TWAS hub - TRAIP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1410	0.0640	0.0016	0.084	NA	0.081	NA	0.077	0.00014	NA	0.00019	NA	0.00027
2	TCGA	Brain Lower Grade Glioma	0.0196	0.0137	0.0061	0.006	0.005	0.009	NA	0.004	0.05700	0.079	0.03100	NA	0.09800

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Pulse rate, automated reading	28.5	91.9	123.2	11.1	7.8
Qualifications: College or University degree	20.3	64.0	127.7	-0.5	-11.3
Qualifications: A levels/AS levels or equivalent	19.2	42.5	79.4	-2.4	-8.9
Crohns Disease (2017)	16.1	35.4	59.0	-3.4	-7.7
Crohns Disease (2012)	15.8	25.4	42.0	-3.0	-6.5
Heel bone mineral density (BMD) T-score, automated (right)	15.8	36.3	46.6	6.8	5.1
Alcohol intake versus 10 years previously	15.6	23.3	36.7	3.1	6.1
Intelligence (Savage-Jansen 2018)	15.0	45.9	86.5	-2.3	-9.3
Heel bone mineral density (BMD) T-score, automated (left)	14.9	33.9	39.7	6.3	5.3
Irritable Bowel Disease (IBD)	14.8	35.4	69.1	-1.3	-8.3
Age at First Birth	13.9	20.2	39.9	-0.7	-6.3
Pulse rate	13.9	23.4	37.3	6.1	3.1
Leg fat mass (left)	13.2	51.7	92.2	3.4	9.6
Leg fat mass (right)	13.0	50.4	90.6	3.2	9.5
Ever had bowel cancer screening	13.0	15.2	21.4	-3.0	-4.6
Leg fat percentage (left)	12.6	45.7	79.0	3.5	8.9
Leg fat percentage (right)	12.4	45.0	79.7	3.2	8.9
Whole body fat mass	12.4	51.6	88.0	3.9	9.4
Fluid intelligence score	12.3	25.6	45.3	-2.4	-6.7
Arm fat mass (right)	11.7	48.1	85.9	3.2	9.3
Body fat percentage	11.7	46.3	73.5	4.4	8.6
Arm fat mass (left)	11.5	47.3	83.9	3.3	9.2
Heel T-Score	11.3	89.6	123.2	11.1	7.5
Qualifications: nursing, teaching	11.3	17.6	30.8	-2.1	-5.5
Trunk fat mass	11.2	48.2	76.4	4.5	8.7
Type 2 Diabetes (T2D) (2018)	11.1	20.8	26.3	3.9	5.1
Verbal and Numeric Reasoning (VNR)	11.0	26.4	49.2	-1.9	-7.0
Trunk fat percentage	11.0	44.0	64.3	4.9	8.0
Body mass index (BMI)	10.7	45.5	87.4	1.9	9.3
Ulcerative Colitis	10.4	15.1	30.1	-0.1	-5.5
Arm fat percentage (left)	10.3	40.9	69.2	3.6	8.3
Waist circumference	10.2	37.3	60.5	3.8	7.8
Diabetes (self-reported)	10.1	15.6	18.7	3.5	4.3
Age at first live birth	10.1	17.9	35.7	-0.3	-6.0
Alcohol intake frequency.	10.0	23.3	34.6	3.5	5.9
Diastolic blood pressure, automated reading	10.0	30.9	42.6	4.4	6.5
Arm fat percentage (right)	9.9	39.0	67.7	3.2	8.2
Ulcerative Colitis (UC)	9.5	17.8	34.1	1.2	-5.8
Age at last live birth	9.5	13.8	27.5	0.3	-5.2
Taking other prescription medications	9.4	14.5	27.6	1.2	5.3
Leg pain on walking	9.4	11.8	21.7	1.3	4.7
Qualifications: None of the above	9.3	19.8	38.9	-0.8	6.2
Overall health rating	9.2	19.8	39.6	-0.1	6.3
Average weekly beer plus cider intake	9.1	13.2	26.2	0.4	5.1
Diabetes diagnosed by doctor	8.9	14.6	15.7	3.7	4.0
BMI	8.8	50.8	97.6	2.0	9.9
Weight	8.6	42.5	75.7	3.0	8.7
Supplements: Calcium	8.1	8.9	9.4	-2.9	-3.1
Blood Red Count	7.8	74.9	92.9	9.6	7.5
Medication: Ventolin 100micrograms inhaler	7.7	9.9	16.6	1.8	4.1
Number of treatments/medications taken	7.5	13.4	26.0	0.9	5.1
Mean time to correctly identify matches	7.4	14.1	16.2	-3.5	-4.0
