TWAS hub - BRAP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.058	0.033	0.00100	0.026	NA	0.012	NA	0.012	0.024	NA	0.087	NA	0.0910
2	GTEx	Thyroid	0.070	0.036	0.00018	0.019	NA	0.025	NA	0.035	0.012	NA	0.005	NA	0.0011

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Eosinophil Count	83.4	642.3	818.0	-21.6	-28.6
Hypothyroidism (self reported)	50.3	115.4	158.8	-8.5	-12.6
Medication: Levothyroxine sodium	49.2	83.4	102.0	-8.1	-10.1
Blood White Count	42.8	317.5	404.0	-15.2	-20.1
Hypothyroidism/myxoedema (self-reported)	42.7	83.2	110.2	-7.5	-10.5
Systolic Blood Pressure	21.9	109.6	127.7	-9.6	-11.3
Reaction Time	20.0	38.2	43.8	-5.7	-6.6
Diastolic blood pressure, automated reading	19.5	60.5	76.6	-6.7	-8.8
Mean time to correctly identify matches	18.9	36.0	42.1	-5.5	-6.5
LDL Cholesterol	16.2	25.6	29.7	4.6	5.5
Blood Red Count	15.4	148.7	158.1	-11.8	-12.6
High blood pressure	15.4	43.1	46.9	-6.3	-6.8
Smoking status: Previous	14.8	22.1	24.5	-4.4	-5.0
Cardiovascular Disease	14.4	47.6	53.5	-6.5	-7.3
Coronary Artery Disease (CAD)	14.3	17.1	20.2	-3.7	-4.5
Systolic blood pressure, automated reading	14.1	41.0	47.6	-5.9	-6.9
Vascular/heart problems diagnosed by doctor	13.6	37.2	41.6	5.7	6.5
Medication: Atenolol	13.4	16.8	22.5	-3.3	-4.7
Birth weight of first child	13.2	24.0	29.7	4.3	5.4
Medication: Blood pressure	13.2	25.0	30.4	-4.4	-5.5
Hypertension (Self-reported)	12.1	33.7	37.1	-5.5	-6.1
Heart disease (mother)	11.7	14.2	14.8	-3.9	-3.7
Primary Biliary Cirrhosis	10.7	15.2	17.2	-3.7	-4.1
Chronotype (morning person)	10.6	24.4	26.9	-5.2	-4.7
Qualifications: NVQ or HND or HNC or equivalent	10.5	12.6	15.3	3.9	3.1
Ever highly irritable/argumentative for 2 days	10.1	12.2	12.3	3.5	3.5
Fed-up feelings	10.0	18.2	21.7	3.8	4.7
Frequency of tiredness / lethargy in last 2 weeks	9.9	16.1	19.6	3.6	4.4
Past tobacco smoking	9.8	18.0	19.5	4.1	4.4
Medication: Blood pressure	9.5	16.7	18.1	-3.9	-4.3
Pain experienced in last month	9.5	15.9	17.2	-3.8	-4.1
Number of self-reported non-cancer illnesses	9.3	16.2	19.1	-3.7	-4.4
Birth weight	9.0	19.5	20.2	4.5	4.3
Medication: Allopurinol	8.6	11.4	14.1	-3.0	-3.8
Medication for cholesterol	8.5	12.9	17.4	2.9	4.2
Smoking status: Current	8.5	13.5	14.8	3.5	3.9
Taking other prescription medications	8.4	12.9	17.4	-2.9	-4.2
Headache pain in last month	8.3	14.3	18.4	3.2	4.3
Loneliness, isolation	7.8	10.8	10.9	3.3	3.3
Gout (self-reported)	7.7	10.5	14.0	-2.7	-3.7
Current tobacco smoking	7.4	12.0	13.1	3.3	3.6
Illnesses of father: None of the above (group 1)	7.4	9.1	10.1	2.9	3.2
Number of treatments/medications taken	7.1	12.8	15.8	-3.1	-4.0
Frequency of unenthusiasm / disinterest in last 2 weeks	7.1	9.5	11.0	3.3	2.8
Illnesses of siblings	6.8	9.5	9.7	3.1	3.1
Back pain experienced in last month	6.8	10.0	11.3	3.4	2.9
Ever smoked	6.8	11.9	12.4	-3.4	-3.5
Depression (Nagel 2018)	6.6	9.9	11.4	3.4	2.9
Father’s age at death	6.4	8.6	12.5	2.2	3.5
Medication: Bendroflumethiazide	6.4	9.7	9.8	-3.1	-3.1
