TWAS hub - HAX1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0990	0.0400	6.2e-05	0.070	0.048	0.073	0.080	0.073	6.3e-09	1.5e-06	3.0e-09	5.1e-10	3.2e-09
2	GTEx	Artery Aorta	0.1670	0.0790	8.3e-03	0.023	NA	0.016	NA	0.027	1.9e-02	NA	4.4e-02	NA	1.2e-02
3	GTEx	Artery Tibial	0.2277	0.0651	7.3e-07	0.079	NA	0.067	NA	0.080	8.7e-07	NA	5.9e-06	NA	7.3e-07
4	GTEx	Brain Putamen basal ganglia	0.2720	0.1040	5.5e-03	-0.010	NA	-0.007	NA	-0.008	6.5e-01	NA	5.0e-01	NA	5.6e-01
5	GTEx	Esophagus Mucosa	0.0730	0.0360	8.7e-03	0.022	NA	-0.003	NA	-0.003	1.2e-02	NA	6.1e-01	NA	5.7e-01
6	GTEx	Esophagus Muscularis	0.1210	0.0450	5.8e-04	0.102	NA	0.065	NA	0.093	9.4e-07	NA	8.8e-05	NA	2.7e-06
7	GTEx	Heart Left Ventricle	0.0918	0.0440	7.9e-03	0.033	NA	0.030	NA	0.040	7.1e-03	NA	9.7e-03	NA	3.2e-03
8	METSIM	Adipose	0.0365	0.0220	1.6e-02	0.000	0.005	0.004	0.006	0.001	2.8e-01	4.6e-02	6.8e-02	3.3e-02	2.5e-01
9	YFS	Blood	0.0312	0.0119	2.6e-06	0.009	0.022	0.022	0.025	0.014	4.6e-04	9.2e-08	5.5e-08	1.2e-08	1.4e-05
10	TCGA	Breast Invasive Carcinoma	0.0228	0.0133	8.3e-03	0.017	0.010	0.007	NA	0.011	1.5e-04	3.6e-03	1.1e-02	NA	2.3e-03
11	TCGA	Lung Squamous Cell Carcinoma	0.0630	0.0319	6.6e-03	0.007	0.019	0.015	NA	0.003	5.3e-02	2.5e-03	7.5e-03	NA	1.2e-01
12	TCGA	Thyroid Carcinoma	0.0910	0.0400	5.3e-04	0.021	0.007	0.059	NA	0.001	3.8e-03	6.0e-02	1.9e-06	NA	2.6e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Smoking Status	10.3	24.7	47.0	-4.5	-5.9	-5.9	-5.3	0.7	-5.5	-5.2	-5.9	-6.9	-0.8	-3.2	-5.4
Supplements: Calcium	6.1	6.7	15.6	2.5	3.9	3.3	4.0	0.0	2.4	3.5	1.3	2.0	0.5	1.7	2.5
Major Depression (MDD)	6.0	7.3	13.8	-2.3	-3.1	-2.5	-2.2	-1.3	-3.7	-3.3	-2.4	-3.4	-3.2	0.9	-2.5
Past tobacco smoking	6.0	11.0	19.7	1.3	4.3	4.4	3.1	-1.5	3.9	3.4	4.3	4.3	-0.2	2.9	2.8
Smoking status: Previous	5.2	7.8	15.8	-0.9	-3.6	-4.0	-2.6	1.6	-3.5	-3.0	-3.5	-3.4	0.1	-2.5	-2.1
Ever smoked	5.2	9.1	19.9	-0.7	-3.8	-4.1	-2.3	1.5	-3.7	-3.2	-4.5	-3.9	0.3	-2.3	-2.3
Triglycerides	4.8	7.8	12.7	-2.8	-3.0	-2.6	-3.1	-1.5	-2.7	-3.6	-2.7	-3.3	-2.5	-1.2	-3.5
Migraine (self-reported)	4.7	5.8	17.1	-2.9	-0.8	-1.3	-2.9	0.2	-1.2	-1.9	-2.9	-2.7	-0.3	-4.1	-3.5
Age at First Birth	4.6	6.7	16.2	3.2	1.8	2.5	3.7	1.1	3.0	4.0	-0.0	3.0	2.5	0.5	2.5
Alzheimer’s Disease (in father)	4.5	4.9	10.6	-3.2	-2.1	-1.7	-0.9	-0.9	-2.4	-2.6	-2.7	-3.0	-1.8	-0.7	-2.7
Age at first live birth	4.4	7.9	17.6	4.2	2.3	2.6	3.0	1.6	2.9	3.2	1.3	3.5	2.1	2.0	3.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.3	5.2	11.4	-2.1	-2.6	-3.0	-2.3	-0.4	-3.4	-2.9	0.1	-3.2	-1.6	-0.4	-1.9
Loud music exposure frequency	4.2	4.6	8.5	-2.6	-1.6	-1.4	-1.1	-1.5	-2.2	-2.6	-2.6	-2.3	-2.7	-0.7	-2.9
Age started oral contraceptive pill	4.2	5.3	12.3	1.2	2.6	3.5	2.0	-0.1	3.2	3.1	2.0	1.9	1.8	1.6	2.4
Medication: Ventolin 100micrograms inhaler	4.1	5.2	10.4	-1.7	-3.1	-2.7	-2.6	-0.6	-2.6	-3.2	0.3	-2.6	-2.8	1.2	-1.6
Mouth/teeth dental problems	4.0	6.1	13.4	-1.9	-1.7	-1.8	-1.7	-3.4	-3.3	-3.4	-0.5	-2.4	-3.7	1.0	-2.4
Exposure to tobacco smoke at home	3.7	4.1	7.5	-2.1	-2.1	-2.7	-1.4	0.1	-2.4	-2.2	-1.7	-2.3	-1.5	-1.8	-2.6
Medication: Bendroflumethiazide	3.7	5.7	12.5	1.7	2.9	2.7	2.6	0.6	3.2	3.5	1.6	2.3	2.6	-0.1	2.3
HDL Cholesterol	3.6	6.0	16.3	4.0	1.6	1.8	2.2	1.9	2.0	2.8	0.8	3.3	2.6	0.4	3.3
Prostate Cancer	3.5	5.0	15.1	-1.2	-0.7	-1.9	-2.0	-3.2	-2.5	-3.9	-1.6	-2.1	-2.8	1.8	-1.2
Hayfever, allergic rhinitis or eczema	3.3	7.1	17.7	-1.6	-4.1	-3.8	-1.8	0.4	-3.1	-4.2	-1.1	-3.1	-2.8	0.2	-1.8
Irritability	3.3	5.6	11.2	1.9	3.1	3.0	3.3	-0.0	3.2	2.7	0.1	2.2	0.9	2.1	2.7
Intelligence (Savage-Jansen 2018)	3.2	9.7	21.0	4.3	2.0	2.5	4.6	2.2	2.9	3.5	-0.6	3.7	1.6	2.7	4.2
Schizophrenia vs Biploar Disorder	3.2	4.2	8.0	-1.2	-2.5	-2.8	-1.9	0.6	-2.6	-2.5	-1.2	-1.7	-1.8	-1.8	-2.7
Nervous feelings	3.2	6.0	24.5	-3.6	2.2	0.8	0.7	-4.9	-0.2	-1.5	-1.2	-2.0	-3.6	0.9	-2.6
Mouth/teeth dental problems: Bleeding gums	3.2	4.2	15.5	2.0	0.2	0.3	0.2	3.6	2.3	1.8	-0.9	1.5	3.9	-0.1	2.4
Ever unenthusiastic/disinterested for a whole week	3.1	3.8	8.9	-1.3	-2.6	-2.4	-0.9	-0.5	-3.0	-2.3	-2.8	-2.4	-1.1	-0.1	-1.4
Headache pain in last month	3.0	5.1	12.0	-2.4	-1.0	-2.7	-0.8	-1.7	-3.5	-2.4	-0.7	-2.7	-3.2	-1.1	-2.6
Eye problems/disorders: Cataract	2.9	3.4	7.7	0.7	2.8	2.5	0.4	-0.0	2.7	1.8	2.1	1.8	1.8	-0.1	2.0
Crohns Disease (2017)	2.8	6.1	13.4	1.4	3.0	2.9	1.5	-0.6	3.3	3.7	1.3	1.7	2.8	2.5	2.6
