Hub : Genes

NAA38

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0670 0.0250 1.6e-07 0.076 0.055 0.059 0.054 0.062 1.3e-09 3.1e-07 1.0e-07 3.5e-07 4.4e-08
2 GTEx Brain Cerebellum 0.1320 0.0650 2.4e-03 0.206 NA 0.111 NA 0.156 1.0e-06 NA 3.7e-04 NA 2.3e-05
3 GTEx Breast Mammary Tissue 0.1140 0.0520 6.2e-03 0.083 NA 0.018 NA 0.032 4.5e-05 NA 3.9e-02 NA 8.7e-03
4 GTEx Breast Mammary Tissue (Male) 0.1311 0.0903 9.2e-02 0.005 NA 0.015 NA 0.021 2.4e-01 NA 1.4e-01 NA 1.1e-01
5 GTEx Breast Mammary Tissue (Female) 0.0135 0.0520 4.2e-01 0.000 NA -0.005 NA -0.008 3.3e-01 NA 4.7e-01 NA 6.3e-01
6 GTEx Cells Transformed fibroblasts 0.0710 0.0300 2.1e-05 0.063 NA 0.061 NA 0.069 1.7e-05 NA 2.3e-05 NA 6.9e-06
7 GTEx Nerve Tibial 0.1254 0.0463 1.2e-06 0.136 NA 0.045 NA 0.096 7.4e-10 NA 3.9e-04 NA 2.9e-07
8 GTEx Testis 0.0800 0.0410 7.9e-03 0.004 NA -0.005 NA -0.003 2.0e-01 NA 6.1e-01 NA 4.4e-01
9 GTEx Thyroid 0.0500 0.0260 2.5e-03 0.026 NA 0.010 NA 0.021 4.3e-03 NA 5.1e-02 NA 9.1e-03
10 ROSMAP Brain Pre-frontal Cortex 0.0577 0.0220 4.6e-08 0.074 0.057 0.072 0.059 0.078 7.8e-10 8.0e-08 1.6e-09 4.4e-08 3.1e-10
11 TCGA Cervical Squamous Cell Carcinoma 0.0960 0.0530 1.9e-03 0.076 0.036 0.028 NA 0.047 1.3e-04 6.9e-03 1.5e-02 NA 2.4e-03
12 TCGA Colon Adenocarcinoma 0.0610 0.0350 1.8e-03 0.046 0.033 0.043 NA 0.036 1.1e-03 4.9e-03 1.6e-03 NA 3.7e-03
13 TCGA Head and Neck Squamous Cell Carcinoma 0.0702 0.0392 5.7e-07 0.049 0.035 0.036 NA 0.035 3.3e-06 7.2e-05 6.4e-05 NA 7.0e-05
14 TCGA Kidney Renal Clear Cell Carcinoma 0.0445 0.0250 1.4e-04 0.032 0.039 0.036 NA 0.031 1.3e-04 2.7e-05 5.4e-05 NA 1.8e-04
15 TCGA Kidney Renal Papillary Cell Carcinoma 0.1620 0.0780 4.7e-06 0.083 0.074 0.066 NA 0.082 1.7e-05 5.0e-05 1.2e-04 NA 2.0e-05
16 TCGA Ovarian Serous Cystadenocarcinoma 0.1380 0.1020 2.5e-04 0.052 0.049 0.048 NA 0.045 2.1e-04 3.0e-04 3.4e-04 NA 5.0e-04
17 TCGA Thyroid Carcinoma 0.0630 0.0320 3.5e-05 0.053 0.039 0.044 NA 0.051 6.9e-06 9.7e-05 4.2e-05 NA 9.8e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 0.2 0.3 1.5 -0.2 0.0 1.2 1.2 0.0 0.3 0.4 -0.9 0.2 0.4 -0.3 -0.3 -0.7 0.0 -0.3 -0.1 -0.3
Bipolar Disorder or Schizophrenia 0.3 0.7 2.3 0.6 0.1 1.3 1.5 0.0 -0.1 -0.6 -1.0 -0.4 -0.4 -1.1 -1.0 -1.2 -0.5 -0.5 -0.9 -1.1
Depressed Affect (Nagel 2018) 0.2 0.5 2.8 0.1 -0.7 1.2 1.4 0.0 0.5 0.6 -1.7 -0.1 0.5 -0.0 -0.1 -0.1 -0.0 -0.6 -0.6 -0.1
Depression (Nagel 2018) 0.1 0.2 1.5 -0.6 -0.2 0.7 1.2 0.0 0.2 0.3 -0.9 -0.6 0.3 -0.0 -0.1 0.3 -0.0 -0.2 -0.2 -0.0
Intelligence (Savage-Jansen 2018) 1.1 3.4 6.2 1.9 -1.4 2.5 2.3 0.0 -0.9 -0.8 -2.4 -1.4 -1.0 -2.1 -2.2 -2.4 -1.3 -2.1 -2.2 -2.0
Neuroticism (Nagel 2018) 0.5 1.2 3.0 1.1 -1.2 1.4 1.4 0.0 -0.4 -0.4 -1.7 -1.3 -0.5 -0.9 -1.1 -0.8 -1.0 -1.3 -1.6 -1.2
Schizophrenia (2018) 0.3 0.6 1.6 0.7 0.2 0.7 0.9 0.0 -0.4 -1.1 -0.5 -0.7 -0.8 -1.1 -1.0 -0.8 -0.5 -0.4 -0.9 -1.3
Schizophrenia vs Biploar Disorder 0.2 0.2 1.7 -0.1 1.3 0.1 0.2 0.0 0.7 -0.0 -0.3 0.1 0.2 0.3 0.4 0.2 0.6 0.8 0.2 -0.0
Worry (Nagel 2018) 0.1 0.2 0.9 0.2 -0.4 0.3 0.6 0.0 -0.2 -0.3 -0.5 -0.9 -0.4 -0.4 -0.4 -0.1 -0.6 -0.5 -0.9 -0.5
Alzheimer’s Disease (in mother) 1.4 1.7 4.0 -2.0 1.1 -0.3 -0.1 0.0 1.3 1.3 0.1 1.7 1.4 1.6 1.6 1.5 1.2 1.4 1.2 1.5
Alzheimer’s Disease (in father) 2.4 2.6 5.0 1.1 -1.2 -2.0 -2.1 0.0 -2.2 -1.9 2.1 -1.9 -1.9 -1.1 -1.2 -1.0 -2.0 -1.6 -1.4 -1.0
Alzheimer’s Disease (including proxy) 0.2 0.3 1.7 -0.5 -0.1 -1.3 -1.2 0.0 -0.5 -0.4 1.0 0.1 -0.4 0.2 0.2 -0.0 -0.5 0.0 -0.2 0.2
Crohns Disease (2017) 0.5 1.0 2.7 0.7 -1.6 -0.8 -0.4 0.0 -1.2 -0.9 0.8 -1.5 -1.1 -0.8 -0.8 0.6 -1.2 -1.6 -0.9 -0.8
Irritable Bowel Disease (IBD) 1.5 3.6 7.0 1.9 -2.6 -1.1 -1.0 0.0 -2.4 -2.0 1.2 -2.4 -2.2 -1.9 -1.9 -0.5 -2.3 -2.5 -1.9 -1.9
Ulcerative Colitis (UC) 1.2 2.2 5.0 1.6 -2.2 -0.8 -0.8 0.0 -2.0 -1.5 0.9 -1.6 -1.7 -1.5 -1.5 -0.7 -1.8 -1.9 -1.4 -1.5
Major Depression (MDD) 6.5 7.9 12.4 -3.5 2.5 -0.1 0.4 0.0 3.1 3.4 -0.5 3.4 3.2 3.3 3.2 3.1 3.2 2.8 3.5 3.3
Reaction Time 0.3 0.6 1.6 -0.3 -0.2 1.2 1.0 0.0 1.0 1.0 -1.3 0.6 1.1 0.5 0.5 -0.0 0.9 0.4 0.3 0.5
Verbal and Numeric Reasoning (VNR) 1.0 2.4 4.1 2.0 -1.3 0.9 0.7 0.0 -1.4 -1.3 -0.9 -1.5 -1.5 -2.0 -2.0 -1.8 -1.6 -1.9 -1.9 -1.9
Breast Cancer 0.7 1.7 5.8 1.3 -2.4 -0.7 -1.1 0.0 -1.8 -1.2 0.8 -1.5 -1.4 -1.2 -1.2 -1.0 -1.4 -1.5 -1.1 -1.1
Ovarian Cancer 0.2 0.3 0.9 0.3 -0.3 -0.9 -0.9 0.0 -0.8 -0.5 0.7 -0.6 -0.7 -0.2 -0.2 0.8 -0.6 -0.3 -0.2 -0.2
Prostate Cancer 0.4 0.5 1.1 -1.1 0.5 -0.3 -0.4 0.0 0.7 1.0 0.3 0.7 0.8 1.0 0.9 0.8 0.9 0.4 0.8 1.0
Age at First Birth 0.2 0.2 0.6 -0.5 -0.2 -0.3 0.0 0.0 0.1 0.6 0.6 0.5 0.5 0.6 0.5 0.4 0.6 0.5 0.8 0.6
Bipolar Disorder (2011) 0.7 0.7 1.4 0.7 -1.0 1.2 1.2 0.0 -0.4 -0.4 -1.0 -0.3 -0.4 -1.0 -1.0 -1.2 -0.6 -1.0 -0.9 -0.8
Body Mass Index (BMI) (2010) 0.3 0.4 1.1 -0.1 0.3 0.8 0.3 0.0 0.9 1.0 -0.6 1.1 0.9 0.6 0.5 -0.2 0.8 0.4 0.3 0.5
Coronary Artery Disease (CAD) 0.1 0.2 0.4 -0.3 0.5 0.3 0.2 0.0 0.6 0.5 -0.4 0.5 0.5 0.4 0.4 0.2 0.4 0.3 0.2 0.2
Crohns Disease (2012) 1.0 1.6 3.7 1.2 -1.4 -0.5 -0.3 0.0 -1.5 -1.5 0.5 -1.9 -1.5 -1.4 -1.3 -0.1 -1.5 -1.7 -1.2 -1.4
Mean Putamen Volume 1.5 1.7 3.1 -1.4 1.1 0.3 0.3 0.0 1.7 1.5 -0.2 1.5 1.6 1.6 1.6 0.9 1.6 1.8 1.4 1.6
Fasting Glucose 0.1 0.2 1.0 -1.0 -0.3 0.2 0.6 0.0 -0.2 -0.2 -0.4 -0.2 -0.3 0.2 -0.1 -0.2 -0.5 -0.4 -0.4 0.0
HbA1C 0.8 0.9 4.0 1.6 0.5 -1.7 -2.0 0.0 -0.7 -0.7 1.5 -0.5 -0.5 -1.2 -0.4 -0.3 -0.3 0.4 -0.0 -0.0
