TWAS hub - ORC4L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0650	0.0360	2.5e-03	0.037	0.035	0.029	NA	0.033	4.2e-04	6.1e-04	1.6e-03	NA	7.4e-04
2	TCGA	Breast Invasive Carcinoma	0.0437	0.0268	1.1e-05	0.027	0.029	0.031	NA	0.029	2.5e-06	1.3e-06	5.4e-07	NA	1.2e-06
3	TCGA	Brain Lower Grade Glioma	0.0646	0.0357	9.8e-05	0.009	0.031	0.016	NA	0.019	2.7e-02	1.6e-04	5.0e-03	NA	2.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Neuroticism	15.9	38.4	63.4	7.1	-0.8	8.0
Neuroticism (Nagel 2018)	14.8	34.8	55.7	7.0	-0.4	7.5
Neuroticism score	14.4	29.9	49.3	6.3	-0.5	7.0
Worry (Nagel 2018)	13.4	28.2	43.6	6.4	0.9	6.6
Nervous feelings	11.1	20.7	31.0	5.5	0.8	5.6
Loneliness, isolation	10.5	14.5	22.2	4.5	-0.9	4.7
Frequency of tiredness / lethargy in last 2 weeks	10.4	17.0	25.0	5.0	1.1	5.0
Tense / ‘highly strung’	9.7	16.0	25.5	4.7	0.6	5.1
Sensitivity / hurt feelings	8.7	14.9	25.0	4.3	-1.0	5.0
Fed-up feelings	8.7	15.8	25.9	4.6	-0.7	5.1
Irritability	8.7	14.8	22.5	4.6	0.6	4.7
Depressed Affect (Nagel 2018)	8.6	18.0	29.0	5.0	-0.6	5.4
Miserableness	8.4	14.5	24.1	4.3	-1.0	4.9
Worrier / anxious feelings	7.9	14.8	21.9	4.7	1.0	4.7
Supplements: Glucosamine	6.5	8.5	9.6	-3.1	-2.7	-2.9
Tinnitus: Yes, but not now, but have in the past	6.0	6.4	9.3	2.6	3.1	1.7
Frequency of tenseness / restlessness in last 2 weeks	5.9	9.1	14.0	3.6	-0.8	3.7
Neuroticism (2016)	5.7	8.2	14.1	3.2	-0.3	3.7
Depression (Nagel 2018)	5.2	7.9	12.3	3.1	-1.3	3.5
Qualifications: None of the above	4.9	10.5	14.1	3.8	2.5	3.4
Guilty feelings	4.7	7.1	10.6	3.1	1.0	3.3
Pack years adult smoking proportion	4.6	7.1	10.5	3.2	-0.8	3.2
Pack years of smoking	4.4	6.5	10.0	3.2	-0.5	3.0
Number of treatments/medications taken	4.3	7.7	12.4	2.8	3.5	1.6
Friendships satisfaction	4.3	5.3	6.8	1.7	-2.6	2.5
Family relationship satisfaction	4.2	5.2	8.4	2.4	-1.1	2.9
Exposure to tobacco smoke outside home	4.0	5.3	5.8	2.4	2.4	2.1
HbA1C	3.9	4.3	6.6	2.0	2.6	1.5
Prospective memory result	3.9	4.8	5.3	2.3	2.1	2.2
Mood swings	3.9	7.0	10.8	3.2	0.3	3.3
Fasting Glucose	3.8	4.6	6.0	2.4	-1.4	2.4
Supplements: Calcium	3.8	4.1	9.2	-1.5	-3.0	-1.0
Diastolic blood pressure, automated reading	3.7	11.4	27.6	2.3	5.3	1.1
Prostate Cancer	3.6	5.1	5.5	-2.3	-2.2	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	3.6	4.7	7.8	2.4	-0.9	2.8
Long-standing illness, disability or infirmity	3.5	5.4	6.9	2.5	2.6	1.7
Alzheimer’s Disease (in mother)	3.4	3.9	6.2	-2.5	-0.6	-2.3
Stomach or abdominal pain in last month	3.4	4.2	6.3	2.5	0.2	2.5
Worry too long after embarrassment	3.3	5.5	9.2	2.6	-0.8	3.0
Financial situation satisfaction	3.3	4.1	6.5	2.5	1.3	2.0
Type 2 Diabetes (T2D) (2012)	3.2	3.7	5.4	2.3	1.3	2.0
Bilateral oophorectomy (both ovaries removed)	3.2	3.7	4.3	2.1	1.9	1.8
Pulse rate, automated reading	3.2	10.5	16.6	3.8	0.7	4.1
