[Hub]/) : Traits : Neuroticism :

chr3:135,273,949-137,423,165

Best TWAS P=1.38e-12 · Best GWAS P=2.98e-12 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PCCB 0.09 0.19 lasso 7 0.18 1.2e-21 -7.0 -6.9 5.2e-12 0.98 0.02 0.98 FALSE
2 GTEx Adipose Subcutaneous PCCB 0.07 0.05 enet 4 0.02 6.6e-03 5.6 -5.7 1.5e-08 0.75 0.07 0.84 FALSE
3 GTEx Adrenal Gland PCCB 0.17 0.09 lasso 6 0.10 2.1e-04 -6.9 -5.8 7.3e-09 0.94 0.03 0.93 FALSE
4 GTEx Artery Coronary RP11-85F14.5 0.15 0.01 lasso 4 0.00 2.3e-01 -6.9 -6.8 7.5e-12 0.91 0.03 0.81 FALSE
5 GTEx Artery Tibial PCCB 0.05 0.02 lasso 5 0.02 1.7e-02 -6.4 -5.8 5.1e-09 0.91 0.04 0.95 FALSE
6 GTEx Brain Caudate basal ganglia PCCB 0.11 0.01 enet 12 0.01 2.1e-01 -6.6 -6.6 3.9e-11 0.79 0.04 0.51 FALSE
7 GTEx Brain Frontal Cortex BA9 PCCB 0.11 0.01 enet 9 0.01 1.7e-01 5.6 -5.7 9.8e-09 0.82 0.05 0.60 FALSE
8 GTEx Breast Mammary Tissue PCCB 0.08 0.05 lasso 3 0.03 1.3e-02 5.6 -6.0 1.9e-09 0.79 0.07 0.76 FALSE
9 GTEx Cells EBV-transformed lymphocytes PCCB 0.11 0.10 lasso 3 0.11 2.3e-04 -3.5 -5.4 6.7e-08 0.73 0.04 0.87 FALSE
10 GTEx Cells Transformed fibroblasts PCCB 0.10 0.09 lasso 3 0.07 5.0e-06 -6.7 -6.5 6.0e-11 0.95 0.04 0.96 FALSE
11 GTEx Colon Transverse PCCB 0.07 0.06 lasso 3 0.04 7.7e-03 -6.7 -6.3 2.2e-10 0.92 0.04 0.91 FALSE
12 GTEx Esophagus Mucosa PCCB 0.10 0.12 lasso 3 0.11 4.8e-08 -6.9 -6.8 1.1e-11 0.95 0.02 0.98 FALSE
13 GTEx Heart Left Ventricle PCCB 0.08 0.05 enet 7 0.01 7.2e-02 -6.4 -6.6 4.7e-11 0.91 0.03 0.96 FALSE
14 GTEx Lung PCCB 0.07 0.04 lasso 3 0.03 4.2e-03 -6.7 -6.8 7.9e-12 0.91 0.04 0.90 FALSE
15 GTEx Muscle Skeletal PCCB 0.09 0.09 enet 13 0.11 1.2e-10 -6.9 -6.6 5.0e-11 0.91 0.02 0.98 FALSE
16 GTEx Skin Not Sun Exposed Suprapubic IL20RB 0.22 0.16 lasso 9 0.19 1.2e-10 5.5 5.3 9.0e-08 -0.55 1.00 0.00 FALSE
17 GTEx Testis PCCB 0.26 0.22 lasso 10 0.22 4.7e-10 -6.9 -6.8 1.3e-11 0.96 0.02 0.98 FALSE
18 GTEx Thyroid PCCB 0.10 0.09 lasso 6 0.09 1.3e-07 -6.5 -6.0 2.2e-09 0.86 0.07 0.93 FALSE
19 METSIM Adipose PCCB 0.07 0.06 lasso 12 0.06 4.1e-09 -6.9 -6.2 5.9e-10 0.93 0.02 0.98 FALSE
20 ROSMAP Brain Pre-frontal Cortex PCCB 0.10 0.07 lasso 4 0.10 4.2e-13 -6.9 -5.8 7.0e-09 0.85 0.03 0.97 FALSE
21 YFS Blood PCCB 0.13 0.20 lasso 9 0.20 1.3e-64 -6.9 -6.9 6.0e-12 0.97 0.02 0.98 FALSE
22 The Cancer Genome Atlas Bladder Urothelial Carcinoma PCCB 0.05 0.03 blup 53 0.03 1.2e-03 -6.9 -6.3 2.4e-10 0.93 0.01 0.94 FALSE
23 The Cancer Genome Atlas Breast Invasive Carcinoma PCCB 0.05 0.02 enet 12 0.04 4.0e-09 -7.0 -5.8 8.0e-09 0.84 0.00 1.00 FALSE
24 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma PCCB 0.13 0.01 enet 5 0.04 6.4e-03 -2.0 -5.3 1.0e-07 0.69 0.02 0.47 FALSE
25 The Cancer Genome Atlas Colon Adenocarcinoma PCCB 0.11 0.03 blup 54 0.04 2.3e-03 -6.9 -7.1 1.4e-12 0.96 0.01 0.77 FALSE
