TWAS hub - CLU

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.3070	0.0650	3.8e-10	0.204	NA	0.195	NA	0.159	1.8e-11	NA	5.7e-11	NA	4.2e-09
2	GTEx	Artery Coronary	0.4790	0.0980	5.7e-05	-0.009	NA	0.006	NA	0.009	9.6e-01	NA	2.0e-01	NA	1.5e-01
3	GTEx	Small Intestine Terminal Ileum	0.4690	0.1210	1.7e-03	-0.010	NA	-0.012	NA	-0.012	6.0e-01	NA	7.2e-01	NA	7.7e-01
4	TCGA	Brain Lower Grade Glioma	0.0374	0.0189	5.8e-03	-0.002	0.013	0.000	NA	0.000	6.1e-01	0.011	2.8e-01	NA	3.3e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Smoking Status	8.8	21.1	83.6	-0.5	-0.7	0.1	9.1
Smoking status: Current	6.1	9.7	37.3	0.9	0.7	-0.5	6.1
Alcohol intake versus 10 years previously	6.0	9.0	32.7	-0.4	-1.3	1.2	5.7
Current tobacco smoking	5.7	9.2	34.7	1.0	0.9	-0.7	5.9
Schizophrenia (2014)	4.4	9.6	16.2	-3.6	-3.0	-0.7	4.0
Alzheimer’s Disease (including proxy)	4.3	6.2	17.4	-1.3	-1.7	1.7	-4.2
Alzheimer’s Disease (in mother)	3.8	4.5	10.8	-1.4	-1.4	1.8	-3.3
Alcohol intake frequency.	3.7	8.6	13.0	3.6	2.4	-2.5	3.1
Schizophrenia (2018)	3.5	7.2	11.1	-3.2	-2.7	-0.6	3.3
Past tobacco smoking	3.4	6.2	19.6	0.9	2.0	-0.6	-4.4
Eye problems/disorders: Cataract	3.4	3.9	6.1	2.3	2.0	-2.5	-0.1
Bipolar Disorder or Schizophrenia	3.2	7.9	12.7	-3.6	-3.5	-1.1	2.3
Alcohol usually taken with meals	3.1	5.1	18.8	-1.0	0.7	-0.3	-4.3
Diabetes (father)	3.0	3.7	7.1	-1.6	0.1	2.3	-2.7
Father’s age at death	3.0	4.1	12.9	-0.3	0.8	1.6	-3.6
Heart disease (siblings)	3.0	3.6	6.8	1.7	2.1	0.7	2.6
Schizophrenia vs Biploar Disorder	2.9	3.8	13.0	0.0	1.0	-1.1	3.6
Severe depression (siblings)	2.8	3.2	9.3	-1.6	-0.5	3.0	0.8
Happiness	2.8	3.4	9.0	1.2	1.8	-0.0	3.0
Lung cancer (father)	2.7	3.2	12.3	0.2	-0.6	-0.3	3.5
Smoking status: Previous	2.7	4.0	10.3	-1.2	-1.7	1.1	3.2
Long-standing illness, disability or infirmity	2.7	4.1	11.8	-1.3	-1.6	-0.3	3.4
Chronic bronchitis/emphysema (father)	2.6	3.1	7.4	2.0	0.5	-0.8	2.7
Other serious medical condition/disability diagnosed by doctor	2.3	2.9	9.3	0.5	0.7	-1.3	3.0
Mouth/teeth dental problems: Dentures	2.2	3.7	14.5	0.0	-0.2	0.6	3.8
Commuting to job workplace: Public transport	2.2	2.6	4.1	-1.7	-2.0	1.1	-1.5
Frequency of depressed mood in last 2 weeks	2.1	2.9	6.1	2.5	2.1	-1.1	0.5
Shortness of breath walking on level ground	2.1	2.5	3.4	1.8	1.5	1.5	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	8.7	0.9	0.6	0.4	3.0
Heart attack	2.0	2.6	10.0	0.1	0.5	0.2	3.2
Noisy workplace	2.0	2.4	8.2	-0.7	-0.9	0.2	2.9
Health satisfaction	2.0	2.6	4.1	1.5	1.8	0.7	2.0
Emphysema/chronic bronchitis	2.0	2.3	5.6	-0.2	0.8	-1.7	2.4
Depression (Nagel 2018)	1.9	2.8	6.9	2.6	1.8	-0.8	0.7
