Hub : Genes

NT5C2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0670 0.0240 1.2e-05 0.036 0.032 0.028 0.031 0.037 2.6e-05 8.0e-05 1.9e-04 9.8e-05 2.2e-05
2 GTEx Adipose Subcutaneous 0.0880 0.0400 2.4e-03 0.052 NA 0.023 NA 0.035 4.4e-05 NA 5.5e-03 NA 6.5e-04
3 GTEx Adipose Visceral Omentum 0.1290 0.0460 5.7e-05 0.072 NA 0.082 NA 0.063 1.4e-04 NA 5.0e-05 NA 3.5e-04
4 GTEx Artery Aorta 0.0760 0.0350 1.2e-03 0.016 NA -0.003 NA 0.007 4.1e-02 NA 5.5e-01 NA 1.2e-01
5 GTEx Artery Tibial 0.0611 0.0311 1.8e-03 0.040 NA 0.004 NA 0.017 4.4e-04 NA 1.4e-01 NA 1.5e-02
6 GTEx Brain Cerebellar Hemisphere 0.1480 0.0730 3.9e-03 0.103 NA 0.065 NA 0.057 1.4e-03 NA 9.2e-03 NA 1.4e-02
7 GTEx Brain Cerebellum 0.2340 0.1080 4.5e-04 0.154 NA 0.001 NA 0.088 2.6e-05 NA 3.0e-01 NA 1.4e-03
8 GTEx Brain Cortex 0.1960 0.0870 8.2e-03 0.036 NA 0.050 NA 0.000 3.7e-02 NA 1.7e-02 NA 3.3e-01
9 GTEx Pituitary 0.1890 0.0860 9.3e-03 -0.012 NA -0.003 NA 0.010 9.9e-01 NA 4.0e-01 NA 1.8e-01
10 GTEx Testis 0.2020 0.0630 1.2e-04 0.030 NA 0.073 NA 0.077 1.7e-02 NA 3.8e-04 NA 2.8e-04
11 YFS Blood 0.1327 0.0300 0.0e+00 0.098 0.112 0.111 0.113 0.108 2.0e-30 1.5e-34 1.9e-34 7.3e-35 2.3e-33
12 TCGA Prostate Adenocarcinoma 0.1445 0.0602 2.7e-13 0.129 0.113 0.115 NA 0.116 2.0e-13 8.0e-12 4.5e-12 NA 4.4e-12

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 1.6 2.5 10.3 0.0 -0.6 -0.4 0.4 3.0 0.8 0.4 0.1 -1.3 -3.2 -2.7 -0.4
Bipolar Disorder or Schizophrenia 6.8 16.7 50.5 -3.4 -3.0 -1.9 5.3 7.1 3.2 2.6 -1.5 0.6 -6.1 -6.2 1.5
Depressed Affect (Nagel 2018) 0.4 0.8 2.3 -0.1 0.1 -0.9 1.1 1.2 -0.1 -0.4 0.2 1.4 -1.5 -1.4 0.0
Depression (Nagel 2018) 1.3 2.0 8.1 -0.8 0.5 -0.6 1.2 1.5 -0.6 -0.9 -0.9 0.8 -2.8 -2.8 -0.4
Intelligence (Savage-Jansen 2018) 0.9 2.8 11.4 3.4 -0.8 -1.3 -0.7 -1.4 -0.1 0.5 3.3 -2.1 1.1 0.4 -0.2
Neuroticism (Nagel 2018) 3.2 7.5 18.1 -3.0 -0.8 -1.8 4.3 4.1 1.3 0.9 -1.2 2.7 -3.8 -3.9 1.4
Schizophrenia (2018) 8.8 18.2 44.8 -4.4 -3.4 -2.1 6.4 6.7 3.4 3.0 -2.4 1.9 -5.3 -5.8 2.2
Schizophrenia vs Biploar Disorder 4.6 6.1 13.7 -3.7 -0.3 0.3 3.1 2.9 0.6 1.1 -3.3 2.6 -3.3 -3.2 1.0
Worry (Nagel 2018) 8.5 17.9 45.0 -3.6 -2.8 -3.4 6.7 6.3 3.2 2.4 -0.9 4.2 -4.8 -5.8 2.6
Alzheimer’s Disease (in mother) 0.2 0.2 0.9 0.1 0.9 0.4 -0.7 -0.4 -0.4 -0.2 -0.4 0.3 0.5 0.0 -0.1
Alzheimer’s Disease (in father) 0.4 0.5 0.9 0.2 0.9 0.7 -0.8 0.9 -0.2 -0.3 0.4 -0.1 -1.0 -0.9 -0.8
Alzheimer’s Disease (including proxy) 0.2 0.3 0.8 0.0 0.9 0.1 -0.8 0.0 -0.6 -0.7 0.4 -0.4 -0.1 -0.8 -0.7
Crohns Disease (2017) 1.5 3.3 11.1 -1.6 2.1 3.3 -0.8 -0.7 -2.0 -1.3 -2.1 -2.0 -1.8 -0.5 -1.8
Irritable Bowel Disease (IBD) 1.5 3.5 15.5 0.8 1.5 2.2 -2.0 -0.1 -1.8 -1.7 -0.7 -3.9 -1.8 -1.2 -2.1
Ulcerative Colitis (UC) 2.0 3.7 15.4 3.0 0.6 0.8 -2.8 -0.3 -1.3 -1.6 1.0 -3.9 -0.9 -1.0 -2.0
Major Depression (MDD) 3.5 4.3 18.1 -1.9 0.8 0.8 1.6 2.4 -0.4 -0.7 -1.7 -1.1 -4.3 -3.7 -1.1
Reaction Time 2.1 4.0 11.1 -1.0 -0.1 -0.9 2.1 3.0 1.6 2.1 -1.3 3.3 -2.1 -1.6 2.3
Verbal and Numeric Reasoning (VNR) 1.2 2.8 11.5 3.4 -0.6 -1.3 -1.0 -2.5 -0.8 -0.4 2.6 -1.2 1.7 0.9 -0.4
Breast Cancer 1.1 2.7 6.9 -0.0 -1.7 -1.6 1.9 1.2 2.4 2.6 1.1 0.5 1.0 0.6 2.5
Ovarian Cancer 0.6 0.7 2.5 -0.9 0.7 -0.1 0.9 -0.8 0.0 0.7 -0.4 -0.7 0.7 1.4 1.6
Prostate Cancer 4.3 6.1 23.5 -0.0 -2.3 -2.4 3.1 2.6 3.2 2.1 1.3 4.8 0.8 0.4 2.1
Age at First Birth 3.2 4.6 15.6 3.4 -1.8 -2.1 -0.7 -0.9 1.4 2.0 3.9 -0.9 2.7 1.7 1.5
Bipolar Disorder (2011) 2.5 2.4 8.0 -0.3 -0.1 -0.3 0.6 2.3 0.2 -0.7 -1.7 -1.6 -2.8 -2.8 -1.1
Body Mass Index (BMI) (2010) 2.9 4.0 16.2 -0.8 1.7 2.3 -1.2 -3.3 -1.5 -0.4 -0.8 1.1 2.5 4.0 0.4
Coronary Artery Disease (CAD) 5.4 6.4 17.0 -2.8 -0.3 0.4 3.3 4.0 0.7 0.7 -3.2 0.7 -4.1 -3.6 0.4
Crohns Disease (2012) 2.3 3.7 7.1 -2.7 2.0 2.6 -0.2 -1.7 -2.5 -1.9 -2.4 -2.2 -1.2 0.0 -1.2
Mean Putamen Volume 0.6 0.7 6.1 0.0 -0.1 -0.1 -0.3 -0.6 0.2 0.5 0.1 -2.5 1.1 0.5 0.7
Fasting Glucose 0.4 0.4 2.4 0.1 0.5 0.5 0.2 -0.9 -0.1 1.0 -0.1 -1.6 -0.3 0.0 0.4
HbA1C 0.9 1.0 3.3 -0.8 -0.5 -0.0 1.1 1.8 1.0 1.5 0.3 0.7 -1.3 -0.4 0.9
HDL Cholesterol 1.3 2.1 8.0 -0.6 -2.3 -1.9 2.8 1.3 1.7 0.9 -0.0 1.2 0.0 -0.5 1.2
LDL Cholesterol 0.5 0.8 2.3 0.2 -0.8 -0.6 1.3 1.5 1.4 0.8 0.3 1.2 -0.1 -0.0 0.9
Lupus 1.4 2.2 6.6 2.2 0.2 -0.2 -2.6 -1.8 -1.4 -1.8 0.8 -1.2 1.1 0.4 -1.6
Neuroticism (2016) 1.5 2.2 8.7 -0.3 1.1 0.3 1.1 2.3 0.1 0.9 -0.1 1.7 -3.0 -2.5 0.3
