TWAS
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Neuroticism
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chr3:51,860,817-53,489,090
Best TWAS P=6.95e-08 · Best GWAS P=6.56e-08 conditioned to 1
51.8M
52M
52.2M
52.4M
52.6M
52.8M
53M
53.2M
53.4M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Skin Sun Exposed Lower leg
NT5DC2
0.21
0.19
enet
12
0.18
2.0e-14
-5.4
5.4
6.9e-08
-0.99
0.02
0.98
TRUE
2
GTEx
Skin Not Sun Exposed Suprapubic
NT5DC2
0.23
0.10
lasso
4
0.09
8.3e-06
-5.4
5.4
8.0e-08
-1.00
0.02
0.98
FALSE
4
The Cancer Genome Atlas
Thyroid Carcinoma
NEK4
0.07
0.12
blup
69
0.12
6.3e-12
-5.1
5.1
2.7e-07
-0.90
0.03
0.96
FALSE
1
GTEx
Adipose Visceral Omentum
NEK4
0.10
0.09
lasso
3
0.08
5.0e-05
-5.1
5.1
3.0e-07
-0.87
0.09
0.90
FALSE