Hub : Genes

ATP1B3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0910	0.0300	1.6e-04	0.035	0.019	0.045	0.037	0.047	3.6e-05	1.8e-03	3.1e-06	2.1e-05	2.1e-06
2	GTEx	Cells Transformed fibroblasts	0.1210	0.0400	2.3e-04	0.117	NA	0.060	NA	0.078	4.4e-09	NA	2.7e-05	NA	1.8e-06
3	GTEx	Muscle Skeletal	0.1060	0.0396	2.0e-03	0.017	NA	0.027	NA	0.018	7.7e-03	NA	1.1e-03	NA	5.8e-03
4	YFS	Blood	0.0460	0.0146	1.2e-06	0.025	0.017	0.029	0.019	0.021	1.0e-08	2.7e-06	8.3e-10	3.8e-07	1.1e-07
5	TCGA	Brain Lower Grade Glioma	0.0515	0.0226	1.4e-04	0.030	0.035	0.036	NA	0.037	2.2e-04	6.9e-05	5.6e-05	NA	4.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	4.0	6.3	14.5	1.3	-2.9	-1.6	-2.1	-3.8
Bipolar Disorder or Schizophrenia	1.4	3.3	8.5	2.2	-1.4	0.5	-1.0	-2.9
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	0.5	0.5	-0.1	0.2	-0.1
Depression (Nagel 2018)	0.1	0.1	0.3	0.2	0.1	0.1	-0.6	-0.2
Intelligence (Savage-Jansen 2018)	0.7	2.1	4.2	-0.1	-1.9	-1.5	-0.2	-2.0
Neuroticism (Nagel 2018)	0.1	0.1	0.5	0.7	0.3	-0.0	0.1	-0.2
Schizophrenia (2018)	0.8	1.6	3.8	1.8	0.5	2.0	0.4	-0.8
Schizophrenia vs Biploar Disorder	2.8	3.6	7.0	-0.4	1.9	2.7	1.0	2.5
Worry (Nagel 2018)	0.1	0.2	0.4	-0.3	0.6	0.3	0.4	0.4
Alzheimer’s Disease (in mother)	1.4	1.6	5.6	0.7	0.0	-2.4	1.3	-0.4
Alzheimer’s Disease (in father)	1.1	1.2	3.3	-1.8	-0.5	-1.2	0.8	0.4
Alzheimer’s Disease (including proxy)	0.8	1.2	4.6	-0.1	-0.5	-2.1	0.8	-0.6
Crohns Disease (2017)	0.3	0.7	2.5	-0.5	0.2	-0.8	-0.3	1.6
Irritable Bowel Disease (IBD)	0.9	2.2	3.9	1.2	1.7	-0.2	2.0	1.7
Ulcerative Colitis (UC)	3.1	5.8	13.1	2.4	2.8	0.5	3.6	1.5
Major Depression (MDD)	0.6	0.7	2.6	1.6	0.7	0.0	-0.0	-0.5
Reaction Time	0.7	1.2	5.0	-0.3	0.8	2.2	-0.2	0.7
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.8	-0.6	-1.7	-0.7	-1.2	-1.4
Breast Cancer	0.9	2.2	5.2	-1.5	1.2	2.3	1.2	0.9
Ovarian Cancer	1.3	1.7	3.3	0.5	-1.6	-0.5	-1.4	-1.8
Prostate Cancer	0.4	0.6	1.6	-0.5	-0.5	-1.3	-0.5	-0.9
Age at First Birth	0.1	0.1	0.4	-0.4	0.3	0.6	0.3	0.1
Bipolar Disorder (2011)	1.4	1.4	2.8	0.9	-1.7	0.8	-1.6	0.0
Body Mass Index (BMI) (2010)	1.9	2.7	10.5	-1.0	-0.4	-3.2	-0.3	1.2
Coronary Artery Disease (CAD)	2.8	3.3	10.8	-0.5	1.9	0.9	0.9	3.3
Crohns Disease (2012)	0.7	1.1	1.8	-1.3	-1.0	-1.2	-1.1	0.0
Mean Putamen Volume	1.2	1.4	4.9	-0.2	-1.1	2.2	-0.9	-0.4
Fasting Glucose	0.9	1.1	2.6	1.4	-0.9	0.6	-0.1	-1.6
HbA1C	0.3	0.3	0.7	0.3	0.1	-0.8	0.9	-0.2
HDL Cholesterol	0.4	0.7	2.2	-0.2	1.5	0.9	0.5	0.6
LDL Cholesterol	0.4	0.6	1.3	-0.2	0.4	1.1	1.0	0.7
Lupus	1.0	1.6	2.8	0.5	1.2	-1.1	1.7	1.5
Neuroticism (2016)	1.2	1.8	3.9	0.0	-1.4	0.1	-1.8	-2.0
Primary Biliary Cirrhosis	1.5	2.1	5.0	0.9	-0.3	2.2	-2.1	-0.5
Rheumatoid Arthritis	0.9	1.3	5.0	0.2	0.5	-2.2	1.1	-0.0
Schizophrenia (2014)	0.4	0.8	1.3	0.8	-1.0	0.9	-0.6	-1.2
Triglycerides	1.3	2.1	5.7	0.4	2.0	0.5	0.7	2.4
