Best TWAS P=7.46e-16 · Best GWAS P=1.19e-14 conditioned to 0.00961
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DLST | 0.09 | 0.11 | lasso | 2 | 0.11 | 4.0e-13 | -7.3 | 7.6 | 3.8e-14 | -0.74 | 0.06 | 0.94 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RPS6KL1 | 0.04 | 0.02 | lasso | 5 | 0.02 | 4.8e-04 | 4.8 | -6.4 | 1.4e-10 | 0.61 | 0.14 | 0.60 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | YLPM1 | 0.10 | 0.03 | lasso | 6 | 0.02 | 7.9e-03 | -7.2 | 7.7 | 1.7e-14 | -0.58 | 0.07 | 0.52 | FALSE |
| 4 | GTEx | Adrenal Gland | RPS6KL1 | 0.21 | 0.13 | enet | 25 | 0.15 | 4.4e-06 | 5.2 | 5.6 | 1.6e-08 | -0.57 | 0.32 | 0.60 | FALSE |
| 5 | GTEx | Colon Sigmoid | MLH3 | 0.17 | 0.02 | enet | 9 | 0.00 | 2.4e-01 | -1.4 | -6.1 | 9.7e-10 | 0.23 | 0.06 | 0.45 | FALSE |
| 6 | GTEx | Lung | RPS6KL1 | 0.09 | 0.09 | enet | 24 | 0.08 | 1.8e-06 | 4.8 | 5.6 | 2.5e-08 | -0.60 | 0.46 | 0.52 | FALSE |
| 7 | GTEx | Muscle Skeletal | DLST | 0.28 | 0.26 | enet | 23 | 0.26 | 2.1e-25 | -7.5 | -7.7 | 1.7e-14 | 0.34 | 0.04 | 0.96 | FALSE |
| 8 | GTEx | Nerve Tibial | YLPM1 | 0.08 | 0.06 | lasso | 1 | 0.04 | 5.1e-04 | 5.7 | 5.7 | 1.1e-08 | -0.67 | 0.08 | 0.75 | FALSE |
| 9 | GTEx | Nerve Tibial | RPS6KL1 | 0.17 | 0.24 | lasso | 6 | 0.19 | 2.3e-13 | 4.9 | 5.4 | 5.1e-08 | -0.59 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Prostate | RPS6KL1 | 0.26 | 0.10 | lasso | 3 | 0.17 | 4.6e-05 | 5.7 | 5.1 | 3.0e-07 | -0.65 | 0.07 | 0.81 | FALSE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | RPS6KL1 | 0.08 | 0.08 | enet | 11 | 0.07 | 1.5e-04 | 7.4 | 8.1 | 7.5e-16 | -0.74 | 0.06 | 0.93 | TRUE |
| 12 | GTEx | Skin Sun Exposed Lower leg | RPS6KL1 | 0.15 | 0.13 | lasso | 4 | 0.12 | 1.8e-10 | 4.8 | 5.5 | 3.1e-08 | -0.68 | 0.76 | 0.24 | FALSE |
| 13 | GTEx | Spleen | NPC2 | 0.30 | 0.08 | enet | 10 | 0.06 | 1.5e-02 | 6.2 | 5.9 | 3.4e-09 | -0.77 | 0.12 | 0.37 | FALSE |
| 14 | GTEx | Stomach | RPS6KL1 | 0.09 | -0.01 | enet | 16 | 0.00 | 3.3e-01 | -4.0 | 5.4 | 6.6e-08 | -0.30 | 0.05 | 0.64 | FALSE |
| 15 | GTEx | Testis | AREL1 | 0.20 | 0.14 | enet | 34 | 0.13 | 2.1e-06 | 7.3 | 7.9 | 2.0e-15 | -0.78 | 0.06 | 0.93 | FALSE |
| 16 | METSIM | Adipose | ACYP1 | 0.03 | 0.02 | blup | 413 | 0.02 | 4.0e-04 | -2.6 | 5.4 | 7.0e-08 | -0.51 | 0.68 | 0.26 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPS6KL1 | 0.03 | 0.02 | lasso | 3 | 0.02 | 8.5e-06 | 7.3 | 7.1 | 1.0e-12 | -0.77 | 0.04 | 0.96 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPS6KL1 | 0.04 | 0.04 | lasso | 3 | 0.03 | 1.8e-04 | 7.3 | 7.0 | 3.1e-12 | -0.76 | 0.04 | 0.94 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RPS6KL1 | 0.09 | 0.10 | blup | 49 | 0.11 | 5.1e-07 | -4.4 | 5.8 | 8.2e-09 | -0.39 | 0.66 | 0.31 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Adenocarcinoma | RPS6KL1 | 0.03 | 0.01 | blup | 49 | 0.02 | 2.3e-03 | 5.7 | 6.3 | 2.9e-10 | -0.54 | 0.04 | 0.37 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPS6KL1 | 0.09 | 0.04 | enet | 6 | 0.06 | 1.1e-06 | 4.8 | 5.2 | 2.5e-07 | -0.55 | 0.69 | 0.30 | FALSE |