Best TWAS P=1.39e-10 · Best GWAS P=4.76e-11 conditioned to 0.202
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NOB1 | 0.04 | 0.05 | enet | 12 | 0.04 | 7.2e-06 | 5.8 | -6.4 | 1.4e-10 | -0.54 | 0.25 | 0.74 | TRUE |
| 2 | GTEx | Brain Cerebellum | NOB1 | 0.15 | 0.08 | lasso | 3 | 0.07 | 3.7e-03 | 5.5 | -5.9 | 3.6e-09 | -0.49 | 0.08 | 0.30 | FALSE |
| 3 | GTEx | Brain Cerebellum | CTD-2033A16.3 | 0.14 | 0.15 | lasso | 4 | 0.12 | 2.2e-04 | 6.0 | -6.1 | 9.8e-10 | -0.46 | 0.10 | 0.47 | FALSE |
| 4 | GTEx | Esophagus Mucosa | PDXDC2P | 0.39 | 0.22 | lasso | 6 | 0.23 | 1.6e-15 | 6.5 | 6.2 | 6.7e-10 | 0.95 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Testis | PDXDC2P | 0.62 | 0.50 | enet | 15 | 0.57 | 6.8e-30 | 6.5 | 5.9 | 3.8e-09 | 0.92 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Whole Blood | PDXDC2P | 0.16 | 0.05 | lasso | 3 | 0.07 | 9.0e-07 | 6.6 | 5.9 | 4.8e-09 | 0.84 | 0.00 | 1.00 | TRUE |
| 7 | METSIM | Adipose | NOB1 | 0.03 | 0.03 | lasso | 2 | 0.03 | 2.8e-05 | 6.1 | -5.9 | 4.3e-09 | -0.56 | 0.14 | 0.83 | FALSE |
| 8 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PDXDC2 | 0.20 | 0.02 | blup | 26 | 0.07 | 1.8e-04 | -2.3 | -5.5 | 3.5e-08 | -0.77 | 0.02 | 0.80 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | CLEC18C | 0.06 | 0.02 | lasso | 2 | 0.02 | 6.6e-04 | 5.8 | -5.9 | 3.8e-09 | -0.84 | 0.01 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | CLEC18C | 0.05 | 0.04 | lasso | 3 | 0.04 | 1.6e-04 | -3.8 | -5.1 | 2.9e-07 | -0.75 | 0.04 | 0.40 | FALSE |