Hub : Genes

CPNE8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0780	0.0270	1.8e-08	0.038	0.064	0.053	0.059	0.042	1.6e-05	3.2e-08	4.7e-07	9.1e-08	7.4e-06
2	GTEx	Colon Transverse	0.1530	0.0620	1.5e-04	0.039	NA	0.060	NA	0.062	6.0e-03	NA	7.8e-04	NA	6.9e-04
3	GTEx	Esophagus Mucosa	0.1750	0.0690	9.6e-06	0.000	NA	0.012	NA	0.042	3.1e-01	NA	4.8e-02	NA	7.8e-04
4	GTEx	Pituitary	0.2690	0.1120	2.8e-03	-0.006	NA	0.010	NA	0.006	4.7e-01	NA	1.8e-01	NA	2.2e-01
5	GTEx	Stomach	0.1100	0.0560	7.7e-03	0.079	NA	0.008	NA	0.010	1.2e-04	NA	1.3e-01	NA	1.0e-01
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0256	0.0146	9.1e-03	0.026	0.011	0.023	NA	0.027	5.3e-04	1.6e-02	1.2e-03	NA	4.6e-04
7	TCGA	Prostate Adenocarcinoma	0.0319	0.0167	2.4e-03	0.023	0.026	0.022	NA	0.023	1.5e-03	7.9e-04	1.9e-03	NA	1.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.1	1.7	6.5	0.4	-0.3	1.3	2.6	-0.6	1.7	0.6
Bipolar Disorder or Schizophrenia	1.5	3.6	10.4	-0.5	-2.0	3.2	2.4	0.5	1.7	1.3
Depressed Affect (Nagel 2018)	0.6	1.3	3.0	-1.7	-1.4	0.1	-0.5	1.6	0.9	-0.2
Depression (Nagel 2018)	0.5	0.7	3.9	-0.1	-0.4	0.2	0.6	2.0	0.4	0.3
Intelligence (Savage-Jansen 2018)	1.1	3.2	11.8	-1.2	0.1	-3.4	-1.4	0.8	-0.8	-2.4
Neuroticism (Nagel 2018)	0.1	0.2	0.4	-0.4	-0.2	0.3	-0.6	0.1	0.6	0.1
Schizophrenia (2018)	1.3	2.7	8.7	-1.1	-2.2	3.0	0.7	1.1	0.9	1.2
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	-0.6	-0.2	0.2	-0.9	0.6	-1.0	-1.1
Worry (Nagel 2018)	0.1	0.3	1.5	0.1	0.3	0.3	0.4	0.1	1.2	0.1
Alzheimer’s Disease (in mother)	0.3	0.4	1.8	0.4	-0.0	0.4	0.3	-0.7	1.3	0.2
Alzheimer’s Disease (in father)	0.5	0.5	1.2	0.6	-0.7	0.7	-1.1	0.1	-0.9	0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	0.2	-0.8	0.6	-0.4	0.0	0.8	-0.2
Crohns Disease (2017)	0.1	0.2	0.4	0.1	0.6	0.6	0.1	-0.4	0.7	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.7	0.1	0.5	-0.4	-0.7	-0.4	0.3
Ulcerative Colitis (UC)	0.3	0.6	1.0	-0.9	-0.3	1.0	-0.6	-0.9	-1.0	0.7
Major Depression (MDD)	3.1	3.8	6.9	-2.1	-2.6	1.6	1.8	1.2	1.0	2.6
Reaction Time	3.4	6.5	14.6	-2.1	-2.2	1.6	3.2	3.8	2.3	1.9
Verbal and Numeric Reasoning (VNR)	0.9	2.2	9.3	-1.5	-0.1	-3.0	-1.2	0.8	-0.4	-1.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.8	1.0	2.9	-0.6	-1.7	0.4	0.7	1.7	0.5	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.8	1.1	4.6	-0.8	0.1	-2.1	-1.2	1.0	-0.2	0.3
Bipolar Disorder (2011)	1.9	1.9	3.9	-0.5	-0.5	2.0	1.9	0.7	1.6	1.5
Body Mass Index (BMI) (2010)	0.9	1.2	3.6	1.2	0.6	-0.5	-0.4	-1.9	-1.3	-1.0
Coronary Artery Disease (CAD)	0.5	0.6	1.8	-0.9	-0.6	0.7	-0.1	0.5	-1.4	-0.9
Crohns Disease (2012)	0.5	0.8	2.0	0.8	0.8	-1.0	-1.4	-0.1	-0.8	-1.0
Mean Putamen Volume	1.1	1.2	4.9	-0.2	-0.9	0.6	-2.2	-1.0	-0.9	0.7
Fasting Glucose	0.4	0.4	1.4	-0.5	-0.5	0.1	-0.7	1.2	-0.6	-0.4
HbA1C	0.8	0.8	1.7	0.7	1.2	-1.3	-0.5	-1.2	0.2	0.7
HDL Cholesterol	0.2	0.4	1.7	0.3	-0.2	-0.3	-1.3	-0.5	-0.7	0.2
LDL Cholesterol	1.3	2.1	5.2	0.6	0.4	2.0	1.3	0.1	2.3	1.8
Lupus	3.6	5.4	9.0	-2.3	-2.8	1.8	3.0	1.8	2.3	1.9
Neuroticism (2016)	1.1	1.6	4.4	-0.6	-0.8	1.6	1.2	0.8	2.1	1.1
Primary Biliary Cirrhosis	0.3	0.4	1.3	0.0	0.2	0.1	1.2	-0.9	-0.6	-0.0
Rheumatoid Arthritis	0.5	0.7	2.0	-0.2	-0.9	1.4	-0.7	-1.1	0.0	0.5
Schizophrenia (2014)	2.1	4.7	9.3	-2.0	-3.0	3.0	2.0	1.1	1.7	1.5