Suffer from ‘nerves’	3.2	5.1	8.3	2.6	-0.1	2.9
Unable to work because of sickness or disability	3.2	4.1	6.5	2.6	0.0	2.4
Frequency of depressed mood in last 2 weeks	3.1	4.3	6.9	2.4	-0.3	2.6
Qualifications: College or University degree	3.1	9.8	11.5	-3.2	-3.4	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.1	3.6	5.4	2.3	1.0	2.1
Alcohol drinker status: Never	3.1	3.7	5.7	2.4	1.2	2.0
Systolic Blood Pressure	3.0	14.9	20.8	4.6	2.6	4.1
Taking other prescription medications	3.0	4.7	6.1	2.3	2.5	1.6
Mineral and other dietary supplements	2.9	3.9	6.8	1.8	2.6	1.3
Number of self-reported non-cancer illnesses	2.9	5.0	7.3	2.7	2.0	1.9
Vitamin and mineral supplements	2.8	3.8	7.8	1.7	2.8	0.7
Mouth/teeth dental problems	2.8	4.3	11.7	-0.4	3.4	-1.1
Headache pain in last month	2.8	4.9	6.0	2.5	2.1	2.0
Systolic blood pressure, automated reading	2.7	8.0	11.2	3.4	2.3	2.7
Commuting to job workplace: Cycle	2.7	3.3	5.2	-2.3	-0.5	-2.1
Falls in the last year	2.6	3.6	8.3	1.3	2.9	0.8
Alcohol intake frequency.	2.6	6.0	9.4	3.1	0.2	2.9
Intelligence (Savage-Jansen 2018)	2.5	7.7	10.6	-3.2	-1.6	-3.1
Hair/balding pattern: Pattern 3	2.5	3.8	5.1	1.9	2.3	1.6
Medication: Omeprazole	2.5	2.9	5.1	2.3	0.4	1.9
Vascular/heart problems diagnosed by doctor	2.5	6.8	9.7	-2.6	-3.1	-1.9
Forced vital capacity (FVC)	2.4	9.4	13.5	-3.1	-3.7	-2.2
Multivitamins +/- minerals	2.3	2.9	5.4	-1.6	-2.3	-0.8
Pulse rate	2.3	3.9	4.8	2.2	1.6	2.1
Hypertension (Self-reported)	2.3	6.3	7.8	2.6	2.8	2.1
Supplements: Fish oil (including cod liver oil)	2.3	3.0	4.7	-2.2	-1.0	-1.8
Major Depression (MDD)	2.2	2.7	4.1	1.6	2.0	1.2
Triglycerides	2.2	3.6	5.3	2.2	-0.8	2.3
Pulse wave Arterial Stiffness index	2.2	2.6	6.3	0.4	-2.5	1.1
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	4.2	2.1	1.2	1.6
Schizophrenia (2018)	2.1	4.4	6.7	2.6	1.2	2.2
HDL Cholesterol	2.1	3.5	5.6	-2.4	0.0	-2.2
Supplements: Zinc	2.1	2.3	3.5	1.8	0.5	1.9
Standing height	2.1	20.6	29.4	-4.5	-5.4	-3.5
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	4.7	-2.2	-1.3	-1.9
Health satisfaction	2.1	2.7	4.0	2.0	0.6	1.9
Overall health rating	2.1	4.4	6.7	2.6	0.2	2.6
Average weekly red wine intake	2.1	3.0	5.1	-1.8	0.8	-2.3
Medication: Bendroflumethiazide	2.1	3.2	7.9	1.1	2.8	0.8
Blood Eosinophil Count	2.0	15.3	21.3	-3.4	3.6	-4.6
Average weekly spirits intake	2.0	2.4	3.1	-1.8	-1.4	-1.5
High blood pressure	2.0	5.5	7.9	2.3	2.8	1.8
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.2	8.5	-1.8	-2.9	-1.0
Irritable Bowel Disease (IBD)	1.9	4.6	6.2	1.9	-2.0	2.5
Medication: Cholesterol lowering	1.9	2.9	6.4	-0.3	2.5	-1.5
Loud music exposure frequency	1.9	2.1	3.2	1.8	-0.0	1.7
Medication for pain relief, constipation, heartburn	1.9	3.2	5.2	-2.0	-2.3	-0.7
Heart disease (mother)	1.9	2.3	6.5	0.6	2.5	0.2