Townsend deprivation index at recruitment	1.9	2.6	4.0	-1.0	-1.7	1.6	2.0
High blood pressure (mother)	1.9	2.7	5.0	-2.2	-1.9	1.4	-0.5
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	9.0	0.9	1.2	-3.0	-1.2
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	9.6	0.5	1.4	-3.1	-0.3
Breast Cancer	1.8	4.4	15.2	0.4	1.4	-0.6	-3.9
Medication: Co-codamol	1.8	2.1	6.5	0.4	0.9	1.0	2.6
Qualifications: CSEs or equivalent	1.8	2.3	4.5	0.6	2.1	1.2	-1.7
Heart attack/myocardial infarction (self-reported)	1.8	2.3	8.7	0.3	0.7	0.3	3.0
Sensitivity / hurt feelings	1.7	2.9	9.7	0.6	0.7	-0.9	3.1
Had other major operations	1.7	2.1	3.6	-1.5	-1.6	1.9	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.6	-1.9	-1.9	0.5	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	6.6	-0.3	0.4	2.6	-1.0
Average weekly champagne plus white wine intake	1.7	2.4	4.4	-1.7	-1.5	-0.3	-2.1
Guilty feelings	1.7	2.6	5.5	1.4	2.4	-1.2	1.2
Ever taken oral contraceptive pill	1.7	1.9	2.7	-1.6	-0.7	-1.4	-1.6
Financial situation satisfaction	1.7	2.1	4.7	2.2	1.5	0.4	1.0
High cholesterol (Self-reported)	1.7	2.9	6.6	-2.6	-1.6	1.1	1.1
Age started oral contraceptive pill	1.7	2.1	7.7	0.3	-0.7	-2.8	0.2
Bipolar Disorder (2018)	1.6	2.5	5.0	-1.9	-2.2	-1.0	-0.5
Major Depression (MDD)	1.6	1.9	2.4	-1.0	-1.5	1.5	1.4
Lupus	1.6	2.4	4.3	-1.5	-1.2	1.3	-2.1
Neuroticism (2016)	1.6	2.2	4.2	1.1	1.3	2.0	1.4
Type 2 Diabetes (T2D) (2012)	1.6	1.9	5.2	0.8	1.3	-0.2	-2.3
Maternal smoking around birth	1.6	2.4	8.0	-0.8	-0.9	-0.1	2.8
Mouth/teeth dental problems	1.6	2.5	8.4	0.5	0.3	-1.2	-2.9
Medication: Amlodipine	1.6	2.2	5.0	-1.6	-2.2	1.2	0.1
Mother’s age at death	1.6	2.0	5.4	0.7	0.9	1.2	-2.3
Body Mass Index (BMI) (2010)	1.5	2.0	4.8	0.5	2.2	1.3	-1.1
Number of treatments/medications taken	1.5	2.7	4.4	-2.0	-1.1	2.1	1.2
Supplements: Glucosamine	1.5	2.0	5.8	-1.3	-0.1	0.7	-2.4
Overall health rating	1.5	3.2	7.3	1.4	1.0	1.6	2.7
Medication: Aspirin	1.5	1.9	4.5	-1.4	-0.3	2.1	1.1
Supplements: Calcium	1.5	1.6	4.3	-2.1	-1.4	-0.3	-0.5
Cardiovascular Disease	1.4	4.8	9.5	-2.3	-2.0	3.1	0.7
Vitamin and mineral supplements	1.4	1.8	2.9	1.1	1.0	1.5	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	6.0	-2.3	0.1	2.4	-1.2
Medication: Cholesterol lowering	1.4	2.2	6.4	-0.9	-0.6	2.5	1.1
Breastfed as a baby	1.4	1.7	3.2	1.4	1.8	0.5	-1.2
Angina (self-reported)	1.4	1.9	7.2	0.5	0.3	-0.3	2.7
Mood swings	1.4	2.5	4.6	0.7	2.0	2.1	1.1
Commuting to job workplace: Walk	1.4	1.5	3.6	1.1	-1.1	-0.3	-1.9
Medication: Aspirin	1.4	1.8	4.3	-1.4	-0.5	2.1	0.7
Wears glasses or contact lenses	1.4	1.6	3.6	0.8	1.4	1.9	-0.5
Pulse wave reflection index	1.3	1.6	5.4	-2.3	-0.7	0.6	0.2