HDL Cholesterol 0.1 0.2 0.8 0.3 -0.9 -0.5 -0.2 0.0 -0.6 -0.4 0.5 -0.4 -0.6 -0.4 -0.4 0.1 -0.6 -0.3 -0.2 -0.3
LDL Cholesterol 1.0 1.5 2.8 -1.2 1.7 -0.7 -0.5 0.0 1.4 1.1 0.6 1.0 1.3 1.4 1.4 1.6 1.3 1.6 1.4 1.5
Lupus 0.7 1.1 2.6 0.9 -0.1 -1.3 -1.2 0.0 -1.2 -1.6 1.4 -1.4 -1.5 -0.8 -0.8 -0.3 -1.4 -0.5 -0.9 -0.8
Neuroticism (2016) 1.0 1.4 5.2 -0.9 0.4 1.8 2.3 0.0 1.5 1.8 -1.9 0.9 1.5 0.5 0.5 0.0 0.8 0.2 0.2 0.6
Primary Biliary Cirrhosis 1.3 1.9 3.2 1.4 -1.5 -0.6 -0.3 0.0 -1.8 -1.7 0.6 -1.6 -1.7 -1.6 -1.6 -1.0 -1.8 -1.3 -1.5 -1.5
Rheumatoid Arthritis 0.6 0.9 1.4 -1.2 1.0 0.3 0.5 0.0 1.2 1.1 -0.4 1.1 1.1 1.0 1.0 0.8 1.2 1.2 1.0 0.9
Schizophrenia (2014) 0.5 1.1 2.9 0.9 -0.1 1.2 1.3 0.0 -0.3 -0.9 -1.0 -1.0 -0.7 -1.3 -1.3 -1.7 -0.7 -0.9 -1.4 -1.5
Triglycerides 2.6 4.2 7.7 -2.0 1.9 1.0 0.9 0.0 2.8 2.5 -1.1 2.5 2.8 2.2 2.2 1.8 2.5 2.2 2.3 1.9
Type 2 Diabetes (T2D) (2012) 1.1 1.2 2.2 -1.2 1.4 0.6 0.8 0.0 1.4 1.5 -0.7 1.3 1.4 1.1 1.0 0.9 1.3 1.0 1.1 1.1
Ulcerative Colitis 1.5 2.2 4.2 1.5 -1.7 -0.9 -0.9 0.0 -2.0 -1.8 1.0 -1.8 -1.9 -1.5 -1.5 -1.0 -1.9 -1.4 -1.5 -1.6
Blood Eosinophil Count 0.4 2.9 5.6 -1.4 1.4 1.0 0.8 0.0 2.4 2.1 -1.1 1.9 2.2 1.9 1.9 1.0 2.3 2.0 1.6 1.8
Blood Platelet Count 0.0 0.6 1.3 0.7 -0.7 -0.4 -0.1 0.0 -0.9 -0.9 0.1 -0.9 -1.0 -0.8 -0.8 -0.3 -1.1 -1.1 -0.8 -0.8
Blood Red Count 0.1 1.2 3.0 -1.3 0.9 -0.9 -1.0 0.0 0.6 0.8 1.0 1.0 0.9 1.3 1.2 1.7 1.1 1.2 1.4 1.3
Blood White Count 0.2 1.2 6.2 0.1 -0.3 2.2 2.3 0.0 1.0 0.9 -2.5 0.1 0.8 -0.1 -0.1 -0.7 0.4 -0.2 -0.5 -0.1
Heel T-Score 0.4 3.4 5.9 -2.2 1.4 1.6 2.1 0.0 2.3 2.4 -1.3 2.4 2.2 1.4 1.4 1.6 2.2 1.4 2.1 1.4
BMI 0.1 0.5 1.3 0.6 -1.0 0.4 0.5 0.0 -0.7 -0.3 -0.6 -0.5 -0.5 -0.7 -0.7 -0.9 -0.8 -1.1 -0.9 -0.7
Height 0.0 0.4 0.7 0.5 0.0 -0.3 -0.3 0.0 -0.8 -0.9 0.7 -0.5 -0.8 -0.8 -0.7 -0.5 -0.6 -0.7 -0.5 -0.7
Waist Hip Ratio (WHR) 0.4 1.7 3.2 -1.8 0.7 0.4 0.8 0.0 1.6 1.4 -0.8 1.8 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.4
Systolic Blood Pressure 0.0 0.2 0.6 0.7 -0.7 -0.4 -0.4 0.0 -0.6 -0.7 0.2 -0.7 -0.6 -0.4 -0.4 0.1 -0.5 -0.0 -0.4 -0.4
Smoking Status 6.2 14.8 26.5 -4.7 2.9 1.2 1.7 0.0 4.7 5.2 -2.0 4.8 5.1 4.4 4.3 2.9 4.4 3.5 3.8 4.7
Allergy or Eczema 0.1 0.4 1.9 0.6 -0.3 1.4 1.3 0.0 0.3 0.0 -1.3 -0.1 0.1 -0.5 -0.5 -0.5 0.1 -0.1 -0.2 -0.5
Cardiovascular Disease 0.1 0.2 0.9 -0.2 -0.4 1.0 1.0 0.0 0.5 0.7 -0.9 0.0 0.5 0.1 0.1 -0.3 0.2 0.1 -0.3 0.1
Hypothyroidism (self reported) 0.8 1.8 3.3 1.5 -1.4 -0.6 -0.6 0.0 -1.8 -1.6 0.8 -1.8 -1.6 -1.4 -1.5 -1.1 -1.4 -1.4 -1.3 -1.5
Respiratory disease 0.8 1.7 6.3 1.2 -0.8 2.5 2.2 0.0 0.5 0.2 -2.3 -0.8 0.1 -0.9 -0.9 -2.1 -0.0 -0.9 -1.4 -0.9
Type 2 Diabetes (T2D) (2018) 0.9 1.7 3.3 -1.0 1.4 0.8 0.7 0.0 1.8 1.6 -1.2 1.7 1.6 1.2 1.3 1.3 1.6 1.2 1.3 1.2
Lung FEV1/FVC ratio 0.6 3.0 5.1 -2.3 2.0 -1.7 -1.4 0.0 1.4 1.1 1.2 1.6 1.3 2.1 2.1 2.0 1.4 2.0 2.1 2.1
Lung FVC 0.3 1.3 2.7 1.0 -1.2 -0.9 -0.8 0.0 -1.6 -1.3 0.6 -1.3 -1.5 -1.2 -1.2 -0.5 -1.5 -1.2 -1.0 -1.1
Neuroticism 0.2 0.5 1.1 -0.6 0.8 0.6 0.6 0.0 1.0 1.0 -1.0 0.3 0.9 0.8 0.7 0.9 0.6 0.6 0.2 0.7
Chronotype (morning person) 0.6 1.5 3.7 -0.9 1.4 -0.9 -1.2 0.0 1.0 0.9 0.5 1.0 0.9 1.5 1.6 1.4 1.2 1.9 1.4 1.5
Hair Pigment 0.1 1.8 3.5 1.5 -1.8 1.2 1.3 0.0 -1.0 -0.9 -0.9 -1.2 -1.1 -1.7 -1.6 -1.1 -1.2 -1.9 -1.6 -1.6
Tanning 0.2 2.7 11.5 -1.2 1.3 -3.4 -3.2 0.0 -0.7 -0.6 3.2 0.7 -0.4 1.1 1.1 1.6 -0.0 1.0 1.4 1.1
Hand grip strength (left) 0.5 1.2 2.8 -1.4 0.8 -0.6 -0.5 0.0 0.9 0.9 0.5 1.3 0.9 1.2 1.2 1.6 1.1 1.3 1.7 1.2
Number of treatments/medications taken 1.2 2.2 4.9 1.4 -1.7 1.9 2.2 0.0 -0.7 -0.7 -1.9 -1.2 -0.8 -1.7 -1.7 -1.6 -1.2 -1.5 -1.7 -1.7
Average weekly spirits intake 0.3 0.4 1.2 0.4 -0.6 -0.8 -0.6 0.0 -0.9 -0.7 0.6 -0.2 -0.7 -0.5 -0.6 -0.2 -1.1 -0.7 -0.4 -0.4
Sensitivity / hurt feelings 0.9 1.5 3.6 0.6 -1.3 -1.9 -1.5 0.0 -1.9 -1.5 1.6 -1.4 -1.5 -0.7 -0.7 0.3 -1.6 -0.8 -0.7 -0.6
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.5 -0.5 -0.0 0.9 1.1 0.0 0.6 0.7 -1.2 -0.0 0.7 0.2 0.2 0.4 0.4 0.1 -0.1 0.3
Hearing difficulty/problems: Yes 1.3 1.9 4.4 1.7 -1.8 2.1 1.7 0.0 -0.3 -0.4 -1.8 -0.8 -0.5 -1.4 -1.4 -2.0 -0.6 -1.4 -1.5 -1.4
Relative age of first facial hair 0.0 0.0 0.1 0.4 -0.0 0.3 0.2 0.0 0.1 -0.2 -0.4 -0.1 -0.0 -0.1 -0.1 -0.3 0.1 0.2 -0.2 -0.2
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.9 -0.4 0.2 1.5 1.7 0.0 1.2 0.9 -1.5 0.7 1.0 0.3 0.3 -0.2 0.9 0.7 0.2 0.3
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.2 -0.1 -1.1 0.8 1.0 0.0 0.0 0.6 -0.8 0.1 0.4 -0.1 -0.1 -0.6 0.2 -0.4 0.0 0.1
Ever had hysterectomy (womb removed) 0.4 0.4 1.4 0.3 -0.9 1.2 1.0 0.0 0.2 0.9 -1.2 0.3 0.5 -0.1 -0.2 -0.8 0.1 -0.8 -0.5 -0.0
Systolic blood pressure, automated reading 0.1 0.3 0.8 0.5 -0.5 -0.4 -0.1 0.0 -0.7 -0.7 0.5 -0.9 -0.7 -0.6 -0.6 -0.1 -0.7 -0.6 -0.5 -0.6
Eye problems/disorders: Diabetes related eye disease 1.6 1.8 3.5 1.4 -1.9 0.9 1.0 0.0 -1.2 -1.4 -0.9 -1.2 -1.3 -1.8 -1.7 -1.2 -1.2 -1.3 -1.3 -1.8
Angina 4.5 5.9 10.3 2.4 -3.2 -0.3 -0.3 0.0 -2.9 -2.6 0.4 -3.0 -2.9 -2.8 -2.9 -1.9 -3.1 -2.9 -2.5 -2.8
Medication for hormone replacement therapy 1.1 1.2 2.0 1.3 -0.9 0.5 0.7 0.0 -1.0 -1.0 -0.6 -1.2 -1.1 -1.4 -1.4 -1.3 -1.2 -1.3 -1.4 -1.4
Vitamin and mineral supplements 1.5 2.0 4.0 2.0 -0.9 -0.2 -0.6 0.0 -1.7 -1.6 0.3 -1.4 -1.6 -1.6 -1.6 -1.8 -1.5 -1.4 -1.8 -1.6