Primary Biliary Cirrhosis 0.3 0.5 1.9 -1.4 -0.0 0.6 0.9 0.8 0.1 0.0 -1.0 -0.4 -0.7 0.1 0.6
Rheumatoid Arthritis 1.5 2.1 4.2 0.3 1.6 1.3 -2.0 -1.8 -2.1 -1.7 -1.3 -0.8 -0.8 -0.2 -2.0
Schizophrenia (2014) 7.3 16.1 44.0 -4.1 -2.6 -1.6 5.2 6.6 2.7 2.5 -2.5 1.3 -5.8 -6.2 1.7
Triglycerides 0.5 0.8 2.8 0.8 0.4 -0.2 -1.7 0.7 -0.6 -0.5 0.5 -1.3 -1.3 -1.0 -0.8
Type 2 Diabetes (T2D) (2012) 1.9 2.2 6.3 -1.7 -2.5 -2.1 1.3 1.7 1.2 0.8 -0.2 -1.4 0.1 0.6 2.0
Ulcerative Colitis 3.3 4.9 24.7 1.7 0.6 0.8 -2.7 -1.1 -2.3 -2.2 0.1 -5.0 -1.2 -1.7 -2.6
Blood Eosinophil Count 0.5 4.1 22.2 -0.2 -1.4 -2.4 0.5 1.4 2.2 2.6 0.8 -4.7 -0.1 0.4 2.3
Blood Platelet Count 1.8 21.4 69.7 -0.4 4.7 3.8 -7.0 -4.1 -5.7 -4.7 -3.3 -8.3 -0.4 0.4 -4.3
Blood Red Count 1.8 16.9 62.7 3.1 -0.5 -0.7 -3.8 2.5 -2.6 -4.0 2.0 -4.0 -5.3 -7.9 -6.2
Blood White Count 4.0 29.5 53.0 -3.1 5.9 5.6 -4.5 -4.0 -7.3 -6.2 -6.0 -6.0 -4.6 -4.5 -6.2
Heel T-Score 1.9 15.5 30.5 2.5 -5.0 -3.2 0.5 1.4 4.8 3.2 5.2 -3.7 5.4 5.5 2.8
BMI 1.7 10.1 39.3 0.5 2.8 2.6 -1.3 -5.6 -1.2 0.2 -0.7 1.9 5.2 6.3 1.4
Height 2.6 49.9 231.0 2.8 0.8 3.8 -9.0 -9.5 -6.5 -6.8 2.1 -15.2 2.5 4.5 -7.3
Waist Hip Ratio (WHR) 0.7 3.0 11.8 -3.4 -0.0 1.4 1.1 0.6 -0.4 -0.7 -2.0 -3.4 -1.6 -0.7 -1.0
Systolic Blood Pressure 9.4 47.2 213.2 -7.4 1.1 0.3 4.7 7.8 -1.8 -2.8 -5.1 0.8 -12.9 -14.6 -3.3
Smoking Status 18.9 45.2 85.2 -0.0 8.8 9.0 -7.1 -8.8 -9.2 -8.2 -4.9 -3.7 -0.4 0.9 -8.1
Allergy or Eczema 4.1 10.8 41.0 2.2 -2.3 -4.0 1.7 2.8 3.7 3.0 3.0 6.4 2.3 0.8 3.7
Cardiovascular Disease 5.0 16.7 73.4 -2.7 2.7 1.6 -0.1 1.5 -3.5 -2.8 -3.3 -3.7 -7.3 -8.6 -3.1
Hypothyroidism (self reported) 0.5 1.0 2.5 -0.3 1.0 1.3 -1.6 -0.6 -0.8 0.1 -1.6 -1.3 0.4 1.3 -0.1
Respiratory disease 0.8 1.7 4.2 0.9 -0.4 -1.7 0.8 1.1 1.4 1.1 1.2 1.5 1.2 1.4 2.1
Type 2 Diabetes (T2D) (2018) 2.0 3.7 11.1 -2.1 2.1 3.2 -0.0 -3.3 -1.0 1.0 -1.7 -1.3 0.9 2.5 0.9
Lung FEV1/FVC ratio 1.4 7.1 11.2 -0.3 2.4 3.2 -3.4 -3.0 -3.0 -3.3 -2.4 2.3 1.2 2.8 -2.9
Lung FVC 1.4 7.0 16.8 -2.9 1.5 2.5 1.0 1.5 -1.3 -1.8 -3.3 3.2 -4.0 -4.1 -2.1
Neuroticism 4.1 9.8 26.2 -2.9 -1.3 -2.2 4.8 4.3 1.4 0.5 -1.2 3.7 -4.2 -5.1 0.8
Chronotype (morning person) 1.6 3.6 22.4 4.7 0.2 -0.7 -1.6 -1.7 -0.7 -1.5 2.6 -0.2 0.8 -0.6 -2.1
Hair Pigment 0.1 3.0 7.7 -2.3 -1.9 -2.0 2.8 2.4 1.9 1.5 0.3 0.8 -0.8 -0.4 1.6
Tanning 0.4 4.3 17.9 0.1 0.9 1.2 -1.0 -4.2 -2.3 -2.9 -1.2 -0.6 2.6 1.4 -2.7
Hand grip strength (left) 3.7 9.7 20.9 0.7 2.2 3.4 -3.8 -4.6 -3.6 -4.2 -0.2 -3.6 1.2 1.8 -4.0
Number of treatments/medications taken 1.9 3.5 10.3 -1.4 1.6 2.0 -0.7 2.0 -1.3 -1.7 -1.2 -0.7 -3.2 -2.5 -2.4
Average weekly spirits intake 1.9 2.3 10.5 -3.2 1.1 1.7 1.3 -0.4 -0.4 -1.0 -2.5 0.6 0.6 1.8 0.4
Sensitivity / hurt feelings 1.8 3.0 8.6 -2.9 -0.8 -0.9 2.6 2.5 1.0 1.1 -0.8 1.5 -1.9 -1.8 1.2
Frequency of depressed mood in last 2 weeks 0.5 0.7 3.1 0.1 0.0 -1.3 1.0 0.9 0.1 -0.6 0.1 -0.3 -1.3 -1.8 -0.1
Hearing difficulty/problems: Yes 2.1 3.2 6.5 1.0 1.3 1.4 -2.2 -1.1 -2.2 -2.1 -0.8 -2.5 -1.4 -1.8 -2.6
Relative age of first facial hair 2.0 4.1 9.8 -1.5 1.9 1.3 -2.9 -2.3 -3.1 -2.7 -1.9 -1.7 0.2 1.0 -1.7
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 5.5 0.1 0.3 -0.8 -0.7 1.0 -0.6 -0.9 -0.6 -0.5 -1.8 -2.3 -1.0
Ever used hormone-replacement therapy (HRT) 0.8 1.0 6.6 -0.3 -0.4 -1.0 -0.3 2.6 0.9 0.2 0.4 -0.2 -1.2 -1.5 -0.0
Ever had hysterectomy (womb removed) 1.3 1.5 4.0 1.3 -1.8 -1.4 0.5 1.6 1.6 0.8 2.0 1.1 0.4 -0.1 0.3
Systolic blood pressure, automated reading 9.4 27.3 94.5 -6.6 1.9 1.9 4.5 5.2 -1.6 -1.9 -5.3 2.1 -9.7 -9.6 -1.9
Eye problems/disorders: Diabetes related eye disease 2.3 2.5 6.7 -0.7 1.6 1.6 -1.6 -1.8 -1.9 -2.0 -1.3 -2.6 0.1 -0.2 -1.7
Angina 2.6 3.4 7.9 -1.9 1.7 2.1 0.6 0.6 -1.5 -1.4 -2.5 -0.9 -2.7 -2.8 -1.7
Medication for hormone replacement therapy 0.9 1.0 3.8 0.1 0.2 -0.4 -1.9 0.4 -0.6 -1.9 0.6 -1.5 0.5 0.4 -1.3
Vitamin and mineral supplements 3.0 4.1 11.4 0.4 -2.4 -3.4 1.9 2.1 2.3 2.4 1.7 0.4 0.0 -0.2 3.1
Supplements: Zinc 2.7 2.9 5.7 -0.3 2.0 2.2 -1.8 -2.2 -2.4 -2.3 -1.2 -0.4 -0.1 0.0 -2.2
Medication: Co-codamol 1.1 1.3 4.2 -1.7 0.6 0.6 1.2 0.7 -0.8 -1.2 -1.2 0.9 -2.0 -1.2 -0.3
Medication: Metformin 1.0 1.4 5.4 -0.3 1.2 1.6 -0.5 -2.3 -0.4 0.5 -0.6 -0.6 1.6 1.9 0.2
Diabetes (father) 0.8 1.0 1.7 -1.3 1.1 1.3 -1.1 -0.6 -1.1 -1.2 -0.9 0.6 -0.3 0.9 -0.8
Diabetes (mother) 1.2 1.5 5.5 -1.0 0.1 0.7 -1.0 -1.4 -0.6 -0.5 -0.7 -2.4 1.8 1.8 -0.4
