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chr14:74,245,607-76,226,003

Best TWAS P=7.46e-16 · Best GWAS P=1.19e-14 conditioned to 0.00961

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	GTEx	Skin Not Sun Exposed Suprapubic	RPS6KL1	0.08	0.08	enet	11	0.07	1.5e-04	7.4	8.1	7.5e-16	-0.74	0.06	0.93	TRUE
15	GTEx	Testis	AREL1	0.20	0.14	enet	34	0.13	2.1e-06	7.3	7.9	2.0e-15	-0.78	0.06	0.93	FALSE
3	GTEx	Adipose Subcutaneous	YLPM1	0.10	0.03	lasso	6	0.02	7.9e-03	-7.2	7.7	1.7e-14	-0.58	0.07	0.52	FALSE
7	GTEx	Muscle Skeletal	DLST	0.28	0.26	enet	23	0.26	2.1e-25	-7.5	-7.7	1.7e-14	0.34	0.04	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DLST	0.09	0.11	lasso	2	0.11	4.0e-13	-7.3	7.6	3.8e-14	-0.74	0.06	0.94	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS6KL1	0.03	0.02	lasso	3	0.02	8.5e-06	7.3	7.1	1.0e-12	-0.77	0.04	0.96	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPS6KL1	0.04	0.04	lasso	3	0.03	1.8e-04	7.3	7.0	3.1e-12	-0.76	0.04	0.94	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RPS6KL1	0.04	0.02	lasso	5	0.02	4.8e-04	4.8	-6.4	1.4e-10	0.61	0.14	0.60	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	RPS6KL1	0.03	0.01	blup	49	0.02	2.3e-03	5.7	6.3	2.9e-10	-0.54	0.04	0.37	FALSE
5	GTEx	Colon Sigmoid	MLH3	0.17	0.02	enet	9	0.00	2.4e-01	-1.4	-6.1	9.7e-10	0.23	0.06	0.45	FALSE
13	GTEx	Spleen	NPC2	0.30	0.08	enet	10	0.06	1.5e-02	6.2	5.9	3.4e-09	-0.77	0.12	0.37	FALSE
19	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RPS6KL1	0.09	0.10	blup	49	0.11	5.1e-07	-4.4	5.8	8.2e-09	-0.39	0.66	0.31	FALSE
8	GTEx	Nerve Tibial	YLPM1	0.08	0.06	lasso	1	0.04	5.1e-04	5.7	5.7	1.1e-08	-0.67	0.08	0.75	FALSE
4	GTEx	Adrenal Gland	RPS6KL1	0.21	0.13	enet	25	0.15	4.4e-06	5.2	5.6	1.6e-08	-0.57	0.32	0.60	FALSE
6	GTEx	Lung	RPS6KL1	0.09	0.09	enet	24	0.08	1.8e-06	4.8	5.6	2.5e-08	-0.60	0.46	0.52	FALSE
12	GTEx	Skin Sun Exposed Lower leg	RPS6KL1	0.15	0.13	lasso	4	0.12	1.8e-10	4.8	5.5	3.1e-08	-0.68	0.76	0.24	FALSE
9	GTEx	Nerve Tibial	RPS6KL1	0.17	0.24	lasso	6	0.19	2.3e-13	4.9	5.4	5.1e-08	-0.59	1.00	0.00	FALSE
14	GTEx	Stomach	RPS6KL1	0.09	-0.01	enet	16	0.00	3.3e-01	-4.0	5.4	6.6e-08	-0.30	0.05	0.64	FALSE
16	METSIM	Adipose	ACYP1	0.03	0.02	blup	413	0.02	4.0e-04	-2.6	5.4	7.0e-08	-0.51	0.68	0.26	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPS6KL1	0.09	0.04	enet	6	0.06	1.1e-06	4.8	5.2	2.5e-07	-0.55	0.69	0.30	FALSE
10	GTEx	Prostate	RPS6KL1	0.26	0.10	lasso	3	0.17	4.6e-05	5.7	5.1	3.0e-07	-0.65	0.07	0.81	FALSE