Supplements: Zinc 2.3 2.5 4.7 -1.1 2.0 0.4 -0.0 0.0 2.1 1.6 -0.2 1.8 1.9 1.8 2.0 1.1 2.2 2.1 1.5 1.8
Medication: Co-codamol 0.9 1.0 3.9 0.1 -1.2 1.9 1.8 0.0 0.7 1.1 -2.0 0.8 0.9 -0.0 -0.0 -1.1 0.5 -0.4 -0.4 0.1
Medication: Metformin 0.8 1.1 6.1 0.6 -0.3 2.2 1.9 0.0 0.9 0.8 -2.5 0.5 0.6 -0.4 -0.3 -0.7 0.3 -0.4 -0.5 -0.4
Diabetes (father) 0.5 0.6 1.1 1.0 -0.5 0.6 0.4 0.0 -0.7 -0.6 -0.5 -0.4 -0.7 -1.0 -1.0 -0.9 -0.9 -1.1 -1.0 -1.1
Diabetes (mother) 0.9 1.1 2.1 -1.0 1.3 0.4 0.5 0.0 1.4 1.1 -0.7 1.0 1.2 1.1 1.2 0.8 1.4 1.3 1.1 1.1
Severe depression (siblings) 0.4 0.4 1.3 -0.4 0.7 0.9 1.1 0.0 0.9 0.7 -1.1 0.7 0.7 0.3 0.4 -0.1 0.7 0.3 0.1 0.4
Pack years adult smoking proportion 0.2 0.3 1.5 0.1 -0.3 0.9 1.0 0.0 0.2 0.1 -1.2 0.1 0.1 -0.4 -0.4 -0.6 -0.3 -0.1 -0.3 -0.4
Impedance of leg (right) 0.2 1.0 3.9 -0.6 1.1 -1.8 -2.0 0.0 -0.1 -0.3 1.7 0.3 -0.1 0.8 0.7 1.1 0.3 1.1 1.0 0.7
Leg fat-free mass (left) 0.1 0.4 1.2 -0.9 0.1 0.4 0.5 0.0 0.6 1.1 -0.3 0.9 0.9 0.6 0.6 0.4 0.6 0.0 0.5 0.7
Trunk fat percentage 0.4 1.8 4.5 1.3 -1.8 0.1 0.2 0.0 -1.6 -1.0 -0.2 -1.3 -1.3 -1.5 -1.6 -1.2 -1.6 -2.1 -1.6 -1.5
Hand grip strength (right) 0.6 1.5 3.7 -1.4 1.1 -1.4 -1.2 0.0 0.6 0.6 1.3 1.1 0.6 1.3 1.3 1.9 1.0 1.3 1.8 1.3
Townsend deprivation index at recruitment 2.2 3.1 6.3 -1.3 0.9 1.9 1.8 0.0 2.4 2.4 -2.5 2.5 2.4 1.5 1.5 0.5 1.9 1.5 0.9 1.5
Current tobacco smoking 3.5 5.7 10.3 -2.8 1.8 1.1 1.4 0.0 3.0 3.1 -1.7 3.1 3.2 2.6 2.5 1.7 2.6 2.2 2.4 2.7
Average weekly fortified wine intake 2.0 2.4 4.6 1.6 -1.1 1.9 2.0 0.0 -0.8 -0.9 -1.5 -1.2 -0.9 -1.8 -1.8 -2.1 -1.4 -1.6 -2.0 -1.8
Maternal smoking around birth 0.1 0.1 0.5 -0.0 0.5 -0.3 -0.4 0.0 -0.0 -0.1 -0.1 0.4 0.0 0.1 0.2 -0.1 0.2 0.7 0.1 0.1
Fed-up feelings 0.9 1.7 5.4 1.0 -1.5 1.7 1.9 0.0 -0.4 -0.1 -2.3 -1.0 -0.3 -1.2 -1.2 -1.2 -0.8 -1.7 -1.6 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 1.9 -1.3 1.0 0.8 1.3 0.0 1.3 1.1 -1.3 0.5 1.3 0.9 1.0 1.4 1.1 0.8 0.7 0.9
Relative age voice broke 0.3 0.5 1.2 -0.5 1.1 0.8 0.8 0.0 0.9 0.6 -0.7 0.6 0.8 0.5 0.6 0.1 0.9 0.9 0.4 0.5
Taking other prescription medications 1.3 2.0 5.3 1.6 -1.6 2.2 2.0 0.0 -0.3 -0.0 -2.3 -0.9 -0.3 -1.3 -1.3 -1.9 -0.6 -1.4 -1.5 -1.3
Age when periods started (menarche) 0.9 2.1 3.9 1.4 -1.7 -0.7 -0.7 0.0 -1.9 -1.9 0.9 -2.0 -1.8 -1.5 -1.5 -1.5 -1.6 -1.4 -1.3 -1.4
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.7 -1.3 0.8 -0.6 -0.4 0.0 0.7 0.9 0.8 1.1 0.9 1.1 1.1 1.2 0.8 0.7 1.0 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.9 1.9 5.6 -1.2 0.9 2.1 2.4 0.0 1.8 2.0 -2.0 1.6 1.7 0.7 0.6 0.1 1.4 0.2 0.7 0.7
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.6 -1.2 1.1 0.3 0.3 0.0 1.1 1.2 -0.2 0.9 1.2 1.1 1.0 0.7 0.9 0.5 0.6 1.1
Qualifications: CSEs or equivalent 0.8 1.1 3.1 -0.4 0.2 1.8 1.5 0.0 1.4 1.6 -1.8 1.0 1.4 0.6 0.6 -0.6 1.1 0.2 0.1 0.7
Serious illness, injury or assault to yourself 2.0 2.4 4.6 -1.2 1.3 1.4 1.2 0.0 2.2 2.0 -1.6 2.0 2.1 1.5 1.5 0.5 2.0 1.4 1.2 1.4
High blood pressure 0.4 1.2 5.1 0.3 -0.8 2.2 2.2 0.0 0.4 0.9 -2.1 0.1 0.5 -0.5 -0.6 -1.2 -0.2 -0.9 -1.0 -0.5
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.8 0.5 -0.4 1.3 1.3 0.0 0.3 0.1 -1.3 -0.2 0.1 -0.5 -0.5 -0.5 0.1 -0.2 -0.3 -0.5
Multivitamins +/- minerals 2.8 3.5 5.7 -2.4 1.2 0.3 0.7 0.0 2.1 2.1 -0.4 2.3 2.2 2.1 2.1 2.4 2.1 2.1 2.4 2.0
Stomach or abdominal pain in last month 0.1 0.1 0.2 -0.5 0.4 -0.4 -0.3 0.0 0.2 0.1 0.4 -0.0 0.2 0.4 0.4 0.3 0.0 0.3 0.2 0.4
Supplements: Glucosamine 0.1 0.1 0.4 -0.4 0.4 -0.4 -0.2 0.0 0.1 0.0 0.7 -0.2 0.1 0.3 0.3 0.6 0.2 0.2 0.3 0.3
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 3.1 1.5 -0.7 -0.5 -0.8 0.0 -1.4 -1.8 0.5 -1.7 -1.6 -1.2 -1.2 -1.1 -1.2 -1.0 -1.2 -1.3
Medication: Atenolol 0.2 0.2 0.5 0.4 -0.4 -0.6 -0.7 0.0 -0.6 -0.6 0.6 -0.2 -0.5 -0.4 -0.4 -0.0 -0.4 -0.4 -0.3 -0.3
Medication: Levothyroxine sodium 0.8 1.3 2.7 1.4 -0.4 -1.3 -1.6 0.0 -1.5 -1.3 1.3 -1.5 -1.5 -0.9 -0.9 -0.8 -1.2 -1.0 -0.9 -1.0
Sitting height 0.1 0.8 4.4 -0.4 -0.2 -1.8 -1.7 0.0 -0.8 -0.6 2.1 -0.1 -0.6 0.2 0.2 1.0 -0.3 0.1 0.6 0.3
Chronic bronchitis/emphysema (father) 0.4 0.5 2.4 0.4 0.6 1.3 1.3 0.0 0.6 0.3 -1.5 -0.2 0.3 -0.3 -0.2 -0.8 0.0 -0.2 -0.7 -0.3
High blood pressure (mother) 0.8 1.1 2.4 1.5 -0.6 1.2 0.9 0.0 -0.4 -0.6 -1.2 -0.9 -0.7 -1.3 -1.2 -1.5 -0.8 -1.1 -1.4 -1.3
Body mass index (BMI) 0.1 0.6 1.7 0.4 -1.3 1.0 1.2 0.0 -0.3 0.2 -1.2 -0.2 -0.1 -0.7 -0.7 -1.0 -0.5 -1.2 -0.9 -0.6
Impedance of leg (left) 0.1 0.7 2.6 -0.4 0.9 -1.6 -1.6 0.0 -0.1 -0.4 1.5 0.2 -0.2 0.6 0.5 1.1 0.3 0.9 0.9 0.5
Leg predicted mass (left) 0.1 0.4 1.2 -0.9 0.1 0.4 0.5 0.0 0.6 1.1 -0.4 0.9 0.9 0.6 0.6 0.4 0.6 0.0 0.4 0.6
Trunk fat mass 0.2 0.9 3.0 0.7 -1.5 0.1 0.3 0.0 -1.1 -0.5 -0.1 -0.8 -0.8 -1.0 -1.1 -0.8 -1.1 -1.7 -1.2 -1.0
Waist circumference 0.1 0.5 1.8 0.0 -1.0 1.2 1.3 0.0 0.1 0.6 -1.3 0.2 0.3 -0.3 -0.3 -0.7 -0.1 -0.9 -0.6 -0.3
Number of incorrect matches in round 1.3 2.2 4.7 1.5 -1.6 -1.3 -1.6 0.0 -2.2 -1.6 1.6 -1.5 -1.7 -1.2 -1.2 -1.2 -1.8 -1.5 -1.4 -1.2
Past tobacco smoking 2.7 5.0 10.3 2.5 -0.9 -1.5 -1.7 0.0 -2.9 -3.2 1.9 -2.6 -3.2 -2.5 -2.4 -1.6 -2.6 -1.7 -1.8 -2.6
Alcohol usually taken with meals 2.0 3.2 5.5 1.9 -1.9 0.6 0.7 0.0 -2.1 -1.8 0.1 -1.8 -1.9 -2.3 -2.3 -1.8 -2.2 -2.1 -1.7 -2.3
Nervous feelings 0.2 0.3 1.8 0.2 -0.0 1.1 0.9 0.0 0.6 0.5 -1.4 -0.3 0.4 -0.1 -0.1 -0.3 0.1 -0.2 -0.6 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.9 -0.3 -0.4 0.8 0.8 0.0 0.5 0.8 -0.9 -0.2 0.6 0.3 0.3 0.5 0.3 -0.2 -0.2 0.3