Alcohol drinker status: Previous	1.9	2.2	3.3	1.8	0.5	1.7
Ulcerative Colitis (UC)	1.8	3.4	4.2	1.4	-2.0	2.0
Breast Cancer	1.8	4.3	6.7	-2.4	0.4	-2.6
Age at First Birth	1.8	2.6	3.6	-1.9	-1.3	-1.5
Schizophrenia (2014)	1.8	4.0	5.8	2.4	1.5	1.9
Ulcerative Colitis	1.8	2.7	6.2	0.7	-2.5	1.2
Exposure to tobacco smoke at home	1.8	2.0	2.3	-1.2	1.5	-1.5
Pulse wave peak to peak time	1.8	2.1	3.9	-0.7	2.0	-1.3
Smoking status: Previous	1.8	2.7	4.1	-2.0	-0.2	-2.0
Chronotype (morning person)	1.7	3.9	7.5	1.8	2.7	1.1
Current tobacco smoking	1.7	2.7	4.3	1.5	-1.2	2.1
Leg fat-free mass (right)	1.7	9.2	12.2	-3.5	-3.0	-2.6
Leg predicted mass (right)	1.7	9.1	12.0	-3.5	-2.9	-2.6
Bipolar Disorder or Schizophrenia	1.6	3.9	6.0	2.4	1.2	2.0
Lupus	1.6	2.4	3.4	1.8	-0.7	1.9
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.6	1.9	0.3	1.4
Depression (self-reported)	1.6	1.9	3.6	-0.9	1.9	-1.1
Gout (self-reported)	1.6	2.2	4.0	-0.8	2.0	-1.3
Forced vital capacity (FVC), Best measure	1.6	5.7	9.2	-2.4	-3.0	-1.5
Shortness of breath walking on level ground	1.6	1.8	2.7	1.3	1.6	1.1
Medication: Blood pressure	1.6	2.9	4.4	1.7	2.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	5.0	-2.2	-0.1	-2.2
Basal cell carcinoma (self-reported)	1.6	1.9	2.4	-1.4	-1.5	-1.0
Hand grip strength (right)	1.5	4.1	6.6	-2.6	-0.4	-2.4
Average weekly fortified wine intake	1.5	1.8	2.8	1.7	0.6	1.5
High blood pressure (mother)	1.5	2.1	3.3	1.7	0.3	1.8
Happiness	1.5	1.8	3.2	1.3	-0.6	1.8
Mouth/teeth dental problems: Dentures	1.5	2.5	3.1	1.5	-1.5	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	3.4	1.3	1.8	0.9
Illnesses of siblings: Diabetes	1.5	1.8	3.0	1.7	0.5	1.4
Myopia	1.5	2.1	3.3	1.5	-0.8	1.8
Cardiovascular Disease	1.4	4.6	9.5	1.8	3.1	1.1
Diabetes (mother)	1.4	1.8	2.9	1.7	1.0	1.2
Diabetes (self-reported)	1.4	2.1	3.7	1.9	0.3	1.6
Forced expiratory volume in 1-second (FEV1)	1.4	4.9	6.7	-2.3	-2.6	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	2.6	-1.4	-0.8	-1.6
Smoking status: Current	1.4	2.3	3.6	1.2	-1.3	1.9
Height	1.3	25.0	28.7	-5.4	-5.1	-4.5
Leg fat-free mass (left)	1.3	6.9	9.5	-3.1	-2.5	-2.3
Leg predicted mass (left)	1.3	6.9	9.4	-3.1	-2.5	-2.3
Hearing difficulty/problems with background noise	1.3	2.1	3.8	1.4	2.0	0.8
Trunk fat-free mass	1.3	7.7	10.4	-2.9	-3.2	-2.1
Trunk predicted mass	1.3	7.6	10.5	-2.9	-3.2	-2.0
Medication: Paracetamol	1.3	2.2	3.4	1.6	1.9	0.9
Emphysema/chronic bronchitis	1.3	1.5	2.0	1.4	1.2	1.0
Whole body fat-free mass	1.3	7.3	8.9	-3.0	-2.9	-2.1
Diabetes diagnosed by doctor	1.3	2.1	3.8	1.9	0.4	1.6
Back pain experienced in last month	1.3	1.9	2.8	1.4	1.7	0.9
Whole body water mass	1.3	7.4	9.1	-3.0	-2.9	-2.2
Basal metabolic rate	1.3	7.1	9.3	-3.0	-2.6	-2.2
Breastfed as a baby	1.2	1.5	2.7	-0.7	1.6	-1.2