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.2	1.3	1.5	0.9	1.2	0.7
Ulcerative Colitis	1.3	1.9	5.0	1.9	1.0	-0.2	2.2	0.0
Blood Eosinophil Count	0.3	2.4	7.2	2.7	1.1	-1.1	1.5	0.3
Blood Platelet Count	0.1	0.9	2.9	1.7	0.6	1.0	-0.4	-0.4
Blood Red Count	0.5	4.9	8.1	2.2	2.2	-2.8	1.9	1.8
Blood White Count	1.0	7.6	15.9	3.1	-2.8	-0.7	-2.0	-4.0
Heel T-Score	0.3	2.7	5.7	-2.4	-0.4	2.2	-1.2	1.0
BMI	0.8	4.4	8.9	1.7	3.0	-1.4	-0.5	2.9
Height	1.8	34.8	110.2	6.8	0.3	-10.5	-2.2	-3.5
Waist Hip Ratio (WHR)	1.1	4.8	12.9	-1.9	0.7	3.6	1.0	2.4
Systolic Blood Pressure	0.5	2.3	9.1	-3.0	-1.3	-0.5	0.1	0.9
Smoking Status	1.3	3.1	8.2	0.3	-2.9	0.1	-1.3	-2.3
Allergy or Eczema	1.0	2.7	8.6	-1.6	-1.0	-2.9	-1.1	-0.5
Cardiovascular Disease	0.3	1.1	1.7	-0.6	0.8	-1.0	1.3	1.3
Hypothyroidism (self reported)	2.6	5.9	9.7	-2.0	-3.1	-1.0	-2.8	-2.6
Respiratory disease	0.2	0.5	1.1	0.7	0.7	1.1	-0.6	0.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.3	0.9	-0.5	-1.1	0.1	-0.9
Lung FEV1/FVC ratio	0.6	3.0	6.1	1.1	-1.7	-2.1	0.2	-2.5
Lung FVC	0.3	1.7	6.1	-1.3	-0.8	2.5	0.5	0.2
Neuroticism	0.1	0.2	0.4	0.3	-0.5	-0.4	-0.5	-0.6
Chronotype (morning person)	0.4	0.8	2.1	1.4	0.6	1.3	-0.2	0.3
Hair Pigment	1.3	36.6	52.6	1.8	7.2	-6.4	6.4	6.7
Tanning	0.4	4.4	7.8	2.0	-1.5	2.0	-2.1	-2.8
Hand grip strength (left)	0.4	1.1	3.2	-0.0	0.7	-1.2	1.8	-0.1
Number of treatments/medications taken	0.1	0.2	0.7	-0.8	-0.1	-0.2	0.7	0.3
Average weekly spirits intake	1.9	2.3	6.3	2.5	1.4	1.3	-0.4	-1.3
Sensitivity / hurt feelings	1.0	1.7	3.8	1.9	1.4	-0.3	1.5	0.5
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.0	-0.2	-0.4	0.0	-1.4	-0.6
Hearing difficulty/problems: Yes	0.3	0.5	0.8	0.2	0.9	0.7	-0.8	0.8
Relative age of first facial hair	0.3	0.6	1.3	0.6	-0.8	0.1	-0.8	-1.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.3	0.1	0.6	-1.1	-0.3	0.7
Ever used hormone-replacement therapy (HRT)	1.6	2.0	4.9	-1.1	-1.4	-2.2	-1.1	-0.8
Ever had hysterectomy (womb removed)	1.3	1.5	2.7	-0.2	-1.5	-0.7	-1.6	-1.3
Systolic blood pressure, automated reading	0.5	1.5	3.2	-1.7	-1.8	-0.6	-0.8	-0.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.7	1.0	0.6	1.2	-1.6	0.7
Angina	0.7	0.9	1.7	0.8	1.0	1.3	-1.2	0.1
Medication for hormone replacement therapy	1.5	1.7	4.9	-0.2	-1.4	-2.2	-0.4	-1.2
Vitamin and mineral supplements	2.6	3.5	8.0	2.8	2.5	-0.2	1.4	1.1
Supplements: Zinc	1.1	1.2	4.4	-2.1	-0.8	-0.5	-0.3	-0.8
Medication: Co-codamol	1.4	1.6	4.1	0.8	1.8	0.2	-0.3	2.0
Medication: Metformin	0.8	1.1	2.9	1.4	-0.1	-1.7	0.7	-0.1
Diabetes (father)	2.1	2.7	6.4	-0.7	-2.5	0.3	-1.3	-2.2
Diabetes (mother)	0.7	1.0	2.1	0.6	0.7	-1.4	1.1	0.8
Severe depression (siblings)	1.5	1.7	5.6	-0.3	-1.0	0.1	-2.4	-1.4
Pack years adult smoking proportion	0.2	0.3	0.7	-0.5	-0.1	0.8	-0.8	-0.1
Impedance of leg (right)	0.5	2.5	5.2	1.6	-1.0	0.7	1.9	-2.3
Leg fat-free mass (left)	1.0	5.3	16.7	1.8	1.4	-4.1	-2.2	0.2
