Best TWAS P=1.17e-08 · Best GWAS P=6.67e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | ROSMAP | Brain Pre-frontal Cortex | CNNM2 | 0.11 | 0.08 | lasso | 3 | 0.07 | 2.2e-09 | -5.7 | -5.7 | 1.2e-08 | 1.00 | 0.02 | 0.98 | TRUE |
| 1 | GTEx | Breast Mammary Tissue (Female) | CYP17A1-AS1 | 0.14 | 0.01 | lasso | 11 | 0.00 | 4.7e-01 | -5.5 | -5.7 | 1.4e-08 | 0.88 | 0.04 | 0.50 | FALSE |
| 3 | GTEx | Testis | CYP17A1-AS1 | 0.14 | 0.08 | enet | 5 | 0.10 | 2.3e-05 | -5.6 | 5.6 | 2.5e-08 | -0.98 | 0.03 | 0.96 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | CYP17A1-AS1 | 0.23 | 0.08 | enet | 23 | 0.13 | 1.9e-05 | -3.9 | -5.2 | 2.2e-07 | 0.63 | 0.15 | 0.40 | FALSE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | AS3MT | 0.06 | 0.09 | enet | 6 | 0.07 | 1.3e-06 | -4.1 | 5.2 | 2.4e-07 | -0.69 | 0.28 | 0.70 | FALSE |
| 5 | YFS | Blood | NT5C2 | 0.13 | 0.10 | bslmm | 382 | 0.11 | 7.3e-35 | -5.6 | -5.1 | 3.1e-07 | 0.94 | 0.02 | 0.98 | FALSE |