Qualifications: NVQ or HND or HNC or equivalent	7.4	8.9	12.3	2.4	3.5
Frequency of tiredness / lethargy in last 2 weeks	6.6	10.8	21.4	-4.6	-0.4
Wheeze or whistling in the chest in last year	6.6	11.8	22.1	1.2	4.7
Reaction Time	6.5	12.3	13.4	-3.4	-3.7
Medication: Co-codamol	6.2	7.2	13.9	-0.8	3.7
Waist Hip Ratio (WHR)	6.0	26.9	42.9	6.5	3.3
Miserableness	5.9	10.3	17.5	-1.7	4.2
Fed-up feelings	5.8	10.5	20.2	-0.9	4.5
HDL Cholesterol	5.7	9.6	11.2	-2.8	-3.3
Relative age voice broke	5.7	8.7	14.6	-3.8	-1.7
Medication: Seretide 50 evohaler	5.7	6.5	12.8	0.5	3.6
Average weekly champagne plus white wine intake	5.7	7.8	12.2	-1.8	-3.5
Blood Eosinophil Count	5.6	43.3	46.2	6.4	6.8
Medication for cholesterol, blood pressure or diabetes	5.4	9.0	13.2	-2.2	-3.6
Ever depressed for a whole week	5.3	6.6	12.7	-3.6	0.7
Ever smoked	5.2	9.1	17.3	-4.2	-1.0
Osteoporosis (self-reported)	4.9	6.0	7.7	-2.8	-2.1
Arm predicted mass (left)	4.8	24.6	48.0	1.1	6.9
Medication: Metformin	4.7	6.6	6.7	2.6	2.5
Qualifications: CSEs or equivalent	4.7	6.2	12.3	0.4	3.5
Chronic bronchitis/emphysema (mother)	4.7	5.4	10.6	0.5	3.3
Arm fat-free mass (left)	4.7	23.8	46.5	1.1	6.8
Depression (self-reported)	4.6	5.5	9.5	-3.1	-1.2
Myopia	4.6	6.7	8.6	-2.9	-2.2
HbA1C	4.5	5.0	9.6	3.1	0.6
Pain experienced in last month	4.5	7.5	14.2	0.9	-3.8
Frequency of unenthusiasm / disinterest in last 2 weeks	4.4	5.9	11.1	0.8	3.3
Exposure to tobacco smoke at home	4.4	4.9	9.5	-0.5	3.1
Arm predicted mass (right)	4.4	22.3	43.6	1.0	6.6
Basal metabolic rate	4.4	24.5	46.8	1.5	6.8
Ever highly irritable/argumentative for 2 days	4.3	5.2	8.0	-1.5	2.8
Depressed Affect (Nagel 2018)	4.1	8.5	15.2	-1.4	3.9
Chronotype (morning person)	4.1	9.4	14.4	2.1	-3.8
Leg fat-free mass (left)	4.1	21.6	40.5	1.7	6.4
Age when periods started (menarche)	4.1	9.8	12.5	-3.5	2.7
Serious illness, injury or assault of a close relative in last 2 years	4.1	4.8	7.5	-2.7	-1.4
Impedance of arm (left)	4.1	18.9	27.8	3.2	-5.3
Smoking Status	4.0	9.6	17.4	-4.2	1.3
Leg predicted mass (left)	4.0	21.4	40.2	1.6	6.3
Arm fat-free mass (right)	4.0	20.5	39.8	1.1	6.3
Medication: Omeprazole	4.0	4.8	9.4	0.5	3.1
Osteoarthritis (self-reported)	4.0	5.2	10.2	0.4	3.2
Basal cell carcinoma (self-reported)	4.0	4.7	9.0	-0.6	-3.0
Number of operations (self-reported)	3.9	5.8	8.3	-2.9	1.8
Impedance of arm (right)	3.8	17.9	28.0	2.8	-5.3
Exposure to tobacco smoke outside home	3.8	5.0	9.8	-0.5	3.1
Number of full brothers	3.8	4.7	7.5	-2.7	1.4
Mood swings	3.8	6.9	13.8	0.1	3.7
Blood White Count	3.7	27.5	46.0	3.0	6.8
Past tobacco smoking	3.7	6.8	13.4	3.7	0.4
Ever unenthusiastic/disinterested for a whole week	3.7	4.6	6.1	-2.5	1.8
Hip circumference	3.7	15.9	31.7	0.2	5.6
Bipolar Disorder (2011)	3.6	3.5	6.1	-2.5	-0.9
Number of live births	3.6	5.1	9.9	0.6	3.2
Age started oral contraceptive pill	3.6	4.5	8.3	-0.8	-2.9
Diabetes (mother)	3.5	4.5	5.2	1.9	2.3
Mouth/teeth dental problems: Dentures	3.5	6.0	11.7	-0.5	3.4
Prospective memory result	3.5	4.4	6.6	1.5	2.6