Depressed Affect (Nagel 2018)	6.2	13.1	15.4	3.3	3.9
Number of full brothers	6.1	7.6	10.1	2.3	3.2
Diverticular disease/diverticulitis (self-reported)	6.0	7.1	9.1	2.3	3.0
Mood swings	6.0	10.8	11.3	3.2	3.4
Heart attack/myocardial infarction (self-reported)	5.7	7.4	7.9	-2.6	-2.8
Rheumatoid Arthritis	5.3	7.3	9.7	-2.2	-3.1
Hip circumference	5.2	22.3	25.0	4.4	5.0
Blood clot in the leg (DVT)	5.2	6.7	7.2	-2.5	-2.7
Medication: Ibuprofen (e.g. Nurofen)	5.1	6.5	7.3	2.4	2.7
Medication: Lansoprazole	5.1	5.8	7.3	-2.1	-2.7
High blood pressure (siblings)	5.1	7.4	7.5	-2.7	-2.7
Arm predicted mass (left)	4.9	24.9	34.0	4.0	5.8
Medication: Aspirin	4.8	6.4	7.7	-2.3	-2.8
Arm fat-free mass (left)	4.8	24.3	33.5	3.9	5.8
Heart attack	4.6	5.9	6.2	-2.4	-2.5
Frequency of tenseness / restlessness in last 2 weeks	4.5	7.1	7.1	2.7	2.7
Knee pain experienced in last month	4.5	7.0	7.8	2.5	2.8
Lupus	4.4	6.7	8.1	-2.3	-2.9
Trunk predicted mass	4.4	25.1	33.5	4.1	5.8
Illnesses of father: Heart disease	4.4	6.2	6.7	-2.6	-2.4
Medication: Ramipril	4.3	5.5	6.7	-2.6	-2.1
Trunk fat-free mass	4.3	24.7	33.0	4.1	5.7
Deep venous thrombosis (DVT) (self-reported)	4.3	5.5	6.0	-2.2	-2.5
Comparative height size at age 10	4.2	22.9	27.8	4.2	5.3
Medication: Omeprazole (e.g. Zanprol)	4.2	5.1	5.8	-2.1	-2.4
Medication: Ibuprofen	4.1	5.0	5.7	2.1	2.4
Pack years adult smoking proportion	3.9	5.9	6.0	2.5	2.4
Illnesses of mother	3.9	4.9	5.3	2.1	2.3
Arm fat-free mass (right)	3.9	20.0	27.7	3.5	5.3
Medication: Lisinopril	3.9	5.0	6.0	-2.0	-2.5
Arm predicted mass (right)	3.7	19.0	26.5	3.4	5.1
Basal metabolic rate	3.7	20.3	27.3	3.6	5.2
Frequency of depressed mood in last 2 weeks	3.6	5.0	6.0	2.4	2.0
Whole body water mass	3.6	20.5	27.9	3.6	5.3
HbA1C	3.5	3.8	5.7	2.4	1.4
Medication for cholesterol, blood pressure or diabetes	3.5	5.8	6.1	2.3	2.5
Migraine (self-reported)	3.5	4.4	4.5	2.1	2.1
Whole body fat-free mass	3.5	19.9	27.1	3.6	5.2
Suffer from ‘nerves’	3.4	5.3	7.3	2.7	1.8
Weight	3.2	15.7	19.7	3.4	4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.2	3.7	5.3	-1.4	-2.3
Illnesses of father: High blood pressure	3.2	3.9	4.0	-2.0	-2.0
Cholesterol lowering medication	3.1	4.6	4.7	-2.1	-2.2
Supplements: Calcium	3.1	3.4	4.0	-1.7	-2.0
Neuroticism score	3.0	6.2	7.3	2.7	2.3
Mouth/teeth dental problems: Bleeding gums	3.0	3.9	4.0	-2.0	-1.9
Pack years of smoking	3.0	4.4	4.4	2.1	2.1
Type 2 Diabetes (T2D) (2018)	2.9	5.5	6.3	-2.2	-2.5
Mouth/teeth dental problems: Loose teeth	2.9	3.5	4.2	2.0	1.7
Medication: Aspirin	2.9	3.8	4.8	-1.7	-2.2
Alcohol drinker status: Previous	2.9	3.3	4.5	-1.5	-2.1
Ulcerative Colitis (UC)	2.8	5.2	6.4	-2.0	-2.5
Alcohol intake versus 10 years previously	2.8	4.2	4.2	-2.1	-2.0
Diabetes diagnosed by doctor	2.8	4.6	6.7	-1.6	-2.6
Risk taking	2.8	4.2	4.2	2.1	2.0
High blood pressure (mother)	2.7	3.8	4.5	-2.1	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	3.2	-1.8	-1.8
Waist circumference	2.6	9.6	10.5	3.0	3.2