Hearing difficulty/problems with background noise 0.9 1.4 6.1 1.2 -0.8 2.5 1.9 0.0 0.7 0.6 -2.5 0.1 0.4 -0.7 -0.6 -1.5 0.2 -0.8 -1.0 -0.6
Hair/balding pattern: Pattern 2 0.2 0.2 0.8 0.6 -0.6 -0.2 -0.1 0.0 -0.6 -0.6 0.4 -0.9 -0.6 -0.5 -0.5 -0.0 -0.6 -0.3 -0.4 -0.5
Had menopause 1.3 1.6 3.0 1.3 -1.1 -0.6 -0.6 0.0 -1.7 -1.5 0.7 -1.5 -1.6 -1.4 -1.4 -1.1 -1.7 -1.3 -1.2 -1.3
Had other major operations 0.9 1.1 2.2 0.8 -1.3 1.2 1.3 0.0 -0.6 -0.3 -1.1 -0.7 -0.5 -1.1 -1.2 -1.5 -1.1 -1.2 -1.3 -1.1
Forced vital capacity (FVC) 0.1 0.2 1.2 -0.3 -0.2 -1.0 -1.1 0.0 -0.3 -0.1 0.8 0.0 -0.2 0.3 0.3 0.6 0.0 0.3 0.3 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 6.1 -1.1 1.2 2.2 2.5 0.0 1.8 1.9 -2.1 1.6 1.6 0.6 0.5 -0.2 1.4 0.4 0.6 0.6
Ever unenthusiastic/disinterested for a whole week 3.4 4.2 8.1 -2.1 1.3 1.8 1.9 0.0 2.8 2.8 -2.0 2.0 2.9 2.1 2.0 1.6 2.4 1.8 1.6 2.1
Qualifications: None of the above 0.1 0.1 0.6 -0.5 0.6 0.4 0.8 0.0 0.2 0.1 -0.7 0.1 0.1 -0.2 -0.1 0.3 -0.1 -0.1 0.0 -0.2
Financial difficulties in last 2 years 2.1 2.8 5.5 -1.6 1.0 1.2 1.1 0.0 2.3 2.3 -1.5 1.9 2.3 1.8 1.8 0.9 2.2 1.7 1.2 1.8
Mouth/teeth dental problems 0.2 0.3 1.5 0.6 -0.0 1.2 1.0 0.0 0.3 0.1 -1.1 -0.0 0.2 -0.3 -0.4 -0.6 0.3 -0.2 -0.5 -0.4
Heart attack 0.8 1.0 3.7 -0.7 -0.1 1.7 1.9 0.0 1.2 1.4 -1.7 1.0 1.1 0.4 0.4 0.5 0.8 0.3 0.4 0.4
Allergy 0.5 1.1 4.9 -0.5 0.6 -2.2 -2.1 0.0 -0.6 -0.5 2.2 0.3 -0.4 0.6 0.6 1.1 -0.2 0.6 0.8 0.6
Pain all over the body in last month 0.9 1.0 2.4 -0.7 -0.6 1.1 1.1 0.0 1.1 1.6 -1.2 1.3 1.6 0.9 0.8 0.4 1.2 0.3 0.8 1.0
Diabetes (self-reported) 1.1 1.7 2.8 -1.3 1.2 0.5 0.4 0.0 1.6 1.7 -0.9 1.7 1.6 1.4 1.4 1.4 1.5 1.3 1.4 1.4
Hayfever/allergic rhinitis (self-reported) 1.0 1.4 6.5 0.4 -0.4 2.5 2.1 0.0 1.3 1.0 -2.5 0.5 1.1 0.0 0.1 -0.8 0.9 0.5 -0.2 0.0
Medication: Ramipril 0.6 0.7 2.6 0.5 -1.3 1.4 1.5 0.0 -0.1 0.1 -1.6 0.1 -0.0 -0.7 -0.7 -0.7 -0.3 -0.8 -0.6 -0.7
Medication: Simvastatin 0.4 0.5 1.4 0.8 -0.7 0.7 0.7 0.0 -0.4 -0.1 -0.6 -0.6 -0.3 -0.8 -0.8 -1.1 -0.7 -1.2 -1.0 -0.7
Fluid intelligence score 0.6 1.3 3.2 1.4 -0.3 1.7 1.4 0.0 -0.2 -0.2 -1.8 -0.6 -0.3 -1.2 -1.2 -1.7 -0.6 -1.3 -1.6 -1.2
Illnesses of siblings 1.0 1.5 5.7 0.7 0.2 -2.2 -2.4 0.0 -1.3 -1.6 2.3 -1.1 -1.3 -0.2 -0.2 0.3 -0.6 0.2 -0.0 -0.3
Neuroticism score 0.2 0.5 2.5 -0.3 0.1 1.1 1.2 0.0 0.8 0.8 -1.6 0.0 0.7 0.3 0.3 0.3 0.3 0.1 -0.5 0.2
Weight 0.0 0.2 0.5 -0.4 -0.7 0.4 0.6 0.0 0.1 0.7 -0.4 0.5 0.4 0.1 0.1 -0.1 0.1 -0.6 -0.1 0.1
Impedance of arm (right) 0.2 0.7 1.4 1.1 -0.3 -0.4 -0.5 0.0 -1.0 -1.2 0.4 -1.2 -1.1 -0.9 -1.0 -0.3 -0.9 -0.8 -0.8 -1.0
Arm fat percentage (right) 0.5 1.9 4.6 1.2 -2.1 1.1 1.3 0.0 -1.1 -0.5 -1.3 -1.1 -0.9 -1.5 -1.6 -1.5 -1.4 -2.1 -1.8 -1.5
Trunk fat-free mass 0.2 1.3 3.3 -1.8 0.8 -0.1 0.1 0.0 1.1 1.5 0.3 1.6 1.3 1.3 1.3 1.1 1.3 0.9 1.4 1.4
Hip circumference 0.1 0.4 1.4 0.2 -0.7 1.0 1.2 0.0 -0.1 0.4 -0.9 -0.2 0.1 -0.5 -0.5 -0.7 -0.2 -1.2 -0.6 -0.4
Time employed in main current job 1.2 1.3 2.7 1.2 -1.6 0.2 0.1 0.0 -1.3 -1.0 0.0 -1.4 -1.1 -1.3 -1.3 -1.3 -1.3 -1.6 -1.3 -1.2
Alcohol intake versus 10 years previously 1.1 1.6 3.0 -1.4 1.3 -0.1 -0.3 0.0 1.5 1.7 -0.2 1.4 1.5 1.6 1.6 1.4 1.4 1.0 1.3 1.7
Father’s age at death 1.6 2.2 4.2 1.8 -1.0 -1.2 -1.4 0.0 -2.0 -1.9 1.5 -1.7 -1.9 -1.4 -1.4 -1.0 -1.7 -1.4 -1.3 -1.3
Worrier / anxious feelings 0.1 0.2 0.8 0.2 -0.3 -0.2 -0.0 0.0 -0.4 -0.6 -0.1 -0.9 -0.6 -0.3 -0.3 0.5 -0.6 -0.1 -0.5 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 5.2 -0.1 -0.7 1.9 2.3 0.0 0.5 0.5 -2.1 -0.5 0.4 -0.4 -0.4 -0.3 0.1 -0.6 -0.6 -0.4
Falls in the last year 1.0 1.4 3.3 1.1 -1.8 0.1 0.3 0.0 -1.3 -1.3 -0.3 -1.1 -1.2 -1.3 -1.4 -1.2 -1.5 -1.3 -1.5 -1.4
Hair/balding pattern: Pattern 3 0.1 0.1 0.3 -0.2 0.1 -0.6 -0.3 0.0 -0.5 -0.6 0.6 -0.4 -0.5 -0.2 -0.2 0.5 -0.4 -0.4 -0.0 -0.2
Number of live births 1.6 2.3 4.1 1.9 -0.1 0.3 0.2 0.0 -1.4 -1.9 -0.4 -2.0 -1.8 -1.9 -1.9 -1.7 -1.6 -1.6 -1.8 -2.0
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 1.7 -1.1 0.6 -1.3 -1.2 0.0 0.4 0.4 0.9 0.7 0.4 1.1 1.1 1.3 0.8 1.3 1.1 1.1
Pulse rate 0.9 1.5 2.6 1.2 -0.2 -0.0 0.1 0.0 -1.3 -1.6 0.0 -1.4 -1.4 -1.5 -1.4 -1.6 -1.5 -1.1 -1.5 -1.5
Happiness 7.1 8.6 15.7 3.4 -3.0 1.8 1.7 0.0 -2.4 -2.4 -1.7 -3.4 -2.6 -3.5 -3.5 -3.5 -3.1 -3.6 -4.0 -3.5
Noisy workplace 0.4 0.5 2.1 0.3 -0.9 1.3 1.4 0.0 0.1 0.2 -1.4 0.4 0.1 -0.5 -0.5 -0.3 -0.2 -0.6 -0.5 -0.5
Qualifications: A levels/AS levels or equivalent 1.4 3.1 11.6 -1.2 1.2 -3.1 -3.3 0.0 -0.1 -0.1 3.4 0.7 0.1 1.6 1.5 2.2 0.5 1.4 1.8 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.4 -1.0 0.4 0.3 0.2 0.0 1.0 1.1 -0.4 1.2 1.0 0.9 0.8 0.6 0.6 0.5 0.5 1.0
Mouth/teeth dental problems: Dentures 0.3 0.6 1.1 0.6 -1.1 -0.8 -1.0 0.0 -1.0 -1.0 0.6 -0.7 -0.9 -0.6 -0.6 -0.4 -1.0 -0.8 -0.5 -0.6
Asthma 0.7 1.4 5.8 0.7 -0.9 2.4 2.1 0.0 0.7 0.9 -2.4 -0.4 0.6 -0.5 -0.5 -1.5 0.1 -1.0 -1.2 -0.5
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 5.6 -0.1 0.3 -2.4 -2.4 0.0 -1.0 -0.9 2.3 -0.5 -0.8 0.2 0.2 0.8 -0.5 0.3 0.6 0.3
Medication: Cholesterol lowering 0.4 0.6 2.5 -0.4 0.1 1.4 1.6 0.0 1.0 1.0 -1.4 0.6 0.8 0.2 0.2 0.2 0.5 -0.1 0.1 0.2
Depression (self-reported) 0.5 0.5 2.1 0.0 0.4 1.2 0.9 0.0 1.1 0.9 -1.4 0.6 0.9 0.5 0.5 -0.2 0.7 0.3 -0.2 0.4
