TWAS hub - CNNM2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Stomach	0.114	0.0720	6.7e-03	0.024	NA	0.068	NA	-0.002	2.4e-02	NA	3.6e-04	NA	4.4e-01
2	ROSMAP	Brain Pre-frontal Cortex	0.105	0.0312	3.1e-08	0.084	0.06	0.069	0.067	0.070	6.0e-11	3.2e-08	2.8e-09	5.7e-09	2.2e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Systolic Blood Pressure	23.2	116.1	231.0	1.1	-15.2
Systolic blood pressure, automated reading	18.3	53.2	106.1	0.6	-10.3
Vascular/heart problems diagnosed by doctor	12.9	35.3	57.9	-3.6	7.6
Schizophrenia (2018)	12.4	25.7	50.9	0.7	-7.1
Schizophrenia (2014)	12.3	27.1	53.9	0.5	-7.3
High blood pressure	12.3	34.2	55.2	3.6	-7.4
Diastolic blood pressure, automated reading	11.8	36.5	60.4	3.6	-7.8
Cardiovascular Disease	11.6	38.3	65.9	3.3	-8.1
Bipolar Disorder or Schizophrenia	11.5	28.0	54.9	1.1	-7.4
Hypertension (Self-reported)	11.2	31.2	52.0	3.2	-7.2
Worry (Nagel 2018)	10.8	22.9	44.8	-1.0	-6.7
High blood pressure (mother)	9.5	13.3	26.6	0.2	-5.2
Medication: Blood pressure	9.2	17.5	28.1	2.6	-5.3
Major Depression (MDD)	9.0	11.0	18.2	1.9	-4.3
Coronary Artery Disease (CAD)	9.0	10.7	21.2	0.5	-4.6
Birth weight	8.5	18.4	28.6	2.9	5.3
Nervous feelings	7.8	14.6	28.6	-0.8	-5.3
Hearing difficulty/problems with background noise	7.8	12.4	22.9	4.8	-1.4
Impedance of leg (left)	7.7	37.4	64.7	3.2	-8.0
Worrier / anxious feelings	7.6	14.3	26.5	-1.5	-5.2
Bipolar Disorder (2011)	7.3	7.0	7.5	2.6	-2.7
Impedance of leg (right)	7.3	35.5	63.1	2.8	-7.9
Birth weight of first child	7.2	13.1	15.5	3.9	3.3
Schizophrenia vs Biploar Disorder	7.0	9.2	17.8	-0.8	-4.2
Neuroticism	6.9	16.6	32.5	-0.9	-5.7
Body Mass Index (BMI) (2010)	6.5	8.9	16.8	-1.0	4.1
Frequency of tenseness / restlessness in last 2 weeks	6.3	9.8	19.5	0.3	-4.4
Tense / ‘highly strung’	6.2	10.2	18.5	1.4	-4.3
Leg fat-free mass (left)	6.1	32.1	58.0	2.5	7.6
Leg predicted mass (left)	5.9	31.2	55.9	2.5	7.5
Forced expiratory volume in 1-second (FEV1), predicted	5.9	12.2	22.9	4.8	1.2
Smoking Status	5.8	14.0	19.8	4.5	2.9
Leg fat-free mass (right)	5.8	31.1	55.7	2.6	7.5
Leg predicted mass (right)	5.8	31.1	56.0	2.5	7.5
Sitting height	5.7	40.3	76.9	8.8	-1.9
Angina (self-reported)	5.7	7.5	11.0	2.0	-3.3
Pulse wave peak to peak time	5.6	6.6	6.9	2.6	2.5
Allergy	5.5	12.5	24.6	5.0	-0.7
Medication: Aspirin	5.5	7.2	8.2	2.5	-2.9
Illnesses of father: Heart disease	5.4	7.5	13.4	1.3	-3.7
Exposure to tobacco smoke outside home	5.3	7.0	9.0	3.0	2.3
Medication: Atenolol	5.2	6.5	7.5	2.4	-2.7
Heart disease (siblings)	5.2	6.3	11.0	1.3	-3.3
Migraine (self-reported)	5.1	6.3	12.2	0.6	3.5
Illnesses of father: None of the above (group 1)	5.1	6.3	12.7	0.1	3.6
BMI	4.9	28.3	52.1	-2.1	7.2
Medication for cholesterol	4.9	7.5	12.2	-1.7	3.5
Hayfever, allergic rhinitis or eczema	4.8	10.3	20.5	-4.5	0.4
Whole body fat-free mass	4.8	27.3	39.3	3.9	6.3
Basal metabolic rate	4.8	26.4	38.6	3.8	6.2
Ulcerative Colitis	4.7	6.8	12.0	3.5	-1.3
Past tobacco smoking	4.7	8.7	16.2	-4.0	-1.1