Trunk fat percentage	0.8	3.3	7.0	2.6	2.5	-1.2	0.3	1.2
Hand grip strength (right)	1.0	2.8	8.4	1.1	1.6	-0.9	2.9	1.0
Townsend deprivation index at recruitment	0.2	0.3	1.1	-0.2	-0.1	1.0	-0.3	0.6
Current tobacco smoking	0.8	1.3	4.4	-0.5	-2.1	0.5	-0.8	-1.1
Average weekly fortified wine intake	0.3	0.3	0.9	0.5	0.6	-0.9	0.5	0.2
Maternal smoking around birth	1.0	1.5	4.8	-0.4	-0.3	1.4	-2.2	-0.4
Fed-up feelings	0.4	0.8	1.6	0.9	0.3	-1.3	-1.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	-0.6	-0.6	-0.1	-0.6	-0.3
Relative age voice broke	0.2	0.3	0.8	-0.3	-0.8	-0.3	-0.9	-0.2
Taking other prescription medications	0.2	0.3	0.9	-1.0	-0.2	0.1	-0.7	-0.4
Age when periods started (menarche)	0.3	0.8	1.5	-0.6	-0.8	-0.6	-1.2	-1.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	3.8	-0.2	0.2	-1.9	0.1	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	3.7	0.6	1.9	0.2	1.2	1.8
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	1.8	-1.1	1.2	1.4	-0.3	1.1
Qualifications: CSEs or equivalent	0.9	1.2	3.1	0.1	0.7	-0.9	1.8	1.1
Serious illness, injury or assault to yourself	0.3	0.3	0.7	-0.6	0.4	0.4	0.4	0.8
High blood pressure	0.5	1.3	2.9	-0.2	1.7	0.7	0.8	1.6
Hayfever, allergic rhinitis or eczema	0.9	2.0	6.6	-1.3	-1.1	-2.6	-0.5	-0.5
Multivitamins +/- minerals	2.5	3.1	7.9	-2.8	-2.2	0.1	-1.2	-1.2
Stomach or abdominal pain in last month	0.9	1.1	1.8	-1.3	0.0	-0.4	1.3	1.3
Supplements: Glucosamine	0.4	0.5	1.2	-1.1	-0.6	-0.5	0.7	0.4
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	5.3	0.4	1.7	2.3	0.4	2.0
Medication: Atenolol	0.8	1.0	2.2	1.5	0.2	1.2	1.1	-0.1
Medication: Levothyroxine sodium	2.4	4.1	7.2	-2.2	-2.7	-1.1	-1.9	-1.8
Sitting height	1.8	12.5	40.6	3.4	0.2	-6.4	-2.0	-2.4
Chronic bronchitis/emphysema (father)	0.9	1.0	3.7	-0.1	0.4	-1.9	0.3	1.1
High blood pressure (mother)	0.1	0.1	0.3	0.3	0.0	-0.3	-0.3	0.5
Body mass index (BMI)	0.5	2.3	5.9	0.7	2.4	-0.6	-0.5	2.2
Impedance of leg (left)	0.5	2.5	5.2	1.5	-0.8	0.6	2.3	-2.0
Leg predicted mass (left)	1.0	5.4	17.5	1.8	1.4	-4.2	-2.1	0.2
Trunk fat mass	0.9	4.1	8.0	2.8	2.4	-2.4	-0.4	0.9
Waist circumference	0.8	2.9	7.2	0.5	2.5	-0.9	-0.0	2.7
Number of incorrect matches in round	1.1	1.8	7.0	-0.3	0.0	2.6	-1.3	0.2
Past tobacco smoking	0.3	0.5	1.0	-1.0	0.4	-0.2	1.0	0.8
Alcohol usually taken with meals	1.1	1.8	8.6	-0.5	-0.1	-2.9	-0.0	-0.5
Nervous feelings	0.4	0.7	2.0	-0.2	0.7	0.2	1.0	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.5	-1.9	-1.4	-0.7	-0.7	-0.2
Hearing difficulty/problems with background noise	1.2	1.9	5.9	0.5	1.5	2.4	-1.0	0.6
Hair/balding pattern: Pattern 2	0.6	0.8	3.1	0.7	-0.1	-1.8	0.5	0.4
Had menopause	1.2	1.5	3.2	-0.4	-1.4	-0.7	-1.8	-1.3
Had other major operations	0.2	0.2	0.6	-0.8	-0.1	0.6	-0.2	0.3