Eye problems/disorders: None of the above	1.3	1.6	5.3	0.1	0.9	2.3	0.4
Medication: Blood pressure	1.3	2.2	8.5	-0.3	-0.2	2.9	0.5
Diabetes diagnosed by doctor	1.3	2.1	2.5	1.6	1.6	1.3	-1.3
Ever had prostate specific antigen (PSA) test	1.3	1.4	2.7	0.1	-1.3	-1.6	-1.2
Myopia	1.3	1.9	5.0	0.4	2.2	0.6	-1.5
Alcohol drinker status: Previous	1.3	1.5	4.8	0.2	0.8	-0.8	2.2
Mean Putamen Volume	1.2	1.4	2.5	-0.1	1.6	-1.1	1.3
HbA1C	1.2	1.3	3.1	0.5	1.8	0.1	1.4
Primary Biliary Cirrhosis	1.2	1.7	2.9	-1.1	-1.0	1.7	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.2	2.0	1.5	-0.3	-0.1
Medication: Atenolol	1.2	1.5	3.7	0.5	1.0	1.1	1.9
Loud music exposure frequency	1.2	1.4	2.6	0.3	0.8	-1.6	-1.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	5.7	-0.3	-0.7	2.4	-0.1
Chronic bronchitis/emphysema (mother)	1.2	1.3	4.5	-0.0	0.7	-2.1	0.6
Wheeze or whistling in the chest in last year	1.2	2.1	7.4	0.8	0.5	-0.4	2.7
Migraine (self-reported)	1.2	1.5	2.5	-1.6	-1.6	-0.3	1.1
Ever had bowel cancer screening	1.2	1.5	3.6	-0.9	-1.9	0.7	-0.9
Number of self-reported non-cancer illnesses	1.2	2.0	3.6	-1.9	-1.1	0.7	1.6
Medication: Atorvastatin	1.2	1.5	5.7	-0.4	-0.1	2.4	0.2
Ever smoked	1.2	2.0	6.2	-0.6	-1.1	0.7	2.5
Average weekly beer plus cider intake	1.2	1.7	2.3	-1.5	-0.7	1.4	1.5
Depressed Affect (Nagel 2018)	1.1	2.3	4.5	1.3	1.6	2.1	0.7
Prostate Cancer	1.1	1.6	4.2	-1.2	-0.5	-2.1	0.5
Systolic blood pressure, automated reading	1.1	3.1	4.8	-2.0	-1.4	2.2	-1.2
Angina	1.1	1.5	5.3	0.6	0.6	-0.0	2.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.5	1.5	1.6	-0.1	0.7
Diabetes (self-reported)	1.1	1.8	2.9	1.3	1.4	1.7	-0.7
Medication: Seretide 50 evohaler	1.1	1.3	3.6	-0.5	0.1	-1.1	1.9
Heart disease (mother)	1.1	1.3	1.6	1.2	1.2	-0.9	1.2
Hypertension (Self-reported)	1.1	3.0	10.7	-1.0	-0.5	3.3	-0.5
Medication for cholesterol	1.1	1.7	5.4	0.2	-1.0	-0.6	-2.3
Mineral and other dietary supplements	1.1	1.4	4.8	0.3	-0.0	2.2	0.9
Medication: Gliclazide	1.1	1.2	3.0	0.7	0.7	1.7	-0.9
Miserableness	1.1	1.9	5.3	0.6	0.7	2.3	-1.2
Vascular/heart problems diagnosed by doctor	1.1	3.0	10.3	1.0	0.1	-3.2	-0.8
Pain experienced in last month	1.1	1.9	6.5	-0.9	-0.4	2.5	0.3
Fasting Glucose	1.0	1.1	2.7	-0.9	-0.5	1.6	-0.9
Rheumatoid Arthritis	1.0	1.3	4.6	0.1	-0.0	2.1	0.9
High blood pressure	1.0	2.7	9.1	-1.2	-0.3	3.0	-0.4
Qualifications: None of the above	1.0	2.1	6.7	1.0	0.3	0.8	2.6
Blood clot in the leg (DVT)	1.0	1.3	2.7	-0.4	-1.0	1.6	1.2
Exposure to tobacco smoke outside home	1.0	1.4	2.3	-0.9	-1.5	0.4	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.5	0.3	-1.6	0.7	-1.0