Whole body water mass	4.7	26.9	38.4	3.9	6.2
Allergy or Eczema	4.6	12.2	23.9	-4.9	0.7
Hayfever/allergic rhinitis (self-reported)	4.6	6.1	12.1	-3.5	0.3
Heart attack	4.5	5.7	9.8	1.3	-3.1
Weight	4.5	22.1	33.0	3.4	5.7
Seen a psychiatrist for nerves, anxiety, tension or depression	4.5	5.9	11.7	0.0	-3.4
Angina	4.4	5.8	8.1	1.9	-2.9
Neck or shoulder pain in last month	4.4	6.2	7.4	2.2	-2.7
Illness, injury, bereavement, stress in last 2 years	4.4	5.3	6.8	-2.0	2.6
Smoking status: Current	4.4	7.0	9.9	3.1	2.0
Medication: Atorvastatin	4.4	5.4	8.6	1.5	-2.9
Neuroticism (Nagel 2018)	4.3	10.1	19.9	-0.5	-4.5
Medication: Ramipril	4.3	5.5	10.2	-0.8	-3.2
Trunk predicted mass	4.3	24.5	26.0	4.8	5.1
Standing height	4.3	42.7	80.3	9.0	2.3
Comparative height size at age 10	4.3	23.8	33.8	5.8	3.7
Medication: Aspirin	4.3	5.7	6.5	2.2	-2.5
Trunk fat-free mass	4.2	24.1	25.4	4.8	5.0
Mouth/teeth dental problems: Loose teeth	4.2	4.9	6.1	-2.5	1.9
Suffer from ‘nerves’	4.2	6.7	13.3	0.1	-3.6
Arm fat-free mass (left)	4.2	21.2	24.8	4.2	5.0
Current tobacco smoking	4.1	6.7	10.0	3.2	1.9
Maternal smoking around birth	4.1	5.9	9.4	3.1	1.5
Heart attack/myocardial infarction (self-reported)	4.1	5.3	9.4	1.1	-3.1
Lung cancer (father)	3.9	4.5	6.4	1.6	2.5
Pulse wave Arterial Stiffness index	3.9	4.5	4.6	-2.1	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	3.9	5.9	9.8	1.4	-3.1
Arm fat-free mass (right)	3.9	20.2	22.7	4.2	4.8
Arm predicted mass (right)	3.9	19.7	21.9	4.2	4.7
Impedance of whole body	3.9	20.1	37.4	1.7	-6.1
Arm predicted mass (left)	3.9	20.0	24.5	3.9	4.9
Commuting to job workplace: Walk	3.8	4.1	8.1	0.3	-2.8
Hip circumference	3.7	16.1	26.1	2.5	5.1
Blood White Count	3.6	26.8	37.2	6.1	-4.0
Ever smoked	3.6	6.4	11.0	3.3	1.4
Height	3.4	66.2	118.8	10.9	3.7
Townsend deprivation index at recruitment	3.4	4.8	5.5	2.0	2.3
Forced vital capacity (FVC)	3.4	13.0	21.5	4.6	-2.1
Illnesses of mother	3.4	4.2	7.1	-1.1	2.7
Medication: Blood pressure	3.4	6.1	11.5	0.8	-3.4
Reaction Time	3.3	6.3	10.3	-3.2	-1.5
Hand grip strength (left)	3.3	8.7	14.0	3.7	1.9
Neuroticism score	3.3	6.9	13.7	-0.5	-3.7
Ever highly irritable/argumentative for 2 days	3.3	4.0	4.2	1.9	-2.1
Depression (Nagel 2018)	3.2	4.8	8.2	1.1	-2.9
Neuroticism (2016)	3.2	4.6	5.1	-2.0	-2.2
Body mass index (BMI)	3.2	13.4	26.4	-0.7	5.1
Trunk fat mass	3.2	13.8	23.2	2.1	4.8
Leg fat mass (right)	3.2	12.3	18.8	2.4	4.3
Mineral and other dietary supplements	3.2	4.3	7.6	-2.8	-1.0
Illnesses of father: High blood pressure	3.2	4.0	7.2	0.9	-2.7
Arm fat mass (right)	3.1	12.6	23.8	1.2	4.9
Worry too long after embarrassment	3.1	5.1	8.4	-1.4	-2.9
Whole body fat mass	3.1	12.8	22.0	1.9	4.7
Arm fat mass (left)	3.1	12.9	24.6	1.1	5.0
Medication: Bendroflumethiazide	3.1	4.7	6.9	1.6	-2.6
Medication: Lisinopril	3.1	4.0	7.0	1.0	-2.6
Leg fat mass (left)	3.1	12.1	18.2	2.5	4.3
Bipolar Disorder (2018)	3.0	4.8	9.0	0.7	-3.0
Frequency of depressed mood in last 2 weeks	3.0	4.2	5.3	2.3	-1.8
High blood pressure (siblings)	2.9	4.2	7.8	0.8	-2.8
