Best TWAS P=1.16e-08 · Best GWAS P=5.49e-08 conditioned to 0.17
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | TRIM37 | 0.18 | 0.22 | enet | 25 | 0.24 | 6.9e-20 | 5.0 | -5.2 | 1.7e-07 | -0.87 | 0.04 | 0.96 | FALSE |
2 | GTEx | Colon Transverse | TRIM37 | 0.14 | 0.15 | lasso | 6 | 0.17 | 1.5e-08 | 5.1 | -5.2 | 1.9e-07 | -0.83 | 0.07 | 0.92 | FALSE |
3 | GTEx | Esophagus Gastroesophageal Junction | TRIM37 | 0.15 | 0.06 | lasso | 5 | 0.10 | 2.4e-04 | 5.4 | -5.2 | 2.0e-07 | -0.89 | 0.04 | 0.94 | FALSE |
4 | GTEx | Esophagus Muscularis | TRIM37 | 0.11 | 0.05 | lasso | 5 | 0.09 | 2.7e-06 | 5.1 | -5.2 | 1.6e-07 | -0.82 | 0.12 | 0.87 | FALSE |
5 | GTEx | Esophagus Muscularis | AC099850.1 | 0.06 | 0.00 | enet | 22 | 0.00 | 1.7e-01 | 5.2 | -5.5 | 4.1e-08 | -0.83 | 0.06 | 0.65 | FALSE |
6 | GTEx | Lung | TRIM37 | 0.05 | 0.04 | enet | 7 | 0.05 | 5.3e-05 | 5.1 | -5.2 | 1.9e-07 | -0.87 | 0.05 | 0.94 | FALSE |
7 | GTEx | Nerve Tibial | SMG8 | 0.08 | 0.06 | lasso | 7 | 0.05 | 1.0e-04 | 5.1 | -5.1 | 2.9e-07 | -0.94 | 0.02 | 0.96 | FALSE |
8 | GTEx | Pancreas | TRIM37 | 0.08 | 0.05 | lasso | 7 | 0.02 | 3.2e-02 | 4.9 | -5.2 | 1.8e-07 | -0.89 | 0.05 | 0.83 | FALSE |
9 | GTEx | Spleen | TRIM37 | 0.13 | 0.08 | enet | 16 | 0.18 | 2.8e-05 | 5.1 | -5.7 | 1.2e-08 | -0.81 | 0.05 | 0.83 | TRUE |
10 | GTEx | Thyroid | TRIM37 | 0.04 | 0.04 | enet | 7 | 0.06 | 2.4e-05 | 5.2 | -5.2 | 1.8e-07 | -0.77 | 0.06 | 0.91 | FALSE |