TWAS hub - NT5C2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0670	0.0240	1.2e-05	0.036	0.032	0.028	0.031	0.037	2.6e-05	8.0e-05	1.9e-04	9.8e-05	2.2e-05
2	GTEx	Adipose Subcutaneous	0.0880	0.0400	2.4e-03	0.052	NA	0.023	NA	0.035	4.4e-05	NA	5.5e-03	NA	6.5e-04
3	GTEx	Adipose Visceral Omentum	0.1290	0.0460	5.7e-05	0.072	NA	0.082	NA	0.063	1.4e-04	NA	5.0e-05	NA	3.5e-04
4	GTEx	Artery Aorta	0.0760	0.0350	1.2e-03	0.016	NA	-0.003	NA	0.007	4.1e-02	NA	5.5e-01	NA	1.2e-01
5	GTEx	Artery Tibial	0.0611	0.0311	1.8e-03	0.040	NA	0.004	NA	0.017	4.4e-04	NA	1.4e-01	NA	1.5e-02
6	GTEx	Brain Cerebellar Hemisphere	0.1480	0.0730	3.9e-03	0.103	NA	0.065	NA	0.057	1.4e-03	NA	9.2e-03	NA	1.4e-02
7	GTEx	Brain Cerebellum	0.2340	0.1080	4.5e-04	0.154	NA	0.001	NA	0.088	2.6e-05	NA	3.0e-01	NA	1.4e-03
8	GTEx	Brain Cortex	0.1960	0.0870	8.2e-03	0.036	NA	0.050	NA	0.000	3.7e-02	NA	1.7e-02	NA	3.3e-01
9	GTEx	Pituitary	0.1890	0.0860	9.3e-03	-0.012	NA	-0.003	NA	0.010	9.9e-01	NA	4.0e-01	NA	1.8e-01
10	GTEx	Testis	0.2020	0.0630	1.2e-04	0.030	NA	0.073	NA	0.077	1.7e-02	NA	3.8e-04	NA	2.8e-04
11	YFS	Blood	0.1327	0.0300	0.0e+00	0.098	0.112	0.111	0.113	0.108	2.0e-30	1.5e-34	1.9e-34	7.3e-35	2.3e-33
12	TCGA	Prostate Adenocarcinoma	0.1445	0.0602	2.7e-13	0.129	0.113	0.115	NA	0.116	2.0e-13	8.0e-12	4.5e-12	NA	4.4e-12

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Smoking Status	18.9	45.2	85.2	-0.0	8.8	9.0	-7.1	-8.8	-9.2	-8.2	-4.9	-3.7	-0.4	0.9	-8.1
Past tobacco smoking	15.3	28.1	52.3	1.2	-7.1	-7.2	5.1	6.4	7.2	5.9	5.1	3.9	1.5	-0.1	6.1
Ever smoked	11.8	20.8	40.4	-0.8	6.0	5.8	-4.5	-6.1	-6.4	-5.4	-4.2	-2.6	-1.0	0.6	-5.2
Smoking status: Current	9.6	15.2	31.0	-0.6	5.4	5.6	-4.1	-5.2	-5.4	-4.4	-3.1	-1.5	-0.3	1.3	-3.9
Systolic Blood Pressure	9.4	47.2	213.2	-7.4	1.1	0.3	4.7	7.8	-1.8	-2.8	-5.1	0.8	-12.9	-14.6	-3.3
Systolic blood pressure, automated reading	9.4	27.3	94.5	-6.6	1.9	1.9	4.5	5.2	-1.6	-1.9	-5.3	2.1	-9.7	-9.6	-1.9
Schizophrenia (2018)	8.8	18.2	44.8	-4.4	-3.4	-2.1	6.4	6.7	3.4	3.0	-2.4	1.9	-5.3	-5.8	2.2
Worry (Nagel 2018)	8.5	17.9	45.0	-3.6	-2.8	-3.4	6.7	6.3	3.2	2.4	-0.9	4.2	-4.8	-5.8	2.6
Maternal smoking around birth	8.5	12.2	25.2	-0.8	5.0	4.8	-3.4	-4.5	-4.7	-4.2	-2.4	-2.6	-0.2	0.5	-3.8
Worrier / anxious feelings	8.5	16.1	43.6	-1.4	-3.7	-4.5	5.3	6.6	4.3	3.2	1.4	3.7	-3.3	-4.5	3.2
Current tobacco smoking	8.4	13.8	27.8	-0.9	4.9	5.3	-3.8	-5.1	-5.2	-4.3	-3.2	-1.2	-0.3	1.1	-3.8
Smoking status: Previous	8.2	12.3	23.0	-1.1	4.3	4.6	-2.8	-3.4	-4.7	-4.3	-3.5	-2.5	-1.7	-1.3	-4.8
Diastolic blood pressure, automated reading	8.1	25.0	71.8	-2.8	4.8	4.4	-2.2	0.8	-5.1	-4.2	-4.5	-3.6	-8.5	-8.2	-5.4
Schizophrenia (2014)	7.3	16.1	44.0	-4.1	-2.6	-1.6	5.2	6.6	2.7	2.5	-2.5	1.3	-5.8	-6.2	1.7
Nervous feelings	6.9	12.9	33.0	-3.4	-3.0	-3.1	5.7	5.5	3.1	2.3	-0.2	3.0	-3.5	-4.3	2.7
Bipolar Disorder or Schizophrenia	6.8	16.7	50.5	-3.4	-3.0	-1.9	5.3	7.1	3.2	2.6	-1.5	0.6	-6.1	-6.2	1.5
Vascular/heart problems diagnosed by doctor	6.8	18.5	62.9	3.7	-3.8	-3.4	-0.2	-1.5	3.7	2.6	4.4	2.2	7.9	7.7	3.3
Birth weight	6.6	14.4	52.9	7.3	1.2	1.4	-6.1	-4.1	-1.7	-1.1	2.5	-4.7	3.3	4.0	-1.8
High blood pressure	6.0	16.6	59.4	-3.2	3.3	2.7	-0.1	1.3	-3.8	-2.9	-3.8	-2.4	-7.5	-7.7	-3.5
Coronary Artery Disease (CAD)	5.4	6.4	17.0	-2.8	-0.3	0.4	3.3	4.0	0.7	0.7	-3.2	0.7	-4.1	-3.6	0.4
Hypertension (Self-reported)	5.4	14.9	56.0	-2.9	3.1	2.4	0.0	1.1	-3.6	-2.8	-3.5	-1.8	-7.1	-7.5	-3.2
Risk taking	5.3	7.8	15.6	-0.5	3.9	3.3	-3.6	-2.4	-3.7	-3.8	-2.1	-1.1	-1.1	-0.6	-3.5
Cardiovascular Disease	5.0	16.7	73.4	-2.7	2.7	1.6	-0.1	1.5	-3.5	-2.8	-3.3	-3.7	-7.3	-8.6	-3.1
Alcohol intake versus 10 years previously	5.0	7.4	17.5	-0.9	3.5	4.2	-2.8	-2.5	-3.7	-3.5	-2.4	-0.8	-1.0	0.4	-3.3
Medication: Blood pressure	5.0	9.6	31.4	-2.8	3.0	2.3	-0.3	0.7	-2.8	-2.3	-3.1	-1.5	-5.5	-5.6	-2.4
Pulse wave reflection index	4.7	5.8	15.5	2.2	1.4	2.1	-3.9	-2.3	-1.9	-2.6	1.3	-2.6	2.2	1.4	-3.4
Exposure to tobacco smoke outside home	4.7	6.2	17.4	-0.3	2.6	3.1	-2.2	-4.2	-3.2	-2.7	-2.0	-1.3	1.2	2.2	-2.6
Migraine (self-reported)	4.7	5.8	19.8	3.6	-0.7	-0.3	-2.8	-2.5	-0.4	-1.5	2.9	-1.3	4.5	2.8	-1.2
Schizophrenia vs Biploar Disorder	4.6	6.1	13.7	-3.7	-0.3	0.3	3.1	2.9	0.6	1.1	-3.3	2.6	-3.3	-3.2	1.0
Number of incorrect matches in round	4.6	7.7	19.4	-1.2	-3.3	-3.4	3.3	4.4	3.6	2.7	1.2	2.4	-0.9	-1.5	2.7
Prostate Cancer	4.3	6.1	23.5	-0.0	-2.3	-2.4	3.1	2.6	3.2	2.1	1.3	4.8	0.8	0.4	2.1