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.7	-1.1	-2.2	-0.3
Migraine (self-reported)	1.2	1.5	2.8	1.1	1.7	0.8
Average weekly champagne plus white wine intake	1.2	1.6	2.6	-1.5	-0.3	-1.6
Reaction Time	1.1	2.1	6.3	0.2	2.5	-0.2
Medication for hormone replacement therapy	1.1	1.2	1.8	1.3	0.3	1.3
Severe depression (siblings)	1.1	1.2	2.6	-1.0	0.3	-1.6
Age when periods started (menarche)	1.1	2.6	3.6	-1.9	-1.8	-1.1
Number of incorrect matches in round	1.1	1.8	4.7	0.1	2.2	-0.9
Arm fat-free mass (left)	1.1	5.6	7.7	-2.8	-2.2	-2.1
Pain experienced in last month	1.1	1.8	2.9	-1.7	-1.0	-1.3
Schizophrenia vs Biploar Disorder	1.0	1.3	2.6	-0.6	1.6	-1.0
Verbal and Numeric Reasoning (VNR)	1.0	2.4	3.0	-1.7	-1.4	-1.5
Hand grip strength (left)	1.0	2.5	4.3	-2.1	-0.5	-1.7
Serious illness, injury or assault to yourself	1.0	1.2	2.1	-1.1	0.6	-1.5
Sitting height	1.0	7.1	12.0	-2.6	-3.5	-1.6
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	1.6	1.2	1.1	0.9
Weight	1.0	4.7	7.4	-2.7	-1.3	-2.2
Medication: Lansoprazole	1.0	1.2	2.2	1.5	0.0	1.1
Pulse wave reflection index	1.0	1.2	1.9	0.6	-1.4	1.2
Medication: Amlodipine	1.0	1.4	2.9	0.9	1.7	0.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	1.8	1.1	-0.8	1.4
Medication: Paracetamol	1.0	1.5	2.1	1.4	1.4	0.8
Arm predicted mass (left)	1.0	5.3	7.5	-2.7	-2.1	-2.0
Crohns Disease (2017)	0.9	1.9	2.6	1.2	-1.3	1.6
Ovarian Cancer	0.9	1.2	3.4	-0.4	1.8	-0.5
Blood Red Count	0.9	8.3	22.8	1.4	4.8	0.1
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.1	1.8	0.4	1.3
Hearing difficulty/problems: Yes	0.9	1.3	2.0	1.3	-0.6	1.4
Ever had hysterectomy (womb removed)	0.9	1.1	3.0	0.2	1.7	-0.4
Angina	0.9	1.1	2.0	1.4	-0.3	1.2
Qualifications: CSEs or equivalent	0.9	1.2	1.4	1.1	0.9	1.2
Fluid intelligence score	0.9	1.8	2.4	-1.4	-1.6	-1.0
Illnesses of mother	0.9	1.1	1.8	-1.0	-1.3	-0.6
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.6	-1.3	0.5	-1.2
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.0	-1.1	0.7	-1.4
Mean time to correctly identify matches	0.9	1.7	2.2	-1.0	1.5	-1.4
Osteoarthritis (self-reported)	0.9	1.1	2.1	1.5	-0.5	1.0
Illnesses of father: High blood pressure	0.9	1.1	2.9	0.6	1.7	0.4
Primary Biliary Cirrhosis	0.8	1.1	1.4	-1.2	0.7	-1.2
Heel T-Score	0.8	6.2	7.5	2.7	2.5	2.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.4	1.2	0.2	1.2
Hair/balding pattern: Pattern 2	0.8	1.1	1.7	-1.2	-0.4	-1.3
Illnesses of siblings	0.8	1.2	1.6	-1.1	-1.3	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.2	-1.1	-0.8	-0.9
Peak expiratory flow (PEF)	0.8	1.9	3.4	-1.8	-0.3	-1.5
Comparative height size at age 10	0.8	4.3	9.7	-1.6	-3.1	-0.9
Medication: Aspirin	0.8	1.1	3.0	0.5	1.7	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.5	1.0	-0.6	1.2
Medication: Aspirin	0.8	1.1	2.8	0.6	1.7	-0.2