Severe depression (siblings) 1.8 2.0 5.2 -2.3 0.6 0.4 -0.1 1.4 -0.7 -0.9 -1.9 0.9 -2.3 -2.1 -1.1
Pack years adult smoking proportion 2.4 3.7 8.7 -1.5 2.2 1.7 -0.9 -2.8 -2.9 -2.7 -2.4 -0.0 -0.7 0.4 -1.7
Impedance of leg (right) 2.2 10.5 40.0 -3.4 -2.1 -2.0 2.9 4.3 0.3 -1.5 -1.4 -0.6 -5.6 -6.3 -1.6
Leg fat-free mass (left) 3.5 18.3 56.2 2.5 2.7 3.2 -5.5 -7.5 -3.3 -1.9 0.7 -4.4 5.2 6.9 -1.2
Trunk fat percentage 0.8 3.4 14.6 -1.0 1.9 1.4 -0.7 -3.1 -1.1 0.5 -1.3 0.5 1.9 3.8 1.5
Hand grip strength (right) 2.6 7.0 15.9 -0.2 2.2 3.5 -2.6 -4.0 -3.2 -3.7 -1.2 -2.0 0.9 2.0 -3.2
Townsend deprivation index at recruitment 3.2 4.5 10.6 0.1 2.3 2.0 -2.8 -3.2 -2.8 -2.6 -1.0 -1.8 0.9 1.5 -2.1
Current tobacco smoking 8.4 13.8 27.8 -0.9 4.9 5.3 -3.8 -5.1 -5.2 -4.3 -3.2 -1.2 -0.3 1.1 -3.8
Average weekly fortified wine intake 2.3 2.7 6.4 0.3 -2.0 -1.7 1.5 1.8 2.5 2.0 1.2 -0.1 1.6 1.1 2.1
Maternal smoking around birth 8.5 12.2 25.2 -0.8 5.0 4.8 -3.4 -4.5 -4.7 -4.2 -2.4 -2.6 -0.2 0.5 -3.8
Fed-up feelings 0.2 0.5 1.7 -0.2 0.3 -0.5 0.9 1.0 0.4 -0.0 0.3 1.3 -0.3 0.6 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 2.8 -0.0 1.5 0.8 -0.4 -0.7 -1.6 -1.7 -0.8 0.5 -1.2 -1.0 -1.4
Relative age voice broke 1.3 1.9 4.8 -1.8 1.1 1.3 -0.7 -0.5 -1.8 -2.2 -1.9 -0.7 -1.4 -0.3 -1.5
Taking other prescription medications 0.4 0.6 2.9 0.3 0.5 0.1 0.3 1.3 -0.0 0.1 -0.0 -0.9 -1.7 -1.0 -0.2
Age when periods started (menarche) 1.6 3.7 9.2 1.1 2.3 1.7 -3.0 -2.5 -1.7 -0.9 -0.5 -2.1 1.7 2.9 -0.8
Bilateral oophorectomy (both ovaries removed) 1.8 2.1 8.5 0.4 -0.1 -0.1 0.9 2.9 0.9 0.7 -0.3 1.0 -2.7 -2.4 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.3 9.0 -0.4 -3.0 -1.5 1.4 1.3 2.6 1.6 1.7 -1.8 1.6 2.0 1.6
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 4.8 -0.5 1.6 2.2 -1.1 -0.7 -1.9 -1.7 -1.4 0.7 -0.2 -0.5 -1.8
Qualifications: CSEs or equivalent 0.4 0.6 3.0 0.7 0.8 0.4 -1.7 -0.5 -0.4 -0.1 0.9 -1.2 0.2 -0.0 -0.5
Serious illness, injury or assault to yourself 2.0 2.4 8.8 -3.0 0.8 0.5 1.1 0.7 -0.7 -0.8 -2.1 1.7 -2.4 -1.8 -0.4
High blood pressure 6.0 16.6 59.4 -3.2 3.3 2.7 -0.1 1.3 -3.8 -2.9 -3.8 -2.4 -7.5 -7.7 -3.5
Hayfever, allergic rhinitis or eczema 3.6 7.9 26.3 1.7 -2.4 -3.9 1.8 2.1 3.0 2.3 2.9 5.1 2.0 0.2 3.0
Multivitamins +/- minerals 1.1 1.3 4.3 0.2 1.0 1.4 -1.5 -1.2 -1.2 -1.5 -1.0 -0.5 0.4 -0.2 -2.1
Stomach or abdominal pain in last month 0.5 0.6 2.3 0.6 -0.4 -0.7 0.4 0.6 1.0 0.5 1.5 0.1 0.8 0.7 0.8
Supplements: Glucosamine 2.1 2.7 8.4 -0.5 2.4 2.9 -0.8 -1.2 -2.0 -1.9 -1.8 -0.8 -0.7 -0.5 -1.9
Diverticular disease/diverticulitis (self-reported) 1.9 2.3 6.3 -0.3 -1.7 -0.9 2.5 2.0 2.0 1.4 0.7 1.4 0.6 0.2 2.1
Medication: Atenolol 2.0 2.5 7.0 -1.2 1.4 1.1 0.1 -0.6 -1.5 -0.7 -2.4 -1.1 -2.6 -2.6 -1.0
Medication: Levothyroxine sodium 0.2 0.3 1.0 0.7 0.1 -0.1 -0.7 0.6 -0.3 -0.5 -0.9 0.3 -0.4 -1.0 -0.5
Sitting height 2.3 16.3 96.8 1.4 0.9 1.7 -4.7 -3.8 -4.0 -3.6 -0.1 -9.8 -2.1 -1.7 -4.5
Chronic bronchitis/emphysema (father) 0.9 1.0 5.1 -2.3 -0.1 0.6 1.0 1.5 0.7 0.9 -0.4 0.5 -1.0 0.3 0.8
High blood pressure (mother) 3.4 4.7 24.5 -1.8 0.4 0.0 1.4 1.9 -0.6 -0.0 -1.8 1.5 -4.1 -4.9 -0.7
Body mass index (BMI) 1.4 5.8 20.7 0.0 2.9 2.5 -1.5 -4.0 -1.6 0.0 -1.2 1.5 3.1 4.5 0.8
Impedance of leg (left) 2.0 9.9 42.8 -2.7 -1.4 -1.6 2.5 3.7 -0.2 -1.5 -1.7 -1.1 -5.8 -6.5 -1.9
Leg predicted mass (left) 3.4 18.0 55.6 2.4 2.7 3.2 -5.4 -7.5 -3.4 -1.9 0.6 -4.4 5.1 6.7 -1.3
Trunk fat mass 1.6 7.0 24.8 -0.1 2.5 2.5 -2.4 -4.9 -2.2 -0.6 -1.0 -1.5 2.9 5.0 0.3
Waist circumference 1.9 7.1 20.7 -1.0 2.8 3.3 -2.6 -4.5 -2.9 -1.6 -1.9 -2.1 1.9 3.7 -1.2
Number of incorrect matches in round 4.6 7.7 19.4 -1.2 -3.3 -3.4 3.3 4.4 3.6 2.7 1.2 2.4 -0.9 -1.5 2.7
Past tobacco smoking 15.3 28.1 52.3 1.2 -7.1 -7.2 5.1 6.4 7.2 5.9 5.1 3.9 1.5 -0.1 6.1
Alcohol usually taken with meals 4.0 6.4 13.8 0.0 -3.5 -3.5 3.7 2.1 3.3 2.9 1.9 2.2 0.8 -0.0 2.6
Nervous feelings 6.9 12.9 33.0 -3.4 -3.0 -3.1 5.7 5.5 3.1 2.3 -0.2 3.0 -3.5 -4.3 2.7
Frequency of tenseness / restlessness in last 2 weeks 2.5 3.8 20.1 -0.9 0.8 -0.5 1.2 1.3 -1.0 -1.5 -1.4 1.8 -3.3 -4.5 -1.3
Hearing difficulty/problems with background noise 3.4 5.5 13.6 0.9 1.2 1.2 -2.8 -2.7 -3.3 -3.1 -0.9 -2.9 -1.3 -1.4 -3.7
Hair/balding pattern: Pattern 2 0.8 1.0 4.2 0.2 -0.7 -0.4 -0.2 0.2 1.2 0.9 0.6 0.1 1.9 2.1 1.0
