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chr15:67,138,238-68,789,191

Best TWAS P=1.78e-08 · Best GWAS P=7.06e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Adipose Visceral Omentum	MAP2K5	0.07	0.08	lasso	3	0.05	1.0e-03	5.6	-5.6	1.8e-08	-0.96	0.01	0.98	TRUE
6	GTEx	Breast Mammary Tissue	MAP2K5	0.14	0.07	lasso	5	0.09	2.8e-05	4.6	-5.5	4.0e-08	-0.86	0.03	0.96	FALSE
4	GTEx	Artery Tibial	MAP2K5	0.15	0.18	lasso	3	0.18	6.3e-14	5.2	-5.4	6.5e-08	-0.95	0.02	0.98	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	MAP2K5	0.10	0.06	lasso	5	0.04	6.1e-05	5.1	-5.3	8.9e-08	-0.93	0.00	0.99	FALSE
16	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCH	0.04	0.02	enet	6	0.03	1.6e-04	5.6	-5.3	9.1e-08	-0.85	0.02	0.96	FALSE
8	GTEx	Heart Atrial Appendage	MAP2K5	0.16	0.08	lasso	5	0.16	1.3e-07	5.1	-5.3	9.8e-08	-0.87	0.02	0.97	FALSE
11	GTEx	Ovary	MAP2K5	0.19	0.24	lasso	3	0.21	8.3e-06	5.1	-5.3	9.9e-08	-0.94	0.02	0.95	FALSE
15	NTR	Blood	MAP2K5	0.02	0.00	enet	13	0.01	5.7e-04	5.8	-5.3	9.9e-08	-0.87	0.00	0.99	FALSE
3	GTEx	Artery Aorta	MAP2K5	0.06	0.05	enet	6	0.05	7.7e-04	5.1	-5.3	1.3e-07	-0.92	0.02	0.97	FALSE
7	GTEx	Esophagus Muscularis	MAP2K5	0.24	0.14	lasso	4	0.13	2.1e-08	5.1	-5.2	1.6e-07	-0.95	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	MAP2K5	0.14	0.18	lasso	4	0.18	1.0e-14	5.1	-5.2	2.1e-07	-0.95	0.02	0.98	FALSE
12	GTEx	Skin Sun Exposed Lower leg	MAP2K5	0.13	0.06	lasso	4	0.09	4.4e-08	-3.9	-5.2	2.2e-07	-0.80	0.14	0.86	FALSE
5	GTEx	Brain Cerebellum	MAP2K5	0.27	0.12	lasso	5	0.14	7.9e-05	4.9	-5.2	2.4e-07	-0.87	0.08	0.84	FALSE
10	GTEx	Nerve Tibial	MAP2K5	0.19	0.21	lasso	2	0.20	3.3e-14	5.2	-5.2	2.5e-07	-0.94	0.04	0.96	FALSE
14	GTEx	Whole Blood	MAP2K5	0.09	0.06	lasso	6	0.06	8.1e-06	5.2	-5.1	2.6e-07	-0.90	0.03	0.97	FALSE
9	GTEx	Heart Left Ventricle	MAP2K5	0.10	0.10	lasso	3	0.10	9.4e-06	5.1	-5.1	2.8e-07	-0.94	0.01	0.99	FALSE
13	GTEx	Thyroid	MAP2K5	0.11	0.16	lasso	4	0.15	9.6e-12	5.1	-5.1	2.9e-07	-0.94	0.02	0.98	FALSE