Ever smoked	0.8	1.4	3.5	-0.8	-1.9	-0.4
Rheumatoid Arthritis	0.7	0.9	1.2	1.1	-0.6	1.1
Lung FEV1/FVC ratio	0.7	3.4	9.5	0.8	3.1	0.3
Medication: Levothyroxine sodium	0.7	1.1	1.4	-0.8	1.1	-1.2
Hip circumference	0.7	3.2	4.5	-2.1	-1.3	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	3.1	-1.8	-1.6	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.9	0.2	1.7	-0.3
Birth weight of first child	0.7	1.2	1.9	-1.2	-0.5	-1.4
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.1	0.3	-1.5	0.7
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.9	0.1	2.0	-0.5
Birth weight	0.7	1.5	2.5	-1.1	-1.6	-0.9
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.1	0.6	1.5	0.1
Medication: Allopurinol	0.7	0.9	1.4	-0.7	1.2	-0.9
Arm predicted mass (right)	0.7	3.7	5.1	-2.2	-2.0	-1.4
Had major operations	0.7	0.9	1.9	-0.8	0.0	-1.4
Illnesses of father: None of the above (group 1)	0.7	0.9	1.1	1.0	1.1	0.7
Medication: Atorvastatin	0.7	0.9	1.7	-1.0	-0.1	-1.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	0.9	0.8	-0.9	0.9
Alzheimer’s Disease (including proxy)	0.6	0.9	1.3	-1.0	0.6	-1.1
Hypothyroidism (self reported)	0.6	1.4	4.0	0.2	2.0	-0.2
Respiratory disease	0.6	1.4	2.6	1.6	0.6	1.1
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.0	0.7	1.7	0.4
Trunk fat mass	0.6	2.6	4.0	-2.0	0.0	-1.9
Alcohol usually taken with meals	0.6	0.9	1.4	-0.7	0.9	-1.2
Allergy	0.6	1.3	3.4	-0.7	-1.9	-0.1
Father’s age at death	0.6	0.8	0.9	-0.9	-0.9	-0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.8	-1.0	-1.7	-0.5
Arm fat mass (right)	0.6	2.4	3.6	-1.9	0.1	-1.9
Glaucoma (self-reported)	0.6	0.7	1.5	-0.6	-1.2	-0.3
Arm fat-free mass (right)	0.6	3.1	4.2	-2.0	-1.9	-1.2
Angina (self-reported)	0.6	0.8	1.4	1.2	-0.4	0.9
Wears glasses or contact lenses	0.6	0.7	1.1	-1.0	-0.5	-0.9
Medication: Blood pressure	0.6	1.1	1.3	1.1	1.0	1.0
Risk taking	0.6	0.8	1.2	-1.1	-0.9	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.1	-0.8	-1.1	-0.7
Coronary Artery Disease (CAD)	0.5	0.6	1.6	-0.1	1.3	-0.5
Waist Hip Ratio (WHR)	0.5	2.1	3.5	1.3	1.9	1.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.8	0.9	0.8	0.7
Impedance of leg (right)	0.5	2.3	3.9	2.0	0.7	1.6
Financial difficulties in last 2 years	0.5	0.7	1.2	-1.1	0.1	-1.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.0	-0.9	-0.5	-1.0
Medication: Simvastatin	0.5	0.8	2.0	0.5	1.4	-0.3
Whole body fat mass	0.5	2.2	3.3	-1.8	0.1	-1.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	1.0	0.3	0.9
Qualifications: nursing, teaching	0.5	0.8	1.5	-0.5	1.2	-0.9
Arm fat mass (left)	0.5	2.1	3.2	-1.8	0.0	-1.8
Eye problems/disorders: Glaucoma	0.5	0.6	0.9	-1.0	-0.0	-0.9
Number of operations (self-reported)	0.5	0.8	1.6	1.2	0.5	0.7
Body Mass Index (BMI) (2010)	0.4	0.5	1.4	-0.1	1.2	-0.4
BMI	0.4	2.5	4.0	-2.0	-0.8	-1.7