Forced vital capacity (FVC)	0.5	2.0	9.1	0.0	-0.2	-3.0	0.4	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.0	0.4	1.7	0.5	1.2	1.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.2	-0.8	0.1	0.1	-1.1	-0.3
Qualifications: None of the above	1.0	2.1	4.5	-0.0	1.5	2.1	1.2	1.5
Financial difficulties in last 2 years	0.9	1.3	2.8	-1.3	1.0	0.2	-0.9	1.7
Mouth/teeth dental problems	0.9	1.3	2.7	-1.5	-0.4	-1.6	-0.3	1.2
Heart attack	0.3	0.4	1.2	-0.3	0.3	1.1	-0.6	0.5
Allergy	0.2	0.5	1.8	0.6	0.4	1.4	0.2	-0.3
Pain all over the body in last month	1.5	1.6	4.0	0.4	0.6	2.0	-1.8	-0.6
Diabetes (self-reported)	0.4	0.6	1.3	1.1	-0.7	-0.4	-0.1	-1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.7	-0.6	0.9	-0.5	0.9	1.6
Medication: Ramipril	0.5	0.6	1.2	-0.8	-0.6	-1.1	-0.5	0.8
Medication: Simvastatin	1.4	2.1	5.4	-0.9	0.3	-2.3	2.0	0.4
Fluid intelligence score	0.9	1.8	3.0	-0.8	-1.7	-0.7	-1.6	-1.5
Illnesses of siblings	0.2	0.2	0.6	0.6	0.8	0.0	0.5	-0.1
Neuroticism score	0.1	0.2	0.4	0.6	0.4	0.2	-0.5	-0.1
Weight	1.2	5.8	14.5	2.6	2.5	-3.8	-0.9	0.9
Impedance of arm (right)	0.6	2.9	6.2	1.5	-1.4	-1.7	1.1	-2.5
Arm fat percentage (right)	0.6	2.4	5.5	1.8	2.3	-1.0	0.0	1.4
Trunk fat-free mass	1.0	5.7	19.2	2.0	1.0	-4.4	-2.0	-0.4
Hip circumference	1.3	5.5	10.9	1.8	3.1	-3.3	0.3	1.9
Time employed in main current job	0.8	1.0	3.3	1.8	0.9	0.2	0.1	-0.8
Alcohol intake versus 10 years previously	0.2	0.3	1.1	-0.3	-0.2	1.1	0.6	0.1
Father’s age at death	1.6	2.1	5.9	1.1	-1.8	0.1	0.6	-2.4
Worrier / anxious feelings	0.2	0.5	1.2	-1.1	-0.1	-0.9	-0.5	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	4.0	-2.0	-0.5	-0.7	-1.2	1.0
Falls in the last year	0.1	0.1	0.3	0.5	-0.2	-0.4	0.1	-0.0
Hair/balding pattern: Pattern 3	2.0	2.9	9.9	-3.1	0.5	0.9	0.5	1.9
Number of live births	0.8	1.2	3.9	-0.2	-0.5	2.0	-1.3	-0.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	9.5	0.1	-0.3	-3.1	1.1	-0.8
Pulse rate	0.5	0.8	1.5	0.3	0.7	-1.2	1.2	0.7
Happiness	0.7	0.8	1.4	-1.1	-1.2	-1.2	0.3	0.3
Noisy workplace	0.6	0.7	1.5	1.1	1.2	0.8	0.0	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.8	0.9	0.1	-0.9	-0.5	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.5	-1.0	1.1	1.2	1.1	1.6
Mouth/teeth dental problems: Dentures	0.4	0.6	1.9	0.9	-0.5	-0.3	-0.4	-1.4
Asthma	0.6	1.1	1.8	1.3	0.8	1.3	-1.2	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	0.9	0.5	0.9	0.4	0.6
Medication: Cholesterol lowering	2.4	3.7	8.1	-1.6	0.2	-2.3	2.8	1.7
Depression (self-reported)	0.5	0.5	1.5	-1.2	0.3	-0.5	-0.7	0.6
Medication: Lansoprazole	1.1	1.2	2.6	1.0	1.1	1.6	-0.3	1.1
Prospective memory result	0.2	0.2	0.6	0.7	-0.1	0.4	0.8	0.0
Lung cancer (father)	2.3	2.7	6.5	-0.3	-1.7	0.1	-2.5	-2.0
Illnesses of mother	0.3	0.4	0.9	0.1	0.1	0.9	-0.9	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	5.1	0.4	0.2	-2.2	1.1	-0.7
Pulse wave Arterial Stiffness index	3.6	4.3	9.5	-2.4	1.0	-2.1	0.6	3.1
Impedance of arm (left)	0.3	1.5	3.0	1.7	-0.2	-0.9	1.3	-1.4