Birth weight of first child	4.2	7.7	29.5	3.3	2.3	1.4	-4.1	-5.4	-2.9	-1.2	0.4	-2.5	2.2	2.1	-1.3
Allergy or Eczema	4.1	10.8	41.0	2.2	-2.3	-4.0	1.7	2.8	3.7	3.0	3.0	6.4	2.3	0.8	3.7
Neuroticism	4.1	9.8	26.2	-2.9	-1.3	-2.2	4.8	4.3	1.4	0.5	-1.2	3.7	-4.2	-5.1	0.8
Tense / ‘highly strung’	4.1	6.9	22.9	-2.2	2.3	1.6	1.7	0.9	-1.8	-1.3	-3.7	2.0	-4.8	-4.3	-1.4
Irritability	4.1	6.9	15.6	0.2	4.0	2.8	-2.5	-2.1	-3.9	-3.4	-2.6	-1.1	-2.0	-1.5	-2.9
Unable to work because of sickness or disability	4.1	5.3	12.2	0.9	2.2	1.3	-3.2	-1.4	-3.0	-3.2	-0.1	-1.3	-2.0	-2.6	-3.5
Blood White Count	4.0	29.5	53.0	-3.1	5.9	5.6	-4.5	-4.0	-7.3	-6.2	-6.0	-6.0	-4.6	-4.5	-6.2
Alcohol usually taken with meals	4.0	6.4	13.8	0.0	-3.5	-3.5	3.7	2.1	3.3	2.9	1.9	2.2	0.8	-0.0	2.6
Pulse wave peak to peak time	3.9	4.6	17.7	1.4	0.9	0.5	-2.6	-4.2	-2.5	-2.3	0.4	-1.9	2.0	2.3	-1.7
Illnesses of father: None of the above (group 1)	3.9	4.8	13.8	2.6	-1.9	-2.0	-0.3	-2.5	0.8	1.6	2.8	0.1	3.7	3.0	1.8
Hand grip strength (left)	3.7	9.7	20.9	0.7	2.2	3.4	-3.8	-4.6	-3.6	-4.2	-0.2	-3.6	1.2	1.8	-4.0
Falls in the last year	3.7	5.0	11.9	-1.1	3.5	3.1	-1.1	-0.0	-2.5	-1.8	-2.5	-1.7	-3.3	-1.8	-1.6
Hayfever, allergic rhinitis or eczema	3.6	7.9	26.3	1.7	-2.4	-3.9	1.8	2.1	3.0	2.3	2.9	5.1	2.0	0.2	3.0
Trunk fat-free mass	3.6	20.6	53.7	2.5	2.5	4.0	-6.2	-7.3	-4.5	-3.9	0.5	-6.6	3.4	4.4	-4.1
Trunk predicted mass	3.6	20.4	53.9	2.6	2.5	4.0	-6.2	-7.3	-4.4	-3.8	0.5	-6.5	3.5	4.5	-4.1
Arm predicted mass (right)	3.6	18.3	51.4	1.9	3.0	4.2	-5.7	-7.2	-4.7	-3.5	-0.2	-5.7	2.9	4.0	-3.8
Heart disease (siblings)	3.6	4.4	12.0	-0.2	1.9	2.0	-1.5	0.4	-2.3	-1.7	-2.0	-1.6	-3.5	-2.9	-2.8
Major Depression (MDD)	3.5	4.3	18.1	-1.9	0.8	0.8	1.6	2.4	-0.4	-0.7	-1.7	-1.1	-4.3	-3.7	-1.1
Leg fat-free mass (left)	3.5	18.3	56.2	2.5	2.7	3.2	-5.5	-7.5	-3.3	-1.9	0.7	-4.4	5.2	6.9	-1.2
Heart attack	3.5	4.5	15.8	-2.6	2.0	2.3	0.6	1.6	-1.0	-0.5	-3.4	-0.1	-4.0	-2.5	-0.4
Arm fat-free mass (right)	3.5	18.0	49.8	1.8	3.0	4.4	-5.6	-7.1	-4.5	-3.4	-0.3	-5.8	2.9	4.1	-3.7
Whole body fat-free mass	3.5	20.0	58.2	2.6	2.6	3.7	-6.0	-7.6	-4.1	-3.0	0.6	-5.7	4.3	5.6	-3.0
Leg fat-free mass (right)	3.5	19.0	58.5	3.0	2.8	3.1	-5.7	-7.7	-3.5	-1.8	0.8	-4.6	5.1	6.7	-1.3
Leg predicted mass (right)	3.5	18.9	57.9	3.0	2.7	3.1	-5.7	-7.6	-3.4	-1.7	0.9	-4.6	5.2	6.7	-1.3
High blood pressure (mother)	3.4	4.7	24.5	-1.8	0.4	0.0	1.4	1.9	-0.6	-0.0	-1.8	1.5	-4.1	-4.9	-0.7
Leg predicted mass (left)	3.4	18.0	55.6	2.4	2.7	3.2	-5.4	-7.5	-3.4	-1.9	0.6	-4.4	5.1	6.7	-1.3
Hearing difficulty/problems with background noise	3.4	5.5	13.6	0.9	1.2	1.2	-2.8	-2.7	-3.3	-3.1	-0.9	-2.9	-1.3	-1.4	-3.7
Mouth/teeth dental problems	3.4	5.2	13.5	-0.6	-3.0	-2.6	3.7	2.4	3.1	2.2	1.2	2.1	0.6	-0.3	2.4
Peak expiratory flow (PEF)	3.4	8.0	19.1	-0.5	2.2	3.2	-3.0	-4.4	-3.5	-3.8	-2.1	-2.6	0.2	1.2	-3.6
Whole body water mass	3.4	19.3	57.0	2.5	2.6	3.7	-5.8	-7.5	-4.0	-2.9	0.6	-5.6	4.3	5.5	-2.9
Heart attack/myocardial infarction (self-reported)	3.4	4.4	15.5	-2.5	2.1	2.2	0.5	1.5	-1.1	-0.6	-3.4	-0.2	-3.9	-2.5	-0.4
Ulcerative Colitis	3.3	4.9	24.7	1.7	0.6	0.8	-2.7	-1.1	-2.3	-2.2	0.1	-5.0	-1.2	-1.7	-2.6
Angina (self-reported)	3.3	4.3	9.9	-2.4	1.8	2.3	0.8	0.9	-1.5	-1.3	-3.0	-0.7	-3.1	-3.1	-1.7
Suffer from ‘nerves’	3.3	5.2	13.4	-1.6	-1.5	-1.7	3.4	3.7	1.8	1.4	-0.1	1.3	-3.4	-3.3	1.1
Back pain experienced in last month	3.3	4.8	9.1	-1.1	2.6	3.0	-1.3	-1.5	-2.8	-2.2	-2.9	-1.0	-2.4	-1.7	-2.4
Mineral and other dietary supplements	3.3	4.4	11.1	0.3	-2.5	-3.3	1.9	2.8	2.8	2.3	1.9	1.2	-0.3	-0.8	2.2
Basal metabolic rate	3.3	18.5	56.5	2.3	2.7	3.5	-5.7	-7.5	-4.0	-2.8	0.4	-5.3	4.2	5.6	-2.6
Neuroticism (Nagel 2018)	3.2	7.5	18.1	-3.0	-0.8	-1.8	4.3	4.1	1.3	0.9	-1.2	2.7	-3.8	-3.9	1.4
Age at First Birth	3.2	4.6	15.6	3.4	-1.8	-2.1	-0.7	-0.9	1.4	2.0	3.9	-0.9	2.7	1.7	1.5
Townsend deprivation index at recruitment	3.2	4.5	10.6	0.1	2.3	2.0	-2.8	-3.2	-2.8	-2.6	-1.0	-1.8	0.9	1.5	-2.1
Arm fat-free mass (left)	3.2	16.1	49.6	1.9	2.7	3.8	-5.1	-7.0	-4.0	-2.9	-0.1	-5.2	3.2	4.4	-3.1
Arm predicted mass (left)	3.2	16.3	50.1	1.8	2.5	3.7	-5.1	-7.1	-4.1	-3.1	0.1	-5.3	3.4	4.5	-3.2
Illnesses of siblings	3.1	4.4	9.2	1.4	-2.3	-3.0	1.6	0.0	2.5	2.0	1.9	1.5	2.6	2.2	2.3
Vitamin and mineral supplements	3.0	4.1	11.4	0.4	-2.4	-3.4	1.9	2.1	2.3	2.4	1.7	0.4	0.0	-0.2	3.1
Pulse wave Arterial Stiffness index	3.0	3.5	14.8	-1.2	-1.1	-0.5	2.1	3.9	2.4	2.2	-0.1	1.0	-1.6	-1.9	1.5
