[Hub]/) : Traits : Neuroticism : ← →

chr9:126,771,321-128,824,378

Best TWAS P=1.19e-08 · Best GWAS P=2.82e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Breast Mammary Tissue (Female)	PPP6C	0.14	0.04	lasso	4	0.04	3.1e-02	-5.6	5.7	1.2e-08	-0.97	0.04	0.89	TRUE
16	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NEK6	0.14	0.02	blup	87	0.05	2.8e-03	-4.1	5.2	2.0e-07	-0.12	0.00	0.29	TRUE
10	GTEx	Nerve Tibial	GAPVD1	0.17	0.08	lasso	10	0.10	9.3e-08	-5.5	5.6	2.2e-08	-0.87	0.04	0.96	FALSE
5	GTEx	Cells Transformed fibroblasts	PRPS1P2	0.09	0.11	enet	8	0.13	9.6e-10	-5.3	-5.5	3.2e-08	0.97	0.04	0.96	FALSE
1	GTEx	Artery Tibial	PRPS1P2	0.06	0.06	enet	6	0.05	9.2e-05	-5.5	-5.5	3.6e-08	1.00	0.03	0.97	FALSE
11	GTEx	Pancreas	PRPS1P2	0.16	0.13	lasso	6	0.12	8.7e-06	-5.5	-5.5	4.2e-08	0.99	0.03	0.97	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	GOLGA1	0.13	0.00	enet	8	0.06	3.8e-03	-5.3	-5.5	4.5e-08	0.88	0.04	0.89	FALSE
15	The Cancer Genome Atlas	Lung Adenocarcinoma	PPP6C	0.02	0.02	lasso	4	0.02	7.6e-04	-5.5	5.5	4.6e-08	-0.99	0.02	0.96	FALSE
2	GTEx	Breast Mammary Tissue (Male)	PPP6C	0.12	0.03	enet	12	0.03	6.5e-02	-5.5	5.4	5.7e-08	-0.99	0.03	0.62	FALSE
7	GTEx	Esophagus Mucosa	PPP6C	0.07	0.07	enet	21	0.08	7.1e-06	-5.5	5.4	5.9e-08	-0.87	0.03	0.97	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	PPP6C	0.08	0.13	enet	9	0.13	5.5e-13	-5.4	5.4	5.9e-08	-0.96	0.03	0.97	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPP6C	0.07	0.08	lasso	3	0.09	5.4e-10	-5.5	5.4	6.2e-08	-0.99	0.02	0.98	FALSE
8	GTEx	Esophagus Mucosa	PRPS1P2	0.07	0.08	lasso	3	0.07	1.5e-05	-5.5	-5.3	1.2e-07	0.99	0.03	0.97	FALSE
6	GTEx	Colon Transverse	PRPS1P2	0.11	0.10	lasso	1	0.08	1.8e-04	-5.3	-5.3	1.4e-07	0.95	0.03	0.95	FALSE
12	GTEx	Thyroid	PRPS1P2	0.08	0.09	enet	18	0.07	4.0e-06	-5.5	-5.3	1.5e-07	0.97	0.03	0.97	FALSE
9	GTEx	Muscle Skeletal	PPP6C	0.03	0.03	enet	6	0.01	3.0e-02	-5.2	5.2	2.1e-07	-0.97	0.04	0.93	FALSE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPP6C	0.06	0.08	lasso	7	0.07	1.8e-07	-5.4	5.2	2.3e-07	-0.94	0.03	0.97	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPP6C	0.02	0.02	lasso	2	0.01	1.5e-02	-5.3	5.2	2.6e-07	-0.95	0.02	0.64	FALSE