Fluid intelligence score	2.6	5.4	5.6	-2.4	-2.3
Mean Putamen Volume	2.4	2.7	2.7	1.6	1.6
Angina	2.4	3.1	3.6	-1.6	-1.9
Neck or shoulder pain in last month	2.4	3.4	4.0	1.7	2.0
Leg fat mass (right)	2.4	9.4	11.1	2.8	3.3
Verbal and Numeric Reasoning (VNR)	2.3	5.5	8.2	-2.9	-1.7
Leg fat-free mass (left)	2.3	12.3	16.3	2.9	4.0
Leg predicted mass (left)	2.3	11.9	15.8	2.8	4.0
Medication for pain relief, constipation, heartburn	2.3	3.9	4.0	2.0	2.0
High cholesterol (Self-reported)	2.3	4.0	4.7	-2.2	-1.9
Neuroticism (Nagel 2018)	2.2	5.3	5.7	2.4	2.2
Supplements: Zinc	2.2	2.4	2.8	1.4	1.7
Exposure to tobacco smoke outside home	2.2	2.9	5.3	-0.7	-2.3
Ever depressed for a whole week	2.2	2.7	3.6	1.3	1.9
Impedance of arm (left)	2.1	9.6	13.7	-2.3	-3.7
Age started oral contraceptive pill	2.1	2.7	3.1	-1.5	-1.8
Leg fat mass (left)	2.1	8.2	9.9	2.5	3.1
Relative age voice broke	2.0	3.0	5.2	-2.3	-0.9
Whole body fat mass	2.0	8.3	9.8	2.6	3.1
Irritable Bowel Disease (IBD)	1.9	4.5	6.8	-1.5	-2.6
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	4.3	1.3	2.1
Pulse rate	1.8	3.0	3.2	-1.7	-1.8
Medication: Amlodipine	1.8	2.6	3.5	-1.3	-1.9
Angina (self-reported)	1.8	2.3	2.8	-1.3	-1.7
Fractured/broken bones in last 5 years	1.8	2.4	3.2	-1.8	-1.2
Intelligence (Savage-Jansen 2018)	1.7	5.2	7.6	-2.8	-1.7
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	2.4	1.5	1.1
Arm fat mass (right)	1.7	6.9	8.3	2.4	2.9
Leg pain on walking	1.7	2.1	2.9	1.2	1.7
Leg fat-free mass (right)	1.7	9.3	13.2	2.3	3.6
Leg predicted mass (right)	1.7	8.9	12.7	2.2	3.6
Miserableness	1.7	3.0	3.9	1.4	2.0
Average weekly beer plus cider intake	1.7	2.5	3.8	1.9	1.1
Lung FVC	1.6	8.1	11.8	-2.1	-3.4
Neuroticism	1.6	3.8	4.3	2.1	1.8
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	2.1	-1.4	-1.4
Multivitamins +/- minerals	1.6	2.0	2.5	1.3	1.6
Trunk fat mass	1.6	7.0	7.9	2.5	2.8
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	2.6	1.2	1.6
Leg fat percentage (right)	1.6	5.6	5.8	2.3	2.4
Worry (Nagel 2018)	1.5	3.2	4.2	2.1	1.5
Allergy or Eczema	1.5	3.9	5.2	1.6	2.3
Relative age of first facial hair	1.5	3.1	4.5	-2.1	-1.3
Standing height	1.5	15.1	20.9	3.1	4.6
Ever taken oral contraceptive pill	1.5	1.7	2.8	0.8	1.7
Height	1.3	24.8	34.7	3.9	5.9
Tanning	1.3	15.6	16.2	-3.9	-4.0
Body mass index (BMI)	1.3	5.6	6.4	2.2	2.5
Falls in the last year	1.3	1.8	2.1	1.2	1.4
Comparative body size at age 10	1.3	3.6	3.7	-1.9	-1.9
Arm fat mass (left)	1.3	5.2	6.2	2.1	2.5
Sensitivity / hurt feelings	1.2	2.0	2.1	-1.4	-1.4
Vitamin and mineral supplements	1.2	1.7	1.7	-1.3	-1.3
Diabetes (father)	1.2	1.5	1.9	-1.4	-1.0
Hayfever, allergic rhinitis or eczema	1.2	2.6	3.2	1.5	1.8
Number of children fathered	1.2	1.4	2.1	0.8	1.5
Medication: Omeprazole	1.2	1.5	1.6	-1.2	-1.3
Mother’s age at death	1.2	1.5	2.2	0.8	1.5
Type 2 Diabetes (T2D) (2012)	1.1	1.3	1.9	-1.4	-0.8
Lung FEV1/FVC ratio	1.1	5.7	7.5	2.0	2.7
Stomach or abdominal pain in last month	1.1	1.4	2.0	0.9	1.4
Diabetes (self-reported)	1.1	1.7	2.2	-1.1	-1.5