Medication: Lansoprazole 1.1 1.3 5.0 0.9 -0.6 2.1 2.2 0.0 0.3 -0.0 -2.0 -0.3 -0.2 -1.1 -1.1 -1.0 -0.1 -1.0 -0.7 -1.2
Prospective memory result 1.1 1.3 3.5 -1.9 0.2 -0.2 0.3 0.0 0.9 1.6 0.4 1.4 1.3 1.4 1.3 1.2 1.3 0.7 1.6 1.5
Lung cancer (father) 0.2 0.2 1.5 -0.5 1.2 0.1 0.3 0.0 0.6 0.1 -0.3 0.1 0.4 0.3 0.4 0.2 0.3 0.6 0.1 0.3
Illnesses of mother 0.6 0.7 1.5 -0.9 0.7 -1.1 -1.1 0.0 0.3 0.3 1.1 0.6 0.5 1.0 1.0 0.6 0.7 1.2 1.1 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.8 -1.0 0.3 -1.3 -1.3 0.0 0.1 0.2 1.1 0.5 0.2 0.9 0.9 1.2 0.5 0.9 0.9 0.9
Pulse wave Arterial Stiffness index 1.3 1.6 3.3 -1.1 1.7 0.3 0.2 0.0 1.6 1.2 -0.5 1.7 1.4 1.4 1.4 0.6 1.7 1.8 1.3 1.3
Impedance of arm (left) 0.2 0.7 1.5 1.2 -0.4 -0.5 -0.8 0.0 -1.1 -1.1 0.6 -1.1 -1.1 -0.8 -0.9 -0.3 -1.0 -0.7 -0.8 -0.9
Arm fat mass (right) 0.1 0.6 1.7 0.3 -1.3 0.8 1.0 0.0 -0.5 0.1 -0.9 -0.2 -0.2 -0.7 -0.7 -0.8 -0.6 -1.3 -0.9 -0.7
Trunk predicted mass 0.3 1.5 3.6 -1.9 0.8 -0.1 0.2 0.0 1.2 1.6 0.2 1.7 1.4 1.4 1.4 1.2 1.4 1.0 1.5 1.5
Standing height 0.2 1.9 3.8 -1.8 1.2 -1.5 -1.3 0.0 0.7 0.8 1.7 1.4 0.9 1.5 1.5 1.9 1.2 1.3 1.8 1.6
Length of working week for main job 0.3 0.3 1.5 -0.6 0.3 -1.2 -1.2 0.0 -0.2 0.1 1.0 0.2 0.0 0.5 0.4 0.6 -0.2 -0.0 0.3 0.6
Exposure to tobacco smoke at home 0.0 0.1 0.3 -0.2 -0.3 -0.0 -0.2 0.0 0.1 0.3 -0.3 0.2 0.3 0.2 0.1 -0.6 0.0 -0.2 -0.2 0.2
Breastfed as a baby 0.4 0.5 1.1 0.6 -0.6 -0.3 -0.0 0.0 -1.0 -0.8 0.6 -0.8 -1.0 -0.9 -0.9 -0.5 -0.9 -1.1 -0.5 -0.8
Tense / ‘highly strung’ 0.3 0.5 2.6 0.1 -0.2 1.5 1.2 0.0 0.8 0.9 -1.6 0.2 0.7 0.1 0.0 -0.5 0.3 0.0 -0.5 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.6 6.6 -1.8 1.7 0.5 0.3 0.0 2.3 2.3 -1.1 2.6 2.4 2.2 2.2 1.6 2.2 2.3 1.8 2.2
Hair/balding pattern: Pattern 4 0.1 0.3 2.0 -0.8 1.4 -0.7 -0.4 0.0 0.2 -0.1 0.5 0.4 -0.0 0.4 0.5 0.7 0.1 0.6 0.3 0.3
Birth weight of first child 0.6 1.1 2.6 1.4 -0.6 1.3 1.1 0.0 -0.5 -0.5 -1.1 -0.7 -0.8 -1.2 -1.2 -1.6 -0.9 -1.1 -1.4 -1.3
Peak expiratory flow (PEF) 1.1 2.6 4.6 -1.8 1.4 -1.7 -1.7 0.0 1.0 1.1 1.2 1.4 1.1 2.0 2.0 2.1 1.4 2.1 1.9 2.0
Pulse wave reflection index 1.6 2.0 3.4 -1.3 1.3 -0.8 -1.0 0.0 1.3 1.2 0.6 1.8 1.4 1.8 1.8 1.4 1.6 1.7 1.8 1.8
Ever highly irritable/argumentative for 2 days 1.7 2.1 5.2 -1.4 0.9 1.6 1.6 0.0 2.1 2.3 -1.7 1.3 2.0 1.3 1.3 0.7 1.6 0.8 0.9 1.3
Loud music exposure frequency 0.2 0.3 0.8 -0.3 0.4 0.6 0.4 0.0 0.9 0.7 -0.6 0.5 0.7 0.5 0.5 0.4 0.5 0.5 0.1 0.4
Qualifications: O levels/GCSEs or equivalent 1.4 2.2 9.9 0.2 0.1 -2.9 -3.0 0.0 -1.4 -1.6 3.1 -1.1 -1.4 -0.0 0.0 0.9 -0.8 0.3 0.3 -0.0
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 1.1 -0.0 -0.2 -1.1 -0.7 0.0 -0.7 -0.6 1.0 -0.7 -0.7 -0.3 -0.3 0.1 -0.8 -0.6 -0.2 -0.3
Blood clot in the leg (DVT) 0.2 0.3 0.5 0.7 -0.7 -0.3 -0.5 0.0 -0.7 -0.6 0.1 -0.5 -0.7 -0.5 -0.5 -0.7 -0.5 -0.3 -0.2 -0.5
Medication: Paracetamol 0.5 0.9 1.9 -0.9 1.3 0.6 0.7 0.0 1.4 1.3 -0.8 1.0 1.2 0.9 0.9 0.5 1.0 0.9 0.7 1.0
Headache pain in last month 0.1 0.1 0.4 -0.4 0.2 -0.6 -0.5 0.0 -0.0 0.3 0.5 0.3 0.1 0.4 0.3 0.6 -0.1 0.2 0.4 0.4
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.0 -0.5 0.5 -1.4 -1.4 0.0 -0.1 -0.4 1.3 0.2 -0.1 0.6 0.6 0.8 0.2 0.8 0.6 0.6
Glaucoma (self-reported) 2.3 2.7 4.2 1.7 -1.8 0.4 0.5 0.0 -1.7 -1.8 -0.6 -1.9 -1.8 -2.0 -2.0 -1.5 -2.0 -1.7 -2.0 -2.0
Gout (self-reported) 0.5 0.7 2.9 0.5 -0.2 -1.5 -1.7 0.0 -1.0 -0.9 1.4 -0.6 -0.9 -0.2 -0.2 -0.1 -0.5 -0.3 -0.1 -0.2
Hypothyroidism/myxoedema (self-reported) 1.1 2.1 3.8 1.7 -0.7 -1.2 -1.5 0.0 -1.9 -1.9 1.3 -1.8 -1.9 -1.4 -1.4 -1.1 -1.6 -1.3 -1.2 -1.5
Medication: Amlodipine 0.1 0.2 0.8 -0.4 0.4 0.7 0.9 0.0 0.5 0.4 -0.6 0.5 0.5 0.2 0.1 -0.1 0.2 0.1 0.1 0.2
Medication: Ventolin 100micrograms inhaler 1.5 2.0 8.9 0.4 0.1 3.0 2.7 0.0 1.4 1.3 -2.9 0.2 1.1 -0.2 -0.2 -1.5 0.7 -0.2 -0.8 -0.2
Birth weight 0.1 0.2 1.3 0.4 -0.3 -0.7 -1.1 0.0 -0.5 -0.3 0.7 -0.1 -0.3 0.0 0.0 -0.1 -0.2 0.0 0.2 -0.0
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.4 0.6 -0.1 0.1 -0.1 0.0 -0.3 -0.6 -0.0 -0.4 -0.4 -0.3 -0.3 -0.3 -0.3 0.2 -0.3 -0.4
High blood pressure (siblings) 1.1 1.6 3.6 -0.9 0.8 1.5 1.4 0.0 1.8 1.9 -1.5 1.6 1.7 1.1 1.1 0.7 1.4 0.9 0.8 1.1
Forced vital capacity (FVC), Best measure 0.1 0.2 0.9 -0.0 -0.7 -0.9 -0.9 0.0 -0.7 -0.4 0.8 -0.3 -0.5 -0.1 -0.1 0.3 -0.3 -0.4 -0.1 -0.1
Body fat percentage 0.4 1.4 4.0 1.1 -1.8 0.7 0.8 0.0 -1.1 -0.5 -0.8 -0.9 -0.8 -1.3 -1.4 -1.3 -1.2 -2.0 -1.5 -1.3
Leg fat percentage (right) 0.1 0.4 1.4 0.2 -1.2 0.7 0.8 0.0 -0.3 0.3 -0.9 0.1 0.0 -0.4 -0.5 -0.9 -0.5 -1.1 -0.7 -0.4
Arm fat-free mass (right) 0.2 0.8 2.3 -1.5 0.6 -0.4 -0.2 0.0 0.7 1.1 0.5 1.3 1.0 1.1 1.1 0.9 0.9 0.7 1.1 1.1
Exposure to tobacco smoke outside home 0.8 1.0 5.1 -0.6 -0.4 1.7 1.9 0.0 1.1 1.2 -2.3 0.5 1.0 0.3 0.3 -0.6 0.4 -0.2 -0.4 0.3
Comparative body size at age 10 0.2 0.5 2.3 -0.5 -0.3 -1.5 -1.1 0.0 -0.8 -0.5 1.3 -0.2 -0.5 0.1 0.1 0.8 -0.6 -0.1 0.2 0.1
Number of full brothers 0.6 0.8 3.1 0.4 -0.6 1.7 1.8 0.0 0.3 0.3 -1.8 -0.1 0.2 -0.6 -0.6 -1.3 -0.2 -0.6 -0.8 -0.5
Worry too long after embarrassment 0.5 0.9 2.7 1.1 -0.2 1.3 1.3 0.0 -0.2 -0.4 -1.7 -0.8 -0.5 -1.0 -1.0 -0.9 -0.7 -0.7 -1.3 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 5.6 7.2 12.0 -2.7 2.3 0.4 0.0 0.0 3.3 3.5 -0.7 3.2 3.4 3.3 3.3 2.4 3.1 3.1 2.7 3.3
Wheeze or whistling in the chest in last year 1.5 2.8 10.0 1.5 -1.2 3.1 2.9 0.0 0.3 0.5 -3.2 -0.5 0.1 -1.4 -1.4 -1.9 -0.5 -1.7 -1.7 -1.3