Severe depression (siblings)	2.8	3.2	6.3	0.2	-2.5
Alcohol intake frequency.	2.8	6.5	12.9	3.6	-0.3
Blood Red Count	2.7	26.0	49.6	1.6	-7.0
Pulse wave reflection index	2.7	3.4	6.7	0.2	2.6
Ever taken oral contraceptive pill	2.7	3.0	5.9	0.4	2.4
Ever depressed for a whole week	2.7	3.3	4.0	1.6	-2.0
Other serious medical condition/disability diagnosed by doctor	2.6	3.4	4.4	1.6	-2.1
Supplements: Zinc	2.6	2.8	5.6	2.4	0.0
Long-standing illness, disability or infirmity	2.6	3.9	5.8	2.4	-1.4
Number of treatments/medications taken	2.5	4.5	7.7	1.1	-2.8
Hearing difficulty/problems: Yes	2.5	3.8	6.2	2.5	-1.2
Had menopause	2.5	3.1	4.2	-1.4	-2.1
Miserableness	2.5	4.4	8.7	3.0	0.1
Prostate Cancer	2.4	3.3	6.7	-2.6	0.2
Respiratory disease	2.4	5.4	9.5	-3.1	1.1
Serious illness, injury or assault to yourself	2.4	2.9	5.4	0.6	-2.3
Hair/balding pattern: Pattern 3	2.4	3.5	4.7	1.5	-2.2
Medication for cholesterol, blood pressure or diabetes	2.4	4.0	7.3	-0.9	2.7
Medication: Amlodipine	2.4	3.4	6.6	0.3	-2.6
Forced vital capacity (FVC), Best measure	2.4	8.8	14.9	3.9	-1.7
Supplements: Glucosamine	2.3	3.0	5.8	2.4	-0.3
Waist circumference	2.3	8.4	14.1	1.7	3.8
Arm fat percentage (right)	2.3	9.0	18.0	-0.1	4.2
Illnesses of siblings: Diabetes	2.3	2.9	4.4	1.1	2.1
Sensitivity / hurt feelings	2.2	3.7	6.4	1.0	-2.5
Medication: Metformin	2.2	3.0	5.9	0.4	2.4
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	5.0	0.2	-2.2
Arm fat percentage (left)	2.2	8.9	17.8	-0.2	4.2
Diabetes diagnosed by doctor	2.2	3.6	5.8	1.2	2.4
Back pain experienced in last month	2.2	3.2	5.0	2.2	-1.2
Hand grip strength (right)	2.1	5.8	8.5	2.9	1.7
Forced expiratory volume in 1-second (FEV1)	2.1	7.0	11.7	3.4	-1.5
Asthma	2.1	4.1	7.6	-2.8	0.8
Exposure to tobacco smoke at home	2.1	2.4	4.3	0.7	2.1
Breastfed as a baby	2.1	2.6	4.9	-0.6	-2.2
Lupus	2.0	3.0	4.3	2.1	1.3
Ever used hormone-replacement therapy (HRT)	2.0	2.6	2.9	-1.5	-1.7
Age when periods started (menarche)	2.0	4.8	7.4	1.4	2.7
Number of live births	2.0	2.8	5.3	0.6	-2.3
Comparative body size at age 10	2.0	5.7	11.2	0.3	3.4
Diabetes (mother)	1.9	2.4	3.8	1.0	1.9
Diabetes (self-reported)	1.9	2.9	4.8	1.1	2.2
Peak expiratory flow (PEF)	1.9	4.5	7.3	2.7	1.3
Wheeze or whistling in the chest in last year	1.9	3.4	3.7	-1.9	1.8
Mean time to correctly identify matches	1.9	3.7	4.6	-2.1	-1.7
Smoking status: Previous	1.9	2.8	5.3	2.3	-0.5
Type 2 Diabetes (T2D) (2018)	1.8	3.3	6.4	0.4	2.5
Medication: Seretide 50 evohaler	1.8	2.1	3.0	-1.1	1.7
Pulse rate, automated reading	1.8	5.9	11.7	0.2	-3.4
Asthma (self-reported)	1.8	3.5	6.6	-2.6	0.7
Unable to work because of sickness or disability	1.8	2.3	2.9	1.3	-1.7
Average weekly fortified wine intake	1.7	2.0	3.6	-1.9	0.6
Hair/balding pattern: Pattern 2	1.7	2.1	4.1	-0.4	2.0
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	2.7	1.2	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.5	9.3	3.0	-1.3
Length of working week for main job	1.7	1.9	3.3	1.8	0.6