26 The Cancer Genome Atlas Esophageal Carcinoma PCCB 0.15 0.03 blup 54 0.05 9.6e-03 -6.4 -6.9 4.6e-12 0.92 0.01 0.70 FALSE
27 The Cancer Genome Atlas Glioblastoma Multiforme PCCB 0.10 0.03 blup 53 0.02 5.8e-02 -6.4 -7.0 3.1e-12 0.95 0.01 0.73 FALSE
28 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MSL2 0.07 0.02 enet 6 0.03 1.7e-04 -6.5 -6.2 6.5e-10 0.85 0.00 0.97 FALSE
29 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PCCB 0.12 0.05 enet 7 0.09 9.7e-11 -6.4 -6.8 9.0e-12 0.86 0.01 0.99 FALSE
30 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma STAG1 0.04 0.02 lasso 3 0.02 4.1e-03 5.8 -6.8 1.2e-11 0.79 0.04 0.88 FALSE
31 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PCCB 0.05 0.05 blup 54 0.05 3.5e-06 -6.9 -6.7 2.7e-11 0.90 0.01 0.99 FALSE
32 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PPP2R3A 0.05 0.02 enet 8 0.02 1.1e-03 -6.5 -5.3 9.6e-08 0.79 0.00 0.95 FALSE
33 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PCCB 0.07 0.06 blup 53 0.06 2.1e-04 -6.6 -6.1 1.2e-09 0.91 0.01 0.97 FALSE
34 The Cancer Genome Atlas Brain Lower Grade Glioma PCCB 0.06 0.05 lasso 2 0.03 1.2e-04 -6.9 -6.7 2.4e-11 0.94 0.01 0.99 FALSE
35 The Cancer Genome Atlas Lung Adenocarcinoma PCCB 0.11 0.10 lasso 3 0.10 1.3e-11 -6.9 -6.8 9.1e-12 0.97 0.01 0.99 FALSE
36 The Cancer Genome Atlas Lung Adenocarcinoma STAG1 0.02 0.02 enet 6 0.02 3.5e-03 -6.9 -6.9 4.0e-12 0.95 0.02 0.87 FALSE
37 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MSL2 0.04 0.02 blup 35 0.01 1.9e-02 -6.4 -6.4 1.2e-10 0.86 0.00 0.94 FALSE
38 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PCCB 0.13 0.10 lasso 4 0.10 2.4e-11 -6.4 -6.5 1.0e-10 0.93 0.01 0.99 FALSE
39 The Cancer Genome Atlas Lung Squamous Cell Carcinoma STAG1 0.05 0.00 blup 151 0.01 2.9e-02 -7.0 -7.1 1.4e-12 0.96 0.02 0.97 TRUE
40 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MSL2 0.09 0.01 blup 35 0.02 8.1e-03 5.6 -6.5 1.0e-10 0.86 0.00 0.90 FALSE
41 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma PCCB 0.12 0.07 enet 3 0.06 1.0e-04 -6.4 -6.5 9.6e-11 0.92 0.01 0.97 FALSE
42 The Cancer Genome Atlas Pancreatic Adenocarcinoma PCCB 0.12 0.02 lasso 5 0.02 6.7e-02 -6.9 -6.4 2.1e-10 0.91 0.01 0.82 FALSE
43 The Cancer Genome Atlas Prostate Adenocarcinoma PCCB 0.06 0.02 lasso 2 0.03 2.3e-04 4.6 -6.1 1.1e-09 0.84 0.02 0.96 FALSE
44 The Cancer Genome Atlas Soft Tissue Sarcoma PCCB 0.14 0.10 enet 6 0.10 1.0e-06 -6.9 -7.0 2.7e-12 0.95 0.00 1.00 FALSE
45 The Cancer Genome Atlas Soft Tissue Sarcoma STAG1 0.06 0.06 lasso 1 0.04 2.0e-03 -7.0 -7.0 3.0e-12 1.00 0.02 0.83 FALSE
46 The Cancer Genome Atlas Stomach Adenocarcinoma PCCB 0.07 0.04 lasso 1 0.02 1.1e-02 -6.9 -6.9 5.4e-12 0.96 0.00 0.97 FALSE
47 The Cancer Genome Atlas Thyroid Carcinoma PCCB 0.06 0.03 enet 8 0.03 2.3e-04 -6.9 -6.6 3.4e-11 0.94 0.01 0.99 FALSE