Diastolic blood pressure, automated reading	1.0	3.1	6.4	-1.1	0.2	2.2	-2.5
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.1	-0.6	-0.9	1.8	1.1
Type 2 Diabetes (T2D) (2018)	0.9	1.6	3.6	1.9	0.4	1.6	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	4.3	-1.9	-0.0	2.1	-0.5
Had menopause	0.9	1.1	2.6	1.6	1.1	-0.1	-0.7
Financial difficulties in last 2 years	0.9	1.2	2.8	0.8	0.7	-0.8	1.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	4.5	-0.1	-2.1	0.1	0.1
Worrier / anxious feelings	0.9	1.7	5.8	0.7	0.2	-0.7	2.4
Comparative body size at age 10	0.9	2.4	3.2	1.6	1.8	1.2	-1.6
Medication: Omeprazole	0.9	1.0	2.3	1.0	0.7	-0.6	1.5
Knee pain experienced in last month	0.9	1.4	3.2	1.5	0.4	-1.8	0.1
Average weekly red wine intake	0.9	1.3	4.9	-0.3	0.2	0.2	-2.2
Supplements: Fish oil (including cod liver oil)	0.9	1.2	4.2	0.5	0.0	-2.1	-0.4
Ulcerative Colitis (UC)	0.8	1.5	2.8	-1.6	0.7	-0.5	-1.7
Blood Red Count	0.8	7.5	18.1	4.3	3.4	0.3	-0.4
Average weekly spirits intake	0.8	1.0	3.6	-0.2	0.3	0.7	-1.9
Ever had hysterectomy (womb removed)	0.8	0.8	2.3	0.1	-0.3	-1.0	-1.5
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.1	-0.7	-0.8	-0.6	-1.4
Medication for hormone replacement therapy	0.8	0.9	1.8	0.2	1.0	0.9	1.4
Fed-up feelings	0.8	1.5	4.6	0.9	2.1	0.7	-0.3
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.8	0.9	0.7	1.3	-0.7
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	4.6	-0.5	-0.0	-0.1	-2.1
Glaucoma (self-reported)	0.8	0.9	1.8	0.3	-1.3	-1.3	-0.0
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.7	-1.3	-0.6	-0.5	1.3
Leg fat mass (right)	0.8	3.2	6.6	2.3	1.0	2.6	-0.2
Chest pain or discomfort	0.8	1.2	2.0	0.7	1.4	-0.7	1.4
Leg pain on walking	0.8	0.9	3.0	0.8	0.1	0.2	1.7
Loneliness, isolation	0.8	1.1	3.4	1.9	0.8	-0.4	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.9	-0.4	0.4	-0.6	-1.7
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.1	1.4	-0.3	-0.4	1.3
Risk taking	0.8	1.1	4.4	-0.2	-0.3	-0.1	-2.1
Commuting to job workplace: Cycle	0.8	1.0	1.8	-1.4	-1.1	0.7	-0.7
Worry (Nagel 2018)	0.7	1.5	4.4	-0.8	-1.0	-0.0	2.1
Alzheimer’s Disease (in father)	0.7	0.8	1.9	-0.3	-1.1	-0.2	-1.4
Reaction Time	0.7	1.4	2.3	-1.5	-0.7	-1.2	1.2
Bipolar Disorder (2011)	0.7	0.6	1.1	-0.8	-1.0	0.2	-0.9
Crohns Disease (2012)	0.7	1.1	1.8	-1.0	-1.3	-1.2	-0.3
Hearing difficulty/problems: Yes	0.7	1.1	2.9	1.7	0.3	-0.8	-0.8
Medication: Metformin	0.7	1.1	2.4	0.8	0.4	1.6	-1.0
Stomach or abdominal pain in last month	0.7	0.9	1.5	1.2	0.7	-1.2	0.5
Medication: Levothyroxine sodium	0.7	1.1	2.0	1.4	0.8	-0.8	1.1
Trunk fat mass	0.7	3.2	8.1	2.0	0.8	2.9	0.3