Forced expiratory volume in 1-second (FEV1), predicted	3.0	6.3	23.6	0.7	0.8	1.7	-3.1	-4.0	-2.7	-2.6	0.2	-4.9	0.9	1.4	-2.1
Financial situation satisfaction	3.0	3.7	10.1	1.0	1.8	1.0	-2.8	-3.2	-2.7	-2.2	0.2	-2.2	0.6	1.0	-1.6
Body Mass Index (BMI) (2010)	2.9	4.0	16.2	-0.8	1.7	2.3	-1.2	-3.3	-1.5	-0.4	-0.8	1.1	2.5	4.0	0.4
Allergy	2.9	6.7	22.4	-0.0	1.8	3.0	-2.5	-2.6	-3.0	-2.1	-2.2	-4.7	-2.0	-0.8	-3.2
Weight	2.9	14.1	48.0	1.1	3.1	3.5	-4.5	-6.9	-3.8	-2.4	-0.7	-3.6	3.6	5.4	-1.8
Standing height	2.9	29.1	132.2	2.4	0.7	2.4	-7.1	-7.2	-5.2	-5.5	1.0	-11.5	1.9	2.7	-5.8
Worry too long after embarrassment	2.9	4.8	15.8	-3.6	-0.4	-0.6	4.0	2.1	0.9	0.6	-1.4	3.1	-2.3	-2.2	1.1
Medication for cholesterol	2.9	4.3	14.7	2.1	-2.0	-1.1	0.9	-1.4	1.5	1.3	1.8	1.9	3.8	3.6	1.0
Medication: Bendroflumethiazide	2.8	4.3	9.7	-1.9	2.0	1.8	-1.3	-0.4	-2.5	-1.3	-1.4	-2.8	-3.1	-2.8	-1.6
Supplements: Zinc	2.7	2.9	5.7	-0.3	2.0	2.2	-1.8	-2.2	-2.4	-2.3	-1.2	-0.4	-0.1	0.0	-2.2
Height	2.6	49.9	231.0	2.8	0.8	3.8	-9.0	-9.5	-6.5	-6.8	2.1	-15.2	2.5	4.5	-7.3
Angina	2.6	3.4	7.9	-1.9	1.7	2.1	0.6	0.6	-1.5	-1.4	-2.5	-0.9	-2.7	-2.8	-1.7
Hand grip strength (right)	2.6	7.0	15.9	-0.2	2.2	3.5	-2.6	-4.0	-3.2	-3.7	-1.2	-2.0	0.9	2.0	-3.2
High blood pressure (siblings)	2.6	3.7	10.9	-1.3	1.7	2.1	-0.7	1.2	-1.6	-1.3	-1.3	-1.4	-3.3	-3.3	-1.9
Bipolar Disorder (2011)	2.5	2.4	8.0	-0.3	-0.1	-0.3	0.6	2.3	0.2	-0.7	-1.7	-1.6	-2.8	-2.8	-1.1
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.8	20.1	-0.9	0.8	-0.5	1.2	1.3	-1.0	-1.5	-1.4	1.8	-3.3	-4.5	-1.3
Forced vital capacity (FVC)	2.5	9.7	22.1	-1.1	1.9	3.2	-3.0	-2.7	-3.9	-4.3	-2.5	-3.6	-2.5	-1.9	-4.7
Neuroticism score	2.5	5.2	13.7	-1.5	-0.7	-1.5	3.7	3.3	1.1	0.4	-0.6	3.0	-3.2	-3.4	0.8
Average weekly champagne plus white wine intake	2.5	3.4	9.0	2.6	-2.1	-2.2	0.1	-1.3	0.6	0.4	2.4	1.7	3.0	2.1	0.1
Pack years of smoking	2.5	3.7	8.2	-1.5	2.3	1.9	-0.9	-2.6	-2.9	-2.6	-2.5	-0.2	-0.8	0.3	-1.9
Pack years adult smoking proportion	2.4	3.7	8.7	-1.5	2.2	1.7	-0.9	-2.8	-2.9	-2.7	-2.4	-0.0	-0.7	0.4	-1.7
Medication: Ramipril	2.4	3.1	11.4	-1.8	-0.1	0.1	1.1	3.2	0.7	1.0	-0.6	0.3	-3.4	-3.1	-0.3
Hip circumference	2.4	10.2	36.3	1.0	2.9	2.9	-3.9	-6.0	-3.2	-1.8	-1.0	-1.7	3.4	4.8	-1.1
Number of full brothers	2.4	3.0	5.4	-0.4	2.2	1.9	-2.3	-0.9	-2.3	-2.0	-1.5	-0.6	-1.9	-1.4	-2.2
Illnesses of father: Heart disease	2.4	3.3	9.5	-1.9	1.1	1.4	1.2	1.7	-0.0	-0.4	-2.9	-1.3	-2.8	-3.1	-0.8
Crohns Disease (2012)	2.3	3.7	7.1	-2.7	2.0	2.6	-0.2	-1.7	-2.5	-1.9	-2.4	-2.2	-1.2	0.0	-1.2
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	6.7	-0.7	1.6	1.6	-1.6	-1.8	-1.9	-2.0	-1.3	-2.6	0.1	-0.2	-1.7
Average weekly fortified wine intake	2.3	2.7	6.4	0.3	-2.0	-1.7	1.5	1.8	2.5	2.0	1.2	-0.1	1.6	1.1	2.1
Sitting height	2.3	16.3	96.8	1.4	0.9	1.7	-4.7	-3.8	-4.0	-3.6	-0.1	-9.8	-2.1	-1.7	-4.5
Financial difficulties in last 2 years	2.3	3.0	11.2	-1.1	1.4	1.5	-1.5	-2.0	-2.7	-3.3	-0.9	0.3	-1.0	-0.2	-2.1
Mouth/teeth dental problems: Dentures	2.3	3.9	8.5	0.1	1.9	2.4	-2.7	-2.9	-2.6	-2.1	-0.6	-1.7	0.5	1.0	-2.4
Qualifications: College or University degree	2.3	7.2	16.2	-1.2	-4.0	-3.5	3.9	2.6	3.4	2.9	1.5	1.4	1.0	-0.0	3.1
Neck or shoulder pain in last month	2.3	3.3	9.4	-2.2	1.2	0.8	0.4	0.4	-1.6	-1.7	-2.8	0.9	-3.1	-2.7	-1.2
Knee pain experienced in last month	2.3	3.5	10.1	0.1	2.8	3.2	-2.7	-1.8	-2.0	-1.0	-2.0	-0.9	0.1	1.2	-1.5
Pain type(s) experienced in last month: Hip pain	2.3	2.9	11.7	-2.1	1.4	1.7	1.4	0.3	-0.8	-0.6	-2.8	3.4	-1.4	-1.0	-0.3
Fractured/broken bones in last 5 years	2.3	2.9	7.5	-2.7	-0.1	-0.1	2.4	1.6	0.5	1.0	-2.3	2.7	-1.5	-1.5	1.0
Impedance of leg (right)	2.2	10.5	40.0	-3.4	-2.1	-2.0	2.9	4.3	0.3	-1.5	-1.4	-0.6	-5.6	-6.3	-1.6
Forced expiratory volume in 1-second (FEV1)	2.2	7.5	18.2	-1.3	1.7	2.9	-3.0	-2.6	-3.5	-4.0	-2.3	-2.1	-1.9	-1.2	-4.3
Pulse rate	2.2	3.7	9.5	-1.1	-1.5	-1.8	3.1	2.6	2.0	2.1	-0.5	2.1	-0.8	-0.7	2.7
Reaction Time	2.1	4.0	11.1	-1.0	-0.1	-0.9	2.1	3.0	1.6	2.1	-1.3	3.3	-2.1	-1.6	2.3
Hearing difficulty/problems: Yes	2.1	3.2	6.5	1.0	1.3	1.4	-2.2	-1.1	-2.2	-2.1	-0.8	-2.5	-1.4	-1.8	-2.6
Supplements: Glucosamine	2.1	2.7	8.4	-0.5	2.4	2.9	-0.8	-1.2	-2.0	-1.9	-1.8	-0.8	-0.7	-0.5	-1.9
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	8.3	1.2	-0.8	-0.9	0.1	-0.3	1.5	2.2	2.0	0.6	2.9	2.1	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	7.2	-1.1	2.1	2.7	-1.2	0.0	-1.7	-1.9	-1.1	-0.4	-2.1	-0.6	-1.7