Blood clot in the leg (DVT)	2.8	3.6	13.8	1.0	2.6	2.4	1.8	0.1	1.6	1.8	3.7	2.0	-0.0	0.2	1.7
Deep venous thrombosis (DVT) (self-reported)	2.8	3.6	13.5	1.2	2.4	2.3	1.8	0.3	1.7	1.9	3.7	1.9	0.3	0.3	1.8
Suffer from ‘nerves’	2.7	4.3	12.0	-3.1	1.4	0.1	-0.6	-3.3	-1.2	-1.6	-0.3	-2.3	-3.5	0.5	-2.4
Noisy workplace	2.6	3.2	9.5	-2.6	-0.8	0.0	-1.7	-2.0	-1.3	-1.9	2.4	-0.6	-3.1	1.5	-1.2
Mouth/teeth dental problems: Dentures	2.6	4.3	11.5	0.8	2.4	2.6	1.1	0.9	3.1	3.4	1.7	2.1	2.2	-1.4	1.4
Diabetes (mother)	2.5	3.2	7.9	1.9	0.9	1.1	1.1	2.8	2.1	2.4	0.8	1.4	2.6	-0.1	1.9
Current tobacco smoking	2.5	4.1	10.7	-2.7	-2.0	-1.8	-2.3	0.4	-1.7	-1.9	-2.4	-3.3	0.3	-0.9	-2.4
Diabetes (self-reported)	2.5	3.9	7.3	1.1	2.3	2.6	2.3	0.0	2.7	2.0	1.0	1.8	2.6	-0.3	2.3
Fractured/broken bones in last 5 years	2.5	3.2	8.3	0.6	2.2	2.7	1.1	-0.2	2.2	2.2	2.9	2.0	1.0	-0.3	1.2
Pain experienced in last month	2.5	4.2	13.0	2.0	1.2	1.8	1.8	2.1	2.8	2.5	-0.5	1.6	3.6	-0.4	2.2
Medication: Metformin	2.4	3.3	7.1	0.9	2.7	2.6	2.2	-0.8	2.4	2.5	0.9	1.5	1.2	0.4	1.8
Breastfed as a baby	2.4	3.0	6.8	1.9	1.8	2.0	1.4	1.4	1.4	2.6	1.8	1.8	0.6	1.0	2.1
Medication: Blood pressure	2.4	4.2	9.0	2.1	2.2	2.3	2.0	0.9	3.0	2.8	-0.5	1.7	2.7	0.0	2.0
Worry (Nagel 2018)	2.3	4.9	16.9	-2.6	2.6	1.8	1.7	-4.1	0.2	-0.7	0.4	-1.0	-3.7	2.3	-1.3
Age when periods started (menarche)	2.3	5.5	14.2	1.4	1.4	2.2	0.3	2.1	2.7	2.4	3.3	2.1	3.8	-2.6	1.8
Allergy	2.3	5.3	18.1	1.2	2.9	2.2	1.3	1.0	2.4	4.3	-0.3	2.4	3.5	-1.6	0.9
Hayfever/allergic rhinitis (self-reported)	2.3	3.0	7.3	-2.0	-2.7	-1.7	-1.3	-1.1	-1.7	-2.3	-0.8	-2.0	-2.0	0.8	-1.2
Age at last live birth	2.3	3.3	7.9	2.8	1.1	1.6	1.7	1.5	1.6	2.1	2.2	2.5	0.6	0.9	1.7
Smoking status: Current	2.3	3.7	9.7	-2.5	-1.9	-1.7	-2.0	0.1	-1.8	-1.7	-2.1	-3.1	-0.0	-1.0	-2.5
Average weekly fortified wine intake	2.2	2.6	9.0	0.8	2.9	2.0	0.6	-1.3	1.6	0.6	3.0	1.5	-0.6	0.5	1.2
Forced vital capacity (FVC), Best measure	2.2	8.2	18.2	-2.1	-4.0	-3.7	-4.3	1.6	-3.3	-2.6	-1.8	-2.3	0.2	-2.8	-3.1
Medication for hormone replacement therapy	2.1	2.4	7.7	-2.3	0.8	-0.3	0.1	-2.8	-1.0	-0.7	-0.2	-1.9	-2.5	0.7	-1.6
Number of live births	2.1	2.9	5.2	-2.0	-0.7	-0.9	-2.2	-0.8	-2.0	-2.1	1.4	-1.6	-2.3	-1.3	-2.1
Illnesses of father: Heart disease	2.1	2.9	7.7	1.1	2.8	2.0	2.3	-2.2	1.6	1.9	-0.1	2.2	0.0	0.6	0.6
Bipolar Disorder (2018)	2.0	3.2	10.2	0.9	0.7	2.3	2.4	0.4	1.9	1.0	3.2	1.5	-0.6	2.1	1.9
Frequency of depressed mood in last 2 weeks	2.0	2.7	10.0	-1.9	0.8	-1.1	-0.3	-3.2	-1.4	-1.2	-1.6	-1.9	-2.2	0.4	-1.7
Vascular/heart problems diagnosed by doctor	2.0	5.5	13.0	-2.4	-2.3	-2.0	-2.6	-1.8	-3.0	-3.6	0.3	-2.4	-2.9	1.5	-1.5
Alzheimer’s Disease (including proxy)	1.9	2.8	5.7	-2.4	-2.0	-1.6	-1.8	-0.2	-1.6	-2.1	-1.6	-2.1	-1.1	-0.4	-1.7
Impedance of leg (left)	1.9	9.2	13.8	-3.0	-3.5	-3.2	-3.2	-0.7	-3.7	-3.7	-2.2	-3.5	-1.3	-2.9	-3.6
Alcohol usually taken with meals	1.9	3.0	9.4	0.2	2.9	2.1	3.1	-1.5	1.1	1.9	1.8	1.3	-0.9	0.9	0.8
Forced vital capacity (FVC)	1.9	7.5	16.7	-1.6	-3.4	-3.6	-4.1	1.2	-3.3	-2.6	-1.8	-2.5	0.4	-3.0	-3.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.0	11.8	-1.5	-3.4	-3.4	-3.1	1.0	-3.4	-2.3	-1.3	-1.5	-0.5	-2.5	-2.8
LDL Cholesterol	1.8	2.9	8.6	-1.9	-0.9	-1.2	0.5	-1.7	-1.9	-2.2	-1.0	-1.7	-2.9	0.0	-2.3
Diverticular disease/diverticulitis (self-reported)	1.8	2.2	5.6	-1.5	-0.7	-0.4	-1.9	-2.1	-1.3	-1.7	-0.2	-2.4	-1.4	-0.2	-1.8
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	6.6	-1.8	-1.4	-2.1	-1.1	-0.7	-2.1	-1.3	-2.6	-2.3	-1.3	-0.7	-1.7
Medication: Aspirin	1.8	2.3	4.2	1.6	0.6	1.0	1.4	1.6	1.9	2.0	1.8	1.2	2.0	-0.7	1.4
Guilty feelings	1.8	2.7	8.4	-1.9	-0.7	-0.7	0.3	-2.2	-1.5	-1.5	-1.8	-1.6	-2.9	0.9	-2.1
Bipolar Disorder or Schizophrenia	1.7	4.2	16.3	0.4	0.7	2.4	2.7	-0.6	1.0	0.1	4.0	1.1	-2.4	3.1	1.5
Allergy or Eczema	1.7	4.5	14.7	-0.5	-3.2	-3.0	-1.1	0.2	-2.5	-3.8	0.1	-1.8	-2.8	-0.1	-1.2
High blood pressure	1.7	4.9	10.3	2.2	2.3	2.0	2.3	1.8	3.2	3.2	-0.2	2.3	2.6	-1.3	1.3
Falls in the last year	1.7	2.3	5.0	0.8	1.7	1.7	2.2	-0.1	1.6	2.0	1.4	1.9	-0.2	1.6	1.3
Hair/balding pattern: Pattern 4	1.7	4.1	9.0	1.4	1.1	1.5	2.7	1.8	2.7	3.0	0.3	2.5	2.8	-0.7	1.7
Hypertension (Self-reported)	1.7	4.8	10.4	2.2	2.5	2.1	2.6	1.6	3.2	3.0	-0.3	2.2	2.4	-1.4	1.2
Neuroticism score	1.6	3.3	15.8	-1.0	2.4	1.5	1.6	-4.0	0.8	-0.1	-0.9	0.0	-2.3	2.3	-0.4
Tense / ‘highly strung’	1.6	2.6	8.2	-2.5	2.3	1.6	0.5	-2.3	0.8	-0.4	1.1	-0.4	-2.9	0.9	-0.6