Arm fat mass (right)	0.8	3.1	5.0	2.0	2.2	-2.1	-0.7	1.2
Trunk predicted mass	1.0	5.9	20.0	2.1	1.0	-4.5	-2.0	-0.5
Standing height	1.6	15.7	47.2	4.2	0.1	-6.9	-1.6	-3.3
Length of working week for main job	1.8	2.0	4.2	1.5	1.8	2.1	-0.4	0.6
Exposure to tobacco smoke at home	0.6	0.7	2.3	1.5	1.0	-0.2	0.1	0.3
Breastfed as a baby	0.5	0.7	1.3	-0.1	1.0	1.1	-0.7	0.8
Tense / ‘highly strung’	0.3	0.6	2.2	-0.0	0.2	1.5	0.6	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	4.5	-0.5	0.1	-2.1	0.3	0.2
Hair/balding pattern: Pattern 4	1.6	3.8	10.3	-0.7	1.5	1.5	3.2	2.0
Birth weight of first child	0.2	0.4	1.6	0.1	0.1	-1.3	-0.5	0.5
Peak expiratory flow (PEF)	0.4	0.9	2.7	-0.1	0.4	-1.6	1.3	-0.1
Pulse wave reflection index	1.9	2.3	5.1	-2.2	-1.8	-0.2	-1.9	0.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.0	1.0	-0.3	1.0	-0.7	-1.0
Loud music exposure frequency	1.4	1.5	3.2	-0.9	-1.8	-0.4	-1.0	-1.5
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.5	1.0	-1.4	-1.7	-1.0	-1.9
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	0.5	0.6	-0.2	1.0	0.5
Blood clot in the leg (DVT)	1.8	2.4	6.5	-0.4	0.5	-1.0	2.0	2.5
Medication: Paracetamol	0.1	0.2	0.5	-0.4	0.2	-0.7	-0.3	0.4
Headache pain in last month	0.1	0.2	0.7	0.4	0.3	0.8	0.2	-0.4
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	7.6	1.8	-0.2	2.8	-1.5	-2.0
Glaucoma (self-reported)	3.2	3.8	11.1	-0.5	-2.0	1.1	-3.3	-1.4
Gout (self-reported)	0.4	0.5	1.4	-0.1	-0.7	1.2	-0.6	0.2
Hypothyroidism/myxoedema (self-reported)	2.4	4.6	7.6	-1.8	-2.8	-1.5	-1.8	-2.6
Medication: Amlodipine	1.5	2.0	4.2	-1.9	0.6	-0.7	-1.2	2.0
Medication: Ventolin 100micrograms inhaler	1.1	1.5	4.2	-1.0	1.4	-0.2	-0.3	2.0
Birth weight	0.4	0.9	3.6	-0.9	0.3	-1.9	-0.5	0.0
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.9	-1.4	0.1	1.3	-0.9	0.7
High blood pressure (siblings)	0.9	1.3	2.6	-0.5	-1.6	-1.2	-1.0	-1.0
Forced vital capacity (FVC), Best measure	0.3	1.0	3.9	0.4	0.0	-2.0	0.4	-1.0
Body fat percentage	0.8	3.0	6.6	2.2	2.6	-0.9	0.5	1.6
Leg fat percentage (right)	0.5	1.7	4.1	1.1	2.0	-0.1	0.5	1.7
Arm fat-free mass (right)	0.8	3.9	8.7	2.1	1.6	-3.0	-2.0	0.2
Exposure to tobacco smoke outside home	1.3	1.7	5.2	1.4	2.3	0.8	-0.1	0.9
Comparative body size at age 10	0.5	1.3	3.1	1.1	-0.4	-1.8	-0.7	-1.2
Number of full brothers	1.6	2.1	6.7	0.2	0.1	2.6	-1.8	0.3
Worry too long after embarrassment	0.2	0.3	0.5	0.7	0.5	-0.5	-0.7	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.3	1.1	1.2	-0.0	-0.1	0.0
Wheeze or whistling in the chest in last year	1.5	2.7	6.7	-0.9	1.1	2.6	-0.4	2.2
Number of children fathered	0.2	0.3	0.5	-0.4	0.3	0.7	-0.5	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	1.2	-1.1	-0.7	-0.5	-0.8	0.8
Age at first live birth	0.8	1.4	3.1	1.3	0.6	-1.4	1.8	0.1
Pulse wave peak to peak time	3.7	4.3	10.4	2.5	-1.1	1.8	-0.8	-3.2
