TWAS hub - ALG10B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue (Male)	0.00986	0.0301	0.3900	-0.013	NA	-0.009	NA	-0.012	1.0e+00	NA	0.57000	NA	0.75000
2	GTEx	Breast Mammary Tissue (Female)	0.00055	0.0282	0.4900	-0.008	NA	0.006	NA	0.024	7.0e-01	NA	0.21000	NA	0.06300
3	GTEx	Skin Sun Exposed Lower leg	0.04500	0.0250	0.0015	0.023	NA	0.028	NA	0.024	4.4e-03	NA	0.00220	NA	0.00410
4	ROSMAP	Brain Pre-frontal Cortex	0.02540	0.0175	0.0063	0.001	0.015	0.003	0.014	0.004	2.6e-01	0.004	0.12000	0.0052	0.08200
5	TCGA	Breast Invasive Carcinoma	0.01500	0.0099	0.0029	0.011	0.004	0.001	NA	0.003	2.2e-03	0.039	0.18000	NA	0.06300
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.08890	0.0473	0.0036	0.037	0.008	0.027	NA	0.030	5.1e-05	0.034	0.00046	NA	0.00024
7	TCGA	Soft Tissue Sarcoma	0.04800	0.0340	0.0041	0.031	0.011	0.011	NA	0.024	5.6e-03	0.068	0.07100	NA	0.01300
8	TCGA	Stomach Adenocarcinoma	0.12800	0.0780	0.0022	-0.002	0.015	0.000	NA	0.007	4.8e-01	0.028	0.34000	NA	0.08700

Trait	Avg chi2 ratio	Avg chi2	Max chi2	3	4	5	6	7	8
Chronotype (morning person)	11.9	27.5	102.1	-1.7	4.9	9.4	-1.6	10.1	-0.3
Pulse rate, automated reading	5.8	18.9	70.5	1.2	5.4	8.4	0.9	6.9	-1.0
Pulse rate	4.0	6.8	24.8	-0.4	2.7	5.0	-0.5	4.7	-0.6
Medication: Omeprazole	3.7	4.5	11.6	-3.4	-3.3	-2.3	-2.2	-0.7	-1.4
Back pain experienced in last month	3.1	4.5	9.5	-2.9	-2.8	-1.4	-2.9	-0.4	-3.1
Major Depression (MDD)	3.0	3.6	10.5	-2.0	-3.2	-2.7	-1.4	-1.8	-1.3
Had other major operations	3.0	3.6	8.5	-2.4	-2.7	-1.7	-1.9	-1.0	-2.9
Mean time to correctly identify matches	2.9	5.5	12.8	-2.5	-3.6	-2.9	-2.5	-1.9	-2.6
Mineral and other dietary supplements	2.9	3.9	12.3	3.5	1.7	-0.2	3.0	-2.2	1.3
Number of operations (self-reported)	2.9	4.3	9.9	-2.1	-2.9	-2.1	-2.3	-1.3	-3.1
Other serious medical condition/disability diagnosed by doctor	2.7	3.5	8.1	-1.7	-2.9	-2.8	-1.5	-2.3	-1.4
Supplements: Fish oil (including cod liver oil)	2.7	3.5	9.4	-3.1	-1.3	0.8	-2.8	2.7	-1.2
Reaction Time	2.6	5.0	10.6	-1.8	-3.3	-2.8	-2.1	-2.4	-2.8
Triglycerides	2.6	4.2	9.9	-3.1	-2.8	-1.0	-2.3	-0.2	-3.1
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	7.8	-2.7	-2.8	-2.4	-1.4	-1.2	-1.1
Diabetes (mother)	2.4	3.0	8.2	-1.6	-2.4	-2.3	-2.9	-1.3	-0.8
Qualifications: nursing, teaching	2.4	3.7	8.7	2.9	0.8	-1.8	2.4	-2.6	2.1
Type 2 Diabetes (T2D) (2012)	2.3	2.6	8.3	-0.3	-2.1	-2.9	0.8	-2.7	0.3
Lupus	2.2	3.4	8.2	-2.1	-2.8	-1.8	-1.5	-0.9	-2.9
Ever had bowel cancer screening	2.2	2.6	8.0	-2.8	-2.7	-1.5	-1.3	0.1	-1.4
Health satisfaction	2.1	2.8	7.6	-1.0	-1.9	-1.7	-1.8	-1.9	-2.7
Wears glasses or contact lenses	2.1	2.4	5.2	-2.3	-2.2	-1.8	-2.1	-0.4	-1.2
Eye problems/disorders: Glaucoma	2.1	2.5	6.9	1.8	2.6	2.4	-0.4	1.8	0.6
LDL Cholesterol	1.9	3.0	9.2	-2.5	-1.1	0.7	-3.0	1.2	-2.4
Time employed in main current job	1.9	2.2	7.1	1.4	2.2	2.7	0.4	1.7	-0.7
Exposure to tobacco smoke outside home	1.9	2.6	8.7	2.6	0.6	-1.4	1.5	-3.0	0.5
Commuting to job workplace: Car/motor vehicle	1.9	2.1	6.6	1.1	1.5	1.0	2.2	1.1	2.6
Taking other prescription medications	1.8	2.9	9.9	-3.1	-2.5	-1.6	-1.4	-0.6	-1.4