Triglycerides	2.9	4.8	8.8	-1.3	-0.8	2.8	3.0	0.2	2.6	2.7
Type 2 Diabetes (T2D) (2012)	3.7	4.2	11.3	-3.4	-3.0	-0.3	0.9	2.8	-0.1	0.6
Ulcerative Colitis	0.7	1.1	2.2	-1.5	-1.1	1.4	-0.9	0.6	-0.9	0.7
Blood Eosinophil Count	0.4	2.7	7.7	-0.7	-0.8	2.2	0.9	1.8	1.3	2.8
Blood Platelet Count	0.4	4.9	11.6	-3.4	-2.8	0.9	1.0	1.5	0.6	3.2
Blood Red Count	0.1	1.0	3.0	-1.7	-0.8	-1.3	0.2	0.1	0.4	1.2
Blood White Count	0.4	2.7	8.2	-2.3	-2.0	0.3	0.7	0.8	-0.4	2.9
Heel T-Score	1.5	11.6	16.4	-2.8	-2.3	4.0	4.0	2.2	4.0	3.8
BMI	0.1	0.8	3.4	-0.3	-0.3	-0.2	-1.0	-0.5	-1.8	1.0
Height	0.2	3.2	6.9	-1.6	-2.6	-1.0	0.7	2.6	-1.8	-1.3
Waist Hip Ratio (WHR)	1.0	4.3	9.1	-2.8	-2.6	0.6	-0.2	3.0	1.2	2.1
Systolic Blood Pressure	0.2	1.1	2.8	-1.1	-0.6	-0.8	-1.7	0.5	-0.3	1.6
Smoking Status	1.4	3.3	7.6	-0.3	-0.9	1.8	2.8	-1.3	1.7	2.6
Allergy or Eczema	0.4	0.9	2.0	-0.5	-1.0	-1.4	-0.2	1.4	-1.1	-0.5
Cardiovascular Disease	0.1	0.4	1.1	-0.7	-0.7	-0.1	-0.3	-0.9	-1.0	0.3
Hypothyroidism (self reported)	0.2	0.5	1.2	-0.9	-0.1	-0.4	0.5	1.1	1.0	0.5
Respiratory disease	2.5	5.5	12.3	-2.3	-3.5	2.1	2.5	1.1	1.2	2.8
Type 2 Diabetes (T2D) (2018)	1.6	2.9	4.9	-2.0	-1.8	1.5	2.2	1.5	1.6	1.2
Lung FEV1/FVC ratio	0.1	0.6	1.7	-0.8	-0.9	-0.7	-1.3	0.5	-0.1	0.4
Lung FVC	0.3	1.3	3.7	0.1	-1.2	-1.4	0.2	1.1	-1.9	-0.8
Neuroticism	0.2	0.4	1.9	0.1	-0.4	0.7	-0.0	-0.6	1.4	0.3
Chronotype (morning person)	12.7	29.4	93.6	6.7	8.1	0.4	0.5	-9.7	1.1	-0.3
Hair Pigment	0.1	2.1	8.5	0.0	0.2	1.3	-1.7	-1.1	-2.9	-0.6
Tanning	0.0	0.5	1.7	0.4	0.1	0.5	0.0	-1.3	0.9	0.3
Hand grip strength (left)	0.4	1.1	2.7	-1.0	-1.3	0.1	-0.8	1.6	-1.2	-0.4
Number of treatments/medications taken	0.6	1.2	3.8	-0.7	-0.1	0.4	1.6	-0.8	0.7	2.0
Average weekly spirits intake	0.8	1.0	2.5	1.0	1.6	-0.4	0.8	-1.3	0.6	0.4
Sensitivity / hurt feelings	1.3	2.2	5.5	1.7	2.1	0.9	0.1	-2.4	1.1	0.8
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.9	0.7	0.7	-0.7	-0.9	0.9	-0.2	-0.5
Hearing difficulty/problems: Yes	0.4	0.6	1.9	0.1	0.1	0.0	0.9	-1.4	0.6	1.0
Relative age of first facial hair	0.8	1.7	5.0	0.8	-0.5	-0.5	-2.1	2.2	0.1	-0.9
Other serious medical condition/disability diagnosed by doctor	2.3	2.9	6.6	-0.7	-1.1	2.2	0.9	1.8	1.9	2.6
Ever used hormone-replacement therapy (HRT)	1.1	1.4	5.3	-0.5	-0.0	1.8	1.0	-0.5	0.3	2.3
Ever had hysterectomy (womb removed)	0.6	0.7	2.8	0.8	0.5	0.3	-0.3	-1.7	-0.4	0.9
Systolic blood pressure, automated reading	0.6	1.7	5.5	-1.0	-1.2	0.4	-1.4	1.3	-0.4	2.4
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	4.5	-1.3	-1.4	2.1	-0.1	0.8	0.6	1.8
Angina	0.8	1.0	3.9	1.1	0.6	0.8	-0.3	-2.0	-0.9	-0.2
Medication for hormone replacement therapy	0.7	0.8	4.2	0.1	0.5	1.0	0.2	-0.3	-0.4	2.1
Vitamin and mineral supplements	0.8	1.0	3.7	-0.2	-1.1	-1.0	-0.8	-0.8	-0.5	-1.9
Supplements: Zinc	1.0	1.1	3.5	-0.0	0.6	1.1	0.8	-0.0	1.3	1.9
Medication: Co-codamol	0.7	0.8	2.6	-0.9	-0.5	1.2	-0.1	1.6	0.1	0.7
Medication: Metformin	1.0	1.3	3.2	-1.4	-1.1	0.8	1.1	0.4	0.9	1.8
Diabetes (father)	0.4	0.5	1.0	0.3	0.7	0.8	1.0	-0.9	-0.4	0.4
Diabetes (mother)	3.1	4.0	16.9	-0.8	-0.7	4.1	-0.4	1.8	2.1	1.5
Severe depression (siblings)	1.1	1.2	2.7	-1.0	-1.6	1.3	-0.2	0.5	0.5	1.6
Pack years adult smoking proportion	1.3	2.0	4.3	-0.2	0.8	2.1	2.0	-0.3	1.8	1.3
Impedance of leg (right)	0.1	0.6	1.6	-0.5	-0.5	1.3	-0.3	1.3	0.3	-0.5