Health satisfaction	0.4	0.5	1.8	0.6	1.3	-0.2	0.3	0.4
Shortness of breath walking on level ground	0.7	0.9	1.7	0.2	1.3	0.2	-1.2	1.1
Qualifications: College or University degree	0.4	1.4	4.8	-0.9	-0.8	-2.2	-0.1	-0.8
Eye problems/disorders: None of the above	1.8	2.1	4.3	-2.1	0.3	-1.7	1.0	1.4
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.8	0.6	-0.3	1.7	-1.3	-0.4
Emphysema/chronic bronchitis	0.9	1.1	3.4	-0.0	1.1	1.8	-0.5	0.7
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	-0.4	0.4	-0.2	-0.0	0.5
Neck or shoulder pain in last month	0.6	0.9	3.0	-0.7	1.0	0.3	0.1	1.7
Medication: Blood pressure	0.8	1.5	3.5	-1.5	-0.4	-1.9	-0.7	1.0
Angina (self-reported)	1.0	1.3	2.7	1.0	1.3	1.6	-1.0	0.2
Migraine (self-reported)	0.1	0.1	0.2	-0.2	-0.1	0.4	-0.2	-0.4
Medication: Ibuprofen	0.5	0.7	0.9	1.0	0.6	0.8	0.9	0.7
Medication: Allopurinol	0.4	0.6	0.9	-0.8	-0.6	0.9	-0.9	0.5
Medication: Omeprazole	0.7	0.9	3.6	0.7	0.3	1.9	0.3	-0.4
Medication: Seretide 50 evohaler	1.4	1.6	4.3	-2.1	0.4	-0.1	-1.7	0.9
Mean time to correctly identify matches	0.6	1.2	3.8	-0.3	1.0	2.0	0.1	1.1
Heart disease (mother)	0.7	0.8	2.0	-1.4	0.1	-0.2	0.9	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.1	5.1	1.7	0.8	2.3	-1.0	-0.8
Whole body fat mass	0.9	3.6	6.2	2.4	2.5	-2.2	-0.3	1.1
Leg fat mass (right)	0.6	2.5	4.2	1.8	2.0	-2.0	-0.4	1.1
Arm predicted mass (right)	0.8	4.2	10.0	2.0	1.6	-3.2	-2.0	0.2
Pulse rate, automated reading	1.6	5.2	15.1	0.4	0.8	-3.9	2.8	1.5
Alcohol intake frequency.	1.3	3.0	7.4	1.8	1.6	-0.4	2.7	1.2
Comparative height size at age 10	1.7	9.1	38.2	2.3	0.7	-6.2	-0.7	-0.9
Number of full sisters	1.7	2.0	5.3	-0.7	-1.7	0.3	-2.3	-1.1
Suffer from ‘nerves’	0.5	0.7	2.8	-0.7	-0.5	0.1	-1.7	-0.2
Overall health rating	1.0	2.2	5.6	0.1	2.4	0.6	-0.5	2.1
Chest pain or discomfort	0.7	1.0	3.2	-1.2	-0.0	1.8	-0.8	0.1
Had major operations	0.3	0.4	1.3	-0.1	0.3	-1.1	0.5	0.4
Age at last live birth	0.2	0.4	0.9	0.6	-0.2	1.0	0.3	-0.6
Family relationship satisfaction	1.2	1.5	2.7	-1.1	-1.7	0.7	-1.6	-0.8
Leg pain on walking	2.8	3.5	6.7	1.4	2.2	2.6	0.1	1.9
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	0.3	0.4	0.4	-0.5	0.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.0	0.4	1.4	-0.7	-0.1	1.4
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.1	1.3	-0.5	-1.8	-0.2	-1.4
Medication: Aspirin	1.1	1.4	3.3	-1.3	-1.2	-1.8	-0.3	-0.8
Supplements: Vitamin C	0.3	0.3	1.1	-1.1	-0.5	-0.4	0.2	0.2
Knee pain experienced in last month	1.2	1.8	3.5	0.9	1.9	-0.2	1.2	1.8
Hypertension (Self-reported)	0.3	0.7	1.9	-0.0	1.4	0.3	0.5	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.0	0.5	-0.6	0.9	0.6	-1.0
Illnesses of father: Heart disease	0.6	0.9	2.5	-0.9	0.9	0.3	0.6	1.6
Illnesses of siblings: Diabetes	1.2	1.5	3.2	0.3	-1.8	-1.2	-1.0	-1.4
