Best TWAS P=7.33e-14 · Best GWAS P=9.65e-12 conditioned to 0.052
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CYP2R1 | 0.06 | 0.05 | lasso | 5 | 0.04 | 9.3e-06 | 5.2 | -5.2 | 2.0e-07 | 0.22 | 0.33 | 0.66 | FALSE |
| 2 | GTEx | Artery Tibial | RRAS2 | 0.08 | 0.06 | lasso | 5 | 0.07 | 5.7e-06 | 5.5 | -5.5 | 5.1e-08 | 0.30 | 0.84 | 0.12 | FALSE |
| 3 | GTEx | Lung | RRAS2 | 0.05 | 0.03 | lasso | 1 | 0.05 | 2.2e-04 | 5.2 | -5.2 | 2.0e-07 | 0.43 | 0.40 | 0.06 | FALSE |
| 4 | GTEx | Testis | RRAS2 | 0.18 | 0.13 | enet | 19 | 0.15 | 2.7e-07 | 5.2 | -5.4 | 8.4e-08 | 0.25 | 0.77 | 0.21 | FALSE |
| 5 | YFS | Blood | PSMA1 | 0.01 | 0.00 | bslmm | 380 | 0.00 | 2.1e-01 | -1.9 | 5.2 | 1.7e-07 | -0.55 | 0.05 | 0.07 | FALSE |
| 6 | YFS | Blood | RRAS2 | 0.16 | 0.14 | enet | 53 | 0.19 | 8.5e-59 | -6.8 | 6.8 | 7.2e-12 | -0.86 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RRAS2 | 0.13 | 0.01 | blup | 11 | 0.05 | 4.0e-03 | -5.6 | -7.5 | 7.3e-14 | 0.73 | 0.01 | 0.57 | TRUE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RRAS2 | 0.08 | 0.03 | blup | 11 | 0.05 | 9.9e-03 | -6.8 | -7.1 | 1.6e-12 | 0.88 | 0.00 | 0.79 | FALSE |