Leg fat-free mass (left)	0.3	1.4	3.7	-1.2	-1.3	-1.9	0.0	0.5	-1.6	-0.5
Trunk fat percentage	0.8	3.1	8.4	-2.9	-2.6	1.1	0.1	1.8	-0.2	1.6
Hand grip strength (right)	1.0	2.7	4.3	-1.4	-2.0	-1.2	-0.5	1.9	-2.1	-1.8
Townsend deprivation index at recruitment	0.4	0.6	1.5	0.2	0.0	1.2	0.2	-0.8	1.1	0.8
Current tobacco smoking	0.6	1.0	1.9	0.3	0.8	1.0	1.1	-1.4	1.1	1.0
Average weekly fortified wine intake	2.0	2.3	4.9	2.2	1.7	-1.3	-1.1	-1.8	-1.0	-1.2
Maternal smoking around birth	0.4	0.5	2.2	0.8	-0.0	1.5	0.5	-0.4	-0.4	0.5
Fed-up feelings	0.7	1.2	3.5	-1.9	-1.5	0.1	0.1	1.3	0.4	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	5.6	0.7	0.3	0.0	-1.2	2.4	-0.7	-0.3
Relative age voice broke	0.6	0.9	2.1	1.4	0.2	-1.0	-0.4	1.2	0.0	-1.3
Taking other prescription medications	2.5	3.8	13.0	-1.4	-1.0	2.4	1.6	0.7	1.5	3.6
Age when periods started (menarche)	0.9	2.2	9.1	-0.1	-1.1	-0.1	-0.6	3.0	2.0	-0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.3	-0.3	-0.9	0.6	1.2	0.8	0.0	0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	6.9	-1.8	-2.4	0.3	0.4	2.6	0.6	0.6
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.4	0.9	1.8	-1.2	0.7	-0.1	1.7	-1.2
Qualifications: CSEs or equivalent	1.1	1.4	4.9	0.7	0.7	-1.0	-0.7	-0.6	-1.5	-2.2
Serious illness, injury or assault to yourself	1.1	1.4	4.2	-0.6	-1.1	0.8	0.9	1.4	0.7	2.0
High blood pressure	0.2	0.4	1.1	-0.0	-0.2	-1.1	-0.6	-0.7	-1.0	-0.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	5.0	-0.5	-0.2	-2.2	-0.1	1.0	-0.7	-0.8
Multivitamins +/- minerals	0.8	1.0	3.5	-0.0	0.9	0.9	0.6	0.9	0.9	1.9
Stomach or abdominal pain in last month	0.5	0.7	2.9	0.7	-0.2	-0.3	0.2	0.8	1.7	0.6
Supplements: Glucosamine	1.6	2.0	8.0	0.8	1.4	0.2	0.9	-0.7	1.5	2.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.5	0.4	0.2	-1.2	-0.0	0.4	0.5	-0.6
Medication: Atenolol	0.9	1.1	2.5	1.2	1.6	-0.8	-0.9	-1.1	-0.8	-0.7
Medication: Levothyroxine sodium	0.2	0.4	0.9	-0.3	-0.1	-0.8	0.5	1.0	0.4	0.6
Sitting height	0.2	1.5	4.0	-1.5	-1.1	-0.7	2.0	1.7	-0.1	0.5
Chronic bronchitis/emphysema (father)	0.6	0.7	2.3	0.1	0.5	1.0	0.9	0.5	0.4	1.5
High blood pressure (mother)	0.8	1.1	3.5	-0.8	-0.1	-1.4	-1.9	1.0	-1.0	-0.1
Body mass index (BMI)	0.1	0.3	1.3	-0.4	0.1	0.2	-0.2	-0.4	-0.6	1.1
Impedance of leg (left)	0.2	1.1	3.6	-0.9	-1.2	1.9	0.1	1.3	0.4	0.1
Leg predicted mass (left)	0.3	1.4	3.5	-1.2	-1.3	-1.9	-0.0	0.5	-1.5	-0.5
Trunk fat mass	0.5	2.2	6.2	-2.5	-2.2	0.6	0.1	1.5	-0.5	1.4
Waist circumference	0.5	1.7	4.7	-2.2	-1.5	0.5	0.5	0.9	0.1	1.9
Number of incorrect matches in round	2.7	4.4	11.9	2.8	3.5	0.8	-1.7	-2.7	0.0	-0.4
Past tobacco smoking	0.4	0.8	2.3	-0.8	-0.2	-1.1	-0.5	1.0	-0.4	-1.5
Alcohol usually taken with meals	0.2	0.3	0.6	-0.7	-0.8	-0.6	0.1	-0.3	0.3	0.6
Nervous feelings	0.6	1.2	3.1	-1.8	-1.5	0.9	-0.3	0.3	0.8	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	2.5	0.1	-0.3	-0.2	-0.3	1.6	-0.2	-0.2
Hearing difficulty/problems with background noise	0.5	0.7	2.1	-0.4	0.2	0.4	1.5	-0.9	0.8	1.0
Hair/balding pattern: Pattern 2	0.5	0.6	3.0	-0.7	-0.1	0.5	-0.0	1.7	0.1	-0.8
Had menopause	1.2	1.5	4.0	0.7	2.0	0.3	1.2	-0.3	1.2	1.8
Had other major operations	3.6	4.3	11.1	-0.7	-0.2	3.3	1.4	1.3	2.5	3.0
