterol	0.3	0.4	0.6	0.5	-0.8	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.1	1.1	-0.5	-1.1
Back pain experienced in last month	0.3	0.4	1.0	-1.0	0.3	0.3
Mineral and other dietary supplements	0.6	0.8	1.6	-1.0	-0.0	-1.3
Breast cancer (self-reported)	0.4	0.5	1.2	-0.4	1.1	-0.3
Asthma (self-reported)	0.1	0.1	0.2	0.5	0.2	-0.2
Osteoporosis (self-reported)	1.0	1.3	2.3	1.2	0.1	-1.5
Osteoarthritis (self-reported)	0.2	0.3	0.5	0.5	0.1	0.7
Medication: Aspirin	0.0	0.0	0.1	-0.0	0.1	0.3
Medication: Gliclazide	2.8	3.2	7.7	-0.6	2.8	-1.2
Illnesses of father: None of the above (group 1)	0.6	0.8	1.3	1.1	-0.8	0.6
Smoking status: Current	0.9	1.4	2.6	1.6	1.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	0.4	-0.7	-0.1
Whole body water mass	0.3	1.4	3.0	1.1	-0.3	1.7
Leg predicted mass (right)	0.2	1.2	2.8	0.8	-0.2	1.7
Arm fat mass (left)	0.3	1.3	2.9	-1.7	-0.8	-0.8
Number of self-reported non-cancer illnesses	0.7	1.3	3.1	-1.8	-0.6	-0.6
Average weekly champagne plus white wine intake	0.6	0.9	1.4	-0.6	0.9	1.2
Miserableness	0.2	0.3	0.8	0.9	0.2	0.4
Guilty feelings	0.5	0.7	1.5	-0.1	0.8	-1.2
Wears glasses or contact lenses	1.6	1.8	3.5	-0.6	1.2	-1.9
Ever taken oral contraceptive pill	0.1	0.2	0.4	-0.7	0.1	0.2
Hearing aid user	0.7	0.8	1.8	0.6	-1.3	-0.6
Mother’s age at death	0.7	0.8	2.2	-1.5	0.0	-0.5
Financial situation satisfaction	0.5	0.7	0.8	0.8	-0.9	0.7
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.4	-0.0	1.6	-0.9
Commuting to job workplace: Public transport	0.7	0.8	1.9	-0.1	-0.7	-1.4
Eye problems/disorders: Glaucoma	2.6	3.0	4.6	-2.1	-0.9	1.9
Medication: Blood pressure	0.4	0.9	2.4	-0.4	-0.1	-1.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.7	0.1	-0.1	-1.6
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.2	-0.1	-0.7	1.1
High cholesterol (Self-reported)	0.2	0.4	0.9	-0.3	0.3	-0.9
Medication: Bendroflumethiazide	0.5	0.8	1.5	-0.5	-1.2	-0.7
Medication: Paracetamol	0.3	0.4	0.6	-0.8	0.4	0.7
Medication: Lisinopril	0.4	0.5	1.1	-0.1	-0.7	-1.0
Medication: Atorvastatin	0.1	0.1	0.2	-0.5	0.2	0.3
Illnesses of father: High blood pressure	0.7	0.9	1.5	-1.1	1.2	0.0
Alcohol drinker status: Never	2.0	2.4	6.9	0.5	0.0	-2.6
Ever smoked	0.7	1.3	1.9	0.5	1.3	-1.4
Basal metabolic rate	0.2	1.0	2.2	0.8	-0.4	1.5
Leg fat percentage (left)	1.2	4.5	7.8	-2.8	-1.7	-1.6
Arm fat-free mass (left)	0.1	0.7	1.7	0.3	-0.5	1.3
Number of operations (self-reported)	0.7	1.1	2.9	-0.0	1.7	-0.6
Average weekly beer plus cider intake	2.4	3.5	3.8	1.9	1.8	-1.8
Irritability	0.2	0.4	1.0	0.0	-1.0	0.4
Risk taking	1.9	2.8	5.2	2.3	1.7	0.5
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.2	-1.1	0.3	-0.2
Fractured/broken bones in last 5 years	1.6	2.0	4.0	-1.1	2.0	-0.9
Age started oral contraceptive pill	0.0	0.0	0.1	-0.1	0.1	-0.3
Diastolic blood pressure, automated reading	0.5	1.6	3.4	-0.6	-1.1	-1.8
Ever depressed for a whole week	1.2	1.5	2.7	-1.6	-0.3	1.3
Unable to work because of sickness or disability	0.3	0.4	0.7	-0.4	0.8	0.7
Commuting to job workplace: Cycle	0.3	0.4	0.4	0.7	-0.6	0.7
Myopia	0.2	0.3	0.8	-0.9	0.3	-0.1
Vascular/heart problems diagnosed by doctor	1.2	3.4	5.7	0.2	2.1	2.4
Cholesterol lowering medication	0.6	0.9	1.9	-0.4	-0.8	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	2.6	-1.6	-1.2	0.7
Pain experienced in last month	1.3	2.1	4.7	1.0	0.7	2.2
Supplements: Calcium	1.4	1.5	2.7	-0.1	-1.6	-1.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.1	0.3	-0.8	-1.1
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.1	1.2	-0.8	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.7	0.8	-0.3	1.3
Heart disease (siblings)	0.7	0.9	2.6	-1.6	0.1	0.0
Alcohol drinker status: Previous	1.3	1.5	2.2	1.5	-1.1	-1.1
Pack years of smoking	0.6	0.9	2.6	0.2	1.6	-0.1
Impedance of whole body	0.4	1.8	2.7	1.6	-0.2	-1.6
Leg fat mass (left)	0.6	2.4	4.7	-2.2	-1.2	-1.0
Arm predicted mass (left)	0.1	0.7	1.9	0.3	-0.4	1.4