Best TWAS P=6.91e-19 · Best GWAS P=1.08e-18 conditioned to 0.398
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | AMPD3 | 0.14 | 0.11 | lasso | 3 | 0.09 | 1.7e-07 | 5.1 | -5.3 | 1.4e-07 | -0.14 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Cerebellum | AKIP1 | 0.15 | 0.03 | lasso | 7 | 0.03 | 5.9e-02 | 4.6 | 5.5 | 2.9e-08 | 0.07 | 0.04 | 0.70 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | AMPD3 | 0.20 | 0.02 | lasso | 8 | 0.01 | 5.5e-02 | 6.9 | -6.8 | 8.3e-12 | -0.22 | 0.30 | 0.05 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | SBF2 | 0.16 | 0.14 | lasso | 4 | 0.14 | 6.8e-11 | -4.8 | 5.6 | 1.9e-08 | 0.39 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | AKIP1 | 0.12 | 0.09 | enet | 18 | 0.10 | 4.4e-08 | 4.4 | 5.2 | 2.3e-07 | 0.05 | 0.23 | 0.77 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | ZBED5-AS1 | 0.22 | 0.08 | lasso | 6 | 0.08 | 1.3e-06 | 5.0 | 5.8 | 7.1e-09 | 0.03 | 0.70 | 0.30 | TRUE |
| 7 | GTEx | Esophagus Gastroesophageal Junction | AMPD3 | 0.22 | 0.17 | lasso | 4 | 0.12 | 4.1e-05 | 6.4 | -5.8 | 8.2e-09 | -0.16 | 0.44 | 0.04 | FALSE |
| 8 | GTEx | Esophagus Muscularis | TMEM9B | 0.12 | 0.06 | lasso | 7 | 0.10 | 9.5e-07 | -4.3 | -5.3 | 1.0e-07 | -0.09 | 0.12 | 0.84 | FALSE |
| 9 | GTEx | Heart Left Ventricle | AMPD3 | 0.14 | 0.07 | lasso | 4 | 0.07 | 1.5e-04 | 5.2 | -5.8 | 6.0e-09 | -0.17 | 0.66 | 0.02 | FALSE |
| 10 | GTEx | Muscle Skeletal | AMPD3 | 0.12 | 0.03 | lasso | 4 | 0.03 | 6.7e-04 | 5.0 | -5.3 | 1.1e-07 | -0.15 | 0.69 | 0.01 | FALSE |
| 11 | GTEx | Pancreas | AMPD3 | 0.19 | 0.12 | lasso | 5 | 0.13 | 5.1e-06 | 5.1 | -5.7 | 1.4e-08 | -0.14 | 0.70 | 0.02 | FALSE |
| 12 | GTEx | Prostate | SBF2 | 0.21 | 0.05 | lasso | 7 | 0.03 | 6.7e-02 | -7.5 | -8.3 | 8.0e-17 | -0.86 | 0.04 | 0.76 | FALSE |
| 13 | GTEx | Small Intestine Terminal Ileum | AKIP1 | 0.23 | 0.20 | enet | 11 | 0.12 | 1.4e-03 | 5.2 | 5.2 | 1.7e-07 | 0.05 | 0.08 | 0.82 | FALSE |
| 14 | GTEx | Testis | SBF2 | 0.10 | 0.01 | lasso | 5 | 0.02 | 5.0e-02 | -7.2 | 7.6 | 2.3e-14 | 0.82 | 0.07 | 0.82 | FALSE |
| 15 | METSIM | Adipose | ADM | 0.05 | 0.03 | blup | 481 | 0.03 | 6.5e-05 | 7.1 | 7.7 | 1.5e-14 | 0.50 | 0.81 | 0.02 | FALSE |
| 16 | METSIM | Adipose | AMPD3 | 0.06 | 0.03 | enet | 14 | 0.05 | 7.8e-08 | -6.1 | -6.8 | 1.0e-11 | -0.08 | 0.96 | 0.00 | TRUE |
| 17 | NTR | Blood | ADM | 0.04 | 0.04 | enet | 13 | 0.04 | 1.6e-13 | -7.5 | 8.9 | 6.9e-19 | 0.88 | 0.17 | 0.83 | TRUE |
| 18 | ROSMAP | Brain Pre-frontal Cortex | SBF2-AS1 | 0.03 | 0.00 | bslmm | 362 | 0.01 | 4.4e-03 | 3.1 | -7.0 | 2.6e-12 | -0.59 | 0.06 | 0.48 | FALSE |
| 19 | YFS | Blood | ADM | 0.08 | 0.11 | enet | 25 | 0.12 | 9.4e-36 | -7.5 | 6.8 | 8.0e-12 | 0.85 | 0.98 | 0.02 | FALSE |
| 20 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ADM | 0.08 | 0.02 | blup | 36 | 0.03 | 1.8e-02 | 5.4 | -6.5 | 7.1e-11 | -0.61 | 0.03 | 0.27 | FALSE |
| 21 | The Cancer Genome Atlas | Rectum Adenocarcinoma | SCUBE2 | 0.16 | 0.05 | blup | 78 | 0.06 | 1.3e-02 | 5.7 | -5.4 | 6.4e-08 | -0.07 | 0.02 | 0.70 | FALSE |
| 22 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ZNF143 | 0.19 | 0.04 | enet | 12 | 0.08 | 6.9e-04 | 3.0 | 5.3 | 1.1e-07 | 0.10 | 0.01 | 0.21 | TRUE |