TWAS
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Models
Genes
Traits
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chr7:116,660,803-118,518,479
Best TWAS P=7.85e-14 · Best GWAS P=5.02e-14 conditioned to 1
117M
117.5M
118M
118.5M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Skin Sun Exposed Lower leg
CTTNBP2
0.14
0.10
lasso
2
0.08
2.4e-07
-7.5
-7.5
7.9e-14
1.00
0.00
1.00
TRUE
2
GTEx
Nerve Tibial
NAA38
0.13
0.14
lasso
11
0.10
2.9e-07
-5.1
5.2
2.6e-07
-0.19
1.00
0.00
TRUE
1
GTEx
Cells Transformed fibroblasts
CTTNBP2
0.12
0.08
lasso
7
0.09
6.0e-07
-7.5
-7.1
1.0e-12
0.92
0.00
1.00
FALSE
5
The Cancer Genome Atlas
Breast Invasive Carcinoma
CTTNBP2
0.03
0.01
blup
90
0.01
1.0e-02
-6.6
-6.2
6.2e-10
0.66
0.06
0.74
FALSE
4
GTEx
Testis
CTTNBP2
0.19
0.10
lasso
2
0.07
7.0e-04
-5.2
-5.5
4.3e-08
0.56
0.13
0.15
FALSE