Tanning	0.4	4.8	7.4	-2.7	-0.8	-2.5
Trunk fat percentage	0.4	1.6	2.4	-1.3	0.8	-1.5
Maternal smoking around birth	0.4	0.6	0.9	-1.0	0.5	-0.7
Past tobacco smoking	0.4	0.8	1.1	1.0	0.8	0.8
Had menopause	0.4	0.5	0.8	-0.8	-0.4	-0.9
Blood clot in the leg (DVT)	0.4	0.5	0.9	-0.7	-0.9	-0.5
Leg fat percentage (right)	0.4	1.4	3.9	0.5	2.0	0.2
Comparative body size at age 10	0.4	1.2	1.8	-1.3	-1.2	-0.6
Wheeze or whistling in the chest in last year	0.4	0.7	1.5	1.2	0.6	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.6	0.6	0.5	0.8
Medication: Seretide 50 evohaler	0.4	0.4	1.0	0.1	1.0	-0.5
Number of full sisters	0.4	0.5	1.3	0.1	1.1	-0.3
Ever had bowel cancer screening	0.4	0.5	1.1	0.5	-1.0	0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.0	0.2	-1.4	0.4
Medication for cholesterol	0.4	0.7	1.0	-1.0	-0.7	-0.7
Medication: Gliclazide	0.4	0.4	0.9	0.1	0.9	-0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.2	0.4	1.1	-0.2
Bipolar Disorder (2011)	0.3	0.3	0.4	-0.5	-0.3	-0.6
Smoking Status	0.3	0.6	1.2	-0.7	-1.1	-0.5
Lung FVC	0.3	1.5	2.5	-1.6	-0.7	-1.2
Diabetes (father)	0.3	0.4	0.7	0.6	-0.3	0.8
Impedance of leg (left)	0.3	1.5	2.3	1.5	0.7	1.3
Waist circumference	0.3	1.2	1.8	-1.3	0.2	-1.3
Heart attack	0.3	0.4	1.0	0.4	1.0	-0.2
Arm fat percentage (right)	0.3	1.3	1.9	-1.1	0.8	-1.4
Hair/balding pattern: Pattern 4	0.3	0.6	1.0	0.7	1.0	0.5
Body fat percentage	0.3	1.1	1.3	-0.9	1.1	-1.2
Number of full brothers	0.3	0.3	0.5	0.7	-0.2	0.7
Chest pain or discomfort	0.3	0.4	0.7	0.9	0.1	0.6
Age at last live birth	0.3	0.4	0.7	-0.3	0.9	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	0.3	0.9	0.1
Breast cancer (self-reported)	0.3	0.4	0.5	0.5	-0.7	0.7
Hearing aid user	0.3	0.4	0.6	0.7	0.8	0.2
Commuting to job workplace: Public transport	0.3	0.4	1.2	0.2	1.1	0.0
High cholesterol (Self-reported)	0.3	0.6	1.4	0.6	1.2	-0.1
Leg fat percentage (left)	0.3	1.1	3.4	-0.0	1.9	-0.2
Leg fat mass (left)	0.3	1.1	1.5	-1.2	0.8	-1.1
Bipolar Disorder (2018)	0.2	0.4	0.5	0.7	0.6	0.5
Crohns Disease (2012)	0.2	0.3	1.0	-0.1	-1.0	-0.0
Blood White Count	0.2	1.7	4.9	0.6	2.2	0.1
Townsend deprivation index at recruitment	0.2	0.3	0.7	-0.4	0.8	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.4	0.6	0.7	0.5
Body mass index (BMI)	0.2	0.9	1.3	-0.8	1.1	-0.8
Medication: Ramipril	0.2	0.2	0.6	-0.2	0.2	-0.8
Time employed in main current job	0.2	0.3	0.3	0.5	0.5	0.5
Noisy workplace	0.2	0.2	0.4	0.6	0.3	0.4
Length of working week for main job	0.2	0.3	0.7	0.2	0.8	0.2
Age at first live birth	0.2	0.3	0.5	-0.6	-0.2	-0.7
Eye problems/disorders: None of the above	0.2	0.3	0.6	-0.3	-0.8	-0.1
Medication: Ibuprofen	0.2	0.2	0.6	-0.2	-0.8	-0.2
Leg fat mass (right)	0.2	0.7	0.8	-0.9	0.8	-0.8
Leg pain on walking	0.2	0.3	0.3	0.5	-0.4	0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.0	0.6	-0.4