Had menopause 1.4 1.8 7.2 -0.2 -0.7 -0.6 1.5 2.7 1.0 0.6 -0.5 1.7 -1.6 -2.1 -0.0
Had other major operations 0.3 0.3 1.3 0.5 0.1 -0.3 -0.4 1.1 0.2 0.4 0.4 -0.4 -0.7 -1.0 -0.0
Forced vital capacity (FVC) 2.5 9.7 22.1 -1.1 1.9 3.2 -3.0 -2.7 -3.9 -4.3 -2.5 -3.6 -2.5 -1.9 -4.7
Heel bone mineral density (BMD) T-score, automated (right) 2.0 4.5 12.6 0.2 -3.5 -1.9 0.7 1.2 2.7 1.3 2.8 -2.4 2.4 2.5 1.3
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 4.6 -0.5 0.9 1.0 -1.0 -0.8 -1.9 -2.1 -1.0 -0.6 -1.3 -1.7 -2.1
Qualifications: None of the above 1.8 3.9 8.4 -1.1 2.7 2.9 -1.5 -1.6 -2.7 -2.0 -2.6 0.1 -1.7 -0.7 -1.9
Financial difficulties in last 2 years 2.3 3.0 11.2 -1.1 1.4 1.5 -1.5 -2.0 -2.7 -3.3 -0.9 0.3 -1.0 -0.2 -2.1
Mouth/teeth dental problems 3.4 5.2 13.5 -0.6 -3.0 -2.6 3.7 2.4 3.1 2.2 1.2 2.1 0.6 -0.3 2.4
Heart attack 3.5 4.5 15.8 -2.6 2.0 2.3 0.6 1.6 -1.0 -0.5 -3.4 -0.1 -4.0 -2.5 -0.4
Allergy 2.9 6.7 22.4 -0.0 1.8 3.0 -2.5 -2.6 -3.0 -2.1 -2.2 -4.7 -2.0 -0.8 -3.2
Pain all over the body in last month 0.3 0.3 1.5 0.1 -0.3 0.0 0.0 1.2 0.7 0.4 1.1 -0.1 -0.5 -0.2 0.4
Diabetes (self-reported) 1.3 2.0 7.6 -1.5 1.1 1.8 -0.3 -2.8 -0.6 0.8 -0.9 -1.2 1.1 2.1 0.9
Hayfever/allergic rhinitis (self-reported) 1.9 2.5 8.2 1.1 -1.6 -2.5 0.2 1.1 1.4 1.4 2.9 1.4 1.4 0.3 1.6
Medication: Ramipril 2.4 3.1 11.4 -1.8 -0.1 0.1 1.1 3.2 0.7 1.0 -0.6 0.3 -3.4 -3.1 -0.3
Medication: Simvastatin 0.4 0.6 1.9 -0.4 1.4 1.1 -0.7 -0.5 -1.1 -0.3 -0.3 -0.3 -0.5 -0.9 -0.3
Fluid intelligence score 1.5 3.1 9.6 2.6 -1.6 -1.8 -0.1 -2.0 0.1 -0.4 2.6 -1.0 3.1 1.6 0.1
Illnesses of siblings 3.1 4.4 9.2 1.4 -2.3 -3.0 1.6 0.0 2.5 2.0 1.9 1.5 2.6 2.2 2.3
Neuroticism score 2.5 5.2 13.7 -1.5 -0.7 -1.5 3.7 3.3 1.1 0.4 -0.6 3.0 -3.2 -3.4 0.8
Weight 2.9 14.1 48.0 1.1 3.1 3.5 -4.5 -6.9 -3.8 -2.4 -0.7 -3.6 3.6 5.4 -1.8
Impedance of arm (right) 0.9 4.4 11.5 -1.1 -2.0 -3.3 2.2 3.4 1.9 1.5 -0.2 0.7 -2.3 -1.8 2.4
Arm fat percentage (right) 1.0 4.1 17.9 -0.5 2.2 1.3 -0.6 -3.1 -0.7 0.8 -1.1 1.5 2.5 4.2 2.0
Trunk fat-free mass 3.6 20.6 53.7 2.5 2.5 4.0 -6.2 -7.3 -4.5 -3.9 0.5 -6.6 3.4 4.4 -4.1
Hip circumference 2.4 10.2 36.3 1.0 2.9 2.9 -3.9 -6.0 -3.2 -1.8 -1.0 -1.7 3.4 4.8 -1.1
Time employed in main current job 0.8 0.9 3.3 1.8 -0.3 -0.9 -0.6 0.4 0.8 1.3 1.4 -0.8 0.2 -0.8 0.8
Alcohol intake versus 10 years previously 5.0 7.4 17.5 -0.9 3.5 4.2 -2.8 -2.5 -3.7 -3.5 -2.4 -0.8 -1.0 0.4 -3.3
Father’s age at death 1.1 1.5 6.3 0.1 -1.7 -1.2 2.5 0.5 1.5 1.1 0.9 0.8 0.4 0.9 0.9
Worrier / anxious feelings 8.5 16.1 43.6 -1.4 -3.7 -4.5 5.3 6.6 4.3 3.2 1.4 3.7 -3.3 -4.5 3.2
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.4 3.1 0.5 1.4 1.1 -1.3 -1.8 -1.6 -1.5 -0.0 -1.4 0.4 0.3 -1.0
Falls in the last year 3.7 5.0 11.9 -1.1 3.5 3.1 -1.1 -0.0 -2.5 -1.8 -2.5 -1.7 -3.3 -1.8 -1.6
Hair/balding pattern: Pattern 3 1.4 2.1 5.3 -0.2 1.3 1.4 -0.3 0.2 -1.2 -1.1 -1.1 -1.4 -2.2 -2.3 -2.2
Number of live births 1.5 2.2 5.6 -2.2 -0.4 0.1 2.4 2.3 1.0 0.9 -1.0 0.6 -1.7 -1.8 0.9
Forced expiratory volume in 1-second (FEV1) 2.2 7.5 18.2 -1.3 1.7 2.9 -3.0 -2.6 -3.5 -4.0 -2.3 -2.1 -1.9 -1.2 -4.3
Pulse rate 2.2 3.7 9.5 -1.1 -1.5 -1.8 3.1 2.6 2.0 2.1 -0.5 2.1 -0.8 -0.7 2.7
Happiness 1.0 1.2 3.0 -1.0 -0.8 -0.2 1.7 1.7 1.3 1.0 -0.2 1.7 0.0 0.7 1.1
Noisy workplace 0.5 0.7 1.8 0.1 0.9 0.7 -1.1 -0.8 -1.2 -0.9 -0.7 -0.4 0.0 -0.6 -1.3
Qualifications: A levels/AS levels or equivalent 1.1 2.5 9.4 0.5 -2.4 -3.1 1.1 -0.2 1.2 1.1 2.0 -1.1 1.8 0.1 1.5
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.7 0.0 0.8 0.8 0.0 -0.0 -0.9 -1.1 -1.0 -0.7 -1.3 -1.2 -1.3
Mouth/teeth dental problems: Dentures 2.3 3.9 8.5 0.1 1.9 2.4 -2.7 -2.9 -2.6 -2.1 -0.6 -1.7 0.5 1.0 -2.4
Asthma 0.4 0.8 3.1 -0.9 0.3 -0.4 1.1 0.6 0.5 0.4 0.4 1.8 0.6 0.6 1.5
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 6.8 -1.5 -0.8 -0.8 1.4 1.4 1.3 0.2 -0.1 2.6 0.5 0.5 0.8
Medication: Cholesterol lowering 0.7 1.1 3.6 0.1 1.9 1.2 -0.5 -0.6 -1.4 -0.1 -0.6 -0.3 -1.6 -1.6 -0.3
Depression (self-reported) 0.2 0.2 0.9 0.1 0.3 0.2 -0.4 0.3 -0.2 -0.2 -0.4 0.6 -0.5 -0.6 -0.9
Medication: Lansoprazole 0.3 0.4 1.2 -0.9 -0.2 -0.1 0.1 1.1 0.4 -0.0 0.6 -0.1 -0.8 -1.0 0.2
Prospective memory result 0.8 1.0 3.9 -1.4 -0.7 -0.1 0.4 0.5 1.0 2.0 0.1 -0.4 -0.1 0.8 1.8
Lung cancer (father) 1.4 1.6 6.2 1.3 -1.0 -0.0 -0.4 -1.3 0.4 0.8 0.8 -1.7 2.5 1.9 0.4