Blood clot in the leg (DVT)	1.7	2.2	4.3	-2.1	-0.3
Fractured/broken bones in last 5 years	1.7	2.2	4.4	-0.2	-2.1
Heel T-Score	1.6	12.4	24.2	-0.8	4.9
Financial difficulties in last 2 years	1.6	2.1	4.2	2.0	-0.2
Illnesses of siblings	1.6	2.3	3.9	-0.8	2.0
Loud music exposure frequency	1.6	1.7	3.4	1.8	-0.2
Knee pain experienced in last month	1.6	2.5	2.5	1.6	1.6
Financial situation satisfaction	1.6	1.9	2.2	1.3	1.5
Blood Platelet Count	1.5	17.2	34.3	5.9	0.4
Lung FVC	1.5	7.6	15.1	0.3	-3.9
Medication: Co-codamol	1.5	1.7	3.1	-0.6	-1.8
Trunk fat percentage	1.5	6.1	11.6	0.7	3.4
Falls in the last year	1.5	2.0	2.9	1.1	-1.7
Pulse rate	1.5	2.5	3.3	-1.8	-1.3
Age at first live birth	1.5	2.7	3.6	-1.3	1.9
Osteoporosis (self-reported)	1.5	1.9	3.4	-0.5	-1.8
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.0	2.0	0.2
Irritability	1.5	2.5	4.4	2.1	-0.8
Age at First Birth	1.4	2.1	4.1	-0.2	2.0
Crohns Disease (2012)	1.4	2.3	4.6	2.1	-0.3
Mean Putamen Volume	1.4	1.6	2.4	1.6	0.9
Alcohol intake versus 10 years previously	1.4	2.1	3.2	1.8	1.0
Heart disease (mother)	1.4	1.7	3.1	0.5	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	4.4	1.2	-2.1
Average weekly champagne plus white wine intake	1.4	1.9	3.8	-0.2	1.9
Cholesterol lowering medication	1.4	2.1	4.2	0.3	-2.0
Deep venous thrombosis (DVT) (self-reported)	1.4	1.9	3.6	-1.9	-0.4
Ulcerative Colitis (UC)	1.3	2.4	4.6	2.2	-0.3
Impedance of arm (left)	1.3	6.1	12.1	0.1	-3.5
Health satisfaction	1.3	1.7	3.4	1.9	-0.0
Verbal and Numeric Reasoning (VNR)	1.2	2.8	4.7	2.2	1.0
Multivitamins +/- minerals	1.2	1.5	3.0	1.7	0.0
Number of incorrect matches in round	1.2	2.0	3.9	0.0	-2.0
Fluid intelligence score	1.2	2.5	2.8	1.7	1.5
Impedance of arm (right)	1.2	5.6	11.2	0.1	-3.3
Body fat percentage	1.2	4.7	8.6	0.9	2.9
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.5	0.6	-1.6
Overall health rating	1.2	2.5	4.3	2.1	-0.8
Family relationship satisfaction	1.2	1.5	1.8	1.1	-1.4
Noisy workplace	1.1	1.3	2.6	1.6	0.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.2	-1.5	0.8
Medication for pain relief, constipation, heartburn	1.1	1.9	3.9	-0.1	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.2	1.5	-0.7
Chronic bronchitis/emphysema (father)	1.0	1.2	2.3	-1.5	-0.2
Medication: Allopurinol	1.0	1.3	1.4	1.2	-1.1
Ever had bowel cancer screening	1.0	1.1	2.0	1.4	-0.5
Osteoarthritis (self-reported)	1.0	1.2	2.3	-0.4	-1.5
Medication: Paracetamol	1.0	1.6	3.2	-0.0	-1.8
Commuting to job workplace: Cycle	1.0	1.2	2.2	-0.4	-1.5
Pain experienced in last month	1.0	1.7	2.1	-1.4	1.1
Irritable Bowel Disease (IBD)	0.9	2.2	3.6	1.9	-0.9
HbA1C	0.9	1.0	1.5	-1.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.0	-0.4	-1.4
Mouth/teeth dental problems: Dentures	0.9	1.5	3.0	-0.1	1.7
Prospective memory result	0.9	1.2	2.1	-1.5	0.4
Medication: Paracetamol	0.9	1.4	2.8	0.2	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	1.7	1.3	-0.6
Leg fat percentage (left)	0.9	3.1	4.2	1.4	2.0
Average weekly beer plus cider intake	0.9	1.3	2.6	-0.0	1.6