Medication: Paracetamol	3.5	5.5	8.0	-2.8	1.7
Systolic Blood Pressure	3.4	17.2	20.7	3.7	4.5
Hearing difficulty/problems with background noise	3.4	5.4	6.1	-2.2	-2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.4	4.0	6.4	1.3	2.5
Prostate Cancer	3.3	4.7	9.3	-0.3	3.0
Bilateral oophorectomy (both ovaries removed)	3.2	3.7	7.2	0.5	2.7
Leg fat-free mass (right)	3.2	17.1	31.9	1.5	5.6
Impedance of whole body	3.2	16.4	18.4	3.8	-4.3
Coronary Artery Disease (CAD)	3.1	3.7	6.7	0.9	2.6
Medication: Paracetamol	3.1	5.1	7.1	-2.7	1.8
Chest pain or discomfort	3.1	4.4	8.1	-2.9	0.9
Had major operations	3.1	3.7	5.1	-2.2	1.5
Leg predicted mass (right)	3.1	16.7	31.1	1.5	5.6
Maternal smoking around birth	3.0	4.4	7.8	0.9	2.8
Knee pain experienced in last month	3.0	4.7	8.3	-1.1	2.9
Medication: Cholesterol lowering	2.9	4.5	6.1	1.7	2.5
Pulse wave reflection index	2.9	3.6	7.0	-2.6	-0.4
Number of children fathered	2.9	3.2	6.5	0.0	2.5
Whole body water mass	2.9	16.8	33.0	0.8	5.7
Guilty feelings	2.9	4.4	7.5	-1.2	2.7
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	5.3	0.8	2.3
Father’s age at death	2.8	3.8	7.4	-0.5	-2.7
Lung cancer (father)	2.8	3.3	6.2	0.7	2.5
Health satisfaction	2.8	3.7	6.8	0.8	2.6
Whole body fat-free mass	2.8	16.3	32.0	0.7	5.7
Friendships satisfaction	2.8	3.4	5.4	-1.2	-2.3
Schizophrenia vs Biploar Disorder	2.7	3.5	6.4	0.8	-2.5
Breast Cancer	2.7	6.6	12.2	-1.0	-3.5
Hand grip strength (right)	2.7	7.2	11.8	1.6	3.4
Pain all over the body in last month	2.7	2.9	3.7	-1.5	1.9
Medication: Blood pressure	2.7	4.8	8.1	1.2	2.8
Loneliness, isolation	2.7	3.8	7.0	-0.7	2.6
Financial situation satisfaction	2.7	3.3	6.5	0.4	2.6
Alzheimer’s Disease (in mother)	2.6	3.0	3.5	1.6	1.9
Relative age of first facial hair	2.6	5.4	10.6	-3.2	0.4
Other serious medical condition/disability diagnosed by doctor	2.6	3.4	3.7	-1.7	-1.9
Average weekly spirits intake	2.5	3.1	6.1	0.2	2.5
Eye problems/disorders: Diabetes related eye disease	2.5	2.7	4.6	2.1	0.9
Vitamin and mineral supplements	2.5	3.3	4.9	2.2	1.3
Multivitamins +/- minerals	2.5	3.2	5.6	-2.4	-0.9
Number of incorrect matches in round	2.5	4.2	4.2	-2.1	-2.0
Neuroticism score	2.5	5.2	10.2	-0.3	3.2
Smoking status: Previous	2.5	3.8	7.5	-2.7	-0.2
Ever had hysterectomy (womb removed)	2.4	2.7	4.8	-0.7	2.2
Heart attack	2.4	3.1	5.7	0.7	2.4
Commuting to job workplace: Car/motor vehicle	2.4	2.8	3.7	-1.4	1.9
Medication: Gliclazide	2.4	2.7	3.1	1.5	1.8
Fractured/broken bones in last 5 years	2.4	3.1	3.6	-1.9	-1.6
Qualifications: O levels/GCSEs or equivalent	2.3	3.6	6.8	0.6	-2.6
Alcohol drinker status: Never	2.3	2.7	5.0	2.2	0.7
Fasting Glucose	2.2	2.6	3.5	1.3	1.9
Medication: Lansoprazole	2.2	2.5	4.4	0.7	2.1
Illnesses of mother	2.2	2.7	3.1	-1.5	-1.8
Breastfed as a baby	2.2	2.7	3.8	-1.3	-2.0
Shortness of breath walking on level ground	2.2	2.7	5.3	0.3	2.3
Commuting to job workplace: Walk	2.2	2.3	4.5	0.4	-2.1
Noisy workplace	2.1	2.6	4.9	-0.5	2.2
Mouth/teeth dental problems: Loose teeth	2.1	2.5	3.1	1.4	1.8
