TWAS
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chr8:26,648,746-28,100,234
Best TWAS P=5.96e-20 · Best GWAS P=9.94e-24 conditioned to 0.00019
26.6M
26.8M
27M
27.2M
27.4M
27.6M
27.8M
28M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
CLU
0.04
0.00
blup
66
0.01
1.1e-02
-7.6
9.1
6.0e-20
-0.63
0.01
0.60
TRUE
3
The Cancer Genome Atlas
Glioblastoma Multiforme
EPHX2
0.15
0.12
lasso
7
0.12
2.0e-04
-9.8
-8.2
3.1e-16
0.77
0.05
0.79
TRUE
1
GTEx
Thyroid
EPHX2
0.17
0.08
lasso
6
0.07
3.1e-06
-4.3
-6.4
1.2e-10
0.60
0.30
0.68
FALSE
2
The Cancer Genome Atlas
Colon Adenocarcinoma
EPHX2
0.09
0.00
blup
124
0.02
1.6e-02
-9.8
-5.3
1.1e-07
0.48
0.03
0.67
FALSE