Forced vital capacity (FVC)	0.4	1.7	3.4	-0.5	-1.4	-1.0	-0.3	1.6	-1.9	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	9.3	-1.8	-2.3	0.8	1.1	3.1	0.4	1.1
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	5.8	-0.6	-0.4	0.0	1.1	2.4	1.5	0.7
Qualifications: None of the above	0.4	0.9	1.9	1.3	0.3	1.2	0.5	-1.4	1.1	0.1
Financial difficulties in last 2 years	0.4	0.5	2.2	0.2	0.1	0.4	-0.3	1.5	-0.5	0.9
Mouth/teeth dental problems	0.7	1.1	2.5	0.4	0.7	-1.3	0.9	-1.6	-0.4	-1.3
Heart attack	0.5	0.7	2.0	0.8	0.9	0.4	-0.5	-1.4	-0.6	0.6
Allergy	0.7	1.5	3.1	1.3	1.8	1.7	-1.0	-1.4	-0.3	0.1
Pain all over the body in last month	1.1	1.2	3.4	-0.5	-0.6	0.2	1.9	1.4	0.3	1.4
Diabetes (self-reported)	0.5	0.8	2.5	-0.9	-0.6	0.1	1.6	1.2	0.4	0.7
Hayfever/allergic rhinitis (self-reported)	1.2	1.5	3.3	-1.5	-1.8	-1.0	-1.4	0.7	-0.6	-1.2
Medication: Ramipril	1.3	1.7	7.0	1.3	1.0	0.9	0.4	-2.6	0.7	0.8
Medication: Simvastatin	1.8	2.6	6.1	-0.8	-0.4	2.1	1.3	-0.6	2.2	2.5
Fluid intelligence score	1.3	2.7	14.7	-0.8	0.3	-3.8	-1.1	0.5	-0.5	-1.4
Illnesses of siblings	1.2	1.7	3.2	1.8	1.4	-0.6	0.1	-1.6	0.5	-1.8
Neuroticism score	0.2	0.4	1.9	0.2	-0.2	-0.6	-1.4	-0.6	0.1	-0.6
Weight	0.1	0.7	1.6	-1.2	-0.9	-0.5	0.4	0.6	-1.0	0.6
Impedance of arm (right)	1.0	4.5	13.1	-3.2	-3.6	0.2	-0.7	2.7	-0.7	-0.3
Arm fat percentage (right)	0.5	2.1	5.6	-2.4	-2.2	0.6	-0.8	1.2	-1.1	1.0
Trunk fat-free mass	0.2	1.0	2.7	0.7	0.5	-1.5	-0.4	0.1	-1.6	-1.0
Hip circumference	0.1	0.4	1.1	-1.0	-0.5	-0.1	0.4	-0.1	-0.6	1.1
Time employed in main current job	0.9	1.0	3.3	0.9	0.8	-0.9	0.4	-1.2	0.3	-1.8
Alcohol intake versus 10 years previously	1.9	2.8	9.7	-1.8	-1.7	1.4	1.0	3.1	0.3	0.7
Father’s age at death	0.4	0.5	1.3	-0.4	0.0	0.7	-1.0	0.5	0.6	-1.2
Worrier / anxious feelings	0.4	0.7	1.8	1.0	1.0	0.8	-0.7	-1.3	0.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.5	9.9	-1.4	-1.8	0.6	-0.1	3.1	0.7	1.3
Falls in the last year	0.9	1.2	3.6	1.3	1.9	-0.6	-0.8	0.3	-0.4	-1.4
Hair/balding pattern: Pattern 3	1.1	1.6	4.7	1.3	1.8	0.8	-0.7	-2.2	0.6	-0.3
Number of live births	0.5	0.7	2.5	0.9	0.4	1.6	-1.0	0.3	0.1	-0.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	5.4	-0.4	-1.4	-1.6	-1.2	1.5	-2.3	-1.9
Pulse rate	3.5	5.8	28.5	2.6	2.1	0.2	-0.2	-5.3	1.2	-0.3
Happiness	0.6	0.8	2.1	0.4	0.8	0.3	-0.8	1.4	1.3	-0.5
Noisy workplace	0.6	0.7	1.7	1.1	1.0	1.3	-0.4	0.3	-0.5	-0.7
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.6	-1.9	-1.6	-1.7	-0.4	1.7	-0.3	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	3.9	0.8	0.6	-2.0	-1.8	0.4	-1.7	-1.1
Mouth/teeth dental problems: Dentures	0.1	0.2	1.1	0.1	0.0	0.1	-0.3	-0.3	1.0	0.0
Asthma	1.8	3.5	7.9	-1.2	-2.1	1.5	2.8	0.4	1.8	2.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.9	-0.2	-0.0	-1.0	-0.8	0.5	-0.5	-0.6
Medication: Cholesterol lowering	1.5	2.3	9.7	0.5	-0.2	3.1	0.1	-1.4	0.2	2.1
Depression (self-reported)	0.5	0.6	1.2	-1.1	-1.1	-0.9	-0.3	1.1	-0.2	-0.1
Medication: Lansoprazole	0.8	0.9	1.4	-0.5	-1.0	-0.9	-1.1	-0.8	-1.2	1.0
Prospective memory result	0.8	1.0	2.5	-0.5	-0.4	1.6	0.7	-1.5	-0.8	0.6
Lung cancer (father)	1.2	1.4	3.2	1.8	1.1	-0.4	-1.1	-0.7	-1.5	-1.2
Illnesses of mother	0.8	1.0	3.1	1.4	0.6	0.1	0.9	-1.8	0.3	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	6.2	0.7	-0.7	-2.5	-1.8	0.5	-2.1	-2.5
Pulse wave Arterial Stiffness index	1.4	1.7	4.8	0.1	-0.4	1.9	0.4	-0.8	1.5	2.2