Neck or shoulder pain in last month	2.1	3.0	4.2	-1.3	2.1
Number of self-reported non-cancer illnesses	2.1	3.6	7.1	-0.1	2.7
Ever taken oral contraceptive pill	2.1	2.3	4.5	-2.1	-0.3
Irritability	2.1	3.6	6.8	-2.6	-0.7
Triglycerides	2.0	3.3	4.8	2.2	1.4
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.3	1.8	1.1
Neuroticism	2.0	4.9	9.3	-0.6	3.1
Chronic bronchitis/emphysema (father)	2.0	2.4	4.1	-2.0	0.8
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.2	4.7	-1.3	2.2
Trunk fat-free mass	2.0	11.5	23.1	-0.0	4.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	5.7	-2.4	0.6
Medication: Allopurinol	2.0	2.7	3.4	1.8	1.4
Trunk predicted mass	1.9	11.0	22.1	-0.0	4.7
Tinnitus: Yes, now most or all of the time	1.9	2.2	3.4	1.8	1.0
Heart attack/myocardial infarction (self-reported)	1.9	2.4	4.5	0.6	2.1
Alzheimer’s Disease (including proxy)	1.8	2.7	2.8	1.6	1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	3.5	0.8	-1.9
Number of full sisters	1.8	2.2	3.4	-1.0	1.8
Schizophrenia (2018)	1.7	3.6	4.1	-1.8	-2.0
Impedance of leg (left)	1.7	8.3	8.6	2.9	-2.8
Had menopause	1.7	2.1	3.2	-1.0	-1.8
Glaucoma (self-reported)	1.7	2.0	4.0	0.2	-2.0
Asthma (self-reported)	1.7	3.4	6.7	0.1	2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	5.9	1.1	-2.4
Commuting to job workplace: Cycle	1.7	2.1	2.4	1.5	-1.4
Major Depression (MDD)	1.6	1.9	2.2	-1.5	1.2
Body Mass Index (BMI) (2010)	1.6	2.2	4.4	0.1	2.1
Cardiovascular Disease	1.6	5.2	7.2	1.8	2.7
Diabetes (father)	1.6	2.0	2.9	1.1	1.7
Current tobacco smoking	1.6	2.6	3.1	-1.5	1.8
Medication: Atenolol	1.6	2.0	3.9	0.4	2.0
Had other major operations	1.6	1.9	3.8	-2.0	0.2
Happiness	1.6	2.0	2.1	-1.4	-1.5
Asthma	1.6	3.1	6.2	0.2	2.5
Gout (self-reported)	1.6	2.2	2.4	1.4	1.5
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.0	0.1	2.0
Bipolar Disorder or Schizophrenia	1.5	3.7	6.3	-2.5	-1.0
Neuroticism (Nagel 2018)	1.5	3.5	6.4	-0.8	2.5
Schizophrenia (2014)	1.5	3.4	3.6	-1.9	-1.8
Respiratory disease	1.5	3.3	6.6	-0.2	2.6
Lung FVC	1.5	7.5	14.9	0.2	-3.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.6	6.1	1.8	-2.5
Heart disease (mother)	1.5	1.9	2.0	-1.3	-1.4
Medication for cholesterol	1.5	2.2	2.3	-1.5	-1.5
Severe depression (siblings)	1.4	1.6	2.3	-1.5	-0.9
Impedance of leg (right)	1.4	6.6	6.9	2.6	-2.5
Worrier / anxious feelings	1.4	2.6	3.6	1.3	1.9
Illnesses of siblings: Diabetes	1.4	1.7	3.2	-0.3	1.8
Average weekly red wine intake	1.4	2.1	3.3	0.9	-1.8
Smoking status: Current	1.4	2.2	3.8	-0.8	1.9
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.2	-0.5	1.8
Bipolar Disorder (2018)	1.3	2.1	3.3	-1.8	0.9
Neuroticism (2016)	1.3	1.8	3.0	-0.8	1.7
Systolic blood pressure, automated reading	1.3	3.9	6.8	1.0	2.6
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	1.8	-1.2	-1.3
Forced vital capacity (FVC), Best measure	1.3	4.7	7.5	1.4	-2.7
Illnesses of father: High blood pressure	1.3	1.6	3.1	1.8	0.4
Frequency of depressed mood in last 2 weeks	1.2	1.7	1.8	-1.2	1.3
Alcohol usually taken with meals	1.2	1.9	3.7	0.2	-1.9