Qualifications: College or University degree	1.6	5.0	16.5	4.1	0.6	1.2	2.6	1.7	1.6	2.0	0.4	3.0	0.6	2.7	2.8
Mean time to correctly identify matches	1.6	3.1	6.0	1.7	2.0	1.5	1.0	1.8	2.0	2.3	1.2	1.9	1.6	1.0	2.5
Average weekly red wine intake	1.6	2.4	5.6	2.3	0.8	0.8	2.1	0.1	0.7	1.7	1.0	2.0	0.3	2.4	1.9
Tinnitus: Yes, now most or all of the time	1.6	1.9	5.8	-2.4	-1.4	-1.0	-1.3	-0.6	-0.8	-0.7	-0.9	-1.9	-0.6	-1.2	-2.1
Medication: Paracetamol	1.6	2.4	8.2	-1.7	-0.5	-0.7	0.1	-1.3	-1.6	-2.2	0.4	-1.5	-2.9	-1.6	-1.9
Reaction Time	1.5	2.8	6.9	2.4	1.0	0.7	0.5	2.4	1.3	1.5	1.0	2.0	1.6	1.4	2.6
Neuroticism	1.5	3.7	14.7	-0.9	2.4	2.0	1.7	-3.8	1.4	0.2	-1.2	0.2	-1.8	3.1	0.2
Average weekly spirits intake	1.5	1.8	4.2	-0.7	2.0	1.7	0.1	0.1	1.5	1.8	2.0	1.2	1.2	-1.4	0.2
Systolic blood pressure, automated reading	1.5	4.2	12.0	0.9	2.7	3.1	3.5	-1.2	2.2	2.3	1.1	2.4	-0.0	0.9	1.3
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	4.5	-0.4	1.9	2.0	0.2	-2.1	1.9	0.1	1.2	1.2	-0.6	-0.2	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	3.0	1.4	1.6	1.5	1.1	0.7	1.7	1.7	0.5	0.8	1.6	1.0	1.5
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	7.0	-0.9	-2.1	-1.6	-1.6	-0.0	-2.4	-2.0	0.7	-0.8	-2.6	1.0	-0.8
Ever taken oral contraceptive pill	1.5	1.7	5.0	-0.3	1.9	2.2	-1.0	-1.9	1.4	-0.3	1.8	1.2	-0.5	-0.0	0.1
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	4.7	-1.8	2.2	2.1	-0.6	-1.6	0.9	0.7	2.1	-0.2	-0.6	0.3	-0.2
Diabetes (father)	1.4	1.7	3.5	0.6	1.6	1.9	0.0	0.9	1.9	1.6	1.1	1.8	0.5	-1.3	0.8
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	4.8	-1.2	-1.5	-1.3	-0.4	0.3	-1.0	-0.2	-2.2	-0.9	-0.6	-1.7	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	5.1	-1.2	-1.2	-0.6	-1.1	0.1	-1.4	-0.6	-2.3	-0.8	-0.7	-1.7	-1.9
Impedance of whole body	1.4	6.9	19.2	-2.5	-2.5	-2.3	-2.6	-1.8	-3.1	-4.4	-0.7	-2.4	-2.1	-2.5	-3.1
Irritable Bowel Disease (IBD)	1.3	3.0	6.1	0.7	1.9	2.0	0.6	0.4	2.2	2.5	1.1	0.8	2.1	2.2	2.2
Primary Biliary Cirrhosis	1.3	1.9	4.6	0.5	1.1	1.8	1.9	-0.3	2.1	1.4	1.1	1.0	0.2	1.8	1.4
Hand grip strength (left)	1.3	3.3	11.4	-0.1	-2.4	-2.1	-3.4	1.8	-1.7	-2.6	1.2	-1.4	0.6	-0.8	-1.0
Comparative body size at age 10	1.3	3.5	8.0	1.2	1.6	2.0	2.4	1.2	1.9	2.8	-0.1	2.0	2.4	1.4	1.9
Heart disease (mother)	1.3	1.6	6.9	-0.6	1.2	1.5	0.6	0.7	1.7	1.0	2.6	0.9	-0.1	-1.7	-0.2
Comparative height size at age 10	1.3	7.1	11.5	-2.8	-3.2	-3.0	-2.8	-0.2	-3.2	-3.2	1.4	-3.4	-2.6	-1.2	-2.9
Breast cancer (self-reported)	1.3	1.6	4.0	-0.7	-1.9	-1.5	-1.7	0.7	-2.0	-0.7	-1.4	-1.3	-0.4	-0.6	-0.7
Asthma (self-reported)	1.3	2.5	8.3	-1.0	-1.3	-0.9	-1.1	-1.2	-1.0	-2.9	0.6	-1.6	-2.9	1.6	-0.8
Commuting to job workplace: Public transport	1.3	1.6	5.8	-0.9	-0.7	-1.7	0.0	-0.7	-2.3	-0.9	-2.4	-1.3	-0.1	0.4	-0.7
Heart attack/myocardial infarction (self-reported)	1.3	1.7	4.2	1.7	1.3	0.9	1.9	-0.1	0.1	2.1	1.3	1.9	0.6	-0.5	0.9
Depression (Nagel 2018)	1.2	1.7	4.1	-2.0	-0.2	-1.5	-0.7	-2.0	-1.7	-0.4	-1.3	-1.6	-1.2	0.8	-0.9
Neuroticism (Nagel 2018)	1.2	2.9	8.5	-0.8	2.2	1.3	2.4	-2.9	0.6	0.1	-0.6	0.3	-2.1	2.9	0.2
Crohns Disease (2012)	1.2	2.0	5.2	-0.3	2.3	1.7	1.5	-1.4	1.8	2.0	0.5	0.2	0.6	1.4	1.0
Fasting Glucose	1.2	1.4	3.2	-1.7	0.9	0.5	-1.0	-1.6	-0.3	-0.3	1.4	-0.2	-1.4	-1.8	-1.5
Schizophrenia (2014)	1.2	2.6	7.6	0.4	0.6	1.3	1.8	-1.3	0.5	-0.9	2.8	1.0	-2.7	2.7	0.8
Angina	1.2	1.5	6.0	1.1	0.3	0.2	-0.3	0.7	1.4	1.9	0.8	1.0	2.5	-1.8	0.7
Medication: Atenolol	1.2	1.5	6.8	0.4	0.6	0.8	1.3	0.6	1.4	1.6	0.5	1.1	1.5	-2.6	0.3
Hearing difficulty/problems with background noise	1.2	1.9	5.1	-0.4	-1.9	-1.6	-0.8	-0.3	-2.2	-2.2	-0.3	-1.8	-1.2	0.8	-0.8
Worrier / anxious feelings	1.2	2.2	12.4	-0.9	2.4	1.6	1.3	-3.5	1.2	-0.1	-0.5	0.2	-1.1	0.8	-0.4
Hair/balding pattern: Pattern 3	1.2	1.8	3.2	1.1	1.1	1.5	1.5	-0.2	1.6	1.5	-1.7	1.0	1.8	0.7	1.5
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	8.9	-0.8	-2.4	-2.9	-2.7	0.3	-3.0	-2.1	-0.9	-1.3	-0.4	-2.2	-2.3
Mood swings	1.2	2.3	7.5	0.5	2.7	1.6	2.3	-2.5	1.1	1.0	-0.2	0.8	-0.8	1.3	0.5
Loneliness, isolation	1.2	1.6	5.2	-1.4	0.3	-0.6	-0.2	-2.2	-0.9	-1.2	-1.4	-0.7	-2.3	1.4	-0.8
Back pain experienced in last month	1.2	1.7	3.7	-1.9	-0.1	-0.9	-0.6	-1.6	-1.4	-1.6	-0.1	-1.9	-1.7	0.3	-1.2
Mineral and other dietary supplements	1.2	1.6	6.3	-0.9	-0.3	-1.3	-1.8	-0.8	-0.8	-1.4	-2.5	-1.3	-0.1	-1.0	-1.0
Pain type(s) experienced in last month: Hip pain	1.2	1.6	5.3	-0.3	-1.3	-0.6	-2.3	0.4	-1.4	-1.8	1.3	-0.9	-1.6	0.9	-0.3