Illnesses of mother 1.1 1.4 5.9 0.7 -0.6 0.0 -0.7 -0.6 0.8 0.5 1.9 -0.1 2.1 2.4 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.7 5.6 14.6 -0.6 1.5 2.5 -2.6 -2.0 -2.9 -3.8 -1.7 -1.7 -1.8 -1.0 -3.8
Pulse wave Arterial Stiffness index 3.0 3.5 14.8 -1.2 -1.1 -0.5 2.1 3.9 2.4 2.2 -0.1 1.0 -1.6 -1.9 1.5
Impedance of arm (left) 0.9 4.4 13.0 -1.1 -1.8 -3.0 2.0 3.6 1.7 1.4 -0.3 0.7 -2.6 -2.1 2.3
Arm fat mass (right) 1.4 5.7 21.6 0.2 2.3 2.0 -2.0 -4.4 -1.8 -0.2 -0.8 -0.4 3.0 4.6 0.8
Trunk predicted mass 3.6 20.4 53.9 2.6 2.5 4.0 -6.2 -7.3 -4.4 -3.8 0.5 -6.5 3.5 4.5 -4.1
Standing height 2.9 29.1 132.2 2.4 0.7 2.4 -7.1 -7.2 -5.2 -5.5 1.0 -11.5 1.9 2.7 -5.8
Length of working week for main job 1.0 1.2 5.7 -1.2 0.3 0.4 -0.7 -1.6 -1.2 -0.8 -0.6 -2.4 0.3 1.0 -0.2
Exposure to tobacco smoke at home 0.9 1.0 4.0 0.1 0.7 -0.2 -0.1 -2.0 -0.5 0.2 -0.2 0.8 1.5 2.0 0.8
Breastfed as a baby 1.5 1.8 4.3 0.5 -2.1 -1.7 0.9 2.0 1.3 1.2 0.9 0.6 -1.2 -2.0 -0.2
Tense / ‘highly strung’ 4.1 6.9 22.9 -2.2 2.3 1.6 1.7 0.9 -1.8 -1.3 -3.7 2.0 -4.8 -4.3 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.7 8.6 -2.8 0.2 -0.0 0.2 2.1 -0.8 -1.6 -1.2 -0.6 -2.3 -2.9 -1.0
Hair/balding pattern: Pattern 4 0.6 1.4 5.2 1.0 -0.3 -0.4 1.6 0.1 1.3 1.9 0.4 -0.1 0.4 1.3 2.3
Birth weight of first child 4.2 7.7 29.5 3.3 2.3 1.4 -4.1 -5.4 -2.9 -1.2 0.4 -2.5 2.2 2.1 -1.3
Peak expiratory flow (PEF) 3.4 8.0 19.1 -0.5 2.2 3.2 -3.0 -4.4 -3.5 -3.8 -2.1 -2.6 0.2 1.2 -3.6
Pulse wave reflection index 4.7 5.8 15.5 2.2 1.4 2.1 -3.9 -2.3 -1.9 -2.6 1.3 -2.6 2.2 1.4 -3.4
Ever highly irritable/argumentative for 2 days 1.5 1.7 5.6 -0.1 -0.6 -0.6 -0.5 0.7 -0.7 -2.2 0.7 -1.6 -1.4 -2.4 -1.9
Loud music exposure frequency 0.4 0.5 1.8 0.3 1.2 0.6 0.3 -0.4 -0.5 -0.8 -1.4 -0.6 -0.3 -0.1 -0.5
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.5 1.4 0.3 -0.9 -1.0 -0.8 -0.7 -1.0 1.3 -1.6 0.2 -0.6 -0.4
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 6.4 1.8 2.0 1.0 -2.5 -1.9 -1.8 -1.0 -0.5 -1.1 -0.3 0.7 -0.9
Blood clot in the leg (DVT) 1.7 2.2 5.5 -1.6 -1.4 -1.1 1.5 2.3 2.1 1.4 0.6 1.6 -0.0 0.4 1.7
Medication: Paracetamol 1.3 2.1 10.9 -2.7 -0.5 0.1 0.6 3.3 0.6 -1.1 -0.5 0.5 -1.7 -1.0 -0.5
Headache pain in last month 0.5 0.9 3.4 1.7 -0.5 -0.7 -1.2 0.6 0.2 -1.0 1.8 0.8 0.8 -0.2 -0.2
Medication for cholesterol, blood pressure or diabetes 1.5 2.6 10.1 0.3 -1.9 -1.4 0.4 -0.2 1.6 0.1 0.5 1.2 3.2 3.2 1.0
Glaucoma (self-reported) 1.3 1.6 5.0 -2.0 0.0 0.7 2.2 0.8 0.3 0.8 -1.2 1.8 -1.6 -0.7 0.5
Gout (self-reported) 0.6 0.8 2.7 0.7 -0.1 -0.4 -1.7 0.5 -0.6 -0.8 0.7 -1.2 -0.9 -0.6 -1.3
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 1.3 0.3 0.0 0.2 -0.6 0.7 -0.1 0.1 -1.1 -0.7 -0.4 -0.3 -0.3
Medication: Amlodipine 1.1 1.6 9.6 -0.3 0.4 -0.8 1.1 0.8 -0.5 -0.2 -0.4 0.9 -2.3 -3.1 0.3
Medication: Ventolin 100micrograms inhaler 1.5 1.9 5.7 -1.0 -1.2 -1.4 1.6 1.5 1.9 1.5 0.7 0.5 0.8 1.0 2.4
Birth weight 6.6 14.4 52.9 7.3 1.2 1.4 -6.1 -4.1 -1.7 -1.1 2.5 -4.7 3.3 4.0 -1.8
Chronic bronchitis/emphysema (mother) 0.9 1.0 5.0 0.8 0.7 0.5 -1.0 -1.0 -0.7 -1.1 0.1 -2.2 0.4 0.9 -1.1
High blood pressure (siblings) 2.6 3.7 10.9 -1.3 1.7 2.1 -0.7 1.2 -1.6 -1.3 -1.3 -1.4 -3.3 -3.3 -1.9
Forced vital capacity (FVC), Best measure 1.7 6.0 15.4 -0.5 1.2 2.4 -2.4 -1.9 -2.9 -3.9 -1.4 -2.9 -2.1 -1.4 -3.9
Body fat percentage 0.8 3.1 10.4 -1.2 2.1 1.6 -0.4 -3.0 -1.3 0.2 -1.7 0.8 1.6 3.2 1.1
Leg fat percentage (right) 0.7 2.7 6.4 -1.7 2.1 2.2 0.0 -2.5 -1.5 -0.7 -2.1 1.3 0.9 2.1 -0.2
Arm fat-free mass (right) 3.5 18.0 49.8 1.8 3.0 4.4 -5.6 -7.1 -4.5 -3.4 -0.3 -5.8 2.9 4.1 -3.7
Exposure to tobacco smoke outside home 4.7 6.2 17.4 -0.3 2.6 3.1 -2.2 -4.2 -3.2 -2.7 -2.0 -1.3 1.2 2.2 -2.6
Comparative body size at age 10 1.5 4.0 11.7 -1.9 1.5 2.4 2.0 -2.5 -0.3 0.7 -2.3 1.9 1.4 3.4 1.6
Number of full brothers 2.4 3.0 5.4 -0.4 2.2 1.9 -2.3 -0.9 -2.3 -2.0 -1.5 -0.6 -1.9 -1.4 -2.2
Worry too long after embarrassment 2.9 4.8 15.8 -3.6 -0.4 -0.6 4.0 2.1 0.9 0.6 -1.4 3.1 -2.3 -2.2 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.9 2.4 11.3 -1.0 -0.1 -0.6 0.9 2.4 -0.1 -0.6 -0.8 0.7 -2.9 -3.4 -0.6
Wheeze or whistling in the chest in last year 0.6 1.1 4.1 0.5 2.0 1.3 -1.2 -0.8 -0.5 0.8 -0.4 -1.1 0.4 1.1 1.0
Number of children fathered 0.3 0.4 1.0 -0.2 0.8 0.4 0.1 -0.8 -0.6 -1.0 -0.8 0.2 0.2 -0.0 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 5.1 -0.4 -0.4 -0.3 -1.6 0.1 -1.0 -1.3 0.5 -2.2 -0.5 -1.7 -1.7
