Best TWAS P=3.51e-08 · Best GWAS P=6.21e-08 conditioned to 0.404
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | DTD1 | 0.09 | 0.04 | lasso | 2 | 0.03 | 3.8e-03 | -5.1 | 5.2 | 2.3e-07 | -0.85 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Esophagus Muscularis | RBBP9 | 0.08 | 0.03 | lasso | 2 | 0.00 | 2.1e-01 | -5.4 | 5.4 | 7.7e-08 | -0.97 | 0.02 | 0.86 | FALSE |
| 3 | GTEx | Muscle Skeletal | DTD1 | 0.08 | 0.07 | lasso | 2 | 0.05 | 7.1e-06 | -5.4 | 5.4 | 6.1e-08 | -0.97 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Ovary | DTD1 | 0.27 | 0.20 | lasso | 2 | 0.18 | 3.3e-05 | -5.3 | 5.3 | 9.6e-08 | -0.88 | 0.02 | 0.91 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | DTD1 | 0.14 | 0.14 | lasso | 4 | 0.13 | 8.9e-08 | -5.2 | 5.5 | 3.5e-08 | -0.92 | 0.02 | 0.98 | TRUE |
| 6 | GTEx | Skin Sun Exposed Lower leg | DTD1 | 0.15 | 0.07 | lasso | 6 | 0.10 | 2.7e-08 | -4.6 | 5.2 | 2.3e-07 | -0.89 | 0.03 | 0.97 | FALSE |
| 7 | GTEx | Testis | LINC00493 | 0.11 | 0.05 | lasso | 5 | 0.03 | 1.3e-02 | -5.4 | 5.3 | 1.2e-07 | -0.93 | 0.02 | 0.94 | FALSE |
| 8 | The Cancer Genome Atlas | Glioblastoma Multiforme | LOC388789 | 0.25 | 0.11 | lasso | 2 | 0.07 | 3.4e-03 | -5.4 | 5.5 | 5.0e-08 | -1.00 | 0.00 | 0.85 | FALSE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RBBP9 | 0.10 | 0.08 | lasso | 2 | 0.07 | 5.9e-04 | -5.4 | 5.2 | 1.8e-07 | -0.95 | 0.00 | 0.96 | FALSE |