Alzheimer’s Disease (in mother)	1.1	1.3	3.5	-1.2	-1.5	-1.2	-1.9	0.2	-0.8	-1.2	-1.0	-1.5	-0.7	0.5	-0.6
Type 2 Diabetes (T2D) (2012)	1.1	1.3	4.4	-1.0	1.5	0.8	-1.6	0.3	1.0	1.5	-0.1	0.4	1.1	-2.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	2.7	-1.5	-0.6	-1.6	-0.5	-1.3	-1.5	-0.4	-1.6	-1.6	-0.9	1.1	-0.7
Relative age voice broke	1.1	1.7	4.6	1.2	0.5	0.8	0.4	2.1	1.5	1.9	1.2	1.0	1.7	-0.4	1.6
Multivitamins +/- minerals	1.1	1.4	7.4	0.9	0.7	0.9	1.5	0.5	0.6	0.9	2.7	1.3	-0.8	1.0	0.9
Stomach or abdominal pain in last month	1.1	1.4	3.4	-1.5	-0.5	-0.5	-0.7	-1.2	-1.4	-1.4	-0.2	-1.8	-1.6	-0.3	-1.5
Peak expiratory flow (PEF)	1.1	2.5	7.3	-0.8	-1.2	-2.1	-0.7	-1.4	-2.4	-2.7	-0.2	-1.1	-1.3	-0.9	-2.0
Pulse wave reflection index	1.1	1.4	4.0	1.0	-1.6	-0.9	0.1	2.0	-0.0	1.2	-1.8	0.8	1.5	-0.5	0.6
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	6.7	1.1	-1.4	-1.8	-1.4	0.1	-1.9	-0.8	-2.6	-0.9	-0.2	1.1	-0.1
Commuting to job workplace: Car/motor vehicle	1.1	1.2	4.7	0.8	0.8	1.7	0.5	-0.3	0.9	1.0	2.2	1.5	-1.0	-0.2	-0.3
Diabetes diagnosed by doctor	1.1	1.8	4.0	0.3	1.8	1.9	1.5	-0.3	2.0	0.9	0.9	1.2	1.6	-0.7	1.3
Illnesses of father: None of the above (group 1)	1.1	1.4	3.3	-0.2	-1.6	-1.3	-1.2	1.0	-1.3	-1.3	0.8	-1.0	-0.3	-1.8	-1.1
Hearing aid user	1.1	1.3	4.0	-1.1	-1.4	-1.5	-0.0	-0.4	-0.5	-1.2	-0.2	-0.8	0.5	-2.0	-1.7
Ever depressed for a whole week	1.1	1.4	4.6	-0.1	-1.4	-2.1	-0.4	0.6	-1.7	-0.9	-2.1	-1.2	0.3	-0.0	-0.1
Schizophrenia (2018)	1.0	2.1	7.0	-0.2	0.3	1.2	1.5	-1.1	-0.3	-0.6	2.6	0.2	-2.6	2.3	0.4
Supplements: Zinc	1.0	1.1	4.7	-0.6	0.1	0.6	-0.9	-1.6	-1.1	-0.8	-0.5	-0.7	-2.2	1.3	-0.4
Severe depression (siblings)	1.0	1.1	4.7	-0.7	-0.8	-0.8	-0.7	0.3	-1.2	-1.3	-2.2	-0.9	-0.6	-0.7	-1.2
Impedance of leg (right)	1.0	4.9	9.4	-2.0	-2.5	-2.2	-2.3	-0.5	-2.7	-3.1	-1.5	-2.5	-0.6	-2.3	-2.7
Serious illness, injury or assault to yourself	1.0	1.3	3.2	0.2	1.8	1.5	0.9	-0.5	0.8	1.7	1.3	0.3	-0.7	1.6	0.7
Heart attack	1.0	1.3	3.2	1.8	1.2	0.7	1.7	-0.3	0.0	1.7	1.0	1.8	0.3	-0.3	0.8
Qualifications: A levels/AS levels or equivalent	1.0	2.2	7.6	2.8	-0.4	-0.8	-0.5	2.2	0.0	0.7	-1.4	1.5	1.2	1.7	1.9
Asthma	1.0	2.0	7.6	-1.0	-1.1	-0.9	-0.6	-1.2	-0.8	-2.6	0.4	-1.4	-2.8	1.1	-0.9
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	12.1	0.2	-0.0	0.2	-0.7	0.1	-0.4	-0.2	3.5	0.7	-1.4	0.4	0.6
Prospective memory result	1.0	1.2	3.1	-0.8	0.1	0.2	-1.6	-1.8	-1.1	-1.2	1.7	-0.2	-1.6	0.0	-0.3
Medication: Paracetamol	1.0	1.6	6.2	-1.3	0.0	-0.2	0.2	-1.1	-1.1	-1.3	1.5	-0.7	-2.5	-1.8	-1.2
Number of full brothers	1.0	1.3	4.5	-0.1	-0.9	-1.6	-0.5	0.4	-2.1	-1.6	-1.4	-0.5	-1.2	-0.6	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.6	-1.9	-0.1	-0.3	-0.5	-1.6	-0.5	-0.6	-0.8	-1.5	-1.6	-0.0	-1.6
Wheeze or whistling in the chest in last year	1.0	1.8	7.6	-0.1	-1.4	-0.8	-0.7	-0.3	-0.8	-2.3	-0.0	-0.8	-1.9	2.8	0.6
Overall health rating	1.0	2.2	7.8	-2.3	-0.8	-1.6	-0.5	-0.9	-1.0	-1.6	-1.8	-2.8	-0.9	0.2	-1.2
Illnesses of siblings: Diabetes	1.0	1.3	4.0	0.3	1.0	1.4	-0.3	0.9	1.7	1.4	-0.2	1.1	1.1	-2.0	-0.1
Friendships satisfaction	1.0	1.2	3.5	0.5	-0.4	-0.5	1.1	-1.9	-0.5	-1.3	-1.8	-0.6	-0.6	1.7	-0.1
High cholesterol (Self-reported)	1.0	1.7	5.3	-1.4	-0.6	-0.9	-0.7	-0.6	-0.9	-0.7	-2.0	-1.2	0.0	-2.3	-2.0
Alcohol drinker status: Never	1.0	1.2	2.8	-1.7	-0.8	-1.2	-1.3	1.2	-0.4	-0.3	0.4	-1.2	-0.1	-1.6	-1.5
Commuting to job workplace: Cycle	1.0	1.3	10.6	-0.0	0.6	0.6	0.3	-1.2	0.3	0.2	0.7	-0.4	-0.6	3.2	1.1
Blood Platelet Count	0.9	9.9	27.2	-4.4	1.2	2.8	-2.0	-5.2	0.7	-4.3	1.1	-2.0	-4.9	3.0	-1.1
Type 2 Diabetes (T2D) (2018)	0.9	1.6	3.4	0.2	1.7	1.7	1.4	-0.5	1.8	0.9	-0.1	0.9	1.9	-1.5	0.9
Lung FVC	0.9	4.4	16.5	-0.1	-1.6	-1.7	-1.5	3.4	-0.9	1.2	-0.9	-0.2	3.6	-4.1	-0.8
Hearing difficulty/problems: Yes	0.9	1.3	6.6	0.9	0.7	0.4	2.1	0.2	0.3	-0.3	2.6	0.3	-0.8	1.5	0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.1	6.6	-0.8	1.2	0.4	0.7	-0.5	0.4	1.5	0.6	0.2	-0.0	-2.6	-1.1
Medication: Co-codamol	0.9	1.1	4.5	-1.9	0.5	0.8	0.8	-0.3	0.7	-0.3	0.6	-0.3	-2.1	-0.9	-1.1
Hand grip strength (right)	0.9	2.4	7.7	0.1	-2.3	-1.6	-2.8	1.9	-0.7	-1.6	1.2	-0.7	1.5	-1.2	-0.7
Maternal smoking around birth	0.9	1.3	4.2	-0.9	-1.4	-1.1	-1.8	0.9	-0.9	-0.9	-0.3	-2.0	0.1	-0.9	-1.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	4.8	-2.2	0.1	-0.0	-0.5	-1.1	-0.5	-0.0	-1.3	-1.3	-0.7	-0.9	-1.4