Waist circumference	0.7	2.4	6.6	1.6	0.2	2.6	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.7	1.3	1.6	0.1	0.2
Hair/balding pattern: Pattern 3	0.7	1.0	3.4	0.2	-0.5	-1.8	-0.6
Number of live births	0.7	1.0	2.4	-0.3	0.3	1.5	-1.3
Pulse rate	0.7	1.1	2.4	1.5	0.5	-1.0	0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.7	-0.5	-1.1	0.2	-2.2
Prospective memory result	0.7	0.9	1.3	-0.8	-0.7	1.0	-1.2
Exposure to tobacco smoke at home	0.7	0.8	1.4	0.8	-0.6	1.2	0.9
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.5	1.6	0.0	-0.2	1.0
Body fat percentage	0.7	2.6	7.8	1.5	0.6	2.8	0.1
Whole body fat mass	0.7	3.1	7.9	2.0	0.6	2.8	0.2
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.7	-0.2	-0.4	0.7	-1.6
Back pain experienced in last month	0.7	1.1	1.6	0.9	1.0	-1.2	-0.9
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.7	1.0	0.5	-0.6	-1.3
Number of operations (self-reported)	0.7	1.0	1.9	1.3	0.6	1.4	-0.1
Leg fat mass (left)	0.7	2.7	5.2	2.2	0.9	2.3	-0.2
Crohns Disease (2017)	0.6	1.3	4.0	-2.0	-1.0	-0.4	0.2
Irritable Bowel Disease (IBD)	0.6	1.4	4.8	-2.2	-0.1	-0.5	-0.9
Triglycerides	0.6	0.9	1.7	-1.3	-0.8	0.4	-1.1
Ulcerative Colitis	0.6	0.9	1.4	0.3	0.9	-1.1	-1.2
BMI	0.6	3.4	11.0	1.5	0.3	3.3	-0.6
Systolic Blood Pressure	0.6	2.8	6.9	-2.6	-1.2	1.5	-0.8
Relative age of first facial hair	0.6	1.1	2.1	-1.0	-1.1	-1.5	-0.6
Trunk fat percentage	0.6	2.5	7.4	1.5	0.7	2.7	0.2
Average weekly fortified wine intake	0.6	0.8	1.3	0.9	1.1	0.5	-0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.4	1.2	0.8	0.6	0.6
Serious illness, injury or assault to yourself	0.6	0.7	2.4	-0.2	0.6	0.1	1.5
Hair/balding pattern: Pattern 2	0.6	0.8	1.9	-0.1	0.4	1.4	1.1
Medication: Ramipril	0.6	0.8	2.6	0.3	0.6	-0.0	1.6
Fluid intelligence score	0.6	1.3	3.8	-0.7	-0.1	1.0	1.9
Illnesses of siblings	0.6	0.8	1.7	-0.5	-1.3	-0.8	-0.8
Weight	0.6	2.8	5.5	2.4	1.3	2.1	-0.2
Arm fat percentage (right)	0.6	2.6	6.8	1.7	0.8	2.6	-0.0
Hip circumference	0.6	2.5	4.3	2.0	1.3	2.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.0	0.5	1.4	0.1	-0.7
Arm fat mass (right)	0.6	2.6	5.5	2.0	0.9	2.3	-0.2
Leg fat percentage (right)	0.6	2.3	5.6	1.7	0.8	2.4	0.2
Number of full brothers	0.6	0.8	1.4	1.2	0.5	-0.9	0.9
Arm fat percentage (left)	0.6	2.3	7.2	1.3	0.3	2.7	-0.2
Eye problems/disorders: Glaucoma	0.6	0.8	2.0	-0.1	-1.4	-0.9	-0.4
Medication: Bendroflumethiazide	0.6	0.9	2.5	-0.2	-0.3	1.6	-0.9
Alcohol drinker status: Never	0.6	0.7	1.3	-0.4	-0.3	-1.1	-1.1
Ever depressed for a whole week	0.6	0.8	2.2	-0.0	0.9	1.5	-0.2
Cholesterol lowering medication	0.6	0.9	1.8	-0.4	0.5	-1.3	1.1
Age at First Birth	0.5	0.7	1.9	0.4	1.4	-0.7	0.2
Heel T-Score	0.5	4.3	8.2	-2.9	0.4	2.3	-1.9