Arm fat percentage (left)	0.2	0.8	1.2	-0.9	0.8	-1.1
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	0.1	0.8	0.3
Eye problems/disorders: Cataract	0.2	0.2	0.3	0.4	0.1	0.6
Asthma (self-reported)	0.2	0.3	0.6	0.8	0.5	0.4
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.3	0.7	-0.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.5	0.5	-0.1	0.7
Medication: Lisinopril	0.2	0.2	0.7	-0.0	0.8	-0.1
Ever depressed for a whole week	0.2	0.3	0.5	-0.4	0.3	-0.7
Cholesterol lowering medication	0.2	0.3	0.4	0.6	0.6	0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.2	0.5	0.2
Mean Putamen Volume	0.1	0.1	0.2	-0.1	0.4	-0.2
Allergy or Eczema	0.1	0.3	0.5	-0.4	0.4	-0.7
Hair Pigment	0.1	2.4	3.1	1.8	1.1	1.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	0.7	0.2	-0.1
Medication: Co-codamol	0.1	0.1	0.1	-0.2	-0.2	-0.3
Medication: Metformin	0.1	0.2	0.3	0.5	0.3	0.4
Medication: Atenolol	0.1	0.2	0.4	0.3	0.6	0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.0	0.2	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	0.6	-0.1	0.7
Pain all over the body in last month	0.1	0.2	0.3	0.2	-0.6	0.4
Asthma	0.1	0.2	0.4	0.7	0.3	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	0.3	0.4	-0.1
Lung cancer (father)	0.1	0.1	0.1	-0.2	-0.2	-0.4
Impedance of arm (left)	0.1	0.3	0.5	-0.1	-0.7	-0.5
High blood pressure (siblings)	0.1	0.2	0.2	0.4	0.5	0.4
Number of children fathered	0.1	0.1	0.1	-0.4	-0.2	-0.2
Neck or shoulder pain in last month	0.1	0.1	0.2	0.4	0.3	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.0	-0.5	-0.1
Supplements: Vitamin C	0.1	0.1	0.2	-0.4	-0.1	-0.4
Knee pain experienced in last month	0.1	0.2	0.2	-0.4	-0.5	-0.4
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.5	0.1	-0.4
Osteoporosis (self-reported)	0.1	0.1	0.2	-0.3	-0.4	-0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.3	-0.2	-0.5	-0.4
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.4	0.3	0.1
Age started oral contraceptive pill	0.1	0.1	0.2	0.4	-0.1	0.2
LDL Cholesterol	0.0	0.1	0.1	0.2	-0.3	0.1
Blood Platelet Count	0.0	0.2	0.3	-0.4	0.1	-0.5
Relative age of first facial hair	0.0	0.0	0.1	-0.2	0.2	-0.1
Relative age voice broke	0.0	0.0	0.0	-0.0	0.0	-0.0
Had other major operations	0.0	0.0	0.0	-0.1	-0.1	-0.1
Impedance of arm (right)	0.0	0.2	0.4	-0.2	-0.3	-0.7
Alcohol intake versus 10 years previously	0.0	0.1	0.2	0.1	-0.4	0.0
Number of live births	0.0	0.0	0.0	0.1	-0.0	0.1
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.2	-0.3	0.0
Mother’s age at death	0.0	0.0	0.0	-0.1	-0.1	-0.1
Fractured/broken bones in last 5 years	0.0	0.0	0.1	-0.2	-0.0	-0.2
Heart disease (siblings)	0.0	0.0	0.1	0.2	0.0	0.1
Impedance of whole body	0.0	0.1	0.2	0.4	0.1	-0.0

Hub : Genes

ORC4L

Models

Trait associations