Medication: Aspirin	2.1	2.7	10.4	-0.0	1.4	1.2	-0.6	0.5	-1.2	-0.4	-1.3	-2.4	-3.2	-2.7	-1.1
Medication: Atorvastatin	2.1	2.7	8.2	-0.1	1.3	0.6	-0.5	-0.1	-1.9	-1.8	-1.5	-1.1	-2.7	-2.9	-2.0
Supplements: Calcium	2.1	2.3	5.5	-0.5	2.0	1.3	-0.4	-2.2	-2.3	-1.5	-2.0	1.9	-0.8	-0.7	-0.9
Ulcerative Colitis (UC)	2.0	3.7	15.4	3.0	0.6	0.8	-2.8	-0.3	-1.3	-1.6	1.0	-3.9	-0.9	-1.0	-2.0
Type 2 Diabetes (T2D) (2018)	2.0	3.7	11.1	-2.1	2.1	3.2	-0.0	-3.3	-1.0	1.0	-1.7	-1.3	0.9	2.5	0.9
Relative age of first facial hair	2.0	4.1	9.8	-1.5	1.9	1.3	-2.9	-2.3	-3.1	-2.7	-1.9	-1.7	0.2	1.0	-1.7
Serious illness, injury or assault to yourself	2.0	2.4	8.8	-3.0	0.8	0.5	1.1	0.7	-0.7	-0.8	-2.1	1.7	-2.4	-1.8	-0.4
Medication: Atenolol	2.0	2.5	7.0	-1.2	1.4	1.1	0.1	-0.6	-1.5	-0.7	-2.4	-1.1	-2.6	-2.6	-1.0
Impedance of leg (left)	2.0	9.9	42.8	-2.7	-1.4	-1.6	2.5	3.7	-0.2	-1.5	-1.7	-1.1	-5.8	-6.5	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.5	12.6	0.2	-3.5	-1.9	0.7	1.2	2.7	1.3	2.8	-2.4	2.4	2.5	1.3
Age at first live birth	2.0	3.6	12.0	2.6	-1.4	-1.5	0.8	-0.2	2.2	3.5	1.7	-0.1	2.0	1.8	2.1
Heart disease (mother)	2.0	2.4	7.8	-1.5	-0.7	-0.8	2.8	2.7	1.4	0.9	-0.7	0.9	-1.9	-0.9	1.4
Leg fat mass (left)	2.0	7.6	27.4	-0.1	3.2	3.2	-2.5	-5.2	-2.9	-1.4	-1.6	-1.4	2.4	4.0	-0.9
Type 2 Diabetes (T2D) (2012)	1.9	2.2	6.3	-1.7	-2.5	-2.1	1.3	1.7	1.2	0.8	-0.2	-1.4	0.1	0.6	2.0
Heel T-Score	1.9	15.5	30.5	2.5	-5.0	-3.2	0.5	1.4	4.8	3.2	5.2	-3.7	5.4	5.5	2.8
Number of treatments/medications taken	1.9	3.5	10.3	-1.4	1.6	2.0	-0.7	2.0	-1.3	-1.7	-1.2	-0.7	-3.2	-2.5	-2.4
Average weekly spirits intake	1.9	2.3	10.5	-3.2	1.1	1.7	1.3	-0.4	-0.4	-1.0	-2.5	0.6	0.6	1.8	0.4
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	6.3	-0.3	-1.7	-0.9	2.5	2.0	2.0	1.4	0.7	1.4	0.6	0.2	2.1
Waist circumference	1.9	7.1	20.7	-1.0	2.8	3.3	-2.6	-4.5	-2.9	-1.6	-1.9	-2.1	1.9	3.7	-1.2
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	8.2	1.1	-1.6	-2.5	0.2	1.1	1.4	1.4	2.9	1.4	1.4	0.3	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	11.3	-1.0	-0.1	-0.6	0.9	2.4	-0.1	-0.6	-0.8	0.7	-2.9	-3.4	-0.6
Leg fat mass (right)	1.9	7.2	25.9	-0.3	2.9	3.0	-2.3	-5.1	-2.8	-1.5	-1.5	-1.2	2.5	4.1	-0.8
Comparative height size at age 10	1.9	10.7	48.0	1.7	-1.4	1.6	-3.6	-3.9	-1.4	-2.1	1.7	-6.9	3.3	3.9	-3.1
Chest pain or discomfort	1.9	2.8	5.6	0.4	2.2	1.7	-1.3	-0.3	-1.9	-2.4	-0.8	-0.6	-1.6	-2.4	-2.3
Family relationship satisfaction	1.9	2.3	6.6	-0.9	1.4	1.4	0.1	-1.1	-2.0	-1.8	-2.6	0.3	-1.9	-1.0	-1.8
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	6.3	-1.3	2.5	2.2	-1.1	-1.2	-1.9	-0.7	-2.4	-0.5	-1.0	-0.2	-1.1
Commuting to job workplace: Car/motor vehicle	1.9	2.2	6.9	2.0	1.3	0.5	-2.6	-2.1	-1.8	-1.7	0.5	-0.1	0.9	-0.2	-1.5
Illnesses of father: High blood pressure	1.9	2.4	9.3	-1.2	1.2	0.5	0.5	0.7	-1.2	-2.0	-1.3	0.3	-2.3	-3.0	-1.7
Blood Platelet Count	1.8	21.4	69.7	-0.4	4.7	3.8	-7.0	-4.1	-5.7	-4.7	-3.3	-8.3	-0.4	0.4	-4.3
Blood Red Count	1.8	16.9	62.7	3.1	-0.5	-0.7	-3.8	2.5	-2.6	-4.0	2.0	-4.0	-5.3	-7.9	-6.2
Sensitivity / hurt feelings	1.8	3.0	8.6	-2.9	-0.8	-0.9	2.6	2.5	1.0	1.1	-0.8	1.5	-1.9	-1.8	1.2
Severe depression (siblings)	1.8	2.0	5.2	-2.3	0.6	0.4	-0.1	1.4	-0.7	-0.9	-1.9	0.9	-2.3	-2.1	-1.1
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	8.5	0.4	-0.1	-0.1	0.9	2.9	0.9	0.7	-0.3	1.0	-2.7	-2.4	-0.3
Qualifications: None of the above	1.8	3.9	8.4	-1.1	2.7	2.9	-1.5	-1.6	-2.7	-2.0	-2.6	0.1	-1.7	-0.7	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	8.6	-2.8	0.2	-0.0	0.2	2.1	-0.8	-1.6	-1.2	-0.6	-2.3	-2.9	-1.0
Medication: Blood pressure	1.8	3.1	13.8	-0.3	1.3	0.8	-0.7	0.9	-1.4	-0.4	-0.5	-1.6	-3.6	-3.7	-1.4
Ever had bowel cancer screening	1.8	2.1	9.8	0.6	0.9	1.3	-1.5	-0.3	-1.2	-1.6	-0.5	-3.1	-1.4	-1.0	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	6.4	-1.1	-1.6	-1.4	1.5	2.5	2.2	1.5	1.0	1.6	-0.1	0.2	1.8
BMI	1.7	10.1	39.3	0.5	2.8	2.6	-1.3	-5.6	-1.2	0.2	-0.7	1.9	5.2	6.3	1.4
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	4.8	-0.5	1.6	2.2	-1.1	-0.7	-1.9	-1.7	-1.4	0.7	-0.2	-0.5	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.6	14.6	-0.6	1.5	2.5	-2.6	-2.0	-2.9	-3.8	-1.7	-1.7	-1.8	-1.0	-3.8
Blood clot in the leg (DVT)	1.7	2.2	5.5	-1.6	-1.4	-1.1	1.5	2.3	2.1	1.4	0.6	1.6	-0.0	0.4	1.7
Forced vital capacity (FVC), Best measure	1.7	6.0	15.4	-0.5	1.2	2.4	-2.4	-1.9	-2.9	-3.9	-1.4	-2.9	-2.1	-1.4	-3.9