Number of children fathered 0.6 0.7 1.7 0.6 -0.7 -1.3 -1.3 0.0 -1.2 -1.0 1.2 -0.8 -0.9 -0.4 -0.4 -0.4 -0.9 -0.7 -0.4 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.7 -0.4 0.6 -0.2 -0.2 0.0 0.4 0.2 0.4 0.1 0.2 0.5 0.5 0.8 0.6 0.8 0.6 0.4
Age at first live birth 0.1 0.1 0.4 -0.4 0.2 -0.1 0.0 0.0 0.2 0.4 0.4 0.5 0.2 0.2 0.2 0.6 0.1 -0.1 0.5 0.2
Pulse wave peak to peak time 1.4 1.6 3.3 1.0 -1.6 -0.5 -0.4 0.0 -1.6 -1.2 0.7 -1.6 -1.4 -1.3 -1.4 -0.5 -1.8 -1.8 -1.2 -1.2
Health satisfaction 2.6 3.4 9.7 1.8 -3.1 1.2 1.2 0.0 -1.7 -1.1 -1.0 -1.7 -1.4 -2.1 -2.2 -1.9 -1.9 -2.8 -2.1 -2.0
Shortness of breath walking on level ground 0.7 0.8 2.0 0.9 -1.4 0.6 0.8 0.0 -0.7 -0.6 -0.5 -0.7 -0.8 -1.1 -1.1 -0.9 -1.1 -1.3 -1.1 -1.1
Qualifications: College or University degree 0.9 2.7 4.8 -2.0 1.4 -0.8 -0.7 0.0 1.5 1.6 1.3 1.7 1.5 2.0 1.9 2.0 1.6 2.1 2.2 2.0
Eye problems/disorders: None of the above 2.2 2.6 8.1 -1.2 2.2 -2.8 -2.8 0.0 0.1 -0.2 2.7 0.5 0.0 1.4 1.4 2.0 0.7 1.3 1.6 1.3
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.9 0.0 -1.7 1.0 1.3 0.0 -0.1 0.2 -1.1 -0.1 0.1 -0.5 -0.5 -0.6 -0.3 -0.9 -0.7 -0.4
Emphysema/chronic bronchitis 2.1 2.4 4.4 1.5 -2.1 0.7 0.9 0.0 -1.4 -1.2 -0.6 -1.9 -1.4 -1.8 -1.8 -1.7 -1.6 -2.0 -2.0 -1.7
Medication for pain relief, constipation, heartburn 0.7 1.2 2.9 1.7 -0.9 0.5 0.1 0.0 -1.1 -1.1 -0.2 -1.0 -1.1 -1.3 -1.3 -1.6 -1.0 -1.1 -1.4 -1.3
Neck or shoulder pain in last month 1.9 2.7 4.6 1.7 -1.2 -0.4 -0.1 0.0 -2.0 -2.0 0.5 -2.1 -2.1 -2.0 -2.0 -1.3 -2.0 -2.0 -1.7 -2.0
Medication: Blood pressure 0.2 0.4 1.0 0.6 -0.8 1.0 0.8 0.0 -0.1 0.2 -0.9 -0.3 -0.0 -0.6 -0.6 -1.0 -0.3 -0.7 -0.6 -0.5
Angina (self-reported) 5.7 7.4 12.5 2.9 -3.5 0.1 0.0 0.0 -3.1 -2.8 0.1 -3.3 -3.1 -3.2 -3.3 -2.4 -3.3 -3.3 -2.9 -3.2
Migraine (self-reported) 1.7 2.2 3.7 1.5 -1.5 -0.4 -0.2 0.0 -1.9 -1.9 0.3 -1.9 -1.9 -1.7 -1.7 -1.0 -1.9 -1.4 -1.5 -1.7
Medication: Ibuprofen 0.6 0.7 2.6 0.2 -0.4 -1.6 -1.6 0.0 -1.1 -0.9 1.6 -0.7 -0.9 -0.2 -0.2 0.2 -0.8 -0.3 0.1 -0.1
Medication: Allopurinol 0.6 0.7 3.3 0.0 -0.5 -1.8 -1.8 0.0 -1.1 -0.6 1.7 -0.3 -0.7 0.1 0.0 0.3 -0.6 -0.3 0.2 0.1
Medication: Omeprazole 0.1 0.1 0.4 -0.3 -0.7 -0.6 -0.4 0.0 -0.5 -0.2 0.6 -0.3 -0.2 -0.0 -0.1 0.1 -0.4 -0.2 0.2 0.0
Medication: Seretide 50 evohaler 0.6 0.7 1.9 1.1 -1.4 0.5 0.3 0.0 -0.6 -0.6 -0.3 -1.2 -0.6 -0.8 -0.8 -1.1 -0.7 -0.8 -1.3 -0.8
Mean time to correctly identify matches 0.3 0.6 1.4 0.7 -1.2 1.1 1.1 0.0 -0.3 -0.1 -1.1 -0.5 -0.1 -0.7 -0.7 -1.0 -0.3 -0.7 -0.7 -0.7
Heart disease (mother) 1.2 1.4 2.4 1.4 -0.9 1.3 1.6 0.0 -0.6 -1.0 -1.2 -1.3 -0.9 -1.5 -1.5 -1.1 -1.0 -1.2 -1.3 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 1.0 1.0 -0.3 0.0 -0.0 0.0 -0.7 -1.0 -0.1 -0.8 -0.9 -0.9 -0.9 -0.1 -0.6 -0.4 -0.4 -1.0
Whole body fat mass 0.1 0.5 1.9 0.4 -1.2 0.3 0.4 0.0 -0.7 -0.1 -0.4 -0.4 -0.4 -0.7 -0.7 -0.6 -0.8 -1.4 -0.8 -0.6
Leg fat mass (right) 0.0 0.2 0.8 -0.2 -0.9 0.4 0.6 0.0 -0.1 0.5 -0.6 0.4 0.2 -0.1 -0.1 -0.4 -0.2 -0.8 -0.3 -0.0
Arm predicted mass (right) 0.1 0.6 2.0 -1.4 0.5 -0.5 -0.3 0.0 0.5 0.9 0.7 1.0 0.8 0.9 0.9 0.9 0.7 0.4 1.0 0.9
Pulse rate, automated reading 0.1 0.4 1.0 0.3 -0.1 -0.4 -0.3 0.0 -0.9 -1.0 0.4 -0.9 -0.8 -0.6 -0.6 -0.4 -0.8 -0.6 -0.7 -0.7
Alcohol intake frequency. 3.3 7.6 11.5 -2.9 3.2 0.6 0.4 0.0 3.4 3.2 -0.9 3.2 3.3 3.1 3.1 2.6 3.4 2.9 3.1 3.1
Comparative height size at age 10 0.5 2.8 8.6 -1.7 1.2 -2.7 -2.6 0.0 0.0 0.4 2.9 0.7 0.4 1.6 1.6 2.6 0.6 1.1 1.9 1.6
Number of full sisters 1.3 1.6 2.8 -0.9 1.5 1.2 1.1 0.0 1.7 1.6 -1.5 1.5 1.6 1.1 1.1 0.3 1.5 1.2 0.9 1.1
Suffer from ‘nerves’ 0.4 0.6 2.6 -0.2 0.3 1.5 1.6 0.0 0.7 0.7 -1.6 -0.1 0.5 -0.1 -0.1 -0.4 0.2 -0.5 -0.6 -0.1
Overall health rating 1.1 2.4 5.6 1.4 -2.4 1.9 1.9 0.0 -0.8 -0.2 -1.9 -1.0 -0.7 -1.6 -1.7 -1.4 -1.1 -2.3 -1.8 -1.5
Chest pain or discomfort 0.8 1.2 4.0 0.6 -0.9 1.8 2.0 0.0 0.1 0.2 -1.8 -0.4 -0.0 -0.9 -0.9 -1.3 -0.6 -1.3 -1.3 -0.9
Had major operations 0.1 0.1 0.5 0.1 0.6 0.2 0.1 0.0 0.5 0.1 -0.3 0.3 0.2 0.2 0.3 0.1 0.3 0.7 0.3 0.1
Age at last live birth 0.3 0.4 1.0 -0.4 1.0 0.7 0.7 0.0 1.0 0.8 -0.5 0.7 0.6 0.4 0.5 0.5 0.6 0.3 0.4 0.4
Family relationship satisfaction 0.1 0.1 0.8 -0.2 -0.0 0.7 0.9 0.0 0.4 0.2 -0.6 -0.4 0.2 -0.0 0.0 -0.1 0.1 -0.1 -0.3 -0.0
Leg pain on walking 4.4 5.5 10.2 2.6 -3.0 1.1 1.0 0.0 -2.2 -1.8 -1.0 -2.4 -2.2 -2.8 -2.8 -2.8 -2.5 -3.2 -3.0 -2.7
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 3.2 -1.0 0.7 1.2 1.3 0.0 1.6 1.8 -1.5 1.8 1.8 1.1 1.1 0.3 1.4 0.8 0.8 1.2
Commuting to job workplace: Car/motor vehicle 4.4 5.0 8.3 2.2 -2.5 0.0 0.3 0.0 -2.6 -2.4 0.3 -2.4 -2.7 -2.7 -2.7 -2.0 -2.7 -2.9 -2.6 -2.7
Illness, injury, bereavement, stress in last 2 years 3.7 4.6 8.8 2.0 -1.5 -1.5 -1.2 0.0 -2.9 -2.9 1.8 -2.7 -3.0 -2.3 -2.4 -1.1 -2.6 -2.2 -1.5 -2.3
Medication: Aspirin 1.8 2.4 4.8 -1.7 1.1 1.6 2.0 0.0 2.2 2.1 -1.8 1.6 1.9 1.2 1.2 1.6 1.7 1.0 1.4 1.2
Supplements: Vitamin C 1.0 1.2 2.3 -1.1 0.7 -0.9 -0.9 0.0 1.0 0.8 0.7 0.9 1.0 1.4 1.4 1.4 1.1 1.3 1.5 1.4
Knee pain experienced in last month 0.9 1.4 4.0 1.5 -0.6 1.6 1.4 0.0 -0.3 -0.5 -1.6 -0.7 -0.6 -1.4 -1.3 -2.0 -0.6 -1.1 -1.4 -1.4
Hypertension (Self-reported) 0.3 1.0 4.4 -0.1 -0.6 2.0 2.1 0.0 0.6 1.1 -1.9 0.4 0.8 -0.2 -0.2 -0.8 0.1 -0.6 -0.5 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 2.6 1.4 -1.0 0.9 0.9 0.0 -0.9 -1.2 -0.8 -1.2 -1.2 -1.6 -1.5 -1.6 -1.3 -1.1 -1.3 -1.6