Leg fat percentage (left)	1.1	3.9	4.5	1.9	2.1
Waist Hip Ratio (WHR)	1.0	4.5	4.5	-2.1	-2.1
Hair Pigment	1.0	28.1	35.0	4.6	5.9
Worrier / anxious feelings	1.0	1.9	2.1	1.5	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.0	-1.4	-0.6
Eye problems/disorders: Cataract	1.0	1.1	1.7	0.7	1.3
Guilty feelings	1.0	1.5	2.5	1.6	0.7
Tinnitus: Yes, now most or all of the time	1.0	1.1	2.2	0.0	-1.5
Body Mass Index (BMI) (2010)	0.9	1.2	2.4	0.1	1.5
BMI	0.9	5.2	5.8	2.2	2.4
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	2.0	1.4	1.4
Mouth/teeth dental problems	0.9	1.3	1.5	-1.2	-1.1
Medication: Simvastatin	0.9	1.3	1.8	-0.9	-1.4
Pulse wave Arterial Stiffness index	0.9	1.0	1.3	-1.1	-0.8
Chronic bronchitis/emphysema (mother)	0.9	1.1	1.7	-0.6	-1.3
Osteoporosis (self-reported)	0.9	1.2	1.5	-1.2	-0.9
Impedance of whole body	0.9	4.4	6.1	-1.6	-2.5
Blood Platelet Count	0.8	9.5	13.1	2.4	-3.6
Smoking Status	0.8	1.9	2.1	-1.4	-1.3
Medication for hormone replacement therapy	0.8	0.9	1.5	1.2	0.5
Medication: Metformin	0.8	1.1	2.1	1.5	0.1
Impedance of arm (right)	0.8	3.6	5.9	-1.2	-2.4
Medication: Cholesterol lowering	0.8	1.3	1.4	-1.2	-1.1
Pulse wave peak to peak time	0.8	0.9	1.2	1.1	0.8
Alcohol intake frequency.	0.8	1.8	2.2	-1.5	-1.1
Had major operations	0.8	1.0	1.4	-1.2	-0.7
Long-standing illness, disability or infirmity	0.8	1.2	2.4	-0.1	-1.6
Medication: Gliclazide	0.8	0.9	1.0	-0.8	-1.0
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.0	1.0	1.0
Schizophrenia vs Biploar Disorder	0.7	1.0	1.6	-1.3	-0.5
Crohns Disease (2017)	0.7	1.5	2.9	-0.3	-1.7
Ovarian Cancer	0.7	0.9	1.5	-0.5	-1.2
Chronic bronchitis/emphysema (father)	0.7	0.8	1.1	0.7	1.1
Health satisfaction	0.7	0.9	1.4	1.2	0.7
Medication: Seretide 50 evohaler	0.7	0.8	0.9	-1.0	-0.8
Illnesses of siblings: Diabetes	0.7	0.9	1.4	-1.2	-0.5
Commuting to job workplace: Public transport	0.7	0.9	1.1	-0.8	-1.0
Hearing difficulty/problems: Yes	0.6	1.0	1.5	-0.6	-1.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.1	-1.1	-0.6
Arm fat percentage (right)	0.6	2.3	2.6	1.6	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.0	0.9	1.0
Body fat percentage	0.6	2.5	2.5	1.6	1.6
Pulse rate, automated reading	0.6	1.9	3.2	-0.8	-1.8
Number of full sisters	0.6	0.8	1.3	0.5	1.1
Average weekly red wine intake	0.6	0.8	1.1	0.8	1.1
Breast cancer (self-reported)	0.6	0.7	1.3	0.3	1.1
Average weekly champagne plus white wine intake	0.6	0.9	1.1	-1.0	-0.8
Bipolar Disorder (2011)	0.5	0.5	0.7	0.8	0.5
Ulcerative Colitis	0.5	0.7	1.1	-0.6	-1.0
Medication: Co-codamol	0.5	0.6	0.7	0.7	0.9
Age when periods started (menarche)	0.5	1.1	1.2	-1.1	-1.0
Serious illness, injury or assault to yourself	0.5	0.6	0.7	-0.7	-0.9
Number of incorrect matches in round	0.5	0.9	1.7	0.2	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	1.4	1.0	1.2
Qualifications: None of the above	0.5	1.1	2.1	-0.3	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.1	-1.1	0.3
Pulse wave reflection index	0.5	0.6	0.8	-0.7	-0.9