Whole body fat mass	1.7	7.1	24.5	-0.4	2.9	2.8	-2.3	-5.0	-2.5	-0.7	-1.5	-1.1	2.6	4.7	0.1
Medication: Aspirin	1.7	2.3	9.1	0.2	1.4	1.1	-0.4	0.3	-1.1	-0.1	-1.0	-2.4	-3.0	-2.4	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	6.1	-1.1	1.8	2.5	0.1	1.1	-0.3	-1.0	-1.8	-1.5	-1.8	-1.0	-1.2
Commuting to job workplace: Walk	1.7	1.8	8.8	-0.7	0.8	0.8	0.9	1.5	-0.3	0.7	-1.1	0.7	-3.0	-2.4	-0.2
Osteoarthritis (self-reported)	1.7	2.2	5.6	-1.5	1.5	2.4	-0.3	1.1	-0.8	-1.2	-1.6	0.4	-2.1	-2.0	-1.6
Bipolar Disorder (2018)	1.6	2.5	10.3	0.0	-0.6	-0.4	0.4	3.0	0.8	0.4	0.1	-1.3	-3.2	-2.7	-0.4
Chronotype (morning person)	1.6	3.6	22.4	4.7	0.2	-0.7	-1.6	-1.7	-0.7	-1.5	2.6	-0.2	0.8	-0.6	-2.1
Age when periods started (menarche)	1.6	3.7	9.2	1.1	2.3	1.7	-3.0	-2.5	-1.7	-0.9	-0.5	-2.1	1.7	2.9	-0.8
Trunk fat mass	1.6	7.0	24.8	-0.1	2.5	2.5	-2.4	-4.9	-2.2	-0.6	-1.0	-1.5	2.9	5.0	0.3
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	6.4	1.8	2.0	1.0	-2.5	-1.9	-1.8	-1.0	-0.5	-1.1	-0.3	0.7	-0.9
Illnesses of siblings: Diabetes	1.6	1.9	5.8	0.7	-0.6	-0.9	-0.6	-1.4	0.2	0.8	1.8	-1.7	2.0	2.4	1.5
Long-standing illness, disability or infirmity	1.6	2.5	5.8	0.2	1.5	1.2	-1.8	-0.8	-2.1	-1.7	-0.9	-1.6	-1.7	-1.6	-2.4
Supplements: Fish oil (including cod liver oil)	1.6	2.1	5.8	-0.3	1.8	2.4	-1.2	-1.4	-2.0	-1.4	-1.7	-0.8	-0.4	0.1	-1.5
Crohns Disease (2017)	1.5	3.3	11.1	-1.6	2.1	3.3	-0.8	-0.7	-2.0	-1.3	-2.1	-2.0	-1.8	-0.5	-1.8
Irritable Bowel Disease (IBD)	1.5	3.5	15.5	0.8	1.5	2.2	-2.0	-0.1	-1.8	-1.7	-0.7	-3.9	-1.8	-1.2	-2.1
Neuroticism (2016)	1.5	2.2	8.7	-0.3	1.1	0.3	1.1	2.3	0.1	0.9	-0.1	1.7	-3.0	-2.5	0.3
Rheumatoid Arthritis	1.5	2.1	4.2	0.3	1.6	1.3	-2.0	-1.8	-2.1	-1.7	-1.3	-0.8	-0.8	-0.2	-2.0
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	4.6	-0.5	0.9	1.0	-1.0	-0.8	-1.9	-2.1	-1.0	-0.6	-1.3	-1.7	-2.1
Fluid intelligence score	1.5	3.1	9.6	2.6	-1.6	-1.8	-0.1	-2.0	0.1	-0.4	2.6	-1.0	3.1	1.6	0.1
Number of live births	1.5	2.2	5.6	-2.2	-0.4	0.1	2.4	2.3	1.0	0.9	-1.0	0.6	-1.7	-1.8	0.9
Breastfed as a baby	1.5	1.8	4.3	0.5	-2.1	-1.7	0.9	2.0	1.3	1.2	0.9	0.6	-1.2	-2.0	-0.2
Ever highly irritable/argumentative for 2 days	1.5	1.7	5.6	-0.1	-0.6	-0.6	-0.5	0.7	-0.7	-2.2	0.7	-1.6	-1.4	-2.4	-1.9
Medication for cholesterol, blood pressure or diabetes	1.5	2.6	10.1	0.3	-1.9	-1.4	0.4	-0.2	1.6	0.1	0.5	1.2	3.2	3.2	1.0
Medication: Ventolin 100micrograms inhaler	1.5	1.9	5.7	-1.0	-1.2	-1.4	1.6	1.5	1.9	1.5	0.7	0.5	0.8	1.0	2.4
Comparative body size at age 10	1.5	4.0	11.7	-1.9	1.5	2.4	2.0	-2.5	-0.3	0.7	-2.3	1.9	1.4	3.4	1.6
Supplements: Vitamin C	1.5	1.8	7.3	-0.2	2.1	2.7	-1.4	-0.8	-1.2	-0.8	-0.8	-0.8	-0.8	1.0	-1.2
Diabetes diagnosed by doctor	1.5	2.4	8.6	-1.6	1.6	2.2	-0.4	-2.9	-0.9	0.6	-1.3	-1.2	1.1	2.1	0.6
Arm fat mass (left)	1.5	6.3	22.0	-0.1	2.8	2.6	-2.1	-4.5	-2.0	-0.4	-1.2	-0.6	2.8	4.7	0.5
Commuting to job workplace: Public transport	1.5	1.8	4.8	-0.8	-2.2	-1.9	1.9	1.2	1.7	1.2	0.7	0.2	0.7	0.1	1.3
Eye problems/disorders: Glaucoma	1.5	1.8	9.0	-1.8	-1.2	0.1	3.0	1.3	1.1	1.1	-0.3	1.5	-0.9	-0.0	1.0
Lupus	1.4	2.2	6.6	2.2	0.2	-0.2	-2.6	-1.8	-1.4	-1.8	0.8	-1.2	1.1	0.4	-1.6
Lung FEV1/FVC ratio	1.4	7.1	11.2	-0.3	2.4	3.2	-3.4	-3.0	-3.0	-3.3	-2.4	2.3	1.2	2.8	-2.9
Lung FVC	1.4	7.0	16.8	-2.9	1.5	2.5	1.0	1.5	-1.3	-1.8	-3.3	3.2	-4.0	-4.1	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.3	9.0	-0.4	-3.0	-1.5	1.4	1.3	2.6	1.6	1.7	-1.8	1.6	2.0	1.6
Body mass index (BMI)	1.4	5.8	20.7	0.0	2.9	2.5	-1.5	-4.0	-1.6	0.0	-1.2	1.5	3.1	4.5	0.8
Had menopause	1.4	1.8	7.2	-0.2	-0.7	-0.6	1.5	2.7	1.0	0.6	-0.5	1.7	-1.6	-2.1	-0.0
Hair/balding pattern: Pattern 3	1.4	2.1	5.3	-0.2	1.3	1.4	-0.3	0.2	-1.2	-1.1	-1.1	-1.4	-2.2	-2.3	-2.2
Lung cancer (father)	1.4	1.6	6.2	1.3	-1.0	-0.0	-0.4	-1.3	0.4	0.8	0.8	-1.7	2.5	1.9	0.4
Arm fat mass (right)	1.4	5.7	21.6	0.2	2.3	2.0	-2.0	-4.4	-1.8	-0.2	-0.8	-0.4	3.0	4.6	0.8
Mean time to correctly identify matches	1.4	2.7	6.4	-1.1	0.1	0.3	1.8	2.3	0.9	1.7	-1.8	2.1	-2.5	-1.6	1.2
Had major operations	1.4	1.6	4.4	-1.3	1.0	1.4	-0.4	-1.6	-1.6	-2.1	-1.1	0.8	0.4	0.7	-1.6
Qualifications: nursing, teaching	1.4	2.1	8.2	-1.2	-2.3	-0.6	2.9	1.2	1.8	1.6	0.6	0.0	1.1	0.6	1.2
Impedance of whole body	1.4	7.1	20.5	-2.0	-2.1	-3.1	2.8	4.1	1.2	0.3	-0.8	-0.0	-4.3	-4.5	0.7
Depression (Nagel 2018)	1.3	2.0	8.1	-0.8	0.5	-0.6	1.2	1.5	-0.6	-0.9	-0.9	0.8	-2.8	-2.8	-0.4
HDL Cholesterol	1.3	2.1	8.0	-0.6	-2.3	-1.9	2.8	1.3	1.7	0.9	-0.0	1.2	0.0	-0.5	1.2