Number of incorrect matches in round	0.9	1.6	15.1	-0.3	1.1	0.7	-0.5	-0.2	-0.2	0.5	3.9	0.5	-0.1	0.7	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.4	-1.7	1.1	0.1	-0.3	-1.8	-0.5	-0.5	-1.5	-1.4	-1.6	-0.1	-1.4
Had menopause	0.9	1.1	4.2	-0.4	1.4	2.0	0.5	-0.5	1.4	1.4	0.6	0.6	0.4	-1.3	0.0
Fluid intelligence score	0.9	1.8	4.2	1.5	0.2	0.3	2.0	1.6	1.1	1.8	-1.6	1.0	1.7	0.0	1.4
Illnesses of siblings	0.9	1.3	3.2	-1.6	0.2	-0.7	-1.1	-1.4	-1.8	-1.2	-0.3	-0.7	-1.5	0.9	-0.9
High blood pressure (siblings)	0.9	1.3	5.0	1.8	-0.7	-0.9	1.2	2.2	-0.2	0.6	0.4	0.8	1.2	-0.6	0.9
Angina (self-reported)	0.9	1.1	4.4	0.7	0.0	-0.1	-0.6	0.5	1.2	1.5	0.4	0.7	2.1	-2.0	0.2
Medication: Ibuprofen	0.9	1.1	7.5	0.1	-0.6	-0.2	-1.0	0.5	-0.7	-0.7	2.7	0.3	-1.3	0.8	0.7
Had major operations	0.9	1.1	4.8	2.2	-0.0	-0.2	-0.0	1.4	0.5	-0.2	0.6	0.5	1.5	0.8	1.4
Family relationship satisfaction	0.9	1.1	3.2	1.5	0.2	-0.6	1.5	0.8	0.3	0.5	-1.8	0.5	0.8	1.3	1.3
Medication: Aspirin	0.9	1.2	3.1	0.9	0.2	0.6	0.9	1.1	1.4	1.5	1.2	0.6	1.8	-0.9	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	9.1	-0.5	-1.2	-1.5	-3.0	0.2	-1.3	-2.1	0.1	-0.9	-0.8	0.7	-0.8
Verbal and Numeric Reasoning (VNR)	0.8	1.9	5.2	1.7	0.4	0.9	2.3	1.1	0.9	1.5	-1.9	1.1	1.1	0.8	1.6
Rheumatoid Arthritis	0.8	1.0	3.6	-0.3	-0.3	0.2	-0.8	1.6	0.8	1.4	-1.6	-0.5	1.9	0.4	0.2
Blood Red Count	0.8	7.8	23.2	-2.9	-3.1	-3.0	-3.4	0.5	-2.8	-1.8	-3.5	-4.8	0.7	-0.2	-2.8
Systolic Blood Pressure	0.8	4.2	16.2	2.6	1.7	2.0	4.0	-0.0	1.5	2.7	0.0	2.7	0.9	0.3	1.6
Cardiovascular Disease	0.8	2.8	7.7	1.9	1.1	0.6	1.1	1.6	1.4	2.2	-1.5	0.9	2.8	-2.6	0.3
Relative age of first facial hair	0.8	1.6	7.4	0.8	-0.7	-0.7	-0.0	2.7	0.5	0.9	-1.1	-0.1	2.3	-1.4	0.3
Had other major operations	0.8	1.0	2.5	-1.5	-1.1	-0.1	0.1	-0.4	-1.1	0.1	-0.7	-1.2	-0.6	-1.6	-1.6
Glaucoma (self-reported)	0.8	1.0	4.5	1.1	-1.1	-1.3	-0.0	1.6	-0.8	-0.0	-2.1	-0.0	0.2	-0.3	-0.4
Worry too long after embarrassment	0.8	1.3	5.5	0.5	0.3	-0.4	0.9	-2.3	0.0	-0.3	-1.7	0.2	-1.0	2.1	-0.1
Emphysema/chronic bronchitis	0.8	0.9	6.4	0.3	-0.3	0.5	0.6	-1.0	-0.3	-0.2	0.4	0.2	-0.1	2.5	1.5
Knee pain experienced in last month	0.8	1.2	7.8	1.0	0.2	0.7	0.1	-1.2	-0.1	0.6	-0.3	0.8	-1.5	2.8	0.9
Commuting to job workplace: Walk	0.8	0.9	1.8	-0.4	-1.1	-1.2	-1.3	1.1	-0.0	-0.8	-0.9	-1.2	1.1	-0.8	-0.2
Medication: Gliclazide	0.8	0.9	2.3	-0.9	1.5	1.2	1.5	0.4	1.1	0.7	-1.3	-0.3	0.6	-0.2	0.4
Basal cell carcinoma (self-reported)	0.8	1.0	2.8	-1.7	-1.0	-0.6	-0.7	-0.1	-1.3	-0.8	-0.1	-1.3	-0.8	-0.9	-1.2
Hypothyroidism (self reported)	0.7	1.7	5.3	-1.6	-1.4	-1.1	-0.8	0.5	-0.2	0.0	-1.3	-1.2	1.7	-2.3	-1.6
Sensitivity / hurt feelings	0.7	1.1	2.7	0.9	1.4	0.9	1.6	-1.4	1.5	-0.2	-0.3	1.0	-0.5	1.1	0.7
Medication: Levothyroxine sodium	0.7	1.2	4.7	-1.0	-1.4	-1.1	-1.4	0.6	0.4	0.2	-0.9	-0.7	2.2	-1.3	-0.7
Pulse rate	0.7	1.1	7.0	-1.2	1.1	0.4	-0.1	-2.7	0.5	-0.7	0.6	-0.8	-1.1	1.0	-0.1
Medication: Cholesterol lowering	0.7	1.0	5.7	-0.1	-0.2	-0.0	0.2	-0.0	0.7	0.4	-1.4	-0.6	1.8	-2.4	-0.8
Medication: Lansoprazole	0.7	0.8	5.0	-1.0	0.4	-0.1	-0.4	-0.3	0.4	0.4	1.2	-0.1	0.3	-2.2	-1.1
Impedance of arm (left)	0.7	3.2	15.1	-1.4	-1.1	-1.1	-1.3	-2.1	-1.7	-3.9	0.4	-0.9	-2.1	-1.4	-1.6
Length of working week for main job	0.7	0.8	3.3	0.5	-1.5	-0.9	-1.8	0.6	-0.7	-0.3	-0.1	-0.4	0.3	1.4	0.4
Gout (self-reported)	0.7	1.0	3.3	1.4	-0.6	-1.3	-0.8	0.6	-0.5	-0.0	-1.1	-0.2	0.5	1.8	1.4
Long-standing illness, disability or infirmity	0.7	1.1	2.8	-1.7	1.2	1.5	0.8	-1.5	0.7	0.5	0.3	-0.6	-0.9	1.5	0.1
Osteoporosis (self-reported)	0.7	0.9	3.7	-0.7	-0.5	-0.9	0.1	-0.3	-0.8	-0.1	-1.9	-1.5	1.5	-0.0	0.0
Unable to work because of sickness or disability	0.7	0.9	3.3	-1.8	-0.2	-0.3	-0.7	-0.9	-0.3	-0.7	0.0	-1.1	-1.5	-0.6	-1.6
Lupus	0.6	0.9	2.9	0.1	0.2	0.8	0.4	1.2	1.7	1.4	0.3	1.0	1.0	-1.0	0.6
Respiratory disease	0.6	1.3	4.4	-0.0	-1.1	-0.7	-1.3	-0.3	-0.5	-2.1	1.1	-0.4	-2.0	1.5	0.1
Lung FEV1/FVC ratio	0.6	3.2	11.8	0.5	1.8	1.4	2.8	-3.4	-0.1	0.7	2.0	2.0	-2.1	0.2	0.3
Townsend deprivation index at recruitment	0.6	0.9	2.6	0.5	-1.1	-1.4	-0.5	1.6	-0.3	-1.1	-0.7	-0.5	0.5	-1.2	0.0
Chronic bronchitis/emphysema (father)	0.6	0.7	2.4	-0.1	-0.7	-0.4	-0.0	1.5	0.5	0.5	-1.4	-0.3	1.3	0.4	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.6	-1.7	0.2	0.0	1.4	-0.5	-0.9	-0.2	-1.2	-0.3	-1.1	-1.9	-1.8