Alcohol drinker status: Never	0.5	0.6	0.9	0.6	0.9
Major Depression (MDD)	0.4	0.5	0.8	0.4	0.9
Crohns Disease (2012)	0.4	0.6	1.2	-0.1	-1.1
Trunk fat percentage	0.4	1.8	1.8	1.3	1.3
Hearing difficulty/problems with background noise	0.4	0.7	1.0	1.0	0.7
Allergy	0.4	1.0	1.5	-0.7	-1.2
Exposure to tobacco smoke at home	0.4	0.5	0.5	-0.7	-0.7
Peak expiratory flow (PEF)	0.4	1.0	1.0	-1.0	-1.0
Heart disease (siblings)	0.4	0.5	0.8	-0.4	-0.9
Schizophrenia (2018)	0.3	0.6	0.8	0.6	0.9
Alzheimer’s Disease (in mother)	0.3	0.4	0.5	-0.5	-0.7
Fasting Glucose	0.3	0.4	0.7	0.1	0.9
Schizophrenia (2014)	0.3	0.7	1.1	1.1	0.6
Respiratory disease	0.3	0.7	0.8	-0.9	-0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.6	0.8	0.2
Townsend deprivation index at recruitment	0.3	0.4	0.5	-0.5	-0.7
Alcohol usually taken with meals	0.3	0.5	1.0	-1.0	0.1
Had other major operations	0.3	0.4	0.7	-0.8	0.2
Financial difficulties in last 2 years	0.3	0.4	0.5	0.7	0.5
Happiness	0.3	0.3	0.6	0.3	0.8
Depression (self-reported)	0.3	0.4	0.7	0.2	0.8
Lung cancer (father)	0.3	0.4	0.6	0.7	0.4
Hair/balding pattern: Pattern 4	0.3	0.8	1.4	-0.5	-1.2
Overall health rating	0.3	0.6	0.6	0.8	0.7
Age at last live birth	0.3	0.4	0.8	-0.9	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	0.7	0.8	0.8
Arm fat percentage (left)	0.3	1.4	1.7	1.3	1.0
Qualifications: nursing, teaching	0.3	0.5	1.0	0.1	1.0
Hearing aid user	0.3	0.3	0.5	-0.3	-0.7
Number of operations (self-reported)	0.3	0.4	0.5	-0.5	0.7
Irritability	0.3	0.5	0.6	0.8	0.6
Bipolar Disorder (2018)	0.2	0.4	0.5	0.5	-0.7
HDL Cholesterol	0.2	0.3	0.5	-0.4	0.7
Heel T-Score	0.2	1.2	1.4	-1.0	-1.2
Average weekly spirits intake	0.2	0.3	0.4	-0.6	-0.4
Qualifications: CSEs or equivalent	0.2	0.3	0.3	-0.4	0.6
Nervous feelings	0.2	0.4	0.8	0.9	0.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.4	0.7	0.3
Time employed in main current job	0.2	0.2	0.4	0.3	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.0	-0.2	1.0
Prospective memory result	0.2	0.2	0.5	0.7	-0.0
Glaucoma (self-reported)	0.2	0.2	0.3	0.3	0.5
Shortness of breath walking on level ground	0.2	0.3	0.5	0.7	0.1
Chest pain or discomfort	0.2	0.3	0.3	0.6	0.4
Ever had bowel cancer screening	0.2	0.2	0.3	-0.5	-0.4
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.1	0.7
Wears glasses or contact lenses	0.2	0.2	0.2	-0.5	-0.4
Financial situation satisfaction	0.2	0.2	0.4	0.7	0.1
Medication: Paracetamol	0.2	0.3	0.3	0.5	0.5
Unable to work because of sickness or disability	0.2	0.2	0.4	-0.1	-0.6
Myopia	0.2	0.3	0.4	-0.3	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.4	0.7	0.8	0.2
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	0.1	-0.6
Ever had hysterectomy (womb removed)	0.1	0.2	0.3	0.5	0.1
Severe depression (siblings)	0.1	0.1	0.2	-0.1	0.5
Hand grip strength (right)	0.1	0.4	0.7	-0.9	-0.3
Supplements: Glucosamine	0.1	0.1	0.1	0.1	0.4
Impedance of leg (left)	0.1	0.3	0.4	-0.5	-0.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	0.0	0.5
