TWAS
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Neuroticism
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chr2:147,993,969-149,475,737
Best TWAS P=1.69e-15 · Best GWAS P=3.67e-17 conditioned to 0.0879
148M
148.2M
148.4M
148.6M
148.8M
149M
149.2M
149.4M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Brain Lower Grade Glioma
ORC4L
0.06
0.01
blup
37
0.03
0.00016
8.1
8.0
1.7e-15
0.84
0.01
0.97
TRUE
1
GTEx
Breast Mammary Tissue (Female)
ORC4
0.12
0.00
lasso
4
0.00
0.23200
7.9
-7.9
2.1e-15
-0.89
0.04
0.33
TRUE
2
The Cancer Genome Atlas
Bladder Urothelial Carcinoma
ORC4L
0.07
0.04
blup
37
0.03
0.00061
-5.7
7.1
9.5e-13
0.69
0.05
0.35
FALSE