Smoking status: Previous	0.2	0.4	0.6	0.8	-0.5	-0.6	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	8.2	0.7	0.1	-2.9	-1.5	-1.2
Whole body fat-free mass	1.0	5.5	17.8	2.0	1.3	-4.2	-2.0	-0.0
Leg fat-free mass (right)	1.0	5.2	16.8	1.7	1.4	-4.1	-2.1	0.2
Arm fat percentage (left)	0.8	3.3	8.4	2.0	2.9	-0.9	0.3	1.9
Average weekly red wine intake	1.2	1.8	5.0	-1.4	0.7	-2.2	-1.0	0.7
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	-0.8	0.0	0.3	-0.8	0.2
Mood swings	0.1	0.3	0.5	-0.0	-0.5	-0.5	-0.4	-0.7
Loneliness, isolation	0.1	0.1	0.4	-0.1	0.6	-0.4	0.3	0.1
Long-standing illness, disability or infirmity	1.8	2.7	7.9	-0.2	2.0	-0.9	0.9	2.8
Ever had bowel cancer screening	0.3	0.4	1.2	-0.1	0.3	-0.6	0.4	1.1
Diabetes diagnosed by doctor	0.9	1.5	2.3	1.2	-1.1	-1.5	-0.4	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.2	-1.5	-0.5	-0.9	1.0	0.5
Friendships satisfaction	0.4	0.5	1.3	0.1	-0.4	0.2	-1.1	-1.1
Qualifications: nursing, teaching	0.4	0.6	2.9	0.4	-0.3	-1.7	0.2	0.2
Commuting to job workplace: Walk	1.0	1.0	4.1	2.0	0.1	0.5	0.4	-0.8
Eye problems/disorders: Cataract	2.0	2.4	6.0	2.5	-0.8	0.3	-0.8	-2.1
Mouth/teeth dental problems: Mouth ulcers	3.3	5.3	18.1	1.3	2.5	4.2	0.2	0.6
Medication for cholesterol	0.5	0.7	1.3	-1.0	-0.2	1.0	-1.1	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.6	-0.8	0.4	-0.1	0.0	0.2
Back pain experienced in last month	1.3	1.9	3.5	0.0	1.8	-1.1	1.9	1.3
Mineral and other dietary supplements	0.9	1.2	4.5	2.1	1.2	-0.4	-0.1	0.2
Breast cancer (self-reported)	1.2	1.4	3.9	-0.4	-2.0	-0.0	-1.3	-1.2
Asthma (self-reported)	0.9	1.7	2.6	1.6	1.2	1.5	-1.5	0.2
Osteoporosis (self-reported)	0.6	0.7	1.1	0.8	0.7	1.0	1.1	0.7
Osteoarthritis (self-reported)	0.3	0.3	1.0	-0.3	0.4	-0.4	0.4	1.0
Medication: Aspirin	0.9	1.1	3.1	-0.9	-1.0	-1.8	-0.0	-0.8
Medication: Gliclazide	1.1	1.3	2.2	1.1	1.5	0.6	1.1	1.2
Illnesses of father: None of the above (group 1)	1.0	1.2	4.7	0.9	0.5	2.2	-0.4	-0.3
Smoking status: Current	0.9	1.5	3.3	-0.4	-1.8	1.3	-1.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.0	-1.4	-0.2	-0.2	0.9	0.4
Whole body water mass	1.0	5.7	18.6	2.0	1.4	-4.3	-2.1	0.0
Leg predicted mass (right)	1.0	5.4	17.1	1.8	1.4	-4.1	-2.1	0.3
Arm fat mass (left)	0.9	3.8	8.1	2.2	2.8	-1.9	-0.4	1.6
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.2	0.6	0.3	-0.6	0.3
Average weekly champagne plus white wine intake	1.5	2.0	5.3	-1.6	-1.3	-2.3	0.3	-0.7
Miserableness	0.2	0.3	0.9	0.3	-0.6	0.6	-0.1	-0.9
Guilty feelings	0.2	0.3	0.6	0.8	0.5	-0.4	0.5	0.2
Wears glasses or contact lenses	1.7	1.9	4.2	0.4	1.8	-0.9	2.1	1.1
Ever taken oral contraceptive pill	0.8	0.9	1.9	-0.3	1.4	-0.9	-0.3	1.2
Hearing aid user	0.4	0.5	1.3	0.9	0.5	-1.1	-0.5	-0.2
Mother’s age at death	0.5	0.6	1.5	-0.2	0.1	-0.6	1.2	1.1
Financial situation satisfaction	0.1	0.2	0.3	-0.6	-0.5	0.2	-0.6	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.7	0.1	0.2	1.3	-0.1	-0.3