Impedance of arm (left)	1.1	4.9	13.5	-3.5	-3.7	-0.3	-0.3	2.8	-0.7	-0.4
Arm fat mass (right)	0.2	0.9	2.4	-1.5	-1.2	0.1	-0.3	0.7	-1.0	0.9
Trunk predicted mass	0.2	1.0	3.0	0.6	0.4	-1.6	-0.4	0.1	-1.7	-1.1
Standing height	0.3	2.5	5.6	-1.7	-2.2	-1.2	1.1	2.4	-0.8	-0.9
Length of working week for main job	1.4	1.5	3.2	1.3	1.4	-1.8	-1.4	-0.8	-0.2	-1.0
Exposure to tobacco smoke at home	1.5	1.7	2.8	1.5	1.3	1.7	1.4	0.1	1.4	1.1
Breastfed as a baby	0.4	0.5	1.8	-0.6	-0.5	0.4	1.3	0.6	0.0	0.7
Tense / ‘highly strung’	0.3	0.5	2.3	-0.3	-0.1	0.5	-0.4	1.5	0.1	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.7	8.5	-1.6	-1.8	1.5	0.2	2.9	0.7	1.2
Hair/balding pattern: Pattern 4	0.2	0.6	1.4	0.1	0.2	-0.1	-1.1	1.1	-1.2	-0.4
Birth weight of first child	0.6	1.1	5.1	-0.7	-1.0	-0.1	0.4	2.3	0.9	-0.2
Peak expiratory flow (PEF)	0.7	1.6	5.3	0.5	-0.2	-0.8	-0.9	0.8	-2.0	-2.3
Pulse wave reflection index	0.8	1.0	2.2	-0.3	-1.0	1.1	-1.2	0.3	-1.5	1.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.1	1.5	1.1	-0.1	0.4	0.7	-0.4	-0.4
Loud music exposure frequency	1.2	1.3	4.0	0.8	0.3	2.0	0.8	-0.8	-0.7	1.6
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	5.8	-0.2	0.4	-2.2	0.0	0.8	-0.9	-2.4
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.7	0.3	0.0	0.7	-1.6	0.8	-0.7	1.3
Blood clot in the leg (DVT)	0.6	0.8	1.9	-0.6	-1.4	-0.4	-0.4	1.4	-0.9	-0.6
Medication: Paracetamol	0.6	0.9	2.1	-0.4	-1.2	1.5	0.4	0.6	-1.0	1.0
Headache pain in last month	0.3	0.6	1.2	0.1	-1.1	0.9	0.3	0.8	1.1	0.3
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	5.4	-1.2	-0.7	-2.1	-0.3	2.3	0.2	-1.7
Glaucoma (self-reported)	4.1	4.8	10.5	3.2	2.9	-0.8	-2.5	-2.2	0.1	-1.9
Gout (self-reported)	0.3	0.5	1.0	0.0	-0.4	0.6	1.0	0.8	0.5	0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.5	-0.4	0.5	0.6	1.3	0.8	1.5	1.6
Medication: Amlodipine	0.1	0.1	0.2	-0.5	0.4	0.2	0.2	0.1	-0.4	0.5
Medication: Ventolin 100micrograms inhaler	1.4	1.7	4.7	0.1	0.0	0.9	1.8	-1.4	1.1	2.2
Birth weight	1.1	2.5	10.6	-0.8	-0.5	1.0	0.8	3.2	1.9	0.8
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.1	-0.4	0.4	1.4	1.4	1.5	0.2	0.5
High blood pressure (siblings)	1.3	1.8	4.5	-2.1	-1.5	-0.5	-0.2	1.8	-0.2	1.5
Forced vital capacity (FVC), Best measure	0.6	2.2	5.7	1.0	-0.4	-2.2	-0.9	0.3	-1.8	-2.4
Body fat percentage	0.6	2.3	6.4	-2.5	-2.1	1.2	-0.2	1.1	-0.3	1.4
Leg fat percentage (right)	0.3	1.0	2.3	-1.5	-0.8	1.4	0.1	0.1	0.1	1.4
Arm fat-free mass (right)	0.1	0.4	1.3	0.4	0.4	-1.2	0.7	-0.2	-0.8	-0.2
Exposure to tobacco smoke outside home	1.0	1.3	3.1	-0.3	0.2	-0.4	-1.6	1.8	-0.9	-1.6
Comparative body size at age 10	1.1	2.9	11.4	1.8	1.9	1.1	0.9	-3.4	-0.5	0.2
Number of full brothers	1.0	1.3	3.9	-2.0	-1.8	-0.7	-0.6	0.9	0.2	0.5
Worry too long after embarrassment	1.7	2.8	7.1	1.3	0.5	-1.6	-2.7	-2.2	-0.8	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	7.4	-2.0	-1.9	0.3	1.4	2.7	0.7	0.6
Wheeze or whistling in the chest in last year	1.0	1.9	6.0	-0.1	0.6	1.5	1.4	-0.0	1.5	2.5
Number of children fathered	1.3	1.4	3.1	-0.8	-0.8	1.7	1.3	1.8	0.7	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.0	0.7	-0.8	0.2	-0.3	-0.4	-1.0	-0.6
Age at first live birth	0.5	0.8	3.0	-1.3	-1.7	-0.7	-0.6	0.1	-0.3	0.4
