Best TWAS P=7.3e-15 · Best GWAS P=1.13e-07 conditioned to 0.464
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | MADD | 0.44 | 0.14 | lasso | 7 | 0.21 | 4.0e-06 | -3.6 | 5.6 | 1.8e-08 | -0.71 | 0.04 | 0.88 | FALSE |
| 2 | GTEx | Brain Cerebellum | MADD | 0.21 | 0.00 | enet | 13 | 0.11 | 3.3e-04 | -4.6 | 5.8 | 6.0e-09 | -0.75 | 0.02 | 0.90 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | MADD | 0.19 | 0.00 | enet | 17 | 0.09 | 3.3e-07 | -4.7 | 7.8 | 7.3e-15 | -0.61 | 0.01 | 0.98 | TRUE |
| 4 | GTEx | Heart Left Ventricle | MADD | 0.14 | 0.01 | enet | 17 | 0.05 | 7.0e-04 | -4.3 | 6.3 | 2.4e-10 | -0.67 | 0.05 | 0.86 | FALSE |
| 5 | YFS | Blood | NR1H3 | 0.34 | 0.15 | enet | 66 | 0.24 | 3.1e-76 | -2.8 | 5.4 | 5.4e-08 | -0.51 | 0.74 | 0.04 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ACP2 | 0.02 | 0.01 | blup | 44 | 0.02 | 2.7e-04 | -4.6 | 5.2 | 1.5e-07 | -0.83 | 0.01 | 0.75 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MADD | 0.08 | 0.01 | lasso | 5 | 0.05 | 3.1e-06 | 2.0 | 5.5 | 4.2e-08 | -0.44 | 0.07 | 0.18 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MADD | 0.15 | 0.04 | enet | 10 | 0.06 | 4.5e-07 | -3.5 | 5.9 | 3.3e-09 | -0.38 | 0.11 | 0.22 | FALSE |
| 9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | MADD | 0.21 | 0.04 | blup | 64 | 0.07 | 1.3e-03 | -4.2 | 5.3 | 8.7e-08 | -0.74 | 0.03 | 0.43 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | C1QTNF4 | 0.04 | 0.01 | blup | 15 | 0.03 | 7.9e-04 | 5.1 | -5.7 | 1.5e-08 | 0.45 | 0.00 | 0.85 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | MADD | 0.07 | 0.00 | enet | 11 | 0.03 | 6.7e-04 | -5.3 | 6.8 | 9.8e-12 | -0.74 | 0.01 | 0.79 | FALSE |