[Hub]/) : Traits : Type 2 Diabetes (T2D) (2018) :

chr3:49,030,828-50,800,146

Best TWAS P=9.37e-10 · Best GWAS P=2.44e-09 conditioned to 0.0414

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RNF123 0.14 0.10 blup 324 0.12 4.7e-14 5.0 5.5 2.9e-08 -0.64 0.42 0.57 FALSE
2 GTEx Artery Aorta UBA7 0.06 0.02 enet 12 0.01 5.3e-02 4.9 -5.8 7.9e-09 0.65 0.12 0.72 FALSE
3 GTEx Brain Cerebellar Hemisphere FAM212A 0.25 0.17 lasso 21 0.20 8.1e-06 -5.0 5.4 5.6e-08 -0.57 0.22 0.55 FALSE
4 GTEx Brain Cortex RBM6 0.21 0.25 lasso 4 0.29 8.8e-09 -5.0 -5.9 4.2e-09 0.68 0.18 0.81 FALSE
5 GTEx Brain Cortex RNF123 0.23 0.05 enet 33 0.04 2.4e-02 4.7 5.5 4.5e-08 -0.71 0.04 0.84 FALSE
6 GTEx Brain Nucleus accumbens basal ganglia RBM6 0.20 0.19 enet 29 0.22 2.0e-06 -5.0 -6.1 9.4e-10 0.76 0.05 0.94 TRUE
7 GTEx Cells Transformed fibroblasts RBM6 0.27 0.29 enet 17 0.31 1.3e-23 -5.0 -5.2 2.2e-07 0.45 0.23 0.76 FALSE
8 GTEx Colon Transverse RBM6 0.29 0.33 enet 43 0.36 4.6e-18 -5.0 -5.1 2.7e-07 0.45 0.25 0.75 FALSE
9 GTEx Esophagus Gastroesophageal Junction RBM6 0.25 0.29 lasso 23 0.30 2.2e-11 -5.1 -5.2 2.3e-07 0.60 0.27 0.73 FALSE
10 GTEx Esophagus Mucosa RNF123 0.07 0.03 enet 9 0.04 1.8e-03 4.8 5.2 2.0e-07 -0.63 0.24 0.61 FALSE
11 GTEx Thyroid MST1R 0.06 0.06 enet 9 0.05 1.7e-04 4.9 5.7 1.0e-08 -0.71 0.19 0.79 FALSE
12 GTEx Vagina RBM6 0.24 0.22 enet 27 0.21 1.5e-05 -5.1 -5.1 3.1e-07 0.49 0.25 0.69 FALSE
13 METSIM Adipose RNF123 0.03 0.02 lasso 12 0.02 2.0e-04 4.7 5.5 4.6e-08 -0.80 0.10 0.89 FALSE
14 The Cancer Genome Atlas Breast Invasive Carcinoma RBM6 0.03 0.04 blup 79 0.05 9.5e-10 -5.0 -5.1 2.9e-07 0.46 0.06 0.94 FALSE
15 The Cancer Genome Atlas Breast Invasive Carcinoma UBA7 0.01 0.01 enet 5 0.01 6.6e-04 4.7 -5.6 2.3e-08 0.83 0.02 0.96 FALSE
16 The Cancer Genome Atlas Colon Adenocarcinoma UBA7 0.11 0.06 enet 5 0.05 7.6e-04 4.7 -5.9 3.0e-09 0.83 0.02 0.98 FALSE
17 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RBM6 0.09 0.11 blup 79 0.11 3.8e-12 -4.9 -5.2 2.7e-07 0.52 0.06 0.94 FALSE
18 The Cancer Genome Atlas Brain Lower Grade Glioma MST1R 0.08 0.07 enet 10 0.09 2.6e-10 4.9 5.3 1.2e-07 -0.54 0.02 0.98 FALSE
19 The Cancer Genome Atlas Brain Lower Grade Glioma TRAIP 0.02 0.01 enet 8 0.01 3.1e-02 4.0 5.1 2.9e-07 -0.58 0.04 0.12 FALSE
20 The Cancer Genome Atlas Lung Squamous Cell Carcinoma UBA7 0.02 0.01 blup 30 0.02 5.3e-03 4.8 -5.3 9.0e-08 0.67 0.06 0.35 FALSE
21 The Cancer Genome Atlas Pancreatic Adenocarcinoma CAMKV 0.07 0.05 enet 9 0.06 2.3e-03 4.8 5.2 1.5e-07 -0.59 0.03 0.29 FALSE
22 The Cancer Genome Atlas Testicular Germ Cell Tumors RBM6 0.16 0.12 blup 79 0.09 4.4e-04 -5.0 -5.8 8.6e-09 0.52 0.05 0.93 FALSE