Pulse wave peak to peak time	1.5	1.7	5.2	-0.0	0.3	-1.9	-0.4	1.0	-1.5	-2.3
Health satisfaction	2.4	3.2	8.0	-0.8	-0.2	2.2	0.8	2.2	2.8	1.8
Shortness of breath walking on level ground	0.5	0.6	1.8	-0.0	1.3	-0.0	0.1	-0.1	1.1	1.1
Qualifications: College or University degree	0.5	1.5	3.4	-1.9	-1.7	0.3	-0.1	1.2	0.3	1.5
Eye problems/disorders: None of the above	3.4	4.0	10.4	-3.1	-3.2	0.3	1.8	1.5	0.3	1.4
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	-0.0	-0.0	0.3	-0.8	-0.6	0.5	-0.1
Emphysema/chronic bronchitis	0.4	0.4	0.8	-0.4	-0.3	0.9	0.6	-0.0	0.8	0.9
Medication for pain relief, constipation, heartburn	0.5	0.8	3.1	0.1	0.1	-1.4	-0.5	0.2	0.6	-1.8
Neck or shoulder pain in last month	0.9	1.3	3.9	-0.7	-0.5	1.5	-0.3	0.8	1.2	2.0
Medication: Blood pressure	0.7	1.3	4.3	1.4	0.9	0.3	0.7	-2.1	-0.8	0.7
Angina (self-reported)	0.8	1.1	3.4	1.3	1.0	0.5	-0.4	-1.9	-1.0	-0.1
Migraine (self-reported)	2.0	2.5	7.5	0.8	0.6	-2.1	-2.7	-0.3	-0.7	-1.9
Medication: Ibuprofen	0.3	0.3	1.1	-0.6	-0.2	-1.0	-0.5	0.1	-0.6	-0.6
Medication: Allopurinol	0.6	0.9	4.3	0.3	-0.2	0.8	2.1	0.2	0.7	0.7
Medication: Omeprazole	5.1	6.1	17.7	-1.9	-1.3	4.2	0.7	1.2	2.2	3.6
Medication: Seretide 50 evohaler	1.4	1.6	6.2	0.1	-0.7	1.1	2.5	-0.5	0.7	1.7
Mean time to correctly identify matches	3.6	6.9	12.1	-2.1	-2.4	2.4	3.0	3.5	2.4	2.5
Heart disease (mother)	0.3	0.4	1.1	-0.5	-0.1	1.0	-0.4	-0.1	0.0	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.2	-0.1	-0.3	1.1	-0.3	-1.5	-0.1	0.3
Whole body fat mass	0.3	1.4	4.0	-2.0	-1.7	0.6	-0.1	1.0	-0.6	1.0
Leg fat mass (right)	0.2	0.7	2.4	-1.5	-1.0	0.6	0.2	0.1	-0.4	1.0
Arm predicted mass (right)	0.1	0.3	1.2	0.2	0.3	-1.1	0.7	-0.1	-0.8	-0.2
Pulse rate, automated reading	4.0	12.8	60.3	3.2	2.9	-2.0	-0.0	-7.8	0.8	-2.3
Alcohol intake frequency.	1.2	2.9	11.6	-2.2	-1.6	-0.8	-0.3	3.4	-0.5	-0.3
Comparative height size at age 10	0.2	1.4	3.0	0.9	1.7	-0.4	1.3	-1.6	-0.5	-1.1
Number of full sisters	0.8	1.0	3.8	-0.4	-1.2	0.7	-2.0	1.1	-0.3	-0.1
Suffer from ‘nerves’	0.5	0.8	2.8	0.1	-0.3	-1.7	-0.9	0.0	-1.2	-0.8
Overall health rating	2.0	4.2	9.0	-1.7	-1.3	2.8	0.5	3.0	1.6	2.3
Chest pain or discomfort	0.3	0.4	1.1	0.6	0.1	0.9	-0.4	-0.5	1.0	-0.1
Had major operations	1.0	1.2	3.2	-0.3	-0.2	1.0	1.8	1.5	0.7	0.9
Age at last live birth	0.2	0.3	0.9	0.1	-0.5	-0.6	0.3	0.9	0.6	0.1
Family relationship satisfaction	1.8	2.2	6.4	1.5	2.5	-0.7	-1.1	-0.4	-1.1	-1.9
Leg pain on walking	0.6	0.8	2.9	0.2	-0.1	1.7	-0.3	0.9	1.1	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.8	0.2	0.4	-0.4	-0.3	0.4	-0.8	-0.9
Commuting to job workplace: Car/motor vehicle	2.3	2.6	6.7	1.8	0.6	-0.2	-2.0	-1.7	-2.6	-0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.6	-0.4	-0.2	-0.2	0.4	-0.9	0.0	-1.6
Medication: Aspirin	1.4	1.9	7.3	0.2	0.8	1.4	1.7	-0.1	0.2	2.7
Supplements: Vitamin C	1.0	1.2	2.6	-0.7	-0.1	0.8	1.6	1.5	0.4	1.5
Knee pain experienced in last month	0.9	1.4	2.4	-1.2	-0.5	1.5	-0.9	1.3	1.4	1.0
Hypertension (Self-reported)	0.2	0.6	1.7	0.2	0.0	-1.2	-0.7	-0.6	-1.3	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.8	0.6	0.7	0.9	0.1	-0.3	0.3	0.9
Illnesses of father: Heart disease	0.3	0.4	1.3	-1.0	-1.2	-0.5	0.3	0.2	-0.3	0.4
Illnesses of siblings: Diabetes	1.1	1.3	4.9	-0.6	-0.1	2.2	0.2	0.4	0.5	1.9
