Best TWAS P=4.59e-08 · Best GWAS P=5.29e-09 conditioned to 0.035
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | HECTD4 | 0.06 | 0.03 | lasso | 4 | 0.02 | 1.8e-02 | -4.8 | 5.3 | 1.0e-07 | -0.82 | 0.11 | 0.82 | FALSE |
| 2 | GTEx | Nerve Tibial | HECTD4 | 0.05 | 0.01 | enet | 6 | 0.01 | 3.6e-02 | -5.7 | 5.5 | 4.6e-08 | -0.90 | 0.03 | 0.92 | TRUE |
| 3 | GTEx | Skin Sun Exposed Lower leg | ALDH2 | 0.10 | 0.09 | enet | 13 | 0.13 | 6.7e-11 | -4.8 | 5.3 | 1.1e-07 | -0.86 | 0.06 | 0.94 | FALSE |
| 4 | GTEx | Testis | BRAP | 0.06 | 0.03 | enet | 13 | 0.01 | 8.7e-02 | -4.8 | -5.2 | 2.1e-07 | 0.79 | 0.12 | 0.73 | FALSE |