TWAS
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Models
Genes
Traits
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Traits
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Chronotype (morning person)
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chr12:120,242,845-121,660,787
Best TWAS P=2.85e-08 · Best GWAS P=3.4e-07 conditioned to 0.0512
120.2M
120.4M
120.6M
120.8M
121M
121.2M
121.4M
121.6M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Brain Lower Grade Glioma
COQ5
0.15
0.14
blup
56
0.15
6.3e-17
3.9
5.6
2.9e-08
-0.65
0.43
0.37
TRUE
2
The Cancer Genome Atlas
Bladder Urothelial Carcinoma
COQ5
0.05
0.01
blup
56
0.03
9.0e-04
3.8
5.4
6.8e-08
-0.69
0.06
0.39
FALSE
1
GTEx
Esophagus Mucosa
COQ5
0.30
0.20
lasso
8
0.22
4.9e-15
3.9
5.1
2.8e-07
-0.52
0.42
0.38
FALSE
4
The Cancer Genome Atlas
Lung Adenocarcinoma
TRIAP1
0.04
0.02
blup
44
0.02
1.8e-03
3.9
-5.1
3.1e-07
0.59
0.04
0.32
FALSE