Smoking status: Previous	0.2	0.3	0.9	0.6	-0.1	0.4	-0.0	-0.7	-0.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	5.9	-0.2	-0.6	-0.5	-1.4	1.0	-2.4	-0.9
Whole body fat-free mass	0.1	0.8	2.5	-0.1	-0.3	-1.6	-0.0	0.2	-1.5	-0.6
Leg fat-free mass (right)	0.2	1.2	2.9	-1.2	-1.5	-1.7	0.4	0.4	-1.4	-0.2
Arm fat percentage (left)	0.5	2.1	6.1	-2.5	-2.1	0.3	-0.8	1.1	-1.2	0.8
Average weekly red wine intake	0.8	1.2	3.0	-0.6	-0.8	0.1	-1.0	-1.7	-1.3	1.3
Handedness (chirality/laterality): Left-handed	1.0	1.2	5.4	-0.2	0.2	0.0	1.2	0.6	1.1	2.3
Mood swings	0.4	0.7	2.3	-0.6	-0.7	0.5	-1.5	0.7	-0.5	0.7
Loneliness, isolation	0.8	1.1	2.3	-0.8	-0.6	-1.4	-1.5	0.7	-1.2	-1.0
Long-standing illness, disability or infirmity	1.5	2.3	5.1	-1.4	-1.0	1.7	1.0	1.3	1.4	2.3
Ever had bowel cancer screening	2.9	3.4	11.6	-1.3	-1.1	2.2	1.1	0.7	1.8	3.4
Diabetes diagnosed by doctor	0.7	1.2	2.4	-1.3	-0.4	0.3	1.4	1.5	0.9	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.4	-0.3	-0.4	-0.4	-0.8	1.2	0.1	-0.7
Friendships satisfaction	1.1	1.3	3.2	1.4	1.8	-1.2	-0.4	-0.3	0.6	-1.5
Qualifications: nursing, teaching	2.7	4.1	6.3	-1.1	-2.5	-1.2	-2.5	1.7	-2.4	-2.4
Commuting to job workplace: Walk	0.5	0.5	2.0	-0.6	0.9	-0.2	-0.2	1.4	0.7	-0.3
Eye problems/disorders: Cataract	1.8	2.1	5.7	2.1	2.4	-1.0	-0.7	-0.6	-0.7	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.1	0.4	0.1	1.4	-0.3	1.4	0.5	0.5
Medication for cholesterol	0.8	1.2	2.6	1.6	0.4	0.5	-1.3	-0.7	-1.1	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	1.6	0.0	-1.0	1.2	0.9	-0.8	-1.3	1.1
Back pain experienced in last month	3.6	5.2	11.4	-1.5	-1.1	2.2	2.6	0.8	3.4	3.1
Mineral and other dietary supplements	2.7	3.6	8.4	-1.4	-2.2	-1.6	-1.5	1.2	-1.9	-2.9
Breast cancer (self-reported)	0.4	0.4	1.0	0.3	0.4	0.4	1.0	-0.8	1.0	-0.2
Asthma (self-reported)	1.8	3.6	7.6	-1.3	-2.2	1.4	2.8	0.4	1.8	2.4
Osteoporosis (self-reported)	0.6	0.7	2.9	-0.3	-0.5	-1.7	-0.8	-0.3	-1.1	-0.3
Osteoarthritis (self-reported)	1.6	2.1	4.8	-0.4	-0.6	2.0	1.3	1.6	1.0	2.2
Medication: Aspirin	1.2	1.6	7.9	-0.5	0.4	1.2	1.3	0.2	0.0	2.8
Medication: Gliclazide	1.4	1.6	4.5	-2.1	-1.8	0.6	-1.5	1.1	-0.3	0.2
Illnesses of father: None of the above (group 1)	1.1	1.3	4.5	0.2	0.1	-1.0	-0.7	-1.0	1.5	-2.1
Smoking status: Current	0.7	1.1	2.3	0.2	0.7	0.8	1.5	-1.1	1.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	6.1	0.4	-0.1	-2.4	-1.8	1.0	-2.5	-2.1
Whole body water mass	0.1	0.7	2.7	-0.0	-0.2	-1.6	0.1	0.2	-1.4	-0.6
Leg predicted mass (right)	0.2	1.2	2.6	-1.2	-1.5	-1.6	0.4	0.4	-1.4	-0.2
Arm fat mass (left)	0.3	1.2	3.1	-1.8	-1.5	0.3	-0.3	1.0	-1.1	0.8
Number of self-reported non-cancer illnesses	0.9	1.6	3.8	-1.7	-2.0	0.9	-0.3	1.1	-0.1	1.6
Average weekly champagne plus white wine intake	1.3	1.7	5.1	1.7	1.0	-0.6	-1.5	-2.3	-0.7	-0.3
Miserableness	1.5	2.7	5.2	-1.2	-1.8	-1.0	-2.0	1.7	-1.1	-2.3
Guilty feelings	0.7	1.1	4.1	1.2	1.3	0.0	0.0	-2.0	-0.0	0.6
Wears glasses or contact lenses	2.2	2.5	6.8	-1.1	-0.6	2.6	-0.4	1.3	1.4	2.3
Ever taken oral contraceptive pill	1.1	1.2	3.1	1.1	1.8	0.5	-1.3	1.3	-0.5	-0.5
Hearing aid user	1.1	1.2	3.8	-0.6	-0.9	2.0	-0.0	-0.2	0.9	1.6
Mother’s age at death	1.0	1.2	2.7	-1.5	-1.3	-0.0	1.0	1.6	0.9	0.6
Financial situation satisfaction	0.3	0.4	1.3	0.6	0.7	0.1	0.2	-0.1	1.1	-0.9