Ever had hysterectomy (womb removed)	1.3	1.5	4.0	1.3	-1.8	-1.4	0.5	1.6	1.6	0.8	2.0	1.1	0.4	-0.1	0.3
Relative age voice broke	1.3	1.9	4.8	-1.8	1.1	1.3	-0.7	-0.5	-1.8	-2.2	-1.9	-0.7	-1.4	-0.3	-1.5
Diabetes (self-reported)	1.3	2.0	7.6	-1.5	1.1	1.8	-0.3	-2.8	-0.6	0.8	-0.9	-1.2	1.1	2.1	0.9
Medication: Paracetamol	1.3	2.1	10.9	-2.7	-0.5	0.1	0.6	3.3	0.6	-1.1	-0.5	0.5	-1.7	-1.0	-0.5
Glaucoma (self-reported)	1.3	1.6	5.0	-2.0	0.0	0.7	2.2	0.8	0.3	0.8	-1.2	1.8	-1.6	-0.7	0.5
Overall health rating	1.3	2.7	6.2	0.1	2.3	1.7	-1.2	-1.6	-2.5	-1.7	-2.1	0.7	-1.0	-1.5	-1.7
Eye problems/disorders: Cataract	1.3	1.5	3.9	-0.3	-2.0	-1.8	-0.1	-0.7	0.5	-0.2	2.0	-0.8	2.0	1.2	0.4
Cholesterol lowering medication	1.3	1.9	5.4	-2.3	0.9	1.5	0.5	1.0	-0.7	-0.1	-2.1	-0.2	-2.2	-1.7	-0.3
Verbal and Numeric Reasoning (VNR)	1.2	2.8	11.5	3.4	-0.6	-1.3	-1.0	-2.5	-0.8	-0.4	2.6	-1.2	1.7	0.9	-0.4
Diabetes (mother)	1.2	1.5	5.5	-1.0	0.1	0.7	-1.0	-1.4	-0.6	-0.5	-0.7	-2.4	1.8	1.8	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	5.1	-0.4	-0.4	-0.3	-1.6	0.1	-1.0	-1.3	0.5	-2.2	-0.5	-1.7	-1.7
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.9	-1.0	1.7	2.0	-1.2	-1.4	-1.0	0.2	-1.1	-0.7	0.2	1.7	0.2
Average weekly red wine intake	1.2	1.7	5.2	-0.7	-0.3	-0.6	1.8	1.6	1.5	2.3	-0.6	0.1	-1.2	-0.6	2.2
Osteoporosis (self-reported)	1.2	1.5	3.4	-1.4	1.0	1.2	0.7	0.4	-0.9	-0.7	-1.3	1.8	-1.8	-1.5	-1.2
Ever taken oral contraceptive pill	1.2	1.3	7.0	0.0	-0.0	0.2	-0.5	-1.1	0.3	-0.6	0.0	-0.7	2.5	2.6	-0.2
Medication: Paracetamol	1.2	1.8	9.7	-2.1	-0.7	-0.0	0.8	3.1	0.7	-1.0	-0.2	0.2	-1.7	-1.3	-0.6
Medication: Lisinopril	1.2	1.5	5.1	-1.7	0.1	0.2	0.5	1.5	-0.2	-0.3	-0.7	-1.4	-2.1	-2.3	-0.2
Breast Cancer	1.1	2.7	6.9	-0.0	-1.7	-1.6	1.9	1.2	2.4	2.6	1.1	0.5	1.0	0.6	2.5
Medication: Co-codamol	1.1	1.3	4.2	-1.7	0.6	0.6	1.2	0.7	-0.8	-1.2	-1.2	0.9	-2.0	-1.2	-0.3
Multivitamins +/- minerals	1.1	1.3	4.3	0.2	1.0	1.4	-1.5	-1.2	-1.2	-1.5	-1.0	-0.5	0.4	-0.2	-2.1
Father’s age at death	1.1	1.5	6.3	0.1	-1.7	-1.2	2.5	0.5	1.5	1.1	0.9	0.8	0.4	0.9	0.9
Qualifications: A levels/AS levels or equivalent	1.1	2.5	9.4	0.5	-2.4	-3.1	1.1	-0.2	1.2	1.1	2.0	-1.1	1.8	0.1	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	6.8	-1.5	-0.8	-0.8	1.4	1.4	1.3	0.2	-0.1	2.6	0.5	0.5	0.8
Illnesses of mother	1.1	1.4	5.9	0.7	-0.6	0.0	-0.7	-0.6	0.8	0.5	1.9	-0.1	2.1	2.4	0.4
Medication: Amlodipine	1.1	1.6	9.6	-0.3	0.4	-0.8	1.1	0.8	-0.5	-0.2	-0.4	0.9	-2.3	-3.1	0.3
Medication for pain relief, constipation, heartburn	1.1	1.9	9.9	2.1	0.6	0.2	-1.0	-3.1	-1.1	0.1	0.2	-0.7	1.9	1.0	-0.3
Pulse rate, automated reading	1.1	3.7	8.2	-0.5	-1.3	-2.7	2.4	2.9	1.0	1.1	-0.4	0.7	-2.4	-2.9	1.9
Friendships satisfaction	1.1	1.3	2.5	0.4	-1.2	-0.9	1.6	-0.2	1.1	1.2	0.9	1.5	1.3	0.8	1.5
Medication: Gliclazide	1.1	1.2	3.6	-1.6	1.4	1.6	1.1	-1.0	-0.3	0.9	-1.9	0.4	-1.1	0.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	6.9	-1.2	-0.9	0.4	1.0	0.1	-0.6	-2.4	-1.2	2.2	-1.2	-2.0	-2.6
Medication: Metformin	1.0	1.4	5.4	-0.3	1.2	1.6	-0.5	-2.3	-0.4	0.5	-0.6	-0.6	1.6	1.9	0.2
Arm fat percentage (right)	1.0	4.1	17.9	-0.5	2.2	1.3	-0.6	-3.1	-0.7	0.8	-1.1	1.5	2.5	4.2	2.0
Happiness	1.0	1.2	3.0	-1.0	-0.8	-0.2	1.7	1.7	1.3	1.0	-0.2	1.7	0.0	0.7	1.1
Length of working week for main job	1.0	1.2	5.7	-1.2	0.3	0.4	-0.7	-1.6	-1.2	-0.8	-0.6	-2.4	0.3	1.0	-0.2
Arm fat percentage (left)	1.0	4.1	17.0	-0.6	2.4	1.6	-0.5	-2.9	-0.8	0.8	-1.4	1.6	2.2	4.1	2.0
Intelligence (Savage-Jansen 2018)	0.9	2.8	11.4	3.4	-0.8	-1.3	-0.7	-1.4	-0.1	0.5	3.3	-2.1	1.1	0.4	-0.2
HbA1C	0.9	1.0	3.3	-0.8	-0.5	-0.0	1.1	1.8	1.0	1.5	0.3	0.7	-1.3	-0.4	0.9
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	5.5	0.1	0.3	-0.8	-0.7	1.0	-0.6	-0.9	-0.6	-0.5	-1.8	-2.3	-1.0
Medication for hormone replacement therapy	0.9	1.0	3.8	0.1	0.2	-0.4	-1.9	0.4	-0.6	-1.9	0.6	-1.5	0.5	0.4	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.8	-0.0	1.5	0.8	-0.4	-0.7	-1.6	-1.7	-0.8	0.5	-1.2	-1.0	-1.4
Chronic bronchitis/emphysema (father)	0.9	1.0	5.1	-2.3	-0.1	0.6	1.0	1.5	0.7	0.9	-0.4	0.5	-1.0	0.3	0.8
Impedance of arm (right)	0.9	4.4	11.5	-1.1	-2.0	-3.3	2.2	3.4	1.9	1.5	-0.2	0.7	-2.3	-1.8	2.4
Impedance of arm (left)	0.9	4.4	13.0	-1.1	-1.8	-3.0	2.0	3.6	1.7	1.4	-0.3	0.7	-2.6	-2.1	2.3
Exposure to tobacco smoke at home	0.9	1.0	4.0	0.1	0.7	-0.2	-0.1	-2.0	-0.5	0.2	-0.2	0.8	1.5	2.0	0.8