Impedance of arm (right)	0.6	3.0	15.8	-1.1	-1.8	-1.4	-1.1	-1.2	-1.9	-4.0	0.4	-1.0	-1.5	-1.1	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.8	0.2	-0.4	-0.9	0.9	-1.4	-0.8	-0.8	-1.9	-0.4	-1.3	0.1	-0.5
Birth weight of first child	0.6	1.1	6.2	0.1	-1.0	-0.6	-1.3	0.9	0.0	-0.6	-2.5	-0.6	0.6	-1.3	-0.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	4.1	-1.3	-1.3	-0.8	-0.4	0.5	0.2	0.4	-1.5	-1.1	2.0	-1.5	-0.9
Number of children fathered	0.6	0.7	2.3	-1.1	-0.2	0.5	-0.1	-0.7	-0.7	0.7	1.5	0.1	-1.4	-0.5	-0.8
Medication: Omeprazole	0.6	0.7	2.3	-0.2	-0.9	-1.1	-0.5	-0.0	-0.2	-1.5	-1.2	-1.1	-0.6	0.3	-0.5
Number of full sisters	0.6	0.8	2.1	-1.3	-0.0	0.6	-0.3	-0.7	0.2	-0.7	0.9	-1.3	-1.4	1.5	-0.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.1	0.3	0.2	0.8	1.4	0.8	0.9	0.4	-1.2	0.8	1.4	0.0	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.8	-0.2	0.8	-0.1	0.2	-1.0	-0.1	-1.0	1.4	-0.4	-1.2	-1.0	-1.2
Qualifications: nursing, teaching	0.6	1.0	3.5	1.2	0.5	0.7	-0.4	1.9	0.9	0.6	-0.1	1.2	1.3	-0.5	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	3.3	-0.2	0.3	1.0	1.8	0.1	0.8	0.9	1.3	0.1	-0.3	-0.0	-0.0
Osteoarthritis (self-reported)	0.6	0.8	2.4	-0.2	-1.6	-1.1	-1.0	0.6	-0.7	-0.9	-1.4	-0.8	-0.5	0.7	-0.2
Mother’s age at death	0.6	0.8	1.9	0.4	0.6	0.7	0.3	1.2	1.2	0.9	0.8	0.8	1.1	0.2	1.4
Financial situation satisfaction	0.6	0.8	2.3	1.0	-0.8	-1.1	1.1	1.5	-0.3	-0.8	-1.3	-0.1	0.2	0.2	0.1
Supplements: Fish oil (including cod liver oil)	0.6	0.7	3.0	0.5	-1.6	-0.6	0.6	1.7	-0.5	-0.2	1.2	-0.2	0.3	-0.6	-0.4
Cholesterol lowering medication	0.6	0.9	3.5	-1.1	-0.1	-1.0	-0.2	-0.4	-1.1	-0.5	-1.9	-1.0	-0.6	-0.8	-1.0
Alcohol drinker status: Previous	0.6	0.7	2.9	-0.9	-1.1	-0.7	-1.0	-0.2	-0.5	-0.8	-0.0	-1.7	-0.6	0.1	-0.8
Depressed Affect (Nagel 2018)	0.5	1.1	3.8	-0.5	1.3	0.4	1.2	-1.9	-0.2	0.3	-1.0	0.4	-0.9	1.9	-0.0
Breast Cancer	0.5	1.3	3.6	0.9	1.5	1.9	-0.0	-0.2	1.4	1.3	1.1	1.9	0.1	0.2	0.7
Mean Putamen Volume	0.5	0.5	1.6	-0.4	-0.6	-0.2	1.0	1.3	-0.8	1.1	-0.5	-0.1	-0.3	-0.9	-0.4
Blood Eosinophil Count	0.5	3.6	8.1	-1.5	-2.8	-2.3	-0.9	-0.3	-2.2	-2.5	-2.0	-2.2	-2.0	1.3	-1.3
Number of treatments/medications taken	0.5	0.9	2.8	-0.6	1.4	1.0	0.6	-0.6	1.7	0.3	0.9	-0.1	0.6	-1.6	-0.5
Ever had hysterectomy (womb removed)	0.5	0.5	1.2	-0.9	-0.1	-0.1	0.7	-1.1	-0.9	-0.1	-0.8	-0.8	-0.8	-0.2	-1.0
High blood pressure (mother)	0.5	0.7	2.3	1.0	-1.4	-1.5	0.4	0.6	-0.9	-0.6	1.0	0.6	-0.1	-0.9	-0.1
Hair/balding pattern: Pattern 2	0.5	0.7	3.5	-0.3	-0.0	0.1	-1.1	0.6	-0.1	-0.2	1.9	0.0	-1.5	-0.6	-0.8
Financial difficulties in last 2 years	0.5	0.7	4.8	-0.1	-0.4	-0.7	-0.5	0.6	-0.6	0.4	-1.0	0.1	-0.4	-2.2	-0.8
Happiness	0.5	0.6	1.9	-0.0	-0.7	-1.4	1.2	0.1	-0.6	-0.3	-1.4	-0.9	0.3	0.9	-0.1
Lung cancer (father)	0.5	0.6	2.4	-1.6	-0.4	0.8	-1.0	0.1	1.3	-0.4	0.4	-0.7	-0.5	0.1	-0.3
Exposure to tobacco smoke outside home	0.5	0.7	1.7	0.1	-1.2	-0.9	-1.2	1.3	-0.9	-0.9	0.3	-0.5	-0.5	0.6	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	4.3	0.5	1.0	0.5	-0.2	-0.2	0.0	0.1	0.8	0.2	-0.8	2.1	0.4
Health satisfaction	0.5	0.6	3.2	-0.1	-0.4	-1.4	0.6	0.2	-0.7	-0.7	-1.8	-0.8	-0.4	0.5	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.6	0.7	0.4	0.2	0.6	1.2	0.5	1.3	1.2	0.8	0.8	-1.6	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.7	-0.8	-1.1	-1.3	-1.2	0.2	-1.2	-0.5	-1.2	-0.2	0.9	-1.2	-1.2
Average weekly champagne plus white wine intake	0.5	0.6	3.0	-0.5	0.7	-0.5	0.0	-0.5	-1.1	0.2	-1.0	-1.0	-0.3	1.7	-0.1
Wears glasses or contact lenses	0.5	0.6	2.0	1.0	-1.2	-1.4	1.3	0.8	-0.7	0.2	-0.1	0.2	0.2	0.2	0.1
Illnesses of father: High blood pressure	0.5	0.6	3.3	0.5	-0.4	-0.8	-0.1	0.6	-1.0	0.6	-0.1	-0.1	-1.0	1.8	0.4
Risk taking	0.5	0.7	3.7	-0.2	-0.1	0.1	-1.1	0.3	-0.5	-0.9	1.3	-0.1	-1.9	0.7	-0.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.9	-0.3	0.4	-0.3	-0.2	0.2	-1.4	-1.3	-0.6	-0.6	-1.1	1.0	-0.2
Diastolic blood pressure, automated reading	0.5	1.6	4.3	0.9	1.2	1.1	1.4	0.6	1.5	1.7	-0.6	1.2	2.1	-1.4	0.3
Myopia	0.5	0.7	4.2	2.0	-0.5	-0.7	0.1	1.1	0.1	0.3	1.1	0.1	0.6	0.7	0.5
Chronotype (morning person)	0.4	0.9	4.0	0.8	0.9	0.8	0.4	-1.0	0.5	-0.3	2.0	1.1	-1.4	-0.0	0.4
Vitamin and mineral supplements	0.4	0.5	3.3	-0.7	-0.2	-0.1	-0.4	-1.2	-0.0	-0.3	-1.8	-0.5	0.3	-0.3	-0.3
Pack years adult smoking proportion	0.4	0.7	3.5	-1.9	-0.4	-0.3	-1.4	0.2	0.4	-0.1	0.2	-1.1	0.5	0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.1	-1.3	-0.0	0.0	1.0	-0.7	-0.6	0.0	-0.8	-0.2	-1.2	-1.3	-1.4