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.1	-0.2	0.6	0.9	-1.4	-0.3	1.1	0.2
Commuting to job workplace: Public transport	1.2	1.4	3.7	-1.1	-0.2	-1.7	0.5	1.3	1.9	-0.3
Eye problems/disorders: Glaucoma	3.9	4.7	9.6	3.1	2.7	-0.4	-2.4	-2.2	0.2	-2.3
Medication: Blood pressure	0.5	1.0	4.7	-1.1	0.0	-2.2	0.0	1.0	-0.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.9	0.1	0.3	1.4	-0.6	-0.4	0.4	0.5
Supplements: Fish oil (including cod liver oil)	2.6	3.4	7.1	1.8	2.7	1.7	1.6	-1.2	1.5	2.1
High cholesterol (Self-reported)	1.6	2.8	5.8	-0.7	-0.8	2.1	1.9	-1.0	2.0	2.4
Medication: Bendroflumethiazide	1.9	3.0	8.6	-2.9	-2.4	0.2	1.4	0.8	0.6	1.8
Medication: Paracetamol	0.7	1.1	2.5	-1.2	-1.6	1.2	0.6	0.7	-0.6	1.0
Medication: Lisinopril	0.1	0.1	0.3	0.3	0.6	-0.6	-0.4	0.0	-0.2	0.2
Medication: Atorvastatin	1.5	1.8	5.2	-0.1	0.1	1.5	2.3	-0.9	1.1	1.8
Illnesses of father: High blood pressure	0.6	0.8	2.9	0.4	0.8	0.7	1.0	-0.5	0.1	1.7
Alcohol drinker status: Never	0.4	0.5	1.9	-0.3	0.2	-0.5	1.4	0.8	0.7	0.5
Ever smoked	0.3	0.5	1.4	1.2	0.8	0.7	0.2	-1.0	0.4	0.4
Basal metabolic rate	0.1	0.7	2.0	-0.5	-0.6	-1.3	-0.0	0.4	-1.4	-0.4
Leg fat percentage (left)	0.4	1.6	3.4	-1.6	-1.1	1.8	0.5	0.2	0.2	1.9
Arm fat-free mass (left)	0.1	0.3	0.5	0.5	0.6	-0.7	0.6	0.2	-0.7	-0.3
Number of operations (self-reported)	2.8	4.1	6.6	-1.0	-1.1	2.4	1.9	2.2	2.6	2.4
Average weekly beer plus cider intake	0.4	0.6	1.5	0.6	-0.0	0.7	-1.2	1.0	-0.0	-0.8
Irritability	0.4	0.6	1.8	-0.3	-0.7	-0.8	-1.3	0.8	-0.8	0.3
Risk taking	0.5	0.7	1.6	1.0	1.3	1.1	0.5	0.6	0.7	0.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	3.4	-1.9	-0.7	-0.4	0.0	0.2	0.8	0.1
Fractured/broken bones in last 5 years	0.8	1.0	3.6	0.5	0.1	-1.9	-1.1	-1.3	-0.3	-0.2
Age started oral contraceptive pill	0.9	1.2	3.2	0.0	1.1	-0.5	1.8	0.4	1.8	0.5
Diastolic blood pressure, automated reading	0.2	0.8	3.4	0.4	0.0	0.2	-1.8	-0.8	-0.5	1.0
Ever depressed for a whole week	0.9	1.1	2.5	-1.5	-0.8	-1.2	-0.6	1.6	0.7	-0.3
Unable to work because of sickness or disability	1.1	1.4	3.8	0.2	-0.2	1.9	0.1	1.5	-0.3	1.9
Commuting to job workplace: Cycle	1.0	1.2	3.3	-1.8	-1.1	0.4	1.0	0.7	1.3	0.7
Myopia	1.0	1.5	3.0	-1.3	-1.4	0.1	1.3	1.7	-0.2	1.5
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.3	-0.0	0.2	0.3	0.7	1.1	1.0	-0.3
Cholesterol lowering medication	2.0	2.9	7.8	-1.9	-0.9	0.4	2.8	0.3	2.1	1.9
Medication: Omeprazole (e.g. Zanprol)	3.8	4.6	10.8	-2.1	-1.3	3.3	-0.1	1.4	1.9	3.1
Pain experienced in last month	1.9	3.2	5.5	1.5	2.3	-2.1	-1.0	-0.1	-1.8	-2.3
Supplements: Calcium	0.8	0.8	3.1	-1.1	-0.1	-0.2	0.5	-0.2	1.1	1.8
Basal cell carcinoma (self-reported)	0.5	0.6	2.6	0.8	0.9	-0.1	-0.0	-1.6	0.1	-0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.3	0.9	1.1	0.4	-0.5	-1.5	-0.5	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.5	-0.5	-1.1	-0.2	-0.1	1.2	-0.7	-0.4
Heart disease (siblings)	1.2	1.5	3.7	-1.1	-1.3	1.9	-0.4	1.3	-0.2	1.5
Alcohol drinker status: Previous	0.4	0.5	1.4	-0.6	-1.2	0.9	-0.5	0.2	-0.8	0.4
Pack years of smoking	1.6	2.3	4.8	-0.3	0.8	2.2	2.0	-0.3	2.2	1.4
Impedance of whole body	0.7	3.5	8.6	-2.7	-2.9	1.0	0.3	2.7	0.2	-0.0
Leg fat mass (left)	0.2	0.9	2.5	-1.6	-1.1	0.8	0.5	0.1	-0.3	1.2
Arm predicted mass (left)	0.1	0.4	1.2	0.6	0.5	-0.9	0.2	0.2	-1.1	-0.2