Chronic bronchitis/emphysema (mother)	0.9	1.0	5.0	0.8	0.7	0.5	-1.0	-1.0	-0.7	-1.1	0.1	-2.2	0.4	0.9	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	3.8	-0.3	0.7	-0.0	-1.4	-1.9	-1.9	-1.4	0.0	0.1	-0.1	-0.1	-0.8
Age at last live birth	0.9	1.4	6.7	1.1	0.5	0.2	0.5	-0.5	1.0	2.6	-0.5	-0.7	1.0	1.4	1.7
Breast cancer (self-reported)	0.9	1.0	3.7	1.9	0.5	0.2	-1.8	-1.1	-1.2	-0.5	0.3	-0.6	-0.2	-0.7	-1.0
Ever depressed for a whole week	0.9	1.1	3.1	-1.3	-0.5	-0.3	0.1	0.5	-0.8	-1.4	-0.3	-1.7	-1.5	-1.8	-0.8
Respiratory disease	0.8	1.7	4.2	0.9	-0.4	-1.7	0.8	1.1	1.4	1.1	1.2	1.5	1.2	1.4	2.1
Ever used hormone-replacement therapy (HRT)	0.8	1.0	6.6	-0.3	-0.4	-1.0	-0.3	2.6	0.9	0.2	0.4	-0.2	-1.2	-1.5	-0.0
Diabetes (father)	0.8	1.0	1.7	-1.3	1.1	1.3	-1.1	-0.6	-1.1	-1.2	-0.9	0.6	-0.3	0.9	-0.8
Trunk fat percentage	0.8	3.4	14.6	-1.0	1.9	1.4	-0.7	-3.1	-1.1	0.5	-1.3	0.5	1.9	3.8	1.5
Hair/balding pattern: Pattern 2	0.8	1.0	4.2	0.2	-0.7	-0.4	-0.2	0.2	1.2	0.9	0.6	0.1	1.9	2.1	1.0
Time employed in main current job	0.8	0.9	3.3	1.8	-0.3	-0.9	-0.6	0.4	0.8	1.3	1.4	-0.8	0.2	-0.8	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	3.1	0.5	1.4	1.1	-1.3	-1.8	-1.6	-1.5	-0.0	-1.4	0.4	0.3	-1.0
Prospective memory result	0.8	1.0	3.9	-1.4	-0.7	-0.1	0.4	0.5	1.0	2.0	0.1	-0.4	-0.1	0.8	1.8
Body fat percentage	0.8	3.1	10.4	-1.2	2.1	1.6	-0.4	-3.0	-1.3	0.2	-1.7	0.8	1.6	3.2	1.1
Medication: Ibuprofen	0.8	1.0	3.0	-1.2	-1.3	-1.1	1.3	0.8	1.0	-0.2	0.3	1.7	0.9	0.3	0.5
Leg fat percentage (left)	0.8	3.1	8.2	-1.1	2.6	2.5	-0.3	-2.9	-1.7	-0.5	-2.2	0.8	0.8	2.0	-0.3
Waist Hip Ratio (WHR)	0.7	3.0	11.8	-3.4	-0.0	1.4	1.1	0.6	-0.4	-0.7	-2.0	-3.4	-1.6	-0.7	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.7	0.0	0.8	0.8	0.0	-0.0	-0.9	-1.1	-1.0	-0.7	-1.3	-1.2	-1.3
Medication: Cholesterol lowering	0.7	1.1	3.6	0.1	1.9	1.2	-0.5	-0.6	-1.4	-0.1	-0.6	-0.3	-1.6	-1.6	-0.3
Leg fat percentage (right)	0.7	2.7	6.4	-1.7	2.1	2.2	0.0	-2.5	-1.5	-0.7	-2.1	1.3	0.9	2.1	-0.2
Emphysema/chronic bronchitis	0.7	0.8	2.3	-1.2	0.4	0.4	1.3	0.0	0.5	0.3	-1.3	0.1	0.7	1.5	1.2
Medication: Allopurinol	0.7	0.9	2.7	-0.7	0.1	0.3	-1.0	-0.0	-1.2	-1.6	-0.5	-0.6	-1.1	-1.1	-1.6
Number of self-reported non-cancer illnesses	0.7	1.2	4.4	-0.4	1.1	0.7	0.2	2.1	0.0	-0.0	-0.1	-0.3	-2.1	-1.9	-0.3
Ovarian Cancer	0.6	0.7	2.5	-0.9	0.7	-0.1	0.9	-0.8	0.0	0.7	-0.4	-0.7	0.7	1.4	1.6
Mean Putamen Volume	0.6	0.7	6.1	0.0	-0.1	-0.1	-0.3	-0.6	0.2	0.5	0.1	-2.5	1.1	0.5	0.7
Hair/balding pattern: Pattern 4	0.6	1.4	5.2	1.0	-0.3	-0.4	1.6	0.1	1.3	1.9	0.4	-0.1	0.4	1.3	2.3
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.5	1.4	0.3	-0.9	-1.0	-0.8	-0.7	-1.0	1.3	-1.6	0.2	-0.6	-0.4
Gout (self-reported)	0.6	0.8	2.7	0.7	-0.1	-0.4	-1.7	0.5	-0.6	-0.8	0.7	-1.2	-0.9	-0.6	-1.3
Wheeze or whistling in the chest in last year	0.6	1.1	4.1	0.5	2.0	1.3	-1.2	-0.8	-0.5	0.8	-0.4	-1.1	0.4	1.1	1.0
Medication: Seretide 50 evohaler	0.6	0.7	3.3	0.5	0.9	0.1	-0.9	-1.4	-0.8	0.1	-0.1	-0.6	0.5	1.8	0.6
Alcohol intake frequency.	0.6	1.5	3.4	-0.6	0.7	1.9	-0.5	-1.4	-1.6	-1.5	-1.1	-1.3	-1.0	-0.3	-1.5
Leg pain on walking	0.6	0.7	3.1	-0.6	0.6	0.3	-0.3	0.1	-0.8	-0.4	-1.2	1.0	-1.8	-1.0	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	4.1	-2.0	0.7	0.7	0.0	-0.7	-0.6	0.5	-0.1	-0.2	0.5	0.9	0.2
Miserableness	0.6	1.1	3.6	0.5	0.5	-0.0	-1.2	-1.3	-1.4	-1.9	0.5	-1.2	0.2	-0.6	-1.5
Wears glasses or contact lenses	0.6	0.7	2.0	-0.4	-0.7	-0.3	1.3	1.4	0.9	1.0	0.0	-0.2	-0.8	-1.2	-0.0
Hearing aid user	0.6	0.6	2.0	0.9	-1.0	-0.3	-0.7	0.5	-0.1	-1.3	0.8	0.1	0.6	-0.2	-1.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	0.2	-0.8	-0.2	-1.2	-0.7	-0.2	-0.5	1.0	-1.1	1.2	0.6	-1.2
Average weekly beer plus cider intake	0.6	0.9	5.3	0.6	0.6	0.4	-1.8	-0.2	-0.2	-0.4	0.4	-2.3	0.6	0.8	0.0
Ever had prostate specific antigen (PSA) test	0.6	0.7	3.5	1.9	-0.1	-0.5	-0.4	0.2	0.1	0.5	1.6	0.7	0.2	-1.1	-0.1
Myopia	0.6	0.8	3.2	-0.3	-0.2	-1.0	0.8	0.1	0.7	1.8	0.5	0.2	0.0	-0.8	1.8
Basal cell carcinoma (self-reported)	0.6	0.7	3.2	0.8	-0.6	-0.1	-0.2	1.2	1.1	0.6	0.4	-1.8	0.3	0.6	0.2
LDL Cholesterol	0.5	0.8	2.3	0.2	-0.8	-0.6	1.3	1.5	1.4	0.8	0.3	1.2	-0.1	-0.0	0.9
Triglycerides	0.5	0.8	2.8	0.8	0.4	-0.2	-1.7	0.7	-0.6	-0.5	0.5	-1.3	-1.3	-1.0	-0.8
Blood Eosinophil Count	0.5	4.1	22.2	-0.2	-1.4	-2.4	0.5	1.4	2.2	2.6	0.8	-4.7	-0.1	0.4	2.3
Hypothyroidism (self reported)	0.5	1.0	2.5	-0.3	1.0	1.3	-1.6	-0.6	-0.8	0.1	-1.6	-1.3	0.4	1.3	-0.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	3.1	0.1	0.0	-1.3	1.0	0.9	0.1	-0.6	0.1	-0.3	-1.3	-1.8	-0.1