Height	0.5	9.2	16.8	3.4	2.5	1.6	4.1
Supplements: Zinc	0.5	0.5	0.9	-0.9	0.4	-0.9	0.3
Age when periods started (menarche)	0.5	1.2	2.2	1.5	-0.1	-1.2	1.2
Multivitamins +/- minerals	0.5	0.6	1.8	0.1	-0.5	-0.7	1.3
Body mass index (BMI)	0.5	1.9	4.2	1.5	0.6	2.1	-1.0
Pain all over the body in last month	0.5	0.5	0.9	-1.0	-0.2	0.9	-0.4
Depression (self-reported)	0.5	0.6	1.9	0.5	0.2	0.6	1.4
Medication: Lansoprazole	0.5	0.6	1.1	1.0	0.7	0.3	0.8
Pulse wave Arterial Stiffness index	0.5	0.6	1.2	-0.6	-0.1	-0.9	1.1
Medication: Paracetamol	0.5	0.9	1.7	1.2	0.4	-1.3	-0.6
Birth weight	0.5	1.1	3.5	-0.2	0.9	1.9	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.2	-1.1	-1.0	-0.1	-0.7
Number of children fathered	0.5	0.5	1.8	-0.5	-1.3	0.1	0.1
Pulse wave peak to peak time	0.5	0.6	1.0	0.8	0.4	0.7	-1.0
Medication: Allopurinol	0.5	0.6	1.6	0.7	1.3	-0.5	0.4
Family relationship satisfaction	0.5	0.6	1.6	1.3	0.8	-0.1	0.5
Supplements: Vitamin C	0.5	0.6	2.2	-0.3	0.3	-1.5	-0.2
Qualifications: nursing, teaching	0.5	0.8	1.6	0.7	1.3	-0.9	-0.5
Arm fat mass (left)	0.5	2.2	4.9	1.8	0.7	2.2	-0.2
Medication: Lisinopril	0.5	0.7	1.4	0.6	0.2	0.9	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.5	0.4	0.3	-0.8	1.2
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.6	-0.8	0.4	1.0	1.6
Coronary Artery Disease (CAD)	0.4	0.5	0.8	0.1	-0.8	-0.8	0.9
Lung FVC	0.4	1.9	4.2	-1.7	0.4	0.6	-2.1
Neuroticism	0.4	0.9	2.1	0.3	0.2	1.1	1.4
Diabetes (mother)	0.4	0.5	0.8	0.9	-0.1	-0.7	0.9
Pack years adult smoking proportion	0.4	0.6	1.3	-0.6	0.0	1.1	0.8
Relative age voice broke	0.4	0.5	1.7	0.3	-0.6	-1.3	0.1
Taking other prescription medications	0.4	0.5	1.8	0.0	0.0	0.6	1.3
Nervous feelings	0.4	0.8	2.6	-0.6	-0.1	-0.2	1.6
Medication: Simvastatin	0.4	0.6	1.0	-0.8	-0.2	0.8	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.4	0.2	0.7	0.8	-1.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.2	1.2	1.5	-0.4	-1.1
Tense / ‘highly strung’	0.4	0.6	1.9	-0.1	-1.4	-0.1	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.8	0.0	-0.8	0.2	1.4
Hair/balding pattern: Pattern 4	0.4	1.0	2.9	1.0	1.7	0.5	-0.3
Headache pain in last month	0.4	0.7	1.7	0.4	1.3	-0.8	-0.6
Gout (self-reported)	0.4	0.5	1.5	-0.1	0.1	-0.8	1.2
Neck or shoulder pain in last month	0.4	0.5	1.3	1.1	-0.5	-0.7	-0.1
Mean time to correctly identify matches	0.4	0.7	1.9	-1.4	-0.6	-0.5	0.7
Comparative height size at age 10	0.4	2.1	4.2	2.0	1.4	-0.3	1.4
Number of full sisters	0.4	0.5	1.0	0.6	1.0	-0.1	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	1.0	-0.1	-0.9	-0.1
Illnesses of siblings: Diabetes	0.4	0.5	1.3	0.7	1.1	0.4	-0.0