Medication: Ramipril	1.8	2.3	8.7	-1.0	1.0	2.5	-0.6	3.0	-0.8
Illnesses of siblings	1.8	2.6	8.6	1.1	2.0	2.9	-0.7	2.5	-0.4
Glaucoma (self-reported)	1.8	2.2	6.2	1.8	2.5	2.3	-0.2	1.6	0.4
Overall health rating	1.8	3.8	9.7	-1.0	-2.3	-3.0	-1.1	-3.1	-1.9
Number of incorrect matches in round	1.7	2.8	8.4	0.6	2.2	2.8	-0.4	2.9	0.2
High blood pressure (siblings)	1.7	2.4	8.1	-0.7	-1.9	-2.8	0.8	-2.5	-0.1
Alcohol intake versus 10 years previously	1.6	2.4	7.0	-0.7	-2.0	-2.5	-1.3	-2.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.7	8.9	-0.1	-2.2	-3.0	-1.2	-2.4	-0.6
Hair/balding pattern: Pattern 3	1.6	2.5	8.6	-0.1	1.3	2.6	-1.6	2.9	-0.5
Knee pain experienced in last month	1.6	2.5	8.3	0.0	-1.7	-2.8	-0.2	-2.9	-1.0
Respiratory disease	1.5	3.4	10.2	-2.8	-3.2	-2.2	-1.1	-1.2	-1.3
Illnesses of mother	1.5	1.9	6.6	-0.1	1.5	2.6	-0.4	2.4	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.4	8.1	-0.7	-1.9	-2.8	-0.5	-2.5	-0.5
Medication: Seretide 50 evohaler	1.5	1.8	8.3	-2.9	-1.6	-0.0	-1.5	0.8	-0.5
Osteoarthritis (self-reported)	1.5	1.9	5.4	-1.8	-2.3	-1.9	-1.2	-1.2	-0.8
Miserableness	1.5	2.5	10.8	3.3	1.4	-0.7	1.5	-2.0	0.9
Waist Hip Ratio (WHR)	1.4	6.1	17.6	-0.7	-3.1	-4.2	-0.6	-4.1	-1.8
Eye problems/disorders: None of the above	1.4	1.6	5.1	-1.8	-2.3	-1.7	-0.2	-0.8	-0.8
Handedness (chirality/laterality): Left-handed	1.4	1.6	5.0	-2.2	-2.0	-0.9	-1.5	0.3	-1.0
Serious illness, injury or assault to yourself	1.3	1.5	4.0	-1.4	-2.0	-1.8	-0.6	-1.2	-1.1
Supplements: Glucosamine	1.3	1.7	6.4	-2.5	-1.5	-0.2	-1.1	1.2	-1.6
Medication: Simvastatin	1.3	1.9	4.8	-2.2	-1.5	0.3	-1.6	1.4	-2.0
Medication: Ventolin 100micrograms inhaler	1.3	1.7	7.1	-2.7	-1.3	0.1	-1.4	0.6	-1.5
Alcohol intake frequency.	1.3	3.0	13.9	1.1	-0.8	-2.8	0.6	-3.7	-0.1
Asthma (self-reported)	1.3	2.6	6.5	-2.5	-2.5	-1.2	-1.7	-0.4	-1.8
Medication: Aspirin	1.3	1.7	6.8	-2.6	-2.2	-1.3	-0.3	0.2	-0.3
Commuting to job workplace: Public transport	1.3	1.6	4.0	0.5	-1.1	-1.5	-1.4	-2.0	-1.7
High cholesterol (Self-reported)	1.3	2.3	6.7	-2.6	-1.5	0.6	-1.3	1.8	-2.1
Pain experienced in last month	1.3	2.2	5.5	1.8	2.4	1.6	1.9	0.7	1.5
Smoking Status	1.2	3.0	10.2	-3.2	-1.9	0.4	-1.2	1.6	-2.4
Qualifications: CSEs or equivalent	1.2	1.6	3.8	2.0	1.9	1.1	1.3	-0.0	1.5
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.2	-0.8	-1.7	-1.8	-1.2	-1.6	-1.3
Asthma	1.2	2.4	6.1	-2.5	-2.5	-1.2	-1.6	-0.5	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	4.9	-0.6	-1.5	-1.9	-0.6	-2.2	-1.2
Wheeze or whistling in the chest in last year	1.2	2.2	5.3	-2.3	-2.2	-0.9	-1.9	-0.2	-1.8
Medication: Aspirin	1.2	1.6	7.6	-2.8	-2.0	-0.8	-0.6	0.6	-0.5
Supplements: Vitamin C	1.2	1.4	3.5	-1.7	-1.9	-1.6	-1.2	-0.8	-0.5
Illnesses of father: None of the above (group 1)	1.2	1.4	3.6	1.6	1.6	1.9	-0.9	1.1	-0.9
Medication: Atorvastatin	1.2	1.4	5.6	-2.4	-1.3	0.3	-0.6	1.3	-1.4
Heart disease (siblings)	1.2	1.5	4.8	-1.3	-1.7	-2.2	-0.6	-1.3	0.5
Heel T-Score	1.1	9.1	22.5	-4.5	-4.7	-2.2	-3.7	-0.5	-3.4
Relative age of first facial hair	1.1	2.3	10.3	1.4	-0.6	-2.4	-0.6	-3.2	0.1
Severe depression (siblings)	1.1	1.2	3.4	-1.0	-1.8	-1.8	0.1	-1.4	-0.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.3	0.8	0.6	1.4	-1.8	0.6	-1.8