Qualifications: CSEs or equivalent	0.4	0.6	2.3	-0.2	-0.4	-0.4	0.2	-0.7	-0.7	-0.9	0.2	-0.1	-1.0	-1.5	-1.0
Pain all over the body in last month	0.4	0.4	3.5	-0.7	-0.0	-0.0	0.7	0.0	0.7	0.4	1.9	0.3	-0.2	0.1	0.0
Medication: Simvastatin	0.4	0.6	2.0	-0.7	0.7	0.3	0.9	-1.0	0.2	-0.5	-1.4	-0.9	0.2	-0.7	-0.5
Father’s age at death	0.4	0.5	1.9	-0.8	0.1	-0.0	-0.1	-1.0	-0.3	-0.8	0.3	-1.1	-0.4	1.4	0.5
Depression (self-reported)	0.4	0.5	1.4	0.4	1.2	0.7	0.8	-0.0	0.2	1.1	-0.8	0.8	0.3	-0.1	0.7
Illnesses of mother	0.4	0.5	2.0	-0.4	1.3	1.0	0.0	-1.4	0.3	-0.2	-0.0	0.3	-0.5	0.7	-0.2
Standing height	0.4	3.7	9.5	-1.6	-2.6	-1.5	-2.9	0.3	-1.3	-3.1	1.8	-2.2	-1.3	-0.6	-1.6
Medication: Amlodipine	0.4	0.5	1.4	0.3	0.4	0.4	0.9	1.2	1.1	0.7	-0.2	0.3	0.8	-0.9	-0.1
Birth weight	0.4	0.9	3.2	1.5	-0.4	-0.9	1.1	1.1	-0.1	0.2	-1.8	0.8	0.9	0.6	0.7
Eye problems/disorders: None of the above	0.4	0.5	2.3	-0.3	-1.5	-1.1	-0.3	0.2	-1.0	-0.1	0.1	-0.6	-0.5	-0.1	-0.8
Medication for pain relief, constipation, heartburn	0.4	0.8	5.8	0.5	-0.0	0.3	-0.2	-0.4	0.3	0.1	-2.4	-0.0	1.1	1.2	0.2
Pulse rate, automated reading	0.4	1.2	4.8	-1.2	0.6	0.9	0.8	-2.2	1.0	-1.4	-0.1	-1.1	-1.3	0.2	-0.4
Chest pain or discomfort	0.4	0.5	1.9	1.2	-0.1	-0.0	-1.1	0.3	0.1	-0.1	1.4	0.1	0.3	0.6	1.1
Ever had bowel cancer screening	0.4	0.5	1.5	0.2	0.6	0.8	0.6	-0.1	0.9	1.2	1.0	0.7	-0.1	-0.4	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	2.5	-0.3	-0.7	0.0	-0.6	-0.3	-0.5	-0.8	-0.7	-0.7	0.1	1.6	0.6
Medication for cholesterol	0.4	0.6	2.6	0.9	-1.6	-0.3	-0.6	1.1	-0.1	-0.6	0.2	0.4	0.5	0.9	1.0
Miserableness	0.4	0.7	4.9	0.5	0.7	-0.1	0.3	-0.9	-0.3	-0.6	-2.2	-0.2	-0.1	1.1	0.3
Eye problems/disorders: Glaucoma	0.4	0.5	1.8	0.6	-0.7	-0.8	0.6	1.1	-0.8	-0.2	-1.3	-0.1	-0.4	0.1	-0.3
Medication: Lisinopril	0.4	0.5	1.3	-0.4	1.0	0.8	0.6	-0.5	1.1	0.8	-1.1	0.6	-0.3	0.4	-0.1
Medication: Atorvastatin	0.4	0.5	1.3	1.0	-0.8	-0.3	0.3	-0.1	0.2	1.0	-1.1	0.6	1.1	-0.3	0.6
Number of operations (self-reported)	0.4	0.6	2.0	-0.4	-1.1	-0.5	-0.7	1.3	-0.1	0.8	-0.6	-0.7	1.4	-0.6	0.2
Heart disease (siblings)	0.4	0.4	1.8	0.2	0.3	1.1	0.5	-0.6	1.4	0.7	0.5	0.1	-0.4	0.9	0.1
Pack years of smoking	0.4	0.6	3.7	-1.9	-0.4	-0.0	-1.0	0.5	0.6	0.4	0.2	-1.0	0.6	0.2	-0.4
Ovarian Cancer	0.3	0.4	1.4	-0.1	0.5	0.1	1.0	-0.2	-0.8	-0.4	0.8	-0.1	-1.2	-0.5	-0.8
Coronary Artery Disease (CAD)	0.3	0.4	1.8	-0.6	-0.2	0.0	0.7	-1.4	-0.3	0.1	0.5	0.2	-1.1	0.4	-0.2
HbA1C	0.3	0.4	1.2	0.3	-0.1	-0.8	-0.6	-1.1	-0.5	-0.3	-0.9	-0.5	-0.3	0.8	-0.1
Neuroticism (2016)	0.3	0.4	2.1	0.8	0.7	-0.1	-0.5	-1.5	0.4	-0.3	-0.3	-0.5	-0.8	0.6	-0.4
Blood White Count	0.3	2.1	8.9	-3.0	0.5	0.7	-0.8	-2.3	0.1	-1.1	-0.1	-2.4	-1.1	-0.3	-1.5
Heel T-Score	0.3	2.6	9.9	-1.9	1.3	0.1	1.5	-3.1	-1.1	0.3	0.1	0.5	-2.9	1.4	-1.5
Waist Hip Ratio (WHR)	0.3	1.6	11.6	-0.9	-0.5	-0.7	-0.4	-0.7	-1.0	-0.3	-3.4	-1.8	-0.1	0.6	-0.6
Taking other prescription medications	0.3	0.4	1.2	-1.1	0.5	0.2	-0.1	-0.8	1.0	-0.4	0.6	-0.4	0.2	-1.0	-0.5
Qualifications: None of the above	0.3	0.7	4.6	-1.2	-0.1	-0.2	-0.7	-0.3	0.1	-1.0	2.1	-0.8	0.1	-0.3	-0.2
Medication: Ramipril	0.3	0.4	1.3	0.7	0.3	0.4	-0.1	-0.1	0.2	1.0	0.8	0.3	0.9	-1.1	0.4
Hip circumference	0.3	1.4	3.0	-1.3	-1.4	-1.3	-0.8	-0.7	-1.2	-1.7	-0.8	-1.4	-1.4	0.0	-1.0
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.2	-0.6	-0.9	-0.2	-0.5	-0.3	-0.8	-1.1	-0.2	-0.3	-1.1	0.4	0.1
Pulse wave peak to peak time	0.3	0.4	1.3	-0.1	0.5	-0.7	-0.0	-0.0	-1.1	-0.8	0.5	-1.1	-0.4	0.5	-0.1
Shortness of breath walking on level ground	0.3	0.3	0.7	0.8	0.1	-0.1	0.4	0.7	0.7	0.1	0.8	0.8	0.6	-0.2	0.7
Neck or shoulder pain in last month	0.3	0.4	2.3	-0.2	0.7	0.6	0.2	-0.2	-0.0	-0.2	1.0	0.2	-1.5	-0.6	-0.6
Medication: Allopurinol	0.3	0.4	1.8	0.8	-0.1	-1.1	-0.1	0.3	-0.2	0.1	-1.4	-0.0	0.0	1.0	0.3
Medication: Seretide 50 evohaler	0.3	0.4	1.9	-0.5	-0.4	0.7	-0.1	-0.0	1.0	0.1	-0.5	-0.6	-0.5	1.4	0.5
Alcohol intake frequency.	0.3	0.7	2.1	-0.8	-0.6	-1.1	-0.5	-0.4	-1.3	-0.8	0.8	-0.8	-1.5	-0.3	-0.6
Leg pain on walking	0.3	0.4	1.8	0.6	-0.3	-0.8	-0.8	1.3	-0.7	-0.3	0.4	-0.1	0.6	0.0	0.5
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.7	0.3	0.3	-0.4	-0.1	-0.1	-0.6	-1.1	1.3	0.4	0.2	0.0	0.5
Leg fat percentage (left)	0.3	1.0	2.9	-1.7	-0.2	0.0	0.4	-1.4	-0.5	-0.0	-1.5	-1.4	-1.0	-0.4	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.2	-1.0	-0.6	-0.8	-0.6	-0.1	0.3	-0.8	-0.2	-1.1	-0.2	-0.3	-0.6