Triglycerides	0.8	1.3	1.5	1.0	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	3.1	0.7	1.8
Glaucoma (self-reported)	0.8	1.0	1.8	-0.3	-1.4
Leg fat percentage (right)	0.8	2.8	3.9	1.2	2.0
Number of children fathered	0.8	0.9	1.7	1.3	-0.2
Had major operations	0.8	0.9	1.1	1.1	0.9
Number of self-reported non-cancer illnesses	0.8	1.5	2.8	-0.4	-1.7
Risk taking	0.8	1.2	2.3	1.5	0.2
Pack years of smoking	0.8	1.1	2.1	1.4	0.4
Blood Eosinophil Count	0.7	5.8	11.2	3.4	-0.5
Lung FEV1/FVC ratio	0.7	3.6	7.1	-0.4	2.7
Fed-up feelings	0.7	1.3	2.2	-1.5	0.6
Alcohol usually taken with meals	0.7	1.1	1.7	-1.3	-0.7
Qualifications: A levels/AS levels or equivalent	0.7	1.4	2.7	1.6	-0.4
Medication: Cholesterol lowering	0.7	1.0	1.3	0.9	-1.1
Hair/balding pattern: Pattern 4	0.7	1.7	2.4	-1.0	1.5
Number of full sisters	0.7	0.9	1.7	0.3	1.3
Chest pain or discomfort	0.7	1.0	1.9	0.5	-1.4
Age at last live birth	0.7	1.1	1.9	-0.5	1.4
Wears glasses or contact lenses	0.7	0.9	1.7	0.0	-1.3
Alcohol drinker status: Previous	0.7	0.8	1.4	1.2	-0.5
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.4	1.9	0.6
Alzheimer’s Disease (in father)	0.6	0.7	0.8	-0.9	-0.8
Breast Cancer	0.6	1.4	2.5	-1.6	0.6
HDL Cholesterol	0.6	1.0	1.1	1.0	-1.0
Hypothyroidism (self reported)	0.6	1.3	1.4	1.1	1.2
Tanning	0.6	7.3	9.7	3.1	2.2
Average weekly spirits intake	0.6	0.8	1.6	0.1	1.3
Vitamin and mineral supplements	0.6	0.8	1.5	-1.2	-0.3
Pack years adult smoking proportion	0.6	0.9	1.6	1.3	0.4
Depression (self-reported)	0.6	0.7	1.2	1.1	-0.4
Emphysema/chronic bronchitis	0.6	0.7	1.3	0.2	1.2
Leg pain on walking	0.6	0.8	1.6	0.1	-1.3
Mother’s age at death	0.6	0.7	1.3	1.1	-0.5
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.1	-1.0	-0.6
Supplements: Calcium	0.6	0.7	0.8	0.9	-0.8
Alzheimer’s Disease (including proxy)	0.5	0.7	1.3	-1.1	-0.4
Fasting Glucose	0.5	0.6	1.2	1.1	0.3
Taking other prescription medications	0.5	0.7	0.9	0.7	-1.0
Had other major operations	0.5	0.6	1.1	-0.4	-1.1
Mouth/teeth dental problems	0.5	0.7	0.9	0.7	-1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.3	-0.3	1.1
Number of full brothers	0.5	0.6	0.8	0.6	-0.9
Supplements: Vitamin C	0.5	0.6	1.2	-0.1	1.1
Average weekly red wine intake	0.5	0.7	1.0	-1.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.4	-1.2	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.0	-0.3	-1.0
Medication: Gliclazide	0.5	0.6	1.1	1.1	-0.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.6	-0.7	0.8
Commuting to job workplace: Public transport	0.5	0.7	0.7	0.8	-0.8
Eye problems/disorders: Glaucoma	0.5	0.6	1.0	-0.3	-1.0
High cholesterol (Self-reported)	0.5	0.8	1.0	1.0	-0.9
Basal cell carcinoma (self-reported)	0.5	0.5	1.0	1.0	0.4
Crohns Disease (2017)	0.4	0.8	1.2	1.1	-0.6
Ovarian Cancer	0.4	0.5	1.0	0.2	1.0
Chronotype (morning person)	0.4	0.9	1.2	1.1	0.8
Medication: Simvastatin	0.4	0.6	0.8	0.9	-0.6
Gout (self-reported)	0.4	0.6	0.7	0.6	-0.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.7	0.4	0.9