High blood pressure (mother)	1.1	1.5	4.5	1.0	-0.5	-2.1	1.5	-1.9	0.8
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.6	1.9	0.4	-0.9	1.7	-1.4	1.0
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	8.2	2.0	-0.1	-1.6	0.1	-2.9	0.1
Worry too long after embarrassment	1.1	1.8	4.2	1.9	2.0	1.6	0.7	1.2	1.4
Number of children fathered	1.1	1.2	3.0	-1.3	-1.7	-1.5	-1.1	-1.1	-0.6
Migraine (self-reported)	1.1	1.4	5.7	2.4	1.5	-0.1	0.8	-1.2	1.0
Family relationship satisfaction	1.1	1.4	3.7	1.8	1.9	1.4	0.9	0.4	1.0
Long-standing illness, disability or infirmity	1.1	1.7	4.2	-1.6	-2.1	-1.8	-1.2	-1.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.2	6.1	2.3	1.6	-0.5	1.6	-1.1	2.5
Mother’s age at death	1.1	1.4	3.0	-0.8	-1.6	-1.7	-1.1	-1.6	-1.1
Commuting to job workplace: Cycle	1.1	1.3	3.5	-1.1	-1.5	-0.8	-1.9	-0.3	-1.6
Type 2 Diabetes (T2D) (2018)	1.0	1.8	4.1	-1.3	-2.0	-1.6	-1.3	-1.2	-1.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.1	-1.6	-1.8	-1.6	-0.4	-0.6	-0.3
Average weekly fortified wine intake	1.0	1.2	2.5	1.0	1.3	1.6	0.5	1.5	1.2
Fluid intelligence score	1.0	2.1	6.8	2.6	0.8	-0.6	2.2	-2.0	0.4
Exposure to tobacco smoke at home	1.0	1.1	4.1	-1.3	-0.6	0.4	-1.5	0.4	-2.0
Birth weight	1.0	2.2	4.8	-0.2	-1.7	-1.9	-1.3	-2.2	-2.1
Comparative body size at age 10	1.0	2.7	9.9	-0.7	1.5	2.9	1.0	3.1	0.3
Medication: Bendroflumethiazide	1.0	1.6	3.5	-1.3	-1.9	-1.6	1.1	-1.5	-1.2
Myopia	1.0	1.5	5.1	-0.9	-1.9	-2.2	0.8	-1.4	-0.3
Cholesterol lowering medication	1.0	1.5	4.5	-1.8	-1.9	-0.7	-0.7	-0.4	-2.1
Pack years of smoking	1.0	1.4	6.4	-1.4	-0.8	0.4	-1.5	0.5	-2.5
Sensitivity / hurt feelings	0.9	1.5	5.5	-0.7	0.5	2.0	-1.3	2.3	-0.8
Angina	0.9	1.1	2.9	-0.4	1.2	1.3	1.2	1.7	1.2
Multivitamins +/- minerals	0.9	1.2	2.7	-1.6	-1.7	-1.1	-1.4	-0.0	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	1.9	5.9	-0.4	-1.8	-2.4	0.4	-2.4	-0.6
Mouth/teeth dental problems	0.9	1.4	4.5	0.5	1.2	2.1	1.2	1.7	0.1
Medication: Cholesterol lowering	0.9	1.4	5.3	-2.1	-0.6	0.8	-0.4	2.3	-0.3
Medication: Blood pressure	0.9	1.5	6.1	-0.9	0.9	1.9	0.7	2.5	0.3
Number of full sisters	0.9	1.1	3.9	0.8	-0.3	-1.6	1.1	-2.0	0.7
Loneliness, isolation	0.9	1.2	4.3	2.1	0.5	-0.7	1.8	-1.1	0.6
Eye problems/disorders: Cataract	0.9	1.1	3.4	1.4	1.8	1.3	0.4	0.4	1.1
Schizophrenia (2014)	0.8	1.8	4.1	-2.0	-2.0	-0.9	-1.1	-0.7	-2.0
Ever had hysterectomy (womb removed)	0.8	0.9	3.3	-1.0	0.6	1.4	0.1	1.8	0.5
Age when periods started (menarche)	0.8	1.8	5.9	1.2	-0.2	-1.1	-2.4	-2.0	-1.4
Stomach or abdominal pain in last month	0.8	1.0	3.5	0.2	-1.0	-0.7	-1.5	-0.7	-1.9
Qualifications: A levels/AS levels or equivalent	0.8	1.9	6.1	1.3	-0.4	-1.9	1.8	-2.5	0.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	6.0	2.4	1.2	0.4	1.3	-0.7	0.6
Number of full brothers	0.8	1.0	3.7	0.1	-1.3	-1.9	0.2	-1.7	-0.0
Neck or shoulder pain in last month	0.8	1.1	2.5	-1.2	-1.6	-1.4	-0.9	-0.7	-1.2