Illnesses of father: Heart disease 0.6 0.8 2.1 -1.4 -0.5 -0.4 -0.2 0.0 0.2 1.2 0.5 0.8 1.0 1.1 1.0 1.4 0.6 -0.1 1.1 1.2
Illnesses of siblings: Diabetes 2.9 3.6 7.6 1.3 -2.2 2.4 2.7 0.0 -0.9 -0.8 -2.4 -1.4 -1.1 -2.2 -2.3 -2.0 -1.6 -2.2 -2.2 -2.2
Smoking status: Previous 1.5 2.2 4.1 -1.7 0.7 0.6 0.5 0.0 1.9 2.0 -0.8 1.7 2.0 1.8 1.8 1.3 1.8 1.4 1.4 1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.3 -0.5 -0.0 -0.0 0.1 0.0 0.2 0.4 -0.0 0.6 0.4 0.4 0.4 0.3 0.5 0.4 0.4 0.4
Whole body fat-free mass 0.2 0.9 2.2 -1.5 0.5 0.1 0.3 0.0 1.0 1.4 0.1 1.3 1.2 1.1 1.1 0.9 1.0 0.6 1.0 1.1
Leg fat-free mass (right) 0.1 0.5 1.4 -0.9 0.1 0.6 0.8 0.0 0.8 1.2 -0.5 1.0 1.0 0.6 0.6 0.5 0.7 0.1 0.5 0.7
Arm fat percentage (left) 0.5 1.8 4.6 1.2 -2.1 1.0 1.1 0.0 -1.1 -0.5 -1.1 -1.1 -0.9 -1.5 -1.5 -1.5 -1.4 -2.1 -1.8 -1.4
Average weekly red wine intake 0.5 0.8 3.2 0.2 0.1 1.8 1.4 0.0 0.9 1.2 -1.4 1.1 1.0 0.2 0.1 -0.8 0.6 0.0 0.1 0.1
Handedness (chirality/laterality): Left-handed 1.0 1.2 3.4 -1.4 1.8 -1.2 -0.8 0.0 0.6 0.2 1.3 0.7 0.3 1.0 1.1 1.6 0.8 1.5 1.4 0.9
Mood swings 0.4 0.7 3.8 -0.4 0.2 1.4 1.4 0.0 1.0 1.2 -1.9 0.6 1.0 0.4 0.4 0.2 0.6 0.0 -0.1 0.4
Loneliness, isolation 0.4 0.6 1.3 -0.4 0.3 0.9 0.8 0.0 1.1 1.0 -1.1 0.4 1.0 0.7 0.8 0.5 0.8 0.7 0.1 0.7
Long-standing illness, disability or infirmity 2.5 3.9 17.3 0.0 -0.2 4.0 3.9 0.0 2.3 2.0 -4.2 1.2 1.9 0.1 0.1 -0.9 1.4 0.0 -0.2 0.1
Ever had bowel cancer screening 0.1 0.1 0.3 0.3 -0.1 0.4 0.4 0.0 -0.3 -0.4 0.0 -0.3 -0.4 -0.6 -0.6 -0.3 -0.2 -0.5 -0.3 -0.5
Diabetes diagnosed by doctor 0.7 1.1 2.0 -1.0 1.0 0.3 0.3 0.0 1.3 1.4 -0.7 1.4 1.2 1.1 1.1 1.4 1.2 1.0 1.3 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.2 0.6 0.0 -0.8 0.6 0.8 0.0 0.3 0.4 -0.6 0.6 0.4 -0.0 0.0 -0.1 0.0 -0.1 -0.1 0.0
Friendships satisfaction 0.2 0.3 1.4 -0.4 0.1 -1.0 -1.0 0.0 -0.3 -0.2 1.2 -0.3 -0.2 0.3 0.2 0.6 -0.3 0.1 0.1 0.3
Qualifications: nursing, teaching 0.1 0.1 0.7 0.1 -0.8 0.1 -0.0 0.0 -0.2 0.2 0.2 -0.5 -0.0 -0.1 -0.2 -0.7 -0.6 -0.4 -0.7 -0.0
Commuting to job workplace: Walk 0.5 0.5 0.9 -0.7 0.9 -0.2 -0.4 0.0 0.7 0.8 0.2 0.4 0.9 0.9 0.9 0.9 0.7 1.0 0.7 1.0
Eye problems/disorders: Cataract 1.7 1.9 5.1 1.3 -2.0 2.3 2.1 0.0 -0.4 -0.2 -2.1 -0.0 -0.4 -1.4 -1.4 -2.0 -0.6 -0.9 -1.2 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.2 -0.1 1.0 -0.8 -1.1 0.0 0.1 0.1 1.1 0.2 0.1 0.5 0.5 0.5 0.3 0.7 0.8 0.5
Medication for cholesterol 1.3 2.0 3.2 -1.7 1.5 -0.3 -0.3 0.0 1.5 1.3 0.1 1.5 1.5 1.7 1.7 1.5 1.8 1.8 1.6 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 2.8 -1.3 0.6 0.4 0.2 0.0 1.6 1.7 -0.5 1.3 1.7 1.5 1.5 0.6 1.6 1.3 1.2 1.5
Back pain experienced in last month 0.1 0.1 0.4 -0.4 -0.4 0.4 0.6 0.0 0.1 0.3 -0.1 0.4 0.1 -0.1 -0.1 -0.4 -0.1 -0.4 -0.2 -0.1
Mineral and other dietary supplements 1.9 2.6 4.7 2.2 -1.3 0.6 0.2 0.0 -1.5 -1.8 -0.6 -1.7 -1.7 -2.0 -1.9 -2.2 -1.6 -1.4 -2.1 -2.0
Breast cancer (self-reported) 0.1 0.2 0.7 0.1 -0.1 -0.5 -0.1 0.0 -0.6 -0.8 0.5 -0.4 -0.6 -0.4 -0.3 0.2 -0.3 0.1 -0.0 -0.4
Asthma (self-reported) 0.8 1.7 7.0 0.8 -0.9 2.6 2.3 0.0 0.8 0.9 -2.6 -0.3 0.7 -0.5 -0.5 -1.7 0.2 -0.9 -1.3 -0.5
Osteoporosis (self-reported) 1.0 1.2 2.8 1.1 -0.9 1.6 1.5 0.0 -0.2 -0.2 -1.7 -0.6 -0.3 -1.1 -1.2 -1.6 -0.8 -1.3 -1.5 -1.1
Osteoarthritis (self-reported) 0.2 0.2 0.5 0.5 -0.2 0.3 0.4 0.0 -0.4 -0.7 -0.3 -0.3 -0.6 -0.7 -0.6 -0.4 -0.3 0.1 -0.1 -0.7
Medication: Aspirin 1.6 2.1 4.5 -1.6 0.6 1.5 1.8 0.0 2.0 2.1 -1.7 1.6 1.9 1.1 1.1 1.3 1.5 0.8 1.3 1.2
Medication: Gliclazide 0.7 0.8 3.2 0.7 -0.4 1.7 1.5 0.0 0.3 0.6 -1.8 0.1 0.2 -0.6 -0.7 -1.0 -0.0 -1.0 -0.6 -0.6
Illnesses of father: None of the above (group 1) 0.2 0.3 1.2 -0.2 0.6 -0.3 -0.4 0.0 0.6 -0.0 0.3 0.5 0.3 0.5 0.5 0.4 0.6 1.1 0.6 0.4
Smoking status: Current 2.8 4.5 8.6 -2.5 1.3 1.0 1.3 0.0 2.7 2.9 -1.5 2.8 2.9 2.3 2.2 1.5 2.3 1.7 2.1 2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.1 0.8 -1.0 -0.5 -0.6 0.0 -1.0 -1.0 0.6 -0.9 -1.0 -0.8 -0.7 -0.7 -0.8 -0.7 -0.7 -0.7
Whole body water mass 0.1 0.8 2.1 -1.4 0.4 0.1 0.3 0.0 0.9 1.3 0.0 1.3 1.1 1.0 1.0 0.8 1.0 0.4 1.0 1.1
Leg predicted mass (right) 0.1 0.5 1.4 -0.9 0.0 0.6 0.7 0.0 0.8 1.2 -0.5 1.0 1.0 0.6 0.7 0.5 0.7 0.1 0.5 0.7
Arm fat mass (left) 0.2 0.6 2.6 0.4 -1.6 0.4 0.6 0.0 -0.8 -0.1 -0.5 -0.4 -0.4 -0.8 -0.8 -0.8 -0.8 -1.5 -0.9 -0.7
Number of self-reported non-cancer illnesses 1.2 2.0 6.6 1.3 -1.0 2.6 2.6 0.0 0.0 -0.0 -2.5 -0.8 -0.1 -1.2 -1.2 -1.8 -0.6 -1.1 -1.6 -1.3
Average weekly champagne plus white wine intake 1.8 2.5 5.1 -2.1 1.2 -0.6 -0.3 0.0 1.4 1.4 0.7 1.6 1.5 1.8 1.9 2.2 1.7 2.0 2.2 1.8
Miserableness 1.3 2.3 5.3 -1.2 0.5 1.5 1.3 0.0 2.1 2.3 -2.0 1.4 2.1 1.5 1.4 0.9 1.7 1.2 0.9 1.5
Guilty feelings 0.4 0.6 2.9 0.7 -0.8 1.4 1.1 0.0 0.2 0.1 -1.7 -0.7 0.1 -0.5 -0.5 -0.5 -0.0 -0.5 -0.9 -0.5
Wears glasses or contact lenses 1.7 2.0 4.1 2.0 -1.6 1.0 0.8 0.0 -1.2 -1.2 -0.7 -1.7 -1.3 -1.8 -1.8 -1.6 -1.3 -1.5 -1.5 -1.7
Ever taken oral contraceptive pill 0.1 0.2 0.4 0.1 0.6 0.3 0.1 0.0 0.5 0.7 -0.1 0.6 0.6 0.5 0.4 -0.2 0.5 0.2 0.2 0.5
Hearing aid user 0.8 0.9 2.0 0.9 -1.2 1.4 1.4 0.0 -0.3 -0.0 -1.1 -0.4 -0.4 -1.0 -1.0 -1.2 -0.6 -1.1 -1.0 -1.0
Mother’s age at death 1.7 2.1 3.3 -1.7 1.4 -0.5 -0.6 0.0 1.3 1.3 0.6 1.7 1.6 1.8 1.7 1.7 1.4 1.7 1.8 1.8