Had menopause	0.1	0.2	0.2	0.5	-0.3
Forced vital capacity (FVC)	0.1	0.3	0.6	-0.2	-0.8
Pain all over the body in last month	0.1	0.1	0.2	-0.3	-0.4
Number of live births	0.1	0.2	0.2	0.4	0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.5	-0.5	-0.7
Noisy workplace	0.1	0.2	0.3	0.2	0.5
Mouth/teeth dental problems: Dentures	0.1	0.1	0.1	0.4	0.3
Breastfed as a baby	0.1	0.2	0.2	-0.5	0.3
Tense / ‘highly strung’	0.1	0.1	0.2	0.5	0.1
Loud music exposure frequency	0.1	0.1	0.2	0.5	-0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.3	0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.4	0.4
Forced vital capacity (FVC), Best measure	0.1	0.4	0.7	-0.3	-0.8
Worry too long after embarrassment	0.1	0.3	0.5	0.7	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.2	-0.3	-0.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.6	-0.2
Age at first live birth	0.1	0.2	0.3	-0.5	-0.2
Qualifications: College or University degree	0.1	0.2	0.3	-0.5	-0.2
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.4	-0.4
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.3	0.3
Family relationship satisfaction	0.1	0.1	0.2	-0.0	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.1	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	0.6	0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.5	0.3
Friendships satisfaction	0.1	0.1	0.1	-0.4	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.4	-0.1
Osteoarthritis (self-reported)	0.1	0.2	0.3	-0.6	-0.1
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.2	-0.3	0.5
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.2	-0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.0	0.1	0.1	0.0	0.3
Neuroticism (2016)	0.0	0.0	0.0	0.2	0.0
Triglycerides	0.0	0.0	0.1	-0.2	0.1
Hand grip strength (left)	0.0	0.1	0.2	-0.4	0.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	0.3	-0.1
Diabetes (mother)	0.0	0.0	0.0	-0.1	0.2
Impedance of leg (right)	0.0	0.0	0.0	0.2	-0.2
Average weekly fortified wine intake	0.0	0.1	0.1	-0.2	0.3
Maternal smoking around birth	0.0	0.1	0.1	0.2	0.3
Sitting height	0.0	0.1	0.2	-0.5	0.0
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	-0.3	0.1
Asthma	0.0	0.0	0.1	0.0	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.1	-0.1	-0.3
Length of working week for main job	0.0	0.0	0.0	-0.2	0.1
Medication: Paracetamol	0.0	0.0	0.1	-0.0	0.3
Supplements: Vitamin C	0.0	0.0	0.0	-0.1	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	0.2	-0.1
Mineral and other dietary supplements	0.0	0.0	0.1	0.1	0.2
Asthma (self-reported)	0.0	0.0	0.0	-0.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	-0.1	-0.4
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	0.1	-0.2
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	0.0	-0.1
Medication: Atorvastatin	0.0	0.0	0.0	0.0	0.1
Commuting to job workplace: Cycle	0.0	0.0	0.1	0.1	0.3
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	0.1	-0.1

Hub : Genes

BRAP

Models

Trait associations