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	-0.5	1.1	-0.2	-0.6
Hearing aid user	0.4	0.5	0.8	-0.6	-0.7	0.5	0.9
Leg fat percentage (left)	0.4	1.6	3.1	1.6	0.7	1.8	0.1
Arm fat-free mass (left)	0.4	2.1	5.9	2.4	1.5	0.4	0.0
Pack years of smoking	0.4	0.6	1.7	-0.7	0.1	1.3	0.4
Arm predicted mass (left)	0.4	1.9	5.6	2.4	1.4	0.5	0.0
Neuroticism (Nagel 2018)	0.3	0.7	1.4	0.4	0.8	0.7	1.2
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.8	-0.3	-0.2	0.5	1.7
HDL Cholesterol	0.3	0.6	1.1	-0.6	0.5	1.0	0.7
LDL Cholesterol	0.3	0.4	0.9	-0.7	-0.9	-0.6	0.1
Blood White Count	0.3	2.1	4.6	-0.3	0.4	2.1	1.9
Allergy or Eczema	0.3	0.7	1.5	-1.0	-1.2	0.0	-0.6
Chronotype (morning person)	0.3	0.7	2.5	-0.3	-0.1	1.6	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	0.2	0.1	-0.5	1.1
Leg fat-free mass (left)	0.3	1.7	3.5	1.9	0.4	1.6	-0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	0.5	-0.2	-0.9	-0.6
Sitting height	0.3	2.3	3.9	1.3	0.3	-1.9	2.0
Impedance of leg (left)	0.3	1.2	2.4	-0.9	0.6	-1.1	1.6
Leg predicted mass (left)	0.3	1.7	3.2	1.8	0.3	1.8	-0.6
Trunk fat-free mass	0.3	1.5	4.4	2.1	1.0	0.7	0.2
Falls in the last year	0.3	0.4	0.8	-0.7	-0.9	-0.0	0.6
Asthma	0.3	0.6	1.9	0.4	1.4	-0.4	0.2
Trunk predicted mass	0.3	1.5	4.3	2.1	1.1	0.7	0.3
Standing height	0.3	3.2	5.9	2.4	1.9	0.1	1.7
Peak expiratory flow (PEF)	0.3	0.7	1.6	0.4	-0.1	-1.0	-1.2
Arm fat-free mass (right)	0.3	1.4	4.1	2.0	0.9	0.6	-0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	0.2	0.7	0.5	0.7
Asthma (self-reported)	0.3	0.6	1.6	0.2	1.3	-0.9	0.3
Whole body water mass	0.3	1.5	4.4	2.1	0.9	0.9	-0.1
Medication: Blood pressure	0.3	0.5	0.9	-0.3	0.9	0.7	0.8
Medication: Paracetamol	0.3	0.5	1.5	-0.1	0.1	-0.5	-1.2
Basal metabolic rate	0.3	1.7	4.9	2.2	0.9	1.1	-0.1
Fractured/broken bones in last 5 years	0.3	0.4	1.1	0.7	1.1	0.3	-0.2
Unable to work because of sickness or disability	0.3	0.5	1.7	-0.1	0.3	1.3	-0.1
Ovarian Cancer	0.2	0.2	0.3	0.5	-0.4	-0.5	-0.4
Blood Eosinophil Count	0.2	1.9	4.0	-0.8	-1.4	-1.0	2.0
Waist Hip Ratio (WHR)	0.2	1.1	3.2	-0.7	-1.8	0.7	0.4
Hypothyroidism (self reported)	0.2	0.5	1.1	0.8	-1.1	-0.2	-0.1
Respiratory disease	0.2	0.5	1.1	0.7	0.7	-0.1	1.1
Lung FEV1/FVC ratio	0.2	0.8	1.7	1.3	0.9	0.7	-0.0
Hand grip strength (left)	0.2	0.6	1.5	0.5	1.2	0.3	0.7
Impedance of leg (right)	0.2	0.8	2.4	-0.8	0.4	-0.3	1.5
Hand grip strength (right)	0.2	0.4	0.9	0.5	0.6	-0.4	1.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	-0.7	-1.1	0.1	-0.2
Number of incorrect matches in round	0.2	0.3	0.7	-0.3	0.3	-0.4	-0.9
Forced vital capacity (FVC)	0.2	0.7	1.6	0.8	1.3	0.3	-0.8
Allergy	0.2	0.5	0.9	0.5	0.0	-0.8	-0.9
