Best TWAS P=1.7e-09 · Best GWAS P=4.11e-07 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TCTA | 0.05 | 0.01 | enet | 10 | 0.01 | 5.8e-02 | 4.3 | -5.2 | 2.1e-07 | 0.07 | 0.06 | 0.39 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | RBM6 | 0.20 | 0.14 | enet | 16 | 0.11 | 5.5e-04 | -4.3 | -5.5 | 3.8e-08 | -0.29 | 0.36 | 0.36 | FALSE |
| 3 | GTEx | Brain Cerebellum | GPX1 | 0.31 | 0.09 | enet | 19 | 0.23 | 2.0e-07 | -4.2 | 5.5 | 4.5e-08 | -0.04 | 0.10 | 0.74 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | GPX1 | 0.16 | 0.06 | lasso | 6 | 0.15 | 7.9e-05 | 4.1 | 6.0 | 1.7e-09 | -0.01 | 0.05 | 0.61 | TRUE |
| 5 | GTEx | Esophagus Muscularis | GPX1 | 0.13 | 0.05 | lasso | 14 | 0.06 | 1.1e-04 | -4.2 | 5.5 | 3.3e-08 | -0.04 | 0.10 | 0.75 | FALSE |
| 6 | GTEx | Lung | GPX1 | 0.04 | 0.02 | enet | 13 | 0.04 | 5.7e-04 | -4.0 | 5.6 | 1.6e-08 | 0.00 | 0.06 | 0.39 | FALSE |
| 7 | GTEx | Nerve Tibial | HYAL1 | 0.08 | 0.06 | enet | 14 | 0.05 | 3.6e-04 | 3.6 | 5.2 | 2.5e-07 | 0.60 | 0.06 | 0.78 | FALSE |
| 8 | GTEx | Nerve Tibial | U73166.2 | 0.07 | 0.03 | lasso | 3 | 0.03 | 2.8e-03 | 5.0 | -5.1 | 2.9e-07 | -0.96 | 0.01 | 0.97 | TRUE |