Illnesses of siblings: Diabetes	0.8	1.0	2.8	-1.7	-1.6	-1.4	-0.6	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.1	1.5	0.8	-0.8	1.9	-1.3	2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	3.4	1.3	-0.2	-1.2	0.2	-1.8	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.9	-1.7	-0.5	0.1	-0.8	1.3	1.4
Average weekly champagne plus white wine intake	0.8	1.1	4.2	0.1	0.8	1.5	0.3	2.1	1.1
Intelligence (Savage-Jansen 2018)	0.7	2.1	8.5	2.9	1.4	0.0	1.9	-1.5	0.8
Verbal and Numeric Reasoning (VNR)	0.7	1.7	5.6	2.4	0.6	-0.8	1.9	-1.9	0.2
Body Mass Index (BMI) (2010)	0.7	1.0	2.4	0.7	1.4	1.5	0.7	1.4	1.0
Neuroticism (2016)	0.7	1.1	2.7	-1.3	-1.1	-0.4	-1.6	0.1	-1.6
Primary Biliary Cirrhosis	0.7	1.0	4.1	-0.9	0.7	1.5	-0.3	2.0	0.1
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.9	-2.0	-1.5	-0.7	0.1	-0.1	-0.5
Systolic blood pressure, automated reading	0.7	2.1	7.8	-1.1	-2.0	-2.8	-0.0	-1.8	0.2
Vitamin and mineral supplements	0.7	1.0	2.8	1.7	1.4	1.0	1.4	0.0	0.6
Supplements: Zinc	0.7	0.8	2.3	-1.5	-1.1	-0.8	-0.6	-0.3	-1.2
Medication: Metformin	0.7	1.0	3.0	-1.7	-1.6	-0.9	-0.4	0.2	-1.3
Trunk fat percentage	0.7	2.9	8.9	-0.7	-2.2	-3.0	1.1	-2.7	0.3
Hand grip strength (right)	0.7	1.9	4.7	1.7	0.4	-1.3	1.9	-2.2	1.4
Hayfever, allergic rhinitis or eczema	0.7	1.4	5.2	1.7	-0.1	-1.2	1.4	-2.3	0.1
Falls in the last year	0.7	0.9	2.9	1.7	1.6	1.0	0.7	-0.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	7.1	2.7	1.9	0.2	1.5	-0.5	2.3
Pulse wave Arterial Stiffness index	0.7	0.8	3.2	-1.8	-0.4	0.6	-0.3	0.7	-1.5
Impedance of arm (left)	0.7	3.3	11.8	0.6	-2.0	-3.4	-0.1	-3.2	0.6
Blood clot in the leg (DVT)	0.7	0.9	3.6	1.1	0.0	-1.2	0.6	-1.9	0.6
Pulse wave peak to peak time	0.7	0.8	3.5	1.9	0.4	-0.6	0.2	-0.9	1.4
Angina (self-reported)	0.7	1.0	2.2	-0.4	1.1	1.2	1.0	1.5	1.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.8	0.8	1.5	1.7	0.2	0.9	-0.3
Arm fat percentage (left)	0.7	2.7	6.8	0.2	-1.2	-2.6	2.2	-2.6	1.4
Average weekly red wine intake	0.7	1.0	2.9	-1.3	-0.1	-0.1	1.3	1.4	1.7
Friendships satisfaction	0.7	0.8	2.0	1.3	1.4	1.4	0.1	0.6	-0.9
Commuting to job workplace: Walk	0.7	0.8	3.9	0.9	-0.1	-1.1	0.5	-2.0	-0.4
Medication for cholesterol	0.7	1.1	2.7	0.5	1.2	1.1	-1.0	1.5	1.6
Number of self-reported non-cancer illnesses	0.7	1.2	3.9	-0.7	-1.2	-1.9	0.4	-2.0	-0.4
Ever taken oral contraceptive pill	0.7	0.8	2.4	1.5	1.0	-0.2	1.5	-0.9	-0.4
Hearing aid user	0.7	0.8	2.5	-1.4	-1.0	-0.5	-1.6	0.3	-0.6
Medication: Blood pressure	0.7	1.4	5.6	1.2	0.1	-1.1	1.6	-2.4	-0.8
Fractured/broken bones in last 5 years	0.7	0.9	3.2	1.2	1.2	0.8	1.8	0.0	-0.1
Age started oral contraceptive pill	0.7	0.9	6.5	-0.5	-0.7	-0.1	-0.5	-0.3	-2.5
Supplements: Calcium	0.7	0.7	1.6	-1.2	-1.3	-0.9	-0.7	-0.4	-1.1
Bipolar Disorder or Schizophrenia	0.6	1.4	4.0	-2.0	-1.5	-0.2	-1.5	0.1	-1.6
Ulcerative Colitis	0.6	0.8	2.5	-1.0	-0.7	-1.6	1.0	-0.9	0.8
Pack years adult smoking proportion	0.6	1.0	4.8	-1.2	-0.7	0.3	-1.0	0.3	-2.2
Fed-up feelings	0.6	1.0	3.1	-0.5	-1.7	-1.8	-0.8	-1.3	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	5.8	-0.0	-1.2	-2.0	0.1	-2.4	-0.5
Qualifications: None of the above	0.6	1.4	3.3	-0.8	0.7	1.8	-1.7	1.8	-0.6
Allergy	0.6	1.3	5.8	-0.7	1.1	1.6	-0.1	2.4	0.7
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.0	1.2	0.2	-1.1	0.4	-1.4	1.3