Stomach or abdominal pain in last month	0.5	0.6	2.3	0.6	-0.4	-0.7	0.4	0.6	1.0	0.5	1.5	0.1	0.8	0.7	0.8
Noisy workplace	0.5	0.7	1.8	0.1	0.9	0.7	-1.1	-0.8	-1.2	-0.9	-0.7	-0.4	0.0	-0.6	-1.3
Headache pain in last month	0.5	0.9	3.4	1.7	-0.5	-0.7	-1.2	0.6	0.2	-1.0	1.8	0.8	0.8	-0.2	-0.2
Eye problems/disorders: None of the above	0.5	0.6	3.1	0.4	1.2	0.6	-0.1	-0.6	-0.1	0.5	-1.1	1.7	0.5	0.3	0.2
Mood swings	0.5	0.8	2.0	0.8	-0.3	-1.3	0.8	1.1	0.7	0.5	0.5	1.4	-0.9	-1.3	0.5
Asthma (self-reported)	0.5	0.9	3.2	-0.8	0.3	-0.8	1.2	0.8	0.6	0.5	0.5	1.8	0.6	0.6	1.8
Commuting to job workplace: Cycle	0.5	0.6	1.7	-0.6	0.1	-0.1	-0.3	0.1	-0.7	-1.0	-0.3	-0.6	-1.1	-1.3	-1.3
Depressed Affect (Nagel 2018)	0.4	0.8	2.3	-0.1	0.1	-0.9	1.1	1.2	-0.1	-0.4	0.2	1.4	-1.5	-1.4	0.0
Alzheimer’s Disease (in father)	0.4	0.5	0.9	0.2	0.9	0.7	-0.8	0.9	-0.2	-0.3	0.4	-0.1	-1.0	-0.9	-0.8
Fasting Glucose	0.4	0.4	2.4	0.1	0.5	0.5	0.2	-0.9	-0.1	1.0	-0.1	-1.6	-0.3	0.0	0.4
Tanning	0.4	4.3	17.9	0.1	0.9	1.2	-1.0	-4.2	-2.3	-2.9	-1.2	-0.6	2.6	1.4	-2.7
Taking other prescription medications	0.4	0.6	2.9	0.3	0.5	0.1	0.3	1.3	-0.0	0.1	-0.0	-0.9	-1.7	-1.0	-0.2
Qualifications: CSEs or equivalent	0.4	0.6	3.0	0.7	0.8	0.4	-1.7	-0.5	-0.4	-0.1	0.9	-1.2	0.2	-0.0	-0.5
Medication: Simvastatin	0.4	0.6	1.9	-0.4	1.4	1.1	-0.7	-0.5	-1.1	-0.3	-0.3	-0.3	-0.5	-0.9	-0.3
Asthma	0.4	0.8	3.1	-0.9	0.3	-0.4	1.1	0.6	0.5	0.4	0.4	1.8	0.6	0.6	1.5
Loud music exposure frequency	0.4	0.5	1.8	0.3	1.2	0.6	0.3	-0.4	-0.5	-0.8	-1.4	-0.6	-0.3	-0.1	-0.5
Medication: Omeprazole	0.4	0.5	2.7	-0.4	0.3	0.1	-0.1	1.1	0.2	-0.5	-0.7	-1.6	-0.7	-0.5	-0.2
Number of full sisters	0.4	0.5	1.9	-0.2	0.0	-0.0	-0.2	-1.0	-0.6	-0.7	0.2	0.1	1.4	1.3	-0.3
Number of operations (self-reported)	0.4	0.6	1.6	0.1	-1.2	-0.9	0.2	0.7	1.1	0.2	1.0	0.1	1.3	0.3	-0.0
Pain experienced in last month	0.4	0.6	2.0	0.4	-0.6	-0.7	0.7	-0.9	0.6	0.8	0.3	-0.5	1.4	1.2	0.4
Primary Biliary Cirrhosis	0.3	0.5	1.9	-1.4	-0.0	0.6	0.9	0.8	0.1	0.0	-1.0	-0.4	-0.7	0.1	0.6
Had other major operations	0.3	0.3	1.3	0.5	0.1	-0.3	-0.4	1.1	0.2	0.4	0.4	-0.4	-0.7	-1.0	-0.0
Pain all over the body in last month	0.3	0.3	1.5	0.1	-0.3	0.0	0.0	1.2	0.7	0.4	1.1	-0.1	-0.5	-0.2	0.4
Medication: Lansoprazole	0.3	0.4	1.2	-0.9	-0.2	-0.1	0.1	1.1	0.4	-0.0	0.6	-0.1	-0.8	-1.0	0.2
Number of children fathered	0.3	0.4	1.0	-0.2	0.8	0.4	0.1	-0.8	-0.6	-1.0	-0.8	0.2	0.2	-0.0	-0.9
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	0.3	-0.8	-0.5	0.6	-0.3	0.7	-0.0	0.7	-0.9	1.0	0.7	-0.3
Loneliness, isolation	0.3	0.4	2.2	0.1	0.3	-0.4	1.3	0.3	0.2	-0.0	-0.2	1.5	-0.7	-0.1	0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.4	1.1	0.9	-0.0	-1.2	-0.3	-0.4	-0.2	1.1	-1.1	-0.1	0.1	-0.0
Mother’s age at death	0.3	0.4	1.3	0.7	-1.0	-1.1	0.8	-0.2	0.5	0.7	-0.4	-0.3	0.3	0.3	0.5
Alcohol drinker status: Never	0.3	0.4	1.3	0.7	-0.5	-0.6	0.4	0.5	0.8	1.1	0.3	0.7	-0.3	-0.8	0.5
Age started oral contraceptive pill	0.3	0.4	1.6	0.1	-0.3	-0.2	0.3	0.1	0.2	1.3	-0.7	-1.2	-0.3	-0.6	0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.4	-0.3	0.2	0.2	0.2	1.2	0.5	-0.0	-0.5	-1.1	-0.6	-0.5	0.2
Alcohol drinker status: Previous	0.3	0.3	0.6	-0.2	-0.3	0.1	0.6	0.8	0.4	0.7	-0.3	-0.8	-0.7	-0.6	0.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.9	0.1	0.9	0.4	-0.7	-0.4	-0.4	-0.2	-0.4	0.3	0.5	0.0	-0.1
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	0.0	0.9	0.1	-0.8	0.0	-0.6	-0.7	0.4	-0.4	-0.1	-0.8	-0.7
Fed-up feelings	0.2	0.5	1.7	-0.2	0.3	-0.5	0.9	1.0	0.4	-0.0	0.3	1.3	-0.3	0.6	1.0
Medication: Levothyroxine sodium	0.2	0.3	1.0	0.7	0.1	-0.1	-0.7	0.6	-0.3	-0.5	-0.9	0.3	-0.4	-1.0	-0.5
Depression (self-reported)	0.2	0.2	0.9	0.1	0.3	0.2	-0.4	0.3	-0.2	-0.2	-0.4	0.6	-0.5	-0.6	-0.9
Health satisfaction	0.2	0.3	1.7	-1.3	0.4	-0.2	0.1	-0.4	-0.7	-0.3	-1.0	-0.1	-0.1	-0.1	0.2
Shortness of breath walking on level ground	0.2	0.2	0.7	0.3	-0.3	-0.2	0.2	0.4	0.4	0.8	0.6	0.9	-0.2	0.2	0.7
High cholesterol (Self-reported)	0.2	0.4	2.0	-0.2	0.4	0.4	-0.2	-0.2	-0.8	-0.3	-0.3	-1.4	-0.7	-1.0	-0.5
Hair Pigment	0.1	3.0	7.7	-2.3	-1.9	-2.0	2.8	2.4	1.9	1.5	0.3	0.8	-0.8	-0.4	1.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	1.3	0.3	0.0	0.2	-0.6	0.7	-0.1	0.1	-1.1	-0.7	-0.4	-0.3	-0.3
Guilty feelings	0.1	0.2	1.0	0.1	0.1	-0.1	0.9	0.4	0.4	0.2	0.1	1.0	0.0	-0.3	-0.1

Hub : Genes

NT5C2

Models

Trait associations