Age at first live birth 2.0 3.6 12.0 2.6 -1.4 -1.5 0.8 -0.2 2.2 3.5 1.7 -0.1 2.0 1.8 2.1
Pulse wave peak to peak time 3.9 4.6 17.7 1.4 0.9 0.5 -2.6 -4.2 -2.5 -2.3 0.4 -1.9 2.0 2.3 -1.7
Health satisfaction 0.2 0.3 1.7 -1.3 0.4 -0.2 0.1 -0.4 -0.7 -0.3 -1.0 -0.1 -0.1 -0.1 0.2
Shortness of breath walking on level ground 0.2 0.2 0.7 0.3 -0.3 -0.2 0.2 0.4 0.4 0.8 0.6 0.9 -0.2 0.2 0.7
Qualifications: College or University degree 2.3 7.2 16.2 -1.2 -4.0 -3.5 3.9 2.6 3.4 2.9 1.5 1.4 1.0 -0.0 3.1
Eye problems/disorders: None of the above 0.5 0.6 3.1 0.4 1.2 0.6 -0.1 -0.6 -0.1 0.5 -1.1 1.7 0.5 0.3 0.2
Mouth/teeth dental problems: Loose teeth 1.2 1.4 3.9 -1.0 1.7 2.0 -1.2 -1.4 -1.0 0.2 -1.1 -0.7 0.2 1.7 0.2
Emphysema/chronic bronchitis 0.7 0.8 2.3 -1.2 0.4 0.4 1.3 0.0 0.5 0.3 -1.3 0.1 0.7 1.5 1.2
Medication for pain relief, constipation, heartburn 1.1 1.9 9.9 2.1 0.6 0.2 -1.0 -3.1 -1.1 0.1 0.2 -0.7 1.9 1.0 -0.3
Neck or shoulder pain in last month 2.3 3.3 9.4 -2.2 1.2 0.8 0.4 0.4 -1.6 -1.7 -2.8 0.9 -3.1 -2.7 -1.2
Medication: Blood pressure 1.8 3.1 13.8 -0.3 1.3 0.8 -0.7 0.9 -1.4 -0.4 -0.5 -1.6 -3.6 -3.7 -1.4
Angina (self-reported) 3.3 4.3 9.9 -2.4 1.8 2.3 0.8 0.9 -1.5 -1.3 -3.0 -0.7 -3.1 -3.1 -1.7
Migraine (self-reported) 4.7 5.8 19.8 3.6 -0.7 -0.3 -2.8 -2.5 -0.4 -1.5 2.9 -1.3 4.5 2.8 -1.2
Medication: Ibuprofen 0.8 1.0 3.0 -1.2 -1.3 -1.1 1.3 0.8 1.0 -0.2 0.3 1.7 0.9 0.3 0.5
Medication: Allopurinol 0.7 0.9 2.7 -0.7 0.1 0.3 -1.0 -0.0 -1.2 -1.6 -0.5 -0.6 -1.1 -1.1 -1.6
Medication: Omeprazole 0.4 0.5 2.7 -0.4 0.3 0.1 -0.1 1.1 0.2 -0.5 -0.7 -1.6 -0.7 -0.5 -0.2
Medication: Seretide 50 evohaler 0.6 0.7 3.3 0.5 0.9 0.1 -0.9 -1.4 -0.8 0.1 -0.1 -0.6 0.5 1.8 0.6
Mean time to correctly identify matches 1.4 2.7 6.4 -1.1 0.1 0.3 1.8 2.3 0.9 1.7 -1.8 2.1 -2.5 -1.6 1.2
Heart disease (mother) 2.0 2.4 7.8 -1.5 -0.7 -0.8 2.8 2.7 1.4 0.9 -0.7 0.9 -1.9 -0.9 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 3.8 -0.3 0.7 -0.0 -1.4 -1.9 -1.9 -1.4 0.0 0.1 -0.1 -0.1 -0.8
Whole body fat mass 1.7 7.1 24.5 -0.4 2.9 2.8 -2.3 -5.0 -2.5 -0.7 -1.5 -1.1 2.6 4.7 0.1
Leg fat mass (right) 1.9 7.2 25.9 -0.3 2.9 3.0 -2.3 -5.1 -2.8 -1.5 -1.5 -1.2 2.5 4.1 -0.8
Arm predicted mass (right) 3.6 18.3 51.4 1.9 3.0 4.2 -5.7 -7.2 -4.7 -3.5 -0.2 -5.7 2.9 4.0 -3.8
Pulse rate, automated reading 1.1 3.7 8.2 -0.5 -1.3 -2.7 2.4 2.9 1.0 1.1 -0.4 0.7 -2.4 -2.9 1.9
Alcohol intake frequency. 0.6 1.5 3.4 -0.6 0.7 1.9 -0.5 -1.4 -1.6 -1.5 -1.1 -1.3 -1.0 -0.3 -1.5
Comparative height size at age 10 1.9 10.7 48.0 1.7 -1.4 1.6 -3.6 -3.9 -1.4 -2.1 1.7 -6.9 3.3 3.9 -3.1
Number of full sisters 0.4 0.5 1.9 -0.2 0.0 -0.0 -0.2 -1.0 -0.6 -0.7 0.2 0.1 1.4 1.3 -0.3
Suffer from ‘nerves’ 3.3 5.2 13.4 -1.6 -1.5 -1.7 3.4 3.7 1.8 1.4 -0.1 1.3 -3.4 -3.3 1.1
Overall health rating 1.3 2.7 6.2 0.1 2.3 1.7 -1.2 -1.6 -2.5 -1.7 -2.1 0.7 -1.0 -1.5 -1.7
Chest pain or discomfort 1.9 2.8 5.6 0.4 2.2 1.7 -1.3 -0.3 -1.9 -2.4 -0.8 -0.6 -1.6 -2.4 -2.3
Had major operations 1.4 1.6 4.4 -1.3 1.0 1.4 -0.4 -1.6 -1.6 -2.1 -1.1 0.8 0.4 0.7 -1.6
Age at last live birth 0.9 1.4 6.7 1.1 0.5 0.2 0.5 -0.5 1.0 2.6 -0.5 -0.7 1.0 1.4 1.7
Family relationship satisfaction 1.9 2.3 6.6 -0.9 1.4 1.4 0.1 -1.1 -2.0 -1.8 -2.6 0.3 -1.9 -1.0 -1.8
Leg pain on walking 0.6 0.7 3.1 -0.6 0.6 0.3 -0.3 0.1 -0.8 -0.4 -1.2 1.0 -1.8 -1.0 -0.4
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.3 6.3 -1.3 2.5 2.2 -1.1 -1.2 -1.9 -0.7 -2.4 -0.5 -1.0 -0.2 -1.1
Commuting to job workplace: Car/motor vehicle 1.9 2.2 6.9 2.0 1.3 0.5 -2.6 -2.1 -1.8 -1.7 0.5 -0.1 0.9 -0.2 -1.5
Illness, injury, bereavement, stress in last 2 years 2.1 2.6 8.3 1.2 -0.8 -0.9 0.1 -0.3 1.5 2.2 2.0 0.6 2.9 2.1 2.0
Medication: Aspirin 1.7 2.3 9.1 0.2 1.4 1.1 -0.4 0.3 -1.1 -0.1 -1.0 -2.4 -3.0 -2.4 -0.9
Supplements: Vitamin C 1.5 1.8 7.3 -0.2 2.1 2.7 -1.4 -0.8 -1.2 -0.8 -0.8 -0.8 -0.8 1.0 -1.2
Knee pain experienced in last month 2.3 3.5 10.1 0.1 2.8 3.2 -2.7 -1.8 -2.0 -1.0 -2.0 -0.9 0.1 1.2 -1.5
Hypertension (Self-reported) 5.4 14.9 56.0 -2.9 3.1 2.4 0.0 1.1 -3.6 -2.8 -3.5 -1.8 -7.1 -7.5 -3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 6.1 -1.1 1.8 2.5 0.1 1.1 -0.3 -1.0 -1.8 -1.5 -1.8 -1.0 -1.2
Illnesses of father: Heart disease 2.4 3.3 9.5 -1.9 1.1 1.4 1.2 1.7 -0.0 -0.4 -2.9 -1.3 -2.8 -3.1 -0.8