Impedance of arm (right)	0.6	2.9	10.0	0.6	-1.7	-3.2	-0.3	-3.0	0.7
Arm fat percentage (right)	0.6	2.5	6.7	0.2	-1.2	-2.5	1.9	-2.6	1.4
Medication: Lansoprazole	0.6	0.7	3.9	-0.0	-0.3	-0.8	2.0	-0.3	1.0
Lung cancer (father)	0.6	0.8	2.9	1.0	1.1	0.6	0.7	0.5	1.7
Peak expiratory flow (PEF)	0.6	1.4	4.4	2.1	1.6	0.4	0.6	-0.3	2.0
Pulse wave reflection index	0.6	0.7	2.7	-0.6	-0.4	-0.9	1.2	-0.3	1.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.2	-0.4	-0.8	-1.8	-0.1	-1.2	1.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.7	-1.3	-1.3	-0.7	-1.6	-0.6	-1.3
Had major operations	0.6	0.7	2.0	-0.9	-1.1	-0.7	-1.4	-0.6	-0.9
Diabetes diagnosed by doctor	0.6	0.9	2.2	-0.8	-1.5	-1.5	-0.3	-1.1	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.7	0.3	-0.6	-1.4	-0.9	-1.9	-1.0
Smoking status: Current	0.6	1.0	2.5	-1.6	-0.7	0.8	-0.9	1.4	-1.4
Guilty feelings	0.6	0.9	4.1	-0.6	0.4	1.4	0.2	2.0	0.2
Average weekly beer plus cider intake	0.6	0.8	2.4	1.5	1.2	0.0	0.6	-1.5	-0.1
Ever depressed for a whole week	0.6	0.7	2.4	0.5	-0.7	-1.4	-0.1	-1.5	-0.7
Bipolar Disorder (2018)	0.5	0.7	2.2	-1.1	-0.5	0.8	-0.9	0.7	-1.5
Schizophrenia (2018)	0.5	1.1	2.8	-1.7	-1.5	-0.9	-1.2	-0.5	-1.0
Ovarian Cancer	0.5	0.6	2.5	-0.3	-0.9	-1.3	-0.3	-1.6	-0.2
Allergy or Eczema	0.5	1.4	5.4	1.3	-0.5	-1.6	0.9	-2.3	0.6
Average weekly spirits intake	0.5	0.6	2.3	-0.0	0.9	1.5	0.4	0.9	-0.8
Current tobacco smoking	0.5	0.9	2.2	-1.5	-0.5	0.9	-0.7	1.4	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.2	1.1	-0.3	-1.4	-0.3	-1.5	0.6
Trunk fat mass	0.5	2.2	6.2	-0.4	-1.7	-2.5	1.5	-2.4	0.5
Hair/balding pattern: Pattern 2	0.5	0.6	2.9	0.8	-0.1	-1.1	0.3	-1.7	0.4
Had menopause	0.5	0.6	2.0	-1.4	-1.0	-0.2	-0.3	0.1	-1.4
Prospective memory result	0.5	0.6	1.9	-1.4	-0.2	0.5	0.3	1.4	0.9
Loud music exposure frequency	0.5	0.6	2.9	-1.7	-0.2	0.4	0.4	1.0	-0.3
Body fat percentage	0.5	2.1	5.9	-0.6	-1.8	-2.4	1.2	-2.3	0.6
Shortness of breath walking on level ground	0.5	0.5	2.2	-0.9	-0.7	-0.1	-1.5	0.1	-0.8
Qualifications: College or University degree	0.5	1.6	5.3	-0.5	-1.9	-2.3	0.4	-1.8	-0.3
Suffer from ‘nerves’	0.5	0.8	2.3	1.5	1.1	0.3	1.4	-0.2	0.8
Osteoporosis (self-reported)	0.5	0.7	2.4	0.5	0.5	-0.3	1.4	-0.6	1.5
Medication: Gliclazide	0.5	0.6	1.6	0.0	-0.8	-1.2	0.8	-1.0	1.0
Illnesses of father: High blood pressure	0.5	0.6	2.6	-1.6	-0.5	0.5	-0.2	1.2	-0.3
Unable to work because of sickness or disability	0.5	0.6	2.0	-1.4	-1.1	-1.2	-0.0	-0.6	0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.8	0.8	-0.2	-1.1	0.1	-1.7	0.3
Impedance of whole body	0.5	2.7	8.2	-0.1	-2.1	-2.9	-1.2	-2.7	-0.3
Depressed Affect (Nagel 2018)	0.4	0.8	3.0	0.9	-0.7	-1.4	-0.5	-1.7	0.1
Depression (Nagel 2018)	0.4	0.6	2.1	0.2	-0.9	-1.2	-0.5	-1.4	-0.7
Alzheimer’s Disease (in mother)	0.4	0.4	1.6	-0.6	-0.5	0.6	-0.8	0.5	-1.2
Alzheimer’s Disease (in father)	0.4	0.4	1.8	0.0	-0.4	-0.7	0.9	-0.5	1.3
Bipolar Disorder (2011)	0.4	0.4	1.4	-1.1	-1.2	-0.5	0.0	-0.3	-0.3
Mean Putamen Volume	0.4	0.5	2.9	-0.1	-0.5	-0.3	0.3	0.8	1.7
Fasting Glucose	0.4	0.4	1.1	0.9	0.7	0.2	1.1	-0.2	1.0
