Best TWAS P=5.37e-24 · Best GWAS P=4.39e-26 conditioned to 0.0469
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CPNE8 | 0.08 | 0.04 | blup | 392 | 0.06 | 3.2e-08 | 6.8 | 6.7 | 1.5e-11 | -0.53 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Colon Transverse | CPNE8 | 0.15 | 0.04 | lasso | 6 | 0.06 | 6.9e-04 | 7.9 | 8.1 | 7.1e-16 | -0.55 | 0.46 | 0.15 | FALSE |
| 3 | GTEx | Colon Transverse | RP11-396F22.1 | 0.23 | 0.10 | enet | 21 | 0.10 | 1.9e-05 | -10.0 | 9.6 | 1.3e-21 | -0.79 | 0.02 | 0.98 | TRUE |
| 4 | GTEx | Nerve Tibial | RP11-396F22.1 | 0.11 | 0.05 | lasso | 3 | 0.06 | 4.8e-05 | 9.2 | 7.0 | 2.1e-12 | -0.54 | 0.41 | 0.36 | FALSE |
| 5 | GTEx | Stomach | CPNE8 | 0.11 | 0.08 | lasso | 4 | 0.01 | 1.0e-01 | 9.6 | -9.7 | 3.9e-22 | 0.76 | 0.08 | 0.19 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ALG10B | 0.01 | 0.01 | blup | 30 | 0.00 | 3.9e-02 | 9.3 | 9.4 | 5.0e-21 | -0.80 | 0.03 | 0.53 | FALSE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ALG10B | 0.05 | 0.03 | lasso | 3 | 0.02 | 1.3e-02 | -10.2 | 10.1 | 5.4e-24 | -0.89 | 0.02 | 0.67 | TRUE |