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.8	-0.3	0.9
Mood swings	0.4	0.7	1.0	-0.7	-1.0
Eye problems/disorders: Cataract	0.4	0.4	0.9	-0.1	0.9
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.6	-0.5	-0.8
Depressed Affect (Nagel 2018)	0.3	0.7	1.4	0.0	-1.2
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.8	0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	-0.1	-0.8
Relative age of first facial hair	0.3	0.5	0.7	0.8	0.6
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	-0.9	0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.3	0.6	0.5
Diabetes (father)	0.3	0.4	0.7	0.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.4	0.2	1.2
Pain all over the body in last month	0.3	0.3	0.4	-0.5	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.6	0.7	0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.8	0.9	-0.5
Shortness of breath walking on level ground	0.3	0.4	0.6	-0.8	0.3
Eye problems/disorders: None of the above	0.3	0.3	0.6	0.2	0.8
Friendships satisfaction	0.3	0.4	0.6	-0.4	0.8
Number of operations (self-reported)	0.3	0.5	0.6	0.8	0.6
Age started oral contraceptive pill	0.3	0.3	0.4	0.6	-0.5
Primary Biliary Cirrhosis	0.2	0.3	0.5	0.3	-0.7
Waist Hip Ratio (WHR)	0.2	1.1	2.1	0.0	-1.5
Relative age voice broke	0.2	0.3	0.5	0.3	-0.7
Qualifications: CSEs or equivalent	0.2	0.3	0.6	-0.1	0.8
Medication: Levothyroxine sodium	0.2	0.3	0.3	0.6	-0.6
Father’s age at death	0.2	0.3	0.5	-0.7	0.2
Medication: Lansoprazole	0.2	0.2	0.4	0.3	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.9	0.9	-0.2
Qualifications: College or University degree	0.2	0.7	1.3	0.2	-1.2
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.3	-0.5	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.3	-0.5	0.5
Guilty feelings	0.2	0.4	0.7	-0.9	-0.1
Hearing aid user	0.2	0.2	0.3	0.6	0.1
LDL Cholesterol	0.1	0.2	0.3	0.2	-0.5
Rheumatoid Arthritis	0.1	0.2	0.2	0.5	-0.4
Hair Pigment	0.1	1.9	2.1	-1.4	-1.3
Medication for hormone replacement therapy	0.1	0.2	0.2	0.4	0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.3	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.0	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	-0.3	0.2
Time employed in main current job	0.1	0.1	0.2	-0.2	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.4	-0.2
Headache pain in last month	0.1	0.2	0.3	0.4	0.6
Medication: Ibuprofen	0.1	0.1	0.2	-0.4	-0.3
Medication: Omeprazole	0.1	0.1	0.3	0.0	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	0.4	-0.2
Breast cancer (self-reported)	0.1	0.1	0.2	0.0	-0.4
Alcohol drinker status: Never	0.1	0.2	0.2	0.5	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.2	-0.4	-0.4
Qualifications: None of the above	0.0	0.0	0.0	0.1	-0.0
Happiness	0.0	0.0	0.0	0.0	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	-0.1	-0.0
Loneliness, isolation	0.0	0.0	0.1	-0.3	0.1
Qualifications: nursing, teaching	0.0	0.1	0.1	0.1	-0.3
Myopia	0.0	0.1	0.1	-0.2	-0.3

Hub : Genes

CNNM2

Models

Trait associations