Blood Eosinophil Count	0.4	2.8	8.3	-2.2	-2.9	-2.4	-0.8	-1.2	-1.1
Blood White Count	0.4	2.8	8.1	-1.9	-2.9	-2.6	1.3	-1.4	0.3
Hand grip strength (left)	0.4	1.0	3.2	0.5	-0.2	-1.6	0.9	-1.8	1.2
Medication for hormone replacement therapy	0.4	0.4	1.1	-1.1	-0.7	-0.8	0.9	-0.4	-0.0
Relative age voice broke	0.4	0.6	2.4	1.3	0.0	-0.8	-0.2	-1.6	-0.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.6	-1.3	-1.1	-0.4	-0.4	-0.0	-0.9
Waist circumference	0.4	1.5	3.7	-0.8	-1.6	-1.9	1.3	-1.9	-0.2
Financial difficulties in last 2 years	0.4	0.5	1.7	-0.3	-0.6	-1.3	0.4	-1.2	0.7
Pain all over the body in last month	0.4	0.5	1.2	-0.6	-1.0	-0.6	0.6	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	4.9	2.0	1.0	-0.5	1.0	-0.8	2.2
Happiness	0.4	0.5	1.5	0.9	0.1	-0.5	-0.2	-1.2	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.9	1.4	0.6	-0.3	0.8	-0.8	-0.2
Depression (self-reported)	0.4	0.5	2.0	0.6	-0.3	-0.9	0.6	-1.4	-0.5
Length of working week for main job	0.4	0.4	1.9	1.4	1.0	0.6	-0.0	0.3	0.0
Breastfed as a baby	0.4	0.5	1.7	-1.1	-1.3	-0.8	-0.7	-0.0	-0.0
Birth weight of first child	0.4	0.7	1.6	0.2	-0.7	-1.1	-0.8	-1.3	-1.2
Headache pain in last month	0.4	0.7	1.3	-0.2	-1.1	-1.0	-1.0	-1.0	-1.0
Forced vital capacity (FVC), Best measure	0.4	1.5	4.1	2.0	1.6	0.7	1.0	0.2	1.9
Whole body fat mass	0.4	1.5	3.6	-0.2	-1.2	-1.9	1.6	-1.9	0.7
Age at last live birth	0.4	0.6	1.9	0.2	-0.8	-1.3	-0.8	-1.4	-0.6
Leg pain on walking	0.4	0.5	1.8	-0.5	-0.8	-0.6	-1.3	-0.7	-0.7
Breast cancer (self-reported)	0.4	0.5	1.2	-0.1	0.4	1.1	-0.9	0.9	-0.9
Arm fat mass (left)	0.4	1.8	4.7	0.2	-0.8	-1.9	2.2	-2.1	1.1
Financial situation satisfaction	0.4	0.4	1.1	0.3	0.4	1.0	-0.9	0.6	-1.0
Irritability	0.4	0.6	1.7	0.6	-0.5	-1.3	0.7	-1.2	0.8
Ulcerative Colitis (UC)	0.3	0.6	1.6	-1.3	0.2	-0.0	1.1	0.7	1.2
Age at First Birth	0.3	0.5	1.4	0.4	0.2	-0.9	1.2	-1.1	0.5
Crohns Disease (2012)	0.3	0.4	1.2	1.1	0.9	-0.2	0.7	-0.4	0.9
Rheumatoid Arthritis	0.3	0.3	1.0	-1.0	0.4	0.4	-0.5	1.0	0.5
BMI	0.3	1.7	9.1	0.2	0.2	-0.6	3.0	-0.6	2.0
Number of treatments/medications taken	0.3	0.6	1.9	-1.4	-1.0	-0.0	-0.1	0.1	-1.3
Leg fat-free mass (left)	0.3	1.6	8.5	1.2	0.7	-0.3	2.9	-0.8	1.3
Townsend deprivation index at recruitment	0.3	0.5	1.4	-0.6	0.1	1.2	-0.5	1.2	-0.7
Medication: Atenolol	0.3	0.4	1.2	0.6	1.1	0.6	0.7	0.5	0.9
Leg predicted mass (left)	0.3	1.5	7.9	1.2	0.6	-0.4	2.8	-0.8	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.6	0.9	-0.1	-0.9	-0.5	-1.2	-0.2
Diabetes (self-reported)	0.3	0.4	1.2	-0.5	-1.1	-0.9	-0.2	-0.8	-0.8
Trunk fat-free mass	0.3	1.6	5.3	1.6	1.6	0.7	2.3	0.0	1.4
Arm fat mass (right)	0.3	1.4	4.1	0.1	-0.7	-1.6	2.0	-1.7	1.1
Trunk predicted mass	0.3	1.7	5.5	1.6	1.7	0.7	2.4	-0.0	1.4
Hair/balding pattern: Pattern 4	0.3	0.8	1.8	0.6	0.1	-1.3	1.0	-1.2	1.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.9	1.4	1.1	0.8	-0.2	-0.0	-0.6
Medication: Ibuprofen	0.3	0.4	1.3	1.1	0.1	-0.6	0.8	-0.8	0.1
Heart disease (mother)	0.3	0.4	1.0	-0.6	-0.8	-1.0	0.4	-0.7	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.8	-0.6	0.1	0.9	-0.3	1.3	0.4
Comparative height size at age 10	0.3	1.9	5.8	0.4	1.9	2.4	1.1	2.1	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.2	0.7	1.0	0.2	-0.0	-0.4	1.1