Illnesses of siblings: Diabetes 1.6 1.9 5.8 0.7 -0.6 -0.9 -0.6 -1.4 0.2 0.8 1.8 -1.7 2.0 2.4 1.5
Smoking status: Previous 8.2 12.3 23.0 -1.1 4.3 4.6 -2.8 -3.4 -4.7 -4.3 -3.5 -2.5 -1.7 -1.3 -4.8
Forced expiratory volume in 1-second (FEV1), predicted 3.0 6.3 23.6 0.7 0.8 1.7 -3.1 -4.0 -2.7 -2.6 0.2 -4.9 0.9 1.4 -2.1
Whole body fat-free mass 3.5 20.0 58.2 2.6 2.6 3.7 -6.0 -7.6 -4.1 -3.0 0.6 -5.7 4.3 5.6 -3.0
Leg fat-free mass (right) 3.5 19.0 58.5 3.0 2.8 3.1 -5.7 -7.7 -3.5 -1.8 0.8 -4.6 5.1 6.7 -1.3
Arm fat percentage (left) 1.0 4.1 17.0 -0.6 2.4 1.6 -0.5 -2.9 -0.8 0.8 -1.4 1.6 2.2 4.1 2.0
Average weekly red wine intake 1.2 1.7 5.2 -0.7 -0.3 -0.6 1.8 1.6 1.5 2.3 -0.6 0.1 -1.2 -0.6 2.2
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.0 0.3 -0.8 -0.5 0.6 -0.3 0.7 -0.0 0.7 -0.9 1.0 0.7 -0.3
Mood swings 0.5 0.8 2.0 0.8 -0.3 -1.3 0.8 1.1 0.7 0.5 0.5 1.4 -0.9 -1.3 0.5
Loneliness, isolation 0.3 0.4 2.2 0.1 0.3 -0.4 1.3 0.3 0.2 -0.0 -0.2 1.5 -0.7 -0.1 0.3
Long-standing illness, disability or infirmity 1.6 2.5 5.8 0.2 1.5 1.2 -1.8 -0.8 -2.1 -1.7 -0.9 -1.6 -1.7 -1.6 -2.4
Ever had bowel cancer screening 1.8 2.1 9.8 0.6 0.9 1.3 -1.5 -0.3 -1.2 -1.6 -0.5 -3.1 -1.4 -1.0 -1.7
Diabetes diagnosed by doctor 1.5 2.4 8.6 -1.6 1.6 2.2 -0.4 -2.9 -0.9 0.6 -1.3 -1.2 1.1 2.1 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 4.1 -2.0 0.7 0.7 0.0 -0.7 -0.6 0.5 -0.1 -0.2 0.5 0.9 0.2
Friendships satisfaction 1.1 1.3 2.5 0.4 -1.2 -0.9 1.6 -0.2 1.1 1.2 0.9 1.5 1.3 0.8 1.5
Qualifications: nursing, teaching 1.4 2.1 8.2 -1.2 -2.3 -0.6 2.9 1.2 1.8 1.6 0.6 0.0 1.1 0.6 1.2
Commuting to job workplace: Walk 1.7 1.8 8.8 -0.7 0.8 0.8 0.9 1.5 -0.3 0.7 -1.1 0.7 -3.0 -2.4 -0.2
Eye problems/disorders: Cataract 1.3 1.5 3.9 -0.3 -2.0 -1.8 -0.1 -0.7 0.5 -0.2 2.0 -0.8 2.0 1.2 0.4
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.4 1.1 0.9 -0.0 -1.2 -0.3 -0.4 -0.2 1.1 -1.1 -0.1 0.1 -0.0
Medication for cholesterol 2.9 4.3 14.7 2.1 -2.0 -1.1 0.9 -1.4 1.5 1.3 1.8 1.9 3.8 3.6 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.1 2.5 7.2 -1.1 2.1 2.7 -1.2 0.0 -1.7 -1.9 -1.1 -0.4 -2.1 -0.6 -1.7
Back pain experienced in last month 3.3 4.8 9.1 -1.1 2.6 3.0 -1.3 -1.5 -2.8 -2.2 -2.9 -1.0 -2.4 -1.7 -2.4
Mineral and other dietary supplements 3.3 4.4 11.1 0.3 -2.5 -3.3 1.9 2.8 2.8 2.3 1.9 1.2 -0.3 -0.8 2.2
Breast cancer (self-reported) 0.9 1.0 3.7 1.9 0.5 0.2 -1.8 -1.1 -1.2 -0.5 0.3 -0.6 -0.2 -0.7 -1.0
Asthma (self-reported) 0.5 0.9 3.2 -0.8 0.3 -0.8 1.2 0.8 0.6 0.5 0.5 1.8 0.6 0.6 1.8
Osteoporosis (self-reported) 1.2 1.5 3.4 -1.4 1.0 1.2 0.7 0.4 -0.9 -0.7 -1.3 1.8 -1.8 -1.5 -1.2
Osteoarthritis (self-reported) 1.7 2.2 5.6 -1.5 1.5 2.4 -0.3 1.1 -0.8 -1.2 -1.6 0.4 -2.1 -2.0 -1.6
Medication: Aspirin 2.1 2.7 10.4 -0.0 1.4 1.2 -0.6 0.5 -1.2 -0.4 -1.3 -2.4 -3.2 -2.7 -1.1
Medication: Gliclazide 1.1 1.2 3.6 -1.6 1.4 1.6 1.1 -1.0 -0.3 0.9 -1.9 0.4 -1.1 0.0 0.4
Illnesses of father: None of the above (group 1) 3.9 4.8 13.8 2.6 -1.9 -2.0 -0.3 -2.5 0.8 1.6 2.8 0.1 3.7 3.0 1.8
Smoking status: Current 9.6 15.2 31.0 -0.6 5.4 5.6 -4.1 -5.2 -5.4 -4.4 -3.1 -1.5 -0.3 1.3 -3.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.4 6.9 -1.2 -0.9 0.4 1.0 0.1 -0.6 -2.4 -1.2 2.2 -1.2 -2.0 -2.6
Whole body water mass 3.4 19.3 57.0 2.5 2.6 3.7 -5.8 -7.5 -4.0 -2.9 0.6 -5.6 4.3 5.5 -2.9
Leg predicted mass (right) 3.5 18.9 57.9 3.0 2.7 3.1 -5.7 -7.6 -3.4 -1.7 0.9 -4.6 5.2 6.7 -1.3
Arm fat mass (left) 1.5 6.3 22.0 -0.1 2.8 2.6 -2.1 -4.5 -2.0 -0.4 -1.2 -0.6 2.8 4.7 0.5
Number of self-reported non-cancer illnesses 0.7 1.2 4.4 -0.4 1.1 0.7 0.2 2.1 0.0 -0.0 -0.1 -0.3 -2.1 -1.9 -0.3
Average weekly champagne plus white wine intake 2.5 3.4 9.0 2.6 -2.1 -2.2 0.1 -1.3 0.6 0.4 2.4 1.7 3.0 2.1 0.1
Miserableness 0.6 1.1 3.6 0.5 0.5 -0.0 -1.2 -1.3 -1.4 -1.9 0.5 -1.2 0.2 -0.6 -1.5
Guilty feelings 0.1 0.2 1.0 0.1 0.1 -0.1 0.9 0.4 0.4 0.2 0.1 1.0 0.0 -0.3 -0.1
Wears glasses or contact lenses 0.6 0.7 2.0 -0.4 -0.7 -0.3 1.3 1.4 0.9 1.0 0.0 -0.2 -0.8 -1.2 -0.0
Ever taken oral contraceptive pill 1.2 1.3 7.0 0.0 -0.0 0.2 -0.5 -1.1 0.3 -0.6 0.0 -0.7 2.5 2.6 -0.2
Hearing aid user 0.6 0.6 2.0 0.9 -1.0 -0.3 -0.7 0.5 -0.1 -1.3 0.8 0.1 0.6 -0.2 -1.4
Mother’s age at death 0.3 0.4 1.3 0.7 -1.0 -1.1 0.8 -0.2 0.5 0.7 -0.4 -0.3 0.3 0.3 0.5
Financial situation satisfaction 3.0 3.7 10.1 1.0 1.8 1.0 -2.8 -3.2 -2.7 -2.2 0.2 -2.2 0.6 1.0 -1.6