Commuting to job workplace: Public transport	0.4	0.5	1.1	-0.0	-0.5	-1.0	1.0	0.2
Eye problems/disorders: Glaucoma	2.7	3.2	7.9	-0.4	-1.4	2.3	-2.8	-0.9
Medication: Blood pressure	0.3	0.5	1.1	0.4	1.0	-0.0	1.1	0.6
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	0.3	-0.8	-0.9	0.4	-0.4
Supplements: Fish oil (including cod liver oil)	1.4	1.8	5.8	-2.4	-1.7	-0.4	-0.3	-0.3
High cholesterol (Self-reported)	1.0	1.7	4.8	-0.9	-0.1	-1.7	2.2	0.2
Medication: Bendroflumethiazide	0.3	0.4	1.1	-1.1	0.4	-0.7	-0.5	0.5
Medication: Paracetamol	0.5	0.8	2.8	-1.0	-0.0	-1.7	0.7	0.1
Medication: Lisinopril	0.7	1.0	1.6	1.2	0.8	-1.1	1.3	0.1
Medication: Atorvastatin	1.2	1.5	4.0	-1.7	-2.0	-0.1	-0.3	-0.5
Illnesses of father: High blood pressure	1.8	2.3	6.5	-1.9	-0.1	-2.5	0.6	1.1
Alcohol drinker status: Never	2.9	3.4	6.4	1.9	2.1	2.5	1.2	1.0
Ever smoked	0.1	0.2	0.3	0.4	-0.5	0.3	-0.5	-0.4
Basal metabolic rate	1.0	5.6	17.0	2.2	1.7	-4.1	-1.8	0.2
Leg fat percentage (left)	0.6	2.1	4.7	1.1	2.2	-0.3	0.8	1.9
Arm fat-free mass (left)	0.9	4.6	13.2	2.0	1.4	-3.6	-2.0	0.1
Number of operations (self-reported)	0.2	0.2	0.7	0.1	0.5	-0.9	-0.1	0.4
Average weekly beer plus cider intake	0.9	1.2	6.0	0.3	-0.1	2.4	0.0	0.3
Irritability	0.5	0.8	1.2	1.0	-0.8	-0.7	-1.1	-0.9
Risk taking	0.1	0.2	0.5	0.7	-0.2	0.5	0.2	0.1
Ever had prostate specific antigen (PSA) test	1.5	1.7	6.2	-0.9	-0.7	-2.5	1.0	-0.0
Fractured/broken bones in last 5 years	1.2	1.5	3.3	1.4	-1.3	0.8	0.3	-1.8
Age started oral contraceptive pill	1.0	1.3	2.7	0.6	1.2	1.3	-1.6	0.3
Diastolic blood pressure, automated reading	1.0	3.1	8.4	0.3	-1.9	-2.9	0.3	-1.8
Ever depressed for a whole week	0.8	0.9	1.7	-1.2	1.3	-0.1	-0.1	1.2
Unable to work because of sickness or disability	0.7	0.9	1.9	0.0	1.4	-0.1	0.7	1.3
Commuting to job workplace: Cycle	2.8	3.4	5.8	-0.8	-2.3	0.9	-2.1	-2.4
Myopia	0.2	0.3	0.7	-0.3	-0.8	-0.0	-0.9	-0.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.4	0.0	-1.8	-0.9	-0.3	-1.5
Cholesterol lowering medication	0.1	0.1	0.2	0.5	-0.0	-0.4	-0.0	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.6	1.2	0.3	1.9	0.4	-0.5
Pain experienced in last month	0.3	0.5	1.2	-1.1	-1.1	-0.5	-0.3	-0.0
Supplements: Calcium	0.4	0.4	1.0	-0.2	0.6	-1.0	0.6	0.5
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	1.0	0.3	0.3	-0.3	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.1	0.0	0.2	1.0	-0.6	0.3
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	6.0	-0.4	0.5	-1.1	2.0	2.4
Heart disease (siblings)	0.2	0.3	0.5	-0.7	-0.1	0.4	-0.6	0.5
Alcohol drinker status: Previous	1.4	1.6	3.5	0.7	0.8	-1.9	1.5	1.2
Pack years of smoking	0.3	0.5	1.8	-0.2	-0.3	0.6	-1.4	-0.4
Impedance of whole body	0.4	2.3	4.0	1.9	-0.7	0.2	1.8	-2.0
Leg fat mass (left)	0.7	2.9	5.0	1.9	2.2	-2.0	-0.3	1.3
Arm predicted mass (left)	0.8	4.2	10.4	2.1	1.6	-3.2	-1.9	0.2