Illnesses of father: Heart disease	0.3	0.5	2.7	-0.1	-0.1	-0.7	1.6	-0.7	-0.1
Mood swings	0.3	0.6	2.5	0.1	-0.5	-1.6	0.5	-1.0	0.8
Medication: Paracetamol	0.3	0.4	1.2	-0.6	-0.8	-1.1	0.3	-1.1	0.2
Alcohol drinker status: Never	0.3	0.4	1.1	-0.4	-0.9	-0.5	-0.5	-0.6	-1.0
Alcohol drinker status: Previous	0.3	0.4	1.7	-0.6	-0.3	-0.8	-0.1	-0.3	1.3
Crohns Disease (2017)	0.2	0.4	1.3	-0.8	0.2	0.6	-1.0	1.1	-0.3
Irritable Bowel Disease (IBD)	0.2	0.4	1.0	-1.0	0.5	0.4	0.4	1.0	0.7
Coronary Artery Disease (CAD)	0.2	0.3	0.7	0.7	0.4	0.1	-0.8	-0.7	0.3
Blood Platelet Count	0.2	2.8	7.4	-2.0	-2.7	-2.5	0.7	-1.8	-1.0
Systolic Blood Pressure	0.2	1.0	4.0	-0.3	-1.2	-2.0	0.7	-1.4	-0.2
Hypothyroidism (self reported)	0.2	0.4	1.5	-0.2	-0.6	-0.8	-0.8	-1.2	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.2	1.5	1.2	0.5	0.1	-0.1	-0.2	-0.0
Hearing difficulty/problems: Yes	0.2	0.4	1.1	-1.0	-0.2	0.7	-0.2	1.0	-0.6
Medication: Co-codamol	0.2	0.3	1.1	-0.2	-0.3	-1.0	0.2	-1.1	-0.1
Diabetes (father)	0.2	0.2	0.9	-0.5	0.4	0.7	-0.0	0.9	0.2
Impedance of leg (right)	0.2	0.7	2.8	0.3	-0.8	-1.0	-1.7	-1.2	-0.2
Maternal smoking around birth	0.2	0.3	1.1	-1.0	-0.1	0.3	-0.1	0.6	0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.9	-0.3	-0.7	-0.7	-0.0	-0.9	-0.6
High blood pressure	0.2	0.6	2.3	0.7	1.1	0.8	1.5	0.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.7	0.3	0.3	-0.6	-0.3	-0.6
Medication: Levothyroxine sodium	0.2	0.3	1.4	0.0	-0.6	-0.8	-0.3	-1.2	-0.5
Body mass index (BMI)	0.2	0.7	4.4	-0.2	-0.2	-0.5	2.1	-0.7	0.7
Impedance of leg (left)	0.2	0.9	3.2	-0.5	-1.2	-1.1	-1.8	-0.9	-0.4
Past tobacco smoking	0.2	0.4	1.8	1.3	0.5	-0.3	0.1	-0.8	0.9
Alcohol usually taken with meals	0.2	0.3	0.9	-0.9	-0.8	-0.1	-0.4	0.6	-0.3
Nervous feelings	0.2	0.4	1.1	-0.7	-1.0	-0.9	0.0	-0.6	-0.6
Hearing difficulty/problems with background noise	0.2	0.4	1.3	-0.9	-0.3	0.5	-0.3	0.5	-1.1
Forced vital capacity (FVC)	0.2	0.8	3.3	1.2	0.3	-0.7	0.7	-0.7	1.8
Heart attack	0.2	0.2	1.1	-0.3	0.2	0.3	1.1	0.5	0.2
Weight	0.2	1.1	5.7	0.3	-0.3	-1.0	2.4	-1.3	0.8
Father’s age at death	0.2	0.3	0.9	0.9	0.6	-0.2	-0.9	-0.6	-0.4
Worrier / anxious feelings	0.2	0.3	1.4	-0.0	0.4	0.8	-0.7	1.2	0.1
Noisy workplace	0.2	0.3	1.1	0.1	1.1	0.7	0.1	0.6	0.7
Tense / ‘highly strung’	0.2	0.3	1.4	0.1	-0.6	-1.2	0.0	-1.0	-0.2
Medication: Paracetamol	0.2	0.4	0.8	-0.6	-0.6	-0.9	0.8	-0.8	0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	-0.7	-0.4	-0.4	-0.3	-0.6	-0.5
Leg fat percentage (right)	0.2	0.6	1.3	-0.6	-1.1	-1.1	1.0	-1.2	0.2
Age at first live birth	0.2	0.3	1.1	0.1	-0.8	-1.0	0.1	-0.4	0.6
Emphysema/chronic bronchitis	0.2	0.2	0.7	-0.9	-0.5	0.2	-0.3	0.3	-0.8
Medication: Allopurinol	0.2	0.3	0.9	-0.9	-0.1	0.7	-0.4	0.9	-0.4
Leg fat mass (right)	0.2	0.6	2.2	-0.3	-0.7	-0.9	1.5	-1.0	0.5
Chest pain or discomfort	0.2	0.2	0.8	0.5	0.3	0.5	-0.5	-0.0	-0.9
Hypertension (Self-reported)	0.2	0.7	3.2	0.7	1.1	0.5	1.8	-0.1	0.6
Whole body fat-free mass	0.2	1.3	6.1	1.2	1.1	0.3	2.5	-0.3	1.2
Leg fat-free mass (right)	0.2	1.2	7.0	0.8	0.5	-0.3	2.6	-0.6	1.0