Time employed in main current job	0.2	0.3	0.8	0.5	-0.1	0.3	-0.9
High blood pressure (siblings)	0.2	0.3	0.8	-0.6	0.4	0.9	0.0
Qualifications: College or University degree	0.2	0.6	1.1	-1.1	-0.5	-0.2	-1.0
Medication for pain relief, constipation, heartburn	0.2	0.3	1.1	0.3	1.0	-0.2	-0.3
Medication: Ibuprofen	0.2	0.2	0.6	-0.0	-0.8	0.3	-0.5
Arm predicted mass (right)	0.2	1.1	3.5	1.9	0.8	0.7	-0.2
Suffer from ‘nerves’	0.2	0.3	0.4	-0.6	0.5	0.4	0.6
Had major operations	0.2	0.2	0.4	-0.1	-0.6	0.6	0.2
Age at last live birth	0.2	0.3	0.8	0.9	0.2	-0.4	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	0.3	-0.3	-0.7	-0.5
Illnesses of father: Heart disease	0.2	0.3	0.7	0.3	-0.8	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.2	0.1	1.1	-0.5	0.1
Whole body fat-free mass	0.2	1.4	4.1	2.0	0.8	1.0	-0.0
Leg fat-free mass (right)	0.2	1.1	2.6	1.6	0.3	1.1	-0.7
Friendships satisfaction	0.2	0.2	0.5	0.3	-0.2	-0.3	0.7
Breast cancer (self-reported)	0.2	0.3	0.6	-0.6	-0.8	-0.5	-0.1
Osteoporosis (self-reported)	0.2	0.2	0.6	0.4	0.5	0.1	-0.7
Osteoarthritis (self-reported)	0.2	0.2	0.7	0.2	-0.3	0.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.6	0.3	0.6	-0.1	-1.3
Leg predicted mass (right)	0.2	1.1	2.8	1.7	0.3	1.1	-0.7
Illnesses of father: High blood pressure	0.2	0.3	0.5	-0.1	-0.7	-0.2	-0.7
Irritability	0.2	0.3	0.8	0.5	-0.3	-0.9	0.2
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	-0.0	0.3	-0.5	-0.7
Blood Platelet Count	0.1	1.0	2.4	0.4	1.6	-1.0	-0.5
Hearing difficulty/problems with background noise	0.1	0.2	0.4	-0.6	-0.2	0.6	-0.1
Neuroticism score	0.1	0.3	1.1	-0.2	-0.0	0.3	1.0
Impedance of arm (right)	0.1	0.5	1.2	-0.4	0.4	0.7	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	0.6	-0.2	-0.2	-0.4
Illnesses of mother	0.1	0.1	0.3	-0.3	-0.5	0.2	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.0	0.1	0.6	0.2	-1.0
Impedance of arm (left)	0.1	0.6	1.1	-1.1	-0.5	0.3	1.0
Birth weight of first child	0.1	0.2	0.3	-0.4	-0.6	0.4	0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.9	1.0	-0.2	-0.2	-0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	-0.0	0.5	0.0	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.2	0.4	-0.5	0.3	0.6	-0.4
Worry too long after embarrassment	0.1	0.2	0.2	-0.4	0.3	-0.4	-0.4
Age at first live birth	0.1	0.2	0.3	0.2	0.3	-0.5	0.6
Pulse rate, automated reading	0.1	0.5	0.7	0.8	-0.5	-0.8	0.6
Impedance of whole body	0.1	0.6	1.4	-0.8	0.1	-0.6	1.2
Hair Pigment	0.0	0.1	0.2	-0.5	-0.3	0.3	0.1
Tanning	0.0	0.5	2.0	-0.2	0.1	1.4	0.1
Length of working week for main job	0.0	0.1	0.1	-0.3	-0.3	0.1	-0.1

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