Ulcerative Colitis (UC)	0.2	0.4	1.0	-0.8	0.6	0.7	-1.0	0.4	0.3	0.2	0.6	-0.6	0.1	1.0	0.6
Bipolar Disorder (2011)	0.2	0.1	0.4	-0.6	0.2	0.6	-0.4	-0.1	0.6	0.3	0.2	-0.5	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.7	-0.2	-0.8	-0.5	-0.4	-0.2	-0.8	-0.7	0.2	-0.2	-0.4	0.0	-0.2
Ulcerative Colitis	0.2	0.4	1.7	-0.9	0.7	0.0	0.2	0.1	0.2	-0.1	0.7	-0.8	-0.3	1.3	0.1
BMI	0.2	1.1	2.5	1.3	0.8	0.6	1.0	1.2	0.9	1.6	0.4	0.6	0.9	1.2	1.4
Height	0.2	3.8	19.8	-1.9	-1.5	0.2	-3.3	1.8	0.3	-1.6	4.5	-1.1	-0.5	-1.2	-0.5
Tanning	0.2	2.6	5.8	-1.8	-1.3	-0.5	-1.8	-0.4	-1.4	-2.3	1.4	-0.9	-2.4	-1.3	-2.2
Leg fat-free mass (left)	0.2	1.1	2.9	1.0	0.2	0.9	0.3	1.1	1.4	0.7	1.7	0.8	0.2	1.5	1.5
Fed-up feelings	0.2	0.4	1.8	-0.1	0.5	0.2	1.4	-0.6	0.5	0.4	-1.1	0.1	0.6	-0.4	-0.3
Supplements: Glucosamine	0.2	0.3	1.8	-0.2	0.1	0.4	-0.1	0.3	0.3	0.3	0.9	0.4	-0.2	1.4	0.4
Sitting height	0.2	1.2	3.2	-0.6	-1.6	-0.6	-1.8	1.2	-0.4	-0.9	1.0	-0.9	0.1	-1.6	-0.8
Body mass index (BMI)	0.2	0.7	2.0	-0.0	1.0	1.0	1.4	-0.5	1.0	1.2	-0.1	0.3	-0.4	1.1	0.6
Leg predicted mass (left)	0.2	1.1	3.0	0.9	0.2	0.9	0.3	1.1	1.4	0.7	1.7	0.8	0.2	1.4	1.5
Time employed in main current job	0.2	0.3	1.0	-1.0	0.3	0.1	-0.6	-0.9	0.2	0.4	-0.2	-0.2	0.2	-0.5	-0.7
Alcohol intake versus 10 years previously	0.2	0.4	1.3	0.3	-0.2	-0.3	-0.5	-0.8	-0.5	-0.8	1.1	0.1	-0.8	-0.6	-0.2
Pulse wave Arterial Stiffness index	0.2	0.3	0.8	-0.1	-0.7	0.6	-0.2	-0.1	0.9	0.4	-0.4	0.8	0.2	-0.6	-0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.7	-0.5	-0.0	0.2	0.5	1.3	-0.1	-0.7	-0.5	0.6	0.2	-0.0	0.3
Leg fat percentage (right)	0.2	0.6	1.5	-1.2	0.5	0.8	1.1	-1.2	0.2	0.4	-1.0	-0.9	-0.6	-0.1	-0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	-0.3	0.1	0.8	-0.8	0.4	0.7	0.2	-0.0	0.2	0.6	-0.1	-0.2
Supplements: Vitamin C	0.2	0.2	1.2	0.1	0.6	0.4	0.5	0.4	-0.2	0.6	1.1	0.1	-0.3	-0.4	0.1
Arm fat percentage (left)	0.2	0.6	3.0	-0.5	0.7	0.8	1.3	-1.7	0.4	-0.1	-0.2	-0.1	-1.0	0.6	0.2
Number of self-reported non-cancer illnesses	0.2	0.4	2.8	-0.6	0.4	0.1	0.4	0.5	0.1	0.3	-0.2	-0.4	-0.3	-1.7	-0.8
Medication: Blood pressure	0.2	0.5	1.9	-0.3	0.8	0.2	0.1	0.5	0.8	0.9	0.5	0.4	0.6	-1.4	-0.6
Hair Pigment	0.1	4.1	9.8	-2.9	-1.5	-2.3	-1.4	-1.8	-2.0	-2.1	-2.1	-3.1	-0.2	-0.7	-2.2
Trunk fat percentage	0.1	0.5	1.6	-1.3	-0.4	0.2	0.3	-1.1	-0.0	-1.1	0.6	-0.7	-1.0	-0.3	-0.5
Trunk fat mass	0.1	0.4	1.1	-1.0	-0.5	0.2	0.3	-0.7	0.1	-0.7	0.6	-0.9	-0.8	0.2	-0.2
Waist circumference	0.1	0.4	1.1	-1.0	-0.2	0.0	0.6	-0.4	0.0	-0.0	-1.1	-1.0	-0.6	0.8	-0.0
Weight	0.1	0.3	0.7	-0.8	-0.2	0.4	0.1	-0.4	0.5	-0.1	0.6	-0.8	-0.8	0.7	-0.2
Arm fat percentage (right)	0.1	0.4	1.7	-0.4	0.4	0.6	1.3	-1.2	0.2	-0.1	-0.2	-0.1	-0.7	0.5	0.2
Trunk fat-free mass	0.1	0.4	1.1	0.3	-0.5	0.2	-0.4	1.0	0.8	0.6	1.0	-0.2	0.4	0.9	0.5
Trunk predicted mass	0.1	0.4	1.1	0.2	-0.4	0.2	-0.4	0.8	0.7	0.6	1.0	-0.2	0.3	0.9	0.5
Body fat percentage	0.1	0.5	1.7	-1.3	-0.1	0.4	0.6	-1.2	0.0	-0.5	-0.0	-0.8	-0.8	-0.4	-0.5
Arm fat-free mass (right)	0.1	0.4	1.0	-0.1	-0.2	0.4	-0.7	0.8	0.9	1.0	1.0	-0.4	0.5	0.5	0.3
Whole body fat mass	0.1	0.2	0.8	-0.9	-0.1	0.3	0.7	-0.4	0.3	-0.2	0.4	-0.7	-0.6	0.1	-0.1
Leg fat mass (right)	0.1	0.2	0.6	-0.7	0.1	0.7	0.8	-0.2	0.6	0.5	-0.0	-0.5	-0.4	0.5	0.2
Arm predicted mass (right)	0.1	0.4	1.0	-0.1	-0.4	0.3	-0.8	1.0	0.7	0.9	0.8	-0.5	0.4	0.5	0.3
Whole body fat-free mass	0.1	0.6	1.5	0.4	-0.3	0.4	-0.2	1.1	1.0	0.7	1.2	0.1	0.4	1.1	0.8
Leg fat-free mass (right)	0.1	0.6	1.9	0.5	-0.2	0.4	-0.1	1.0	0.9	0.3	1.4	0.4	-0.1	1.4	1.1
Whole body water mass	0.1	0.5	1.3	0.3	-0.4	0.4	-0.3	1.0	0.9	0.6	1.2	0.0	0.3	1.0	0.7
Leg predicted mass (right)	0.1	0.7	2.2	0.6	-0.1	0.5	-0.2	1.0	0.9	0.3	1.5	0.4	-0.1	1.5	1.2
Arm fat mass (left)	0.1	0.4	1.4	-0.6	0.3	0.5	0.9	-1.2	0.2	-0.1	-0.1	-0.4	-1.0	0.6	0.0
Basal metabolic rate	0.1	0.3	1.1	-0.1	-0.4	0.3	-0.3	0.7	0.6	0.3	1.0	-0.3	-0.1	0.9	0.4
Arm fat-free mass (left)	0.1	0.3	0.8	-0.5	-0.9	0.1	-0.7	0.8	0.4	0.8	0.5	-0.8	0.3	0.2	-0.1
Average weekly beer plus cider intake	0.1	0.2	0.8	-0.2	-0.1	0.9	0.5	-0.2	0.9	-0.5	-0.0	0.1	-0.6	0.1	0.1
Leg fat mass (left)	0.1	0.3	1.1	-1.0	-0.3	0.2	0.4	-0.4	0.0	0.3	-0.3	-0.9	-0.7	0.3	-0.2
Arm fat mass (right)	0.0	0.2	0.5	-0.5	0.0	0.4	0.7	-0.5	0.2	0.0	0.2	-0.4	-0.6	0.5	0.1
Arm predicted mass (left)	0.0	0.2	0.5	-0.4	-0.6	0.1	-0.6	0.7	0.4	0.6	0.5	-0.7	0.0	0.4	-0.1

Hub : Genes

HAX1

Models

Trait associations