Whole body water mass	0.2	1.2	5.7	1.2	1.1	0.3	2.4	-0.3	1.0
Leg predicted mass (right)	0.2	1.1	6.9	0.7	0.4	-0.3	2.6	-0.5	1.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.7	0.1	0.1	-0.3	-0.8	-0.2	-0.8
Basal metabolic rate	0.2	1.2	6.2	1.1	0.8	-0.1	2.5	-0.6	1.1
Leg fat percentage (left)	0.2	0.8	2.2	-1.2	-1.5	-1.2	0.8	-1.0	0.1
Risk taking	0.2	0.3	1.3	-0.8	0.1	0.2	-1.1	0.2	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.6	-0.0	-0.9	-0.7	-1.3	-0.5	-0.5
Basal cell carcinoma (self-reported)	0.2	0.3	1.2	-0.5	0.1	0.7	0.0	1.1	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.2	1.1	-0.3	0.2	0.4	1.1	0.6	0.1
Leg fat mass (left)	0.2	0.6	2.3	-0.6	-0.8	-0.9	1.5	-0.9	0.5
Arm predicted mass (left)	0.2	0.9	4.4	1.0	1.1	0.4	2.1	-0.4	0.7
Schizophrenia vs Biploar Disorder	0.1	0.2	0.9	0.9	0.2	-0.2	-0.3	-0.3	0.3
Worry (Nagel 2018)	0.1	0.2	0.6	0.1	0.3	0.6	-0.7	0.3	-0.8
Alzheimer’s Disease (including proxy)	0.1	0.1	0.5	0.3	-0.3	-0.3	0.0	-0.7	0.0
HbA1C	0.1	0.1	0.4	-0.3	0.0	-0.1	0.6	0.6	-0.6
HDL Cholesterol	0.1	0.1	0.8	-0.0	0.4	0.0	-0.2	0.9	-0.0
Blood Red Count	0.1	0.7	2.2	-0.6	-1.5	-1.3	0.6	-0.9	-0.6
Height	0.1	1.1	3.0	1.6	0.1	-1.2	1.1	-1.7	0.9
Cardiovascular Disease	0.1	0.4	2.5	-0.2	0.3	0.2	1.6	0.2	0.7
Lung FEV1/FVC ratio	0.1	0.3	0.6	0.6	0.1	-0.5	0.7	-0.7	-0.6
Lung FVC	0.1	0.4	2.2	0.7	0.1	-0.4	0.7	-0.1	1.5
Neuroticism	0.1	0.2	0.8	-0.3	-0.4	0.2	-0.9	0.4	-0.7
Hair Pigment	0.1	2.1	9.8	0.7	1.3	0.8	1.9	1.0	3.1
Tanning	0.1	1.1	4.4	-1.0	0.6	1.5	-0.4	2.1	-0.6
Sitting height	0.1	0.4	1.1	-0.7	-0.9	-1.1	0.4	-0.9	-0.4
Neuroticism score	0.1	0.3	1.5	1.2	0.7	0.3	0.1	0.0	0.4
Hip circumference	0.1	0.6	3.5	-0.4	-0.4	-0.5	1.9	-0.6	0.6
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	-0.2	0.1	0.4	-0.8	0.7	-0.6
Standing height	0.1	0.7	2.6	0.9	-0.3	-1.3	0.7	-1.6	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.5	0.4	0.5	0.2	0.4	-0.3	0.7
Arm fat-free mass (right)	0.1	0.7	3.5	0.6	0.8	0.6	1.9	0.2	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.6	0.6	0.1	0.0	-0.2	-0.1	0.8
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.6	-0.1	0.3	0.2	-0.8	0.6	-0.2
Arm predicted mass (right)	0.1	0.6	3.7	0.6	0.7	0.4	1.9	-0.0	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.6	-0.8	-0.3	-0.0	-0.6	0.3	-0.0
Smoking status: Previous	0.1	0.2	0.6	-0.6	0.0	0.5	0.1	0.7	-0.3
Medication: Lisinopril	0.1	0.2	0.6	0.3	0.7	0.2	0.8	-0.0	-0.2
Ever smoked	0.1	0.2	0.6	-0.4	0.1	0.5	-0.2	0.6	-0.8
Arm fat-free mass (left)	0.1	0.7	3.1	0.8	1.1	0.7	1.8	-0.1	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	1.0	0.1	-0.4	0.0	-0.0	-0.1	-1.0
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.3	0.0	-0.3	-0.4	-0.3	-0.5
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Number of live births	0.0	0.1	0.1	0.2	0.2	-0.1	-0.4	-0.4	-0.2
Gout (self-reported)	0.0	0.0	0.3	-0.5	-0.2	0.0	0.1	-0.1	-0.0
Medication: Amlodipine	0.0	0.1	0.4	-0.6	-0.0	-0.1	-0.1	0.2	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	-0.1	0.1	0.1	0.1	0.2	-0.3
Diastolic blood pressure, automated reading	0.0	0.0	0.1	-0.2	0.1	-0.2	0.3	0.1	0.2

Hub : Genes

ALG10B

Models

Trait associations