Financial situation satisfaction 0.2 0.2 0.5 -0.0 0.3 -0.4 -0.6 0.0 0.4 0.1 0.2 0.0 0.3 0.6 0.7 0.5 0.7 0.7 0.5 0.6
Tinnitus: Yes, now most or all of the time 0.5 0.5 1.4 -0.4 0.1 0.3 -0.1 0.0 0.9 0.9 -0.2 0.7 0.9 0.9 0.9 0.8 1.2 0.9 0.9 0.8
Commuting to job workplace: Public transport 6.2 7.4 14.7 -2.4 2.4 2.5 2.5 0.0 3.8 3.4 -2.7 2.9 3.6 2.6 2.6 1.4 3.5 2.9 2.3 2.5
Eye problems/disorders: Glaucoma 1.7 2.0 3.7 1.2 -1.7 1.1 1.3 0.0 -1.1 -1.0 -1.2 -1.4 -1.1 -1.6 -1.7 -1.4 -1.6 -1.7 -1.9 -1.6
Medication: Blood pressure 0.6 1.1 2.0 1.1 -1.4 0.6 0.7 0.0 -1.1 -0.8 -0.5 -0.9 -0.9 -1.3 -1.3 -1.2 -1.3 -1.4 -1.3 -1.2
Pain type(s) experienced in last month: Hip pain 1.9 2.3 7.2 -0.8 0.1 2.5 2.6 0.0 2.0 2.1 -2.7 1.7 1.8 0.7 0.7 -0.3 1.5 0.4 0.6 0.7
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.9 -1.6 0.6 -0.8 -0.3 0.0 0.5 0.8 0.7 0.9 0.8 1.1 1.0 1.7 0.6 0.7 1.4 1.2
High cholesterol (Self-reported) 1.3 2.2 3.8 1.5 -1.8 -0.9 -0.9 0.0 -1.9 -1.8 1.1 -1.8 -1.8 -1.5 -1.5 -0.9 -1.8 -1.8 -1.4 -1.4
Medication: Bendroflumethiazide 1.7 2.6 4.6 1.9 -1.4 -0.5 -0.7 0.0 -2.0 -1.6 0.7 -2.0 -1.8 -1.7 -1.7 -1.5 -2.0 -2.1 -1.9 -1.6
Medication: Paracetamol 0.4 0.6 1.8 -0.5 0.5 1.2 1.3 0.0 1.0 1.2 -1.3 0.5 0.9 0.3 0.3 -0.0 0.4 -0.0 -0.0 0.4
Medication: Lisinopril 1.4 1.8 3.6 1.4 -1.4 -0.2 -0.4 0.0 -1.6 -1.2 0.1 -1.4 -1.4 -1.5 -1.6 -1.6 -1.8 -1.9 -1.7 -1.4
Medication: Atorvastatin 0.1 0.2 0.7 0.3 -0.8 0.1 0.4 0.0 -0.5 -0.5 -0.1 -0.1 -0.5 -0.6 -0.5 0.3 -0.4 -0.2 -0.1 -0.5
Illnesses of father: High blood pressure 0.9 1.2 2.0 1.2 -0.9 -0.0 0.1 0.0 -1.3 -1.2 0.1 -1.2 -1.4 -1.4 -1.3 -0.7 -1.4 -1.3 -1.3 -1.3
Alcohol drinker status: Never 1.6 2.0 6.2 -1.0 1.3 -2.4 -2.4 0.0 -0.1 -0.3 2.5 0.4 -0.1 1.1 1.1 1.8 0.8 1.5 1.8 1.1
Ever smoked 3.9 6.8 13.8 -2.8 0.9 2.0 2.3 0.0 3.4 3.7 -2.7 3.1 3.6 2.7 2.6 1.7 3.0 2.0 2.0 2.8
Basal metabolic rate 0.1 0.5 1.4 -1.2 0.1 0.2 0.4 0.0 0.7 1.1 -0.1 1.1 0.9 0.8 0.7 0.6 0.7 0.2 0.7 0.8
Leg fat percentage (left) 0.2 0.7 1.9 0.4 -1.4 1.1 1.3 0.0 -0.3 0.3 -1.3 -0.0 -0.0 -0.7 -0.7 -1.1 -0.5 -1.4 -0.9 -0.6
Arm fat-free mass (left) 0.2 0.8 2.3 -1.5 0.3 0.1 0.4 0.0 0.8 1.2 0.0 1.3 1.1 1.0 1.0 0.8 0.9 0.5 1.0 1.0
Number of operations (self-reported) 0.1 0.2 0.5 0.2 -0.4 0.3 0.5 0.0 -0.2 -0.2 -0.2 -0.1 -0.3 -0.5 -0.5 -0.7 -0.6 -0.5 -0.5 -0.4
Average weekly beer plus cider intake 3.0 4.4 7.9 2.1 -2.4 0.0 0.2 0.0 -2.3 -2.1 -0.3 -2.2 -2.3 -2.4 -2.4 -2.1 -2.7 -2.8 -2.7 -2.4
Irritability 0.9 1.4 7.0 0.4 -0.3 2.5 2.3 0.0 1.0 0.9 -2.6 0.4 0.9 -0.3 -0.3 -1.1 0.4 -0.5 -0.9 -0.3
Risk taking 6.2 9.1 15.4 -3.5 2.8 0.6 0.7 0.0 3.7 3.7 -0.7 3.9 3.7 3.5 3.5 2.6 3.6 3.2 3.4 3.5
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.3 0.0 0.6 0.2 0.3 0.0 0.1 -0.1 0.1 0.1 -0.0 -0.0 0.0 0.2 0.2 0.4 0.3 -0.1
Fractured/broken bones in last 5 years 0.6 0.8 2.4 -0.7 1.6 0.7 0.8 0.0 1.4 0.9 -1.1 0.9 1.1 0.8 0.9 0.2 0.9 0.7 0.3 0.8
Age started oral contraceptive pill 0.4 0.5 2.3 0.1 0.2 -1.3 -1.4 0.0 -0.6 -0.7 1.5 -0.2 -0.6 0.0 0.0 0.6 -0.2 0.1 0.4 -0.0
Diastolic blood pressure, automated reading 0.2 0.7 1.4 1.0 -1.2 0.2 0.3 0.0 -0.8 -0.7 -0.2 -1.0 -0.9 -1.0 -1.0 -0.6 -1.0 -1.2 -1.2 -0.9
Ever depressed for a whole week 2.3 2.8 5.3 -1.6 1.4 1.2 1.2 0.0 2.2 2.3 -1.3 1.8 2.3 1.8 1.8 1.3 1.9 1.5 1.4 1.8
Unable to work because of sickness or disability 0.5 0.6 1.5 0.7 -1.0 0.5 0.6 0.0 -0.5 -0.5 -0.7 -0.8 -0.5 -0.8 -0.9 -0.9 -0.8 -1.2 -1.2 -0.8
Commuting to job workplace: Cycle 0.3 0.3 0.8 -0.6 -0.1 0.5 0.6 0.0 0.6 0.7 -0.3 0.4 0.8 0.5 0.5 0.6 0.9 0.6 0.7 0.5
Myopia 1.2 1.7 3.1 -1.6 0.9 -0.1 -0.1 0.0 1.4 1.8 0.1 1.6 1.6 1.7 1.6 1.2 1.5 1.1 1.6 1.7
Vascular/heart problems diagnosed by doctor 0.5 1.4 5.2 -0.5 1.4 -2.2 -2.3 0.0 -0.1 -0.7 2.1 0.1 -0.3 0.8 0.8 1.3 0.5 1.0 1.1 0.7
Cholesterol lowering medication 0.8 1.1 2.3 0.9 -1.2 -0.7 -0.5 0.0 -1.5 -1.2 0.9 -1.1 -1.3 -1.1 -1.1 -0.7 -1.5 -1.4 -1.0 -1.0
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.8 -0.2 -0.9 -0.7 -0.5 0.0 -0.7 -0.2 0.7 -0.3 -0.4 -0.2 -0.3 0.1 -0.5 -0.6 0.1 -0.1
Pain experienced in last month 0.6 1.0 1.7 -1.0 1.3 -0.1 -0.2 0.0 1.1 0.9 0.3 1.0 1.2 1.2 1.2 1.2 1.0 1.2 0.9 1.2
Supplements: Calcium 0.2 0.2 1.1 -0.6 1.0 0.0 0.1 0.0 0.6 0.3 -0.1 0.4 0.4 0.5 0.5 0.0 0.6 0.8 0.5 0.4
Basal cell carcinoma (self-reported) 1.2 1.4 3.0 1.1 -1.7 0.1 0.3 0.0 -1.4 -1.0 0.1 -1.2 -1.2 -1.4 -1.4 -1.3 -1.5 -1.4 -1.3 -1.3
Heart attack/myocardial infarction (self-reported) 1.3 1.7 6.0 -0.9 0.2 2.2 2.4 0.0 1.6 1.8 -2.2 1.3 1.5 0.5 0.5 0.5 1.1 0.4 0.4 0.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.7 0.8 -0.6 -0.4 -0.6 0.0 -0.7 -0.7 0.2 -0.4 -0.7 -0.5 -0.5 -0.8 -0.4 -0.2 -0.2 -0.5
Heart disease (siblings) 0.2 0.2 1.0 0.2 -1.0 -0.0 -0.0 0.0 -0.6 -0.2 -0.0 -0.3 -0.4 -0.5 -0.5 -0.2 -0.6 -0.9 -0.4 -0.4
Alcohol drinker status: Previous 2.3 2.6 4.7 -1.5 1.5 1.5 1.4 0.0 2.2 1.9 -1.8 2.0 2.1 1.4 1.5 0.9 2.0 1.6 1.2 1.4
Pack years of smoking 0.1 0.1 0.7 0.1 -0.2 0.5 0.6 0.0 0.2 0.0 -0.8 0.2 0.0 -0.2 -0.3 -0.4 -0.3 -0.0 -0.2 -0.2
Impedance of whole body 0.1 0.7 1.8 0.9 0.2 -1.2 -1.3 0.0 -1.1 -1.3 1.1 -0.9 -1.2 -0.6 -0.6 0.1 -0.8 -0.3 -0.4 -0.7
Leg fat mass (left) 0.1 0.2 1.0 -0.0 -1.0 0.5 0.7 0.0 -0.2 0.5 -0.7 0.3 0.2 -0.2 -0.2 -0.5 -0.2 -0.8 -0.4 -0.2
Arm predicted mass (left) 0.2 0.8 2.2 -1.5 0.4 0.3 0.6 0.0 1.0 1.3 -0.2 1.4 1.1 0.9 0.9 0.7 1.0 0.5 1.0 1.0