Comparative body size at age 10	1.2	3.2	5.8	-2.4	0.8
Medication for pain relief, constipation, heartburn	1.2	2.0	2.6	1.6	-1.2
Back pain experienced in last month	1.2	1.7	3.4	-0.0	1.9
Commuting to job workplace: Public transport	1.2	1.4	2.7	0.3	-1.7
Depression (Nagel 2018)	1.1	1.6	2.9	-0.6	1.7
Worry (Nagel 2018)	1.1	2.2	3.3	1.1	1.8
Stomach or abdominal pain in last month	1.1	1.4	1.5	-1.2	1.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.4	2.1	-1.4	-0.8
Nervous feelings	1.1	2.1	2.2	1.4	1.5
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	4.3	1.8	-2.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.5	-0.6	1.6
Peak expiratory flow (PEF)	1.1	2.5	5.0	0.3	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.8	-1.7	-0.0
Medication: Ibuprofen	1.1	1.4	1.5	-1.2	1.1
Long-standing illness, disability or infirmity	1.1	1.7	3.1	0.6	1.8
Mineral and other dietary supplements	1.1	1.5	1.9	1.4	1.0
Hand grip strength (left)	1.0	2.7	3.9	1.2	2.0
Forced vital capacity (FVC)	1.0	3.7	5.8	1.3	-2.4
Financial difficulties in last 2 years	1.0	1.3	2.6	0.2	1.6
High blood pressure (siblings)	1.0	1.5	2.7	-0.5	1.6
Primary Biliary Cirrhosis	0.9	1.2	1.5	-1.0	-1.2
Supplements: Zinc	0.9	1.0	1.0	-1.0	-1.0
Hair/balding pattern: Pattern 2	0.9	1.2	2.4	0.2	1.5
Worry too long after embarrassment	0.9	1.5	3.1	-0.1	-1.8
High cholesterol (Self-reported)	0.9	1.5	2.8	1.7	0.4
Pack years of smoking	0.9	1.3	2.7	-1.6	0.1
Alzheimer’s Disease (in father)	0.8	0.9	1.1	0.8	1.1
Pack years adult smoking proportion	0.8	1.3	2.4	-1.5	0.5
Sitting height	0.8	5.5	10.1	3.2	0.9
Mouth/teeth dental problems	0.8	1.2	1.6	0.9	-1.3
Medication: Simvastatin	0.8	1.1	1.7	1.3	0.8
Time employed in main current job	0.8	0.9	1.8	-0.2	-1.3
Birth weight of first child	0.8	1.5	2.7	-0.5	-1.6
Mother’s age at death	0.8	1.0	1.4	0.8	-1.2
Medication: Lisinopril	0.8	1.0	1.3	1.1	0.9
Ever used hormone-replacement therapy (HRT)	0.7	1.0	1.9	-1.4	0.2
Serious illness, injury or assault to yourself	0.7	0.9	1.0	-0.9	-1.0
Length of working week for main job	0.7	0.7	0.8	0.8	0.9
Emphysema/chronic bronchitis	0.7	0.8	1.6	-1.3	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.2	-0.6	1.1
Rheumatoid Arthritis	0.6	0.9	1.4	-1.2	-0.6
Medication for hormone replacement therapy	0.6	0.6	1.1	-0.3	1.1
Medication: Ramipril	0.6	0.8	1.5	-0.0	1.2
Illnesses of siblings	0.6	0.9	1.3	0.7	-1.1
Comparative height size at age 10	0.6	3.4	5.6	2.4	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.0	1.0	0.5
Hearing aid user	0.6	0.6	0.7	0.7	0.8
Alcohol drinker status: Previous	0.6	0.7	0.7	-0.9	0.8
Ovarian Cancer	0.5	0.7	0.7	-0.9	-0.8
Lupus	0.5	0.8	1.6	-1.2	0.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.0	0.4	1.0
Medication: Aspirin	0.5	0.7	1.4	1.2	0.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.9	0.6	-1.0
Wears glasses or contact lenses	0.5	0.6	1.2	0.0	1.1
Eye problems/disorders: Glaucoma	0.5	0.6	0.6	0.7	-0.8
Unable to work because of sickness or disability	0.5	0.6	1.3	-1.1	0.1