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.5 0.2 -0.8 -0.2 -1.2 -0.7 -0.2 -0.5 1.0 -1.1 1.2 0.6 -1.2
Commuting to job workplace: Public transport 1.5 1.8 4.8 -0.8 -2.2 -1.9 1.9 1.2 1.7 1.2 0.7 0.2 0.7 0.1 1.3
Eye problems/disorders: Glaucoma 1.5 1.8 9.0 -1.8 -1.2 0.1 3.0 1.3 1.1 1.1 -0.3 1.5 -0.9 -0.0 1.0
Medication: Blood pressure 5.0 9.6 31.4 -2.8 3.0 2.3 -0.3 0.7 -2.8 -2.3 -3.1 -1.5 -5.5 -5.6 -2.4
Pain type(s) experienced in last month: Hip pain 2.3 2.9 11.7 -2.1 1.4 1.7 1.4 0.3 -0.8 -0.6 -2.8 3.4 -1.4 -1.0 -0.3
Supplements: Fish oil (including cod liver oil) 1.6 2.1 5.8 -0.3 1.8 2.4 -1.2 -1.4 -2.0 -1.4 -1.7 -0.8 -0.4 0.1 -1.5
High cholesterol (Self-reported) 0.2 0.4 2.0 -0.2 0.4 0.4 -0.2 -0.2 -0.8 -0.3 -0.3 -1.4 -0.7 -1.0 -0.5
Medication: Bendroflumethiazide 2.8 4.3 9.7 -1.9 2.0 1.8 -1.3 -0.4 -2.5 -1.3 -1.4 -2.8 -3.1 -2.8 -1.6
Medication: Paracetamol 1.2 1.8 9.7 -2.1 -0.7 -0.0 0.8 3.1 0.7 -1.0 -0.2 0.2 -1.7 -1.3 -0.6
Medication: Lisinopril 1.2 1.5 5.1 -1.7 0.1 0.2 0.5 1.5 -0.2 -0.3 -0.7 -1.4 -2.1 -2.3 -0.2
Medication: Atorvastatin 2.1 2.7 8.2 -0.1 1.3 0.6 -0.5 -0.1 -1.9 -1.8 -1.5 -1.1 -2.7 -2.9 -2.0
Illnesses of father: High blood pressure 1.9 2.4 9.3 -1.2 1.2 0.5 0.5 0.7 -1.2 -2.0 -1.3 0.3 -2.3 -3.0 -1.7
Alcohol drinker status: Never 0.3 0.4 1.3 0.7 -0.5 -0.6 0.4 0.5 0.8 1.1 0.3 0.7 -0.3 -0.8 0.5
Ever smoked 11.8 20.8 40.4 -0.8 6.0 5.8 -4.5 -6.1 -6.4 -5.4 -4.2 -2.6 -1.0 0.6 -5.2
Basal metabolic rate 3.3 18.5 56.5 2.3 2.7 3.5 -5.7 -7.5 -4.0 -2.8 0.4 -5.3 4.2 5.6 -2.6
Leg fat percentage (left) 0.8 3.1 8.2 -1.1 2.6 2.5 -0.3 -2.9 -1.7 -0.5 -2.2 0.8 0.8 2.0 -0.3
Arm fat-free mass (left) 3.2 16.1 49.6 1.9 2.7 3.8 -5.1 -7.0 -4.0 -2.9 -0.1 -5.2 3.2 4.4 -3.1
Number of operations (self-reported) 0.4 0.6 1.6 0.1 -1.2 -0.9 0.2 0.7 1.1 0.2 1.0 0.1 1.3 0.3 -0.0
Average weekly beer plus cider intake 0.6 0.9 5.3 0.6 0.6 0.4 -1.8 -0.2 -0.2 -0.4 0.4 -2.3 0.6 0.8 0.0
Irritability 4.1 6.9 15.6 0.2 4.0 2.8 -2.5 -2.1 -3.9 -3.4 -2.6 -1.1 -2.0 -1.5 -2.9
Risk taking 5.3 7.8 15.6 -0.5 3.9 3.3 -3.6 -2.4 -3.7 -3.8 -2.1 -1.1 -1.1 -0.6 -3.5
Ever had prostate specific antigen (PSA) test 0.6 0.7 3.5 1.9 -0.1 -0.5 -0.4 0.2 0.1 0.5 1.6 0.7 0.2 -1.1 -0.1
Fractured/broken bones in last 5 years 2.3 2.9 7.5 -2.7 -0.1 -0.1 2.4 1.6 0.5 1.0 -2.3 2.7 -1.5 -1.5 1.0
Age started oral contraceptive pill 0.3 0.4 1.6 0.1 -0.3 -0.2 0.3 0.1 0.2 1.3 -0.7 -1.2 -0.3 -0.6 0.5
Diastolic blood pressure, automated reading 8.1 25.0 71.8 -2.8 4.8 4.4 -2.2 0.8 -5.1 -4.2 -4.5 -3.6 -8.5 -8.2 -5.4
Ever depressed for a whole week 0.9 1.1 3.1 -1.3 -0.5 -0.3 0.1 0.5 -0.8 -1.4 -0.3 -1.7 -1.5 -1.8 -0.8
Unable to work because of sickness or disability 4.1 5.3 12.2 0.9 2.2 1.3 -3.2 -1.4 -3.0 -3.2 -0.1 -1.3 -2.0 -2.6 -3.5
Commuting to job workplace: Cycle 0.5 0.6 1.7 -0.6 0.1 -0.1 -0.3 0.1 -0.7 -1.0 -0.3 -0.6 -1.1 -1.3 -1.3
Myopia 0.6 0.8 3.2 -0.3 -0.2 -1.0 0.8 0.1 0.7 1.8 0.5 0.2 0.0 -0.8 1.8
Vascular/heart problems diagnosed by doctor 6.8 18.5 62.9 3.7 -3.8 -3.4 -0.2 -1.5 3.7 2.6 4.4 2.2 7.9 7.7 3.3
Cholesterol lowering medication 1.3 1.9 5.4 -2.3 0.9 1.5 0.5 1.0 -0.7 -0.1 -2.1 -0.2 -2.2 -1.7 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 1.4 -0.3 0.2 0.2 0.2 1.2 0.5 -0.0 -0.5 -1.1 -0.6 -0.5 0.2
Pain experienced in last month 0.4 0.6 2.0 0.4 -0.6 -0.7 0.7 -0.9 0.6 0.8 0.3 -0.5 1.4 1.2 0.4
Supplements: Calcium 2.1 2.3 5.5 -0.5 2.0 1.3 -0.4 -2.2 -2.3 -1.5 -2.0 1.9 -0.8 -0.7 -0.9
Basal cell carcinoma (self-reported) 0.6 0.7 3.2 0.8 -0.6 -0.1 -0.2 1.2 1.1 0.6 0.4 -1.8 0.3 0.6 0.2
Heart attack/myocardial infarction (self-reported) 3.4 4.4 15.5 -2.5 2.1 2.2 0.5 1.5 -1.1 -0.6 -3.4 -0.2 -3.9 -2.5 -0.4
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 6.4 -1.1 -1.6 -1.4 1.5 2.5 2.2 1.5 1.0 1.6 -0.1 0.2 1.8
Heart disease (siblings) 3.6 4.4 12.0 -0.2 1.9 2.0 -1.5 0.4 -2.3 -1.7 -2.0 -1.6 -3.5 -2.9 -2.8
Alcohol drinker status: Previous 0.3 0.3 0.6 -0.2 -0.3 0.1 0.6 0.8 0.4 0.7 -0.3 -0.8 -0.7 -0.6 0.5
Pack years of smoking 2.5 3.7 8.2 -1.5 2.3 1.9 -0.9 -2.6 -2.9 -2.6 -2.5 -0.2 -0.8 0.3 -1.9
Impedance of whole body 1.4 7.1 20.5 -2.0 -2.1 -3.1 2.8 4.1 1.2 0.3 -0.8 -0.0 -4.3 -4.5 0.7
Leg fat mass (left) 2.0 7.6 27.4 -0.1 3.2 3.2 -2.5 -5.2 -2.9 -1.4 -1.6 -1.4 2.4 4.0 -0.9
Arm predicted mass (left) 3.2 16.3 50.1 1.8 2.5 3.7 -5.1 -7.1 -4.1 -3.1 0.1 -5.3 3.4 4.5 -3.2