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.5	-0.6	-1.6
Height	0.4	6.8	13.5	3.7	-0.2
Allergy or Eczema	0.4	1.0	1.3	-0.8	-1.1
Hearing difficulty/problems: Yes	0.4	0.6	0.9	-0.5	-0.9
Supplements: Glucosamine	0.4	0.5	0.7	-0.5	-0.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	-0.3	-1.0
Standing height	0.4	4.4	8.8	3.0	0.0
Tense / ‘highly strung’	0.4	0.7	1.4	-0.3	1.2
Hair/balding pattern: Pattern 4	0.4	0.9	1.0	0.9	1.0
Blood clot in the leg (DVT)	0.4	0.5	0.8	0.4	0.9
Birth weight	0.4	0.9	1.1	-1.1	-0.9
Pulse wave peak to peak time	0.4	0.5	1.0	-0.1	-1.0
Heart disease (siblings)	0.4	0.5	0.9	-0.9	-0.3
Mean Putamen Volume	0.3	0.4	0.6	-0.8	-0.4
Hypothyroidism (self reported)	0.3	0.6	1.1	-1.1	0.3
Average weekly fortified wine intake	0.3	0.4	0.7	-0.8	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.0	-0.5	-1.0
Medication: Levothyroxine sodium	0.3	0.5	0.6	-0.6	0.7
Allergy	0.3	0.6	1.2	0.1	-1.1
Falls in the last year	0.3	0.4	0.6	-0.7	0.4
Headache pain in last month	0.3	0.6	0.7	-0.7	0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.0	-1.0	0.1
Eye problems/disorders: None of the above	0.3	0.4	0.7	-0.8	-0.2
Family relationship satisfaction	0.3	0.4	0.8	-0.9	0.0
Illnesses of father: Heart disease	0.3	0.4	0.7	-0.8	-0.4
Medication: Aspirin	0.3	0.4	0.7	0.8	0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	0.5	0.7	0.5
Medication: Blood pressure	0.3	0.5	0.9	0.9	0.3
Medication: Bendroflumethiazide	0.3	0.4	0.4	0.7	0.7
Risk taking	0.3	0.5	0.9	0.3	1.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	0.3	0.8
Lung FEV1/FVC ratio	0.2	1.2	2.3	1.5	0.3
Tanning	0.2	2.8	5.1	0.7	2.3
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.8	0.3
Loud music exposure frequency	0.2	0.2	0.2	-0.5	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.2	0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	0.6	-0.4
Supplements: Vitamin C	0.2	0.3	0.3	-0.5	-0.5
Breast cancer (self-reported)	0.2	0.3	0.4	-0.6	0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	-0.1	-0.7
Cholesterol lowering medication	0.2	0.3	0.5	0.7	0.3
LDL Cholesterol	0.1	0.1	0.2	0.5	0.1
Blood Platelet Count	0.1	1.6	1.9	-1.4	-1.1
Sensitivity / hurt feelings	0.1	0.2	0.2	-0.4	0.4
High blood pressure	0.1	0.2	0.4	0.2	0.7
High blood pressure (mother)	0.1	0.1	0.1	0.3	-0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.5	0.3
Medication: Amlodipine	0.1	0.1	0.1	0.4	0.0
Angina (self-reported)	0.1	0.1	0.2	-0.5	-0.3
Migraine (self-reported)	0.1	0.1	0.2	-0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	0.6	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	-0.5	0.2
Medication: Atorvastatin	0.1	0.2	0.3	0.2	0.6
Hair Pigment	0.0	0.8	1.6	-1.3	0.3
Angina	0.0	0.0	0.1	-0.3	0.0
Suffer from ‘nerves’	0.0	0.0	0.1	-0.3	0.0
Hypertension (Self-reported)	0.0	0.1	0.2	0.2	0.5
Eye problems/disorders: Cataract	0.0	0.0	0.1	-0.2	-0.0
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	0.1	0.1

Hub : Genes

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Trait associations